LOCUS       c00274_gnlPro..        16743 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KFOPJACC_274.
ACCESSION   c00274_gnlPro..
VERSION     c00274_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 02:03:40
            Original ID  :: gnl|Prokka|KFOPJACC_274
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16743
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16743
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3194:6743](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3195..6743
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16743
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16743
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             3..608
                     /locus_tag="ctg274_1"
                     /transl_table=11
                     /translation="GIEAPSSMFSEYRVDSNNPIPLIYQSGYLTIKDFDREFGNYLLQF
                     PNDEVRYGFINFLVPFYTGVRNSDQGFYIGKFVQELRSGDYDAFLTRLQAFFADFTYEL
                     NEQTERHYQVVFYIVFKLMGQFTDAEVRSARGRADAVVKTPKYIYVFEFKLHDTAEAAL
                     KQIDDKGYLIPYQADGREVIKIGVEFSAEKRNISRWLV"
     CDS             complement(619..1851)
                     /locus_tag="ctg274_2"
                     /transl_table=11
                     /translation="LQNKVLNSFEMTKKALYIFNPEHDLALASGETNYMAPASARRMAS
                     ELALLPMWYAEEGSAVLASSAYNLDYLKQMQELLGVSIHLMTEPELAVGPDLDIRPWGW
                     DVALRKRLSGLGVDEALLPSMEQLNGLREYSHRSKAVSLLPELQLNEYFCGESYYLKTQ
                     EEWKTFVEERECCLLKAPLSGSGKGLNWCKGIFTPFISGWCTRVAASQGGIIAEPIYNK
                     VEDFAMEFYSDGTGEVTFMGYSLFHTGKSGMYEGNRLLSNEAIWKQLSQYVPSKVLTDL
                     ENCLKYRLSALVGTVYKGYLGVDMMICRFPENEKPVFRIHPCVEINLRMNMGVVARFLY
                     DRYVRSGSTGRFVIDYHPSEGEALQEHERMSATYPLEIREGRVYSGYLPLVPVHRRSCY
                     RAWIWVTPDNI"
     CDS             complement(1990..2283)
                     /locus_tag="ctg274_3"
                     /transl_table=11
                     /translation="MFEHLVDQQYFSATFLKFVGEVYNAVAREIEVVHVDEQTGTVVPE
                     FLFGVLEKESGFSYATCPFDTNQAVAPIDLVHKIAANGGIGVLNEVGVCAVE"
     CDS             complement(2443..2673)
                     /locus_tag="ctg274_4"
                     /transl_table=11
                     /translation="LFDEKYIYFHHHVHRFQQILRKVTLFEEERIEAVVQIILEIIQRT
                     DFGEYSFGNLFVSAKNFFETVCPEFHACLQV"
     CDS             2794..3162
                     /locus_tag="ctg274_5"
                     /transl_table=11
                     /translation="MNYIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVK
                     VEEQDVLDTFFANSLWKDHKVHKGDKNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHK
                     AEIGRGNQIPLWMFGFLY"
     CDS             3195..6743
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg274_6"
                     /sec_met_domain="PFOR_II (E-value: 1.4e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.6e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.4e-31, bitscore: 100.6,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.1e-12, bitscore:
                     37.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 5.7e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1e-07, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.7e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 3.5e-25, bitscore: 78.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDNPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     EQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTAKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAQAENWTYCAENVKTKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIAADGTPAEVKELFAEWINNMLDADKTKE
