LOCUS       c00343_gnlPro..        14330 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AOHAKLKG_343.
ACCESSION   c00343_gnlPro..
VERSION     c00343_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 06:52:51
            Original ID  :: gnl|Prokka|AOHAKLKG_343
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14330
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..195)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Oxidored_FMN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg343_1"
                     /sec_met_domain="Oxidored_FMN (E-value: 5.4e-09, bitscore:
                     25.2, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESKLFTPVTFGPLTLRNRTIRSAAFESMCPGNAPSDMLLDYHRS
                     VAAGGIGMTTVAYAAVTQSG"
     protocluster    1..14330
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8137:14219]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8138..14219
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14330
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14330
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(268..1038)
                     /locus_tag="ctg343_2"
                     /transl_table=11
                     /translation="MNQETFQIFLWVMSAVALVVFIALYFVKAGYGMFRTASWGISINN
                     KLAWVLMEAPVFIVMFGLWGKSGAGFAVPVYFFFLLFQLHYLQRAFIFPFLLKGKSRMP
                     VAIMAMGIVFNLLNGMMQAGGLFYFAPEGLYADGWAYLLKPHALLGIILFFAGMFINLH
                     SDYVIRHLRKPGDTKHYLPGKGLYRYVTSANYFGELVEWTGFAILTASPAAWVFVWWTF
                     ANLVPRADAIHRRYREEFGDEAVGKRKRIIPFLY"
     CDS             complement(1285..2628)
                     /locus_tag="ctg343_3"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEDLKEATRIENELFRKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVDDLAHAIIKEKRFGFEEIAYLLLSGRL
                     PDKEELSSFRELINDNMPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPDADDTSRD
                     NLMRQSIELISKFPTIIAYAYNMLRHATHGRSLHIRHPQENLSIAENFLYMLKKDYTEL
                     DARTLDLLLVLQAEHGGGNNSTFTVRVTSSTGTDTYSSIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIQDWTNVDEIDTYFTRMLNKEAYNKTGLIYGIGHAVYTISDPRAILLKEL
                     ARDLAREKGKEREFAFLELLEERAIDVFGRVKNNGKTVSSNVDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDEVTYVPIKKR"
     CDS             complement(2641..3801)
                     /locus_tag="ctg343_4"
                     /transl_table=11
                     /translation="MEKITVPFISGDGVGAEVTPSMQAVVNAAVRKSYGDRRGIEWKEV
                     LAGERAFHETGSWLPDETMEAFRTYKVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCQR
                     PVRWYKGIVSPLKEPQKVDMCVFRENTEDIYAGIEWEAGTPEAEKFYRFLHDDMGVTKV
                     RFPETSSFGVKPVSREGTERLVRAACQYALEHHLPSVTLVHKGNIMKFTEGGFKKWGYE
                     LAEREFGKELAEGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGG
                     IGIAPGANINYKTGHAIFEATHGTAPNIAGKDIVNPCSIILSAVMMLEYLGWKEASSLI
