LOCUS       c00078_gnlPro..        14713 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CGLMDDOO_78.
ACCESSION   c00078_gnlPro..
VERSION     c00078_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 06:55:31
            Original ID  :: gnl|Prokka|CGLMDDOO_78
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14713
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14713
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[100:4713]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      101..4713
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14713
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14713
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(101..1261)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_1"
                     /sec_met_domain="OAD_beta (E-value: 3.3e-152, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(1263..1697)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.7e-21, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             complement(1721..2704)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_3"
                     /sec_met_domain="OAD_gamma (E-value: 7.9e-17, bitscore:
                     54.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVIFPCNQAFHTKTRTIMNKTKIGIFLSLMLVLGFCSSCKEQKSN
                     NKLLLNEVLVNNESNYQDDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIP
                     KGDVLTLIKPRQHALFWADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAG
                     TLKANQSYARVSDAADQWEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAI
                     SAMSVVFCGLILLYISFKIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAA
                     ISMAMHEFQSDVHDVEDTILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(2685..4238)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_4"
                     /sec_met_domain="CT_Btheta (E-value: 8.8e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(4297..4713)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.4e-25, bitscore:
                     82.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGDVKIELLEPTSPESTIAKFIEKNNGNGGMHHLAFAVEDGVAGALAEVEEKGIRL
                     IDKAPRKGAEGLNIAFLHPKSTLGVLTELCEKPE"
     CDS             4728..4826
                     /locus_tag="ctg78_6"
                     /transl_table=11
                     /translation="MLVLYPFNKGIKQHKEREFFLNKEIFHQLIHG"
     CDS             5002..6489
                     /locus_tag="ctg78_7"
                     /transl_table=11
                     /translation="MKKNILLAVCFLMPLATMAQNDTLGHERNITLSEAIVLARTQSVD
                     AAVALNELKTAYWEYRTFRADLLPEVNFTGTLPNYNKSYSTYQNSDGSYSFVRNNTLGL
                     SGQLSVDQNIWFTGGKLSLTSSLDYLKQLGSGGAKQFMSVPVSLELTQPVFGVNTLKWN
                     RRIEPVRYAEAKAEFISATEEVTMKTITYFFELLLAKESLATAMQNKTNADRLYEVAIA
                     KRKMGQISENDLLQLKLNSLQGKADVTEAESNLNAKMFQLRSFLGVSEQESLNPVLPAT
                     VPDIKMEYDRVLNKALERNSFAQNIRRRQLEADYEVATARGNLRSIDLFASVGYTGQNH
                     EFSSAYRDLLDNQIVQVGVKIPILDWGKRRGKVRVAKSNREVVLSRIRQEQMDFNQDIF
                     LLVANFNNQAQQLDIAEEADVIAEKRYKTSVETFMIGKISTLDLNDAQNSKDEARQKHI
