LOCUS       gnlProkkaNIILIAEK_186  15690 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NIILIAEK_186.
ACCESSION   gnlProkkaNIILIAEK_186
VERSION     gnlProkkaNIILIAEK_186
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 01:05:10
            Original ID  :: gnl|Prokka|NIILIAEK_186
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15690
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15690
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5336:5690]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5337..5690
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15690
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15690
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2..2980
                     /locus_tag="ctg186_1"
                     /transl_table=11
                     /translation="MVLEDIFSKRKTLRTIKADTSDYFIPLFHTLAVFLSTKETIITKR
                     FLEHIMKNLIALTLLLGGSTLLCAQKPAKTPATYKPVKSEMYRKGWIDFNKNGVKDVYE
                     DPSAPLEARIENLLQQMTLDEKTCQMVTLYGYKRVLKDDLPTPEWKELLWKDGIGAIDE
                     HLNGFQQWGLPPSDNAYVWPASRHAWALNEVQRFFVEDTRLGIPVDFTNEGIRGVESYR
                     ATNFPTQLGLGHTWNRELIRQVGLITGREARMLGYTNVYAPILDVGRDQRWGRYEEVYG
                     ESPYLVAELGIEMVRGLQHNHQVAATGKHFAAYSNNKGAREGMARVDPQMSPREVENIH
                     IYPFKRVIREAGMLGVMSSYNDYDGIPVQGSYYWLTTRLRGEMGFRGYVVSDSDAVEYL
                     YTKHGTAKDMKEAVRQSVEAGLNVRCTFRSPDSFVLPLRELVKEGGLSEEVINDRVRDI
                     LRVKFLIGLFDAPYQTDLAGADREVEKEENEAIALQASHESVVLLKNADELLPLDINST
                     KKIAVCGPNANEEGYALTHYGPLAVEVTTVLEGIQEKTKSKAEVLYTKGCDLVDAHWPE
                     SEIIDYPLTDDEQAEIDKAVENARQADVAVVVLGGGQRTCGENKSRTSLDLPGRQLQLL
                     QAIQATGKPVVLILINGRPLSINWADKFVPAILEAWYPGSKGGTALADILFGDYNPGGK
                     LTVTFPKTVGQIPFNFPCKPSSQIDGGKNPGPTGNMSRINGALYPFGYGLSYTTFEYSD
                     LDITPRVITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTYEKNRAGFQRIHLE
                     PGEAQELSFTIDRKHLELLDADMKWVVEPGDFVLMAGASSEDIRLNGTLTVEDYQTRAK
                     AIEAQKPAKRVSASTNPEDAENVLDEKINTAWQGNKGDYITFALKNGTQVDKVTIAFTR
                     DNNLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVLNDDRVSIAE
                     VKF"
     CDS             3082..4209
                     /locus_tag="ctg186_2"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGDQDELAMLIGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSAALPNPSYLVPSEDGEFVYAVSEMNDSTAALSSLALDRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQATPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDDPIPHASLEAVDIEADSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGCLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKEDGIAIFAVNPENGTLAKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             4280..5329
                     /locus_tag="ctg186_3"
                     /transl_table=11
                     /translation="MKKNILMLSALFLSITAMAQTDVTTGVMRGKDYGVTYMLPKTEIE
                     IVLQATKHTYTPGEFCRYADRYLRLNNVSAEPEEFWTLDKIETRIAGVPDKDNVYFVKM
                     KDKTVAPLMELTEDGIVRSINIPFSGKPAAKTPEAKATESSIDPRSFLTEEILMSNSSA
                     KMAELVAKEIYSIRESKNALLRGEADNMPKDGAQLKLMLDNLNQQETAMTEMFSGKIKK
                     EPKTFTIRLTPKEMKDEVAFRFSRKLGVVANNDLAGEPYYISVTDLKSPDVSATEEGKK
                     KVDGVAYNLPGKAQVTLVYNNKKLFDDQLPITQFGTVEYLAPVLFNKNSTIKVLFDTAT
                     GGLIKVDRE"
     CDS             complement(5337..5690)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_4"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-10, bitscore:
                     30.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-17, bitscore: 53.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEIPEGKVSLLDAVPVRCGHITTEWEGECAVLAYPRFKYEWMRR
                     FLLPKGMSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLARHFGEEENYIPRVTAYVMQ
                     LRKDGFIQLTIRN"
     CDS             complement(5710..7101)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 100.6; E-value: 1.2e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg186_5"
                     /transl_table=11
                     /translation="MTEQLKLKLNDSKATRWGALVIVAFTMMAAYYVNDVVAPLKTMLE
                     TDLAWSSTDFGFFTGGYSFLNVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYY
                     AMTGLAGADATLFGINEIFGYKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKEL
                     ATAMGVQVALARIGSQAGYAVAIPLARAFGISTPVLLGLVLLLGGMIAFFIFAVMDKKL
                     DKQMEAAAIAAGTEDEEEKFSFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELM
                     IIKYGINENVAGTFAGLPALGALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAI
                     PDINYWLVAIVLMIILGIAFSLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIP
                     TLIGWVLDAYCISGKKPDGTNMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEE
                     PNIQK"
     CDS             complement(7255..7644)
                     /locus_tag="ctg186_6"
                     /transl_table=11
                     /translation="MYLLLVILMLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEA
                     PQSEAPAATTPAEAPAPAAEAPAAE"
     CDS             complement(7649..8422)
                     /locus_tag="ctg186_7"
                     /transl_table=11
                     /translation="MTPTHLQQWIQHPETLNRDTLYELRTLVARYPYFQSLRLLYLKNL
                     YLLHDINFGAELRKAVLYVADRRVLFYFIEGDRYTLKSRKVSSLFSGDLEKEPSVDRTL
                     SLIDAFLATVPEEHSQHTELDYAVDYTAYLMQEEPGVDAEDESEVPKLRGHELIDDFIQ
                     KSESSDASDTRREFLVEKEEETEEEEEPSVSPVTEELDDSCFTETLAKIYIKQHRYDKA
                     LEIIKKLSLNYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             complement(8427..8951)
                     /locus_tag="ctg186_8"
                     /transl_table=11
                     /translation="MDWIKKAAFASLLVSLLFLVNSCSMKLGLAPISSIDYTKVKTISI
                     ADFQNRAEYVYAPLATEFNQKMKDMFIQQTRLQLVNSGGDLEIDGEITGYNQYNESVDA
                     SGYSSKVKVTLTVNVRYTNNTNHEEDFEQQFSAFQTYDSSKLLTEVQDQLITLMVKDIA
                     EQIFNATVANW"
     CDS             complement(8938..10188)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 380.4; E-value:
                     2.1e-115)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg186_9"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNNEALMRAIDIAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EANGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVEKTDVRIVAATNVNLTQAI
                     ADGRFREDLYYRLNTVPIQVPPLRERGEDVVLLFRKFASDFAEKYRMPAIQLTEDGKQV
                     LLGYSWPGNVRQLKNITEQISIIETNREINASILKGYLPEQNNMQRLPALFGVKEDKSF
                     GSEREILYQVLFDMRQDVTDLKKLVHEIMAERGTVANPAVATSAYYTPATPAVVPPVTS
                     SVPTIIHPSAKPVTPVDDDFQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAQDL
                     NISERTLYRKIKEYGLD"
     CDS             complement(10190..11287)
                     /locus_tag="ctg186_10"
                     /transl_table=11
                     /translation="MEDNKIRVGITQGDINGVGYEVILKTFADPVMLELCTPIIYGSPK
                     VAAYHRKSLDLSTNFSIVNSASEAVPNRLSVVNCTDDEVKVEFSKPDVEAGKAALGALE
