LOCUS       gnlProkkaCPMAHIBI_27   14636 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CPMAHIBI_27.
ACCESSION   gnlProkkaCPMAHIBI_27
VERSION     gnlProkkaCPMAHIBI_27
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 00:56:08
            Original ID  :: gnl|Prokka|CPMAHIBI_27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14636
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14636
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3193:4636]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3194..4636
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..14636
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14636
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             162..398
                     /locus_tag="ctg27_1"
                     /transl_table=11
                     /translation="MKEKCSLDKLPLGVTGIVYRVNCNENIKNRIFDFGIMENSPVIPL
                     FTSPFGDPSAYLVKNAVVALRNNDCKDIIVTPE"
     CDS             414..2327
                     /locus_tag="ctg27_2"
                     /transl_table=11
                     /translation="MFSTDKSSFNKKDVSDWDYKISLAGNPNVGKSTIFNELTGLRQHT
                     GNWTGKTVEFARGCCKIKDARFCITDLPGCYSLLSFSGEEAVTRECLIQNQNDCVVIVV
                     DCGVIERNLSFALQVLSVTKNAVLCLNLCDEAEKNGIKIDCDELSLNLGIPVVKTCATD
                     KKGLDELKKAIYNVCSGKIKCFRVERNFEGVDILSEKNYKQNIEKLSQIGNKISSDCVK
                     YEKSELNACTRKLDKILTSKTTGIPIMLAMLGILFWITVVGANYPSEWLSNLFGFIKEK
                     LYILFDFLHAPDVVTGLLIDGVYTTLSWVVSVMLPPMAIFFPLFSLVEDSGYLPRIAFN
                     LDRYFSKCGAHGKQSLAMAMGLGCNACGVTGCRIIESPKERLIAILTNNFMPCNGRFPT
                     IIALLLMFFAGTAFTLSSSLEVAALLIGIIVFCVFITLVISKVLSVTILKGEQSGFVLE
                     LPPYRKPQILKTIVRSLLDRTLFVLGRAVAVAAPAGAIIWILANVHISDVSLLKYCTDF
                     LDPFGRFIGVDGVIIMAFILGFPANETVIPIIIMSYMASGTLVDYSSYDQLFQLLSMNG
                     WTITTAVCTIILCILHYPCSTTCLTIKKETGSLKWTLVSMALPTAMGIVLCMITAGVMR
                     LF"
     CDS             complement(2319..3128)
                     /locus_tag="ctg27_3"
                     /transl_table=11
                     /translation="MNEKIIMLGTGSAMVTDCYNTCFLLKSENDCLLVDAGGGNGILSA
                     IKKSGVAWNSIKTMFITHSHTDHILGAVWVIRQISALMNSGKYDGNFNIYCHDECVDSI
                     TAICNHTLAPKFLKNINTKIFINEVKDGEMQNAGSIRLTFFDIFSDKTKQFGFKAVFPS
                     GKVLACLGDEPFNEKCRNFVQNCDYLMCEAFCLYSQKDIFKPYEKFHSTALDAGKLAES
                     LFAKNLILYHTEDETLQTRKKTYTSEARTVFNGNIFVPDDFEVIDLK"
     CDS             complement(3194..4636)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_4"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 2.9e-31,
                     bitscore: 98.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.4e-15, bitscore: 46.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.3e-15, bitscore: 48.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2e-20, bitscore: 63.7,
                     seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIKDYRRFPKGLTAFLLSNGDIMIHQYKLNGYNIVLDVYSGSVH
                     AVDDLAYDVIAMYKNATKEQIIDEMLSKYADNPEITKEEISDCIDDVKELEKQGKLFTD
                     DKYENLAFDFKKRNTVIKALCLHIAHTCNLNCEYCFASQGKYHGERALMSFEVGKRAID
                     FLIENSGSRVILEVDFFGGEPLMNFDVVKQIVAYARSIEKEHNKNFRFTLTTNGMLVDD
                     DVIEFANKECHNVVLSLDGRKEVHDHLRKTVNGKGSYDIIVPKFQEFVKKRGNKGYYVR
                     GTYTHNNTDFTNDIFHMADLGFTELSMEPVVCAPDDPYALTYDDLPILFEQYEILAKEM
                     LKREKEGRPLTFYHYMIDLTGGPCIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDEKY
                     KLGDIFNGVSNTKIQDEFKLCNAYARPDCKDCWARLYCSGGCAANAYHATGSITGIYEY
                     GCELFRKRMECAIMMKVAEAEG"
     CDS             complement(4863..6266)
                     /NRPS_PKS="Domain: Aminotran_5 (54-217). E-value: 1.6e-12.