                     EKALEQSFTEARATADLARFMPGGVSLSTSTFTREIVRRIENGNNE"
     CDS             complement(3805..6048)
                     /locus_tag="ctg343_5"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDVATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVAKMAASVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASSLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNP
                     NTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGQKG
                     YIAPNKGQTEITVNPHSQRLQLLTPFPAWDGMDLLDIPLLIKVQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNVFNGETNSVWNRSTNTYGTVSGTAKLYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFTDKADYDKIRERD
                     LISVMGLKDFASGRTLKVVLHHEDGSKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             6163..8076
                     /locus_tag="ctg343_6"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRAHRGSYDEREGVRSRMSRLRDRATALEIQI
                     NAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCYEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     IGGNRILEEKIDIGIISPYKAQVQYLRSKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRTNEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRRLLEFIQNIG
                     NQ"
     CDS             complement(8138..9181)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg343_7"
                     /sec_met_domain="IlvN (E-value: 4.3e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.8e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(9232..9984)
                     /locus_tag="ctg343_8"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(9981..10541)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg343_9"
                     /sec_met_domain="ALS_ss_C (E-value: 6.7e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             complement(10574..12325)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg343_10"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.3e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(12417..14219)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg343_11"
                     /sec_met_domain="ILVD_EDD (E-value: 2.2e-219, bitscore:
                     718.8, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILAGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARLMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
ORIGIN
        1 gccgctctga gtaactgccg cataagcaac agtagtcata cctatacctc ccgccgctac
       61 cgaccgatga tagtcgagca acatgtccga cggagcgttt ccgggacaca tgctctcgaa
      121 agcagccgaa cggatggtac ggttacgcaa ggtcaacggt ccgaaagtga cgggtgtgaa
      181 taacttggat tccatcgtta tgagttatga gttatgaatt ataagttatg aattattcat
      241 tttccatttt caactttcca ttttccatta ataaagaaat ggaatgatgc gtttgcgctt
      301 tcctaccgcc tcatcgccaa actcctcccg ataacggcgg tgaatggcat cggcacgggg
      361 aacaaggttg gcaaacgtcc accagacgaa cacccaagcg gcaggggaag ctgtgagtat
