LOCUS       c00052_gnlPro..        14777 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ENJKBHIJ_52.
ACCESSION   c00052_gnlPro..
VERSION     c00052_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 01:30:12
            Original ID  :: gnl|Prokka|ENJKBHIJ_52
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 54485
            Orig. end    :: 69262
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14777
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[64485:67713]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14777
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14777
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(521..2260)
                     /locus_tag="ctg52_46"
                     /transl_table=11
                     /translation="MALDGIFLRHIKSEIEKEALGARVSQIYQPNREELVFGLRTFSGN
                     KKLLLSARANSPRVNFCSSTPENPAQPPMFCMLLRKRIGGGKLVGLRQNGCDRVLMLDF
                     ECVNELGDTVMITVVCEIMGMYSNIIIVDSNGVIIDSLKRVDLTMSSKRLVLPNIKYEL
                     PESQNKLNLLKCSVLDVCTAVKNLDTEMPLNKALLRTIEGVSPIVCREIEYKVMEGATN
                     RIEGVLFDRLAVEIEKLKSVCSDCSGKPVVVYREDGKPMDFCFMNVEQYGDFAKVESKE
                     SFSDLLDGFYEARDSRDRMRVKSQSLTKLLNNTLERLARKIAKQKSELERCADREHLRI
                     CGDLLQANIYRIERGAEYVDVENFYDENNAILRIKLNPAISPSANAQKYYKDYRKAKNA
                     EIMLKEQLEKGREELDYINSVLDTVDRAENEKDLVQIREELTEQGYLKVQKGKKPRQTT
                     LPPLEFESSDGFKILVGRNNRQNDKLTLKTASKNDMWLHTKDIHGSHVIVVSDGKEISD
                     TAIYEAARLAAYHSKARNSSQVPVDCTLVRYVSKPNGSKPGMVIYVNNKTLYVKPSQTV
                     EKQ"
     CDS             complement(2275..2760)
                     /locus_tag="ctg52_47"
                     /transl_table=11
                     /translation="MIKINIICIGKIKEKYFTDAIAEYAKRLTAFCKFNIIELSEERIK
                     SNIPNRSQIDEVIFSEGKRIMQKISPSDYVVAMCIEGKSMSSEELSKLIDNASVSGKST
                     VDFIIGGSYGLDESVKKRADVRLSMSRMTFPHQMARMILSEQIYRAFEISSNGKYHK"
     CDS             complement(2782..3570)
                     /locus_tag="ctg52_48"
                     /transl_table=11
                     /translation="LARAVPLFSGSKGNSYYIGSASEGVLIDAGRSCKQIENAMLANGL
                     DMGSIGAVFITHEHTDHCSALRVLAKRYGFKVYSSLGTLNALRAGNKLDPNTDADVITD
                     EVVIGNMRVQRIDTPHDAAESCCYRVTAPDGKSALIATDMGVMLPDVRTAAEQSDFVVL
                     ESNHDINMLKNGFYPYPLKQRILSNRGHLSNEACAKELVNLVEKGTLRLMLGHLSEENN
                     TVPLAMSTSVDLLTSNGMKYKSDYSLDVAPSVSTTKAIIF"
     CDS             complement(3693..4985)
                     /locus_tag="ctg52_49"
                     /transl_table=11
                     /translation="LEKFVVTGGKPLSGEVTISGAKNAAVAIIPAVILCDEPCQIENIP
                     NISDVSLISRILQQMGANVRRINRSSLYIDPTKIRTCNAVTDLVRGMRASYYLLGALLG
                     KYGKAKVALPGGCNFGVRPIDQHLKGFEALGATTQLVDGAIIEAECDSLVGTHVYLDVV
                     SVGATMNIMLAASKAKGQTIIENAAREPHIVDLANFLNSMGADVRGAGTDVIKIRGVEY
                     LHGITYSIIPDQIEAGTYMCAAAATRGCITVKNITPKHLESISAKLREMGVKITEYDEA
                     LKVDASSAPLKRCNIKTMPHPGFPTDCQPQFAALLMSVPGTSIINENVWDNRYQYVSEL
                     IRMGAQISVEGRLAIIEGGVPLTAAPVKATDLRAGAAMIIAALEINGTTEISNIQFIER
                     GYEDVVEKFRGLGADIKKVYFTGDNEQELGA"