                     SELYYYWYYFYQLRSLTLWDFERDTELEADFEEVVRG"
     CDS             6632..7993
                     /locus_tag="ctg78_8"
                     /transl_table=11
                     /translation="MILIIDDDSAVRSSLSFMLKRAGYEVKTAPSPREAMDIVRAEAPA
                     LILMDMNFTLSTTGEEGLTLLKQVKVFRPDVPVILMTAWGSIQLAVQGMQAGAFDFITK
                     PWNNAALLQRIETALELTAAPKEVPEEQTTALNRSHIIGKSKGLMEVLNTVARIARTNA
                     SVLITGESGTGKELIAEAIHINSQRVKQPFVKVNLGGISQSLFESEMFGHKKGAFTDAS
                     ADRIGRFEMANKGTIFLDEIGDLDPSCQVKLLRVLQDQTFEVLGDSRPRKVDVRVVSAT
                     NADLRKMVSERTFREDLFYRINLITVKLPSLRERREDIPLLARHFADRQAEVNGLPRTD
                     FSADALNFLSRLPYPGNIRELKNLVERTILVSGKPVLDAADFDAQYLRHDEPAKAAEGS
                     SFAGMTLDEIERQTILQALEQHKGNLSQVAVSLGISRAALYRRLEKYNIQVPCA"
     CDS             7984..9297
                     /locus_tag="ctg78_9"
                     /transl_table=11
                     /translation="VRIKFFFFILVLFLLGLGGMLVYLLSGKPLLYLYVLEGIIGFILI
                     YLIVFYNKIVKPMNTIGSGMELLREQDFSSRLSRVGQYEADRIVNIFNRMMEQLKNERL
                     RMREQNHFLDLLIQASPMGVVILTMDDEVSQLNPMAVKMLGVRMEEAMAKRLDQMDSPL
                     AAELSSIPKDETAVVRLNDANIYKCTHSSFIDRGFKHPFFLIERMTEEVMRAEKRAYEK
                     VIRMIAHEVNNTTAGITSTLDTVEQALSTEDDMEDICDVMRVCTERCFSMSRFITRFAD
                     VVKIPEPTLVPVQLNELVSMCKRFMEGMCNDRNIELRLECDPEVGMVRMDASLFEQVLV
                     NIIKNAAESIEGDAGENGQQGEIIVRTTAPASVEVVDNGPGISKETEAKLFSPFFSTKP
                     NGQGIGLVFIREVLSRHGCTFSLRTYNDGLTRFRILFN"
     CDS             complement(9331..10965)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GlcNAc_2-epim"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_10"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7.8e-22, bitscore:
                     70.3, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="GlcNAc_2-epim (E-value: 0.00089, bitscore:
                     11.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTKLLEKKMESISPFELKNRLIDMADESLKKTARTMLNAGRGNP
                     NWIATAPREAFFLLGSFGLEECRRIMDLPEGIAGIPEKKGIASRFEAFLKKNNNVPGVK
                     LLEQTYNYLLMQHAADPDSLVHEWAESIVGDQYPVPDRILHFTEILVQDYLSQEMCDNR
                     PPRGAYDLFATEGGTAAMCYIFDSLQENFLLDKGDGIVLMVPAFTPYIEIPQLSRYQFR
                     VTKIHANRMNNEGMHLWQYSDEDIDRLKSPKIKALFVTNPSNPPSYTLSPDTMARIVSI
                     VRNDNPNLMIITDDVYGTFSPHFRSFMAEIPYNTLCVYSFSKYFGATGWRNAVITLHEF
                     NLFDKLIAKLPKEKREILHHRYSTLTLEPEKLKFIDRMVADSRQVALNHTAGLSLPQQM
                     QMGLFAAFALLDKENKYKQKMQEIIHRRLHALWENTGFTLTEDPLRVGYYTEIDMLVWA
                     KKFYGDDFVEYLKRTYSPLNVVFRLAKETSLVLLNGGGFDGPEWSVRASLANLDEKDYA
                     TIGRGIKKILEEYAKEFFKNGKAKGKN"
     CDS             complement(11242..12936)
                     /locus_tag="ctg78_11"
                     /transl_table=11
                     /translation="MEWIFNQLRERPELAIFLTIFLGFWLGKLRIGKFTLGTVTSVLLV
                     GVLVGQLNIAVPGPIKSVFFLLFLFAVGYKVGPQFFRGLKKDGLPQVGFAVLMCVSVLL
                     VTWLLALMMGYNAGEAAGLLAGSQTISAVIGVAEDTMANMGLDEAQRQSYVNIIPVSYA
                     VTYIFGTAGSAWVLSSIGPKMLGGLEKVKAACKELEAKMGSSLADEPGFMPAARPVTFR