      421 ggcaaacccc gtccattcca ccagctcacc gaaataattg gcagaagtga catatcggta
      481 aagtcctttt ccgggaaggt agtgcttcgt atcacccggc ttgcgcaaat gacgtatcac
      541 atagtcggaa tgcaaattga tgaacatacc cgcaaaaaac agaatgattc ccaacaaggc
      601 atgaggtttc agcaaatagg cccagccatc ggcatacaag ccttcgggag cgaaatagaa
      661 caaaccgccc gcctgcatca tcccgttcaa aaggttgaag acgataccca tcgccataat
      721 agctaccggc atccggcttt tacctttcag caggaacgga aaaataaagg cccgctgaag
      781 atagtgcaac tgaaacagca ggaagaagaa atataccggc acggcaaatc ccgctccact
      841 cttcccccac aacccaaaca tgacgatgaa taccggcgct tccataagca cccacgccaa
      901 tttattattg atggagattc cccacgaggc agtacggaac atgccataac ccgctttgac
      961 aaaatagagc gcaataaaga caaccaatgc cacagcactc attacccaca gaaatatctg
     1021 aaaagtttcc tgattcatag ttctttattt atgcgaagca aagataaaga aaactcacaa
     1081 caaacaaatc gttttccccg gataattgtt ttttcataca aaaaccagtg ttttttactg
     1141 agaagattaa gcagtagaga tacgaaaatc taatcgttcc atcatggagt aaatttcatt
     1201 ccaccatgga gaaaaaatcg ttccaccatg gtggaacgat tttttccccg tgatggaacg
     1261 atttaaaaga tacaagtcta atccttaccg tttcttaatg ggcacataag tcacctcatc
     1321 caaaacattc ttataggcag gacggataat acgcttacct tcaaagttca attcttcatt
     1381 gcgatgtgca caccaaccga caatacgtgc catagcaaac aaaggcgtga agatttcctg
     1441 cggcagtcca atcatctcgt agacaaagcc cgaatagaaa tccacattac tcgaaaccgt
     1501 cttgccatta ttcttcacac ggccaaacac atcaatggcg cgctcctcga gcagttcaag
     1561 gaaagcgaac tcgcgttctt tccctttttc gcgggcaagg tcgcgggcaa gctccttcag
     1621 cagaatggcg cgcgggtcgg aaatggtata gacggcatgt ccgataccat atatcaagcc
     1681 ggtcttgtta taggcttcct tgttgagcat gcgggtgaag taagtatcaa tctcatccac
     1741 attcgtccag tcctgaatgt tttcctgcag atggtggaac atatcggcaa cctggatatt
     1801 ggcacctcca tgaagcggcc ctttcaagga accgatacct gccgctatcg aagagtaagt
     1861 atccgtcccg gtagaagaag tgacacgtac ggtaaaagtg gagttgttac caccaccgtg
     1921 ctcggcctga agaaccagca gcaagtcgag cgtgcgggca tccagctccg tgtagtcctt
     1981 cttcagcata tagaggaaat tctcggcaat ggaaaggttt tcctgcggat ggcggatatg
     2041 caatgaacgg ccatgggtgg catggcgaag catgttatag gcatacgcaa tgatggtcgg
     2101 gaatttcgaa ataagctcaa tgctctgccg catcagatta tcgcgggaag tgtcatctgc
     2161 atcagggtca aaacgataca tctcgagcac gctgcgcgcc aggatgttca taatgttgtt
     2221 tccttcgagt tcaatgatat tcatcttggt cttctgctcc agcggcatgt tgtcgttgat
     2281 gagttcacgg aaagaagaga gttcttcctt gtcgggcagg cgaccggaaa gcaataagta
     2341 ggcaatttcc tcaaaaccga aacgcttctc tttgatgatg gcgtgtgcca agtcatccac
     2401 atcataaccg cggtagaaca atttgccggg aataggcttc agccctccac cggggatgcg
     2461 ttcatagccg accacattgc ctattttggt caaccccacc aagactcccg tgccgtcctc
     2521 attacgcaaa ccgcgcttca catcaaactt cctgaacagt tcattctcaa tccgggtagc
     2581 ttccttcaaa tcttcggaaa gcttgtaaat cagatactcc ttcttcataa tcgtttcgtt
     2641 ttattcgtta ttcccatttt ctattctcct tacaatctcc cgggtgaaag tcgaagtgga
     2701 cagcgagacg ccacccggca taaaacgggc caagtcggca gtagcacggg cttctgtgaa
