LOCUS       c00111_gnlPro..        11411 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JNBILIEM_111.
ACCESSION   c00111_gnlPro..
VERSION     c00111_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 01:51:10
            Original ID  :: gnl|Prokka|JNBILIEM_111
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11411
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11411
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4586:9817]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4587..9817
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..11411
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11411
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(3..206)
                     /locus_tag="ctg111_1"
                     /transl_table=11
                     /translation="MSEMSFEQMLEESFKTIRNGEVVEGTVIDVKPDEIVLNIGYKADG
                     IITRNEYTNEANVDLTTLVSVGD"
     CDS             complement(187..1038)
                     /locus_tag="ctg111_2"
                     /transl_table=11
                     /translation="MNVILAKSAGFCFGVKRAVDTVYERILEKEPLYTFGPIIHNEEVV
                     RDLEEKGVVVVNDVDELAGKPQGTVIIRAHGVERGVCEKIQTLGFSIVDATCPFVLKIH
                     RLVERYSGEDCHIVIVGNASHPEVKGIKSWSNAEDTRVIGTREEAEKYDASHGKKVCIV
                     SQTTFNYNKFQELVEIIKEKGYDIIVLNTICNATEERQTEARVIAEQVDAMIVIGGRNS
                     SNTQKLFEICKNECKNTYYIQTVKDLDLAEVRSVDNVGITAGASTPNNIIEEVQKNVRN
                     EL"
     CDS             complement(1044..1706)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_3"
                     /sec_met_domain="Cytidylate_kin (E-value: 5.1e-81,
                     bitscore: 261.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMNIAIDGPAGAGKSTIAKKLAKKLAFVYVDTGAMYRAMAYYFL
                     QNGIAPDDEQAIAAACPKVDVTIVYENGEQQVLLNGENVNGVIRTEEVGNMASATSVYP
                     VVRTKLVELQRQLATKTDVIMDGRDIGTCVLPDAQVKIYLTASVATRAKRRYDELTAKG
                     TQCNLEEIEKDIEDRDYRDMHRETSPLKQAKDAVLVDSSEMNIDEVVDAIYQIYARV"
     CDS             complement(1725..2954)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 58.4; E-value:
                     2.2e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_4"
                     /sec_met_domain="HI0933_like (E-value: 4.8e-137, bitscore:
                     446.5, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVIVVGGGPAGMFAAIAAAERGHEVVLLEKNEKLGKKLYITGK
                     GRCNITNAGDMDTLFANVMTNPKFLYSAFYDYDNQRVIDFFEENGLATKVERGNRVFPV
                     SDHSSDVIATLQRVLKRTGVMVQLHAEVRQILTGEGAVRGVKLADGSVLEAERVILATG
                     GFSYQTTGSTGDGYRFARELGHTVTQITPSLVPFYVKETCAARMQGLALKNVQVRIRDG
                     KKLLYDEFGEMLFTHFGVSGPLILSASAAIKPGRVEKELAMEIDLKPALTEEQLDARLL
                     REFEEAKNKQFKNAVVHLFPAKMIPVMLEAGAIDPEKKVNEITREERMGFVHLIKAFPL
                     TLCGVRDFNEAIITRGGVSVKEVNPSTMESKLVPGLYFCGELLDLDAMTGGFNLQIAWS
