LOCUS       gnlProkkaILHIEEAL_5    14184 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ILHIEEAL_5.
ACCESSION   gnlProkkaILHIEEAL_5
VERSION     gnlProkkaILHIEEAL_5
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 05:43:16
            Original ID  :: gnl|Prokka|ILHIEEAL_5
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14184
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14184
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3926:4184]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3927..4184
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14184
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14184
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             143..1363
                     /locus_tag="ctg5_1"
                     /transl_table=11
                     /translation="MRHKFYFLIQQITWVVFLFLTLFAVKTFERALPDEIYVPFGEKAD
                     YRFGVPVSVTLKDDSEEVFYRLNGQEDAVAEAPFYTVTCKLFGIFPVKDVKVMMVDRQE
                     VTAGGEAIGIYVKTDGILVLGTAKIADAWGNECSPAQNLVQSGDYIVSVNGETVCGKEE
                     LMDKIDSYGSGREIIGVMRKGEYVEVSMNPVKGETGKYRLGIWVRDDLAGVGTLTYYRQ
                     DGSFGALGHAVSDGDTGVQMSLSEGYIYETKIVSIQKGKKGVPGELAGIIDYGKSHCMG
                     SITENSPLGIRGMLNDTAGELEGEVYEVAYKQDIALGKAYIISEVSGERVEYEIEIESL
                     DYSGDEENKGILFKVTDERLLDLTGGIVQGMSGSPIIQNGKMIGAVTHVFVSDASMGYG
                     IFIEKML"
     CDS             1539..2906
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:diguanylate cyclase (Score: 140.4; E-value:
                     1.8e-42)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_2"
                     /transl_table=11
                     /translation="MLVQNALHLYKKCDDMLKYATALNLLGVIYGATGNETMAVDYLVE
                     GLECAIDYQLNNITTLFYNNIGSRYQELGEHEKAIDYFLKSARELQNPTCIKEERYRSW
                     ALITYLNLAVSYYELNLYELSYKYLEQAERQLDEEVEEMYHYTVLIFKCRLLWQMGKGD
                     YVYEYMEDLLASGEKDSNASDYLNDMKDLCQLFRDMKEYEYWKQTISAVETYTIDQKTV
                     FFQLFLTELWMDYYQTVGNEERYVELCVAHADLYKRQKAIDAKDRATAIDIKVQLREKE
                     AERKRVETMSVTDALTGLGNRYSLEREAVHIIRDAGGERITVGVLDIDCFKQLNDTYGH
                     IQGDRCLKVVADILKEAVMDCGHVYRFGGDEFVMLFPAGMENRIEEIAEAILQKIAEAG
                     IANEHSVVQPNLTISQGYACFVPEGTESGARLIEHADKALYYVKRNSRNAYYIIRE"
     CDS             2903..3016
                     /locus_tag="ctg5_3"
                     /transl_table=11
                     /translation="MMHILQLTTCFDKFSCVGISIISKQRVLSQEGLKWKN"
     CDS             3004..3801
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 89.4; E-value: 4.1e-27)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg5_4"
                     /transl_table=11
                     /translation="MEKLNVAIADDNERMLRLLGDIIESDDELNVVGVARDGEEAYHVI
                     KAKEPDVVLLDIVMPKLDGLGVLDRVSQDTSIKKHPAFIMISAIGQEKITEDAFARGAD
                     YYIMKPFDNDIVLSRIKNVRRPAAGRGAEVRKVNAYEKAEETKERNLEADVTDIIHEIG
                     VPAHIKGYQYLRDAIVMSVNDMDMLNSITKILYPTIAKKYQTTSSRVERAIRHAIEVAW
                     SRGKMDTIDEMFGYTIHNGKGKPTNSEFIALITDRIRLEYKMH"
     CDS             3927..4184
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_5"
                     /sec_met_domain="PF05402 (E-value: 2.3e-12, bitscore: 38.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.5e-09,
                     bitscore: 29.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKNRYQLRCAAGKYWLLDMEQDGETYRPPLMLNESGAYIFRQYM