                     KAIEEYKEGMIDVIVTAPINKHTIQSEEFAFPGHTEYIEQKLGDGEKALMILMKDDFRV
                     ALVTGHIPVKEIAGSITKELIQEKLKIFNRSLKQDFAISAPRIAVLSLNPHAGDGGLLG
                     TEEQEIIIPAINEMAAKGMLCYGPYPADGFMGSDNFTHFDGILAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGIASEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDSVEEDL"
     CDS             complement(11293..12348)
                     /locus_tag="ctg186_11"
                     /transl_table=11
                     /translation="MRKHLFYLSMVLVLTLFSACGGGKKGVFTPTSSGRAYEVLVVVEP
                     GLWERPAGRALFDVLDSDVPGLPQSERSFRIMYTAPSNYDATLKLIRNIIIVDVNKDLY
                     TQPKFKYARNVYAAPQSILTIQAPDEASFEKFVEENRQVIIDFFTHAEMNRQISVLKDK
                     HSDYIATKVKSLFDCDVWVPGELTSTKEGENFFWAGTNAATGDQNFVIYSYPYTDKDTF
                     TKEYFVHKRDSVMKANIPGAREGMYMSTDSLMTDVRPISVQGDYALEARGLWRIKGDFM
                     GGPFVSHVRLDKANQRIIVSEIFIYSPDKMKRNLVRQMEASLYTLKLPGSKLEGAEIPV
                     GVTAKDTTNNK"
     CDS             complement(12419..13459)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg186_12"
                     /sec_met_domain="PF04055 (E-value: 2.2e-17, bitscore: 53.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKRPLLGLTLSELQNVVKNLGMPGFSAKQIASWLYDKKVTSIDE
                     MSNLSLKHRELLKEIYEVGAEAPVDAMRSVDGTVKYLYRAGEGHFVEAVYIPDEDRATL
                     CVSSQVGCKMNCKFCMTGKQGFTANLTSNQIINQINSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALEIMTASYGYAWSPKRVTLSSVGLKKGLQRFIEESDCHLAISLHSPIPLQRRE
                     LMPAEKAFSITEIVELLRNYDFSKQRRLSFEYIVFKGVNDSLPYAKELLKLLRGLDCRI
                     NLIRFHAIPGVNLEGADMETMTAFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEE
                     NKEELI"
ORIGIN
        1 tagcgtcttg gaggatattt ttagtaagag gaagaccctt cggacaataa aagccgatac
       61 ttcggactat tttatccctt tatttcacac attagccgta tttttgtcaa caaaagaaac
      121 aataataacc aagagatttt tagaacatat catgaagaac cttattgccc taaccctgct
      181 gcttggagga agcacactgc tctgcgcaca aaagcctgcc aaaacaccgg caacctacaa
      241 gccggtgaaa agtgaaatgt accgcaaagg ttggatagac ttcaacaaaa acggagtgaa
      301 agacgtgtac gaagacccct ccgccccgct cgaagcacgc atcgaaaacc tgctgcaaca
      361 gatgacgctg gacgaaaaga cctgccaaat ggtcaccctc tacggctaca aacgcgtact
      421 gaaagacgac ctccccaccc ccgaatggaa agagctgctc tggaaagacg gcatcggcgc
      481 catcgacgaa cacctgaacg gcttccagca atgggggctg cctccctcgg acaatgccta
      541 cgtctggccc gcctcgcgcc acgcctgggc actgaacgag gtgcaacggt tctttgtgga
      601 agatacccgt ctcggcatcc ccgtagactt taccaacgaa ggcatacgcg gcgtggaaag
      661 ctaccgcgcc accaacttcc ccacccaact gggactggga catacctgga accgtgaact
      721 gattcgccaa gtaggactca tcaccggacg cgaagcccgc atgctgggct acaccaacgt
      781 ctacgccccc atcctcgacg taggacgcga ccagcgctgg ggacgctacg aagaagttta
      841 cggcgaatct ccctacctcg tagccgaact gggcatcgaa atggtgcgcg gcttgcagca
      901 caaccaccaa gtggccgcca ccggcaagca ctttgccgct tacagtaaca acaaaggcgc
      961 ccgcgaaggc atggcacgcg tggacccgca aatgtcgccg cgcgaagtgg agaacataca
     1021 catctacccc ttcaaacgcg tcatccggga agctggcatg ctgggcgtaa tgagttcgta
     1081 caacgattac gacggcatcc ccgtgcaggg cagctactac tggctcacca cccgcctgcg
     1141 tggcgaaatg ggattccgtg gctacgtcgt atccgacagt gacgccgtag aatacctcta
     1201 caccaagcac ggcaccgcca aagacatgaa agaagccgtc cgccaaagcg tggaagccgg
     1261 gctgaacgta cgctgtacct tccgctcgcc cgactccttc gtccttcccc tccgcgaact
     1321 ggtgaaggaa ggcgggctga gcgaagaagt cattaacgac cgtgtgcgcg acatcctccg
     1381 ggtaaagttc ctcattggtc tgttcgatgc cccctaccag acagaccttg ccggtgccga
     1441 ccgtgaagtg gaaaaagaag agaacgaagc catcgccttg caggcatccc acgagtccgt