     2761 actttgttcc aaagctttct ctataagaga ggatgcttcc ttccaaccca gatattcaag
     2821 catcatcaca gcggaaagga tgatggaaca gggattcaca atgtctttcc cggcaatgtt
     2881 cggagccgtc ccgtgagtag cctcaaaaat ggcatgcccc gttttatagt tgatattcgc
     2941 acccggtgca atgccgatgc cgcctaccat ggcagccagt tggtcggaca cataatcgcc
     3001 gttcagattc aacgtggcaa tcacggaata ttcttcgggg ataagcaacg tgttctgcaa
     3061 gaatgcatcg gcaatgcagt ccttgatgac cagacgccct tctgccagtt ctttaccaaa
     3121 ctcacgttct gccagttcgt acccccactt cttgaagccg ccttccgtaa atttcatgat
     3181 gtttcctttg tgtaccaacg tcacggaagg cagatgatgc tcaagggcgt attggcaggc
     3241 ggcacgcacc aagcgctctg ttccttctct tgaaacgggc ttcacgccaa acgaggaggt
     3301 ttcgggaaaa cggacttttg tcacccccat gtcatcatgg agaaaacgat agaacttttc
     3361 agcctccgga gttccggctt cccattcgat gcctgcataa atatcctcgg tattctcacg
     3421 gaatacgcac atatccacct tctgcggctc tttgagtgga gaaacaatgc ccttatacca
     3481 acgtaccgga cgttggcaga catacaaatc aagcgtctga cgcaaggcta cgttcaagga
     3541 acggatacct ccgccgacgg gagttgtcaa aggacctttg atgcccacct tataggtgcg
     3601 gaaggcttcc atggtttcgt ccggcaacca ggaaccggtt tcgtggaagg cacgttctcc
     3661 tgccagcact tctttccatt caatgccacg ccggtcacca taggatttcc tgacagcggc
     3721 attcacgaca gcctgcatgg atggggtcac ttctgctccc actccatcgc cggaaataaa
     3781 aggtacagta attttttcca tattctatct tgcattaagt gcagaaccgg cccggaacca
     3841 ggctatctgc tgttcgttat acgtatgttg tacttcaaaa ctttctttac tcccgtcctc
     3901 gtgatgaaga accaccttca acgtgcgtcc cgaagcaaaa tctttcagcc ccatgacaga
     3961 aatcaggtcg cgttcccgaa tcttgtcata atcggcctta tccgtaaagg tcagcgccag
     4021 catgccttgt ttctttaaat tcgtctcatg gatacgggca aagcttttcg ccaaaatgac
     4081 gcgtacattc aagaagcgtg gttccatggc agcatgctca cggctggacc cttcaccata
     4141 attctcttcg gcaacgacaa tggaagggat accttcggat ttatacaatt tcgccgtgcc
     4201 tgacaccgtt ccataggtat tggtagagcg attccagaca ctattcgtct ctccattgaa
     4261 aacattgaca gcccccatca gcatattgtc cgaaatattc tccaaatgtc cccggaaacg
     4321 tagccatggc cctgccatgg aaatgtggtc ggtggtacat ttcccctgta ctttaatcaa
     4381 taaaggtatg tccagcaaat ccatgccatc ccaggcaggg aagggagtca gcagttgcaa
     4441 gcgctgtgaa tgaggattga ccgtaatttc cgtctgtccc ttgtttggag caatatatcc
     4501 tttttgtcct ccgatgaatc cgtgtgccgg caattcctca ccgaccggtt cggacagttt
     4561 cacaacctct cctttggcat tgaccagcgt atcccgcaag gggtcgaaac agaggtcgcc
     4621 tgcaatggtc agtgccatcg ttatctccgg ggaagcgacg taagcaaaag tattgggatt
     4681 tccatcggca cgtttggcaa aattacggtt aaaagaggtg acgatggaat tttttcgttc
     4741 agggtcatca gtatggcgct tccactggcc aatacaaggt ccgcaggcat tcgccattat
     4801 cgttgcgcca atatcttcga aagcggcaat catgccgtcg cgttcagcag tggcacgtat
     4861 ctgctccgaa ccggggttga caatcagcga ggaagcaacc ttcaaattct tttcctttac
     4921 ctgccgggca agggaggctg cgcggctcaa atcctgatag gacgaattgg tgcacgaccc
     4981 tatcaggccg acttccatcc ggcggggata gttattggtt atcactacct cggcaaattt
     5041 cgatatcggt gttgctgcat ccggcgtaaa gggcccgttg atatacggtt ccaacagcga