                     LAAKIIPVVEANKDKCNHCKQIAELQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAKW
                     RYNSYKRLARENWGAE"
     CDS             complement(6896..7762)
                     /locus_tag="ctg274_7"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAILLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRQLVDSW
                     IPKSENK"
     CDS             complement(7783..8607)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg274_8"
                     /sec_met_domain="BPD_transp_1 (E-value: 3.5e-29, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETVINWMMVHFSTFFDAINAGIGSFIIGFQHVLFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8604..9806)
                     /locus_tag="ctg274_9"
                     /transl_table=11
                     /translation="LYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKDANLSINEG
                     EFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRRKELAMVFQ
                     NFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGELSGGMQQR
                     VGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITHDLSEAIKL
                     GDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMIDKPLVARLK
                     KEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSRQEKSIETIVRTEVHSV
                     LEDTVLEDILPLMTKSNSPVWVIDETHEFLGTIPLSSLIIEVTGKDKEEINEIIQNAID
                     L"
     CDS             complement(10130..10468)
                     /locus_tag="ctg274_10"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMPQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10564..11940
                     /locus_tag="ctg274_11"
                     /transl_table=11
                     /translation="LLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLFGVFAFS
                     SCEKNLYDESKQPEKEIQVKDLDIPAGFQWKLTQVAAGTVAATTPTMVSFFLDEACSKE
                     EKIADIPVDTEISSLPLSIPTYVNTLYAQYKTSTNETKKVAIPVNADRSFSLNIANDAK
                     SKSNTTRSITRGHDIEDDIQLSKGVIFHPKDGWGTIMFEDQFPSLGDYDFNDFVVNYKV
                     QFQGIRKVDKKYTAQYIQIGLRLKAIGGIFPYSPYLRLKEIDSDEVESIEVYETKNVIP
                     AIDGVELVPNKHLIIDYSPLIKNLAKPAGSQYYNTEKNALVATSDLPEINILITLKKRK
                     EVKEILEGDEFDLYLKRNDSGTEIHMNGIEPITYQYPFNDKNLLPVYTNGDEEDDNYYF
                     SAGRLIWGLRVPGNAAHAIEKANFLEAYKGFAKWAQSSGKNEQNWYNQGNADKSLLIHN
                     "
     CDS             complement(12021..14864)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 61.5; E-value: 2.8e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg274_12"
                     /sec_met_domain="Peripla_BP_1 (E-value: 1.1e-19, bitscore:
                     61.5, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRMIRMMGYTKWIAVLLCLLGMTACRQDAPRFRIGVAQCSDDSWR
                     HKMNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDEGVDLLIISANEAAPMTPI
                     VEEAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLG
                     GSTPAMERHQGFMAAISNFPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHND
                     RIAPGAYQAAKKVGREKEMIFVGIDALPGKGNGLEMVLDSVLNATFIYPTNGDKVMQLA
                     MNILEKKPYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQ
                     QVVMYGGLVILLLVAGLLLVVYKSLRAKNRLNKELSEQKKQLEEQRDKLEEQRDQLEEQ
                     RDKLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADHTLSGD
                     QHRMLMLIQRNVNILLRLVNQILDFRKYENGKMEYTPVQVDVLSSFEGWNESFLAAARK
                     KHIHFSFDNMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGKITVRLSSLMKEDTRW
                     IRFTVANTGSMISAEHIRSIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTISVESDEK
                     QGTVFTVDLPVQTCETILAEDSLKSSISAVPLNPASPGSPASSDLNETLAAEEEELEKG