                     Score: 38.9. Matches aSDomain:
                     nrpspksdomains_ctg27_5_Aminotran_5.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_5"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.2e-11, bitscore:
                     34.0, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1e-08, bitscore:
                     25.3, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.1e-12, bitscore:
                     38.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYDKLKNYSKSGIYPFHMPGHKRTDITEEGIIPYNIDITEIHDF
                     DNLHSPNGVIDEIQKKAAKLYNAKNAFILINGSTGGILSAIRSMTNQGNKILMARNCHK
                     SVYNSAELFNLNVDYIFPDTDSRYNILTSVSPCDIEDKLTKHNDEIRLVIITSPTYEGV
                     VSDIKSISEICHKHGAKLLVDEAHGAHFPFSDSFPDEALNCGADAAVLSLHKTLPSLTQ
                     TALLITNDSELSEILAENLAVFETSSPSYILMSSIEKCLDLCENSKDKFNEYCCNLKTV
                     REKLKNLKYLKIYDKSDTDFDYDIGKIVISTANANISGTKLAEILRNNYQIETEMAYSD
                     YVIAMTSVCDTEKAFDMLSDALISIDSELSKGADTERVPLKNLYTGKNFNACELYKFNK
                     ETIPFQNSEFRTSAEYIWAYPPGIPLIVPGEIISKELINYIEYLSACKVEIMSTKGGMT
                     DNISVVKKD"
     aSDomain        complement(5616..6104)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg27_5_Aminotran_5.1"
                     /evalue="1.60E-12"
                     /label="ctg27_5_Aminotran_5.1"
                     /locus_tag="ctg27_5"
                     /protein_end="217"
                     /protein_start="54"
                     /score="38.9"
                     /tool="antismash"
                     /translation="IDEIQKKAAKLYNAKNAFILINGSTGGILSAIRSMTNQGNKILMA
                     RNCHKSVYNSAELFNLNVDYIFPDTDSRYNILTSVSPCDIEDKLTKHNDEIRLVIITSP
                     TYEGVVSDIKSISEICHKHGAKLLVDEAHGAHFPFSDSFPDEALNCGADAAVLSLHKTL
                     "
     CDS             complement(6290..7783)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 87.9; E-value:
                     1.1e-26)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_6"
                     /transl_table=11
                     /translation="MLYGGAINLAGSVKGKRTAKHAVSDWMEIEKQRGISVTSSVLQFK
                     YNGYCINILDTPGHEDFSEDTYRTLMAADSAVMVIDGSKGVEKQTIKLFKVCVMRNIPI
                     ITFINKMDRDAKNSFDLLEDIENVLGIHTYPVNWPIGSGKEFKGVYDRNSKKILAFTAN
                     NGQKEVEKKELTLDDPALEDTIGYYHKQDLFDEIELLDGAGDEFDLEAVRNGQLTPVFF
                     GSALTNFGVEPFLEQFLQLTTPPLPRETVDEKVEPMSDFFSAFVFKIQANMNKAHRDRV
                     AFMRICSGKFEKNMEVFHVQGNKKMRLSQPQQIMAQEREIVDEAYAGDIIGVFDPGIFS
                     IGDTICSPGHKVQFRGIPTFAPEHFALVRQKDTMKRKQFIKGTSQIAQEGAIQIFQELD
                     AGMEEVIVGVVGVLQFDVLKYRLQNEYNCDIIMETLPYEFIRWIVNDDIDPKTLDLASD
                     TKKIQDLKGNHLLLFTSYWSINWALEHNKGLELAEFGTN"
     CDS             8042..9226
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_7"
                     /sec_met_domain="PF04055 (E-value: 8.5e-21, bitscore: 65.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFPIFSYTFQIEAETCVSASKSFMRFFMSNSIGLYIHIPFCKHK
                     CPYCDFFSGNADENAFDNYVIELKDKIKYWSEKAKRDVATVYFGGGTPSVLGADRLCDI
                     LDFIKFNFNIQNNAEITVEVNPDSAKTIDFKKMYACGFNRISMGMQTAVEDELRLLGRI
                     HSIDDAKTSVERAKSAGFNNISLDLMMGIPNQTIESLEKSISFCADCKVTHISSYILKI
                     EENTPFYKVQNKLKLADDDMQAEMYLRAVEKLDSLGYKQYEISNFAKQGYESRHNTNYW
                     RCGEYIGIGPSAHSFFEGKRFFYSRSMDDFNNNKLSFEGTGGDEEEFIMLSLRLKSGLN