     5101 gaggtctatt tcaatgatgc ggtcgtaata tttttccgga tttgccagca cttcgtcgtc
     5161 ggcgcgaagg tcggcagcta cggaagcagc catttttgcc acttcttcac gtccggtagc
     5221 cttcaaataa gtacccatgc gctcatcgta agggaaaagg gaggtagtcg cccccacctc
     5281 tgcccccata ttgcagatgg tagcctttcc agtggcagac aatgaagcgg ttcccggtcc
     5341 aaaatattca atgatggcat tggttccccc ttttacagta agaatacccg ccaacttcag
     5401 aataacatct ttgggagcta cccagccact caatttaccc ttcaaatgta cgcctatcag
     5461 acgcggcatt ttcaattccc attccatgcc agtcatcaca tccaccgcat cggcaccacc
     5521 cacaccaatg gccaccatgc ccaaacctcc ggcattgggc gtatgagagt ccgtgcctac
     5581 catcattcca cccggaaatg cgtagttctc caataccacc tggtgaataa tgcctgctcc
     5641 cggctgccaa aaacctatgc catagcggga agaaacatca cggagaaaat tatagacctc
     5701 ctcgttggtc ttcgtagcag tcgcaacatc ttcttttgca cctttatatg cttgaatcaa
     5761 atggtcacag tgcacagtgg aaggcacggc aacctgctca cggcctgcat tcataaattg
     5821 caataaggcc atttgagccg ttgcatcctg catggccaca cggtcgggac ggaaattcac
     5881 atagtcttct ccccgtctgt agttcttcac tttatcccca tcatacaaat gagcatacaa
     5941 aattttctct gctaaagtca tcggacgccg cagtacgttc cgtacgcgtt ctatcttctc
     6001 cgaataagcg gcataaaacg ttttgagcat cgttaaatca tataccataa ccactatttt
     6061 ttagtttttc attattgtaa agattacaaa ttaatatcat aaacaaataa aaaggctgaa
     6121 tagtttaaca aaataaagca ttttttctgt cggaagcgaa gaatgattac ctttgcaacc
     6181 atgaaggaac aagattcaaa tagtcctatt attcacctcc agcagcaaca acttttgctg
     6241 cgcatggaat acgaatacga aaaagaggaa ttcaaacgcc aaaccgaaaa catgggggtt
     6301 gcccggaaag tgaaacgggg actttgctgg tatcctgcca ctccgggacg aagttactat
     6361 aattcactga atcaattagt aatagaaatt acacacacag aaaataccga tatagaacat
     6421 aattttgagt tcggccgtcc cgtatgtttt ttccgccagt ctgccgatgg aaaaataacc
     6481 tatatgaact tcaccgctac cgtaagctat gccgacgaga cacggatggt agcgataatg
     6541 cccggagccg gtgccgtgat ggaagtgcag gaaacggaca acctcggcgt gcaactttat
     6601 ttcgacgaaa catcctatcg gaccatgttc gaagccttgg aagatacgtt acgctccaaa
     6661 ggcaaccgcc tggccgaatt gcgggacata ttgctgggaa cctcgaaagc cggtttccga
     6721 gagctctatc ccgtacggtt tccctggctg aactccacgc aggaaacagc tgtaaacaaa
     6781 gtgctgtgtg ctcgcgacgt ggccattgta catggtcctc caggaaccgg aaaaacgacc
     6841 accttagtgg aagccatcta cgaaaccctg catcgggaac cgcaggtact ggtatgtgcc
     6901 caaagcaata ctgccgtcga ctggatttcg gaaaaacttg tggaccgtgg cgtcaatgtc
     6961 ctgcgtatcg gcaatccgac ccgtgtcaac gacaagatgc tttcctttac ctacgagcgt
     7021 cgtttcgaga accatccgct ttatccggag ctgtggagca tccggaaaaa tctccgtgaa
     7081 ctgggcagcc gtgcccaccg tggcagctat gacgaacgcg aaggagtacg cagccgtatg
     7141 agccgcctgc gcgaccgcgc caccgcattg gaaatacaaa tcaatgcaga gctttttgat
     7201 ggggcacatg tcatagcctc cacgctagta agcagcaatc accggctgct gaacggacgc
     7261 cgtttcggca cccttttcat tgatgaagca gcccaggcct tagaagctgc ctgctggata
     7321 gctatccgaa aagcagaccg cgtggtgttg gcgggtgacc actgccaact tccgcccacc