                     YDSSKPSVLVIDDNADIRSYVRGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMP
                     GIDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARV
                     RNLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKTLIEAKMGDSNLNVEDLGKDMG
                     LSRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKC
                     YKEQFGESPTDLLKRKG"
     CDS             complement(15282..16169)
                     /locus_tag="ctg274_13"
                     /transl_table=11
                     /translation="MNNIIVGMGEALWDVLPEGKKIGGAPANFAYHVSQFGFDSRVVSA
                     VGKDELGDEILNVFNEKKLKTQIEQVDYPTGTVQVTLDNEGVPCYEIKEGVAWDNIPFT
                     DELKRLALSTRAVCFGSLAQRNEVSRATINRFLDTMPDIDGQLKIFDINLRQDFYTKEV
                     LRESFRRCNILKINDEELVTISRMFGYPGIDLQDKCWILLAKYNLKMLILTCGINGSYV
                     FTPGVVSFQETPRVPVADTVGAGDSFTAAFCASILNGKPVPEAHKLAVEVSAYVCTQSG
                     AMPELPQVLKDRLM"
ORIGIN
        1 acgggatcga agcaccgtct tccatgttct ccgaatatcg tgtagattcc aataatccga
       61 ttccgttaat ttaccaaagt ggctatctga cgataaaaga tttcgatagg gaatttggta
      121 actatctatt gcaatttcct aatgatgaag tccgctacgg cttcattaat ttcctggttc
      181 cattttacac cggagtgaga aacagtgacc aaggatttta catcggcaag tttgtacaag
      241 aacttcgttc gggagactac gatgcctttc ttacccgcct gcaagccttc tttgccgatt
      301 tcacctacga attgaacgag cagacagagc gtcactacca agtagttttc tatattgtct
      361 tcaaacttat gggacagttc accgatgccg aagtacgcag cgcccgcggt cgtgcagatg
      421 ccgtagtgaa aacacctaaa tatatctatg tcttcgaatt caagctgcat gacacagcag
      481 aagcggcatt gaagcagatc gacgataaag gctatctgat accgtatcag gcagacggac
      541 gtgaagtgat aaagatcggg gtagagttca gtgcggaaaa acgcaatatc agtcgctggc
      601 tggtgtgaac agataaagtt aaatattatc aggagttacc catatccatg cgcgatagca
      661 acttctccta tgaacaggaa ccaaaggtaa ataaccggag tacactctac cttccctgat
      721 ttccaacgga taagttgcgg acattcgttc atgttcctgc aaggcttcac cttccgaagg
      781 atgataatca atcacaaaac gccctgttga accagaacgt acataacggt catataaaaa
      841 acgcgcaaca actcccatat tcatgcgcag attaatttcc acacagggat gaatccgaaa
      901 aaccggcttt tcattttccg gaaaccgaca aatcatcata tcaaccccaa gataaccttt
      961 ataaacggtt cctaccaacg cagaaagtct atatttcaaa cagttctcca aatccgtcag
     1021 aacctttgaa gggacatatt gcgaaagttg tttccagatt gcctcattag aaagcaaacg
     1081 attcccttca tacattccac tctttccggt atggaagagg gaatatccca taaatgtcac
     1141 ttcacctgta ccatcggaat aaaactccat ggcaaagtct tctaccttat tatatatagg
     1201 ttccgcaatg attccaccct gcgaagcagc cacacgcgta caccaaccgg atataaaagg
     1261 agtaaatatg cctttacacc agttcaagcc tttaccgctt cccgaaagcg gagctttcaa
     1321 caggcagcat tcccgctctt ccacaaaggt tttccattct tcttgtgtct tcaaataata
     1381 agattctccg cagaaatatt cattcagttg taattccgga agcaatgaga cggctttaga
     1441 acgatgggag tattcccgca gaccgtttaa ttgctccata gaaggcaaca gggcttcatc
     1501 cacgcccagc cctgaaagcc gtttccgcaa agctacatcc cacccccaag gacgaatatc
     1561 caaatccggt ccgacagcaa gttccggttc agtcatcaaa tgaatcgaaa ctcccagcaa
     1621 ttcctgcatt tgcttcaaat aatccagatt ataagcggaa gaagctaata cagcactccc
     1681 ctcctctgca taccacatcg gaagcaaagc caactcggaa gccatacgtc tggccgaagc
     1741 tggagccata taattagttt caccgctggc caacgccaag tcatgttccg gattgaatat
     1801 ataaagagcc ttttttgtca tttcaaatga attcaaaact ttattctgca aatatataca
     1861 ggaaatagtc aggaatgact acaataaaca gaaagttgga attaaacaca caattttgcc
     1921 atctctactt tgcaaatcct aaaaaaagca gtatatttgc cacccgaaaa acaaagaact
     1981 gaaatggaat cattctaccg cacacacgcc tacctcgttg agcacaccaa tgcccccgtt
     2041 cgccgcgatc ttatggacga gatcgattgg agcgaccgcc tgattggtat caaagggaca