                     YSEFEKKFGYTLPSYIIKKAKEYEKYGYTNVTDKSISFTPKGFLVSNSIISELI"
     CDS             complement(9286..10185)
                     /locus_tag="ctg27_8"
                     /transl_table=11
                     /translation="MKFCKYCGAQLEDNAVCNCEKSRAAQAQAQQANAQAQSQYQQPVH
                     PQQPQYQNPVQQQYTQPQNPQTQQSPYAVNNTAPIGENAFVKALKNIPVVFTSFFKDSK
                     TVIKTAKAEKDIILGALFSAIFFIALILGNMFLMLSMSALDFPKTLLVSLVTAVLIGGF
                     YSVILFAYVKKYKTEENTAKAFIDSFITFSIESIPASIGWILAGLSALISVYMFLFFFV
                     IVMLYLVISLVNQVKANVPEAKNSALFTLILTLIVAVAFMIIFFIGAKLTMWSFNTGTF
                     TTSVLTSLIGGGSYPSWY"
     CDS             complement(10437..11144)
                     /locus_tag="ctg27_9"
                     /transl_table=11
                     /translation="MDNSSNMAVNTTPTANQINPEHHYGLDKNKACLNNSCPSNTADSG
                     CYIPAIDEIMRHNQGAPSVAHPNMTEKVQKSNDNPSLEQAEIAYEEGGSTSEEQPENIN
                     KYSGSLQNIPFIKDLKKIDTFIPVLPATPATTASSGATVATPIRQNIGMSMSDYQYPFP
                     VTAESLRYHNGFMRTQIGRRITVDFLMGANTIVQKTGYLLGVAQDYILINEIDTNDITT
                     CDYYNIKFIRYYY"
     CDS             complement(11159..11596)
                     /locus_tag="ctg27_10"
                     /transl_table=11
                     /translation="MSTRELLARLLKCEAGGEGENGMRAVASVIVNRTRVPNGEFARVS
                     KGGDFRAIMEQPNQFTCLKTTVGGQYNPQNVYNIRPDEIHYNIADWALAGNTDSSVGNS
                     IFYFNPFSDTCPTFFPSNNGVIYNRVGDHCFYSPTEAYSKT"
     CDS             complement(11796..12113)
                     /locus_tag="ctg27_11"
                     /transl_table=11
                     /translation="MDEEYDDWLVNDDGKNNINDLIKETVALETTGKTGFFYLDKKRTQ
                     NIFKKSGYQLPSQLKNSGSNIIIRTIDDSVNKKSIILLKANNLSDGSVIGKIALQKQVK
                     R"
     CDS             complement(12324..12704)
                     /locus_tag="ctg27_12"
                     /transl_table=11
                     /translation="MVILGFEINPKHGGKFSEVLTAEEWRKFTHAMSTGLDSGLRINDN
                     SILVECEVDSKYQYKLVIYDNTFDDNPLEKVYAIRNIDYNITDGNKIANFIIKLEENNY
                     DSKKVFRQLLRDYTKQFELILG"
ORIGIN
        1 aattataaca cctgtttata gtcgtgtcaa ttccttaaaa tttttctgat atcagagttt
       61 attcgggtac gatataagtt tagtttatgg ccggcttttt gtgtaactca gttgtatgaa
      121 ttgaatatgc tgttaataaa aagttgaaat cggtgaatca gatgaaagaa aaatgttcgc
      181 ttgacaagtt accgcttgga gttacgggga ttgtctatcg tgtgaactgt aatgaaaata
      241 tcaaaaacag aatatttgat tttggtatta tggagaacag tcctgttatc cccttgttta
      301 caagtccgtt cggtgatccg tctgcgtatc ttgttaaaaa tgccgttgtg gcactgagaa
      361 ataacgattg caaagatatc attgttactc ctgaataaaa ggaggctttt ttattgtttt
      421 ctacggataa atcatctttt aataaaaagg atgtatcgga ttgggattac aaaatttcac
      481 ttgccggtaa tcctaatgta ggcaagagta caatttttaa cgaactgacg ggattaagac
      541 agcacacggg aaactggacg ggtaaaacag ttgagtttgc cagaggttgt tgcaaaatca
      601 aagacgcaag attttgtatt acggacttac cgggatgcta ttccctgctt tcattttcgg
      661 gcgaagaggc ggtaacaagg gagtgtctta tacaaaatca aaatgactgc gttgtaatag
      721 ttgttgactg cggagttatt gaaagaaatc tttcatttgc attgcaggtg ttatctgtca
      781 caaagaatgc tgttctttgt cttaatcttt gtgatgaggc tgaaaaaaac ggtataaaaa
      841 tcgactgcga cgagttatcg ctaaatcttg gaatacctgt tgtgaaaacc tgtgcaacag
      901 acaaaaaagg tttggatgaa ttaaaaaaag cgatctataa tgtatgcagc ggaaagataa
      961 aatgttttag ggtagaaaga aattttgaag gcgttgatat actatccgaa aaaaactaca