     7381 ataaaatgct acgaagctgc ccgtggaggt ctggaacgaa cattgatgga gaaagtggtg
     7441 tccaacaaac ctgccgttgt ctctttgctg aaagtgcaat accgcatgca cgaggaaatc
     7501 atgaaatttc cttcccaatg gttttataat ggcgagttgg aagccgctcc cgaagtacgt
     7561 taccggggca tcctggactg ggataccccc atccactgga ttgacacctc cgaaatggat
     7621 ttcaaagaag aatttgtggg agagactttc ggacgcatta ataaggcgga agcggacctg
     7681 ctcctatcag aactgaaaat ctacatcaac cgtatcggtg gcaaccgcat tctggaagaa
     7741 aaaatagaca tcggcatcat ctccccttac aaggcacaag tgcaatatct ccgcagcaag
     7801 ataaaggcag acgcttcact caagccttat cgcagcttgt tcactgtaaa tacggtggat
     7861 ggcttccaag ggcaagagcg cgatgttatc ttcatcagcc ttgtccgtac caacgaagaa
     7921 ggacagatag gattcctgaa tgatttaagg agaatgaatg tagccatcac ccgggcacgt
     7981 atgaagctgg tgatattggg agaggcagag acgctgaaac atcacggttt ttaccggagg
     8041 ctattggagt ttattcaaaa tatagggaat caataataaa gaaatacccc ctccggtaac
     8101 accgaagagg gtatttcacc tatttatata aagctgatta attgttttcc ggacgaagtt
     8161 tacgaactgt aacagctgtc tgccacattt cgctttcacg caaggctttc aattctgcat
     8221 tcagcttctc acgataatcg ggtttggagt tactgtcgat agaaatctgg gcttcgttgc
     8281 ccgacttcac acttgcatac aatttctgta caaccggctt gatggcatca tggaacgggg
     8341 tcatccaatc cagcgcacca cgctgtgccg tagtagaaca gttggcatac atccagtcca
     8401 taccgttctt ggcaaacaat ggcatcaaag attgagtcaa ctcttccact gtttcattga
     8461 atgcttcaga aggagtatgg ccgttttcgc gcaatacttc atactgagcc aacagtaatc
     8521 cctggatagc acccatcaat gaaccgcgtt caccggtcaa gtcggaagtg gcttcgcgga
     8581 tgaaagttgt ctcgaacaaa tatcccgaac cgataccgat acccagtgca atcgtcttgt
     8641 caaaagcctt acccgtagca tcttgataga cggcatatga tgagttcaag ccacgccctt
     8701 cgaggaacat ggtacgaagt gaagtaccgg aacctttggg agcaaccata ataacatcaa
     8761 tatctttagg aggaaccacg ccggtacggt cgttccaggt aatagcaaaa ccatgagaga
     8821 agtaaagagc cttcccggga gtcaaataag gtttgatagt cggccataca gacattacag
     8881 ctgcgtcaga caacagacac atgacgatag tacctttctg acaagcctct tcgatgccga
     8941 acaaagtctc acccggtacc catccgtcag ccacagcctt ttcgtatgtc ttacccggac
     9001 gttgtcctac aatcacattg aaaccgttat cacgcaagtt gcaagcctgg cccgggcctt
     9061 gtacgccata accgattact gcaattgttt catctttcaa aatctcacgt gctttttcca
     9121 aaggaaattc ttcgcgggtc attacattct caataacacc gccaaaattc aattgtgcca
     9181 ttttttgttt taatttttat ttgtggctta cgccaacgtt gataaattta tttatttctc
     9241 tgtaaatatc actttagagc gacagaccac ttcgctgcca ttctttttca cctccacatc
     9301 gtaaacgccc tcaccggcat catccatgaa caaagtcaac tcatccccat aatagctttc
     9361 ggctacatat gccatttcaa aacgacggat gcgcttctcc ttatacatct ctatcgggaa
     9421 caaatcaagg atatgctcga tgtaacggat gctgttcaca tgcccgttaa tgtcaatatc
     9481 actgtatttg gctaccaaag cagcaaccgg ttcctttgag gccaccttta tccgcgaagg
     9541 tttttctatc ggacaaggct catcacaaac ataatctaca atgctgccac tatgaagagc
     9601 cagcaaatct gccggcttac gggtattcat gctaatcatc gcccaaacgg aacgtgcata
     9661 cccaatcttc ttaccctcct tatcgatgat agcgaaatta cggtctgtaa aaaggcgata