                     AGNTADKIAEELATMYGGTADDMRTDVMQFIRQMELQGIL"
     CDS             4188..6359
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 62.7;
                     E-value: 6.3e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_6"
                     /sec_met_domain="RmlD_sub_bind (E-value: 5.3e-13, bitscore:
                     40.4, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILLVGSKCRFLQLLTDKLDKEGHRVFLLTAEDKSVRTSKKIFE
                     TYHFAYDNPCIREVLEGVRPDVTVFMGAYDTGFLWGKGSSTASAYTSGLFQLLMNETAG
                     NVGRFLYLSSEEVFGGEYTQDISCEENCAAYTVRAQAIAAGEELCRSYFNMGYETIVLR
                     LDHLYGEPLTGAEARDICARMSVEGLETGEIRVNPHNRVALLHYSDAVEFLYAVITAKK
                     MTYGVYQISSGETISVRSAAEFVAAELEGVKVVEDTGRERMDPVLSNQRFAEEFGIRIV
                     HKPETEIGREAAYIRQHASSFVRTQSRKKGWSRFGERSREAVRAMIPFAENLLCFLPFF
                     LLNNWMAGSAYFQNIDFYLLYVLLFAITYGQQQATFSSILAVAGYLAVQMYQRSGFDVV
                     LDVNTYIWIAQLLILGLVIGYMRDRLHAVEEEERHEVDFLSRQVEDISDVNGSNVRIKE
                     ILSNQIVNQNDSFGKLYEITSSLDKYEPSEVLFYAAEVLAKLMDSQDVAIYTVANHSYA
                     RLFSATSPKARMLGNSIHYVQMEEFYEKLREKKVFINKTMDERYPLMADAIYSEDEMQL
                     ILMVWGIPWERMTLGQANMLTVIGYLIQNAVVRANRYLSALEQQRYIHGTRILEADAFA
                     SLVKAYLNAREKKLTECALVVFEEGETSREEAAGVLSGMMRQSDYLGELSDGKMYALLA
                     NTSAEDAGMVVERFRSAGFPCRMKEEMEL"
     CDS             6356..7273
                     /locus_tag="ctg5_7"
                     /transl_table=11
                     /translation="MSRIETYFLLLVVLNLCITAAYVLWNEQHWREEPGKRTGGRIRAA
                     VMLLAPVIGPVFFVAGELARHLLFGQSADLEDVIFSKERVRTHFMADEEQERNVVPIEE
                     ALAISDRDSLRTLIMNVVRGDVTDSLGSLALALDSEDTETSHYAASVLRDVLNDFRQHA
                     QKLYRQMQKDGREAGDDACLLIEYMYVVLKQNVFHETEQRTFVDMFEEACELLYEKDYR
                     KLTAQYIEWLCELLLRLKEFGRMHYWCNRSRELYPDALSTYTCYLKMYFTQEKKTEFFR
                     ELDRLKASNIVIDRETLELIRTFS"
     CDS             7294..9174
                     /locus_tag="ctg5_8"
                     /transl_table=11
                     /translation="MVSRRNYLTIAMMFVILLFMFQFTGVMKEQLSEYESNEYADDTTT
                     SFQRSDAFLAEQTSADACEVIYVGEAGGAEESVVKTWCSYRKRTFFCSSSLALLDSLQD
                     DVLQVLVVDGSKVTSEEEVAVLRREAQMGVTVIFATLPQSSVIREYRDLRELLGIRAVI
                     ADEIPLAGMHLFSGFLLGGEEIYEVTELGEEERQDMNPSVPWYTTGAGTKTYMVGTLSD
                     ETIEQTVDNEIRAQYAGMEEEAAKNSLLPAILWRNSVDTAKIFCVNGDYLADISAVGIL
                     DAMMGETYDYDIYPVINAQNLVIADLPAFVSENEEEMQKRYSQSAQAVYQEIVWPSLTS
                     IASRTGAKMTCMMTPQFTYTDEEEPDGENVTYYLKRLKEEHAEAGLSADSMEGIPLSEK
                     IKQDQTFWQTYAPSYRFLSLYADGVKSIGEKSALPAEIRTVALGSGASGQAVGYLNENV
                     TLQPSTSSGIRHTFLDDFKVKCMETALGYSNITLDFYSVTYPEGDEDSWEKMSKKIAAN
                     LGTYWKAYEAFDATTLTESDVRIRRFLALDYKQQRAGNVITLSLEHREDAAWFLLRLHG
                     EKVTEVAGGIFEEIEDGVYLILAEEDEVSVEVQTGETWQYQDGGKRGDGT"
     CDS             9171..10595
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 123.8;
                     E-value: 1.7e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_9"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.9e-23,
                     bitscore: 74.1, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRICIVAEGCYPYVVGGVSSWIHSMIKIFPEYQFVVLAIVANRSL
                     RGKFVYDLPENVVEVHELYLEDADWRPKELKRAARLKLNEREYAALRSLLMNQNVDWDT
