LOCUS       c00090_gnlPro..        13652 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ADNJJMLP_90.
ACCESSION   c00090_gnlPro..
VERSION     c00090_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 01:23:24
            Original ID  :: gnl|Prokka|ADNJJMLP_90
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13652
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13652
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1992:10777]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1993..10777
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13652
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13652
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             3..287
                     /locus_tag="ctg90_1"
                     /transl_table=11
                     /translation="EEEFSKLKKQADHGYMMDVENRRLKEELSTAKKEAIHWSNKYHDL
                     WYDVKPYLDALHRAPELVRSFLEKILAPKQERTMNVPQKNRKRGQDMEL"
     CDS             305..481
                     /locus_tag="ctg90_2"
                     /transl_table=11
                     /translation="LNKKKKSNKSGYPDEAIKTLARCFYPSMVEFFNSEEGQREYEEWL
                     KEQEALQALPVAA"
     CDS             complement(580..831)
                     /locus_tag="ctg90_3"
                     /transl_table=11
                     /translation="MKYDARACLFNMDTGCVELTLQDGRKISIDCTGVEDALDVTMAQR
                     SELDYLVYNDPLGYADLILNGDPEEYLKNAAGSHGLED"
     CDS             1275..1946
                     /locus_tag="ctg90_4"
                     /transl_table=11
                     /translation="MESTISAAPQISIDREKTLRSYRRYWVLRRAQDIVFSLLALILLA
                     PLALLISLAIVLDSPGDGAIFRQRRVGRDGKLFWLYKFRTMCPDAEEQLNELLSQNQMD
                     GPVFKIKGDPRITRVGRFLRKTSLDELPQLLNVLQGDMSIVGPRPALPREVELYSDYQR
                     QRLYVTPGLSCYWQIAPHRNEMSFDEWVALDMKYIQERSFWVDWKIIFLTVRAMLMKYG
                     E"
     CDS             complement(1993..3651)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_5"
                     /sec_met_domain="ILVD_EDD (E-value: 1.6e-223, bitscore:
                     732.8, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDNVTKGSERAPNRSLFYALGYTPEELERPLIGVVSAHSEIVP
                     GHMNLDKIADAVKAGVQMAGGTPILIPAIGVCDGIAMGHVGMKYSLASRELICDSVETM
                     LMAHQLDGLVLVPNCDKIVPGMVMAAVRMDVPAVVCSGGPMLAGTYGGEEVSLSKMFEA
                     VGAYKAGMITDEQLEDCTCNCCPSCGSCSGMYTANSMNCLCEAIGIALPGNGTIPAVYS
                     KRLQLAKHAGMAVMEMVRKGITARQIINERSIRNALTCDMALGCSTNTVLHLLAIAYEA
                     GVPIDLKLFNEISAKTPNLCHLAPAGPTHMPDLYAAGGIPAVQAELAKKGLLDLDVPTV
                     TGKTLGENIKGAHILNEKAIRPIENPYSQTGGLQILWGNIAPDGCVVKRSAVAPEMQQH
                     SGPARVFNSEEEAIAAIYAGKIVPGDVVVIRYEGPKGGPGMREMLNPTSALAGMKLDKT
                     VALITDGRFSGASRGAAIGHVSPEAASGGPIGLIEEGDTISIDIPNASITLEVSDAVLA
                     ERKAKYVAPEPNIKTGWLSRYARMVTSANLGAVLK"
     CDS             complement(3817..4836)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_6"
                     /sec_met_domain="IlvN (E-value: 8.4e-75, bitscore: 239.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.4e-65, bitscore: 209.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIKKYYDSDCNLGVLDGKTVAVIGFGSQGHAHSENLAESGVNVV