     CDS             5716..6033
                     /locus_tag="ctg52_50"
                     /transl_table=11
                     /translation="MENKEKTTTPEMPDIDVLFELADLFKVFGDSTRLRIMYTISENEM
                     SVLNIAEALSMEQSTISHQLRVLRQNKLVRVRREGKQIYYSLDDDHVKRIIEMGLDHVL
                     E"
     CDS             6046..8370
                     /locus_tag="ctg52_51"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCAHCAGKIEAKIAETDGFEDVSFNFATKLLNFKS
                     EKQNPVSEIQAICDSIEDGVTVVDKTPKTNLKKYTYILDNLNCAHCAGKIEAKIAETDG
                     FEDVSFNFATKLLNFKSEKQNPVSEIQAICDSIEDGVTVVDKTPKNDITTKAEPEITKK
                     KISHDTIFLAISIVLAVVSEIFHLTLDGVTAVHYVVLAACFVATLLSGYKVFIKGAKNI
                     LKLRIDETTLMSVAVIAAFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIR
                     PDTATIIVDGAEQIVPAESVEIGSIIEVKPYERVPLDGIIIKGKTTLDTSALTGESLPV
                     DAGEGSEVLSGAINGSNLITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISRFASV
                     YTPVVVLIAVAIAVIPPLCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAAS
                     EVGVLIKGGKYIEALAKADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEK
                     YSAHPIASAIREKANGLKLPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEQKKIAN
                     KDDSVFVIYDGQLIGSLNVSDTVRPEAKEVISQLKALGVKNTVMLTGDRQQPAENVKNE
                     LGLSECHAELLPAQKLELFKGLKSKSKGACFVGDGINDAPVLSASDCGIAMGFGSEAAI
                     EASDAVLASGTLKQLPKAIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVI
                     ADTGVSVVCVIIAARLLKKKY"
     CDS             8737..9804
                     /locus_tag="ctg52_52"
                     /transl_table=11
                     /translation="LEIYYNDKKIDNLNLFDAFMPTEDGLIYSKINETSPNEIEYYRYY
                     LDKKSSIKLGSIKDWTMQINDKAYVNNHLCFMASTGDITDEENRTLEFIDIDLNKNKMT
                     TVFSDKGGFPYDTVTGADNLVIITKVLNNGTSLELYDTETQKFKQLKYLEFDDKNCVGK
                     TIRKVSIDDKTKTICLLVLDCVSETDVSLKIETYDYDMNFLKSYDISNISDDSNELIQG
                     VQFFDFRNNYLIYQNFSITRCIGYIGNKKLQKSDMIDNIDDTYSMAQTPQKGYNTVLSF
                     KDVDLERNIYLFNTIDKTMKKTKFKPEEENYYIGSMSRTGKDNLMIITTPDNADKKSNL
                     NPKLYFTKLSDLKFQ"
     CDS             10001..11623
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_53"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-42, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             11636..12127
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_54"
                     /sec_met_domain="ALS_ss_C (E-value: 7.6e-30, bitscore:
                     94.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRINTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             12188..13228
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_55"
                     /sec_met_domain="IlvN (E-value: 3.4e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.4e-60, bitscore: 194.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKIAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(13521..14777)
                     /locus_tag="ctg52_56"
                     /transl_table=11
                     /translation="YTVRCITSDAKKFTSGYNPTGKSVKYVATPKISKLEVTYDGVKLT