                     AYRVENEWFKNGKRVIDLEVYFRQHDKRLFVERLRKSGVVVEVSMNIQIEPGDEVVLSG
                     RREYIIGEESWIGPEVQDAQLLDFPAEKLPVTITRKTVAGKTVAVIRREKFMHGVSIRS
                     IKRAGISIPVLAQTVVDAGDVIEVVGTRQEVEAAAKRLGYIDRPTNQTDMIFVGLGILV
                     GGLFGALSVHIGGIPISLSTSGGALIAGLFFGWLRSKHPTFGRIPEPSQWVLNNVGLNM
                     FIAVVGISAGPSFVQGFHDVGISLFLVGAAATALPLIIGLLLARYVFKFHPALALGVCA
                     GARTTTAALGAVQDAVESETPALGYTVTYAVGNTLLIIWGVVIVLLI"
ORIGIN
        1 gtctgggctt tgcgcataaa aaaaggctgt gtcagcattt tgacacaacc tctctaaaat
       61 agttcagaat tcaagccgga taacggaatg aataaatgta ttacattaag aatcccagca
      121 ggatacctgc tgctacagcg gaaccgatta caccggcaac gttcgggccc atggcatgca
      181 tcagcagata gttggtagga tcgtattcca gacctactac ttgggagata cgtgcagagt
      241 cgggtacggc agatacaccg gcattaccga tcaacggatt aatcttgttg cctttcttca
      301 ggaagaggtt gaaaatcttc acgaagatga caccggatgc tgtggcaatg acaaatgata
      361 aggcgcccag accgaatatc ttgattgaat caagggttaa gaactcggat gcttgcgtag
      421 aagcacctac tgtcaaacca agcagaatag taatggtatc aatcagcgga ccactggctg
      481 tgtttgccag acgacgtgta actccacttt ctttcagtaa attaccgaag aacagcatac
      541 ccagcaaagg cagaccggat ggtacaagga atgtggttag taacaaaccg ataatcggga
      601 acattacttt ttccgtatgt gaaaccacac ggggaggttt catacggata agacgttcat
      661 ttttactggt cagccaacgc ataataggcg gctgtatcac cggtactaat gccatatatg
      721 aataggctga taccgcaatg gcacccatta agttaggagc cagtttggaa gagaggaaga
      781 tggcagtcgg accatcggca ccaccaatga taccgattgc accagcctgc attgggtcaa
      841 atcctatggc aagggcaatc atataagcac cgaatatacc gaattgggct gctgcaccaa
      901 ccaacattaa tttggggttc gatatcaaag cagagaaatc cgtcatggca ccgataccca
      961 ggaatatgag tggcgggtac caaccggagg ttactccctg gtacagaata ttaagtacgg
     1021 aaccttcttc atagataccg actttcaatc cggcttccat attgaaaggt atattaccaa
     1081 tcagcatacc gaaaccgata ggaattaata gcatcggctc aaattccttg gctacagcca
     1141 agtatatgaa aaacaaacct accagaagca ttaccacatg tcctaccgtt gcattggcaa
     1201 aacctgtata agtccagaag tcggcaaggt tgtttcctaa aaatgtgata aattctccca
     1261 tattattcaa taattacgag gtcagtacct tcgagaacag agtccccttt gtttacattg
     1321 atggctgtaa tcttaccgtc tttatcagca ttgatattgt tttccatctt catggcttcc
     1381 agaatgatga taacttgtcc cttctttact gtatcgccga catttacttt gatatcgagg
     1441 attacaccgg gaagcggaga ttttacacct gacttgccgg tagaagcagc ggccggtttt
     1501 actaccggag tagcaggagc agcaggagcg gatgtggctg ccggacgtgc taccggttta
     1561 acgactacct tcggtgcttt ttccatttca actttgtagg gagtaccgtt cacttctacg
     1621 tgagcgatgt tgtcttcaat atctccaatg gcaactttat atacgttacc gttaatttta
     1681 tatttatatt ctttcatcgt tttattttat tatgggtgac ttactttttg tgaggagtct
     1741 cacgcaacgt ataaatcttt gaactccacg gtgagtaact gcgttttaca cgggtaatgg
     1801 taagtatcgt gtcttccaca tcgtgtacat cgctttggaa ttcgtgcatg gccattgaaa
     1861 tggcagcaaa aacttctccc ggagcctgcc ccagttgttt ctcttttgct tcttgtttat
     1921 cagtaatacc tttagctttc atggcattgc gtttgctgag gttaactgat attttaccta
     1981 taatcttgaa ggagatgtag agtaatatca gcccgcagaa tacaacgctc atggcagaaa
     2041 tagccatacc gatacctacg ctgtcatgct cttcgaattt ttccattttg gcattgctgt
     2101 cgatagtctt gttgttggta ctcggagtga catatttatc ttcgcttcca ccctttactt
