LOCUS       c00062_gnlPro..        12398 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ILHIEEAL_62.
ACCESSION   c00062_gnlPro..
VERSION     c00062_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 01:28:32
            Original ID  :: gnl|Prokka|ILHIEEAL_62
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12398
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12398
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5532:10820]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5533..10820
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..12398
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12398
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(2..535)
                     /locus_tag="ctg62_1"
                     /transl_table=11
                     /translation="MNVILAKSAGFCFGVKRAVDMVYERILEKEPLYTFGPIIHNEEVV
                     RDLEEKGVVVVNDVDELAGKPQGTVIIRAHGVERGVCEKIQTLGFSIVDATCPFVLKIH
                     RLVERYSGEDCHIVIVGNASHPEVKGIKSWSNAEDTRVIGTREEAEKYDASHGKKVCIV
                     SQTTFNYNKFQELVE"
     CDS             complement(541..1203)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg62_2"
                     /sec_met_domain="Cytidylate_kin (E-value: 5.1e-81,
                     bitscore: 261.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMNIAIDGPAGAGKSTIAKKLAKKLAFVYVDTGAMYRAMAYYFL
                     QNGIAPDDEQAIAAACPKVDVTIVYENGEQQVLLNGENVNGVIRTEEVGNMASATSVYP
                     VVRTKLVELQRQLATKTDVIMDGRDIGTCVLPDAQVKIYLTASVATRAKRRYDELTAKG
                     TQCNLEEIEKDIEDRDYRDMHRETSPLKQAKDAVLVDSSEMNIDEVVDAIYQIYARV"
     CDS             complement(1222..2451)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 58.4; E-value:
                     2.2e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg62_3"
                     /sec_met_domain="HI0933_like (E-value: 4.8e-137, bitscore:
                     446.5, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVIVVGGGPAGMFAAIAAAERGHEVVLLEKNEKLGKKLYITGK
                     GRCNITNAGDMDTLFANVMTNPKFLYSAFYDYDNQRVIDFFEENGLATKVERGNRVFPV
                     SDHSSDVIATLQRVLKRTGVMVQLHAEVRQILTGEGAVRGVKLADGSVLEAERVILATG
                     GFSYQTTGSTGDGYRFARELGHTVTQITPSLVPFYVKETCAARMQGLALKNVQVRIRDG
                     KKLLYDEFGEMLFTHFGVSGPLILSASAAIKPGRVEKELAMEIDLKPALTEEQLDARLL
                     REFEEAKNKQFKNAVVHLFPAKMIPVMLEAGAIDPEKKVNEITREERMGFVHLIKAFPL
                     TLCGVRDFNEAIITRGGVSVKEVNPSTMESKLVPGLYFCGELLDLDAMTGGFNLQIAWS
                     TGHLAGESIE"
     CDS             complement(2444..3376)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg62_4"
                     /sec_met_domain="SIS (E-value: 1.4e-24, bitscore: 76.1,
                     seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTNDLSNRINDAYSKLSKGQKRLATYITDNYDKAVFLTAAKLG
                     EVVGVSESTVVRFATHLGYKGYPEFQSALEELVRNKLNSIQRMEVTYGRISQSKILETV
                     LKSDADKIHSTLEKIDQNAFELAVDTILHAKHIYIIGIRSCAPLASFMAFYFTLMFPNV
                     HLIQTSSSSEIFEQMVRIGKEDVIIGISFPRYSMRTLKAMEFANNRSAKVITLTDSVHS