                     TGHLAGESIE"
     CDS             complement(2947..3879)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_5"
                     /sec_met_domain="SIS (E-value: 1.4e-24, bitscore: 76.1,
                     seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTNDLSNRINDAYSKLSKGQKRLATYITDNYDKAVFLTAAKLG
                     EVVGVSESTVVRFATHLGYKGYPEFQSALEELVRNKLNSIQRMEVTYGRISQSKILETV
                     LKSDADKIHSTLEKIDQNAFELAVDTILHAKHIYIIGIRSCAPLASFMAFYFTLMFPNV
                     HLIQTSSSSEIFEQMVRIGKEDVIIGISFPRYSMRTLKAMEFANNRSAKVITLTDSVHS
                     PMNLYSSCNLIADSDMASIVDSLVAPLSVINALIVALCMKKQNEVAKTLEMLEDIWDEY
                     QVYENDEINYIDDSIKMRYGKVGDAELYE"
     CDS             4041..4523
                     /locus_tag="ctg111_6"
                     /transl_table=11
                     /translation="MRDITPATNFIHTLMQSPPDASAWIAGGNNFPSISGLARFYATKY
                     EGTLVEVEVFGLPNVATPGSSNFYGMHIHENGVCVSPFTSAGAHYSRTPAEHPNHSGDM
                     PPLLGNQGYAWMAFYDKRFTIPEIIGKSLIIHRMPDNFTTQPAGDSGERIACGVIK"
     CDS             complement(4587..6005)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_7"
                     /sec_met_domain="HMGL-like (E-value: 9.3e-46, bitscore:
                     146.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.2e-59, bitscore:
                     191.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVVKKPLKITETVLRDAHQSLIATRMTTEQMLPIVDKMDKVGY
                     NAVECWGGATFDACLRFLKEDPWDRLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSIANGIDIIRIFDCLNDVRNLQTAVTACNKEKGHAQVALSYTLGDAYTLDYWME
                     MAKKVEDMGADSLCIKDMAGLLVPTKATELIQALKSATNLPIELHTHYTSGVASMTYMK
                     AVEAGCDIIDTAMSPFSMGTSQPATEVMVEAFKGTEFDTGLDQNLLAEIADYFRPMREE
                     ALESGLMNPKVLGVNIKTLLYQVPGGMLSNLLSQLKEQGKEDKFEEVLAEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKVATKETKDVLLGKYGQTVKPFNPEIVDKVLGE
                     EKKNAITCRPADLLEPELDKIEAEMKQWKQQDEDVLSYALFPQVATEFFKYREAQQKKV
                     DASVADTKNGAYPV"
     CDS             complement(6071..7219)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_8"
                     /sec_met_domain="OAD_beta (E-value: 6.2e-157, bitscore:
                     511.6, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYFSETMGNLLHQTAFFNLTWGNFVMIIVACFFLYLAIAKGFEP
                     LLLVPITFGMLLVNIYPDIFADPEQMSNGVGGLFHYFYVLDEWSILPSLIFLGVGAMTD
                     FGPLIANPISFLLGAAAQFGIFGAYFLAIMMGFNDKAAAAVSIIGGADGPTSIFLAGKL
                     GQSGLMGPIAVAAYSYMALVPIIQPPIMKLFTTKKERAIKMENLRPVSKLEKILFPIVV
                     TVVVCTILPTTAPLVGMLMLGNLFRESGVVRQLTDTASNALMYIVVILLGTSVGASTSA
                     EAFLNTTTLKIVALGLIAFMFGTAAGVLFGKLLCFLTKGKINPLIGSAGVSAVPMAARV
                     SQKVGAEEDPTNFLLMHAMGPNVAGVIGTAVAAGVFMAIFGI"