                     VGLRKGSAHWAKASEFAATHENFKVMEVEEAAKAGDVVMMLVPDELCADIYNTQVAPYM
                     TEGKALAFAHGFNIHFKTITAPKNVDVIMIAPKGPGHIVRRLYTEGEGCPSLICVEQDY
                     TGKAKDIALAYASGIGAGRAGILQTTFKEETETDLFGEQAVLCGGVCELIHAGFDTLVE
                     AGYEPEMAYFETCHEMKLIVDLINEGGFSKMRYSISNTAEYGDYRTGKRLITEETRKEM
                     KKVLTEIQDGTFASEFLTEMSPKGGRKVHFLAKRRMEAELPIEKVGAELRSMMSWLKK"
     CDS             complement(4936..5499)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_7"
                     /sec_met_domain="ALS_ss_C (E-value: 1.8e-28, bitscore:
                     88.6, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESDQRRVISLLVDNQSGVLARVSSLFCRRGFNIDSLTVSATNDP
                     AVSRITVTITSDEKALQQLVLQTERLEVTRQVFVLDSEKALERELLLLKVESDVHNRTE
                     LREIACIYKAKIIDLSPDSMVFELIGRPDKLDAFLKMFEGYNILEQCRTGVTALERGGM
                     HQHIQKPPQEVRSVQLPPPGARRA"
     CDS             complement(5515..7179)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.4e-51, bitscore:
                     163.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLNGSQIFVEVLCEQGVDTLFGYPGGAVLNLYDELYKNADRITH
                     VLTAHEQGAAHAADGYARATGRTGVVLATSGPGATNLVTGIATAYMDSVPMVAFTGNVP
                     TSSIGKDGFQEAYIEGITVPITKHNFTVRRVEDLADTMRAAFRIAQSGRKGPVLVDIPK
                     DVTAAVCEFTPKQPEPIRTVTTYNEEQVHWAADLINAAQRPLVYFGGGVRSAASCQPLR
                     DLLHKAEIPATYTLMAAGVVPYGDPMNLGMLGMHGCYTSNRAVAECDVLIAVGTRFSDR
                     VALNPKTFAKNATIIQIDIDASELGKNVDVDLSIVGDAAYVLNAMLPQIKPAKHPDWMT
                     MIQSWQAQDYHPVSDPTRLMPHQVIGEVCNQCGPDAVYVTDVGQHQMWAAQYLRHTKSR
                     GFITSGGLGTMGFGYGAAIGAQMALGRQQRVVMFTGDASFHMNLNEACTAVSYELPIIT
                     VIFNNSVLGMVRQWQTSFYGKRYSQTDPHRKTDFVKLADGFGLKGYRCTNLPEFQEAFA
                     DALQQKGPTWIECIIDKDEKVLPMIPGGGDINDIIME"
     CDS             7705..8922
                     /locus_tag="ctg90_9"
                     /transl_table=11
                     /translation="MKLREWNAHLHGLVVFRALLNDPVVAKLLDLTDRMEAGSTSYGPV
                     CDAVAAFEAALFEYTTNWGSYLSNAVLEAETICVRQAAAGQLDALLQSALDSELQFLQQ
                     LCGLTLDELFQTAYSEQAQRPELAFLPRWQTCELDLAAAYAQRMSEVGKKGYGMFAKHH
                     VFTVENGQLVPVKYPDPQRLSELPGYEKEREKVIANTKALLAGMPANNVLLYGDAGTGK
                     SSAVKAIANEFAPEGLRLVEVKKNQLYQIPDLMDKLAANPLKFILFIDDLSFTANDDNF
                     AALKAILEGSVGGRAQNIAVYATSNRRHLIKETLSDRTGDDIHEADTRQELMSLSARFG
                     LTVTFQRPEKARFETILEELAKQHNIQMPTEQLLLKAEAFALRAGGRSPRVAKQFIEQC
                     EAGVQK"
     CDS             complement(9010..9384)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Ribonuc_L-PSP"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1038:Endoribonuclease L-PSP (Score: 149.8; E-value:
                     1.2e-46)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg90_10"
                     /sec_met_domain="Ribonuc_L-PSP (E-value: 2.6e-47, bitscore:
                     149.8, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVVSTANAPAAIGPYSQALDLGNMVFVSGQLPVDPATGTMADTV
                     EQQAAQSLANLKAILAEAGLSMNNVVKTVIFLADINDFAAVNAEYAKAFAEPFPARSCV
                     QVAAIPKGAKLEIECIAVRD"
     CDS             complement(9572..10777)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_11"