                     PMNLYSSCNLIADSDMASIVDSLVAPLSVINALIVALCMKKQNEVAKTLEMLEDIWDEY
                     QVYENDEINYIDDSIKMRYGKVGDAELYE"
     CDS             complement(3654..5330)
                     /locus_tag="ctg62_5"
                     /transl_table=11
                     /translation="MRKKEDRLKTAAFVLSAGVFFGVCPSIVLADEPGEWREENGSLYW
                     YENGIKQGTEGRGKEIYDPASDGWYWLDAIDGGKKAVGKDVYQESWAGSYADHEDGTGK
                     WVRYDTSGKMVKGWDVTERGAYYFDQTTGAMAKGETEIDGIPCIFDRETGIGWNLQWQE
                     REGARYWYEGGKRQGLEGRGKEIYDPASDAWYWLDSDVQGKMAVNKDVYQPYTIQGQDE
                     TGKWVRYDADGHMVKGWDRQNESTYYFDQTTGAMAKGVAKIDGVSYYFNETTGVCEGEY
                     TPSDSSEPTNVTTYTANDQVSEYTENELDASGNVVKSTTYSASGVKKTERTDAFDQYGN
                     QIRGTYVIYRGGEVYSTATDETVYEYNADGQPLSMTCYNDSQMFSRVLYTYDNGKTAKV
                     EYYVPLDGEEELSNYEQYFYENGRCVRKENYVLSYTDGAWNISLDTSDYYAYNSNGNLI
                     RETNKSARGNVNYYYTYDYDASGNLIAKGCYAKDDSQQWKEVWDYEGTLLVSDYYYSEE
                     ALEYYIIYVNRQRSGHLYQKIEKSYAGDGTYSGKRVYTYEG"
     CDS             complement(5533..6951)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_6"
                     /sec_met_domain="HMGL-like (E-value: 9.3e-46, bitscore:
                     146.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.2e-59, bitscore:
                     191.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVVKKPLKITETVLRDAHQSLIATRMTTEQMLPIVDKMDKVGY
                     NAVECWGGATFDACLRFLKEDPWDRLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSIANGIDIIRIFDCLNDVRNLQTAVTACNKEKGHAQVALSYTLGDAYTLDYWME
                     MAKKVEDMGADSLCIKDMAGLLVPTKATELIQALKSATNLPIELHTHYTSGVASMTYMK
                     AVEAGCDIIDTAMSPFSMGTSQPATEVMVEAFKGTEFDTGLDQNLLAEIADYFRPMREE
                     ALESGLMNPKVLGVNIKTLLYQVPGGMLSNLLSQLKEQGKEDKFEEVLAEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKVATKETKDVLLGKYGQTVKPFNPEIVDKVLGE
                     EKKNAITCRPADLLEPELDKIEAEMKQWKQQDEDVLSYALFPQVATEFFKYREAQQKKV
                     DASVADTKNGAYPV"
     CDS             complement(7017..8165)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_7"
                     /sec_met_domain="OAD_beta (E-value: 2.7e-157, bitscore:
                     512.8, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYFSETMGNLLHQTAFFNLTWGNFVMIIVACFFLYLAIAKGFEP
                     LLLVPIAFGMLLVNIYPDIFADPEQMSNGVGGLFHYFYVLDEWSILPSLIFLGVGAMTD
                     FGPLIANPISFLLGAAAQFGIFGAYFLAIMMGFNDKAAAAVSIIGGADGPTSIFLAGKL
                     GQSGLMGPIAVAAYSYMALVPIIQPPIMKLFTTKKERAIKMENLRPVSKLEKILFPIVV
                     TVVVCTILPTTAPLVGMLMLGNLFRESGVVRQLTDTASNALMYIVVILLGTSVGASTSA
                     EAFLNTTTLKIVALGLIAFMFGTAAGVLFGKLLCFLTKGKINPLIGSAGVSAVPMAARV
                     SQKVGAEEDPTNFLLMHAMGPNVAGVIGTAVAAGVFMAIFGI"
     CDS             complement(8181..8546)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 61.7; E-value:
                     1.5e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_8"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.8e-20, bitscore:
                     61.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGNVYDVTVEENGAVSAPAAAPRRAAAPAAAPAAKPA
                     AAAGAGSVKIEAGAAGKVFKLEKSVGDAVKKGDSIMVLEIMKMETPVVATQDGTVASIN
                     VSVGDMVEAGALLATLN"
     CDS             complement(8588..9340)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_9"
                     /sec_met_domain="OAD_gamma (E-value: 4.9e-26, bitscore:
                     81.0, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQNRKVKFMKKKLSLILCLCFMALGLAACGTDPTTVDYFGMTYD
                     ELQSSMEQEVSALVGLTDDNRTYIQSYGSDTAMKLVESWDEATSDVGAYQGLGEFNITK
                     AQKTLTVDQYVEYQNREVIVSYIYTYNYETEQPELTDATADKVYTLGEKMEKAALNTLM
                     GMGTVFVVLILISLIIYCFRFISVIQNKAAGKGKKNEAEAGAVVEQIGQREEQLTDDLE
                     LVAVISAAVAASTGASADSFVVRSIRRR"
     CDS             complement(9327..10820)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_10"
                     /sec_met_domain="CT_Vparvula (E-value: 3.5e-125, bitscore:
                     408.0, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPHPKWMWTTIYRWRAKRMNSSNDSLAMQRITRLVDENSFIEIG
                     SLVTARSTDFNLAATDTPSDGVITGHGLIDGNLVFIYSQDASVLNGTIGEMHAKKIAAV
                     YDMAMKMGAPVIGFIDCAGVRLQESVDALDGFGLIYAKEVAASGVVPQISAVFGSCGGG
                     LAVVPALSDFAFIEESKGKMFVNSPNAIDGNRIEKCDTSSAAFQADENGCIDATGTEDE
                     ILADIRELVGMLPLNNEGDVYTDECADDLNRACESMDAMKGDPRYLLSEISDSHTFFET
                     KAGYARDMVTGFIKLNGMTVGAVANCTTVYDEEGKESEKFDNVLSAKGCEKAAEFVSFC
                     DAFEIPVLTLTNVKGYKACKCSEKRLAKALAHLTSAFAGATCPKVNLITGEAYGTAYVA
                     MNSKSIGADFVYAWPDAKVGMMDADLAVKIMYADASADELAEKAKEYDALQGSVMTAAR
                     RGYVDLIVDPADTRKYLVDAFELLYTKCAYTPDKKHGTK"
     CDS             complement(10949..12301)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg62_11"
                     /sec_met_domain="Peptidase_S11 (E-value: 2.7e-51, bitscore:
                     163.9, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSPSVFLIILLIKARYAYCGSSFLHTVSVLQKMRDAYTSVKSFW
                     ENGMYRRFLSLLLSMSLLIFSPVRVRAQDVPAESELYAKSAVLMDADSGRILYEKNGHE
                     AMANASTTKILTCIVALENCDPASVVTVSKNAASQPKVHLGMHEGQQFYLRDLLYGLML
                     ESYNDCAVAIAEFAAGEVQGFAALMNAKAEELGCEDSYFITPNGLDAKDDAGFHHTTAA
                     DLAKIMKYCIKESLKSDEFLEITRTAQYSFSDAEGKCTYQCTNHNAFLQMMEGALSGKT
                     GFTGTAGYCYVGALQREDKTLIVALLACGWPNNKTYKWSDTRKLMNYGLEQFKKIDLLQ
                     IEPDEAELAPIEVRDGQGGKIGETVYLKLVVRNYAGEESILAPLSSEVTLRYEIADRLY
                     APVKSGDYIGKIRYMLGEETLAERCVVAGETIGKIDYPWCLGQVLRLLWIE"
     CDS             complement(12298..12396)
                     /locus_tag="ctg62_12"
                     /transl_table=11
                     /translation="SKRGRDTESDANIQPEEMLTFFSNEYSICIST"
ORIGIN
        1 tttcaactaa ttcttgaaat ttattgtaat taaatgtcgt ttgtgataca atacatacct
       61 ttttcccatg ggaagcatcg tatttttcgg cctcttcgcg ggttccgatc acgcgcgtat
      121 cctctgcatt cgaccagctt ttgatgcctt tcacctccgg gtggctggca ttcccgacga
      181 tcacaatgtg acagtcctcc ccactgtagc gctccaccag ccggtgaatc tttaacacaa