     1021 aacagaatat tgaaaagctt tcgcaaattg gcaacaaaat ttcaagtgac tgcgtaaaat
     1081 atgaaaaatc agagttaaat gcttgtacaa gaaagcttga taaaatactt acaagcaaaa
     1141 ccacgggaat accgattatg ctggcaatgc ttggcatatt gttctggata acggttgtcg
     1201 gtgcaaatta tccgagcgaa tggttaagca atttgtttgg ctttataaaa gagaaactgt
     1261 atattctttt tgatttttta cacgctcccg atgttgtaac gggacttttg attgacggag
     1321 tttatacaac tctgtcatgg gtggtatctg taatgctgcc gcctatggct atattctttc
     1381 cgctattttc acttgttgag gattcgggat atctgccgag aattgcattt aatcttgata
     1441 ggtatttttc aaagtgcggt gcacacggaa agcaaagtct tgctatggca atggggcttg
     1501 gctgtaatgc ctgcggagtt acgggttgca gaatcatcga gtcaccaaag gaacggctga
     1561 ttgcaattct tacaaataat tttatgccgt gtaacggacg gtttcccaca atcattgcat
     1621 tactgctcat gttctttgca ggtacggcat ttacgctgag cagttcgctt gaggtagcgg
     1681 cattgttgat tggaataata gttttctgtg tttttataac acttgttata tctaaggtac
     1741 tttcagtcac aatattgaaa ggcgaacagt ccggatttgt gcttgagctt ccgccgtaca
     1801 gaaagccgca gattttaaaa actattgtcc gttcgctgtt ggacagaaca ttatttgttt
     1861 taggaagggc tgttgcggtt gccgctccgg caggtgcgat aatctggatt cttgcaaatg
     1921 tgcatataag cgatgtttca cttttaaaat actgtactga ttttttagat ccgttcggca
     1981 gatttatcgg ggttgacggc gttataataa tggcatttat acttggattt cctgcgaatg
     2041 aaaccgttat tccgattata attatgtcat atatggcaag cggtactctt gttgattatt
     2101 caagctacga tcagctgttt caacttctca gtatgaacgg ctggacgatt acaacggctg
     2161 tatgcacgat tattctttgt attcttcatt atccgtgttc aacaacctgt ctgacaataa
     2221 aaaaagaaac aggcagcctt aaatggacgc ttgtttctat ggctttgcct actgcaatgg
     2281 gaattgtgct ttgtatgatt acagcaggtg ttatgagatt attttaagtc aataacttca
     2341 aaatcatcgg gaacaaatat atttccgtta aaaactgttc tcgcctctga agtatatgtt
     2401 tttttgcgtg tttgaagtgt ttcgtcctcg gtgtgataca ggataagatt ttttgcaaaa
     2461 agactctctg caagttttcc tgcatcaagc gctgtgctgt ggaatttttc gtagggctta
     2521 aaaatatctt tttgactgta aagacaaaaa gcttcacaca taagataatc gcagttttga
     2581 acaaaatttc tgcatttttc attgaacggt tcatcaccga gacaggcgag aacttttcct
     2641 gacggaaaaa cagccttgaa tccgaattgc tttgttttgt ctgaaaatat atcaaagaaa
     2701 gtgagtcgga tactgccggc attttgcatt tcaccgtctt ttacttcatt gatgaaaatt
     2761 tttgtattga tatttttgag aaatttcggt gcaagtgtgt ggttgcaaat tgccgtgatt
     2821 gaatcaacac attcatcgtg gcagtaaata ttaaaattac cgtcatattt gcctgaattc
     2881 ataagagcgc ttatttgcct tattacccac acggcaccta atatatggtc ggtgtgagaa
     2941 tgagtaataa acattgtttt tatgctgttc caagctactc cggatttctt aattgcggat
     3001 aaaattccgt ttccgccgcc tgcgtcaaca agaagacagt cgttttcgga tttcagaaga
     3061 aaacaggtat tataacagtc ggtaaccatc gcacttcctg tgccgagcat aataattttt
     3121 tcgttcatac agcacctcga aaatacaggc agatacaaga aaaatgtatc tgcctgtaaa
     3181 ttttattgta attttatcct tctgcttctg caaccttcat cataatggca cattccattc
     3241 tttttctgaa aagctcacag ccgtattcgt aaatacctgt gattgagcct gttgcatgat
     3301 aagcgtttgc ggcacaaccg ccgctgcaat aaagtcttgc ccagcagtct ttgcagtcgg
     3361 gacgggcgta tgcgttacaa agcttaaatt cgtcctgaat tttcgtgttt gaaacaccgt
     3421 taaagatatc gccgagcttg tacttttcat cgcctacaaa ttgatgacag ggatagaggt
     3481 cgccccaagg tgttacagcc atatattctg tacccgaacc gcaacccgag attctcttat
     3541 aaatgcacgg accgcctgta aggtcaatca tataatgata gaaggtgagc ggtctgccct
     3601 ctttttcacg cttgagcatt tcctttgcaa gaatttcgta ctgttcaaaa aggataggca
     3661 aatcgtcata tgtaagtgca tatgggtcat cgggagcaca tacaaccggc tccattgaaa
     3721 gctctgtaaa tcccaaatcc gccatatgga aaatatcgtt tgtgaagtct gtgttattat