                     WNKVAGAEKYRVYYKDRNGWTKLADTTGTTMLDMNVVSKEFDLSIDDIYYTVRCISKDA
                     KSFTSGYDSKGTPIGNHQDCPEIYSIGAVNNGIEMHWTGDAPKFRVYIKENGFWKRIAE
                     TYDNYYVHKGAKSGSNTYTVRGVSKDGKKFTTMFNPTGVTYRYKTSDKTRDAYINYMMN
                     HQSEWMPSLGSNHNLSGVMFLDFDFDGVPELVAQKADSNEYSFHSVVYKFEDGKLKRVG
                     NVNDGFAIYYNKTAKKYEVHDLKISLNVDDGYYWSGNSIITYDGENLFANMYSARGVGE
                     ESNNNIYYRYFDGNDKNISRAKYNEINLKQFNNCVNAHMFTKFIVTGYGDTSVWGEKTT
                     AENKQSLLDAYNSFSYEKY"
ORIGIN
        1 agattcggcg atcaggtttt gttaagtctt atgtgtcagt acattcctat gggcaaggtc
       61 agcgacaggg agttttcacg aattaaccgt aaaatcacac gcagagaata tgacaaggta
      121 aagcttgaaa tgatgcgact gggaattgac ggctttacac aggagctttc ttccgcagat
      181 gaaagctatg tccccgaatg ggattttgaa ggatgatttt gttcggtcat ctgaattcct
      241 cttcattttt caattggtat tgtttacttg gtattattct cttagtcttt ttctatgggt
      301 attattaggc ttcaaattct gaagtagtcc ccttcaaaat ctgaagggga cgggttcaaa
      361 ttctgaaggg ggcaggtgca aattttgaag ggtatgagtt caaattctgc acccctaaaa
      421 tacgaatttt tacattcgat tttaccgccc gttaaaaaca attaaattaa cataaaaacg
      481 gagagcgtct tgccctccgt ttaattttta ttaaaatatc ttactgcttt tcaaccgttt
      541 gtgacggttt tacatacagg gttttgttgt tgacataaat caccataccc ggttttgagc
      601 cgtttggctt tgacacatag cgaacaagtg tgcagtcaac aggaacctga ctgctgtttc
      661 tcgccttact gtgatatgcc gcaagccgtg ccgcctcgta gattgccgtg tcggaaatct
      721 ctttgccgtc cgaaacaaca attacatgag aaccgtgaat gtcctttgtg tgcagccaca
      781 tatcgttctt tgatgctgtt ttcaaagtca gcttatcatt ctgacggttg tttcttccta
      841 caaggatttt aaaaccgtcg cttgattcaa attcgagtgg cggcaaagtt gtctgacggg
      901 gctttttgcc cttttgaacc ttgagatagc cctgctcggt aagttcctca cgaatttgta
      961 caaggtcttt ttcattttcc gcacggtcaa ccgtatcgag aaccgagtta atataatcaa
     1021 gctcttccct gcccttttca agctgttctt tgagcataat ttcggcattt ttagccttgc
     1081 ggtaatcctt gtaatacttc tgagcatttg ccgaaggtga gattgccgga ttaagcttta
     1141 tgcgtaaaat tgcgttgttc tcatcgtaaa agttttcaac atcaacatac tccgcaccac
     1201 gctcaatgcg atagatattt gcctgtaaaa ggtcaccgca tatgcgaaga tgctcacggt
     1261 ctgcacagcg ttcaagctca ctcttctgct ttgcaatttt tcgtgcaagc ctttcaagtg
     1321 tgttgttcaa aagctttgta aggctttgtg atttcaccct cattctgtca cgactgtcac
     1381 gagcctcata gaatccgtca agcaaatcgg agaagctttc cttactctca acctttgcaa
     1441 aatcgccgta ctgctcaaca ttcataaagc agaagtccat aggcttgccg tcctcacgat
     1501 aaaccacaac aggcttgccc gaacaatcgc tgcaaacgct tttcagcttt tcaatttcaa
     1561 ctgcgagtcg gtcaaaaagc acaccctcaa ttctgtttgt tgcgccctcc ataaccttgt
     1621 attcaatctc acggcataca atcggagaaa caccctcaat tgtccttaac agcgccttgt
     1681 taagcggcat ttccgtgtca agatttttta cggctgtaca cacatcaagc accgaacatt
     1741 taagcagatt cagcttgttc tgcgattcgg gaagttcgta ttttatattc ggcagtacaa
     1801 gtcttttact gctcattgta agatctacac gcttgagtga atcgatgatg acgccgtttg
     1861 aatcgacaat aattatgttg ctgtacatac ccataatttc gcatacaaca gttatcatca
     1921 cagtatcgcc gagttcgttc acgcactcga aatcgagcat aagaacacgg tcacaaccgt
     1981 tctggcgaag tcccacaagc tttccgccgc cgattctttt tcgcaaaagc atacagaaca
     2041 tcggaggttg tgcaggattt tcgggtgttg acgaacagaa gttcactctc ggtgaatttg
