LOCUS       gnlProkkaLJKGGHGH_4    17577 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LJKGGHGH_4.
ACCESSION   gnlProkkaLJKGGHGH_4
VERSION     gnlProkkaLJKGGHGH_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 01:52:13
            Original ID  :: gnl|Prokka|LJKGGHGH_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17577
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17577
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6989:7577]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6990..7577
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..17577
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17577
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(1245..2210)
                     /locus_tag="ctg4_1"
                     /transl_table=11
                     /translation="MINLKIDPEFQSQIPPLTDDEFKQLEENILKEGKLLSPLIVWNNT
                     LVDGHNRYAILQKHPEIYFSTMPLRFENREEAIAWICRNQLGRRNLSPEQKRYLLGKQY
                     EAEKKAAKIFRGNQYTLAKKSGGDHGDNHHSGKKTCDRIAEENGVSRASVLRASHYTRG
                     IDIADNLSPGIKQKVFSGEVKFTHEEMSKLVQASVEHRSDVLAQILHPEALEVLESASA
                     EFEPEKAEPVPMPTPQTEEFRCYHVPDEFMKVYKSLSRATEMMKNSWKKTLKNNPSYFT
                     DPEKQKVLRFAMQRPANYLTEIETYLEKALAEALEEEKTA"
     CDS             complement(2223..3755)
                     /locus_tag="ctg4_2"
                     /transl_table=11
                     /translation="MATLKHIASKNSDYSAAETYLVYQHDEFSGKKILDEQSRPKLRES
                     YILDTLECGEASFAMACLLANRKYDKNNHPDDIKSHQYIISFDPRDAAENGLTMEKAQA
                     LGLNFCKENFPGHPAIVCTHPDGHNHSGNIHVHIVIGSVRTREVERKPYMQKPRDWREG
                     MKHSSTAQTMRHLRVAVMEMCQDAKLYQIDLLSSKKRVSEREYWMKRRSQMKLDRENAA
                     LLAAGQQPTQTEFETAKETLRKQISDVLDNAASFEDFSDRLLQQYGITVKKSRGRLSYL
                     PAGRKKFIRAKHLGDNYDKEAVLATLTANAEHKTKVQSKQDTIGKLIDIQSRMTEDKGI
                     GYKRWITKHNLKAMAQTLIFLEEKGLTDEVALDQRITELDTKFHESLAVVKDLETRMAD
                     NKTLRRHAAAYTSTKNIAQQLKAAKRPAAFEEQHRAELTAHRAAAAYFKANDITKLPSP
                     KKLEAEYAQLASEKAQFYEQYKEAKNELLKLKTAKQNVASFFREEEPAQQER"
     CDS             complement(3727..4161)
                     /locus_tag="ctg4_3"
                     /transl_table=11
                     /translation="MNKTNVKTKPSTTHRHDTPNNKTHIIKFRVTETEKMELQCTAKLL
                     HLSLSTLIRRALHNAKIERTVVVAGGGEETLTAVSTLLAQCSRVGGNLNQLARHFNSGG
                     ADTEQLRAKLLDELADLTAFRLNAEKVLGKLYGNAEAYRL"
     CDS             complement(4847..5227)
                     /locus_tag="ctg4_4"
                     /transl_table=11
                     /translation="MNYYLRIAERNNINVKLDVTIPEVLTISSLSLSIIIGNTFDNAIE
                     ACCDLPAEQRIIHLQLRKQYRSLFYRLENPYSDTSRGIRIGEYHGYGLKNINRIVQENH
                     GDFYTKKKDGVFTVQVRLNCEN"
     CDS             5309..5653
                     /locus_tag="ctg4_5"
                     /transl_table=11
                     /translation="MKFFGITVFCNCLHRQDVFLHIMPQRTDFFLAFFELLVVFHLKIV
                     LLFVELNFEFFQFIFPESFHIEHDQDVYKEKHRHKTDHIIREILIRSMILCHITDSNTC
                     DLNRNDRQQP"
     CDS             complement(6112..6810)
                     /locus_tag="ctg4_6"
                     /transl_table=11
                     /translation="MLKYHVAVCDDEKSDLDGIVQSVQQYDVQGCFDIETYMDGNELLS
                     ELQMQKKSFDLLLLDIEMPSNGFQLAQSLIQMEKHPLVVFVTKRHEYAVQGYGIAFRYL
                     VKPLDQTLFAAAMDAVLQELNSKHFTIEYDGVTMSLETSDIYFLESHGHKVLIHCKEQD
                     LTLRMSIPEALEQLPKRCFVSPHKSYLVNMEHIVYATGTAVFLSSGHQLPISRRKRQEF
                     NQIFNAYLGR"
     CDS             6990..7577
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_7"
                     /sec_met_domain="AgrB (E-value: 1.1e-35, bitscore: 114.4,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWERTLSQKSVRLFCEQKVIDEAKADAYVYGYELLISSVVSVLLV