     3781 gtgtataagt gcctcttaca tagtaaccct tgttgcctct ttttttgaca aattcctgga
     3841 atttcggaac gataatgtca taactgccct tgccgtttac agttttgcga agatggtcat
     3901 gcacttcttt tctgccgtca aggctgagaa ctacattatg acattctttg tttgcaaatt
     3961 caattacatc gtcatcaaca agcataccgt ttgttgtaag tgtaaaacgg aagtttttgt
     4021 tgtgttcctt ttcaatgctt cttgcatagg caacaatctg ctttacaacg tcaaagttca
     4081 taagaggttc tccgccgaag aagtcaacct caagtattac tctgctgcct gaattttcaa
     4141 tgagaaagtc aattgctctc ttgcccactt caaagctcat cagcgctctc tcgccgtggt
     4201 atttgccctg acttgcaaag cagtattcgc agttaaggtt acaggtgtga gcaatgtgca
     4261 gacaaagtgc tttgattact gtgtttctct ttttaaagtc aaatgcaagg ttttcgtact
     4321 tgtcgtctgt aaagagcttt ccctgtttct caagctcttt tacatcatca atgcagtctg
     4381 agatttcttc ttttgtaatc tcaggattgt ctgcatattt tgaaagcatt tcgtcgatta
     4441 tctgttcttt tgttgcgttt ttgtacattg caataacatc ataagcaagg tcatcgactg
     4501 cgtgtacact gccgctgtaa acatcaagaa ctatgttgta tccgttaagt ttatactgat
     4561 gaatcataat atctccgtta gacaaaagga aagccgttaa ccctttggga aaacggcgat
     4621 aatccttaat aatcaaatta aaatagaatt atttctcgct catgcacttt tcacactgct
     4681 ggttagcaac gccgcaagat gtcttacacg ctgactgaca tgaagtctgg cactcgccgc
     4741 aaccgcctgt cttaacgctc ttcttgaggt cacgagtttc gatagtttta attctcttca
     4801 taataaatca aactccttgt tagattttgt tagtttaata ttatcacaca gccattgatt
     4861 tgtcaatctt ttttaactac gcttatgttg tccgtcatac cgccttttgt tgacataatc
     4921 tcaaccttgc aggctgaaag atattcaatg taatttataa gttccttgct tataatttca
     4981 ccgggtacga tgaggggaat tccgggtgga tatgcccaga tatactcggc agaagttctg
     5041 aattccgaat tttgaaacgg aatagtttct ttgttgaatt tgtacaactc gcaggcgttg
     5101 aaatttttgc ctgtgtagag attttttaac ggaacacgct cggtgtcggc tccttttgaa
     5161 agttcgctgt caattgaaat cagagcgtct gaaagcatat caaaagcttt ttcagtgtca
     5221 caaacagatg tcatggcaat tacatagtcc gaatatgcca tttcggtttc aatctgataa
     5281 ttatttcgca gtatttcggc aagctttgtt cccgaaatat ttgcgttcgc tgttgaaatt
     5341 acaattttgc cgatatcata atcaaaatca gtatcgcttt tatcataaat tttcagatat
     5401 tttagatttt taagtttttc tctgaccgtt ttaagattgc aacaatattc attgaattta
     5461 tctttgctgt tttcgcataa atcaagacat ttttcaattg aactcattaa aatatatgac
     5521 ggactgcttg tttcaaatac agctaaattt tcggcaagaa tttcagaaag ctcgctgtca
     5581 tttgttatga gcaatgcagt ttgagttaat gacggcaaag ttttgtgcag actcaatact
     5641 gcggcgtctg caccgcagtt aagtgcttca tcgggaaaac tgtccgaaaa cggaaaatgc
     5701 gctccgtgag cttcgtcaac aagtaatttt gctccgtgtt tgtgacagat ttcggagatt
     5761 gactttatat ccgaaacaac tccttcatat gtaggcgaag ttatgattac aagtctgatt
     5821 tcatcattgt gttttgtaag tttatcttct atatcgcaag gtgaaaccga tgtaagaata
     5881 ttgtatctgc tgtctgtatc gggaaaaatg taatcgacat tgagattaaa caattctgct
     5941 gaattatata cagatttgtg gcagttacga gccattaaga tcttgttgcc ttgatttgtc
     6001 attgagcgaa ttgctgaaag tattccgcct gttgaaccgt taatcagaat gaaagcattt
     6061 tttgcattgt aaagttttgc agcctttttc tgaatttcgt caataactcc atttggcgaa
     6121 tggagattgt caaaatcatg aatttcggtt atgtcgatat tatacggtat tataccctct
     6181 tctgtaatgt ccgttctttt gtgtccgggc atatgaaaag gatatatgcc gctttttgaa
     6241 taatttttaa gcttgtcgta cagcatatat cctccgatat tttaaatatt tagtttgtac
     6301 cgaactcagc gagttcaagt cccttgttgt gttcaagcgc ccagtttatg ctccagtagc
     6361 ttgtaaagag caaaagatga ttgcctttaa gatcctgaat tttcttagta tcggacgcaa
     6421 ggtcgagagt tttcggatca atgtcatcgt ttacaatcca acggataaat tcatatggga