     1501 cgttctgctg aagaatgccg atgagctgtt gcccttagac atcaactcca ccaagaagat
     1561 tgccgtctgt ggtcccaatg ccaatgaaga aggctacgcg ctgacccatt acggcccact
     1621 tgccgtagaa gtgaccactg tactggaagg cattcaagaa aagacaaaaa gcaaggcaga
     1681 ggtgctctac accaaaggct gcgacctagt ggatgcccac tggcccgaaa gtgaaatcat
     1741 agactatcct ctgaccgacg acgagcaagc cgagatagac aaagccgtag aaaatgcccg
     1801 ccaagctgat gttgccgtcg tagtattggg cggcggacaa cgcacctgcg gcgaaaacaa
     1861 atcgcgcacc agcctcgacc tgcccggccg gcagttgcaa ctgcttcaag ccatacaagc
     1921 cacgggcaag cccgtcgtac tgatactcat caacggacgc ccgctctcca tcaactgggc
     1981 agacaagttc gtccccgcta tcctcgaagc ctggtatccc ggctccaaag gcggaacagc
     2041 cctggccgac atcctcttcg gcgactacaa ccccggtgga aagctgacgg tgaccttccc
     2101 caagaccgta gggcaaatcc ccttcaactt cccctgcaaa ccttcttcac agatagacgg
     2161 cggtaagaat ccgggaccta cgggcaacat gtcacgcatc aacggagcac tctacccctt
     2221 cggttacggc ttgagctaca ccaccttcga gtactccgac ctcgacatca ccccccgagt
     2281 catcaccccg aacgagtctg ccaccgtccg cctgaaggtg accaacaccg gcaaacgtgc
     2341 cggagatgaa gtagtgcagc tctatatccg cgacgtactg agcagcatca ccacctacga
     2401 aaagaatcgt gcaggcttcc agcgcatcca cctcgaaccg ggcgaagccc aggagctgtc
     2461 cttcaccatc gaccgcaagc acctggagct tctggacgcc gacatgaaat gggtggtgga
     2521 acccggcgac ttcgtgctca tggccggcgc ctcttccgaa gacatccgcc tgaacggaac
     2581 gctgaccgta gaagactacc agacccgtgc caaagccatt gaagcccaaa aaccagcaaa
     2641 gcgtgtgagt gccagcacca acccagagga tgccgaaaac gtgctcgacg aaaaaatcaa
     2701 taccgcatgg caaggaaata agggagatta tattaccttt gccttgaaga acggaaccca
     2761 ggtagataaa gttaccatcg cctttacacg tgacaacaac ctgccggcaa ccttcgaaat
     2821 ccagctctcg ggcggtggcg gacagttcct caccgtatat tcgggcaccg tcagcgaata
     2881 cggcaaactg atttcctatc cgttcaaagg cactaccgcc agcgacctcc gcatcgtgct
     2941 gaacgatgac cgcgtcagta ttgccgaagt taaattttaa tgtgctaatg tgccaatatg
     3001 ctaatgtacc aatgaccatg cagcatatac agcgcagcca attagcacat tagcatattg
     3061 gcacattaac acattaaatt aatgaaaaca cttcttttct gtatgctcgg attaggtttg
     3121 acagcatgtg gctcttctcc aaagggcact aacggtgacc aggacgaact cgccatgcta
     3181 ataggtactt acacgaatgg ctcaagcaag ggtatctata ccttccgctt taatcaggag
     3241 acgggaacag ccgttccgct cagttcagcg gcattgccca atccctccta cctcgtcccc
     3301 tcggaagatg gcgaatttgt ctatgccgtc agtgaaatga acgacagcac agcagccctc
     3361 agctcccttg ccttagaccg ggaaacggga gaactgcgcc tgctgaacac cgttcccacc
     3421 ttcggcgccg acccctgcta cgtggccacc aatggccggg aagtgttgac tgccaactac
     3481 agcggtggaa ccatgtccgt ctttccttta cagaaagacg gtactttggc tcctgcagac
     3541 acgctctttc aaggctctgc caccggtccc gacgccatac ggcaagccac tccccacatc
     3601 cattgcacgg tcttttcacc ggacggaaag tatatcttcg ccaccgactt cagtgccgac
     3661 cgcatcctgc gctttgtgat gcaccccgac gaccctattc ctcatgcttc tctggaagcc
     3721 gttgacattg aagcggattc cggcccgcgc catctgacat tcagccctaa cgggaagttt
     3781 gcctatctca tcaccgaact gtccggtaag gtcattgcct tcagttacga cgacggctgc
     3841 ctggaacaga tacagactat cacagccgac accgtagccg cccgtggaag tgcagacatc
     3901 cacctcagtc cggatgggaa atacctctac gccagtaacc gtctgaaaga agacggcatc
     3961 gccatctttg ccgtgaatcc cgaaaatgga accttggcaa aggtaggtta tcagcccacc
     4021 ggcatccatc cccgcaactt caacatcacg cccaacggca aatacttgct tgccgcctgc
     4081 cgcgacagca atgtcattca ggtatacaaa cgaaacgaag ttaccggact cttggaagat
     4141 actcatcagg acattgtagt cgacatgccg gtttgcgtac agttcgtcag ctctgttaat
     4201 aatttataaa gcaatattta gcaaagataa cttcattaac tttgtccctt agctaaatca
     4261 gtctaaacga atgtacatta tgaagaagaa tatattgatg ctctcagctc tgttcttgtc