     2161 cccattggtc ggctgcatca ctgacacggg cataggattg gttggctttt aaagtaccgg
     2221 caggcactat gacttgatca agcaatttct tgccagaatc atacaaccca atccagttgg
     2281 catttgtggc atccagtttg aagttcgtat gaaaagtacc gcgtcttggc tctccatcag
     2341 cccagaaaag tgcatgctga cgtggtttta tgagtgtcag aacgtcacct ttgggaatga
     2401 aataactggc agtatcaccc ggctggctgc tgaatttcag atagcaacct gcaaggtcgg
     2461 cgctgccgta tgatctgttg aatatttcaa tccatgcgct gtgcacaccg tagtcatcct
     2521 gatagttgct ctcgttgttg accagcactt cattcagtaa cagtttgttg ttcgatttct
     2581 gttctttgca agaagagcaa aagcccaaca ccagcatcaa tgaaaggaat attccgattt
     2641 ttgttttatt cataatcgtt cttgttttag tgtgaaaagc ttgattacaa gggaatatta
     2701 ccatgcttct tagccgggtt agtcaatttc ttggtttgca actgttgcag ggcacggatg
     2761 atgcggaaac gtgtgttacg cggttcgata acatcatcga tgtaaccata tttagctgca
     2821 ttataaggat tggcaaacaa cttggtgtat tcagcctctt tttcagccag gaattgagcc
     2881 ggattttcct gctctttggc ttcgcgagca tataatactt ctacagcacc tgcaccaccc
     2941 attacagcga tttcagcagt aggccaagca taattcatgt cgccacgcag ctgcttacag
     3001 ctcatcacga tgtgcgaacc accgtaggat ttacgcagtg taatggtaac cttgggtaca
     3061 gtagcttcac cgtatgcata cagcagtttg gcaccgtgca ggatgacgcc gttgtactcc
     3121 tggccggttc ccggaaggaa tcccggtacg tctaccaatg atacgatagg aatattgaag
     3181 gcgtcgcaga aacggacgaa gcgtgcgccc ttgcgggatg cgttgctgtc gagcacacct
     3241 gccagatact tcggctggtt ggcaacgata cctacggact gtccgttgaa acgtgcgaaa
     3301 ccgataatga tattctttga ataatctttt tggatttcga ggaactcacc attatctatg
     3361 atagcgccaa ttacctcgta catatcgtac ggtttgttcg ggttatcagg aatgatgtcg
     3421 ttcagggaat cttccagacg gtcgataggg tctgtgcagt ctacataagg agcttcttcc
     3481 agattgttct gtggaatgta gctcaacagt ttgcggataa gagccaagcc ttcttcttca
     3541 gtctgtgcag tgaaatgagt aacacctgat ttggtggagt gaacgctcgc gccacccagg
     3601 ttttcctggc ttacgtcttc tccggttaca gtctttacta ccttcggacc ggtaaggaac
     3661 atgtaggatg taccttccat catcagcgta aagtcagtca atgcaggaga gtaaacggca
     3721 ccaccggcac aaggaccgaa aataccggaa atctgcggaa tgacacccga agcaaggatg
     3781 ttacgttgga agatttcagc gtagccagcc aaggcattga taccttcctg aatacgtgca
     3841 ccgcccgagt cgttgatacc gatacacgga gcacccattt tcatggcttg gtccataatc
     3901 ttacagattt tcagagacat ggtttcggac agtgaaccgg cggaaacagt gaagtcttgt
     3961 gcaaagatat aaaccagacg gccctcgatt gtaccgcaac cggttaccac accgtcaccg
     4021 gggtagtgtt tcttttccat gccgaagttc gtacatctat gttctacgaa catgtccatt
     4081 tcttcgaaac tgccttcgtc aagaagcatg gctatacgct cacgagctgt atatttaccc
     4141 ttctcgtgtt gctttgcaat cgctttttca ccaccaccga gacgtgctgc agcgcggcgg
     4201 tctataagct ctttaatctt ttcaagttga ttactcatga atttatattc tttaagtgtt
     4261 tatacaattt atgatttgat gattttacag tcttgcttat tccggtttct cgcaaagctc
     4321 ggtcaggaca ccgagagttg acttcggatg caggaatgca atgttcagac cttctgcacc
     4381 tttgcgggga gctttgtcta taaggcggat acctttttct tcgacttctg caagcgcacc
     4441 ggccactccg tcttcaacgg caaatgccag atgatgcatg ccgccgttgc cgttgttctt
     4501 ctcaatgaat ttggcaattg tgctttcggg agaagtaggt tccaacaatt cgatctttac
     4561 atcgcccact ttcaggaaag cggttctaac tttctgatct tccacggttt cgatgttgta
     4621 gcatttcaaa cctaaaacgt tttcgtagta cggaagggct tcttcaatgc tcttaacggc