                     LFSFFGEKEFSLNELLMGEDFFRAVQECYTVRYAGAVFSDFLWTMRSMYLPLFLTLGMR
                     LPRADVYHCVATGYAGVLGSMAKRRFGCRLLISEHGIYTREREEELIRADWVSGIYKNI
                     WIEQFKKMSKLAYDRADLVTSLYAHARELQIELGCPADKTSITPNGIDPARFDGLKRPE
                     AMEPDMVHIGAVLRVTPIKDVKTMIRAFAYAKRDVPNLKLWIMGPTEEDEEYARECFEL
                     VELMELPDVVFTGRVNVTEYLGGLDFTILTSISEGQPLTVLEGYAAKLPAIATDVGNCR
                     GLLYGEDDDFGEAGILTHIMNVKEIADAMVNLARHPVRRKQMGENGYRRVMAKYKISDM
                     QQTYRKIYETFENIDW"
     CDS             10610..12061
                     /locus_tag="ctg5_10"
                     /transl_table=11
                     /translation="MAGIGIKLQKIYEKKTILAYLTGFGYSAVVTVAPMFVVIGTIMLM
                     SQLLGYENVGYARRGLFSGTLLYIFIFSLLTAAPFNAVLSRYMSDVIYEERYEDILPCY
                     DVGLLLNILLASLLGIPFCAWEHLVGHVNLIFVFTGFCGYIALVLVFYSMLYLSICKDY
                     QKISLYFLTGMAAALACALFFVKVCGREIVYSMLLSLTIGFFLTAVLEYATVKRYFKRN
                     SNRYRRVFSYFGRYWKLVVINFLYTLGLYIHNFVFWNTDLQMRVADTFVFAPTYDLATC
                     LAMFTNLSSTIIFITRVEMHFHTRYKAYSEAVIGGRWEDIKNTKDRMFRQLSAELMNLV
                     RIQFIISTAVYLLCVVGLPQYGFSGRVMQIYPCLAAGYFILFILYAEIIFLYYFNDLTG
                     ALLATLGFCLVTWAGSMLSAGGSDLWYGMGLVAGSFTGFTIAYFRLRFMERHMDEHIFC
                     GGQLFTVKRERMPESMVYTKKQKER"
     CDS             12065..12445
                     /locus_tag="ctg5_11"
                     /transl_table=11
                     /translation="MNVILILRIFLTAAGVLFLLGDINAYVRQKLTDTIGLLWAFVSVA
                     LILTGVVSVPGAREEEYLVVLLLAVCLLLLILLFKLSKVVSVLSMKNQELAMQVSLLNQ
                     ENERILHRLGILTDEKKDIVRD"
     CDS             12417..13646
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 99.8;
                     E-value: 3.2e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_12"
                     /sec_met_domain="Glycos_transf_1 (E-value: 5.2e-25,
                     bitscore: 79.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKILFVINTLSRAGAETALLELLAQLAAERGEDGQPRYELSLF
                     VLMNQGELVQQIPEGVRLVNPRYAPVSVLEPKGRIYMGMTVVKCLLHRANLIRLWRYHW
                     RAARAMRKEGRLMPDKLLWRAISDGARRFPEEYDLAVAFLEGGSAYYVADHVRAKKKAA
                     YIHIDYQKAGYSRELDRDCYLQYDAVFPIGEQVKRAFLAVYPECSARTRIYHNRIDCEK
                     IRKMSVQPGGFTDDFDGIRLLTVGRLTPQKAYPVAIEAMRQLKAEGYPVRWYVLGEGSS
                     RRELEQYIASCGLKEDFLLLGAVTNPYPYYRQTDIYVHATGYEGKSIAIQEAQTLGCAI
                     VASECNREQITDGEDGILCALDAAAVKEAVGFLIRNPDRRRAYAQAALKRPVNYENEER
                     LLEQLLSEKE"
ORIGIN
        1 tgaacgaaga gaaagtctag ggcgccttga gacgctgtcg ggtaccaagg ggttacaccc
       61 agcgtcccga gccacccttt ttaagggtgg cggcgacttg tgtggcggcc tttgggttac
      121 agaaaatggt atgggggcag atatgagaca taaattttat tttttgatac agcagatcac
      181 gtgggttgtt tttttgtttt tgacgctgtt tgccgtaaag acgtttgagc gggcactgcc
      241 ggatgagatc tacgttccgt tcggggaaaa ggcggattac cggtttggcg ttccggtgag
      301 cgtgacgtta aaggacgaca gcgaggaagt gttctaccgc ttaaacgggc aggaggatgc
      361 cgtggcggag gccccttttt ataccgttac ctgcaagctg ttcggcattt tcccggtaaa
      421 agacgtgaag gtgatgatgg tcgacagaca ggaggtgact gcgggcggcg aggcgatcgg
      481 tatctatgtg aagacggacg gaatcctggt gctcggcact gcaaagattg cggatgcgtg
      541 gggcaatgag tgcagcccgg cgcagaatct ggtgcagagc ggggattata ttgtgagcgt
      601 gaacggggag acggtgtgcg ggaaagagga gctgatggac aagattgaca gctacggcag