                     VLIAVVCGDVRYALSFLIGFIPQRIYIGGYHATSHTRCYLAFSGLALICILLSKAIAAN
                     HLFRILTTAALLVISIFLSPIEAKNKPLSEKKRSSYKMVASVLSSIDFLLAIFNVLPYT
                     RHVVCYYLSKWVLIVFSTIPLVQQKFNANFCR"
     CDS             7822..8586
                     /locus_tag="ctg4_8"
                     /transl_table=11
                     /translation="MKDVSRREFLKTLCLGITVAALQNLPMTTAFADSAISKTKIISKS
                     DRENLVATVARTVQVSYKIDKNTIIEVTRFTDIDGQNVTLNRSVKEDGTGELVYTKAQK
                     TKKSKLTNQSYDVFLKLATSKSMPQTRGATVGSDVTGSQYKHIFVSNLSYTIDNTAIAQ
                     IEIGGVETAASLLITGLHLPGSTAVTVGSFLVSVVLATSPSKVVINQSLYEVHFAYDNS
                     YYTHCYHDILYSYDSGGHLMDTTKSYHQAVGG"
     CDS             9625..9981
                     /locus_tag="ctg4_9"
                     /transl_table=11
                     /translation="MEGKTDKISQKYLTEETITEYAKRWGKLLNENTSMRIWHANDVKS
                     VNIDYFDQRIISLVSRIPISVGELTADVLKAISAPVSDWYVMKRIEALLKKGVLQVVIP
                     NKIFYNTIVQLNEE"
     CDS             10180..11739
                     /locus_tag="ctg4_10"
                     /transl_table=11
                     /translation="MTAVIYARYSSDNQREESIEGQIRECTAYAEKNDITIVKHYIDRA
                     ISAKTDNRPQFQQMIKDSDKKLFDIVLVWKLDRFARNRYDSARYKTQLKKNGVKLMSAT
                     EIISEGPEGIILESVLEGYAEYYSADLAEKVVRGQTENILKGRCNGGRGTFGYTLDSER
                     KFHIDPLASPFVLESFTKYRDGLTMKEIRDWLNENGIKNPVGGEFTYNSVEHMLKNRRY
                     IGELKFRDVVVPDAIPPIVPLELFDDVQEKIAKNKKAPARRKAEDDYLLTTKLHCGCCG
                     ALMFGESGTSRTGEVHRYYKCATAKKKKGCKKKTVRKQWLEDLVVNQTMQLVRDDAAME
                     SIIAKVMELQDRENTNLPLYEKQLRDAESGIQNMLNAIQAGILTSSTKERLEQLEETKR
                     ELEARIAEEKLAKPKVTEEFIRFWLLRFRKLNMNQKDQRQALVDTFINSIYLYDDKVLI
                     TFNYKEGTQTVTFGEATEVASEGNGSDLDCFTAPRTAAQVMCSSPFYYFIESILQKQRS
                     AL"
     CDS             11801..13162
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 287; E-value: 3.7e-87)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_11"
                     /transl_table=11
                     /translation="MSSQTNTLTEGPLAKQIFLVSLPLALSNLLQVLFNMSDVAVVGRF
                     AGSTALGAVGSTSTLVTLFTGFLIGLSNGINVLVARFYGARHPKDVEKTVHSAAIISAV
                     AGVALLLIGLLGSPAMLRLLNTKEDLLPGAILYLRVYFLGMPALALYNFGNAVFSSIGD
                     TKKPLLYLSIAGALNIALNLFFVIVCDLSVVGVALASAISQCVSAFLILRALTRVQDCY
                     ALDPHKLQLDPVQAKSILALGVPAGLQNAIFAIANLFIQAGVNSFDSLMVKGNSAAANA
                     DGLIYDCMAAFYMACASFMSQNYGAGRPDRVKKSYFISLGYSFGVGLVLGAALFFCGPA
                     FLALFTTETAVIDAGMKRVAVMAFAYCVSAFMDCTIAASRGLGKTVVPTVIVVLGSCVF
                     RVIWVYTIFAHFHTIPALYLLYPCSWILTALAEIAYFASCYKRAMAIFRKPAAA"
     CDS             13550..13660
                     /locus_tag="ctg4_12"
                     /transl_table=11
                     /translation="MTMDNVFQLFILIGGTVGVTFTISWAIFQEIHNNKK"
     CDS             complement(13912..15825)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_13"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.9e-09, bitscore:
                     28.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 7e-13, bitscore: 40.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKISRRNFMRGAAVGTMGAAAAGLLTACGNSASSTTGAPASSAA
                     SSAASSAVTKPSSPVDGKYVTKAMGHESWVHVATTFFDGKITACEVLSHEETIGIGNYA
                     CSRIPAAIVEHQSVNVPNLRGSSITSMAVKAAVKEAIELAGYNVDDFSKEVTIAASNEV
                     IEEEADVVIMGAGTSGLTCACRLLEAGYSVILVEKRDIPGGSMSMTYGGVATAGSKLQY
                     NYDVDGSFRSSAMGTLEGMMNFWQTMEKYHRTEFFNGEMPYMTKQYTVAGDLVDWMAGI
                     GIGFNTMGNYESATQYGASTPYLAPGCYEGGAGYAMMFMAQRVEKYEKGKIIYSTSVTD
                     LIKDESGRVVGFHAKGENGASYTLRGKAVCLASGGFAKNPEMLKKYSPDYADFFFNCAS
                     SMTGEGIQMGIDAGGYVECENRALPAFLSSYKSKFELAFIHQSAPGIMVNIKGDNIGNI