     CDS             complement(7235..7600)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 61.7; E-value:
                     1.5e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_9"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.8e-20, bitscore:
                     61.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGNVYDVTVEENGAVSAPAAAPRRAAAPAAAPAAKPA
                     AAAGTGSVKIEAGAAGKVFKLEKSVGDAVKKGDSIMVLEIMKMETPVVATQDGTVASIN
                     VSVGDMVEAGALLATLN"
     CDS             complement(7642..8394)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_10"
                     /sec_met_domain="OAD_gamma (E-value: 1e-25, bitscore: 80.0,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQNRKVKFMKKKLSLILCLCFMALGLAACGTDPTTVDYFGMTYD
                     ELQSSMEQEVSALVGLTDDNRTYIQSYGSDTAMKLVESWDEATSDVGAYQGLGEFNITK
                     AQKTLTVDQYVEYQNREVIVSYIYTYNYETEQPELTDASADKVYTLGEKMEKAALNTLM
                     GMGTVFVVLILISLIIYCFRFISVIQNKVAGKGKKNEAEAGAVVEQIGQREEQLTDDLE
                     LVAVISAAVAASTGASADSFVVRSIRRR"
     CDS             complement(8381..9817)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_11"
                     /sec_met_domain="CT_Vparvula (E-value: 3e-125, bitscore:
                     408.3, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSSNDSLAMQRITRLVDENSFIEIGSLVTARSTDFNLAATDTPS
                     DGVITGHGLIDGNLVFIYSQDASVLNGTIGEMHAKKIAAVYDMAMKMGAPVIGFIDCAG
                     VRLQESVDALDGFGLIYAKEVAASGVVPQISAVFGSCGGGLAVVPALSDFAFIEESKGK
                     MFVNSPNAIDGNRIEKCDTSSAAFQADENGCIDATGTEDEILADIRELVGMLPLNNEGD
                     VYTDECADDLNRACESMDAMKGDPRYLLSEISDSHTFFETKAGYARDMVTGFIKLNGMT
                     VGAVANCTTVYDEEGKESEKFDNVLSAKGCEKAAEFVSFCDAFEIPVLTLTNVKGYKAC
                     KCSEKRLAKALAHLTSAFAGATCPKVNLITGEAYGTAYVAMNSKSIGADFVYAWPDAKV
                     GMMDADLAVKIMYADASADELAEKAKEYDALQGSVMTAARRGYVDLIVDPADTRKYLVD
                     AFELLYTKCAYTPDKKHGTK"
     CDS             complement(10003..11211)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_12"
                     /sec_met_domain="Peptidase_S11 (E-value: 2e-51, bitscore:
                     164.4, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRRFLSLLLSMSLLIFSPVRVRAQDVPAESELYAKSAVLMDADS
                     GRILYEKNGHEAMANASTTKILTCIVALENCDPASVVTVSKNAASQPKVHLGMHEGQQF
                     YLRDLLYGLMLESYNDCAVAIAEFAAGEVQGFAALMNAKAEELGCEDSYFITPNGLDAK
                     DDAGFHHTTAADLAKIMKYCIKESLKSDEFLEITRTAQYSFSDAEGKCTYQCTNHNAFL
                     QMMEGALSGKTGFTGTAGYCYVGALQREDKTLIVALLACGWPNNKTYKWSDTRKLMNYG
                     LEQFKKINLLQIEPDEAELAPIEVRDGQGGQIGETVYLKPVVRNYAGEESILAPLSSEV
                     TLKYEIADQLYAPVKSGDYIGKICYMLGEETLAERCVVAGETIGKIDYPWCLGQVLRLL
                     WIE"
ORIGIN
        1 gtgtcgccga cggataccaa tgtggtaagg tctacgtttg cttcgtttgt gtattcatta