      661 cggacgtgag atcatcggag tgatgcggaa gggggagtat gtggaagtat ccatgaatcc
      721 ggtcaaaggc gagacgggaa aataccgcct tggaatctgg gtgcgggatg atcttgccgg
      781 ggtcggaaca ctgacctact acaggcagga cggcagcttt ggcgcactcg gacatgcggt
      841 gagcgacggc gacaccggcg tgcagatgag cctgtcggaa ggatatattt acgagacgaa
      901 aatcgtcagc atccagaagg ggaagaaggg cgtcccgggc gaacttgcgg ggatcattga
      961 ctacgggaaa tcgcattgca tgggaagcat tacggagaac tcgccgcttg gcatccgcgg
     1021 catgttaaat gatacggcgg gagaactgga aggagaagtc tacgaggtgg cttataagca
     1081 ggacattgcg cttggaaaag cctacatcat ctcggaggtg tccggggagc gcgtggagta
     1141 tgagatcgag atagagagtc ttgattacag tggggatgag gaaaacaagg gaatcctttt
     1201 taaagtcacg gatgagcggc ttttagacct gaccggagga atcgtacagg ggatgagcgg
     1261 cagtccgatt atccagaacg gaaagatgat cggggcggtg acgcatgtgt ttgtgtcgga
     1321 tgcgtcgatg gggtacggaa tctttattga gaaaatgttg tgattgtacg acaaaaactt
     1381 ttacaacgtc tggtacttat ggtatactac agtcagtatt gttggcttta aggacggaag
     1441 atggaatgga acagcaggaa catatacaaa aactggcaga tgaatactac gaagagggca
     1501 gagccagatt ctttgaccac aagctggagg aagcggcgat gcttgtacag aatgcgcttc
     1561 atctctacaa gaagtgcgac gacatgttaa aatacgccac agcgctcaat ctgctcgggg
     1621 tgatctacgg cgccacgggg aacgagacga tggcggtgga ttatctggtc gaaggacttg
     1681 agtgtgcgat cgattaccag ctaaataaca tcacgacact cttttataac aatatcggct
     1741 ccaggtacca ggagctggga gagcatgaga aggcgatcga ctatttctta aagtcggcgc
     1801 gggaactgca gaatccgacc tgcatcaagg aggaacgcta ccgttcctgg gctctgatta
     1861 cctacctgaa tctggcggtc tcctactatg aactgaacct gtacgagctt tcctacaaat
     1921 atttagagca ggcagagcgg cagcttgacg aggaagtgga ggagatgtat cattatacgg
     1981 tgctgatctt caaatgtagg ctgctctggc agatgggaaa gggggactat gtgtatgagt
     2041 acatggagga ccttctggcg agcggtgaaa aagacagcaa tgcgtcggat tatctgaacg
     2101 atatgaagga tctgtgtcag ctgttccgcg acatgaaaga gtatgaatac tggaagcaga
     2161 ccatatctgc ggtcgagacc tatacgattg atcagaaaac cgtctttttc cagctgtttc
     2221 tgacggaatt gtggatggac tactatcaga ctgtggggaa cgaagagcgc tatgtggaac
     2281 tgtgtgtggc acatgcggat ctgtataagc gccagaaagc gatcgatgcg aaggaccgcg
     2341 ccacagcgat cgacatcaag gtccagctgc gggaaaaaga ggcggagcgc aagcgcgtgg
     2401 agactatgtc tgtgacggat gcgctgaccg ggctggggaa ccgctattct cttgagcgtg
     2461 aggcggtgca tatcataagg gatgcgggcg gtgagcggat cacggtcggc gttttggaca
     2521 tcgactgctt taagcagctg aacgatacct acggacatat tcagggagac cgctgcctga
     2581 aggtggtggc ggatattctg aaggaggcag tgatggactg cggacatgtc taccggtttg
     2641 gcggggatga gttcgtgatg ttgtttccgg cagggatgga gaaccggatc gaggagatcg
     2701 cggaggcgat cctgcagaag attgcggagg cgggaatcgc aaacgagcac tcggttgtac
     2761 agccgaatct tactatctcc caggggtatg cctgctttgt gccggagggc acagagagcg
     2821 gagcgcgtct gattgagcac gcggacaagg cgctttacta tgtgaagaga aacagcagaa
     2881 acgcatatta tatcatacgc gaatgatgca tatacttcag ttgacgactt gcttcgacaa
     2941 attttcttgc gttggaatca gtatcatcag taagcaaaga gttttgtcac aggaggggct
     3001 aaaatggaaa aactgaatgt tgcaatagca gatgataatg agagaatgct gcgattatta
     3061 ggggatatta tcgaaagtga tgacgaactg aatgttgtag gagtcgcccg cgacggcgag
     3121 gaagcatacc atgtgataaa ggcgaaagaa ccggatgtcg tgctgctcga cattgtgatg
     3181 ccgaagcttg acggattggg ggttttagac cgcgtgagtc aggacacctc cataaaaaaa
     3241 catccggcgt ttattatgat cagcgcgatc ggtcaggaga aaatcacgga agatgcgttt
     3301 gcgcgcggcg cagattatta cattatgaag ccgtttgaca atgatatcgt gttaagccgc