     9721 gacattctcc acccaagtct gaatggagaa atcttcgtac tgataaggca tttcatccag
     9781 ttcgacagcc agacgggaca atacccaagt ataattgtcc tcgtttagag tcgcgatgcc
     9841 aaaaccgcgg tcgctggcat ggaaacccgc acaattcaac aaatggttgc ccaatactcc
     9901 cattgtcagc cgtccggtaa agtcgacatg aaacggttcg gcaacaaact tgtaggtacc
     9961 tattttattg ttctcgctca tcatgattcc tggtgtttac tttgacgata ttttgcttca
    10021 cggtccgcca gatattcatt gacacgctca aagcagctgg tcgtaatggc tacgcgaccc
    10081 gaacggacga actgaagtac gcaatccaac tggcgcaact cctcataaag attggttatt
    10141 tcctcactca tgccattctt ctcaacaatg gcaaatacag cattcacctc cacaatacgg
    10201 gcattgtact tacggattac tttggacacc tccggttttt cttccagcgt aggggtcgtt
    10261 attttataga gagcaatctc gtgctgatag atttcatcat ccgtaaaata atgggcttgc
    10321 agcacatcta ttttcttggt aatctgcttg gtcacctttt caatggtatc cttgtccgtc
    10381 caagcggtaa tggtatattt atgtaccccc ttgatggagg aggccgatac attcaaactc
    10441 tcgatgttta tctgccggcg ggtaaacaca gccgtcacct gattcagcaa accggcaaag
    10501 ttttccgaat gaacaatgat tgtatatagt tttttatcca tagatagagt aaattcttta
    10561 atttcgcatg acttcagcat tccaacaaca tctgattgac cgaaccgccc ggaggtgtca
    10621 tcggcattac atttccttct tcctccacac aagcttcgag caggaacggt ccgtcggttg
    10681 ctatcatctc gtcaatcgct tttgccagct cctcgcgggt cattaccctg cgtgcaggaa
    10741 tatcatatgc cgaagcaatc ttcatataat ccggattcat catcggagta aacgaataac
    10801 gacgattgaa gaacatcgcc tgccattgac gaacattgcc caagaagtta ttgttcaaca
    10861 gaatcatctt caccggagcc ttttgttcca tgatggtacc cagttcctgc aggttcatct
    10921 gcaagccgcc gtctcccatg aatacgcata ccgtgcggtc cggacgtcca aaagtggcac
    10981 cgatagctgc cggaaggccg aagcccatag tacccaggcc accggaagta acaatgctac
    11041 gttccttgct gtatttgaaa taacgggcgg acatcatctg attctggccg acatcagtca
    11101 ccaatatcgc ctcgttatgg gtagcctcac tcacagcacg caccacctca cccatgctta
    11161 gcgcttttcc tgccggatgt aattccggac ggattacctt ttcctcttcc acttcctcgt
    11221 attgccggaa actgtcaatc cattcctgat ggttggcggg ttccagcaat tgggtaacgg
    11281 cagccagtgt ctctttgcaa tcgcccagga cagcaacatc ggtctttaca ttcttatcta
    11341 tttcggcagg gtcaatatca aagtggataa tcttcgcctg cttggcatat gtttccaatt
    11401 tacccgtcac acggtcatca aagcgcatgc ctacggcgat aaggacatca catttattgg
    11461 tattgatatt gggccccagg ttaccgtgca taccaagcat tcctttgttc aacggatggt
    11521 tcgtaggtaa tgcggaaagt cccaataaag tgcatccggc aggcattccg gctttctcaa
    11581 tgaaagcacg aagctcttgc tgggcttctc ccagctccac gccttgtcct accagcacca
    11641 aaggccgttc cgcaccattt attaattcag cagccttccg tatggcctcc ggctccattt
    11701 cgggaacggg aagatagcta cggacatagt ccaccttagt aggcgcatat tctgttttct
    11761 ccacttgggc gtttttagca aaatccagca cgaccggtcc cggacgtccg ctctttgcca
    11821 catagaaagc acgtgccact gcccaggcca catcttctgc acgacgaatc tggtaactcc
    11881 atttcgtgat aggctgagta atgcctacca agtccacttc ctgaaatgca tccgtaccca
    11941 agaagttcgt ccctacctgg ccggcaatga caacgatagg cgtactgtca atcatggcat