      241 acgggcaggt cgcgtccacg atggaaaagc cgagcgtctg tattttctcg cagacacctc
      301 tctccacgcc gtgtgcccgg atgattaccg tcccctgcgg cttccccgca agttcgtcca
      361 catcgtttac cacgacgacg cccttttcct ccagatcacg caccacttct tcattgtgga
      421 tgatcggtcc gaacgtgtag agcggttctt tttccaaaat ccgttcatat accatatcca
      481 cggcacgttt taccccgaag cagaagcccg cgctctttgc caagattaca ttcatattct
      541 ctataccctc gcataaatct gatagattgc gtccaccact tcgtcgatgt tcatctcgga
      601 gctgtccact aacaccgcat ccttggcctg ctttaacggc gacgtctccc ggtgcatatc
      661 gcggtaatcg cggtcttcaa tatctttctc gatctcttcc agattgcact gggttccctt
      721 ggcggtcagt tcatcatatc tgcgctttgc gcgcgttgca acgcttgccg tgagatatat
      781 ttttacctgc gcatccggaa gcacacaggt gccgatatcc cttccgtcca tgatgacgtc
      841 cgtctttgtc gcaagctgcc gctgcagttc cacaagcttt gtgcgcacaa ccggatagac
      901 actggtcgct gatgccatat tgccgacttc ctccgtccga atgacgccgt ttacattctc
      961 tccgtttaag agcacctgct gttcgccgtt ctcatacaca atcgtcacgt caaccttcgg
     1021 gcaggctgcc gcaatcgcct gctcatcatc tggtgcaatg ccgttctgta aaaaatagta
     1081 tgccatcgca cggtacattg ctcccgtatc cacatagaca aacgccagct ttttcgccag
     1141 ttttttcgca attgtgctct tcccggcgcc tgccggtccg tcaatcgcaa tattcatact
     1201 catctcttct tctctcctct tctattcgat actctcaccc gccagatgcc cggtcgacca
     1261 ggcaatctgc agattaaatc cgccggtcat cgcatccaga tccaatagtt ccccgcagaa
     1321 atacaatccc ggcacaagct ttgattccat cgtggaaggg ttcacttcct ttacgctgac
     1381 acccccgcgt gtgatgatcg cttcattgaa atctctgaca ccgcagagcg tcagcggaaa
     1441 cgccttgatc agatgcacaa atcccatccg ctcctctctc gtgatctcgt tgaccttctt
     1501 ctccggatca atcgctccgg cttctaacat caccggaatc atcttcgccg ggaacagatg
     1561 cacgacggcg tttttaaact gcttattctt tgcctcctcg aattcacgca gaagtctcgc
     1621 atccagctgt tcctccgtga gtgccggctt taagtcgatc tccatcgcca gttccttctc
     1681 cacgcggccc ggcttgattg ccgcactggc gcttaaaatc agcggtccgc ttaccccgaa
     1741 atgggtaaag agcatctcgc cgaattcgtc atacaacagc ttttttccgt cccggatgcg
     1801 cacctgcaca tttttcagcg ccagcccctg catcctcgcc gcgcaggtct ccttcacgta
     1861 gaacggaacc agtgacggcg taatctgtgt caccgtatgt ccgagttccc tcgcaaaacg
     1921 gtagccgtct ccagtcgaac cggtcgtctg ataagaaaat cctccggttg caagaatcac
     1981 gcgctctgct tcaagaacgc ttccgtcggc aagcttcacg ccgcgcaccg cgccttcccc
     2041 ggtgaggatc tgccgcactt ccgcatgaag ctgcaccata acacccgtgc gctttagtac
     2101 ccgctgcagc gtggcgatca catccgaaga atgatccgat accgggaata cacggttgcc
     2161 gcgctccacc ttcgtcgcca gaccattctc ctcaaaaaaa tcaatcactc tctgattgtc
     2221 ataatcgtaa aaagcgctgt ataaaaactt cgggttcgtc atcacattgg caaacagggt
     2281 gtccatatcc cccgcattcg tgatgttgca ccgccctttg ccggtgatgt agagcttttt
     2341 ccctagcttt tcatttttct cgagcaaaac gacctcatgt ccccgctccg ccgccgcaat
     2401 ggcagcaaac attcccgccg gcccgccgcc gactacgatc accttactca tacagttccg
     2461 catctcctac ttttccatac cgcatcttga tggaatcatc gatataattg atctcatcgt
     2521 tctcataaac ctggtattcg tcccagatat cctctaacat ctcaagcgtt ttcgccacct
     2581 cgttctgctt tttcatgcag agcgccacaa tcagcgcatt gatcaccgac agcggggcaa