     3361 atcaagaatg tgagaagacc tgcggcggga cgcggtgcgg aagtgcgcaa ggtcaatgcc
     3421 tatgagaagg cggaggagac aaaggagcgc aacctggaag cggatgtcac cgatattatt
     3481 cacgagatcg gagttccggc gcatatcaaa gggtatcagt atctgcggga tgcgattgtc
     3541 atgtccgtca atgacatgga tatgctcaac tcgatcacga aaattcttta tcccacgatc
     3601 gcgaagaagt accagacaac ctccagccgt gtggagcggg caatccggca tgcgatcgag
     3661 gtggcgtgga gcagaggcaa gatggatacc attgatgaga tgttcgggta taccatccac
     3721 aacggaaaag gaaaaccgac gaattcggag tttatcgcac tcattaccga ccggatacgt
     3781 ctggaatata agatgcatta atgatgagga catatttttc aggaggcgca aagccgaaga
     3841 agagtatgtc ctcattttcg gataaccggt tccttttgag cgtcagatgt gctataatta
     3901 tacgatgatt tttcggagga tggcagatgc agaaaaacag gtatcagctc aggtgcgcgg
     3961 caggaaaata ctggctgtta gatatggagc aggatggaga aacgtatcgg ccgccgctca
     4021 tgttaaatga gagcggggct tatatcttca ggcagtatat ggcaggaaac acggcggata
     4081 aaatcgcgga ggagcttgcc actatgtacg gggggaccgc agacgatatg cggacagatg
     4141 tgatgcagtt tatcagacaa atggaactac aggggatctt gtaaacgatg aatatattat
     4201 tggtgggaag caaatgccgc ttccttcagc ttttgacgga caaactggac aaagaagggc
     4261 accgtgtgtt tttgctgacg gcagaagaca aatcggtcag aacgtccaaa aagatatttg
     4321 agacgtatca ttttgcatac gacaatccgt gcatcagaga ggtgcttgag ggagtgcgtc
     4381 cggatgtgac agtctttatg ggcgcctatg atacaggctt tctctggggg aaggggagca
     4441 gcacggcgtc ggcgtacact tcaggcctgt ttcagctgct gatgaatgag acggctggta
     4501 atgtgggacg ctttttgtat ctctcgtcgg aggaagtctt cgggggagag tatacacagg
     4561 acatttcgtg cgaggaaaac tgtgcggctt atacggtacg cgcgcaggcg attgcggcgg
     4621 gagaggaact ctgccgcagt tactttaaca tgggctatga gacgatcgtg ctgcggctgg
     4681 atcatctcta cggggaaccg cttaccgggg cggaagcgcg tgatatctgc gcccgcatga
     4741 gtgtggaggg gctggaaacc ggtgagatcc gggtaaatcc ccacaaccgt gtggcgctgt
     4801 tacactattc ggatgccgtc gaatttttgt atgcggtgat tacggcaaaa aagatgacgt
     4861 acggcgtcta tcagatttct tccggagaga cgatttccgt gcgaagcgca gcggagtttg
     4921 tggcggcgga actggaaggt gtgaaagtcg tagaggacac cggaagagag cggatggatc
     4981 cggttttgtc caaccagaga tttgcggagg agtttgggat acgcattgta cataagccgg
     5041 agaccgagat tggcagggag gcggcgtaca tccggcagca cgcatcttct tttgtgcgga
     5101 cacagagcag aaaaaaggga tggagccggt tcggagagcg gtcgagagag gccgtaagag
     5161 cgatgattcc gttcgcggag aatctgcttt gtttccttcc gtttttcctg ttaaataact
     5221 ggatggcggg gagcgcgtat ttccagaaca ttgattttta ccttctgtat gtgctgctgt
     5281 tcgccattac ctacgggcag cagcaggcga cattctcctc gattcttgcg gtggcggggt
     5341 atcttgcggt gcagatgtat cagcggagcg gttttgatgt ggtgctggat gtcaacacgt
     5401 acatatggat tgcacagctg ctgattctgg gacttgtgat cggctatatg cgcgaccggc
     5461 tgcatgcggt ggaggaggag gagcgccatg aggtggattt cctctccaga caggtagagg
     5521 acatctcgga tgtcaacggc agcaacgtgc gcatcaagga gattctgtca aatcagatcg
     5581 tcaaccagaa cgacagcttc ggaaagctgt atgagatcac gtccagcctg gacaagtacg
     5641 agccgagtga agtgttgttc tatgccgcag aggtgctggc aaagctgatg gacagtcagg
     5701 atgtcgcaat ctatacggtg gcaaaccact cctatgcgcg tctgttctcg gcaacttcgc
     5761 cgaaggcacg catgctcgga aattccattc actatgtgca gatggaagaa ttctatgaaa
     5821 agctgcggga gaaaaaagtg ttcatcaaca aaaccatgga tgagcgctat ccgctgatgg
     5881 cggatgccat ttattcggag gatgagatgc agctgattct gatggtgtgg ggaatcccat
     5941 gggagagaat gacgctcgga caggcgaata tgctcactgt gatcggctat ctgatccaga
     6001 acgcggttgt acgtgcgaac cgttatctct cggcgttaga acagcaacgc tatatccacg