     2101 ctcgtgcaga aagcaacagc tttttgttgc cggaaaatgt tctcagcccg aacacaagct
     2161 cctctctgtt cggctgataa atctgcgaca cccttgcacc gagagcctct ttttctattt
     2221 cacttttaat atgtcttaaa aaaattccgt caagcgccat agtaactccg taaattattt
     2281 gtgatattta ccgtttgatg aaatctcaaa cgcacggtaa atctgttcgc ttaaaatcat
     2341 tcttgccatt tggtgaggaa aggtcattct gctcattgaa agacggacat ccgcccgttt
     2401 tttaaccgat tcgtcaagtc cgtagctgcc gccgataata aaatcaacgg tgctttttcc
     2461 gcttacggac gcattgtcaa tcagctttga aagctcctca ctcgacatag actttccctc
     2521 aatacacatt gcaacaacat aatccgaagg cgaaattttc tgcatgattc gttttccctc
     2581 agagaaaata acctcatcaa tctgcgacct attcggtatg ttgctcttaa tgcgttcttc
     2641 cgaaagctca ataatattga atttacaaaa tgcggtcaag cgttttgcat actctgcaat
     2701 tgcgtcggta aaatattttt ccttgatttt gccgatacaa attatgttaa tcttaatcat
     2761 attcctcttg tttgtttaag gttaaaagat gatggctttt gttgtgctta cactcggagc
     2821 aacatcaagc gaataatcgc ttttgtactt cattccgttt gatgtgagca ggtctacgga
     2881 tgttgacatt gcaagcggaa cggtattatt ttcttcgctg agatggccga gcataagtct
     2941 taaagttccc ttttcaacaa ggttaacaag ttcttttgca catgcctcat ttgaaagatg
     3001 tcctctgttt gaaaggattc tctgctttaa cggataagga taaaatccgt ttttgagcat
     3061 attgatatcg tgatttgact caagcacaac aaagtcgctc tgctctgcgg cagttctgac
     3121 atcgggcaac ataacgccca tatcggttgc tataagtgcg gattttccgt cgggagcagt
     3181 aacacggtaa caacagcttt ccgccgcatc gtggggggtg tcaattcgct gaacacgcat
     3241 attgccgatt acaacctcgt cagttataac atctgcatcc gtgtttggat caagcttatt
     3301 acctgccctc aaagcattga gcgtaccaag acttgaatac accttaaagc cgtaacgctt
     3361 tgcaagcaca cgcaacgcac tgcaatggtc agtgtgttcg tgagttataa aaaccgcccc
     3421 gatactgccc atatcaagtc cgtttgcaag catggcattt tcaatctgct tgcatgaacg
     3481 acctgcgtca atcagtacgc cttcgcttgc cgaacctatg tagtagctgt tacccttact
     3541 tccgctgaac agcggtactg ctcttgccaa aacaatcaat ccttatcttt agtgtaacga
     3601 atatgataac acaaatttta aaatttgtaa attatctcac aaaaaagccg ttctcacaaa
     3661 gaaaacggct ttgatttcta attaaatttt agtcaggcac cgagctcttg ctcgttgtct
     3721 cctgtgaaat acaccttttt gatatctgca ccaagtcctc tgaacttttc aacaacatct
     3781 tcatatccac gctcaatgaa ctgaatattt gaaatctctg ttgtaccgtt aatttcaaga
     3841 gcggcaataa tcatagccgc acctgcacga aggtcggttg ccttaacggg agccgctgtg
     3901 agcggaacac cgccttcaat gattgcaagt ctaccctcaa cagaaatctg cgcacccatt
     3961 ctgataagct cgctgacata ctgatagcga ttatcccaaa cattctcgtt gatgatgctt
     4021 gttccgggaa cgctcataag caatgcggca aactgcggct gacagtctgt cggaaagccg
     4081 ggatgcggca ttgtcttgat attacagcgc tttagcggag cagatgacgc atcaaccttg
     4141 agagcctcat catattccgt aatcttaaca cccatctcac gcagctttgc actgattgat
     4201 tcaagatgct tcggtgtaat attctttacc gtaatacaac ctcttgttgc ggcggcggca
     4261 cacatatatg ttcctgcctc aatctggtcg ggaataatcg aataagtaat gccgtgaaga
     4321 tactcaacgc cacggatttt gataacatcc gtacctgcgc ctctgacatc cgcacccatt
     4381 gaattaagga agttcgcaag gtcaacaata tgcggttctc ttgcggcatt ttcaataatg
     4441 gtctgtccct ttgcctttga tgcggcaagc ataatgttca ttgttgcacc aacggacaca
     4501 acatcaaggt acacatgtgt accgacaagg ctgtcgcatt ctgcctctat aattgcaccg
     4561 tcaacaagct gagttgtcgc accgagagcc tcaaagcctt taagatgttg gtcaatcgga