     2101 cgtggcgtag gaaaaaccac tttccttctc caatacgcca aagagaaatt cgggaacgac
     2161 cgttcctgtc tgttcatcaa catgaacaac ttctatttct cgggccacag cattgtagac
     2221 ttcgccaacg aatttcagaa acgtggcgga aaagtattgt tgatcgacca ggtgttcaaa
     2281 catccggaat ggagcaaaga gttacgcatg tgttacgacc gttttcctaa cctgaaaatt
     2341 gtcttcaccg gctcgtccgt gatgcgactg aaagaagaaa atcttgaatt acgtgatatc
     2401 gccaagagct ataacctgcg tggattctct ttccgtgaat tcctaaactt gcaaacaggc
     2461 atgaaattca gggcatacag tctcgaagaa attcttagca ctcacgaaca gattgccaaa
     2521 ggagtactct ccaaagtccg tccgttggat tatttccagg attatctgca ccacggcttc
     2581 tatccgttct tcctcgaaaa gcgtaacttt tcggagaatc tgctgaaaac gatgaacatg
     2641 atggtggaag tagatatact tctcatcaaa caaattgaac tgaaatatct ttcaaagata
     2701 aaaaaattac tatatttgct cgctgtcgac gggccgaaag ctccaaatgt gagccaacta
     2761 gcaagcgaca tacagacatc tcgcgccacg gtgatgaact atatcaagta tctggcagat
     2821 gcgcgactca ttaatctggt ttatccgaaa ggggaagaat tccctaaaaa accttcaaag
     2881 ataatgatgc acaactccaa cctgatgtat tccatctatc cggtgaaagt ggaagagcag
     2941 gatgtgctcg acacattctt tgcaaattct ttatggaaag accataaggt acataaagga
     3001 gataaaaacg tctcttttat ggtggacgaa gtaatgccgt tcaaaatttg ccaggaaggc
     3061 gcaaagatca agaacaatcc gaatgtaacg tacgcgttgc ataaggctga aataggtcgg
     3121 ggcaaccaga tacctctctg gatgttcggc tttttatatt aaaagattta tttacttaaa
     3181 tatttaattt agttatgact aaacagaaga aattcatcac ttgtgatggt aaccaggctg
     3241 cagcgcatat ctcgtatatg ttctctgaag tagcagctat ctaccccatc actccttctt
     3301 cgactatggc tgagtacgta gacgaatggg ctgccgcagg acgtaagaac atcttcggcg
     3361 aaacagtatt agtacaggaa atgcaatctg aaggtggtgc tgccggtgca gttcacggtt
     3421 ctcttcaggc tggtgcgttg actactactt acactgcttc ccagggtctt ctcctgatga
     3481 tccctaacat gtacaaaatt gccggtgagt tcttgccttg cgtattccat gtatctgctc
     3541 gtacattggc ttctcacgca ttgtgtatct tcggtgacca ccaagacgta atgtcagctc
     3601 gtcagactgg ctttgctatg ttggctgaag gctctgtaca ggaagttatg gatttggctg
     3661 gtgttgctca cttggctacc atcaaatctc gcgttccgtt catgaacttc ttcgatggtt
     3721 tccgtacatc tcacgaaatc caaaagattg aaatgttgga aaatgatgat cttgctccgc
     3781 tgatcgacca agaagctttg gctgaattcc gtgcccgcgc actgaacccg atgaaaccgg
     3841 tagctcgtgg tatggctgaa aatcctgacc atttcttcca acatcgtgaa tcatgcaaca
     3901 actactatga agcagttcct gctatcgtag aagaatacat gaatgaaatt tctaagatca
     3961 caggtcgtaa atacggtttg ttcgattact atggtgcaga agatgcagaa cgcgtaatta
     4021 tcgctatggg ttctgtaaca gaagctgccc gcgaagctat cgactacctg gtagcaaacg
     4081 gcgaaaaagt gggtatggtt gccgtacacc tgtatcgtcc gttctctgct aaacacttct
     4141 tggctgctgt acctaagact gctaaaacta tcgcagttct tgaccgtact aaagaaccgg
     4201 gtgctaacgg cgaacctctt taccttgacg ttaaagactg cttctacggt gcagaaaatg
     4261 ctccggttat cgttggcggt cgctacggtt tgggttcaaa agatactact cctgctcaaa
     4321 ttctttcagt attcgaaaac ttggctatgc caatgccgaa gaaccacttc actatcggta
     4381 tcgtagacga cgttactttc acttctcttc ctcaaaaaga agaaatcgct ttaggcggcg
     4441 aaggtatgtt cgaagctaaa ttctacggtt tgggtgctga cggtacagta ggtgctaaca
     4501 agaactctgt aaagattatc ggtgacaaca ctgacaaaca ctgccaggct tacttctctt
     4561 atgactctaa gaagtcgggc ggtttcactt gttctcactt gcgtttcggt gacaatccaa
     4621 tccgttctac ttatctggta aatactccga acttcgttgc ttgtcacgtt caggcttacc
     4681 tgcacatgta cgatgtaact cgtggtttgc gtaagaacgg ttctttcctg ctgaacacaa
     4741 tctgggaagg tgaagaactg gctaagaacc tgcctaacaa ggttaagaaa tatttcgcac
     4801 agaacaacat ttctgtatac tatatcaacg caacacaaat tgcactggaa attggtttgg
     4861 gtaaccgtac caacacaatc cttcaatctg cattcttccg tatcacaggc gttattcctg
     4921 tagaacaagc tgttgagcag atgaagaaat tcatcgttaa gtcttacggc aagaagggtg
     4981 aagacgttgt taacaagaac tatgctgccg ttgaccgtgg tggtgaatac aagactttgg