     6061 gcaccagaat tttggaggcg gatgcgtttg cttctctggt gaaggcttat cttaacgcca
     6121 gggagaagaa gctgacggag tgtgcgctcg tcgttttcga ggagggtgag acctccaggg
     6181 aggaagccgc gggcgtcctt tccggcatga tgcgccagag tgattacctt ggagaactct
     6241 ccgacggaaa gatgtacgca ctgcttgcta acacgagcgc agaggatgcg ggaatggttg
     6301 tggagcgttt taggagcgca ggctttccgt gcaggatgaa agaggagatg gaactatgag
     6361 caggatcgaa acgtattttc tgctgcttgt ggtactgaat ctgtgcatca cggcggcgta
     6421 tgtcctgtgg aatgagcagc actggagaga agagcccgga aagcgcaccg gcggaagaat
     6481 ccgcgcggcg gttatgcttt tggcaccggt gatcggtccc gtcttctttg tggcgggaga
     6541 actcgcgcgg catcttttat tcggacagtc ggcggatctg gaagatgtta ttttcagtaa
     6601 ggagcgtgtc agaacacact ttatggcgga tgaggagcag gagcggaatg tggtgccgat
     6661 cgaggaggca ctggcgattt ccgaccggga tagtctgcgc acactgatta tgaatgtggt
     6721 cagaggagat gtcacggact ctctcggatc gctggcgctg gcacttgaca gtgaggacac
     6781 cgagacctcc cactatgcgg cgtcggtgct tcgggatgtg ctcaacgatt tcaggcagca
     6841 tgcacagaaa ctctaccggc agatgcaaaa ggacggcaga gaggcggggg atgatgcctg
     6901 ccttctgatc gagtacatgt atgtcgtctt aaaacagaat gtttttcacg agaccgaaca
     6961 gcggacattt gtggatatgt ttgaggaggc gtgtgaactt ctctatgaaa aagattaccg
     7021 gaaactcact gcgcaataca tcgaatggct gtgtgaactg ctgctccgct taaaggaatt
     7081 cgggcggatg cattactggt gcaaccggag ccgggaatta tatccggatg cgctttccac
     7141 gtacacctgc tatttgaaaa tgtattttac gcaggagaag aaaaccgaat ttttccggga
     7201 actggatcgg ctgaaagcgt ccaatatcgt cattgacagg gagacgttag agctgatccg
     7261 gacgttcagt tagtccggca ggaaggaaat gacatggtat cacgcagaaa ttatctgacg
     7321 attgcaatga tgtttgtgat tctgcttttt atgtttcagt ttacaggcgt catgaaagaa
     7381 cagttaagtg aatatgagag caacgaatat gcagacgata ccacaacatc ctttcaacgg
     7441 tcggatgcat ttctggcaga acagacatct gccgacgcct gcgaggtgat ctatgtgggc
     7501 gaagcagggg gagcggagga atccgtggta aagacatggt gcagctaccg caagcggacg
     7561 tttttttgca gcagctccct cgcactgctt gacagcctgc aggatgatgt actgcaggtg
     7621 ctggtggtgg acggcagcaa ggtgacgtcg gaagaagagg tggcggtgct tcgcagagag
     7681 gcacaaatgg gtgtgactgt gatttttgca accctgccgc agagctctgt gataagggag
     7741 taccgggatt taagggagct tctcggaatc cgcgcggtga ttgcggatga gataccgctt
     7801 gcgggcatgc atctgttttc cggctttctg ctcggcgggg aagagatcta tgaggtcacg
     7861 gaactcgggg aggaggagcg tcaggacatg aacccttctg ttccctggta tacgaccggc
     7921 gcgggaacca agacctatat ggtcggcacg ctgtccgatg agacgatcga acagacggtg
     7981 gataacgaaa tacgggcaca gtatgcggga atggaggaag aggcggcaaa aaacagcctt
     8041 ctgcctgcca ttctctggag aaacagcgtg gatacggcaa agattttctg tgtgaacggg
     8101 gattatcttg cagacataag cgctgttgga atactggacg ccatgatggg ggagacatac
     8161 gattacgata tctacccggt aattaacgca cagaatcttg tgattgcaga tctgccggcg
     8221 ttcgtctccg agaacgagga ggagatgcag aagcgctaca gtcagtccgc acaggcagtg
     8281 tatcaggaaa ttgtgtggcc gtcgctgacc tccattgcct cccggacggg ggcaaagatg
     8341 acctgcatga tgacgccgca gtttacgtat acggatgagg aagagccgga tggagagaac
     8401 gtcacctatt acctgaaacg tctgaaggag gagcacgcgg aggcgggact gtccgcagac
     8461 agcatggaag ggatcccgct ctcagaaaaa ataaagcagg atcagacgtt ctggcagacc
     8521 tatgcgccgt cctaccggtt tttatccctc tacgcggacg gagtaaagag catcggggag
     8581 aagagtgccc ttccagcgga aatccggacg gttgcgctcg gatccggcgc cagcgggcag
     8641 gcggtggggt atctcaatga gaacgtcaca ctgcagccgt cgacgagttc cggaatccgg
     8701 catacgtttc tggatgattt taaagtgaaa tgcatggaga cggcgctcgg ctattccaac