       61 cgagtaatga ttccgtctgc cttgtagccg atattcagaa cgatctcatc aggtttcaca
      121 tcgataacgg taccctcaac tacctctcca tttcttattg ttttaaatga ttcttccagc
      181 atttgttcaa agctcatttc tgacattctt ttgaacctcc tcaataatat tgtttggggt
      241 agaagcccct gcggtaatac ctacgttatc gacagacctg acttcggcaa ggtcaagatc
      301 ctttacagtt tgtatatagt aagtattttt gcattcgttt ttacatattt caaatagctt
      361 ctgcgtgttg gaactgttcc tgccaccgat cacaatcatg gcatccacct gctccgcgat
      421 tacccgggct tccgtctgac gttcctccgt agcattgcag attgtattta aaacaattat
      481 atcataacct ttttctttta taatttcaac taattcttga aatttattgt aattaaatgt
      541 cgtttgtgat acaatacata cctttttccc atgggaagca tcgtattttt cggcctcttc
      601 gcgggttccg atcacgcgcg tatcctctgc attcgaccag cttttgatgc ctttcacctc
      661 cgggtggctg gcattcccga cgatcacaat gtgacagtcc tccccactgt agcgctccac
      721 cagccggtga atctttaaca caaacgggca ggtcgcgtcc acgatggaaa agccgagcgt
      781 ctgtattttc tcgcagacac ctctctccac gccgtgtgcc cggatgatta ccgtcccctg
      841 cggcttcccc gcaagttcgt ccacatcgtt taccacgacg acgccctttt cctccagatc
      901 acgcaccact tcttcattgt ggatgatcgg tccgaacgtg tagagcggtt ctttttccaa
      961 aatccgttca tataccgtat ccacggcacg ttttaccccg aagcagaagc ccgcgctctt
     1021 tgccaagatt acattcatat tctctatacc ctcgcataaa tctgatagat tgcgtccacc
     1081 acttcgtcga tgttcatctc ggagctgtcc actaacaccg catccttggc ctgctttaac
     1141 ggcgacgtct cccggtgcat atcgcggtaa tcgcggtctt caatatcttt ctcgatctct
     1201 tccagattgc actgggttcc cttggcggtc agttcatcat atctgcgctt tgcgcgcgtt
     1261 gcaacgcttg ccgtgagata tatttttacc tgcgcatccg gaagcacaca ggtgccgata
     1321 tcccttccgt ccatgatgac gtccgtcttt gtcgcaagct gccgctgcag ttccacaagc
     1381 tttgtgcgca caaccggata gacactggtc gctgatgcca tattgccgac ttcctccgtc
     1441 cgaatgacgc cgtttacatt ctctccgttt aagagcacct gctgttcgcc gttctcatac
     1501 acaatcgtca cgtcaacctt cgggcaggct gccgcaatcg cctgctcatc atctggtgca
     1561 atgccgttct gtaaaaaata gtatgccatc gcacggtaca ttgctcccgt atccacatag
     1621 acaaacgcca gctttttcgc cagttttttc gcaattgtgc tcttcccggc gcctgccggt
     1681 ccgtcaatcg caatattcat actcatctct tcttctctcc tcttctattc gatactctca
     1741 cccgccagat gcccggtcga ccaggcaatc tgcagattaa atccgccggt catcgcatcc
     1801 agatccaata gttccccgca gaaatacaat cccggcacaa gctttgattc catcgtggaa
     1861 gggttcactt cctttacgct gacacccccg cgtgtgatga tcgcttcatt gaaatctctg
     1921 acaccgcaga gcgtcagcgg aaacgccttg atcagatgca caaatcccat ccgctcctct
     1981 ctcgtgatct cgttgacctt cttctccgga tcaatcgctc cggcttctaa catcaccgga
     2041 atcatcttcg ccgggaacag atgcacgacg gcgtttttaa actgcttatt ctttgcctcc
     2101 tcgaattcac gcagaagtct cgcatccagc tgttcctccg tgagtgccgg ctttaagtcg
     2161 atctccatcg ccagttcctt ctccacgcgg cccggcttga ttgccgcact ggcgcttaaa
     2221 atcagcggtc cgcttacccc gaaatgggta aagagcatct cgccgaattc gtcatacaac
     2281 agcttttttc cgtcccggat gcgcacctgc acatttttca gcgccagccc ctgcatcctc