     5041 ctgttgatcc tgcttgggct aaccttccgg atgacgcaaa agctgaaaac aacgatcctg
     5101 cattcatcaa cgaagtagtt cgtccgatca atgcacaaga cggtgacttg ttgccggtat
     5161 ctgcattcaa gggtatcgaa gacggtactt ggtatcaagg aactgctaaa tacgaaaaac
     5221 gtggtgtagc tgcattcgtt cctgaatgga atgctgaaaa ctgtatccag tgtaacaagt
     5281 gtgcatacgt ttgtcctcac gcttctatcc gtccgttcgt actcgacgct gaagagcaga
     5341 agggtgctaa gttcgaacaa ctgaaagctg taggtaaagc attcgacggt atgacattcc
     5401 gtatccaggt agacgttctc gactgtctgg gttgcggtaa ctgtgctgac atctgtccgg
     5461 gtaatccgaa gaagggtggc aaagcattga caatgaaaca cctcgaaagc caattggctc
     5521 aagctgaaaa ctggacttac tgtgctgaaa acgtgaagac taaacaacat cttgttgata
     5581 tcaaggctaa cgtgaagaac tcacagttcg ctactccgtt gtttgagttc tccggcgctt
     5641 gctctggttg tggtgaaact ccatacgtga aattgatttc tcaattgttc ggtgaccgtg
     5701 aaatggttgc taacgctacc ggatgttctt ctatctactc tggttctgtt ccttctactc
     5761 cgtatactac aaacgaaaac ggacacggtc ctgcttgggc taactcactg ttcgaagact
     5821 tctgtgaatt cggtttgggt atggaactgg ctaacgaaaa gatgcgtgct cgtctcgtga
     5881 aagtgatgaa cgaggctatt gctgctgatg gcactcctgc tgaagtgaaa gaactgttcg
     5941 ctgaatggat caacaatatg ctggatgcgg acaagactaa ggaattggct gctaagatca
     6001 ttccggttgt tgaagctaac aaggataaat gtaaccactg caaacaaatc gctgaactgc
     6061 aacaatatct tgtaaaacgc agccagtgga tcattggtgg tgacggtgct tcttacgata
     6121 tcggttacgg tggtcttgac catgtaatcg cttccggtaa ggacgttaac atcctcgttc
     6181 tggatactga agtttactct aacacaggtg gtcagtcttc taaagctact ccggtaggtg
     6241 ctatcgctaa gttcgctgct gctggtaagc gcgtacgtaa gaaagacctc ggtctgatgg
     6301 ctactactta cggttatgta tatgttgcac agatcgctat gggtgctgac caagctcaaa
     6361 ctctgaaagc tatccgtgaa gctgaagcat atccgggacc atctttgatt atcgcttatg
     6421 ctccgtgtat caaccacggt ctgaaagcag gtatgggtaa gagccaggaa gaagaagaaa
     6481 aagctgttaa gtgcggttac tggcacttgt ggcgttacaa cccggctttg gaagaagaag
     6541 gcaagaaccc attccaattg gatagcaaag aaccgaactg ggaagatttc caaggtttct
     6601 tgaagggtga agttcgttac gcttctgtaa tgaaacaata tcctactgaa gctgaagaac
     6661 tgttcaaagc tgctgaagaa aacgctaaat ggcgttacaa cagctacaaa cgtttggcta
     6721 gagaaaactg gggtgctgaa taatagtaat accctataaa tataaaacgg taatcttgta
     6781 gaagattacc gtttttttat tgtatgaact ctgtctaaca taaacaatac tccctttttc
     6841 ccactagagt tcatgtctat tttatattta aaattaagaa taacaatgct ccaatctatt
     6901 tattctcaga cttcggaatc caactatcca ccaactgccg atgttcatcc ctccatttgc
     6961 gggctatttc ttcttcatcc atccgggcat ccttcatagc tgtcataaaa gagctaagtt
     7021 cttctgtcgt tagtttaatg ttgccaaaga attcggcagc aaacggatct ttctcactga
     7081 atcctttcca tgcaatagca tgtatttctt ccaagtctcc atatactttc ttcggatcat
     7141 ccaagaattt caagtcaaac tggtcgaaca tccaatgcgg tgtccacccc gtgatgacaa
     7201 tccattctcc tttgtccatc gcttttttca aagaagccag catggtggaa ctacttgaag
     7261 tcatgagggt atacccatca agtccataag cagcaatggc cttatcggtc gtcttcatta
     7321 tccctgctcc ggcatcaatt cccactattt cggaagagaa acggtcttta ttagcttcca
     7381 gctcactaat agactgaatc gtaacatatt gaggaacaac cagccctaca cgggcttctc
     7441 catatacctc acccagaaat tcgatgctgt ctccatactg atccatataa tctttcatcg
     7501 ttattggtaa ccaggcatcc agaaacacat ctgatttctt tcctgacata gatacaaaaa
     7561 taggggcaag atcagcattt tgcaattcaa cctcatatcc atgttcttcc aataccacct
     7621 tagccaaatg gctcatggca ataccttcca accaattggc ataggctatt tttactttct
     7681 ttttctctaa gtctgaatta gtacaggaag ccagcaaaag tatagctgac aatactattc
     7741 ctactatttt atatattctc atacgtattt tatcctttcc gtttagttct tgttttttcg
     7801 tcctgccatt ccttgtgtga tacggtctaa gatgatagct aaaataacaa ctgcgatacc
     7861 accttcaaac ccaagtccga ttttcatttg ggtaatacct ttcaatacaa tttctcccag
     7921 accaccggca gcaatcatgg cagcaatgac aaccatagaa agcgacatca ttattgtctg