                     VSDNHYTMAKAKLNKDNGDTFYYVFDESSAVKLRDSESYGFNGYVAMFEKGEAVHYDSV
                     EKASEELNLPNLADAIEANNAAALAGEPDEFGRRNCPYIETRDGLWAIRVDPTFYLTTA
                     GLAIDTDCHVLTEDKKAIPGLYAAGDVCGSIEEKDAKQYGMGFDAALTYGYIMGETLKK
                     EI"
     CDS             16051..16968
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 141; E-value: 7.8e-43)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_14"
                     /transl_table=11
                     /translation="MTIYQLECFIAVAEELNFSAAAERLFTTQPAITYQINALEKETGL
                     HLFERTTRRTKLTAAGQSFYLDMVQMTSFGRQALKKAQDIQDADRSHLTVGLRQLFDYS
                     TFSSILAQFQHQFPNACVDVVPQDNRRPLEQLRSGQLDIGFFYATEHSRDRDISFTPLF
                     ALGYHVLMNPNSPLADRRALHLADLKGQSVVSSGAFDSFLSACQGPSLEQLAQVGVDCS
                     KITPSFEGALIMIQMGTAMSIVPCLPTAVIPGIVKVPLLDFPPVTVEIAAMRHAPRLEV
                     QSFIEIAKQKYAHHPDPLRMEALI"
ORIGIN
        1 gagagcaaga atcgtcccgt ggccacaaat tttcaattct tgaaaattct tgcccttttg
       61 ggacagcttc ttgttggggc gtgcctgccc caaaccctgc ttaggagtga gtgcaatata
      121 ctaggaattt atttattgct tgcatcggtt ttgtcgtttc cctttttctt acgagacaaa
      181 cctaaacaaa gatgcgtcga gccaaggcaa agaaatgatg aaccaagaca caaccataca
      241 acagccatag aattatcatt tccacttatg aagctaataa gtgaagccat atataacaga
      301 gcagaagctg catagaataa gatagatttc ttggtttctt ttttcataaa taatcgcctc
      361 cacaaatcga tttgttgagt caattatacc acgttcttta tcgaaattac accctctaca
      421 tgggagaact tggccgattt actgcgtacg tgcgtaccca tcttccgtat acacgtatgc
      481 ggcgatttgc ccgaaacgca ctctatacag ccgttccccc tcggagagcc cactacactt
      541 tgcagaccac agggatgaaa gtgtcatagt gggttattac acttccgcag aagtgccttc
      601 tcctcgccgc agacagccgg gtgtgccttt tgtgagagct ttctgtgcgg cgaatctaca
      661 tcgcccacag gcgatgtaag cagggattcc aaaggggcgc agcacccttg gcacacgact
      721 ttggtacaaa gtctagtgtg ttacaccttt ccagaggtgt atacgttcct gaaatgcaaa
      781 aagccccata cccaacacct taacggtgcg gacatgggac ttgatgcttc ctcggcctag
      841 ccgggtactc cgtaaccaat cctgacaggc agttgccgtg tcatttttcg aaaactgttt
      901 tacggatacc cagcaagtgg gaacttcctg tttttcgttg tttgcatgat gggcctgttc
      961 cgcctgccat gcggcaaact cccgctgacc ttcctcgctg ttccagcagg caaggatggc
     1021 cgggtagaat gcccgtgcca gacggtcgat gacttcatcg ggataagggg aagtgtttgt
     1081 ggactttttc tttttgttca aacgcacgct cctttgatcg tcccaccgtg gcaaagtcgg
     1141 gcgagaaaat caaagttcca atttttatca ggcgcaaggg cgcggaagtt ttccaccctg
     1201 cacttgcggc tggtggctca ttgatggctt acaagtgcct gtcgttatgc ggtcttttct
     1261 tcttcaaggg cttctgcaag agccttttcc agataggttt cgatttcagt caggtagtta
     1321 gcaggtcgct gcattgcgaa gcggagaacc ttctgctttt ccgggtcagt gaaatagctg
     1381 ggattgtttt tgagcgtttt cttccatgag tttttcatca tttcggtcgc acggctcaaa
     1441 gatttgtaaa ccttcataaa ctcgtccggt acatgatagc accgaaattc ttctgtttgt
     1501 ggtgtgggca tgggaacggg ttccgctttt tctggttcaa attctgcgct ggcagattcc
     1561 aacacttcca atgcctctgg atgcaggatt tgagcaagga catctgaacg atgctcgaca
     1621 cttgcctgca caagcttgga catttcttcg tgggtgaact tcacttcgcc ggaaaagact
     1681 ttctgcttga tgccgggaga gagattatct gcgatgtcga tgcctcgtgt atagtggctg
     1741 gcacgaagaa cggaggcacg gctgacaccg ttttcctctg cgatccggtc acaggttttc
     1801 tttccagagt ggtggttatc accgtgatca ccaccacttt tctttgctaa agtgtactga
     1861 ttaccccgaa agatttttgc agctttcttt tcagcttcat actgtttccc aagcagatag
     1921 cgtttctgtt cggggctcag gtttcgccgt cccaactgat tccggcaaat ccacgcaatg
     1981 gcttcttcgc ggttctcaaa tcggagcggc atagtggaaa aataaatctc aggatgcttc
     2041 tggagaatgg cataacggtt gtggccatca acaagtgtat tattccacac gatcaaagga
     2101 gagagcagct tgccctcttt caagatattt tcttcaagct gcttaaattc atcatcggtc
     2161 agaggaggaa tctgagactg gaactccggg tcgattttca gattgatcat acgcacactc
     2221 ctttatctct cctgctgcgc cggttcttcc tcccggaaaa aggacgcaac attctgcttt
     2281 gcggttttca gcttgagcag ctcgttcttg gcttccttgt actgctcgta gaactgtgcc