     8761 atcacactcg acttctatag cgtgacttat ccggaagggg acgaggattc ctgggagaaa
     8821 atgtccaaga agatcgcagc aaacctgggc acctactgga aagcgtatga agcgtttgac
     8881 gcaaccaccc tgacagagag tgatgtgcgc atccgcagat ttctggcact tgactataag
     8941 cagcagcgcg cgggcaatgt gattacgctt tccttagagc accgggagga tgcggcatgg
     9001 tttctgctgc gcctgcacgg agagaaagtc acagaagttg cgggcggaat ctttgaagag
     9061 atagaagacg gcgtctacct gattcttgca gaggaagatg aggtctccgt ggaagtgcag
     9121 accggggaaa catggcagta tcaggacggc ggaaagcgtg gtgacggcac atgagaatat
     9181 gtattgtggc agagggatgc tatccctatg ttgtcggggg tgtatcgagc tggatacaca
     9241 gtatgataaa aatatttccg gagtaccagt ttgtcgtgct ggcgattgtg gcgaaccgtt
     9301 cgctgcgcgg aaagtttgtc tacgatctcc cggagaatgt ggtggaagtg cacgaactgt
     9361 atctggagga tgcagactgg cggccaaaag aacttaaaag agcagccaga ctgaagttaa
     9421 atgagcggga gtacgccgca ctgcggagcc tgttgatgaa ccagaatgta gactgggata
     9481 ccctgttctc ctttttcggg gagaaggaat tctctttgaa tgaacttctc atgggggagg
     9541 attttttccg ggcggtgcag gaatgttata cggtgcggta tgcgggggcg gtgttttctg
     9601 atttcctctg gacgatgcgc tccatgtatc ttccgctgtt tctgacactt ggcatgcggc
     9661 tgccgagggc ggatgtgtat cactgtgtgg cgacgggata tgcgggcgtg ctgggcagca
     9721 tggcaaagcg caggtttggc tgcaggcttc tgatctcgga gcatggaatc tacaccaggg
     9781 agcgcgagga agaactgatc cgtgcggact gggtgtccgg catctataaa aatatctgga
     9841 ttgagcagtt caagaaaatg tcgaagcttg cctatgacag ggcggatctg gtgacaagcc
     9901 tttacgcgca cgcgagagag cttcagatcg aactgggatg tcctgcggat aagacgagca
     9961 ttaccccgaa tgggattgat ccggcgcggt ttgacggttt gaagcgtccg gaagcgatgg
    10021 agccggatat ggtgcacatc ggtgcggtac tccgcgtgac gccgatcaag gatgtcaaga
    10081 ccatgatccg ggcgtttgcg tatgcaaagc gcgatgtgcc taacttaaaa ttatggatca
    10141 tggggccgac ggaagaagac gaggaatacg cgagagaatg ttttgagctg gtggagctga
    10201 tggaactgcc ggatgtggtg tttaccggaa gggtgaatgt gacggaatat ctcggcggac
    10261 tggattttac cattctgacc agtatcagcg aggggcagcc gttaacggtt ctggagggct
    10321 atgcggcgaa gcttccggcg atagcaaccg atgtcggaaa ctgccgcgga ctgttgtacg
    10381 gcgaggacga tgattttggc gaggcgggaa ttttgacgca catcatgaat gtgaaggaaa
    10441 ttgcggatgc catggtgaat cttgccagac atccggtccg cagaaaacag atgggagaaa
    10501 acggttaccg ccgtgtgatg gcaaagtaca agatttcgga tatgcagcag acgtaccgga
    10561 agatttatga aacgtttgag aacatagact ggtagaaggg agagagactg tggcaggaat
    10621 aggaatcaag cttcagaaaa tatatgagaa aaaaacgatt cttgcatatc tgaccggatt
    10681 cggctacagt gcggtcgtga cggtcgcacc gatgtttgtc gtgatcggaa cgatcatgct
    10741 catgagtcag ctcctgggat atgagaatgt gggatatgcg agaagaggac tgttttccgg
    10801 aacgctgctt tacatcttta tcttttcgct tctgacggcg gcgcctttta atgcggtgtt
    10861 gtcccgctat atgtcggatg tcatctatga ggagcgctat gaggatattc tgccctgcta
    10921 cgatgtgggg ctgcttttaa acattctgct ggcaagtctt ctcggaattc cgttttgcgc
    10981 atgggaacat cttgtgggac atgtcaacct gatttttgtg tttaccggat tttgcggtta
    11041 tatcgcactg gttctcgtgt tttattcgat gctttacctc tccatctgta aggattatca
    11101 gaagatatcg ctgtactttt tgaccggaat ggcggcggca ctcgcctgcg ccctcttttt
    11161 tgtaaaagta tgcggtaggg agattgtcta cagtatgctg ctttccctca cgatcggatt
    11221 ctttcttacg gcggtgttgg aatacgccac ggtgaagcgg tattttaaga ggaacagcaa
    11281 ccggtacaga agagtttttt cgtattttgg caggtactgg aagctggtgg tgatcaattt
    11341 tttgtatacc ctcggtctgt atattcataa ttttgtgttc tggaatacag atttacagat
    11401 gcgcgtggca gatacgtttg tctttgcccc gacgtatgat ctggcaacct gtctggcgat