     6481 gtgtttccat aatgatatca cagttgtact cgttttgaag tctgtattta agaacatcaa
     6541 actgaagtac gcctacaacg ccaacgataa cttcctccat acctgcgtca agctcctgga
     6601 aaatttgaat tgcaccttcc tgtgcaatct gacttgtacc cttgatgaac tgtttgcgct
     6661 tcattgtgtc tttctgacgg acaagtgcaa agtgttcggg agcaaatgta ggaattcccc
     6721 tgaactgtac cttgtgtccc ggtgaacaga ttgtgtcacc gattgagaaa atgcccggat
     6781 caaacacacc gatgatgtcg cccgcatatg cctcgtcaac aatttctctt tcctgagcca
     6841 taatctgttg tggctgtgaa agacgcattt ttttgttacc ctgaacatgg aacacttcca
     6901 tattcttttc aaacttgcca ctgcagatgc gcataaatgc aactctgtca cggtgagcct
     6961 tattcatatt tgcctgaatt ttgaaaacaa atgcagagaa aaagtctgac ataggctcaa
     7021 ccttttcatc aactgtttct cttggcagag gtggagttgt gagctgtaag aactgttcaa
     7081 ggaatggttc aacaccaaag tttgtaagag ccgaaccgaa gaatacagga gtaagctgac
     7141 cgttgcggac tgcttcaagg tcaaattcat cgcctgcacc gtcaagaagt tctatttcat
     7201 caaacaaatc ctgcttatga tagtagccta ttgtatcttc aagggcagga tcgtcaagcg
     7261 taagttcttt cttttcaact tctttctgac cgttattagc ggtgaaagca aggattttct
     7321 tggaatttct gtcatacaca cccttgaatt ccttacctga accgattggc cagtttacgg
     7381 gataggtgtg aattccgaga acattttcga tgtcttcaag aaggtcaaaa gaattttttg
     7441 catctctgtc catcttgttg atgaatgtaa tgataggaat attacgcatt acacagacct
     7501 taaaaagttt gatagtctgt ttctcaacac cctttgaacc gtcaattacc attacggcag
     7561 agtctgccgc cataagtgta cggtaggtat cttccgagaa atcctcatgt cccggtgtgt
     7621 caagaatatt tatgcaataa ccgttatatt taaactgcaa aaccgatgat gtaacagaaa
     7681 taccacgctg tttttcaatt tccatccagt cggacacagc atgctttgcg gttcttttgc
     7741 cttttaccga acctgcaagg ttaattgctc cgccgtagag caagagcttt tccgtaagtg
     7801 ttgttttacc cgcatcagga tgcgaaataa tcgcaaaggt tctgcgcttg ctgatttctt
     7861 ctttaaatga actcatatct ttcttccctt cggaggttaa gtgtatccac aattctatat
     7921 tttactattt ttggatggta tatgtcaata aagaatgaag aaaatgtgag aaaaataatt
     7981 gctacaaaaa cttgacaaat ttgtaaatat attgtaatat attggtacag aaggacttaa
     8041 tgtgattttt cctatttttt catatacctt ccaaatcgag gcagaaactt gtgtttctgc
     8101 ctcaaaatca tttatgaggt tttttatgag taactctatc ggtctttaca ttcacatacc
     8161 gttttgtaag cacaaatgtc cgtattgcga ttttttcagc gggaatgcag acgaaaacgc
     8221 tttcgataat tatgtgattg aattaaaaga taaaataaaa tactggtctg aaaaagccaa
     8281 aagagatgtt gctaccgtat atttcggcgg cggtacgccg agtgttttgg gtgcagacag
     8341 actttgtgat attcttgatt ttatcaagtt caattttaat attcaaaata atgccgagat
     8401 tacagttgaa gtcaatcccg actccgccaa aactattgat tttaaaaaaa tgtatgcctg
     8461 cggatttaat cgcatttcaa tgggtatgca gactgctgtt gaagatgaat taaggctgct
     8521 tgggagaatt cacagcatag atgacgcaaa aacttctgtt gaaagggcta aaagtgcggg
     8581 atttaataat atttcacttg atttgatgat gggaattcct aatcagacaa ttgaaagcct
     8641 tgaaaaatca atcagtttct gtgccgattg caaagttact catatttcat catacatttt
     8701 gaaaatcgag gagaatactc cgttttataa ggtgcaaaat aaacttaagc ttgccgatga
     8761 tgatatgcag gccgaaatgt atctgagagc tgttgaaaag cttgattctc tcggatacaa
     8821 gcaatatgaa atttctaatt ttgcaaaaca gggttatgaa agccgacata ataccaatta
     8881 ctggagatgc ggtgaatata tcggcatagg tccgtctgca cactcatttt ttgagggcaa
     8941 aaggtttttt tattcgagaa gcatggacga ttttaataac aataagctgt cttttgaagg
     9001 tacgggcgga gatgaggaag aatttattat gctctctctc aggctgaaaa gcggtcttaa
     9061 ttattctgaa tttgagaaaa aattcggata taccctcccc tcttacatta tcaaaaaagc
     9121 taaagagtat gaaaaatacg gctatacaaa tgttacagac aagtcaatca gctttacacc