                     /sec_met_domain="PALP (E-value: 4e-94, bitscore: 305.1,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTLDKIYHAAFVLKDVARKTDLIEAPKLSKDCQLYLKTENLQAT
                     GSFKVRGAYYKISQLSEEESAKGVIACSAGNHAQGVALAATRRGIRSIVCMPDGAPLMK
                     VENTKNLGAEVCLVPGTYDEAHDKAVQLQKEYDMTFIHPYDDEQVIAGQGTIGLEILDQ
                     LPDVDAVVVPVGGGGLISGIAFAIKTLRPEVKVYGVQAEGAPSMYRSLHEHKYQTLKSA
                     STFADGIQVKTPGELTYQLCEQYVDDIVTVTEDETAAAILSLMENQKLVAEGAGAVPVA
                     AVLFHKLPVEGKKVACVISGGNIDVNILNRVITRGLVMSGRKANLTIALEDKPGQLKKV
                     AEVVSRCGSNVVSVQHDGSDPNMPISSCFLKLTLETRDAAQIEQIRTELTKAGFQLVSE
                     RV"
     CDS             complement(10920..11822)
                     /locus_tag="ctg90_12"
                     /transl_table=11
                     /translation="MKNFAKRISALVLAVVLSAAVLCPAAFAAQLPSLPKDQCVVDGAG
                     VLSSSTVQTITELNAQLESSCSGAQIGVLTVEYTGNDSTEDYATQAFNAWGIGSSSNNN
                     GVLILLVMESAQYADGDYYLTYGDGFRNTTLAKQSSAIAQTMEDQFAAKNYDGAVTTCA
                     RNVANTIADIYGVSLSGGNGSTVQPGYQGGQSSGGSTLTDILTLVVSVVLLIVIIRSMA
                     YVFASPCGWLWCFGGPRPPRGRRRGPHNPPPPPGGFYGGFGGMGGGSFGGGAGRGSFGG
                     GFGGMGGGSSHGGGGGRGR"
     CDS             complement(11819..12577)
                     /locus_tag="ctg90_13"
                     /transl_table=11
                     /translation="MANADFSQNKQTAPGGFDAGSYREKAKPEQAVTLTPRQQKLAALE
                     AKLPAALSTRAAALALSVVVMLAAFFGFGSAKLRGKYNTARQWFTAGVAADNGYNLSEE
                     LTTRENTAANILTTASNTLGADSAEVLAAQTALNDFSACLQAVQNGGKSQSLTSLPYYQ
                     GSAMHALYQADQALGAAIDQLYAKLQEQAADPMKMGAVQGQYGQFNSAATIIGTLQYNT
                     AVYEYQKEVGGFPASVLGALSGVKEVEPFA"
     CDS             complement(12579..13652)
                     /locus_tag="ctg90_14"
                     /transl_table=11
                     /translation="VPQEEKPAAAPAPEAQVNLSPEEQAMVDQFAQKIDITNSQQVLQY
                     GSACQKKIGDFSEAALSKVSTKDLGEVGDMITNLIGELKSFDANEEQQKGIMGFFKKKT
                     SQLDALKTKYDKTETNVEKIQSMLEAHQVQLLKDIAMLDKMYELNMAYFKELSMYILAG
                     KKKLADVRANELQQAMDKAKVSGLPEDAQAARDLADQCERFEKKLYDLELTRNISLQMG
                     PQIRLLQNNNTMMAEKIQSTIVNTIPLWKNQMVLALGLAHSQQAMQAERAVTNMTNDLL
                     KKNAEALKLGTIETAKESQRGIVDIETLQQTNKSLIETLDELNKIQSEGRAKRAAAEQE
                     LTRIEDELKTKMMEIRS"
ORIGIN
        1 ccgaagaaga attttccaag ctgaaaaagc aagccgacca cggctatatg atggatgtgg
       61 agaaccgccg cttgaaagaa gaactttcca ccgccaagaa ggaagccatt cattggagca
      121 acaagtacca cgacctgtgg tacgatgtaa agccctatct ggacgcgctc caccgtgcgc
      181 ctgaactggt gcgcagcttt ttggaaaaga ttcttgcccc caagcaggag cgcaccatga
      241 atgtgccgca gaaaaaccgc aagcgtgggc aagatatgga actttgattt tcggaggata
      301 ctatttgaat aaaaagaaga agtcaaacaa atccggctac ccggatgaag ccatcaaaac
      361 ccttgcacgc tgcttttatc cctctatggt tgagtttttc aacagcgagg aaggccagcg
      421 tgaatatgag gagtggctga aagagcagga agctctacaa gccttgcctg ttgccgcata
      481 aaaacagcag gacgctccca gtaaagggac cgccctgcct tatatagatg tatctcaccg
      541 aggtgtgtcc agttgggcac acctcttatt tttttgccct caatcttcta gcccatggct
      601 cccggctgca tttttcaaat attcctccgg gtcaccgttc agaatcaaat ccgcatagcc
      661 aagcgggtca ttatagacga gatagtctaa ctccgacctc tgcgccatgg tcacgtccag