    11461 gtttacgaat ctgtcgtcga ccatcatttt tatcacgcgg gtagagatgc atttccacac
    11521 acgttacaag gcgtattcgg aagcggttat cggaggaaga tgggaagata tcaaaaatac
    11581 aaaagacaga atgttccggc agctttctgc ggagcttatg aatctggtgc gcatacagtt
    11641 tatcatctcg acggcagtgt atctgctctg cgtggtgggg cttccgcagt acgggttctc
    11701 gggaagagtg atgcagatct atccttgtct tgccgccgga tattttatat tatttattct
    11761 gtatgcagaa attatttttc tgtactactt taacgatctg acaggggcgc ttttggcaac
    11821 cctcggcttt tgcctggtga cgtgggcggg aagcatgctt tctgccggcg ggagtgatct
    11881 ttggtacggc atggggctgg tggcgggcag ctttaccggc tttaccattg cctatttcag
    11941 actcaggttc atggagcgcc atatggatga acatatcttc tgcggcggac agctgtttac
    12001 ggtgaagaga gagcggatgc cggagagtat ggtatataca aagaaacaga aggagcgtta
    12061 gtatatgaat gtgattttaa ttctgcggat ttttctgacg gcagcgggag tgttgttcct
    12121 tttgggggac atcaatgcgt atgtgagaca aaaactgacc gatacgattg gacttctgtg
    12181 ggcatttgtc tcggtggcgc tgattttaac gggcgtggtc tccgtgccgg gggcaaggga
    12241 ggaggaatac ctggtggtgc ttcttctggc agtctgcctg ctgcttttga tcctgctgtt
    12301 taagttaagc aaggtggtgt cggttctttc catgaaaaat caggagcttg ccatgcaggt
    12361 ttccctgctc aatcaggaaa atgagagaat attgcacagg ctggggattt tgacagatga
    12421 aaaaaaagat attgttcgtg attaatacat taagccgcgc cggagcggag acggcactgt
    12481 tggaactgct tgcgcagctt gctgccgaga ggggggaaga cgggcagccc agatatgagc
    12541 tctcgctctt tgtcctgatg aaccagggag aactggtgca gcagatacca gagggggtgc
    12601 ggcttgtcaa tccaaggtat gccccggtct cggtgctcga accaaaggga agaatctata
    12661 tgggcatgac cgttgtaaaa tgtctgcttc acagagccaa cctgatccgg ctgtggcgct
    12721 atcactggag ggctgcgcgg gcgatgcgca aagagggacg gctgatgccg gacaaactgc
    12781 tgtggcgggc aatctcggat ggcgccagac gcttcccgga ggaatatgat cttgcggttg
    12841 cattcctgga gggtggttct gcatactatg tggcagacca cgtcagggcg aaaaaaaagg
    12901 cggcgtatat tcatatcgac tatcagaagg cgggatacag cagggaactg gaccgcgact
    12961 gctacctgca atatgatgcc gtatttccga tcggggaaca ggtaaaacgg gcgtttctcg
    13021 ccgtgtatcc ggagtgcagt gcacgcacca ggatctatca caatcggatc gactgtgaaa
    13081 aaatccggaa gatgtccgtg cagccgggag gatttacgga tgatttcgac ggaatccgcc
    13141 tgcttacagt gggaagactc accccgcaga aggcatatcc ggttgcgatc gaagcgatgc
    13201 ggcagttaaa ggcggaggga tacccggtcc ggtggtatgt gctgggcgag ggaagcagcc
    13261 gcagggaatt agagcagtac attgcgtcgt gcggattaaa ggaggatttc ctgctgcttg
    13321 gagcggttac aaatccctat ccgtactacc ggcagacgga tatctatgtg catgcgaccg
    13381 gatatgaggg gaaaagcatt gcgatacagg aggcgcagac gcttggctgt gcaatcgttg
    13441 cttccgaatg taacagagag cagattacag acggggagga cgggattttg tgcgcgcttg
    13501 acgctgcggc ggtaaaggaa gctgtgggct tcctgatccg gaatccggac cggcgcaggg
    13561 cgtacgcgca ggcggcgtta aagcgtcctg taaattacga gaacgaggaa cggctgttgg
    13621 agcagctgct ttccgagaaa gaataaggaa gatacgatgg tagagaagaa acagaaagaa
    13681 ctgctgatta tcattccggc atacaatgag gagaaaaata tagagcgggt gctggaggag
    13741 ctggaacgcc cggagatcgc ggagattgcg gatattctgg tcatgaatga cgcgtcctcg
    13801 gactctacga actgggtcgt aaaggcacac ggacatacgc tggtatccca tgtctttaat
    13861 ctggggtacg ggagcgccct gcagcttgga tataaatacg cgatccgccg caaatattcc
    13921 tatgtgatcc agatggatgc ggacggacag catgatgtgt gcaacatacc ggtgatctat
    13981 cagagactaa aacagcagga tgcggacgga cgctgcccgg atatcgtgct ctgttcgcgt
    14041 tttatggagg gaagtgcaga gtatccggtc tccgctacga agaaactggc atacggattc
    14101 ttccgctgga tgataaagat cagtaccgga cgaaagattg ccgatccgac gaccggtctg
    14161 cagggactta accgcagggc attt
//