     2341 ttttcggatg ccagctgcgc atactcggct tccagtttct tcgggctggg cagcttggtg
     2401 atatcatttg ccttgaaata ggctgctgcc gcccggtgcg ctgtcagttc tgcacggtgc
     2461 tgttcttcaa aggctgcggg tcgttttgcg gcttttaact gttgtgcgat gttcttggtg
     2521 ctggtgtagg cagcagcatg acggcgcagc gtcttgttgt ctgccatgcg agtttcgagg
     2581 tctttcacta cggccagcga ttcatggaac ttggtgtcaa gctctgtgat tctctggtcg
     2641 agtgcgacct catcggtcaa gcccttttct tctaggaaaa tcaaggtctg tgccatggct
     2701 ttgaggttgt gtttcgtgat ccaacgctta tagccgatgc ccttgtcctc ggtcatcctc
     2761 gactggatgt cgatcagttt cccgatggta tcctgcttgg actgcacctt ggttttgtgc
     2821 tctgcgtttg cggtcagggt ggcaagcact gcttccttgt cgtagttgtc accgagatgt
     2881 ttcgcccgga taaacttctt tcttccggct ggcaggtagc tgagccgccc acggcttttc
     2941 ttgaccgtga tgccgtactg ctgcaagagc ctgtccgaga aatcttcaaa gctcgctgca
     3001 ttgtccagca catccgagat ctgtttccgc aaagtctcct ttgcggtttc aaactccgtt
     3061 tgtgtaggct gctgtccggc ggcaagcagg gcagcgtttt cacggtcgag tttcatttga
     3121 ctgcgccgtt tcatccagta ttcacgctcg ctcacacgct ttttcgagct gagcaggtcg
     3181 atctggtaca gcttggcatc ctgacacatt tccatgactg cgacacgcag gtgccgcatg
     3241 gtctgggctg tgctggaatg cttcatgccc tcacgccagt cacggggctt ttgcatatag
     3301 ggcttgcgct ccacttctcg tgtccggacg ctgccgatca cgatgtggac atggatattt
     3361 cccgaatggt tgtgtccgtc cgggtgggtg cagacgatag caggatgacc gggaaagttc
     3421 tctttgcaga agttcaggcc gagggcctgt gccttttcca tcgtcagccc attttcggct
     3481 gcatcccgcg ggtcgaagct gatgatatac tggtgactct tgatgtcatc cgggtggttg
     3541 ttcttgtcgt acttccggtt tgccagcagg caggccattg caaacgaggc ttcgccgcat
     3601 tcaagggtgt ccagaatgta cgattcccgc agcttgggtc tgctctgttc atccagaatt
     3661 ttcttgccgg aaaattcatc gtgctggtaa accagatagg tctcagcggc agagtagtcc
     3721 gaatttttag aggcgatatg cttcagcgtt gccatacagt ttacccagaa ctttctcggc
     3781 gttgagccgg aaggcagtca ggtctgcaag ttcgtccaga agtttcgccc ggagctgttc
     3841 ggtgtctgct ccgccggagt tgaagtgtcg tgcgagttgg ttcaggttgc cgcccaccct
     3901 gctgcactgg gcaagcagag tggaaacggc agtcagggtt tcttctccgc cgccggcaac
     3961 gacaacggtg cgctcgatct tcgcattgtg cagcgcacgg cggatgaggg tggacaggga
     4021 gagatgaagg agttttgctg tgcattggag ttccatcttt tcagtttccg tcacacggaa
     4081 cttgatgatg tgcgttttgt tgttcggcgt gtcgtggcgg tgggtcgtgc tgggtttcgt
     4141 tttgacattc gttttgttca ttgaacctcc tgtcgtttcg ctagctcctc ggtggagcta
     4201 tgtaagcacg acacgccgtt ctttcgcacc gcaaggtgcg aatatgagca gggtttgggg
     4261 caggcacgcc ccaacaagat cacttcggaa atgcagacgc attgcagaag tgaagtcccg
     4321 gtggagcaca acattttcaa gaattgaaaa tttgtggcca cgggacggtt cttgctctcc
     4381 accgctgcgc tcaaaacgca tttccgaaag ttgtttccga attgttaaga cgcaaaaata
     4441 agtagagagt tccgctgctc gtgtatgttg atcgccgttt gctccgaacg aagttcctgc
     4501 ccctgttttg cagcggcgtt ggccgaaaag ccggtatcac gctcggacgg ctcatgaaat
     4561 tctcaaggta cggcttcccc aaaaagaaaa taccgcccac gcagtacagg cgaaggattt
     4621 tgtcgggtga aacagacggc aaaatgatcg ggtgtgttgc ggggcggtaa atcttcgcag
     4681 gaaataaaac cgcacagaat cgtttcttta cagaaatcgc tgtggatttg ttgggaatga
     4741 taacataagt attgatgtgt gtcaacactt caggataatg aatacatcag atgaatgaaa
     4801 cacacaaagt acaagcaaaa gcaaagcaat gttttaggag aatgttttaa ttttcgcagt
     4861 tcaggcggac ttggacggta aacacaccgt ctttcttttt cgtatagaag tcaccatggt
     4921 tctcctgaac gatacgattt atatttttta gtccgtaacc gtgatactct ccgatgcgga
     4981 ttccgcgaga agtatcactg tatgggtttt ccagccgata gaagaggctt cgatactgct
     5041 tgcgcagctg tagatgaatg attctctgtt ccgctggcag gtcgcaacag gcttcgatgg
     5101 cattgtcaaa tgtgtttccg ataatgatgc tcaaagacaa cgatgagatc gtcaggactt
     5161 caggaatcgt cacatccagt ttgacgttga tgttattcct ttccgcaatt cgtaagtaat
     5221 aattcaaaag agcatcaaca acaggatttc cgaccgcaga aatatttgtg gaacgctcga
     5281 aaacatccgt ggcagcctgc gcaatcttgt gaagttcttc ggtatcaccg tgttctgcaa
     5341 ctgcctgcat cgccaggatg tatttcttca catcatgccg cagagaacgg acttcttcct