     2341 gccgcgcagg tctccttcac gtagaacgga accagtgacg gcgtaatctg tgtcaccgta
     2401 tgtccgagtt ccctcgcaaa acggtagccg tctccggtcg aaccggtcgt ctgataagaa
     2461 aatcctccgg ttgcaagaat cacgcgctct gcttcaagaa cgcttccgtc ggcaagcttc
     2521 acgccgcgca ccgcgccttc cccggtgagg atctgccgca cttccgcatg aagctgcacc
     2581 ataacacccg tgcgctttag tacccgctgt agcgtggcga tcacatccga agaatgatcc
     2641 gataccggga atacacggtt gccgcgctct accttcgtcg ccagaccatt ctcctcaaaa
     2701 aaatcaatca ctctctgatt gtcataatcg taaaaagcgc tgtacaaaaa ctttgggttc
     2761 gtcatcacat tggcaaacag ggtgtccata tcccccgcat tcgtgatgtt gcaccgccct
     2821 ttgccggtga tgtagagctt tttcccaagc ttttcatttt tctcgagcaa aacgacctca
     2881 tgtccccgct ccgccgccgc aatggcagca aacattcccg ccggcccgcc gccgactacg
     2941 atcaccttac tcatacagtt ccgcatctcc tacttttcca taccgcatct tgatggaatc
     3001 atcgatataa ttgatctcat cgttctcgta aacctggtat tcgtcccaga tatcctctaa
     3061 catctcaagc gttttcgcca cctcgttctg ctttttcatg cagagcgcca caatcagcgc
     3121 attgatcacc gacagcgggg caaccaggga atccacaatg gaagccatat cgctgtccgc
     3181 aatcagattg caggaagaat agaggttcat cggggaatgt acgctgtcgg tgagtgtgat
     3241 taccttcgca ctccggttat tcgcaaattc catcgccttt aaagtacgca tggaataacg
     3301 cggaaaactg attccgatga tcacatcctc cttgccgatg cgcaccatct gttcaaaaat
     3361 ctcgctcgaa ctgcttgtct gaatcagatg aacgttcgga aacatcaggg taaaataaaa
     3421 agccatgaag ctggcaagcg gcgcacagct ccggattccg atgatataga tatgtttggc
     3481 gtgcaggatc gtgtcaaccg cgagttcaaa tgcgttctga tcaatctttt ccagtgtgga
     3541 atgaatcttg tccgcgtcgg atttcagcac cgtctcaaga atcttcgact ggctgatcct
     3601 gccgtaagta acctccatgc gctgaatgga gttcagctta ttgcgcacca gttcctccag
     3661 cgcactctgg aattccggat agcccttata tcccagatgc gttgcaaagc gcaccaccgt
     3721 ggactcgctc acacctacaa cctcgcccag ctttgcagcg gtcagaaata ccgccttgtc
     3781 ataattgtcc gtaatgtagg ttgccagccg tttctgtccc ttgctcagct tactgtaagc
     3841 atcattgatg cggttactca ggtcatttgt attgctcatg cttctcctca cttctgcgga
     3901 attgtgatcc gctcaatgtt tttattatat caaatacatg gtgttttgca agaaattatg
     3961 catggaactt tcctcacatg cagcgcattt ttccgccgct gcatataata aaccaatgac
     4021 actcttccat tgaggcagct atgcgcgata tcacaccagc aaccaatttt attcatacac
     4081 tgatgcagtc tccgccggat gcatccgcct ggattgccgg cggcaacaat tttccttcca
     4141 tctccgggct tgcccggttc tatgccacaa aatacgaagg aactctcgtg gaggttgaag
     4201 tcttcggtct tccgaacgtc gcgactcccg gctccagtaa tttttacggc atgcacatcc
     4261 acgaaaacgg cgtgtgcgtc tccccgttta ccagtgccgg tgcccattac agccgtacgc
     4321 cggccgaaca cccgaatcac agcggcgaca tgcctccgct tctgggcaac cagggttatg
     4381 cctggatggc attttatgac aagcgtttta cgattccgga aattatcgga aaatccctca
     4441 tcattcaccg gatgccggat aactttacaa cgcagcccgc gggcgactcc ggcgaacgga
     4501 ttgcctgcgg tgtgataaaa tagcaaaaaa ggcagcaaaa aaagcaggtg actggtcacc
     4561 cgctttttgt tataactgtt ttttgattat accggatatg ctccgttctt agtatctgcg