     4621 cgcacgccaa agttacagcc gcccggaaga gccaccttag ccttgccgta cttgcccaaa
     4681 agtgcgccga gaagataata tgacgctctc atacctctta caaggtcggt cacagcattg
     4741 catgtgcgga tttttgtagg atcaatatat aaggacgaac ggttgattcg tcttacatta
     4801 gcacccatct gctgaagaat tctgctgata agtgatacat cgctgatgtt aggaatattt
     4861 tcaatctggc atggctcatc acaaagaata actgccggaa taattgcaac ggctgcattt
     4921 ttcgcaccgc tgattgtcac ttcacccgat aatggctttc cgccggtaac tacgaacttc
     4981 tccaattgtt acaccccaat taatgtgtag aagatacttt taactaaata agctaaatat
     5041 ctgaaaatgt atatctatat agtgtataag taaaaatcaa aaattatacg aatctaaaat
     5101 tcataatgag aactaatttg ttacatttta ttaaaaacga acccactcgg ttacgcagat
     5161 gtaatttaac aattctctta cagaaaatga tactacaaaa ttgtagtaaa gtcaacggaa
     5221 taataaaact gtaatctatt tttgggcaag ttgtactcaa attattaatt tgttgctttt
     5281 tttgttttta atataaccaa ccatgctttt taaaaccgtt ttttcctaaa aagaagtaat
     5341 taatcaaagc gattttttgt aaaattatta caaattgaaa caagtgttat tttcgtgtta
     5401 tcatcaggca tctgagtatt ttccaattca aattgaacac agaaaaatat cgttccgtta
     5461 ctcctatgat aattttacac cttcaatctt cttttttcaa atttaaaatt aactttctat
     5521 actatatata ctttccaaac ggacacaata aacaagtgaa actttggggc aaaaaaactt
     5581 gaaaaacatt acattttttc gtgtgtgtct attgactttt taaaaaggga atgctatatt
     5641 ataattaaca tatgagcata tcttcatatg ttcaagtata actattaacc tgagagaaaa
     5701 ttaaagggga cgcctatgga aaacaaagaa aaaacaacca ctcccgaaat gcccgacatt
     5761 gatgtgctgt ttgagcttgc agaccttttt aaggttttcg gtgattcaac ccgacttcgc
     5821 attatgtaca ccatttcgga aaatgaaatg tcggtgctca acattgctga agctctcagc
     5881 atggagcaaa gcacaatttc ccaccaactg cgtgtgttaa ggcagaacaa gctggtgcgt
     5941 gttcgccgtg aaggaaagca gatttattac agccttgacg atgaccatgt gaaacgaatc
     6001 atagaaatgg gacttgacca tgttcttgaa taaggaggga gacatatgag gtacaaatat
     6061 cagcttgaca atctcaactg cgctcattgt gcgggcaaaa ttgaggctaa aattgcagaa
     6121 acagacggct ttgaggatgt aagctttaat tttgcgacaa aacttctcaa cttcaaaagc
     6181 gaaaagcaga atcctgtttc cgaaattcag gcaatctgcg acagcattga ggacggcgta
     6241 accgttgttg acaaaactcc gaaaaccaat ctcaaaaaat acacctacat tttagacaat
     6301 ctcaactgcg ctcattgtgc gggcaaaatt gaggctaaaa ttgcagaaac agacggcttt
     6361 gaggatgtaa gctttaattt tgcgacaaaa cttctcaact tcaaaagcga aaagcagaat
     6421 cctgtttccg aaattcaggc aatctgcgac agcattgagg acggtgtaac tgttgttgac
     6481 aaaactccta aaaatgatat cacaacaaag gcagaacccg aaatcacaaa aaagaaaata
     6541 agccatgaca caatcttcct tgcaatttca attgtacttg ctgtagtgtc cgaaattttc
     6601 caccttacac ttgacggtgt tacggctgtt cattatgttg tactcgcagc gtgttttgtt
     6661 gcaacacttc tttcgggtta caaggtattc atcaagggtg caaaaaacat tctaaagctg
     6721 agaattgacg aaacaacgct tatgtctgtt gcggtaattg cggcattctg tcttggagat
     6781 tttgttgagg cggcaatggt aacaatcctc ttttctatcg gtgaaatttt tgaggatcga
     6841 gcagttgacg catcccgccg tgacattgaa aagcttgcaa acattcgtcc cgatacagca
     6901 acaattattg ttgacggtgc ggaacagatt gttcctgccg aaagcgttga aatcggaagt
     6961 atcattgaag tcaagccata cgaaagagtt ccgcttgacg gcattattat caaaggtaaa
     7021 acaactctcg acacatcggc tctcacaggc gaaagccttc ctgttgatgc aggcgagggc
     7081 agtgaggtac tcagcggcgc aatcaacggc agtaacctta ttactgtcaa aaccacaaaa
     7141 catttcggcg acagtaccgc aacaaggatt cttcagcttg ttgaagatgc cgccgctcaa