     5401 ggcgttcttt gagctgctgg tagtattcca tttgaagatt gtactgctgt tcgttgaact
     5461 taactttgaa tttttccagt tcattttccc ggagagcttc cacatagaac acgatcagga
     5521 tgtttataag gagaagcacc gccataagac cgaccatata atccgggaaa tactcatccg
     5581 cagcatgata ctgtgccaca taacagacag caatacttgc gatttgaatc gcaatgatcg
     5641 gcagcagcca taggatacgc agagcatttc cttttcggct gaaaaaatgt gagatcagga
     5701 ctacgagtgg aatttgaatc aggtttgaaa aaacaacata gaccaaccgt gctgccccag
     5761 cctgcattag aatgtcggta tccgggatac gcagcccaat cagaagcatt gcaagcactt
     5821 ccaccaaagc aatcagtgtg aagaaagctc cgcttgcaaa aaccgcctgc cacggtcgaa
     5881 cctcatagaa cagcaatgca aggaaaaatc cgccaactaa aagatagatc gtgcgctgcg
     5941 tcacccaatc cgggaataaa ctcaaagcac actgcccagc aatcaagagt gcaacatagg
     6001 catagaacca ccttgagacg ggctcctttt tgggaaacag ccgaccgata aaaagcagca
     6061 acagggcaat gttggcaaag ctccctgcaa actcaacgaa ataataaagc atcatcttcc
     6121 caaataagcg ttgaagatct gattgaactc ctgacgcttc ctcctgctga tcggcagctg
     6181 atgtccgctg gaaagaaaaa cagcggttcc cgtagcgtaa acaatgtgtt ccatgttgac
     6241 gagataactt ttgtgtggtg acacaaagca ccgtttggga agctgctcca aggcttcagg
     6301 aatgctcatt cgcaatgtaa ggtcttgctc cttgcagtga atcagaactt tatgtccgtg
     6361 gctttccaga aagtaaatgt ccgatgtttc caaggacatg gtaacaccat cgtattcgat
     6421 cgtgaaatgt ttggagttca gttcctgaag gacggcatcc attgccgcag cgaacagcgt
     6481 ctgatccaaa ggtttgacaa ggtagcggaa tgcaatgcca tatccctgca cagcgtactc
     6541 atgccgcttc gtgacaaata ccaccaaagg atgcttctcc atctgaatca aagactgcgc
     6601 cagctgaaaa ccgttggatg gcatctcgat atcgagaaga agcagatcaa aggatttctt
     6661 ctgcatttgc aattcgctca gaagttcgtt tccatccatg taagtttcaa tgtcaaagca
     6721 gccttgcaca tcgtactgct ggacgctttg aacaatgcca tcaaggtctg atttctcatc
     6781 atcgcagact gcaacgtggt acttcagcat ttcgacaacc tccacaaaat aatgtcctgc
     6841 tactattata gactgtgcaa aggctcctta caagtagcct gacctaccac ttttgtcacc
     6901 agaacgacca gttttgccaa acctcttgat tttgctgaaa tttatgatac agtgaagcaa
     6961 aaatcagaag ataaggtggc gcaactgcaa tgtgggaacg cacgctgtct caaaaatcag
     7021 tccgtctttt ctgcgagcaa aaagtgatag atgaagcaaa ggcggatgcg tatgtctatg
     7081 ggtacgagtt gctcatatca tctgttgtga gcgttctgct tgttgtttta atcgctgttg
     7141 tgtgtggtga tgtgcggtac gcactttcat ttttgattgg gtttatccca cagcgaatct
     7201 acattggcgg ataccatgca acatcgcaca ccagatgcta tttggcattc tccggactgg
     7261 cacttatctg cattttgcta agtaaggcaa tcgcagcaaa tcaccttttc cgtatcctga
     7321 caacagcagc tcttttggtc atctccatct ttctctctcc tatcgaagca aagaataagc
     7381 ctttaagtga aaagaagcgg tcaagttaca agatggtcgc atctgttctt tcgtcaatag
     7441 atttcctgct tgccattttt aatgtgcttc cgtatacacg tcatgtagtt tgctactatc
     7501 tctccaaatg ggtattgatt gtattctcaa caattccttt ggttcaacaa aaatttaatg
     7561 ccaacttttg tagataggga ggtgataaca tgaaaaaaaa caaatgggtg ctgcttctta
     7621 tcgcttttgt tgcatttttg gtattggttt attttattgg tgcttgcctt aatgcaacgg
     7681 cagaggcatt gacaattatt tcgctctgca tcggcatact ggtcatttat ttagtcgtaa
     7741 aagcaatcaa atcaaaataa ggaaaggaaa atgtgatcat gagtacaaga aaattcatca
     7801 aaaaacttac ggcgatagaa tatgaaagat gtatctcgaa gagaattctt gaaaacttta
     7861 tgtttaggca taacagtagc cgctttacaa aatttgccaa tgacaacggc ttttgcagac
     7921 agtgcaatca gtaaaacaaa aattatttct aaaagcgacc gtgaaaattt ggtggctact
     7981 gttgcaagaa ctgtgcaagt gtcctacaaa atagataaaa atacgatcat tgaagtaact
     8041 cgctttactg atattgatgg acaaaatgtt accttgaacc ggagcgttaa agaagatggt
     8101 acaggtgaac ttgtctatac gaaagcccaa aaaacgaaaa aaagcaaatt gaccaatcaa
     8161 agctatgatg tctttttgaa attagcaact tcaaaatcta tgcctcaaac aaggggagcc
     8221 actgttggaa gtgatgttac aggatcacag tataagcata tatttgtatc aaatctcagc
     8281 tatacaattg acaatacggc gattgcgcaa attgagattg gtggagttga aactgcagca
     8341 agccttttaa ttactgggtt gcacttgccg ggaagcactg ctgttacggt tggatccttt
     8401 ttggttagtg tggttctagc tacttctcca tcgaaagttg ttataaatca atcgctgtat