      721 tgcatcctca accccggtgc agtcaatgga aatttttctc ccatcttgga gagtcaactc
      781 cacacacccg gtatccatat tgaacaaaca ggctcttgca tcgtacttca taatcgcatc
      841 ctccaaattt tgttagtggc ttacggtcta tgacaaggta tcggagtttt gcgccgtcca
      901 cgggagcctt cattgttgta cccgaagaaa acgaaaaatc cgaacccttc tccaatcgga
      961 aacaggttcg gatttttctt gtttggtggg cgcgggtgga ttcgaaccac cgaagctgaa
     1021 aagcagcaga tttacagtct gtccccattg gccactcggg aacacgccca tattcagttg
     1081 ttgtgcatcc gtgcgccgga cgacttgttt attttagcat gagaaaaggg ttttgtcaac
     1141 cacctttttt cacttttttt cagcaggctt actgtccccc gcccgccgcg cttcatccgg
     1201 ttgaattgcg tcctgtttta tgttaaaata atgtaaagat tctacacatt ttacaggcag
     1261 gagtgggtca ttgcatggag tcaacaatca gcgccgcccc gcaaatttct atcgaccggg
     1321 aaaagacgct gcgcagctac cggcgttact gggtgctgcg gcgtgcacag gacatcgtat
     1381 tctccctgct ggcgctgatc ctgcttgcgc cgctggcact gctgatcagc cttgccatcg
     1441 tgctggacag ccccggagac ggagctattt tccggcagcg gcgggtagga cgggacggca
     1501 agctgttctg gctgtataag tttcgtacca tgtgcccgga cgccgaggag cagctgaatg
     1561 agctgctgag ccagaaccag atggacggcc cggtgttcaa gatcaagggc gacccccgca
     1621 ttacccgggt gggacgtttt ctgcgcaaga ccagtctgga cgagctgcca cagctgctca
     1681 acgtgctgca gggcgatatg agcatcgtgg ggccgcgccc cgcactgccc cgggaggtag
     1741 agctgtacag cgactaccag cgccagcggc tgtacgtcac ccccggactg agctgctact
     1801 ggcaaatcgc accccaccgt aacgagatga gctttgacga gtgggtggcg ctggatatga
     1861 aatacatcca ggagcgcagc ttctgggtgg actggaagat catcttcctc accgtccgcg
     1921 ccatgctcat gaaatacgga gagtgacaaa agcgcctgtt gtgcatccgc acaacaggcg
     1981 ctttcgttac gtttatttca gcactgcacc cagatttgca ctggtgacca tgcgggcgta
     2041 acggctcagc cagccggtct tgatgttggg ctcgggcgca acgtactttg ccttgcgctc
     2101 ggccagcact gcatcgctga cctccagcgt gatggaggcg ttggggatat caatggaaat
     2161 ggtatcccct tcctcgatca ggccgatagg gccgccggaa gctgcttccg ggctgacgtg
     2221 gccaatggca gcgccgcggg atgcaccgga gaagcggcca tccgtgataa gagcaaccgt
     2281 cttatccagc ttcatgcctg ccagcgcaga ggtggggttg agcatctccc gcatacccgg
     2341 gccgcccttg gggccttcgt agcggatgac caccacatcg cccgggacga tcttgcccgc
     2401 gtagatagcg gcaatggctt cctcttcgct gttgaacacc cgcgccgggc cggaatgctg
     2461 ctgcatctcc ggggcgacgg cgctgcgctt gacaacgcac ccgtccgggg caatgttgcc
     2521 ccacaggatc tgcagaccgc cggtctggga gtaggggttc tcgatgggac ggatggcctt
     2581 ttcgttcagg atatgggcac ccttgatgtt ctcgccaagg gtcttgccgg tgacggtggg
     2641 cacatccaga tccagcaagc ccttctttgc cagctctgcc tgcaccgccg ggatgccgcc
     2701 cgctgcgtac agatccggca tatgggtggg gcctgccggt gccaaatggc aaaggttggg
     2761 ggtcttggcg ctgatctcgt tgaacagctt caggtcgatg ggcacaccgg cctcgtaggc
     2821 gatagccagc aggtgcagca ccgtgttggt ggagcagccc agcgccatat cacaggtcag
     2881 cgcgttgcgg atggagcgct cgttgatgat ctggcgtgcg gtgatgccct tgcgcaccat
     2941 ctccatcaca gccataccgg cgtgctttgc cagctgcagg cgcttggagt acacagccgg
     3001 gatggtgccg ttgccgggca gggcgatgcc gatggcctcg cacaggcagt tcatgctgtt
     3061 ggcggtgtac atgccggagc agctgccgca gctggggcag cagttgcagg tgcagtcctc
     3121 cagctgctcg tcggtgatca taccggcctt ataagcaccc acggcctcga acattttgga
     3181 aaggctcact tcctcgccgc cgtaagtacc ggccagcata gggccgccgg agcagaccac
     3241 agcgggcaca tccatgcgca ccgctgccat taccatgccg ggcacgatct tatcgcagtt