     4321 tatcactgcc atggcgcaaa cagacgtaac caccggtgtg atgcgtggca aagactacgg
     4381 agtgacttat atgttgccca aaacagaaat agaaatcgta ttgcaagcca ccaaacatac
     4441 ttacactccc ggagaatttt gcagatatgc cgaccgctat ctgcgtctca acaacgtgtc
     4501 tgccgaaccc gaggagttct ggacactgga taagatagaa acccgcatag ccggtgtacc
     4561 ggataaggac aacgtctatt tcgtgaagat gaaagacaag accgtagcac cccttatgga
     4621 gcttaccgaa gacggaattg tccgctccat caacattccg ttcagcggta agcctgctgc
     4681 caagacgccc gaagccaaag ccaccgaaag cagcattgac ccacgcagtt ttctgacgga
     4741 agaaatactg atgtccaact ccagtgccaa gatggccgag ctggtggcta aggaaatata
     4801 cagcatccgc gaaagcaaga atgccctcct gcgcggcgaa gcagacaata tgcccaagga
     4861 cggcgcccaa ctcaagctga tgcttgacaa tctgaaccag caggaaacgg ctatgacgga
     4921 aatgttctcg ggcaaaataa agaaagaacc caagacattc accatccggc tgacgcctaa
     4981 agagatgaaa gatgaagtgg ctttccgttt ttcccgaaag ctgggagtgg tggccaataa
     5041 tgaccttgcc ggtgaaccgt attatatcag cgtcaccgac ctcaaaagtc ccgatgtatc
     5101 tgccaccgag gaaggcaaaa agaaagtgga cggtgtagcc tataaccttc cgggcaaggc
     5161 acaagtgaca ttggtgtata acaataagaa attgtttgac gaccaacttc ccattaccca
     5221 attcggcacc gtagaatacc tcgcaccggt actgttcaac aagaattcta ccatcaaagt
     5281 gctgtttgat acggcaacgg gaggattgat aaaagtggat agggaataaa ggaattctaa
     5341 ttccggattg tcaactggat aaatccatcc ttacgcaact gcattacgta ggcggtgacc
     5401 cggggaatat aattctcttc ctccccaaag tgcctggcaa gtagagagat gatttcgcgc
     5461 acggtacgat gtccatctat cagattccag acagctgtac cgtgttcttc cagcctcaca
     5521 tggatgtcag gagacatccc cttcggcaat aaaaaacgac gcatccattc gtatttaaac
     5581 cgtgggtagg cgagtacggc gcactcacct tcccattcgg ttgttatatg tccacagcgg
     5641 accggaacag cgtccaacag acttactttt ccttcgggta tttccatcat acggtatccg
     5701 cttttcctat tatttctgaa tattaggctc ttccagctta taaccatact tcttgtctgc
     5761 cttcttcagc agtagagcca ctataaggga caagcaggca ataccggtaa aaatgcacat
     5821 aggcaccgta tagtcataca tattcgttcc atctggtttc ttgccggata tacaataggc
     5881 atcaagcacc caccctatca atgtaggaat accccaaaga ccgatattct ggataaagaa
     5941 aatcaatgcg tatgccgtac ccaactggct taccgggaat atcttggcca cagccggcca
     6001 catggcagaa ggtaccagcg agaaagcgat acccaaaatt atcatcagca caatagctac
     6061 cagccaatag tttatatcgg gaatagcata aatgaaatgc acacatatca gcatggccga
     6121 gcccagcagc atgatagatg cggacttgcc ccgcttgtca atgaaaccac caaagaccgg
     6181 agtcagaatc agcgctccca atgccggaag tccggcaaat gtaccggcta cattctcatt
     6241 gataccgtat ttgataatca tcaactcgga agcaaacttc tggaatggga atacacaaga
     6301 gtagaacaat acacacagca atgctatcag ccagaaaccg ggattgacca gaatattctt
     6361 cacatcctta aaagagaact tctcttcctc atcttccgta ccggcagcaa tggcagcagc
     6421 ttccatctgt ttgtccagct tcttgtccat cactgcaaag atgaagaaag caatcatacc
     6481 gcccaacaac agaaccaaac ccaacaacac cggtgtggaa ataccgaaag cgcgggccaa
     6541 aggaatggct acggcataac cggcttgcga accgatacgt gctaaagcga cttgtacccc
     6601 catagccgtg gcaagctctt tccccttaaa ccacttggct atgattttgg aaactgtaat
     6661 accggcgacc tccgctccta ctccaaaaat ggaataaccg gcaaaagcaa caaacacacc
     6721 cgttttatag ccaaatattt cattgattcc gaataaagtc gcgtcggcac cggcaagtcc
     6781 cgtcattgca tagtattcaa gtgctgtacc acctaccatc aggatagttg ccagctttcc
     6841 ggtgaaacgg ataccaaagc ggtcgaggat taatcctccc caaatcaaca tcaggaaaaa
     6901 aacattcaga aaactataac caccggtaaa gaatccgaaa tcggtactcg accaagccaa
     6961 gtccgtttcc aacattgtct tcaacggtgc taccacgtcg tttacataat aagctgccat
     7021 catcgtgaag gcaacaatca ccaatgcccc ccaacgggta gccttggaat cattcaattt
     7081 aagtttgagt tgttctgtca ttgtactatt tggatttcaa tttattaatc agattgcata
     7141 aattgctgac aaaggtaaat aaatacttca tcaaaacgaa aaaaggctga caccttttca