     8461 gaagtccatt tcgcatatga taatagctac tatacccatt gctatcatga tattttgtat
     8521 tcgtatgatt ccggtggaca ccttatggat actacaaaat cgtaccatca agctgtggga
     8581 ggctaagaat gaaaaaaggc aaaagcaact tttttcttat tgctcctttt gccctttggg
     8641 gctgcatttc agtatggact agtaatcttg tccgattgac agataaaagc gcagtacctt
     8701 atgcttgggc ttctttgttt ttctcatatg gaatcgtagc agtgcattat atccaagtgg
     8761 cagtatcctc caaaggctgt aacaatgccg aaaacgaaaa aattgcatgg gttcagcttg
     8821 ggctttcaac tttgttcttg atagtagctg ttgttctagc tattcaatga aggaaagcaa
     8881 agtaatcacc caaagcagtg taaggtaaca tggagagttc tttatacaaa ggccaatgga
     8941 ttgggctttt atatgagtgg aactaccgtc ggtattggcc cggatttaat aaaaaatgtt
     9001 tcaggaacgg attactacac gagctattcc gataacatcg aacgaagctg cccattttca
     9061 acgacagcac tagttccaga acaaagtata tataatacaa cctatacata tgacttctat
     9121 gatgttggaa cttatcttga ttgcagcgtt gggtgttatt ttggagtggt tggctcaagc
     9181 aaaccaatct attggagtgc aactacacaa gttaccatcc cgaaattatg attttgacca
     9241 gctatggatg aaattgtttt tgaacccagt gatgtcaata tgttagcagc tttaggcatc
     9301 gtcgaaagtg taaagttgtt tccgtttatg ttatcaatgg gagaacttca atatgcttgc
     9361 gattcagaat atcgttgcaa acaattcgtg aattgccttt cagaatatta tcctgacagc
     9421 caaattgaag ctagacaact gtggtcgaaa tatcatggta cagcgaatgc ggttcaatgt
     9481 gatatgataa atcataagcc actgcgtgtt tgggtcagga gttctgccga ttgttggtgc
     9541 ggcatttatt atatttgtta ctatgcagca aagtatggta caaatagaat tttgcttgca
     9601 tccagagaag gtctgaaaga atttatggaa gggaaaaccg ataagatctc acaaaagtat
     9661 ttgacggaag aaactattac tgagtatgcc aaaagatggg gaaagctatt aaacgaaaac
     9721 acctccatgc gtatttggca tgcgaacgat gttaaaagcg ttaacataga ttatttcgac
     9781 cagagaatta ttagtttagt atcgagaatt cctatttcgg ttggtgaact taccgcagac
     9841 gtattaaaag cgatttctgc tccggtaagt gactggtatg tcatgaaacg catagaagca
     9901 cttttgaaaa agggtgttct tcaagtcgtt attccaaaca aaatctttta taataccatc
     9961 gtccagctaa acgaagaata aaggaatccg agcaagtcgg cccaacagtc acctcatttc
    10021 aacgagaggg gtggctgttg ggtcaattgt tcaaaaagaa aaactgaaga taataaaaag
    10081 tcttgatttc tccatcaaaa catggtatat acattatacg aaacagtgct ttgaaagaac
    10141 gctccaccgt tcaatgatgt agaatgagag gtgtccgtca tgaccgctgt aatctacgcc
    10201 cgctattcca gtgataacca gcgcgaagaa tccatcgaag gccagattcg tgaatgcacg
    10261 gcctatgccg aaaagaatga catcactatc gtcaagcact acattgaccg cgccatctct
    10321 gccaagacgg ataatcgccc tcaattccaa cagatgataa aggacagcga caagaagctg
    10381 tttgatattg ttctggtctg gaaacttgac cgctttgccc ggaatcgcta cgacagtgcc
    10441 cggtataaga cccagctgaa gaagaacggt gtcaagctca tgtcggctac ggagatcatc
    10501 tccgaggggc cagagggtat cattctggaa tcggttctgg agggctatgc agaatactac
    10561 tctgccgacc ttgccgaaaa ggttgtccgt ggacagacag agaacatcct gaaaggccgc
    10621 tgcaacggtg gtcgtggaac gtttggatat acgctggatt ccgagcggaa atttcacatc
    10681 gacccgcttg cctccccttt cgtgctggaa tcgttcacga agtatcggga tggcctcacg
    10741 atgaaagaga ttcgggactg gctgaatgaa aacggcatca agaacccggt cggaggcgaa
    10801 tttacttaca acagcgtgga gcacatgctc aaaaaccggc gttatatcgg agaactgaaa
    10861 ttccgggatg tggtcgtgcc ggatgcgatt ccgcccatcg tgccgctgga actgttcgat
    10921 gatgtgcagg aaaagattgc caaaaacaag aaagcccctg cccgaagaaa ggcagaggac
    10981 gattacctgc tgacaaccaa gctgcactgt ggttgctgcg gtgcgctgat gtttggcgaa
    11041 agcggcacaa gccggacggg agaagtccac cgctactata aatgtgccac ggccaaaaag
    11101 aagaagggct gcaagaagaa aactgtccgc aaacagtggc tggaagatct ggtggtgaac
    11161 cagaccatgc agcttgtccg ggacgatgcc gccatggaat ccattatcgc caaggtcatg
    11221 gagctgcaag accgagagaa caccaacctt cctctctatg agaaacagct ccgggatgcg
    11281 gaatcgggta tccagaatat gctgaatgcg attcaggctg gaatcctgac cagttccacc
    11341 aaggagcggt tggagcaact ggaagaaacc aagcgtgagc ttgaagcccg cattgcagaa
    11401 gaaaagctgg caaagcccaa ggtcacggag gagttcattc gcttttggct gctgcggttc