     9181 gaaaggtttt cttgtttcaa attcaataat cagtgaactg atataaaaaa cgctccgaga
     9241 ataaattcgg agcgttaatt ttatgttatg aatttgtatg tcagattaat accatgaagg
     9301 gtatgaaccg ccgccgataa gcgatgtaag aacacttgtt gtaaatgtac ctgtgttaaa
     9361 tgaccacata gtaagttttg cgccgatgaa gaatataatc ataaatgcaa cggcaacgat
     9421 gagtgtgaga attaaagtga ataatgcaga gttctttgct tcgggaacat tagcttttac
     9481 ctgatttaca agtgaaataa caaggtaaag cattacgatt acgaagaaga acaggaacat
     9541 atatacgctg attaatgcgc taaggcctgc caaaatccaa ccgattgatg ccggaataga
     9601 ttcaattgaa aatgtgatga atgaatcaat aaatgctttg gctgtgtttt cttcggtttt
     9661 gtatttcttt acatatgcaa agagaataac agaatagaag ccaccgataa ggacagcagt
     9721 aacaagactt acaagaagtg ttttcggaaa atcaagtgcg ctcatagaaa gcataaggaa
     9781 catattgcca agaatgagtg caataaagaa aattgccgag aaaagagcgc cgagaatgat
     9841 gtccttttca gcctttgctg ttttgataac agttttggaa tccttaaaga atgaagtgaa
     9901 cacaacagga atgttcttta aagccttaac aaaagcattt tccccaatgg gtgctgtgtt
     9961 atttacggca taaggcgact gctgtgtctg agggttttgc ggctgtgtat actgttgctg
    10021 aacagggttc tgatactgtg gctgttgtgg atgaacaggc tgctgatact gagactgtgc
    10081 ctgtgcattt gcctgctgag cctgtgcttg agcggctctt gacttttcgc agttgcaaac
    10141 agcattgtct tcaagctgtg ctccgcaata tttacagaat ttcatggcga ttcctccaag
    10201 ataaaataat atgtaacagg tcttatagct acctgttgtt tgtttattga gaagtgataa
    10261 catcaacgct cacattatat cacaaattac agcaataatt caatatttct tacaattttt
    10321 taatttttta cactatagaa aattatatgt taaaataatg aaatgatgta cacatagcaa
    10381 ataatgacaa taaaacagcg gcaaaaacta taaactttag tttttgccgc tgtggtttag
    10441 taataatacc ttataaattt tatattgtag taatcacagg ttgtgatgtc gttggtgtca
    10501 atctcattta taaggatata atcctgagca acacctaaaa gatagcctgt tttctgaaca
    10561 attgtgtttg ctcccatgag aaaatcaacg gtgattcgtc ttccgatttg tgttcgcata
    10621 aaaccgttgt gatatctcag actttcggct gttacaggaa acggatattg ataatcactc
    10681 atcgacattc cgatattctg ccttatcggc gttgcaacgg tggctccgga gctcgccgtt
    10741 gtagcagggg ttgcaggcaa aacaggtata aatgtatcta ttttttttaa gtccttaatg
    10801 aacggtatat tttgaagact tccgctgtat ttatttatat tttcaggttg ttcttctgat
    10861 gtacttccgc cctcttcata tgctatttct gcctgttcaa gcgagggatt gtcatttgat
    10921 ttttgaactt tttctgtcat attggggtgt gcaacagacg gtgcgccctg attgtgtcgc
    10981 ataatttcgt caatcgcagg aatataacat ccgctatccg ctgtgtttga cggacatgaa
    11041 ttgttgaggc aggctttgtt tttgtcaagt ccgtaatgat gttcgggatt aatctgattt
    11101 gccgtaggag ttgtattaac tgccatattt gaagaattat ccattaagct atgctccttt
    11161 atgttttgga ataagcctcg gtaggcgaat aaaagcaatg atcccctacc ctgttgtaaa
    11221 ttactccgtt gtttgacgga aaaaatgttg ggcaggtatc tgaaaatgga ttaaaataga
    11281 aaattgaatt tccgacagat gaatcggtat tgcccgccaa tgcccaatcg gcaatgttat
    11341 agtgaatttc gtcagggcgt atattataaa cattctgagg attatattgt cctccgacag
    11401 ttgttttaag acaggtaaat tgatttggtt gttccattat ggcacggaaa tctccgccct
    11461 tgctgactct tgcaaattcc ccgtttggaa cacgggttcg gtttacaatt accgacgcaa
    11521 cggcacgcat tccgttttca ccttccccac ctgcctcaca ttttaaaagc cttgcaagca
    11581 attctcttgt actcaatgcc accttttttc accaaccgtt attttattca atgatatttt
    11641 atgcataaat taacttgttg ttacaaagaa aaagcttgtg ataaatgtgt tattcacgca
    11701 gacagaaaat tctgttttat agaagcaact cagacggtgt tcgataatct tttgagatgc
    11761 caactacaac atttattcag attagctgtt gctgtctacc gctttacttg cttttgcagg
    11821 gctattttgc caatcaccga accatcagat aaattgtttg ctttgagtaa tattattgat
    11881 tttttattga cactatcatc aatagtgcgt ataatgatat tggaacccga atttttaagt