     7201 aagggcaaca gcgaaaagct tatttcaaga tttgcctctg tttacacacc ggttgttgta
     7261 ctcattgcag ttgcaatcgc agtaattcct ccgctttgcg gactcggagc attcagcgaa
     7321 tggctctacc gtgcgcttgt ttgtcttgta gcgtcatgtc cgtgtgctat tgttatttcc
     7381 gtacctctct cctactattc gggtatcggt gcggcatccg aagttggtgt actcatcaag
     7441 ggcggaaaat atattgaggc tcttgcaaaa gcagatacat tcgtattcga taaaacaggc
     7501 acgctcacaa gcggcaagct cagcgtaaac aaggttaata cggtaggttc atacagtgct
     7561 gacgaagttc ttgctcttgc cgctgcaagc gaaaaatatt ccgctcatcc gattgcatcc
     7621 gcaatcagag aaaaggcaaa cggtcttaaa ctccccgagc tttccgacta cagcgaaagt
     7681 gccggtcacg gaacaagcgc agtttataac ggcaaaacta ttcagtgcgg cggttcaaag
     7741 attctttcgg acgagcagaa gaagattgca aataaagacg attctgtttt cgtaatttat
     7801 gacggtcagc ttatcggttc gctcaatgtc agcgacacgg taagacctga ggcaaaagag
     7861 gttatctcac agcttaaagc gctcggtgtc aagaacacgg taatgctcac aggcgacaga
     7921 caacagcctg ccgaaaatgt taaaaacgaa ctcggacttt ccgaatgtca cgcagagctt
     7981 ctccctgctc aaaagcttga acttttcaag ggcttgaaat caaaatccaa gggtgcttgc
     8041 tttgtgggcg acggcatcaa tgatgcccct gttctttcgg caagcgactg cggtatcgca
     8101 atgggattcg gcagtgaagc cgctattgaa gcgtcagacg cagttcttgc atcaggcaca
     8161 ctcaaacagc ttccaaaggc aattaaaatt gcaagaagtg ttatcaacac agtcaagggc
     8221 aacatcatct ttgccctctc aatcaaggct cttgtaatca tcctcgccgc attcggtctt
     8281 gcacaaatct ggatgtccgt tatcgccgac acaggcgtca gcgtagtctg cgtcatcata
     8341 gccgcaagac tcctcaaaaa gaaatattga tttttttgca aatcatatca tttattatga
     8401 taaagcaccg tgagctttca caagtttcac ggtgctttca tttgccaaaa tttttctaaa
     8461 cataatctta tattatagta ttttaaaatt attgactttt ataattatat aaattataat
     8521 gtttttgtca gcgcttgtaa ctgataaata aacttcggag agattaattt gaaaaagata
     8581 tttttattat tagtaaccgc tttattttta ctttcattat atggatgtaa cacttcttca
     8641 tcaagcaata attccactga acaaacaacc gtaacgaata cagatgattt atctcttgat
     8701 acagatacag attctgaaac agaatttaat tacgatttgg agatttacta taacgataaa
     8761 aagattgata atttaaatct tttcgatgca tttatgccaa ctgaggatgg actcatatat
     8821 tcaaaaatca acgaaacttc tccgaatgaa atagaatact acagatacta tttagacaaa
     8881 aagagcagta taaaactcgg ctcaataaaa gactggacaa tgcaaattaa cgataaagcg
     8941 tatgtaaata atcacttatg ttttatggca agcacgggtg acattacaga tgaagaaaac
     9001 agaacccttg aatttattga tatagacctt aataaaaaca aaatgactac tgtcttttct
     9061 gacaaaggcg gttttcccta tgataccgtt acaggtgcag acaatcttgt cataattaca
     9121 aaagtattaa acaacggtac ttctttggaa ctgtatgaca ccgaaacgca aaagtttaaa
     9181 caactgaaat atttagagtt tgatgataag aactgtgtag gaaaaactat aagaaaagtt
     9241 tcaattgacg acaaaacaaa aacaatctgc ctcttggttt tggactgtgt ttcggaaaca
     9301 gatgtttctt taaaaataga aacctatgac tatgatatga attttcttaa aagctacgat
     9361 atctccaata tttcggatga ttctaacgaa ttgattcaag gagtgcagtt ttttgatttt
     9421 agaaacaact accttatcta tcaaaatttt agtataacaa gatgtatagg ttatataggg
     9481 aataaaaaat tgcaaaaatc cgatatgatt gacaacattg acgacaccta ctctatggct
     9541 caaactccac aaaaaggata taatacagtt ttatcattta aagatgttga tttagaacgc
     9601 aatatatact tatttaatac cattgacaaa acaatgaaaa aaacaaaatt caaacctgaa
     9661 gaagaaaact actatatcgg ctcaatgtca agaactggaa aagataattt gatgataata