     2641 ccaaggaatc cacaatggaa gccatatcgc tgtccgcaat cagattgcag gaagaataga
     2701 ggttcatcgg ggaatgtacg ctgtcggtga gtgtgattac cttcgcactc cggttatttg
     2761 caaattccat cgcctttaaa gtacgcatgg aataacgcgg aaaactgatt ccgatgatca
     2821 catcctcctt gccgatgcgc accatctgtt caaaaatctc gctcgaactg cttgtctgaa
     2881 tcagatgaac gttcggaaac atcagggtaa aataaaaagc catgaagctg gcaagcggcg
     2941 cacagctccg gattccgatg atatagatat gtttggcgtg caggatcgtg tcaaccgcga
     3001 gttcaaatgc attctgatca atcttttcca gtgtggaatg gatcttgtcc gcgtcggatt
     3061 tcagcaccgt ctccagaatc ttcgactggc tgatcctgcc gtaagtaacc tccatgcgct
     3121 gaatagaatt cagcttattg cgcaccagtt cctccagcgc actctggaat tccggatagc
     3181 ccttatatcc cagatgtgtc gcaaagcgta ccaccgtgga ctcgctcacg cccacaacct
     3241 cacccagctt tgcggcggtc agaaataccg ccttgtcata attgtccgta atgtaggttg
     3301 ccagacgttt ctgccctttg ctcagcttgc tgtaagcatc attgatgcgg ttactcaggt
     3361 catttgtatt gctcatgctt ctcctcactt ctgcggaatt gtgatccgcc caatgttttt
     3421 attatatcaa atacattgtg ttttgcaaga aattgtacat ggaactttcc tcacatgcag
     3481 cgcattttcc aacgctgcat atattaaacc aacagcattg ttatcatcgg aagatttttc
     3541 atcattcacc ggatgccgga taactttgca acgaagcctg ccggctgctc cagaaaacag
     3601 attaccggcg gtgtcatacg gtaagggaag gaaaccgggt tgtccgtttc cctctaacct
     3661 tcataagtgt agaccctttt accggaatac gttccatctc ccgcataaga tttttctatt
     3721 ttctgatata aatgaccgct gcgctgtctg tttacataga taatataata ttccagggct
     3781 tcttcactgt aataataatc gcttaccaga agcgttccct cataatccca gacttccttc
     3841 cactgctgac tgtcatcttt tgcataacag cccttggcaa tcagattgcc actcgcatca
     3901 taatcatatg tataatagta gttcacattc cctctggcgc tcttattggt ctcacggatc
     3961 agatttccat tactgttata tgcataataa tccgatgtat ccaagctaat attccacgca
     4021 ccatctgtat agctgagcac ataattttcc tttcgaacac atcttccgtt ttcgtaaaaa
     4081 tactgttcat aattacttaa ttcttcttcc ccatccagcg gaacataata ctctactttt
     4141 gcagtctttc cattgtcata tgtataaagt acccgcgaaa acatctgtga atcattataa
     4201 catgtcatgg ataatggctg accgtcggca ttatactcat acactgtctc atccgttgct
     4261 gtcgaataaa cttctcctcc ccgatatata acataagttc cccggatctg atttccgtac
     4321 tgatcaaatg catcggtacg ttctgttttt tttactcctg atgcactgta agttgtactt
     4381 tttaccacat tgcctgacgc gtccaactca ttttctgtat attcactgac ctgatcgttt
     4441 gccgtgtagg ttgtcacatt tgttggctca ctgctgtctg atggtgtata ctccccttca
     4501 caaacaccgg tcgtttcatt aaaataatag ctgacaccat caatcttcgc cacgcccttt
     4561 gccatcgctc cagttgtctg atcaaaataa taggtacttt cattttgtct gtcccagcct
     4621 tttaccatat gtccatctgc atcatagcgt acccattttc cagtctcatc ctgtccctga
     4681 attgtatagg gctgataaac atccttgttt accgccattt tcccctgcac atcgctgtcc
     4741 agccagtacc atgcatcact tgccggatca tagatttcct tccctctgcc ttcgagtccc
     4801 tgacgttttc ctccttcata ccagtatcgt gccccctctc tctcctgcca ttgcagattc
     4861 cagccaatgc ccgtctcccg gtcaaaaata catggtattc catctatctc cgtttctcct
     4921 tttgccatcg ctccggtcgt ctggtcaaaa tagtatgcac ctctctccgt cacatcccag
     4981 ccttttacca ttttcccact ggtatcatag cgcacccatt tcccggtgcc gtcctcatgg
     5041 tctgcataag atcctgccca tgattcctga tacacatcct ttccgaccgc ctttttcccc