     4621 acgcttgcat cgaccttctt ctgctgtgcc tcacggtact tgaagaattc ggttgcaacc
     4681 tgcgggaaca gtgcgtagga cagtacatcc tcatcctgct gcttccactg cttcatctca
     4741 gcctcgatct tatccagctc cggctcaagc agatctgccg gacggcaggt aatggcgttc
     4801 ttcttctcct cgccaagtac cttgtctacg atctccgggt tgaacggttt tacagtctga
     4861 ccgtactttc caagcagtac gtctttggtc tccttggttg ccactttgta gcgctctccc
     4921 atcagtacgt tgaacacagc ctgtgtacca acgatctgtg aggacggtgt aacaagtggc
     4981 ggctcaccga ggtctttacg cacacgcgga acctctgcaa gaacctcctc gaacttgtct
     5041 tccttgccct gctcttttaa ctgagacaga aggttggata acataccacc cggtacctga
     5101 tataacagag tcttgatgtt aacgccgaga accttcgggt tcatcagacc gctctctaac
     5161 gcttcctcac gcatcggacg gaagtagtca gcgatctcag ctaacaggtt ctgatccaga
     5221 ccggtatcga actctgtgcc cttgaatgcc tctaccataa cctcggttgc cggctggctg
     5281 gttcccatgg agaacggaga cattgctgta tcgataatgt cacagcctgc ctcaaccgcc
     5341 ttcatgtatg tcatggaagc gacaccagaa gtatagtgtg tatggagctc gatcggaagg
     5401 ttggttgcag actttaatgc ctgaatcagc tcggttgcct tcgtcggaac caaaagacct
     5461 gccatatcct tgatacataa ggaatcagca cccatatcct ctaccttctt cgccatctcc
     5521 atccagtaat ccagagtgta ggcatcgcca agtgtatagg ataatgcgac ctgtgcatgt
     5581 cctttctctt tgttacatgc ggtaacggct gtctgcaggt tgcggacatc gtttaagcag
     5641 tcgaaaatac gaatgatatc aataccgttt gcgatcgatt tctgtacgaa atactctacc
     5701 acatcatccg catacggacg atatcctaag atgttctgtc cacgaaacag catctgaagc
     5761 ttggtgttct taaatccatc tcttaacttg cggagacgat cccacggatc ttccttcagg
     5821 aaacgaaggc atgcatcgaa ggtagcaccg ccccagcact caaccgcatt gtatccgacc
     5881 ttatccatct tgtctacgat cggaagcatc tgctcggttg tcattcttgt cgcaatcagg
     5941 gactggtgcg catcacgcag caccgtctct gttattttta aaggtttttt aacaacttct
     6001 gacatttttt cctccttatc agcggatact ttgataccgc tatccgtcta tgacggcatt
     6061 tgctctttca ctaaattccg aaaattgcca tgaatacacc ggctgctact gcagtaccga
     6121 taacgccggc aacgttcggt cccatcgcat gcatcagcag gaagttcgtc ggatcttcct
     6181 ccgcgccgac tttctgggat acacgggctg ccataggaac ggcagataca ccggcagatc
     6241 cgatcagagg attgatcttg ccctttgtga ggaagcataa cagcttacca aacaggacac
     6301 cggctgctgt accgaacata aatgcaatca gtccaagtgc aacgatcttt aatgtcgttg
     6361 tatttaagaa cgcctccgca ctcgtagatg cacctacgga agtaccgagc aggataacta
     6421 cgatgtacat caatgcgttg gatgcggtat cggtcagctg gcggaccaca ccgctctcgc
     6481 ggaacaggtt accaagcatc agcataccaa ccagcggcgc tgtcgtcgga agaatcgtac
     6541 atacaaccac cgtaaccacg atcgggaaga gaatcttctc cagcttggaa accggtctta
     6601 agttctccat cttgatggcg cgctcttttt tggttgtaaa cagcttcata attggcggct
     6661 ggatgatcgg cacaagcgcc atataggaat atgccgccac agcgatcggt cccatcagtc
     6721 ccgactgtcc taactttccg gcaaggaaaa tggaggtcgg tccatcggct ccaccgatga
     6781 tggaaacagc agcagctgcc ttatcattaa agcccatcat gattgcaagg aagtacgctc
     6841 cgaaaatacc gaactgagct gcagctccaa gcaggaaact gatcgggttt gcaatcagcg