    11941 tggctgggta attggtaccc tgacttctta aaaatattct gggttctttt tttgtctaaa
    12001 taaaaaaatc ctgttttccc tgttgtttct aaagcaacag tttctttgat taaatcattg
    12061 atgttgtttt tgccgtcatc gttcacaagc caatcatcgt attcttcgtc cattaaaaat
    12121 ttcagcgtat cgtgtattac actggctttt tcatctgtaa aatcataatc ttcatcaagc
    12181 gagaattttt cttttactcc tgcggaaagt tcttgcccaa tctcttgatt aactcctgct
    12241 ctgttggatt gtccttcatt aacttttcca tttttaacag agtttcgtcc gatgtcattg
    12301 aattgcttac tcttaatgtt gtattatccg agtataagtt caaactgttt agtataatct
    12361 ctgagtaatt gtctaaatac tttcttgcta tcataattgt tttcctctaa tttaattata
    12421 aaatttgcga ttttgttgcc atcggttata ttataatcta tatttcggat tgcataaacc
    12481 ttttctaaag gattatcgtc aaaagtattg tcgtagataa ctaatttgta ttgatacttt
    12541 gagtccactt cacactcaac aagaattgag ttatcattta ttcttaatcc cgaatcaagt
    12601 cctgttgaca tagcgtgcgt gaatttccgc cattcttctg ccgttaagac ttcagagaac
    12661 tttccaccgt gtttaggatt tatttcaaat cctaatatta ccaagttaga atgcaatgaa
    12721 tatcaaaaag aaatggtact gcaatcataa caggattttt agattatact tatcaataaa
    12781 tacagggcgt gaaaataatt agccactcat aaatatactc gattttttcg gattaccccc
    12841 cgactattga tattgagcaa aaaaacaccg taattctaac agaactacgg tgttttttat
    12901 ggcggagacg gtgggattcg aacccacgac cctcaggggg catcatgatt tcgagtcatg
    12961 tccgttatga ccacttcgat acgtctccga atattggtga tttaccttgt ttattgtact
    13021 tgttttttgt gtgattgtca agcaaaatta cacaaatttg taaattttaa atttaatccg
    13081 taaaagcata aataagtgtc tgcgattatt atatgaatac ttatgcttga ttttgcggac
    13141 atttttttga aaatcatgta cgaaaagatt attgaaacaa ccatactcaa attatcaatc
    13201 ggcacaactg cacttgcggg attgtcttgc aagactttgt aacagcagag tcatgaacag
    13261 ccctgttgca gcatatgaaa ggcagatata ggcaaattta tcttttggat tttatttaca
    13321 gcagacggtt ttccttttgc aaaaataagc aacctagcaa ttataagcaa cgcttatgcg
    13381 gattgctgtt ccgaaatttg attaagttcc ttctatgctt ttagggtgta ttttccgttt
    13441 ttgattataa caaaatcctt tgccataagt cggtgaagaa gttgcttcga ttttttatga
    13501 cttattccga gaagttcgga gatttctttt gaagttaccg taatgttgtc agtaatgtat
    13561 gaaattacgg catcctgtct gtctgtttca atatcgggac gattttgtaa aatttgagtt
    13621 ttagttgatt tgctttcagg aacaaacgaa agctttaggg tgatgctttc ggggttgaaa
    13681 ctttcttcaa tgaccggcag aacaagtttg tgacttttcc aaacggagaa aatattagaa
    13741 ataccgaagc cttcgttact gccgattcct atcaaattaa acatacgcat aattgcagta
    13801 tttctggggt cggatatacc gcccgctctt gcggcgtcga gttcaactct aaatccgcct
    13861 ggattggata ttgtaatgct ttcatcatct ttcataacaa caacaccgtt tgaaccataa
    13921 tagtcggcat ttataaggca gtttgcaaga gcttcctgta aggcagttgt aagcggtgta
    13981 atgtctgatt ttatgtttgc tgtcagtttt atatcgtatg aaattttttc aaagaccttt
    14041 ataaagaaat cataaaggtt ttcacagtca gaatttaaat ttgatgaaat aattgtgtgt
    14101 ttatcatctt gtgttgtttc cttatattca agacaatagg acgggtattc ttttttgatg
    14161 aactctgact taccgaacat aagaagtcct gcggctgtag ggtgaaacaa aaggtcttca
    14221 cctactccta ttgctcctat tgcctgcaag aaatctttat ccgacaaatt ttgaagccga
    14281 ttgtttggct taacatttga catttttatt cggtagctat ggagtgaatc ggtattaaat
    14341 acggaagcag tcatgctttc gatgatattc atatcctgtg ttttaatttc ggaatcacgc
    14401 accatagcgt taatttggtc gagtgtgcaa cggtagtcac cctcgccgtt tcttctgtat
    14461 gaattatgaa tactgccgtc aagatacaca ggacggtcaa atctttttgc ttttggcact
    14521 gtaataacga taatatgctt ttcttcaatt ttttgcacat aaacatcatc atatgaaaga
    14581 atgtttgtgc ttactttttg aatatcgttt gctatctccc aaaattcctc aataag
//