     5101 ccatcaatgg catccagcca ataccagcca tcgctcgccg gatcataaat ctccttgccc
     5161 cttccttctg ttccctgctt tatgccattt tcataccaat agagactgcc attttcttcc
     5221 cgccattctc ccggctcatc tgccagcaca atcgacgggc atacaccaaa aaacacccct
     5281 gcgctcaaaa caaatgctgc tgttttcaac ctatcctctt tttttctcat gtcatcctct
     5341 tttttgttgt tttactgttt tgcattcgat actgcatctc aaatcatcct gcgattcata
     5401 ttcctatgat actgaaacac tctctttttt tcaataaaat gttactgcaa ataccctgca
     5461 ttcataattt tcccattttt aaaacaaaaa gcaggtgact gctcacccgc tttttgtttt
     5521 aactgttttt gattataccg gatatgctcc gttcttggta tctgcgacgc ttgcatcgac
     5581 cttcttctgc tgtgcctcac ggtacttgaa gaattcggtt gcaacctgcg ggaacagtgc
     5641 gtaggacagt acatcctcat cctgctgctt ccactgcttc atctcagcct cgatcttatc
     5701 cagctccggc tcaagcagat ctgccggacg gcaggtaatg gcgttcttct tctcctcgcc
     5761 aagtaccttg tctacgatct ccgggttgaa cggttttaca gtctgaccgt actttccaag
     5821 cagtacgtct ttggtctcct tggttgccac tttgtagcgc tctcccatca gtacgttgaa
     5881 cacagcctgt gtaccaacga tctgtgagga cggtgtaaca agtggcggct caccgaggtc
     5941 tttacgcaca cgcggaacct ctgcaagaac ctcctcgaac ttgtcttcct tgccctgctc
     6001 ttttaactga gacagaaggt tggataacat accacccggt acctgatata acagagtctt
     6061 gatgttaacg ccgagaacct tcgggttcat cagaccgctc tctaacgctt cctcacgcat
     6121 cggacggaag tagtcagcga tctcagctaa caggttctga tccagaccgg tatcgaactc
     6181 tgtgcccttg aatgcctcta ccataacctc ggttgccggc tggctggttc ccatggagaa
     6241 cggagacatt gctgtatcga taatgtcaca gcctgcctca accgccttca tgtatgtcat
     6301 ggaagcgaca ccggaagtat agtgtgtatg gagctcgatc ggaaggttgg ttgcagactt
     6361 taatgcctga atcagctcgg ttgccttcgt cggaaccaaa agacctgcca tatccttgat
     6421 acataaggaa tcagcaccca tatcctctac cttcttcgcc atctccatcc agtaatccag
     6481 agtgtaggca tcgccaagtg tataggataa tgcgacctgt gcatgtcctt tctctttgtt
     6541 acatgcggta acggctgtct gcaggttgcg gacatcgttt aagcagtcga aaatacgaat
     6601 gatatcaata ccgtttgcga tcgatttctg tacgaaatac tctaccacat catccgcata
     6661 cggacgatat cctaagatgt tctgtccacg aaacagcatc tgaagcttgg tgttcttaaa
     6721 tccgtctctt aacttgcgga gacgatccca cggatcttcc ttcaggaaac gaaggcatgc
     6781 atcgaaggta gcaccgcccc agcactcaac cgcattgtat ccgaccttat ccatcttgtc
     6841 tacgatcgga agcatctgct cggttgtcat tcttgtcgca atcagggact ggtgcgcatc
     6901 acgcagcacc gtctctgtta tttttaaagg ttttttaaca acttctgaca ttttttcctc
     6961 cttatcagcg gatactttga taccgctatc cgtctatgac ggcatttact ctttcactaa
     7021 attccgaaaa ttgccatgaa tacaccggct gctactgcag taccgataac gccggcaacg
     7081 ttcggtccca tcgcatgcat cagcaggaag ttcgtcggat cttcctccgc gccgactttc
     7141 tgggatacac gggctgccat aggaacggca gatacaccgg cagatccgat cagaggattg
     7201 atcttgccct ttgtgaggaa gcataacagc ttaccaaaca ggacaccggc tgctgtaccg
     7261 aacataaatg caatcagtcc aagtgcaacg atctttaatg tcgttgtatt taagaacgcc
     7321 tccgcactcg tagatgcacc tacggaagta ccgagcagga taactacgat gtacatcaat
     7381 gcgttggatg cggtatcggt cagctggcgg accacaccgc tctcgcggaa caggttaccg
     7441 agcatcagca taccaaccag cggcgctgtc gtcggaagaa tcgtacatac aaccaccgta
     7501 accacgatcg ggaagagaat cttctccagc ttggaaaccg gtcttaagtt ctccatcttg