     3301 gggcaccagc acaaggccgt ccagctggtg tgccatcagc atggtttcca cgctgtcgca
     3361 gatcagctcg cgggaggcca gagagtactt catgcccaca tgacccatgg cgatgccgtc
     3421 gcatacgccg atggcgggga tcaggatggg ggtaccaccg gccatctgca caccggcctt
     3481 gacggcatcg gcgatcttgt ccagattcat gtgcccgggc acgatctcgc tgtgggcgct
     3541 cactacgccg atgagcgggc gctccagctc ctccggggta tagcccagcg cataaaacag
     3601 gctgcggttg ggcgcgcgct ccgagccttt ggtcacgttg tcacttctca ttgcaaatcc
     3661 tcttttctga taaaaccctc tccgtcacgg ctgcgccgtg ccacctctcc cgagggggag
     3721 aggttttcgc ggagaagcta taaggctctc ttttcaacaa aagctccccc tttcggggga
     3781 gctgccgccg aaaggcggcc tgagagggtt ctcctcttac ttcttcagcc agctcatcat
     3841 gctgcgcagc tcagcaccca ccttctcgat gggcagctca gcctccatac ggcgcttggc
     3901 aaggaagtgc accttgcggc cgcccttggg gctcatctcg gtcaggaact cggaagcaaa
     3961 ggtgccgtcc tggatctcgg tcaggacctt cttcatctcc ttgcgggtct cctcggtgat
     4021 caggcgcttg ccggtgcggt aatcgccgta ctcagcggtg ttggagatgg agtagcgcat
     4081 cttggagaag ccgccctcgt tgatcaggtc aacgatcagc ttcatctcgt ggcaggtctc
     4141 aaagtatgcc atctcgggct cgtagccagc ctcaaccagc gtatcgaagc ctgcgtggat
     4201 cagctcgcag acaccgccgc acagaactgc ctgctcgccg aacaggtcgg tctcggtctc
     4261 ctccttgaag gtggtctgca ggatgcctgc acggcctgcg ccgatgccgg aagcataagc
     4321 cagagcgatg tccttggcct taccggtgta gtcctgctcc acgcagatca gagaggggca
     4381 gccctcgccc tcggtgtaca ggcggcggac gatgtggccg gggcccttgg gggcgatcat
     4441 gatgacgtcc acgttcttgg gagcggtgat ggtcttgaag tggatgttga agccgtgtgc
     4501 aaaggccagt gccttgccct cggtcatgta gggagccacc tgggtgttgt agatatcggc
     4561 gcacagctcg tcgggcacca gcatcataac aacgtcaccg gccttggcag cctcttccac
     4621 ttccatcacc ttgaagtttt cgtgggtggc agcgaactca gaagcctttg cccagtgggc
     4681 agagcccttg cgcaggccga ccacaacgtt gacgccgctc tcggccagat tctcagagtg
     4741 tgcatgaccc tggctgccga agccgatgac agcgacggtc ttgccgtcca gcacgccgag
     4801 gttgcagtcg gaatcgtagt atttcttgat agccataatc gttagtctcc ttttacatta
     4861 actggttggt ttatcttccg gtcttgtatg ctctgttcta tctttcgctc accctgagcg
     4921 gaaaagcaat gtgatttatg cccgtcttgc gcccggcggg ggcagctgga cggagcgcac
     4981 ctcctgcggc ggcttctgga tatgctggtg catcccgccg cgctccagtg cggtaacgcc
     5041 ggtgcggcac tgctcaagga tgttgtagcc ctcgaacatt ttcaaaaatg cgtccagctt
     5101 gtccggccga ccgatgagtt caaacaccat gctgtccggg gaaagatcaa tgatctttgc
     5161 cttgtagatg caggcgatct cccgcagctc ggtgcggttg tgcacgtccg attccacctt
     5221 gagcagcagc agctcccgct ccagcgcttt ttcgctgtcc agcacgaaca cctgccgggt
     5281 gacttccagc cgctcggtct gcaataccag ctgctgcaag gccttttcat cgctggtaat
     5341 ggtcaccgtg atgcggctga ctgccgggtc gttggtggcg gacaccgtaa ggctgtcgat
     5401 attgaagccg cggcggcaga acaggctgga cacccgggcc agaacgccgc tctggttgtc
     5461 caccagcagg ctgatgaccc tgcgctgatc agattccatg atgctgtgtc ctccttattc
     5521 catgatgatg tcgttgatat cgccgccgcc ggggatcatg ggcagcacct tttcgtcttt
     5581 gtcgatgatg cactcgatcc aggtggggcc tttctgctgc agggcatctg caaaggcttc
     5641 ctgaaactcc ggcagattgg tgcagcggta gcccttcagg ccaaagccgt ctgccagctt
     5701 gacaaaatcg gtcttgcggt gggggtcggt ctggctgtaa cgcttgccgt aaaagctggt
     5761 ctgccactgg cgtaccatgc ccagcaccga gttgttgaag atgaccgtga tgataggcag
     5821 ctcgtagctg acggcggtgc aggcttcgtt caggttcatg tggaaggagg cgtcaccggt