     7981 attgacacct gtcaggatgg ttggcaacgc caaaggaagc tgcactttat acaataactg
     8041 ccaacgggta gccccgaacg aacgggaagc ttccactaca tttttaggaa cttgccgaat
     8101 tcccaatcca gtaaggcgga ccacaggagg catagcaaag ataatggtgg caaacactcc
     8161 cggcactgct cccaatccga aaaacaaaac ggcaggaatc agataaacaa aagcaggcat
     8221 cgtctgcatt aagtcgagaa caggacgaag tattttctct gcacgcggac tgtttgccgt
     8281 ccacactcct aaaggtacac caacaatcag ggccagacag gtagatgaaa aaacaagagc
     8341 cagggtttgc atagtagcct cccaaaatcc cattccataa atcagtaata atcccaatgc
     8401 ggtgaaaatt gccgtaccac gtcctgcctt catccatgcg agtgcagcaa gcactagaat
     8461 ggttatataa aaaggtattc caaaaagtac gtgttggaat cctataataa aactaccgat
     8521 gcctgcattt atggcatcaa agaaagtgga aaaatgtacc atcatccaat tgatgaccgt
     8581 ctctatatat tgtcctatat ttatcataaa tctattgcgt tttgaattat ttcgtttatt
     8641 tcttctttat ctttccccgt cacttcgatg attaaggagg aaagcgggat tgttcctaaa
     8701 aactcatgcg tctcatcaat cacccatacc ggcgaattgc tctttgtcat taaaggaagt
     8761 atatcctcca acactgtatc ctccaataca gaatgtactt cggtacgcac aatcgtttca
     8821 atggattttt cctgtctgct acgtaactta agcaggtcgt tcagacgtac ttctccgacc
     8881 agtttatcat cggcgtctat gacaggtaat acggtgatat tcttcgcacg catcttacga
     8941 atcaatactt caggtccctc tttcttcaga cgggccacca gtggtttgtc aatcattaaa
     9001 gaagaagcgg taataatttt actcctgtcc acgttttcaa caaaacgggc tacataatcg
     9061 ttagccggtt cggtcagtat ttcttctgaa gtacctacct gcaccacctc tccgtctttc
     9121 ataatagcaa tacggtcgcc cagtttaatc gcttcactca agtcatgggt aataaagaca
     9181 attgtttttt tcatcttcga ctgcaaagcc agcagttcat cctgcatttg cacacgaatc
     9241 agaggatcga gcgcagagaa agcctcatcc attagaagta cttcgggatt attagccaga
     9301 gcgcgggcca gtccgacacg ctgttgcatt ccaccggaaa gctcgcccac catctgattt
     9361 tcatatcctt tcaatccgac aagcttcatg ctttccatcg ctttcttctc acgttcctct
     9421 ttcttcactc cctgaagttc gaggccgaac gcgatattgc tcaatacgga acggtgaggt
     9481 aacagaccga aattctggaa aaccatcgcc agctctttcc gacgaacctg caataattct
     9541 ttttcggaaa ttttagatat atctactccg tttacaagca cttgcccggt agtaggacgt
     9601 atcagacgat tgatacaacg cagtaatgtc gattttccac ttcccgagag tcccattatc
     9661 acgaaaaact ctccttcatt aattgaaaga ttggcatctt tcactcctac cgtacaaccg
     9721 gtatctttca gaatttcctc tttactctta tcttttttca acatcttgag ggctttctgc
     9781 ttctcgttac caaagataag gtacaaatcc tttatttcta ttttactcat ataatatatt
     9841 ggtttagatt ataatatttg ttttgttttc aactgccgca ttccttattc tcacttacga
     9901 taaacaagtt gaatgttcgc atggttcagt catgtcacat gataacatga cggtccgacg
     9961 ttttttaaat ggtttaaaaa aaacagacag agtagtttaa aaggaataga atttgataag
    10021 attatcctct taatgaacag tagaaaacag tattttcata aataaataac agtctgttct
    10081 tgcatattgt tggcacaaag gtaaggaaaa tagattaaat atgcaaattt cattcaggta
    10141 cggagtaatt ccaaagatgc tttttcaagt ctacgcatcc attttgtttg aaagagatcc
    10201 cttcttccaa caagagttgt ttctgctctg tccaacccgg aacaaggcgt cccgatgcat
    10261 tgacaacccg atgacaaggc gcagataaat catccggaat ctgtttcaaa gcacgcccca
    10321 ccatacggga acattgaggc attcccaata atgcggcaat tcccccatag gtagaaactt
    10381 tacctaccgg aatttcccga acaacctgat acacctcttg acaaaaggat gcggagagac
    10441 tcgctttgtc tactttataa tctttcatca ctcaaacatt actttatttc agttccaaaa
    10501 ctagataaaa aggaaagaat ttgcaaataa taaaagtatt tcaaataaaa tatgcaactt
    10561 tatttgcttt atttacaaat aatcccgacc tttgtaccca ttaaaagcaa ccctattatt
    10621 aacaaaacaa gcactgctgt tatgaaaaag aagacaattc tattcgcttc ttgtttattt
    10681 ggagtattcg ctttcagctc ctgtgagaag aacctttatg atgaaagcaa gcaacctgaa
    10741 aaagaaattc aagtaaaaga cctggatata cccgcaggct ttcaatggaa attaactcaa
    10801 gtagccgcag gaacagtagc tgctactacc cccactatgg tttccttctt tttggatgaa
    10861 gcatgtagta aagaagagaa aatagccgac attcctgtag atacagaaat ttcaagtctc