     6901 gtccgaaatc tgtcatagca ccgactccaa ggaaaatcag agacggtaag attgaccact
     6961 cgtctaacac ataaaagtag tggaataaac cacctacacc attgctcatc tgctccgggt
     7021 ctgcaaaaat atccggatag atatttacaa gcagcatacc gaatgtaatc ggaacaagaa
     7081 gcaatggctc aaaccccttc gcgatagcca gatacaggaa aaagcatgcg acaatgatca
     7141 tcacaaaatt tccccaggta aggttaaaga aagcggtctg atgcaggagg ttccccattg
     7201 tctcactaaa atagctcatt gtcttcctcc taaattagtt taatgttgca agtaatgcgc
     7261 ccgcttctac catatctcca acacttacgt tgatacttgc taccgtaccg tcctgcgttg
     7321 caacgaccgg agtctccatc ttcatgatct caagaaccat gatgctgtct cccttcttaa
     7381 cggcatcacc gacagacttc tcaagtttga atacctttcc tgctgcgcct gcctcaatct
     7441 taacgctgcc tgtgcctgct gcagcagccg gctttgccgc aggtgctgcc gccggtgctg
     7501 ctgcacgtct cggtgctgct gccggtgcgc tcactgcgcc gttctcttct acggttacat
     7561 catatacatt gccgtttact gtaattgtat agcttttcat tgaaatatcc tcctaatatg
     7621 atttcttttc atttatacga attagcgtct gcggatcgat ctcacaacga aagaatccgc
     7681 ggatgcaccg gtgcttgccg caaccgctgc ggaaataact gccacaagtt caagatcatc
     7741 ggtaagctgc tcttcacgct gtccgatctg ctctaccaca gcgcctgcct ctgcctcgtt
     7801 cttcttgccc ttgccggcca ccttgttctg tattacagag ataaagcgga aacagtaaat
     7861 aataaggctg atcaggatca gaaccacgaa tacggttccc attcccatca gggtatttaa
     7921 cgcagccttc tccatcttct cacccagcgt atataccttg tccgcggatg catcagtaag
     7981 ctccggctgc tcggtctcgt aattgtatgt atagatgtaa gaaacgatga cttcacgatt
     8041 ctgatactct acatactgat ctactgttaa ggttttctgt gcctttgtga tattgaattc
     8101 tccaagtccc tgatatgcgc cgacatcact tgtcgcctca tcccaactct cgacaagttt
     8161 cattgccgta tcgctgccgt aggactggat ataggttctg ttgtcgtccg taagaccaac
     8221 cagcgcggaa acttcctgtt ccatgctgct ctgcagttca tcgtaagtca ttccgaaata
     8281 gtcaaccgtt gtcggatctg ttccgcatgc tgcaagtccc agagccataa agcaaagaca
     8341 aagtataaga gataattttt tcttcataaa cttcaccttt ctattttgtt ccatgtttct
     8401 tgtccggtgt atatgcacac tttgtgtata acagttcaaa cgcatctacc agatactttc
     8461 tcgtatctgc cggatcaacg atcagatcca catagcctct tctggctgct gtcataacgc
     8521 tgccctgcag tgcatcatat tcctttgcct tctctgcaag ctcatccgca gatgcatccg
     8581 cgtacatgat ctttactgca agatccgcat ccatcatgcc gaccttcgcg tccggccatg
     8641 catatacgaa atccgcaccg atagacttgg aattcatagc aacataagcg gtaccgtatg
     8701 cctctcccgt gatcaggttc accttcggac atgtagctcc cgcaaatgcg gaggtcagat
     8761 gagcaagtgc ctttgcaaga cgcttttcag agcacttgca tgccttgtag cccttgacat
     8821 ttgtcagagt cagtaccgga atctcgaatg cgtcgcagaa agatacgaac tctgctgcct
     8881 tctcacatcc ctttgcagaa agaacattgt caaacttctc gctctctttg ccctcttcgt
     8941 cgtataccgt tgtgcagttt gcaactgcgc cgaccgtcat accgtttaac ttgataaatc
     9001 cggtcaccat atctctggca tagcctgcct ttgtctcgaa gaatgtatgg ctgtccgaaa
     9061 tctcactgag aagatatctc ggatcaccct tcatggcatc catgctctcg catgcacggt
     9121 tcaggtcatc cgcacactcg tctgtgtaga catctccctc gttgttgagc ggaagcatgc