     5881 aaacatcacc acacgctgct ggcgtcccag tgccatctgg gcaccaatgg cggcaccgta
     5941 gccaaagccc atggtgccaa ggccgccgct ggtgataaag ccgcggctct tggtgtggcg
     6001 caggtactgc gccgcccaca tctggtgctg acccacatcg gtaacataca cggcgtcggg
     6061 gccgcactgg ttgcacacct cgccgatgac ctgatggggc atcagccggg tggggtcgga
     6121 cacagggtgg taatcctgtg cctgccagct ctggatcatc gtcatccagt ccgggtgctt
     6181 ggcgggcttg atctggggca gcatggcgtt cagcacatag gctgcatcgc ccacgatgga
     6241 aagatccaca tccacgttct tgcccagctc gctggcgtca atgtcgatct ggatgatggt
     6301 ggcgttcttg gcaaaggtct tggggttcag cgccacacgg tcggaaaagc gggtacccac
     6361 cgcgatgagc acatcgcact ctgccaccgc ccggttggag gtgtagcagc cgtgcattcc
     6421 cagcattccc agattcatcg ggtcgccata gggcacaacg cctgcggcca tcagggtgta
     6481 ggtggcgggg atctccgcct tgtgcagcag atcccgcaag ggctggcagc tggctgcgct
     6541 gcgcacgccg ccgccaaagt acaccagcgg acgctgtgcg gcgttgatga ggtctgccgc
     6601 ccagtgcacc tgctcctcat tataggtagt cacggtgcgg ataggctccg gctgcttggg
     6661 ggtgaactcg cacactgctg cagtcacgtc cttggggata tccaccagca ccgggccctt
     6721 gcggccgctc tgcgcaatgc ggaaggctgc ccgcatggtg tcagccaagt cctctacccg
     6781 gcgcaccgtg aagttatgct ttgtgatggg caccgtaatg ccctcgatgt aagcttcctg
     6841 aaagccgtcc ttgccgatgc tgctggtggg cacgttgccg gtaaaggcca ccatgggcac
     6901 cgagtccata taggcggtgg caatgccggt gaccagattg gtggcacccg ggccgctggt
     6961 agccagcacc acgccggtgc ggccggtggc gcgggcgtag ccgtccgcag catgggctgc
     7021 gccctgctcg tgggcggtaa gcacatgggt gatgcggtcg gcattcttat acagctcgtc
     7081 gtaaaggttc agcacagcgc cgccggggta gccaaaaaga gtgtccactc cctgctcgca
     7141 caggacctct acaaagatct gagaaccatt caactgcatg gtgttgctcc tattcctgtt
     7201 ccacttctta tccattcccc cggggagagc ttttgaaaaa gaaaaagccc ttgtcccctg
     7261 ctttcttcaa gagacaaaga ccttgtaaca tcaagctctc tgcggtacca ctctcgttgg
     7321 cgtgctgtgc acaccctctc acgggcttcc aacaaagccc tgcacggtaa cggctgcaac
     7381 cggcgctgct tacaggggtt tgcacccgtt gggcaggctg ctccgggatg attttccgca
     7441 cgaaacgctg actgccttgc accagacggc agctctctga acagtgggga tcgtgtggta
     7501 ctttttccca tctgcgcatt tgttgatgta aattatacta taaaccgggc ttttgtcaat
     7561 cgacaatttg taacctgaat caccccaaag atgaagcatt tttaacaccc cttgcatccc
     7621 cgcccgaacc gctgtatact tttgatatcc gcgtacctgc gttttgtagg gtatgtgcca
     7681 atggagagga aaagggatcg acctatgaaa ctgagagaat ggaatgccca tctgcatggg
     7741 cttgttgtgt tccgcgccct gctgaacgac cctgttgtgg caaagctttt agacctgacc
     7801 gaccgcatgg aagccggcag cacctcctac ggcccggtgt gcgatgccgt agccgccttt
     7861 gaggccgctt tgttcgagta caccaccaac tggggcagct acctgagcaa tgctgtgctg
     7921 gaggccgaga ccatctgcgt gcggcaggcc gccgccgggc agctggacgc gctgctgcaa
     7981 agcgccttgg acagcgagct gcagtttttg cagcagctgt gcgggctgac gctggacgag
     8041 ctgtttcaga ccgcctactc ggagcaggcg cagcggccgg agttggcgtt cctgccccgg
     8101 tggcagacct gtgagcttga ccttgccgcc gcctacgccc agcgcatgag cgaggtgggc
     8161 aaaaagggct acggtatgtt tgcaaagcac catgtattca cggtggagaa cggccagctt
     8221 gtgccggtaa aataccccga cccgcagcgc ctttccgagc tgccaggcta cgagaaggag
     8281 cgggaaaagg tgatcgccaa cacaaaggca ctgctagccg ggatgcccgc caacaatgtg
     8341 ctgctgtacg gtgacgccgg taccggcaaa tccagcgcgg taaaggccat tgccaacgag
     8401 tttgcgcccg agggactgcg gctggtagag gtaaaaaaga accagctgta ccagatcccc