     7561 atggcgcgct cttttttggt tgtaaacagc ttcataattg gcggctggat gatcggcaca
     7621 agcgccatat aggaatatgc cgccacagcg atcggtccca tcagtcccga ctgtcctaac
     7681 tttccggcaa ggaaaatgga ggtcggtcca tcggctccac cgatgatgga aacagcagct
     7741 gctgccttat cattaaagcc catcatgatt gcaaggaagt acgctccgaa aataccgaac
     7801 tgagctgcag ctccaagcag gaaactgatc gggtttgcaa tcagcggtcc gaaatctgtc
     7861 atagcaccga ctccaaggaa aatcagagac ggtaagattg accactcgtc taacacataa
     7921 aagtagtgga ataaaccacc tacaccattg ctcatctgct ccgggtctgc aaaaatatcc
     7981 ggatagatat ttacaagcag cataccgaat gcaatcggaa caagaagcaa tggctcaaac
     8041 cccttcgcga tagccagata caggaaaaag catgcgacaa tgatcatcac aaaatttccc
     8101 caggtaaggt taaagaaagc ggtctgatgc aggaggttcc ccattgtctc actaaaatag
     8161 ctcattgtct tcctcctaaa ttagtttaat gttgcaagta atgcgcccgc ttctaccata
     8221 tctccaacac ttacgttgat acttgctacc gtaccgtcct gcgttgcaac gaccggagtc
     8281 tccatcttca tgatctcaag aaccatgatg ctgtctccct tcttaacagc gtcgccgaca
     8341 gacttctcaa gtttgaatac ctttcctgct gcgcctgcct caatcttaac gctgcctgcg
     8401 cctgctgcag cagccggctt tgctgcaggt gctgccgccg gtgctgctgc acgtctcggt
     8461 gctgctgccg gtgcgctcac tgcgccgttc tcttctacgg ttacatcata tacattgccg
     8521 tttactgtaa ttgtatagct tttcattgaa atatcctcct aatatgattt cttttcattt
     8581 atacgaatta gcgtctgcgg atcgatctca caacgaaaga atccgcggat gcaccggtgc
     8641 ttgccgcaac cgctgcggaa ataactgcca caagttcaag atcatcggta agctgctctt
     8701 cacgctgtcc gatctgctct accacagcgc ctgcctctgc ctcgttcttc ttgcccttgc
     8761 cggccgcctt gttctgtatt acagagataa agcggaaaca gtaaataata aggctgatca
     8821 ggatcagaac cacgaatacg gttcccattc ccatcagggt atttaacgca gccttctcca
     8881 tcttctcacc cagcgtatat accttgtccg cggttgcatc ggtaagctcc ggctgctcgg
     8941 tctcgtaatt gtatgtatag atgtaagaaa cgatgacttc acgattctga tactctacat
     9001 actgatctac tgttaaggtt ttctgtgcct ttgtgatatt gaattctcca agtccctgat
     9061 atgcgccgac atcacttgtc gcctcatccc agctctcgac aagtttcatt gccgtatcgc
     9121 tgccgtagga ctggatatag gttctgttgt cgtccgtaag accaaccagc gcggaaactt
     9181 cctgttccat gctgctctgc agttcatcgt aagtcattcc gaaatagtca accgttgtcg
     9241 gatctgttcc gcatgctgca agtcccagag ccataaagca aagacaaagt ataagagata
     9301 attttttctt cataaacttc acctttctat tttgttccat gtttcttgtc cggtgtatat
     9361 gcacactttg tgtataacag ttcaaacgca tctaccagat actttctcgt atctgccgga
     9421 tcaacgatca gatccacata gcctcttctg gctgctgtca taacgctgcc ctgcagtgca
     9481 tcatattcct ttgccttctc tgcaagctca tccgcagatg catccgcgta catgatcttt
     9541 actgcaagat ccgcatccat catgccgacc tttgcgtccg gccatgcata tacgaaatcc
     9601 gcaccgatag acttggaatt catagcaaca taagcggtac cgtatgcctc tcccgtgatc
     9661 aggttcacct tcggacatgt agctcccgca aatgcggagg tcagatgagc aagtgccttt
     9721 gcaagacgct tttcagagca cttgcatgcc ttgtagccct tgacatttgt cagagtcagt
     9781 accgggatct cgaatgcgtc gcagaaagat acgaactctg ctgccttctc acatcccttt
     9841 gcggaaagaa cattgtcaaa tttctcgctc tctttgccct cttcgtcgta taccgttgtg
     9901 cagtttgcaa ctgcgccgac cgtcataccg tttaacttga taaatccggt caccatgtct