     7201 gtatcaacct ttctcttatt tttccaagcg ggagtcatcc gcaatatcct tatcttattc
     7261 tgctgcaggg gcttctgctg caggagcagg agcttcagcc ggagttgtag ctgcaggggc
     7321 ctccgattgc ggagcttctg tacctacggg catgttataa ggattagttt tttcttcttg
     7381 ttgcgcctgt tccagaatca catcaccgcc cttgcctgtg gaagaaggaa tagtgtaagc
     7441 agaaacaata ctgaagacta ccatgacagc tgccagagtc caggttgctt tttccaaaaa
     7501 gtccgtagtc ttgcgcacac ccataatttg gttggatgat gaaaagcctg atgccagacc
     7561 acctccttta gaattttgaa tcaatacaat gaagcacatc agcacagatg caatcagcat
     7621 taagataact aataataaat acattttgtt attttgattt agcgttaata atcaatttct
     7681 ccaaaaatct gatttggtct gcaaagtaag catttttttt tggataattc aaacttaatt
     7741 ttttaataat ttcaagcgcc ttgtcatatc ggtgctgttt tatatagatt ttggctaaag
     7801 tttccgtaaa acagctatcg tccaactctt ccgttaccgg cgatacggag ggttcttcct
     7861 cttcttcagt ctcttcctcc ttctctacaa gaaactccct tctcgtatcc gaggcatccg
     7921 aagactcact cttttggata aagtcatcta tcaattcatg cccgcgcagt ttaggcactt
     7981 ccgactcatc ttctgcatcc acaccgggtt cttcctgcat taaataggcc gtataatcca
     8041 ccgcataatc cagctccgta tgctgtgaat gctcttcggg aacagtagcc agaaatgcgt
     8101 caatcaagga aagggtacgg tccacactcg gctctttctc caaatcgccg gaaaacagcg
     8161 acgagacctt ccgggatttc aaagtatagc ggtcaccctc tataaagtaa aacagcacac
     8221 gacggtctgc cacatacaac acagccttgc gcaactccgc gccaaagttg atgtcgtgca
     8281 gcagatagag gtttttcaga tagagcaaac ggagcgactg gaaataagga tagcgtgcca
     8341 ccaatgtgcg aagctcgtac aaagtatccc tattcagcgt ctcgggatgc tgaatccatt
     8401 gttgcaaatg ggtaggcgtc atgagtttac cagttagcta cagttgcatt gaaaatctgt
     8461 tcggcaatgt ctttcaccat caaggttatc agctggtcct gcacttcggt cagcaatttt
     8521 gaggaatcat aggtctggaa agccgagaac tgctgttcaa agtcctcctc atggttcgtg
     8581 ttattggtgt aacgcacgtt gacagtcagc gtcaccttca ccttcgaaga gtagccgctg
     8641 gcatccaccg attcattata ttgattgtag ccggttattt ctccgtctat ttccaggtct
     8701 cctccggaat tcaccagttg caggcgagtc tgctgaatga acatatcctt cattttctgg
     8761 ttaaattctg ttgccagcgg tgcatataca tactctgccc ggttctggaa atcggcaatg
     8821 gaaatcgttt ttacctttgt atagtcgata gagcttatcg gagcaagtcc caacttcata
     8881 ctacatgaat tcaccagaaa taacaagctt accaacaagg aagcaaatgc cgctttttta
     8941 atccaatcca tattctttta tctttctgta taacgtacgc tcagagatat tcaaatcctg
     9001 agccgcactc ttacgcttgc cgtgatgttt ttcaagcgcc ttacgtatca tttctttctc
     9061 cacttcatcc agggagagtg actcctccac atattcttcc gtatcctgga aatcatcgtc
     9121 caccggagta accggctttg ccgaaggatg tataatggtg gggacactgg atgttaccgg
     9181 aggtaccacc gccggagtag ccggcgtata gtaggccgat gtggcaaccg ccggattggc
     9241 taccgttccc ctttcagcca taatctcatg caccaacttt ttcaagtccg ttacatcctg
     9301 gcgcatatca aacagaacct ggtagagaat ttcccgttca ctcccaaagc tcttgtcctc
     9361 cttcactcca aacaaggcag gcaggcgctg catattgttc tgctcaggca gatagccctt
     9421 cagtatggat gcattgattt cacgattggt ctcaatgatg gatatctgct cggtgatatt
     9481 cttcaactgg cgcacattac ccggccatga gtagcccagc aacacttgct tgccgtcttc
     9541 cgtcagctga atggcaggca tacggtactt ttctgcaaag tccgaagcaa actttcggaa
     9601 cagcagcacc acgtcttcac cgcgttcgcg caatggaggg acctgaatag gaactgtgtt
     9661 caaacggtaa tacaagtctt cacgaaaacg tccgtcagca atggcttgtg tcaagtttac
     9721 attggtagcg gcaacaatac gcacatcggt cttttccacc ttagaagaac ctactttgat
     9781 gaattcaccg ctctcgagca cacgcaacaa gcgtgcctgg gtaggcaaag gcaattcgcc
     9841 gacttcatca aggaagattg ttccgccgtt ggcctcaccg aaatacccct tccgttcgcc
     9901 gatagccccg gtaaatgcgc ccttctcatg accgaacagt tccgagtcaa tcgtcccttc
     9961 gggaatggct ccacagttca cggcaatgta ctgtccatgc ttgcgccggc tgtactggtg