     8461 gacctgatgg ataagctggc ggcaaacccg ctcaagttca ttttgttcat cgacgacctg
     8521 agctttaccg ccaacgacga caactttgcc gccctgaagg ccattttgga gggcagcgta
     8581 ggcggccgtg cccagaacat tgcggtgtac gccacctcca accgccgcca cctcatcaag
     8641 gagactctct cagaccgcac cggcgacgac atccacgaag ccgacacccg gcaggagctg
     8701 atgagccttt ccgcccggtt cggcctgacg gtcaccttcc agcggccgga aaaggcacgg
     8761 ttcgagacca ttctggagga gctggcaaag cagcacaaca tccagatgcc caccgagcag
     8821 ctgctgctca aggccgaggc ctttgccctg cgtgccggcg gccgcagccc ccgggtggcc
     8881 aagcagttca tcgagcaatg cgaggccggg gtgcagaagt aaatgcacca gttttaagcg
     8941 ttatcaaaaa acgggacacc aaagcatccg cagatgcttc ggcgtcccgt ttttcctatc
     9001 tttattcgct cagtcccgca cggcgatgca ctcaatctcc agctttgcgc ccttggggat
     9061 ggctgccacc tgcacgcagc tgcgggcggg gaacggctcg gcaaaggcct tggcgtactc
     9121 tgcgttcact gcggcaaaat cgttgatgtc ggccagaaag atcaccgtct tgaccacgtt
     9181 gttcatggaa agccccgcct cggccagaat cgctttcagg ttggcaaggc tctgtgcggc
     9241 ctgctgctcc acggtatcgg ccatggtgcc ggtggcgggg tctaccggga gctgcccgga
     9301 aacaaacacc atattgccca gatccagtgc ctgactgtaa gggccgatgg cggcaggtgc
     9361 gttggcggta gatacgactt tcatggtata ttttctcctt tatattacat caggtttaga
     9421 acaaattcgc ttttttcttc ggatagagcc agatgagggg gtaatttccc gtaagccgct
     9481 gcttgcctgt gccctcatcc gtctgctcac tccgttcgca tccaccttcc cccgtccggg
     9541 ggaaggtttt cactcttgca aacgatgaag tttacacccg ctcgctgacc agctggaaac
     9601 cggccttcgt cagctctgtg cggatctgct cgatctgggc ggcatcgcgg gtctccagcg
     9661 tcagcttgag gaagcagctg gaaatgggca tattggggtc ggagccatcg tgctgcaccg
     9721 acaccacgtt gctgccgcag cgggacacca cctcggccac ctttttcagc tggccgggtt
     9781 tgtcctccag tgcgatggtc agatttgcct tgcggccgct catcacaagg ccgcgggtga
     9841 taacgcggtt caggatattc acatcaatgt tgccgccgga gatgacgcag gccacctttt
     9901 tgccctctac cggcagcttg tggaacagca ccgccgccac cggcacagcg cctgcaccct
     9961 cggccaccag cttctggttc tccatcaggg agaggatggc cgccgccgtc tcgtcctcgg
    10021 tcacggtgac gatatcgtcc acatactgct cgcacagctg gtaggtcagc tcgcccgggg
    10081 tcttgacctg aatgccgtcc gcaaaggtgg aagcagattt cagggtctgg tacttgtgct
    10141 cgtgcaggct gcggtacata ctgggggcac cctcggcctg tacgccgtac accttgacct
    10201 ccgggcgcag ggtcttgatg gcaaaggcaa tgccggagat cagtccgccg ccgcccaccg
    10261 gcaccaccac agcgtccaca tccggcagct ggtcaaggat ctccaagccg atggtaccct
    10321 gcccggcgat gacctgctcg tcatcgtagg ggtggataaa ggtcatgtcg tactcctttt
    10381 gcagctgcac ggccttgtcg tgggcttcgt cgtaggtgcc gggcacaagg cagacctccg
    10441 cgcccagatt tttggtgttt tccaccttca tcaggggtgc gccgtccggc atacagacga
    10501 tgctgcggat gccgcgccgg gtagccgcca gcgccacacc ctgcgcatgg ttgcccgcag
    10561 agcaggcaat gacgcccttg gcgctctcct cctcggaaag ctggctgatt ttatagtaag
    10621 cgccccgcac cttaaagctg ccggtggcct gcaggttctc ggtcttaagg tacagctggc
    10681 agtccttgga cagcttgggg gcttcgatga ggtcggtctt gcgcgctacg tccttcagca
    10741 caaaggcggc gtggtagatc ttatccagag tcagcatgac agatacttcc tttatttttc
    10801 gtgatgtcat ccagtataag ttacaaaaat tgttttgtca aatgaattcc attcacgata
    10861 aaaggcgtaa aaaagagaaa ggcagtggta aagccaccgc ctttctcttt ttattctcat
    10921 taccgcccac ggccaccgcc gccgccatgg ctggaaccac cgcccatgcc accgaagccg
    10981 ccgccaaagc tgccgcgccc ggcacctccc ccgaaggagc cgccgcccat gccgccaaag