    11461 cgtaaactca acatgaatca gaaagaccag cggcaggcac tggtggacac gttcatcaat
    11521 tcgatttacc tgtacgatga taaggttttg ataaccttca actataaaga agggacacag
    11581 accgtgactt ttggagaagc gacggaagtt gcatccgagg gaaatggttc ggatttggat
    11641 tgctttactg caccaaggac tgctgcacag gttatgtgca gcagtccttt ttattatttt
    11701 atcgaatcca tcttgcaaaa gcagcgcagt gccttataat agaggctgtg ccccggtgtg
    11761 cgcgggtacg gttaggatgt ataggataaa ggaaaaaagt atgagttctc aaacgaatac
    11821 gctgacggaa ggccctctgg ccaagcagat ctttctggtc agtctgccgc tggcgctttc
    11881 caacctgctg caggtgctgt tcaatatgtc ggacgtggcg gtggtggggc gctttgccgg
    11941 gtctacggcg ctgggcgctg tgggctccac cagcacgctg gtgaccctgt tcaccggctt
    12001 tctcatcggt ctgagcaacg gcatcaacgt gctggtggcg cgtttttacg gcgcgcgcca
    12061 ccccaaggac gtggaaaaga ccgtccactc ggcggccatc atcagcgctg ttgccggtgt
    12121 ggcgttgctg ctcatcggcc tgctgggctc ccccgccatg ctgcggctgc tgaacaccaa
    12181 ggaggatctg ctgcccggcg cgatcttgta tctgcgggtg tattttctgg gtatgccggc
    12241 gctggcgctg tacaacttcg gcaacgcggt gttcagctcc atcggcgaca ccaaaaagcc
    12301 gctgctctac ctttctattg ccggtgccct gaacattgcg ctgaacctgt tctttgtcat
    12361 cgtgtgcgat ctgagcgtgg tgggcgtggc gctggccagt gccatcagcc agtgcgtttc
    12421 cgcgtttctg atcctgcggg cgctgacccg ggtgcaggac tgctacgcgc tggacccgca
    12481 caaattgcag ctggaccctg tgcaggccaa gagcatcctt gcgctgggcg tgcccgccgg
    12541 gctgcagaac gctatttttg ccattgccaa cctgttcatt caggcaggtg tcaactcctt
    12601 tgactctttg atggtcaagg gcaacagtgc tgccgccaat gcagacggcc tgatttatga
    12661 ttgcatggcg gccttctaca tggcctgcgc cagctttatg agccagaact acggcgcggg
    12721 acggcctgac cgggtgaaga agagctactt catcagtctg ggctactcct tcggcgtggg
    12781 gcttgtgctg ggcgcggcgc tgttcttctg cggaccggcc ttccttgcgc tgttcactac
    12841 cgaaaccgcc gttattgatg ccggcatgaa gcgggtggct gtgatggcct ttgcctactg
    12901 cgtctccgcc tttatggact gcaccatcgc cgcctcccgc gggctgggca agacggtggt
    12961 gcccaccgtc atcgtggtgc tgggctcctg cgtattccgg gtgatctggg tgtacaccat
    13021 ctttgcccac ttccacacca tcccggcgct gtacctgctg tatccgtgca gctggatact
    13081 gaccgcgctg gcggaaatcg cctattttgc cagctgctac aagcgtgcaa tggccatctt
    13141 ccgcaagccc gcggcggcgt aaggggacga tttggaatgc gcgccgcgtg tgctttgcgc
    13201 atattcagtg gaagaattat ttttaatttc gggataccgg agcgtctgcg gacactccgg
    13261 tatccctttt ttcacgggag gggtcacaaa ggcaaactgc atttgcagcg cttgtttcct
    13321 gcggaagcag tcgcgctgcg ggcaagcttt ttgtagtttt cagcggactg aactgaagct
    13381 cttgattgta ttgcctgcaa aaatatgcta caataaaaac accgcccaag ggcggtgaac
    13441 tggtgctgat tgcataaagg tggtctagct tcctccggca agcttccggg ggctgtgaaa
    13501 ccttattgtt ttgttccccc ggacgcaaac gcgaaagggg ggatgctgca tgacgatgga
    13561 caacgtcttt caactgttca tcctgatcgg agggacagtc ggggtcacgt ttacgatctc
    13621 atgggcgatc tttcaggaga tccacaacaa taagaaatga ccgcccctgt ctaccaaacc
    13681 gtggcggtca ttcttatgat taactgaacc ggttgggagc tggccattgc agtcagcacc
    13741 ttttccattt caagtatacc cagtttcggc agggatgtca agggcacttt gcacgacact
    13801 gtgtcgtttc tgaacagggc gcaaactctc gctcctgcac gcaaaagggc tgctgcacgg
    13861 tttgtgcagc agccctttgt ttatgctttt gtcagggggt cagagcgcag ctcagatctc
    13921 cttcttcagg gtctcgccca tgatgtagcc gtaggtcaga gcggcgtcga agcccatgcc
    13981 gtactgcttg gcgtccttct cctcgatgga gccgcagacg tcgccggcag cgtacaggcc
    14041 ggggatggcc ttcttgtcct cggtcaggac gtggcaatcg gtgtcgatgg ccagacctgc
    14101 ggtggtcagg tagaaggtgg ggtcaacgcg gatggcccac agaccgtcgc gggtctcgat
    14161 gtaggggcag ttgcggcggc cgaactcatc gggctcgcca gccagagcgg cggcgttgtt
    14221 ggcctcgatg gcgtctgcca gattgggcag gttcagctcc tcagaggcct tctccacgct
    14281 gtcgtagtgc acagcctcgc ccttctcgaa catggcaacg taaccgttga agccgtagga
    14341 ctcgctgtcg cgcagcttga cggcagagga ctcgtcgaac acatagtaga aggtgtcgcc
    14401 gttgtccttg ttcagctttg ccttggccat ggtgtagtgg ttatcggaga cgatgttgcc
    14461 gatgttgtcg cccttgatgt tgaccatgat gccgggggca gactggtgga tgaaggccag