    10021 tattatctgc ggaaagctct cctttcccac accactctct ccggtaatca gtacagacaa
    10081 gtcggtgggc gctacctgga tagcgatatc aatggcacgc atcagcgctt cattgttgcc
    10141 gataatgccg aaacgtaatt ttacttgttg tatttccgct tttgtcattc tacaaatctt
    10201 cttctacact atcgagtttc agtttgtcgc tatcgtcacg tttctcgtaa tattgcttgc
    10261 gcagcggatt tgcatgtgcc tctttctcac gctggcggtt acggaacaca tctattgcca
    10321 catagatagc ctgccggaat gaatcttcag aggcgattcc tttcccggca atatcgtagg
    10381 ccgtgccatg agcaggcgaa gtgcgtatca ccggcaagcc ggcagtatag ttcacgccct
    10441 cgtccatagc caatgccttg aacggtgcca gcccctggtc gtgatacatg gccaggatac
    10501 catcaaaatg ggtaaagtta tctgagccca taaacccgtc tgccggataa ggaccatagc
    10561 aaagcatacc cttagcagcc atttcgttga tggccggaat gataatctcc tgctcttcag
    10621 ttcccagcaa tccgccgtct cctgcatgcg gattcagcga aagcactgca atacgcggtg
    10681 cgctgatagc aaaatcctgc ttcaaggagc ggttgaatat cttcagtttt tcttgtatca
    10741 gttctttggt gatgcttccg gctatctctt taacgggaat atgtccggtc accaatgcta
    10801 cccggaagtc atctttcatc agaatcataa gggccttctc gccatctccc aatttttgct
    10861 ctatatactc cgtatgtccg gggaaggcaa actcctccga ctggatggta tgcttgttga
    10921 tgggagctgt gacaatcacg tctatcattc cctccttata ttcctcaatg gctttttcca
    10981 gtgcaccaag tgcagcttta ccagcttcaa cgtcaggttt agagaactca acctttactt
    11041 catcatccgt acagttcact acactcaagc gattgggaac cgcttcggag gcagagttga
    11101 cgatactgaa attggtagac aagtccaatg atttacgatg ataagctgcc actttaggcg
    11161 aaccgtagat aatcggcgta cacaattcca gcatcaccgg gtctgcaaac gtctttaaaa
    11221 tcacttcata ccctacacca ttaatgtcgc cttgtgtaat gccgactctt attttgttgt
    11281 cttccatttt tattacttat tattagtagt atcttttgcg gttacgccta ccggaatttc
    11341 cgcaccttcc agcttgctgc caggcagttt caaggtatag agcgaagcct ccatctgacg
    11401 taccagatta cgtttcattt tatcaggtga ataaataaat atttcagata cgataatacg
    11461 ctgattggct ttgtccaaac gtacatgcga tacgaacgga ccgcccatga agtcaccctt
    11521 tatgcgccac aagccgcggg cctccaatgc atagtctccc tgcacactga tagggcgtac
    11581 atcggtcatc agagaatccg tcgacatata catgccttca cgggcaccag ggatgttagc
    11641 cttcatcacg gaatcgcgtt tatgaacaaa atattcttta gtaaacgtat ccttatccgt
    11701 ataaggataa gagtagatta caaagttctg gtcgccggta gctgcattcg tacctgccca
    11761 gaagaagttc tccccctcct tggtagatgt cagttcgccc ggcacccata catcgcaatc
    11821 gaacaggctt ttcaccttcg ttgctatata gtcgctatgc ttgtccttca atactgaaat
    11881 ctgacgattc atttccgcat gagtaaagaa atcgatgatt acctgcctat tctcctccac
    11941 aaatttctcg aacgaagcct cgtccggcgc ctggatagtg agaatggact gaggagcagc
    12001 atatacattc cttgcatact tgaatttagg ctgggtatag aggtctttgt tcacatcgac
    12061 aataatgata ttgcgaatca gttttaaagt ggcatcataa ttggaagggg cagtatacat
    12121 gattcggaat gaacgttctg actggggaag ccccggaaca tcagaatcaa gcacatcgaa
    12181 aagcgcccta ccggcaggac gttcccacaa gccgggctcc accactacca gaacttcata
    12241 cgcacgacca ctggaggtcg gagtaaacac acccttttta ccaccaccgc aagcggaaaa
    12301 aagtgtcagt acgagaacca tacttaaata aaacaagtgc tttctcatat ctctatcatt
    12361 ttagtttttc acaaagctac gaagaatgcg taatatcctc cctacctaag ttaataattt
    12421 atattaattc ttctttattc tcctcctgct tggcagtgga caacatgcca caagcggcaa
    12481 atatatcctc tccacgcgat gaccgtatag tggtaaacag accgtgcgaa gtcagataat
    12541 cacggaacgc agtcatggtt tccatatcag ccccttcaag attcactcca ggtatggcat
    12601 gaaaacgaat caggttaatc cggcagtcca gcccgcgtag cagcttcaga agttcctttg
    12661 catacggtaa cgagtcattc actcctttga aaacaatata ttcaaaagat agtctgcgct
    12721 gtttgctaaa atcatagttt cttaacaatt ccacaatctc cgtgatggag aacgccttct
    12781 ctgccggcat cagttcgcgg cgttgcaaag gtatcggcga atgaaggctg atagccagat