     9721 acaactcctg ataatgcaga caaaaaaagt aatcttaatc caaaactata ctttacaaaa
     9781 ttaagcgact taaaatttca gtaaacaggc ggtaaaaatc aattaaaatc cattttgcaa
     9841 attatctgtc aaaatcctgc aaaaaattta atttatgggc aatactgctc tttacttttt
     9901 aaggtattta ttgtataatt agcggtaaag taaaaaggta tatttaatgt tacaaaacac
     9961 cttttgctca caataaaaag gataggaggg acaaaacata atgatcagcg gtgctgaaat
    10021 tatggtaaaa tgtttggaag ccgagggcgt tgacatagtc tttggttatc ccggtgcggc
    10081 tatttgccca ttttacgata aagtttacga ttcgagcatt acccacattc ttgttcgtca
    10141 ggaacagaac gctgctcatg cggcaagcgg ctatgcaaga tgcagtaatc gtcccggtgt
    10201 ttgcgtggca acttccggtc ccggtgcaac caacctcatc acaggcattg caaccgccta
    10261 tacggactct attccgattg ttgccattac aggtcaggtt cgttccgacc ttctcggcag
    10321 agatgtcttt caggaagctg acatcacagg agcttgtgaa ccgtttgtaa agcacagtta
    10381 tctcgtcagc aaaacagaag accttccgag agttttcaaa gaggctttcc atattgcctc
    10441 aaccggcaga cctggtcctg tacttatcga cattcccgtt gatattcagg aaaatgaaat
    10501 tgaaagtttt gaatatcccg aaagcgtaaa cattatcggt tacaagccga acactaaggg
    10561 acacgcaatt caggttaaaa aggctgttga ggccatcaac gcaagcaagc gtcctgttat
    10621 cgtatcaggc ggcggcgtgc tgagttcggg tatcaagctt aaacttcaaa aatttgcaga
    10681 aactacgggt atccccgtta tttcaactat gatgggcatc ggtgttatgc ccagcgagca
    10741 tgagctttat ctcggaatgc tcggcactca cggcaaggct gttgccaacc gtgctcttca
    10801 cgaagccgac cttgtaatcg tatgcggtgc aagactcggt gacagagctg ttgcggctcc
    10861 cgaccagatg agtgaaaaca caaaggtaat tcacattgac attgaccctg ctgaaatcgg
    10921 taagaatgtt aaaacagaaa ttccgattgt aggcgatatg aaaaatgtca tcaatatgct
    10981 gcttgacagc atcggcgatt acaaggttac aacaatgtgg agcgaaaccg taaagaactg
    11041 gaaaaaagac ctttaccgtg agcctcccgt ttttgacggc tttgttgagc cgagaacact
    11101 tgtcggtcat ctcagtgcaa tgttccgctc aaaggcaatt cttgttgccg atgtaggaca
    11161 aaatcaaatc tggtgtgcaa acaacttccg tattcgtgag ggcagattcc tcacaacagg
    11221 cggtatgggt acaatgggtt actcaattcc cgctgcaatc ggtgcaaagt ttgcaagacc
    11281 cgaccgtgat gttattgtaa tctgcggtga cggcagtttt cagatggggc ttaatgagct
    11341 tgcgactatt gcaggcaatc agctcggaat taaaatcatc attatgaaaa acgcacgact
    11401 cggaatggtt cgtgaacttc aggacaaaca ctacggtggc agacactccg caacaattct
    11461 caacggtgat cccgacttct tgaagattgc cgatgcttac ggcattgacc atgcagaggc
    11521 tcattcaaac aaggaagccg aaaacatcat caagggtatt gttgattcgg aaaaaccgtt
    11581 cattcttgtt tgcgatgttc accccgacac tccgtcaatt taatgaggtg ataaaatgca
    11641 gtatacatta tcaatacttg ttgaaaatca ggcgggcgtt ctttcaaaaa tttcgggact
    11701 tttctctcgc cgaggtttta acatcgactc acttgcagta ggtgttactc aggacccgtc
    11761 ggtttcccga atcacaatcg ttgcaaacgg tgacgagtac attgttgaac agcttgaaaa
    11821 acagctcaac aagctcattc ccgtcatcaa ggtaaaaagg cttaacgagg gcgaatttat
    11881 cagccgtgag cttgttttaa tcaaggttca ctgcgccgcc tcaaaaagag ccgaaattgt
    11941 caaaacggtt gaaattatgc aggcgaaaat cgttgatgta tccccttcgt cagttaccgt
    12001 tgagtactgc gaatgtgcaa gccgcatcaa cacgcttgtt gacttactca agccttatgg
    12061 tatccgtgag attgtaagaa caggtactgt tgccattgac agaggcacag cttcggtttc
    12121 cgtttaatct tacagttagc atatatttta atttatatgc cgcgtttgcg gtaaggagga
    12181 ctttaatatg aaagactaca caaaaaacat gacagcacca atctactatc agtcagattg