     4681 aatgcccaga tgctcaatgt gtgaaatctt cataactata taaattaatg ttagtattgt
     4741 atccttttaa taaaggtata aagcagcaca aagaaagaga attcttcctt aataaagaaa
     4801 tttttcatca attaattcat ggataattga actttagaag gattttttca gactttagat
     4861 agagaccggt tgttttcctg atatcgtccg ctaacggaca tccccactgt ccgaaaatga
     4921 acacttaccc ctctatgaaa cctttccggc cacttggcac actctttgct tttctgtttg
     4981 cgacaatttt aaagattgaa catgaaaaag aatattttac ttgcagtttg ttttttgatg
     5041 ccgttggcaa ccatggcgca gaatgatact ttgggacatg aacgcaatat tacgctgtcg
     5101 gaggccattg tactggcccg tacgcagtct gtggatgctg ctgtggcatt gaatgaattg
     5161 aaaaccgcgt attgggaata ccgtacattc cgtgcggact tgttgccgga agtgaatttt
     5221 accggtacac tgcccaacta taacaagtcc tacagtacct accagaattc cgacggctcc
     5281 tatagctttg tccgcaacaa tacactgggg ctgtccggcc agctttcggt agaccagaac
     5341 atttggttta cggggggtaa gctgtcactg acttcttcgc tggattatct caaacaactg
     5401 ggttccggag gagcgaagca gttcatgtca gtccccgtga gtttggagtt gacgcaaccg
     5461 gtcttcggag tgaatacctt gaagtggaac cgccgtatag agcccgtacg ctatgccgag
     5521 gcaaaggccg agttcatttc agctacggaa gaggtgacga tgaaaaccat cacttatttc
     5581 tttgagttgc tgctggccaa agaatcgctc gctaccgcca tgcagaacaa gacgaatgcc
     5641 gaccgccttt atgaagtggc catagccaaa cgtaagatgg gacagatatc cgagaatgat
     5701 ttgctgcagc ttaaactgaa ttcattgcag ggtaaggcgg acgtgactga ggcagagagc
     5761 aacctgaatg caaaaatgtt ccagctccgt tctttcctcg gggtgtccga gcaggaaagc
     5821 ttgaacccgg tgttgcccgc cactgttccc gatataaaga tggagtatga ccgtgtgctg
     5881 aacaaggcac tggaacgcaa ctcctttgca cagaacatcc gccgccgcca gctcgaagct
     5941 gattatgaag tggcaacggc acgcggaaac ctgcgcagca tcgacctctt tgccagtgtg
     6001 ggctatacgg ggcagaacca tgaattctct tcagcctacc gggatttgct tgacaatcag
     6061 attgtgcagg tgggcgtcaa gattcctatc cttgactggg gcaagcgccg tggtaaggta
     6121 agggtggcaa agagcaaccg tgaagtggtc ttgtccagaa tccgtcagga acagatggac
     6181 tttaaccagg acatcttttt gctggtggct aacttcaaca accaggcgca acagctggac
     6241 atagccgaag aggcggatgt cattgctgag aagcgttaca agaccagtgt agagaccttt
     6301 atgataggta aaatcagcac actggacctg aatgatgcac agaactctaa agacgaagcc
     6361 cgtcaaaagc atatttcaga gctgtattac tattggtatt acttctatca gcttcgcagc
     6421 ttgacccttt gggattttga acgcgatacg gaattggaag ctgattttga agaggtggta
     6481 agaggataag ccgacgggtt gcaagtgata agttatgagt tattcgccgg taaaagtgcc
     6541 gtatatgcga tattattggt aaataactta taacttatca ttcataactc tgctttttta
     6601 cttatttttg tggaaaataa actgcaattt tatgatactg ataatagatg acgatagtgc
     6661 tgtgcgctct tccctcagct ttatgctgaa gcgtgccgga tatgaggtga aaacggctcc
     6721 aagtcctcgc gaagctatgg acatagtgag ggccgaagct cccgctttga ttttgatgga
     6781 tatgaacttc actctttcca ctaccggaga agagggactc accttattga agcaggtaaa
     6841 ggtgttccgt cccgatgtgc ccgttatttt gatgacggca tggggaagta tccagcttgc
     6901 cgtgcagggg atgcaggccg gcgcattcga tttcataacc aagccttgga acaatgctgc
     6961 tcttttgcag cgcatcgaga cggcccttga gcttacggcc gccccgaaag aggtgccgga
     7021 agaacagact accgcattga atcgcagcca tattataggt aagtccaaag ggctgatgga
     7081 agtgttgaac acagtggccc gcatagcccg taccaatgct tcggtgctga ttacgggcga
     7141 aagcggaacg ggcaaggagc tgattgccga agccatccat atcaacagcc aacgtgtgaa