    11041 ccgccgtaga agccgcccgg cgggggcggc gggttatgcg ggccgcgccg ccgtccacgg
    11101 ggaggccgcg gcccaccgaa gcaccacagc cagccgcagg ggctggcaaa aacataggcc
    11161 atcgaccgga taatgacgat gagcagcaca acgctgacca caagggtcag gatgtcggtc
    11221 agggtgctgc cgccgctgct ctgcccgccc tgatagccgg gctgcacggt gctgccgttg
    11281 ccgccggaaa ggctgactcc gtaaatatcc gcgatggtgt ttgccacgtt gcgggcacag
    11341 gtggtcaccg cgccgtcata attctttgcg gcgaactggt cttccatggt ctgggcgatg
    11401 gcgctggact gctttgccag cgtggtgttg cggaagccgt cgccataggt caggtagtag
    11461 tcgccgtccg catactgtgc cgactccatc acaagcagga tcagaacacc gttattgttg
    11521 gaggacgaac cgatacccca ggcgttgaaa gcctgtgtgg cgtaatcctc tgtggaatca
    11581 ttgcctgtgt attctactgt cagtacaccg atttgcgcgc cgctgcagct ggattccaac
    11641 tgggcgttca gttcggtgat ggtctgcacg gtgctgctgc tcagcacacc agcaccatcc
    11701 accacgcact gatctttggg caggctgggc agctgggcgg caaaggccgc cgggcacagc
    11761 accgccgcgc tgagcaccac ggccagcacc agtgcgctga tacgttttgc aaagtttttc
    11821 atgcgaaggg ttcaacctcc ttcacgccgg acaaagcgcc cagcacactg gccgggaagc
    11881 cgccgacttc cttctgatat tcatacaccg ccgtattgta ctgcaaagta ccaatgatgg
    11941 tggctgcgct gttgaactga ccgtactgcc cctgcaccgc gcccatcttc atggggtcgg
    12001 cggcctgctc ctgcaacttt gcatacagct ggtcgatggc agcgcccagt gcctgatcgg
    12061 cctgatacag cgcgtgcatc gcgctgccct gataataggg cagcgaggtc agcgactggc
    12121 ttttaccgcc gttctgcacc gcctgcagac aagcggagaa atcgttcagc gccgtctgtg
    12181 cagccagcac ctcggcgctg tctgcgccaa gggtgttgga ggcagtggtc agaatattcg
    12241 ccgccgtatt ctcccgggtg gtcagctcct cgctcaggtt ataaccgttg tcggcggcga
    12301 cccctgcggt gaaccactga cgggcagtgt tgtacttgcc gcgcagcttg gcgctgccaa
    12361 agccgaaaaa ggcggccagc atcaccacta cgctcaaggc cagcgccgcc gcccgggtgg
    12421 aaagcgcagc gggcagcttt gcttccagtg cggccagctt ctgctggcgc ggggtcagcg
    12481 ttacggcctg ctccggcttt gctttttcgc ggtagctgcc cgcgtcaaag ccgccgggag
    12541 cggtttgttt gttctgagaa aaatcagcgt ttgccatttc agctccggat ctccatcatt
    12601 ttggttttca gttcgtcctc gatgcgggtc agctcctgct cggcggcggc gcgctttgcg
    12661 cggccctcgc tctggatctt gttcagttcg tccagcgtct cgattaggct cttgttggtc
    12721 tgctgtagcg tctcgatatc cacgatgccg cgctggctct ccttggcagt ctcaatggtg
    12781 cccagcttca gcgcctcggc gttcttcttc agcaggtcgt tggtcatgtt ggtcacggcg
    12841 cgctcggcct gcatggcctg ctggctgtgt gccagcccca gtgccagcac catctggttc
    12901 ttccacagcg ggatggtgtt cacgatggtg gactggatct tttccgccat catggtgttg
    12961 ttgttctgca gcagacggat ctgtgggccc atctgcaaac tgatgttgcg ggtcagctcc
    13021 agatcataca gctttttctc aaagcgctcg cactggtcgg caaggtcgcg ggcggcctgt
    13081 gcatcctccg gcagaccgga gaccttggcc ttgtccatag cctgctgcaa ttcgttggca
    13141 cgcacatcag ccagcttttt cttgccggca aggatataca tgctcagttc cttgaagtag
    13201 gccatgttca gctcgtacat cttgtccagc atagcgatat ccttgagcag ctgcacctga
    13261 tgggcttcca gcatggactg gatcttttcc acgttggtct cggtcttgtc gtacttggtc
    13321 ttgagggcat ccagctggct ggttttcttc ttgaagaagc ccataatgcc cttctgctgc
    13381 tcctcgttgg catcaaagct cttcagctcg ccaatgaggt tggtgatcat atcgcccacc
    13441 tcgcccagat ccttggtgga caccttggag agggctgctt cggagaaatc gccgatcttc
    13501 ttctggcagg cagagccgta ctgcagcacc tgctggctgt tggtgatatc gatcttctgg
    13561 gcaaactgat ccaccatggc ctgctcctcg gggctcaggt tcacctgtgc ctccggggca
    13621 ggggcagcgg cgggcttttc ctcctgcggc ac
//