    12841 ggcagtccga ttcctcaata aaacgctgca atcccttctt caatcccaca gaagaaagtg
    12901 taacacgctt gggactccac gcatacccat aagaggcggt cattatttcc agcgctttca
    12961 atacctcgtc cagattatca agtggttcac ccatgcccat cattaccaca ttggtaagct
    13021 tgtccctttc gggcaacgaa ttaatttgat taataatctg gttggatgtc agattggcag
    13081 taaaaccttg tttgccggtc atacagaact tgcaattcat cttacagccc acctgagagg
    13141 agacacaaag cgtagcccgg tcttcgtcgg gtatatagac agcttccacg aaatgcccct
    13201 cgcctgcccg gtacaagtat ttcaccgtac cgtctacaga gcgcatggca tctaccggcg
    13261 cttcggcacc tacctcatag atttctttca gcaattcccg atgcttcaac gaaagattgc
    13321 tcatttcgtc tatagaagtc accttcttgt catacagcca ggaagctatc tgcttggcag
    13381 agaaaccggg cattcccaga ttcttcacca cattctgcaa ttcagagagc gtcaagccca
    13441 atagaggtcg tttctgcata tcgtttttca ttaaaacaaa actctttcaa gaatgcaaag
    13501 gtaggaataa agttgcacaa agacaacgga gagtgtagaa aatgaaatgt acagacaatg
    13561 aaaaagccgc ccggaagtac cggacggctt ttcaatatgg gttttctatt cttagaagaa
    13621 taaataacgt tggtctttta cgttggcttt cagatacaag tcactgatga actggcttgc
    13681 catacgtgca tgcatgttag ccaagttagc ctcttcagtt tccttgttga atgtttcgtt
    13741 cagcttctct tttgcataag gttgcagaac gaatacacca ccgttaccct tgataggagc
    13801 actcagcttg ttcacttcgg caatagaagc gtatgcgcct accaaaggtt cgctgctacg
    13861 caatgccggg atataggcag gagcagagaa agtaacgtgc tttacagaat cactgacagc
    13921 atttgccata ttcttgtact gctcgaacga agttgcattg gcagccttca tatcagccat
    13981 aatcttctct gctttcttgt cacggagaat ttcagctttc aactggtcct ttaccaaagc
    14041 cagtgggcga taaccttcag gaacaatact tgcaacacct actaccagca tacggtcgct
    14101 ctcgccacat tcgtacaaac cggaaacttc accggctttt gcctcaaacg cccatttcaa
    14161 agcatctttg gttcctctga taccaccgat accatgttca gagctgtaca agtcggctct
    14221 atccagcaac ttgtaaccgg catcttccgc attggcaatc attttctcta aagtattgtt
    14281 tgcagcgatg aactggctaa actcattgta tgccttgctg taagtttcct tgctgaattc
    14341 taccggacgc ttgataacgg ctaccttata tttatccttg acagccttct tgttggttac
    14401 ttgcaaaatg acatttgctt gtcccaacgc cagattggtc agttcgttct gtcccaaagt
    14461 tgtgacagcg gtaatgtatt tcaagttgtc accgtcaatc tgtgcgcctt cgtagttagc
    14521 agaagaaatc caggtaggct caccggtctg accgtacttc ttcgcaactt cagcaaagct
    14581 ggcaccaccc ttaatagcat tgtagatgct gtcggccaaa atcttcgtct tttcagcatc
    14641 ttcggcaact acctgaatct gacggaactc gatagagtcc ggcatggcag cagtagccaa
    14701 tttcttgaaa gagttgaggg tattgtcaga tacgttataa taaggcccga acacaccacc
    14761 caccgcaaca gagtccaaac gggctgtcac atcagcaggc agagacttag tagtgtagaa
    14821 caagtctgta taaggagctt cggaaccggt agaacggata aaggtagtat agtcagaagg
    14881 attggcagta agttgttcgg tgtattcttc catttccttc tggagagcag ctctgtcttc
    14941 tgcacttgca gtaacttgca catcaatgaa cttgatattg cgagtttcca catattgctt
    15001 gaactgttct ttcttcttgt cgtatgcagc cttcaaatca gaatccttga taacgatggt
    15061 agagtcaacg atagaagaat agggaactgc agcaagcagc aggtctgact gctctactct
    15121 tgcatcaaaa gcgtcctgag cttctaccgg gttggagaaa agggattttg taatcaaagc
    15181 ttgatacttc tcctgaagac gtgcctggat aagggacttt tcgaggaaag accagaactt
    15241 gtacatggat tcatagtatt ctgcatattg tgaaggcatc tgtgccttat tcatttttga
    15301 atagtccacc aagaacttct tcaacatatc cttatcaaac gcaccggtct gaggattacg
    15361 gaacggagtc tgttgcagca tcggatgcac accggcatta atgatagcct gaatctcagc
    15421 cttcgataca accagaccga gtttctttgc ttccttttca atcagcttat tattgacgta
    15481 tgttctccat acttcatctt tgatttggtt tgtctgctca tcgctcaatg cactgttgcc
    15541 actggagaac ttgatgactt ctgtatattc ttctaccaat gcttgaaaat cctgagcgga
    15601 aattgattcc ccgttcactt cacctacgtc ttgtgactgg tgtggctgaa gcactttcca
    15661 cgcgtcacct gcgatgaaag caaacagcgc
//