    10921 cctttgagca tcccaaccta cgtaaataca ttgtatgccc agtacaaaac cagcaccaat
    10981 gaaaccaaaa aagtagccat acctgtaaat gcagatagaa gtttctcact gaacattgct
    11041 aatgatgcca aatccaaatc taacaccacc cggtcaatca ctcgtgggca tgatatagaa
    11101 gatgacatcc aattgtcaaa aggagtcatt tttcatccca aagatggttg gggaacaatc
    11161 atgtttgaag accaatttcc atcattagga gattatgact ttaatgattt tgtagtcaat
    11221 tataaggtgc agttccaagg tattagaaag gttgacaaaa aatacactgc gcagtatata
    11281 caaatagggt tacgtctaaa agctatcgga ggaatattcc cttattcccc ttatttaaga
    11341 ctgaaagaaa tagattctga cgaagtggaa agtatagaag tttatgaaac taaaaacgtg
    11401 attcctgcga tcgacggagt agaacttgtc cccaataaac atcttatcat tgattacagc
    11461 cctttaatta agaatctggc taaacctgca ggcagccaat attataatac agaaaagaat
    11521 gctttggtag caacaagtga tttaccggag atcaatattc tgatcaccct aaaaaagaga
    11581 aaagaagtaa aggaaatatt agaaggcgat gaattcgact tgtatttaaa acgtaatgat
    11641 agcggaacag aaatccatat gaatggtatt gaaccgatca cttaccaata tccattcaat
    11701 gataaaaatc tgctaccggt atatacaaac ggggacgaag aagatgataa ttattatttt
    11761 agtgcaggac gcctgatttg gggattaaga gtaccaggca acgcagcaca tgctattgaa
    11821 aaagctaatt tcttggaagc ctataaagga ttcgcaaaat gggcgcaaag tagtggcaaa
    11881 aacgaacaaa actggtataa tcaaggaaac gcagataaaa gtttattgat tcataactaa
    11941 cacatatcaa taaatcccgg taaacattga aaattcaagt taccgggatt tattgtattc
    12001 tgacgtgaat agttttgatt ctatcctttc cttttcagca aatctgtcgg actttcgcca
    12061 aactgctctt tatagcattt ggtaaaataa gaaggagaac taaaaccgac ttcataacca
    12121 atctccgcca ctgtcatatc cgacgaagca agcaaggaag cagctttctt caagcgagcg
    12181 atacgaagca attcattcgg agaataatta gtcaaagatt ttattttgcg atagagctgc
    12241 acacgactta atcccatatc cttacccaaa tcttctacat tcaaatttga gtctcccatc
    12301 tttgcttcaa tcaaagtctt gaatttttcc acaaagtctt tatccatatc gcaaacatcc
    12361 tctttcgcca acgtttgtcc gtcaccaaag aactgtttca ggcggcgatg tgaatctatc
    12421 agattacgaa cgcgtgccaa cagcaattgc gaactgaagg gcttggagat ataagaatcc
    12481 gcacctccgt catatccctg aatccgttgt tcatccaaag aacaggctgt caataagatg
    12541 acagggatat ggcaggtttg cagttcgctt ttcagacgac ggcaacactc tattccatca
    12601 ataccgggca tcatcacatc agagattatc aagtccggga catatttcat tgctttgcgg
    12661 atgccctccg aaccgtctgc tgcttcaatt acagtataat cggtatggag taatccgcgt
    12721 acatacgaac ggatatctgc attatcatca attaccaaaa cggaaggctt ggaagaatca
    12781 tagccttttt ccagttcctc ttcttcggca gctaaagttt cattcaggtc ggaagaggcg
    12841 ggagatccgg gagaagcagg atttaaagga actgcagaga ttgatgactt tagagaatct
    12901 tcggccagaa tagtttcaca agtctgtacc ggtaaatcaa cggtaaagac agtgccctgc
    12961 ttttcatcac tttccacaga aattgtacct ttatgcaatt caacgaaagc tttgaccaat
    13021 gcaagtccga ttcccgaacc ggcatggtgc atgtctattt tataaaaacg atcgaaaatg
    13081 ctccgaatat gttcggcgga aatcattgaa ccggtattgg caacagtaaa acgaatccag
    13141 cgagtatcct ctttcatcaa ggaagataaa cgaaccgtta tctttccatt ttccggtgtg
    13201 aacttgaacg cgttggaaag cagattaaaa taaatacgtt ccaacttttc catatccgcc
    13261 aatgtatggt aatccgtatc cggcatatta tcaaaagaga aatgaatgtg tttcttccgg
    13321 gccgctgcaa ggaatgattc gttccagccc tcaaaagagg aaagaacatc tacctgaaca
    13381 ggtgtatatt ccatcttacc gttctcgtat ttacggaaat ccagaatctg attgacaaga
    13441 cgcaagagga tattcacgtt tcgttgaatc agcatcaaca ttcgatgctg atctccactt
    13501 agtgtatgat cggccaataa atgttctacc ggatcggcaa ccaatgtaag cggagtacgg
    13561 aaatcgtgag atatatttgt gaagaacacc agtttggcat gcgttgcctc ttccagttga
    13621 tgagaaagct ggatgagctg atcccgttgc tcttccagtt tgtcccgctg ttcttctaat
    13681 tggtcgcgtt gttcctctaa cttgtcccgc tgctcttcca gctgtttctt ctgctcggaa
    13741 agttccttgt tcagacgatt tttagcacgg agagatttat agactaccaa taataagcct