     7201 gcagcctttt gtcaaggtga atctcggcgg catctcgcag agcttgttcg agagtgagat
     7261 gttcggccat aagaaagggg cgtttaccga tgccagcgct gaccgtatag ggcgtttcga
     7321 aatggcaaac aagggaacca tcttcctcga cgagattggt gacctcgacc cttcctgcca
     7381 ggtgaaactg ctgcgtgtgc ttcaggacca gacattcgaa gtgctgggcg atagccgtcc
     7441 ccgcaaagtc gatgtacgcg tcgtgtccgc tactaatgca gacctccgta agatggtgtc
     7501 cgaacgtact ttccgcgaag atctttttta ccgtatcaac ctgattaccg taaaactgcc
     7561 ttctttgcgg gagcgccgtg aagatattcc tttgctggca cgtcactttg ccgaccgtca
     7621 ggcagaggtg aacggcttgc cgcgtacgga tttctcggcc gacgctctga atttcctttc
     7681 ccgcctgcct tatccgggca acattcgtga gttgaagaat ctggtggagc gtaccattct
     7741 ggtcagcggc aagccggtgc tggatgctgc ggatttcgat gcccaatatc tgcgtcacga
     7801 cgaaccggcc aaagctgccg aaggtagttc ttttgcaggt atgaccttgg atgaaataga
     7861 gcggcagact atcttgcagg cgttggaaca gcataaaggg aatctcagtc aagtggcagt
     7921 gtcattaggc atcagccgcg ctgcgcttta cagacgttta gaaaaatata atattcaagt
     7981 cccgtgcgca taaaattctt tttcttcata cttgtccttt ttctgctcgg tctgggtgga
     8041 atgctggtat atttgctgag tgggaagccg cttttgtatc tgtacgtatt ggaggggatc
     8101 atcgggttta tccttatcta tctgatagta ttctataata agatagtgaa gccgatgaac
     8161 accataggca gcggtatgga gttgctgcgc gagcaggatt tcagtagtcg tctcagccgg
     8221 gtagggcagt acgaagcaga ccgcattgtg aatatcttta accgaatgat ggagcagctc
     8281 aagaatgaac ggttgcgcat gcgcgagcag aatcacttct tggatttgtt gattcaggca
     8341 tctccaatgg gggttgttat cctgacaatg gacgatgaag tgtcgcaact gaatccgatg
     8401 gcggtaaaga tgctcggtgt ccgtatggag gaggcgatgg caaagcggct ggaccagatg
     8461 gactccccgt tggctgccga actttcgtcc attcccaaag acgagacggc agtggtccgt
     8521 ctcaatgacg cgaatattta taaatgcacc cattcttctt ttattgacag agggttcaaa
     8581 catccttttt tcttgataga gcgtatgacg gaagaagtga tgcgtgccga gaagcgtgcc
     8641 tatgaaaagg taatccgcat gatagctcat gaagtgaaca ataccactgc gggcatcact
     8701 tccacactcg atacagtgga gcaggcactt tctacagaag atgatatgga ggacatctgc
     8761 gacgtgatgc gcgtctgtac ggagcgttgt ttctcgatga gccgtttcat tacccgtttt
     8821 gcagatgtgg taaagatacc tgaacctacc ctggtgcccg tccaactgaa tgagttggtg
     8881 tccatgtgca agcgttttat ggaaggaatg tgcaatgacc gcaatataga gctacgtctg
     8941 gaatgcgacc cggaggtggg aatggtgcgt atggatgctt ctctttttga gcaggtgctt
     9001 gtgaatatca tcaagaatgc cgccgaaagt atagaggggg acgccggaga aaacggacag
     9061 caaggtgaga taatagtaag gaccactgcc cccgcttctg tcgaagtcgt tgacaatggt
     9121 ccggggataa gtaaagagac cgaagctaaa ctcttcagtc ccttcttttc caccaagccg
     9181 aacgggcagg gaattggcct ggtgtttatc cgggaagttt tgagccgtca tggttgcacg
     9241 ttctccctac gtacctacaa cgatggattg acccgcttcc gtatactatt taattgaaat
     9301 ttgaaagttt tacctttcac ctttcaattt tcaattttta cctttcgcct ttccattttt
     9361 aaagaattct tttgcatact cctccagtat ctttttaatg cctcggccga tggtcgcata
     9421 gtctttctcg tccagattgg cgagtgaggc gcgcacgctc cattcggggc cgtcaaaacc
     9481 accgccgttc agcagcacca gagaggtttc tttggcaagg cggaagacta cgttcagcgg
     9541 gctgtaggtg cgtttcagat attctacaaa gtcgtcccca tagaacttct ttgcccaaac
     9601 cagcatgtcg atttctgtat aataacctac gcgcaacggg tcttccgtca gcgtgaaacc
     9661 ggtattctcc caaagggcat gcaatcggcg gtggataatc tcctgcatct tttgcttgta