    12001 ctgcaatgcc cgtgatagta ttggtagcac ccggtccact ggtaaccaga caaacgccaa
    12061 cctcgcctga tacacgtgca aagccttgtg ccgcatgggt tgctccttgt tcatggcgaa
    12121 ccaagatgtg gttcaattcc ttccggtggt cgtataaggc atcgaatacc ggcatgatgc
    12181 tccctcccgg ataaccgaaa atggtcttta ctccctgatg ctccagagag cgcatcaatg
    12241 cttctgcgcc tgttattaga gcctcacccc gaccctctcc ttgggagagg gaggaaaagt
    12301 tactcttttt attattatca gccatacttt atctattcat tatatttaaa agctcaatag
    12361 tagcttgaaa aatttgtttc attctctcct cccctcgctt tcggaaaggg gggcttttaa
    12421 tcaatcagcc tcacagcccc tttgtcagcg gaactcacca tactggcata tgctttcaat
    12481 gctttggaga cttcacggtt gcgggttacc ggagtcataa ggcgtgctgc aagctcttca
    12541 tccgtcaact tcacattgat agaacggttc ggtatatcaa tttcgataat gtccccatcc
    12601 ttaatcttgc cgatattacc accggcagcc gcttcgggag aaacatgtcc gatacttagt
    12661 ccggaagtac caccactgaa acgcccgtcg gtaatcaatg cacactcctt acccagatgg
    12721 cgggatttga tataagaagt aggataaagc atctcttgca tacccggtcc acctttcggc
    12781 ccttcgtgag tgatgacgac gacgtctcca ctgaccacct ttccagccag aataccgtca
    12841 caagccgcat cttgtgagtc gaagactttc gccggccccg taaatttcca gatactctcg
    12901 tctacaccgg cagtcttgac aacgcaaccg tcctgagcta tatttccctt caaaactgcc
    12961 agaccgccat ccttgctgta tgcatgttcc aaatcacgga tacaaccggt cgcacggtcc
    13021 gtatcgagtt ccttataaga cgcattttgt gagccgagta ccagattgaa ctttccggct
    13081 gccgcactgg agtatttctt gattgcctct ttacatacat tagagctggt aatactatac
    13141 cggtcgattg cctctgccaa cgtcattcca tccacacggc ggacattcgt atcgaccaat
    13201 ccgcccttgg caagctcatc catgatggca atgatgccac cggcacggtt aacgtcttgt
    13261 acatgatact tttgggtatt gggagccacc ttgcataagc agggggtctt gcgggagagc
    13321 atgtcaatat cgtccatctt aaaatccgct ccggcttcgt gagccacagc caacaaatga
    13381 agtaccgtat tagtggaacc gcccatcgca atatccagcg tcatggcatt caaaaatgcc
    13441 tcgcgggtag caatactgcg cgggagtaca ctctcatccc cttcttcata atatctaaag
    13501 gcattctcta caatcaacct ggctgcatcc tcaaatagtt tcttgcgatt ttcgtgagtg
    13561 gctacaatcg tgccgttacc gggcagtgcc aatccaatcg cttcattcaa gcaattcatg
    13621 gaattagcgg taaacatgcc tgagcagcat ccgcaagtgg ggcaggcatg ttgctcaatc
    13681 tgtgccacct ctttatcgcc cacactttca tcagcagatt taatcatggc atcaatcaaa
    13741 tccaaatgct gtccgttcca ttccccggct tccatcggac cgcctgaaac aaacacagtc
    13801 ggtatattca gcctcatagc cgccatcagc atccccggag taatcttgtc acagttactg
    13861 atgcaaacca tagcatctgc cttatgggca tttaccatat actccacact atcggcaatg
    13921 atatctcttg aaggcaggga ataaagcata ccgtcgtgtc ccatagcgat accgtcgtca
    13981 atggcaatcg tattgaactc cgcagcaaaa caccccagtt tttcaatctc ttcctttaca
    14041 aactggccta tttcgtgcag gtgtacatgc ccggggacga attgtgtaaa tgaattgact
    14101 atagcgataa tgggcttacc catctgttcc ttcttcatac cattcgccgt ccacaatgca
    14161 cgggctcccg ccatgcggcg accttgtgtg ctgaacgagc tgcgtaactg atgcttcatt
    14221 ttcaaatctc cttttaatga aaaagcctct cccactatag tgagaaaggc ttaataaatt
    14281 atcttctaac gtacgaatac atacataacc tttctcacgc tcttgatgcc
//