    13801 gccaccaata gaagaatgac caaaccgcca tacatcacca cctgctgtgt agcaacccga
    13861 gacagatatc cgccgatacg tccgttcaat gtttcaatct tctgatccag ttccgagata
    13921 tgagtcgtct gaagttgcat gacatgcgca tttgtacggt cgaccaccgc agtgttcatg
    13981 accgtttccc ggggataagg ctttttctca aggatattca ttgccagttg catcactttg
    14041 tcgccattgg tcggataaat aaaagtagca ttcaacacac tgtcgagcac catttccaat
    14101 ccgttacctt tgccggggag agcgtcgata ccgacaaaaa tcatttcctt ctcccgtccc
    14161 actttctttg cagcctgata agctcccgga gcgatacggt cattatgcgc atacacggcg
    14221 tctatcttcg gatgccgacg gagcatacta tccatttcca cttccgccgg ttcacgctcc
    14281 cacgcagcat ccgctttatc aatcagtttg atatccggaa agttactgat agcagccata
    14341 aatccttgat ggcgttccat ggcaggagtt gagccaccca gtccggtaag ttccaccaca
    14401 ttcccttttc ctttcaggct cgacgcaata taattgccta ccgcacgtcc tatttcataa
    14461 ttgtcggcac cgatataagc agtatattta tcagaaagaa tcttccggtc taccaagatg
    14521 acaggtattc ccttttgata ggcttcctct acaatcggag tcatgggggc cgcttcgttg
    14581 gcagagataa tcaataagtc aaccccttca tctataaaat aatgaacgtc ttccgcctgt
    14641 ttacgattat catccgcagc cgaccggatt tcaaccgata ctccatcata aaacattgct
    14701 tcgcggagaa tttcatcatt catcttatgc cgccaggagt catcactaca ttgcgccacc
    14761 ccgatacgga aacgcggtgc atcctgccga caagccgtca tgccaagaag acagagcaag
    14821 actgctatcc actttgtata tcccatcatt ctaatcattc tcattttttt cgtatttctt
    14881 tctatgaccc aaatggacga ttgagaacaa aaataagaaa taaaactgtg agtatgctat
    14941 ctatcaccca attattctca tcattaccct ccaaagaaat gcaaaacagt tcccaatatt
    15001 caaccggaaa ctattaacaa aagtataaag cgtaagacaa acactcaata aatgttataa
    15061 aacatctctt tttatttgga ttatttgcag atttagcaga agtccgtatc tttgcaatgt
    15121 gtttttcata gtattagatt taaggttaac aaaggttgga gcaaggcgtt gctccttttt
    15181 ttatatccct acctctcata tcatacgaat catgcaaaaa gaaaaagagg tatattccca
    15241 cggaatgaga tatacctcta tacttacttt ccatcaaaca attacattag tctgtctttc
    15301 aaaacctgcg gaagttcggg cattgcaccg ctttgcgtgc agacataagc agaaacttca
    15361 acagcaagtt tgtgagcttc gggaaccggt tttccattca aaatggaagc acagaaagca
    15421 gccgtaaagg aatcacctgc ccccaccgta tcggcaaccg gaaccctcgg tgtctcctgg
    15481 aaagagacaa cacccggggt aaacacataa ctaccattaa ttccgcaagt cagaatcagc
    15541 atcttcaggt tgtattttgc caacaggatc caacatttat cctgtaagtc gatgccggga
    15601 tagccaaaca tacggctgat ggtcaccagt tcttcgtcgt ttatcttcag aatgttgcaa
    15661 cggcggaaag attcgcgcaa tacctctttg gtgtagaagt cctggcggag attaatatca
    15721 aagattttca gttgtccgtc tatatcgggc atcgtatcca gaaaacggtt gatagtggca
    15781 cggctcactt cattacgttg agccagggaa ccgaagcaaa cggcacgcgt actcaatgcc
    15841 aaacgtttca gttcatccgt aaaaggtatg ttatcccatg ccacaccttc tttgatttcg
    15901 taacaaggta caccctcgtt atccaatgtc acttgtaccg taccggtagg ataatccact
    15961 tgttcaatct gcgttttcag tttcttctcg ttgaatacgt tcagaatctc gtctcccaac
    16021 tcatctttgc caacggcact caccacgcga ctgtcaaaac caaactgtga tacatgatag
    16081 gcaaagtttg ccggagcacc acctattttc tttccttcgg gcaacacatc ccaaagtgcc
    16141 tcacccattc ctacgattat attattcatg atctacggat tttattgttt ccaaagttat
    16201 aaaattattt tttaatacgg aacgtataga acaagagata aagcacgccc actgtcatta
    16261 cggctactgc cccactctgt cccatggcat cggatgctac tcccatagcc aacggaaata
    16321 ccgtgccgcc gaacagtccc ataatcatca gaccggaaac ttcatttttc ttacccggca
    16381 ggtaaagcaa tgcctgcgag aagactacgg agaacacatt ggagttaccg aaaccaatca
    16441 gaccgatgca tacataaatc attgtcttgt catggaatat aaacaaacct gccatcgcta
    16501 tcagcatcat cacaacgcta atgccgaaga aagacttcgg tgacatctta cgtaaaatga
    16561 aagaaccgag gaagcagcct gccgtacgga agatgaaata aaggcttgtt gcaaaagccg
    16621 catcatcaag gcccatgccg agacgttcca tcaaaatctt gggggcagtg gtgtttgtac
    16681 ccacatcaat tccaacgtga cacatgatac cgatgaaaga aagcaggata aacggtttgc
    16741 caa
//