     9181 cgaccagctc acggatgtct gcaaggatct catcctctgt tcccgtcgcg tcgatgcagc
     9241 cgttctcatc tgcctggaat gccgcagatg atgtgtcgca cttctcgatg cggtttccgt
     9301 caattgcgtt cggagaattc acaaacatct ttcctttgga ttcttcgata aaagcaaaat
     9361 cagaaagtgc cggtaccact gccagtccac cgccgcagct gccgaatacg gctgaaatct
     9421 gcggaaccac gccggatgct gcaacttctt ttgcatagat cagtccgaag ccatcaagcg
     9481 catctacaga ctcctgtaaa cggactcccg cgcaatcgat aaagccgatc accggtgctc
     9541 ccatcttcat cgccatgtca tacactgcag cgatcttctt cgcatgcatc tcgccgattg
     9601 ttccgtttaa aacagaagcg tcctggctgt aaatgaacac cagattgccg tcaatcaggc
     9661 cgtgtcctgt gatgactccg tcggaaggag tatccgttgc tgcaagatta aaatctgtgc
     9721 ttcttgcggt tacgagagaa ccgatctcaa tgaaactgtt ctcgtcgact aacctggtga
     9781 tgcgctgcat agccaggcta tcattgctac tattcattct ttttgccctc catctataaa
     9841 ttgttgtcca catccatttg ggatgcggct tcatagtgaa tgatgtaaat ccatgcgtct
     9901 ttgtataaaa attcaacaaa ttacgctatg ttaaattata attgcttttc tgcaatattt
     9961 caagtaaatt gttaattttt tgacgctttt tgtttgtgtt ttttattcga tccagagaag
    10021 ccgaagcacc tgccccagac accacggata atcgatcttt ccgattgtct ccccggctac
    10081 cacacatcgc tccgcgagcg tctcctcccc cagcatataa caaatcttcc cgatgtaatc
    10141 tccgctcttc accggtgcat acagctggtc tgcaatctca tacttaagcg taacctcact
    10201 gcttagcggc gccaggatac tctcctcccc tgcatagttc ctgacaactg gttttaaata
    10261 caccgtttcg ccgatttgtc cgccctgtcc gtcccgcacc tctatgggcg caagctccgc
    10321 ttcgtctggc tcaatctgca gcagattgat ctttttgaac tgctccaatc cgtaattcat
    10381 gagttttctg gtgtcggacc acttataggt cttgttgttc ggccatccac aggcgagcag
    10441 cgccacgatc agcgttttgt cctcccgctg cagcgctccg acatagcagt atccggcggt
    10501 tccggtaaat cccgtttttc cggaaagcgc cccttccatc atctgcaaaa atgcattgtg
    10561 gttcgtgcac tggtacgtgc atttcccctc tgcatcagaa aaagaatact gcgccgtccg
    10621 tgtaatctcg agaaattcgt cgctttttaa cgattcctta atacaatatt tcataatctt
    10681 agcaaggtct gccgccgtcg tgtgatgaaa cccggcatca tccttcgcat ccagtccgtt
    10741 cggtgtaata aagtagctgt cctcacagcc gagttcctct gccttcgcat tcatcagcgc
    10801 ggcaaatccc tgcacctccc ccgccgcaaa ttccgcgatg gccaccgcac agtcattgta
    10861 ggattccagc atcagaccat ataaaagatc cctcagataa aactgttgtc cctcgtgcat
    10921 ccccagatgt accttcggct gggacgccgc attttttgac accgtaacca cgctcgccgg
    10981 atcacagttt tccagtgcca cgatacaggt taaaatcttt gtcgtactcg cattcgccat
    11041 cgcttcatgc ccgtttttct catagagaat tcttccggaa tccgcatcca tcaaaacggc
    11101 agattttgcg tacagttccg actctgccgg cacatcctgc gcccggacac gcacaggcga
    11161 aaaaataagc aagctcatac ttaacaatag agaaagaaag cgtcgataca tgccattctc
    11221 ccaaaatgac ttcactgatg tatatgcgtc cctcattttt tgcagaacag aaacggtatg
    11281 taaaaaggaa ctgccgcaat aagcatatcg tgctttgata agtaatatta ttagaaacac
    11341 acttggggat ttcatgtgga aatgcagatg gaatattcgt tggagaaaaa tgtgagcatt
    11401 tcttccggct g
//