     9721 tttgttttcc ttgtccagca gggcaaaggc ggcgaaaagg cccatctgca tctgttgtgg
     9781 caatgacagt ccggcggtat ggttcagtgc cacctgacgg ctgtcggcaa ccatacggtc
     9841 gataaacttc agtttttcag gttccagagt gagggtggag tagcggtggt gcagaatctc
     9901 ccgtttctct ttcggcagtt tggctatcag cttgtcgaac aggttgaatt cgtgcagggt
     9961 aatgaccgca ttgcgccatc cggtggcacc gaagtatttg gagaatgaat agacgcaaag
    10021 cgtattgtag ggaatttctg ccatgaacga acggaaatgt ggactgaatg taccgtatac
    10081 gtcgtctgta ataatcatca gattagggtt gtcattcctg acgatgctca cgatgcgcgc
    10141 cattgtatcc ggactgagtg tgtagctggg cggattactg ggattggtga caaagagggc
    10201 cttgatttta gggcttttca agcggtctat gtcttcgtcg ctgtactgcc agaggtgcat
    10261 cccttcgtta ttcatgcggt tggcatgtat tttggtcact cgaaactggt agcggctgag
    10321 ttgtgggatt tcaatatagg gggtaaaggc aggaaccatg aggacgatgc cgtccccttt
    10381 gtccagcagg aagttttcct gcagggagtc gaagatgtag cacatggcgg ctgttccacc
    10441 ttcggtggca aacaggtcat aggcaccccg gggaggacgg ttgtcgcaca tctcttgcga
    10501 aaggtaatct tgcacaagga tttccgtaaa atgaaggatg cggtcgggca cgggatactg
    10561 gtcgcctaca atgctttcgg cccattcgtg tacaaggctg tcggggtcgg cggcatgctg
    10621 catcagcagg tagttgtagg tttgttccag caatttgacg cccggtacgt tattgttctt
    10681 tttcaggaag gcttcgaagc gagaggcaat gccttttttt tcggggatgc ctgcaattcc
    10741 ctcgggcaaa tccatgatgc ggcggcactc ttccaggccg aagcttccca ataggaagaa
    10801 ggcttcgcgt ggagcggttg caatccagtt ggggttgccg cgccctgcgt tcagcatggt
    10861 acgggcggtt ttcttcagac tctcgtctgc catgtctatt aggcggttct tcagttcgaa
    10921 aggactgata gattccattt tcttttctaa aagttttgta tccataagct caagtttagg
    10981 ttcgttattt attgttttca gtcattcggt gaataatctc tgttcatgcg gtatactatt
    11041 tctttccttg cttgaaatta atcgtccgat atatgtttcc ttttcgtccg acagttgttg
    11101 aatcatcgtc cgacagctgt tgaattatcg tccgacagct gtcggacgaa tagctattag
    11161 tgaatgggta tatagtcgct tgcatttccg gcaataattc tttgaatgat ttggattagt
    11221 aagtattggc acagaatcgt cttatattag caaaacgatg actacacccc atattattaa
    11281 taaggtattg cccacggcat aggtcacggt gtatcccaga gcaggtgtct cactctcaac
    11341 ggcatcctgc accgcgccta aagcggccgt agtggtacgt gcccctgcgc agacgcccaa
    11401 agccagtgcc ggatggaact tgaaaacata ccttgccagc agcaagccga taatcagcgg
    11461 cagggcggtg gcggctgctc ccaccagaaa cagactgata cctacgtcgt ggaagccctg
    11521 cacgaaactg ggacctgccg aaatgcccac taccgcaatg aacatgttca gaccgacatt
    11581 gttcaacacc cattgcgaag gttcgggaat gcgcccgaag gtggggtgct tactgcggag
    11641 ccagccgaag aacaagcccg caatcaatgc gccgccgctt gtgctcaagc tgatggggat
    11701 gccgccgata tggacggaaa gtgctccgaa caaacctccg acaaggatac ccaggcctac
    11761 gaatatcata tccgtctggt tggtaggacg gtctatatac cccagacgtt tggctgctgc
    11821 ttccacttcc tgcctggtac ctaccacttc gatgacgtcg ccggcatcta ctaccgtttg
    11881 tgccagtaca ggaatggata ttccggcgcg cttgatgctc cggatactga caccgtgcat
    11941 gaacttttcc cttcggataa ctgcaaccgt cttgccggca accgtcttgc gtgtgattgt
    12001 aaccggtaac ttttcggcag gaaaatccag gagctgggca tcttgtactt ccggccctat
    12061 ccagctttct tcgcctatga tgtattcgcg gcgtccgctt agcactactt cgtctcccgg
    12121 ctctatctgt atgttcatgc tgacttccac cacaactccg gatttgcgga ggcgttccac