    12241 taaccttgac cttctcaagg gtaagaaaat tgctattatc ggttacggca gccagggtca
    12301 tgcacacgct ctcaacctca aggattcagg ttgcgatgta atcatcggtc tttacaaagg
    12361 cagcaagagc tgggcaaagg ctgaggcaca gggctttaag gtatatacat cggcagaagc
    12421 tgcaaagcag gctgacatca tcatgattct tatcaacgat gaaaagcagg cagctcttta
    12481 caagaacgac atcgagccaa acctcgaagc aggcaatatg cttatgttcg ctcacggctt
    12541 taacattcac ttcggttgca tcaagcctcc aaaggatgtt gatgttacaa tggtagctcc
    12601 taagggaccg ggtcacacag ttcgttcaga gtatcaggtt ggtaagggtg taccttgcct
    12661 cgttgcagtt gagcaggatg ctacaggtca ggctaaggat ctcgcacttg catatgcact
    12721 cggtatcggc ggtgcaagag ccggcgttct tgaaacaaca ttcagaacag aaacagaaac
    12781 agacctcttc ggtgagcagg ctgttctttg cggcggtgtt tgcgcactta tgcaggcagg
    12841 ttttgaaaca ctttgcgatg caggttacga cccaagaaac gcttactttg agtgtatcca
    12901 tgagatgaag ctcatcgttg accttatcta tcagtcaggt tttgcaggca tgagatattc
    12961 aatctctaac acagctgagt acggtgacta catcacaggt ccaaagatca tcacagagga
    13021 tactaagaag gctatgagaa aggttctttc tgacattcag gacggtacgt ttgctaagga
    13081 cttcctcctt gacatgagcg atgccggttc acaggttcac ttcaaggcta tgagaaagat
    13141 cgctgccgaa gctcctgccg aagtattcgg taaggaagtt agaaagctct acagctggtc
    13201 tgacgaagat aagctcatca acaactaatg ttttttagtt cgtgaagtta gtttgatata
    13261 ttcaaatttc tgtcacccga gcattacata gtacgaattt agggtagctt gattttcaag
    13321 ctaccctttt tgcgagtgcc tcgctcttag ttcgtgtagg tagtttgtga taatttacaa
    13381 ctacttgttt ccaagcttaa catagtacag attaacagtt cagtcaattt ggctgaaccg
    13441 ttttttcgtt gtgcaataaa agggttcagc tttttacggc tgaacccttt tacagttaaa
    13501 acttattaat ttttaaataa tcaatacttc tcataggaga aagaattata agcatcaagc
    13561 aaagactgct tattctcagc ggtagttttc tcaccccata cgctggtatc accataacct
    13621 gtcacaataa atttggtaaa catatgtgca tttacgcaat tattaaactg tttaaggtta
    13681 atttcgttat attttgcccg tgaaatattt ttgtcattac cgtcaaaata tctataataa
    13741 atattattat ttgattcttc gcctacgcct cttgccgaat acatatttgc aaaaagattc
    13801 tctccgtcgt atgtgattat tgaattaccc gaccaatagt aaccgtcatc tacatttaaa
    13861 gatatcttta ggtcgtgaac ctcatacttt ttggcagttt tattatagta tatcgcaaaa
    13921 ccgtcgttaa catttcccac tctttttaac ttaccgtctt caaatttgta aacaacggaa
    13981 tggaaactat actcattgga atcagccttt tgtgcaacaa gctccggaac tccgtcaaag
    14041 tcgaaatcca aaaacataac acctgacaaa ttgtgattac ttcccaagct tggcatccat
    14101 tcactctgat gattcatcat ataattgata taagcgtccc ttgttttatc agatgtctta
    14161 tacctgtatg ttacaccggt tgggttaaac atcgtagtaa actttttacc gtcttttgaa
    14221 acacctctta ccgtataagt gttactgccg gactttgcac ccttgtgaac ataatagttg
    14281 tcataagttt ctgctatcct cttccaaaaa ccgttttctt taatataaac acggaacttt
    14341 ggcgcatctc ccgtccaatg catttcaata ccgttgttta ctgcaccaat gctgtaaatt
    14401 tcgggacaat cctgatgatt gccaataggc gtaccctttg aatcgtagcc gcttgtaaaa
    14461 cttttggcat ccttgctgat acaacgaacc gtgtaataaa tatcatcaat gcttaaatca
    14521 aattcctttg aaacaacatt catatcaagc atagtcgtgc ctgttgtatc ggcaagcttt
    14581 gtccaaccgt ttctgtcctt gtagtacaca cgatacttct ctgcacctgc aactttgttc
    14641 catgtcagct ttacgccgtc atatgtgacc tcaagttttg aaattttcgg tgtggcaaca
    14701 tactttaccg acttgcctgt cgggttataa ccgcttgtaa atttctttgc gtctgatgtt
    14761 atacatctta cagtata
//