    14521 ctcgaacttg ctcttgtagc tggacaggaa ggcgggcaga gcgcggttct cgcactccac
    14581 atagccgccg gcgtcaatac ccatctggat gccctcgccg gtcatgctgg aagcgcagtt
    14641 gaagaagaag tcggcgtagt cggggctgta cttcttcagc atctcggggt tcttggcaaa
    14701 gccgccggag gcaaggcaga ccgccttgcc gcgcagggta tagcttgcgc cgttttcgcc
    14761 cttggcgtgg aaacccacaa cacggccgct ctcgtccttg atcaggtcgg tgacgctggt
    14821 ggagtagatg atcttgccct tctcgtactt ttccacgcgc tgtgccatga acatcatggc
    14881 gtagcctgcg ccgccctcgt agcagccggg tgccagatac ggggtggaag cgccgtactg
    14941 ggtagcgctt tcgtagttgc ccatggtgtt gaagccgatg ccgatgcctg ccatccagtc
    15001 caccagatca ccggcgacgg tgtactgctt ggtcatgtag ggcatttcac cgttgaagaa
    15061 ctcggtgcgg tggtacttct ccatggtctg ccagaagttc atcatgccct ccagcgtgcc
    15121 catggcagag ctgcggaagc tgccgtccac atcgtagttg tactgcagct tggagcctgc
    15181 ggtggcaacg ccgccgtagg tcatggacat ggagccgccg gggatatcgc gcttctcaac
    15241 cagaatgacg ctgtagccgg cctccagcag gcggcaggcg caggtcaggc cggaggtgcc
    15301 ggcacccatg atgacgacat cagcctcttc ctcgatgacc tcgttggaag cagcgatggt
    15361 gacctccttg gagaagtcgt ccacgttata accggccagc tcgatggcct ccttcacagc
    15421 tgccttgaca gccatagagg tgatggagga gccgcgcagg ttgggcacgt tgacactctg
    15481 gtgctcgacg atggcggcgg ggatgcggga gcaggcatag ttgccgatgc cgatggtctc
    15541 ctcgtgagac agcacctcac aggcagtgat cttgccgtca aagaaggtgg tggcaacgtg
    15601 cacccagctt tcgtgaccca tcgccttggt gacgtacttg ccgtccaccg gggaggaggg
    15661 cttggtcaca gcggaggaag cagcagagga agctgcggag gaagcgggag caccggtggt
    15721 gctggaagcg gagttgccgc aggcggtcag cagaccggca gcagctgcgc ccatggtgcc
    15781 cacagcggca ccgcgcataa agttgcgacg agagatctta gccataaggt tcgcctttct
    15841 ttttcttttc tcttcttttt tgcgtttttc ctgttccttc gtgcattttg aacattgata
    15901 cgattatagc aaagttttgc cccggtgtga aatacaaatt tgtgtcagaa tttatcaaat
    15961 ctctttataa atcgttttcc ctttacggcc tgtgcggaat cctgtataat aaagatgacc
    16021 agctttttac acaaggaggg gcgccattct atgacgattt accaattgga gtgctttatt
    16081 gccgtagcag aggagctgaa tttcagcgcc gccgccgagc ggctgttcac cacccagccc
    16141 gccatcacct accagatcaa tgcgctggaa aaggagaccg ggctgcacct gttcgagcgc
    16201 accacccgcc gcaccaagct gaccgctgcc gggcagtcct tttatctgga catggtgcag
    16261 atgaccagct ttgggcggca ggcgctgaag aaggcgcagg atattcagga cgccgaccgc
    16321 tcccacctga ccgtcgggct gcggcagctg ttcgattaca gcaccttttc cagcattctg
    16381 gcccaattcc agcaccagtt tcccaacgcc tgcgtagacg ttgtgccgca ggacaaccgc
    16441 cgcccgctgg aacagctgcg ctccgggcag ctggatatcg gctttttcta cgccaccgag
    16501 cactcccgcg accgggacat ctcctttacg cccctgttcg ccctgggcta ccatgtgctg
    16561 atgaacccca actctcccct tgccgaccgg cgggcgctgc atctggcaga cctgaagggg
    16621 cagagcgtgg tgtcctccgg cgcgttcgac agctttctgt ccgcctgtca ggggccgtcg
    16681 ctggagcagc tggcgcaggt gggggtggat tgcagcaaga tcacccccag ctttgagggt
    16741 gcgctgatca tgatccagat gggcaccgcc atgtccattg tgccctgcct gcccacggcg
    16801 gtgatcccgg gcatcgtcaa ggtgccgcta ctggattttc ccccggtgac ggtggagatc
    16861 gccgctatgc gccacgcacc ccggctggag gtacagtcct ttatcgagat cgccaagcag
    16921 aaatacgccc atcaccccga cccgctgcgg atggaggcgc tgatctgagg cgcagctgct
    16981 actgttcaaa agtcccctat gacccataga gttttgaata gttacttttt ctgcgccaaa
    17041 acacgcagaa cgatgcgctt tttgccccga ctcttcaaaa gtagccaaag ttttgaagag
    17101 tcgcaaacac aacgaaacta cgttactttt gaatactatt caatataaaa aagtggtaat
    17161 aatgtccgac tcttcaaaag tccccttata tcatagggct tcgccgcctg ttctgaacag
    17221 ccgcactgcc ctgtaaaagc agaaaaccgg acagcctgcg ggctgtccgg ttttttgtgc
    17281 tatcgaaagg ttttactgat aatcgtggtt gaggaacagg gccttgatga ccaccacctc
    17341 gtcatattcc tcctgctcca cctccacgtc cgcgttcaag gatttcaggc gtgccttgac
    17401 tgcatccagt gcctcgggca cggtgacggc gcggccttct tccacggcgt ccatcatctg
    17461 cttgagcacg atggggtggg cgtaccagct tttcaccggg aaagcgccgt gggggtagtg
    17521 cttgacatac tctgccatgg ctgcctcggc cttttcagca cgcttcatga tggcgct
//