    12181 aaatagacgt ttgtcgtgct gccggaagta gacttccagg tcaatcaccc gctttccatt
    12241 cttgaaccat tcgttttcga cccggtaggc acggaaagtg acggggcgtg ccgccggcat
    12301 gaatcccggt tcgtcagcca gagagctgcc catcttcgcc tccagttcct tgcaggcggc
    12361 tttcaccttt tccagcccgc ccagcatctt gggaccgatg gatgatagga cccatgccga
    12421 gcctgccgta ccgaaaatgt aggtgacggc gtaggatacg ggaatgatgt tgacgtaact
    12481 ttgtcgttgg gcctcgtcca gtcccatatt ggccatggtg tcttctgcca ctccgatgac
    12541 ggcagagatg gtttgcgaac cggccagcag tccggcagct tcaccggcat tgtagcccat
    12601 catcagggcc agcagccagg tcactaacag tacggataca cacatcagta cggcaaagcc
    12661 cacttggggc aatccgtcct ttttcagtcc gcggaagaac tggggaccca ctttatagcc
    12721 cacggcaaaa aggaaaagca gaaaaaatac cgactttatc ggacccggta cggctatgtt
    12781 cagttgccct accagtacgc ctacaagcag tacactggtc actgtgccca gcgtaaactt
    12841 accgatacgc agtttcccca gccagaatcc caggaatata gtgaggaaaa tggcaagttc
    12901 ggggcgttcc ctgagctggt tgaaaatcca ttccataatc aagttgttta ggttatatat
    12961 tggttgttcc gatgctttct ggagcgtcgt ttcgctatac aacggctttt aacgggaagt
    13021 gttttataca aaaggagttt tttagaacat ttattccgta aaaccgaact ttaagaaaaa
    13081 gttttcttcc gtacctttgc catccaaatt aggtaaaaca aggtatgaag ttgtttttta
    13141 gggtatttct gcttatccag ctggttactc ttccattgag agcacaatat atggtgcaag
    13201 gcgttgtcac cgattcgttg acgaaggagc cattgcctta tacgtcagtt tatctgaaag
    13261 gaactacgga gggagggatg acggacaata acggccgttt ttccttcaag acctatcgcc
    13321 cggaggccac gctggtcatt tcggccgtgg gatataatga atatgtccgg ttgattcatc
    13381 cagcaaagtc ttctaagttc aatattgccc tttcgccagc cacttatgca ctggatgagg
    13441 tggtggtgaa gccgaaacgt gaacggtata agaaaaagga taatcccgca gtggagtttg
    13501 tacgcaagat gatagagcat cgggatgact actcgcccga cgaacgcgac ttctggaaac
    13561 gtgaccgcta tgaaaagatg acttttgcca tcaataactt cgacagcctg aagcaacaga
    13621 agtggcttta ccgtaagttc aagtttctga cggattatgt cgatacctct gccgttaccg
    13681 gcaggccggt attggccatc tccaaccgtg agttgcttgc cacagactat taccgcaagt
    13741 ctccgcatag ccggaaacag tgggtcaccg cccgcaggca ggcaggagtg gacgaaatgc
    13801 tttcccagca gggtatggag caggctatca gtgtcaccat gaccgatgtg gacctttatg
    13861 agaacaacat caccttgttc accaataagt ttgtcagtcc gctttcctcc cttgggccgt
    13921 ctttctacaa atattatctg atggatacgc ttaccgttgc cggaaagcct tgtgttgact
    13981 tgacatttgt ccctttcaac tccgagtcgt tcggttttac gggacattta tacgtcatgc
    14041 tggacagtac ctattttgta aagcgtgccg tcatgaactt tcctcagaaa ataaatctga
    14101 actttgtgga ctacatgaag attgaacaga attttgaccg cgcggaggac ggtacgaggc
    14161 agttgctcaa tgagagtatc actacggagt tcaagttggt ggacaatagt gacggtattt
    14221 atgccaagcg ggatgtgtat tacagaaatt atcagtatga accggatgac aaggctctgc
    14281 aggctttccg aaaagcggaa aaggtgattg aagagacatc ggcttccggc tattcggaag
    14341 catattggga tgccaaccgc caggtggagg tcagcaagaa agagacttcg gtggacaaga
    14401 tgatggccca gttgcgcagc tatcccgttt atttctggac ggagaaagtg ttgaaggtgc
    14461 tgttcacggg gtatattccc gctccgaagg aaaaagaacc tttgttctat atcggtatga
    14521 tgaataccac tatcagcgga aatacactgg aaggggtgcg cttgcgtgcc ggcggtatga
    14581 cgacggcatg gctcaatccg catttgttcg gcaggggcta tatggcatac ggttttcgcg
    14641 accatcgtgt aaagggactc gccgaactgg aatattcttt tcataggaag aaggaatatg
    14701 ccaatgaatt tcc
//