     9961 ctggcatagc ctgcctttgt ctcgaagaat gtatggctgt ccgaaatctc actgagaaga
    10021 tatctcggat cacccttcat ggcatccatg ctctcgcatg cacggttcag gtcatccgca
    10081 cactcgtctg tgtagacatc tccctcgttg ttgagcggaa gcatgccgac cagctcacgg
    10141 atgtctgcaa ggatctcatc ctctgttccc gtcgcgtcga tgcagccgtt ctcatctgcc
    10201 tggaatgccg cagatgatgt gtcgcacttc tcgatgcggt ttccgtcaat tgcgttcgga
    10261 gaattcacaa acatctttcc tttggattct tcgataaaag caaaatcaga aagtgccggt
    10321 accactgcca gtccaccgcc gcagctgccg aatacggctg aaatctgcgg aaccacgccg
    10381 gatgctgcaa cttcttttgc atagatcagt ccgaagccgt caagcgcatc tacagactcc
    10441 tgtaaacgga ctcccgcgca atcgataaaa ccgatcaccg gtgctcccat cttcatcgcc
    10501 atgtcataca ctgcagcgat cttcttcgca tgcatctcgc cgattgttcc gtttaaaaca
    10561 gaagcgtcct ggctgtaaat gaacaccaga ttgccgtcaa tcaggccgtg tcctgtgatg
    10621 actccgtcgg aaggagtatc cgttgctgca agattaaaat ctgtgcttct tgcggttacg
    10681 agagaaccga tctcaatgaa actgttctcg tcgactaacc tggtgatgcg ctgcatagcc
    10741 aggctatcat tgctactatt cattcttttt gccctccatc tataaattgt tgtccacatc
    10801 catttgggat gcggcttcat agtgaatgat gtaaatccat gcgtctttgt ataaaaattc
    10861 aacaaattac gctatgttaa attataattg cttttctgca atatttcaag taaattgtta
    10921 attttttgac gctttttgtt tgtgtttttt attcgatcca gagaagccga agcacctgcc
    10981 ccagacacca cggataatcg atctttccga ttgtctcccc ggctaccaca catcgctccg
    11041 caagcgtctc ctcccccagc atataacgaa tcttcccgat gtaatctccg ctcttcaccg
    11101 gtgcatacag ccggtctgca atctcatacc taagcgtaac ctcactgctt agcggcgcca
    11161 ggatactctc ctcccctgca tagttcctga caaccagttt taaatacacc gtttcgccga
    11221 tttttccgcc ctgtccgtcc cgcacctcta tgggcgcaag ctccgcttcg tccggctcaa
    11281 tctgcagcag gtcgatcttt ttgaactgct ccaatccgta attcatgagt tttctggtgt
    11341 cggaccactt ataggtcttg ttgttcggcc atccacaggc gagcagcgcc acgatcagcg
    11401 ttttgtcctc ccgctgcagc gctccgacat agcagtatcc ggcggttccg gtaaatcccg
    11461 tttttccgga aagcgcccct tccatcatct gcaaaaatgc attgtggttc gtgcactggt
    11521 acgtgcattt cccctctgca tcagaaaaag aatactgcgc cgtccgtgta atctcgagaa
    11581 attcgtcgct ttttaacgat tccttaatac aatatttcat aatcttagca aggtctgccg
    11641 ccgtcgtgtg atgaaacccg gcatcatcct tcgcatccag tccgttcggt gtaataaagt
    11701 agctgtcctc acagccgagt tcctctgcct tcgcattcat cagcgcggca aatccctgca
    11761 cctcccccgc cgcaaattcc gcgatggcca ccgcacagtc attgtaggat tccagcatca
    11821 gaccatataa aagatccctc agataaaact gttgtccctc gtgcatcccc agatgtacct
    11881 tcggctggga cgccgcattt tttgacaccg taaccacgct cgccggatca cagttttcca
    11941 gtgccacgat acaggttaaa atctttgtcg tactcgcatt cgccatcgct tcatgcccgt
    12001 ttttctcata gagaattctt ccggaatccg catccatcaa aacggcagat tttgcgtaca
    12061 gttccgactc tgccggcaca tcctgcgccc ggacacgcac aggcgaaaaa ataagcaagc
    12121 tcatacttaa caatagagaa agaaagcgtc gatacatgcc attctcccaa aatgacttca
    12181 ctgatgtata tgcgtccctc attttttgca gaacagaaac ggtatgtaaa aaggaactgc
    12241 cgcaataagc atatcgtgct ttgataagta atattattag aaacacactt ggggatttca
    12301 tgtggaaatg cagatggaat attcgttgga gaaaaatgtg agcatttctt ccggctgaat
    12361 gtttgcatcg gattccgtgt ctcttccacg tttggaca
//
