LOCUS       c00310_gnlPro..        12931 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MPPCIFMB_310.
ACCESSION   c00310_gnlPro..
VERSION     c00310_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 04:34:14
            Original ID  :: gnl|Prokka|MPPCIFMB_310
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12931
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..96)
                     /locus_tag="ctg310_1"
                     /transl_table=11
                     /translation="MNDTAAAILKATAALRDGTEKLRFEYPGHVTY"
     protocluster    1..12931
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4323:11459]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4324..11459
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..12931
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12931
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             225..1169
                     /locus_tag="ctg310_2"
                     /transl_table=11
                     /translation="MTSGGDAAGMNPAIKAAVDHARQLGMNPYVVYDGLEGLIDGKIKE
                     ATRELTNDMIYRGGTLLRSSRSKRFFDYEFRKQAYEHLKKRNIDKLIIMGGDGSFRALN
                     DFFNDFEVPFAGIPATIDNDFAGTDYCRVVDTAQNVILDCIDSVRDTARSHHRAFVIET
                     MGRDCGYLAMTTALCSAADICIVPEIPYDLESIYKRLQPVINEEGSCIIAVVAEGTRVA
                     QYLTRWLTERAGMDTRLTVLGHVQRGGSPTARDRLMGTRFATRAVEALNNGDINQIMVY
                     HDGQYGYASLDSVAGQQYSVNQDIINLCRELSC"
     CDS             1301..2353
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg310_3"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 4.8e-98, bitscore:
                     318.3, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVIVTGGAGFIGSNLVRLLLERGHEVLNIDALTYAGNIHSLDGS
                     ADSPAYLFLHADVRDASLMRRTLREYAPDWVMHLAAESHVDRSIDDPGNFMTTNVMGTF
                     SMLQSALEYYRSLEGEKKERFRFHHISTDEVYGSLGKEGLFTESTPYRPHSPYSASKAS
                     SDHLVRAWHDTYGLPVLITNCSNNYGPYQFPEKLIPVVILKALGGEPIPVYGKGENVRD
                     WLYVGDHCEALLTVVSCGKPGETYNIGGNNEKTNLELVELLCSHLDELRPRPDGRSYRE
                     QISFVQDRPGHDLRYAIDASKIRRELGWTPRQDHSSGFRKTIQWYLDHEEWWRGILSGE
                     YRLERLGTNG"
     CDS             2363..3226
                     /locus_tag="ctg310_4"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAG
                     IREILVISTPRDLPLYRDLLGDGSRFGVSFEYREQPRPEGLAQAFIIGEEFIGKDSVAL
                     VLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEKPLR
                     PKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWL
                     DTGTHDTLLEASMFVRTLEHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRY
                     LDELVK"
     CDS             complement(3504..4205)
                     /locus_tag="ctg310_5"
                     /transl_table=11
                     /translation="MNWMIYPAARAFIKVCAVLFGAGATAAALIHLFMPFFLRSPRTAA
                     PFLLLGTGAELLSILSLSFLMFWGARVLLASRGSKITRNLSMLAFLPALYALLIPFAGM
                     PASSQYTEMDRVWEAFLLLASVISFFSFPYTAGYGAAGRRLFLAWGISAAGCGLQSALF
                     FLAVLLRQFLTTAVPSLAAPVAWLAVLLSCGLEIMLAALSVILARRLFKEVMSIASMPE
                     SIDPSMPGNLP"
     CDS             complement(4324..5820)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hydro"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hyd_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg310_6"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 7.3e-47,
                     bitscore: 148.9, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 5.2e-44,
                     bitscore: 140.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQEVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNAAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVGVVETNWPDEARSFA
                     AADPLTDKIGQNVADFLAADMKRGIIPSTFLPLQSGVGNIANAVLGALGRDKTIPAFEM
                     YTEVIQNSVIGLIREGRVKFGSACSLTVTNDCLEGIYRDMDFFRDKLVLRPSEISNSPE
                     VIRRLGVISINTAIEADIYGNVNSTHIGGTKMMNGIGGSGDFTRNAYISIFTCPSVAKD
                     GKISAIVPMVSHHDHTEHDVNIIITEQGVADLRGKSPKERAQTIIENCVHPDYKNILWD
                     YLKLSDGKAQTPQSIRAALGMHAELARSGDMKNVDWAQYK"
     CDS             complement(5882..6661)
                     /locus_tag="ctg310_7"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARSLPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPADTAAGVHWGHLPLVAGLALFNMLRG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVASIAGEIKDPPAR
                     LADLVRDCPSLHAVMASLGSHLNQVLSVFSHGGVSALQEGLSWAWAGERPVSILTDDET
                     VRGIFTGIDDQGNPVLSLPAGAVRTIPAHLINRLLEE"
     CDS             complement(6699..8324)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg310_8"
                     /sec_met_domain="OAD_beta (E-value: 8.6e-160, bitscore:
                     521.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVFSLSWQMVGMWGIAILLLYLGVAKQYEPLLMVPIAFGALIAN
                     IPDNGMLITQLNQQVISSNEQGEVTSTSLNNVGYLRVHVAPLQQTPAKVPANLTTPEAR
                     AQYLETMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAARLGDDSLTVDPNLKDFQNVT
                     EDNGNEPVFLLTNGEGTTVVRQQGVNYFDTSGNRVPVDLKTQKLEPLVVSAAGKYVAVG
                     QHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLLAAPRTLLLGAAAQ
                     VGVAATFFMALFMGFNPNEAASIGIIGGADGPTSIFLTMKLAPHLLGAVAVAAYTYMSL
                     VPLIQPPIMALLTTKKERLIRMKSLRTVSKSEKLFFAVLVTIVTILLIPDASPLIGMLM
                     LGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQAETLLIILLGIVAF
                     GVATAGGVIAAKLMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVGQKYDPSNYLLMHA
                     MGPNVAGVIGTAVIAGYYIATLAK"
     CDS             complement(8442..8849)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 57.2; E-value:
                     3.9e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg310_9"
                     /sec_met_domain="Biotin_lipoyl (E-value: 8.2e-19, bitscore:
                     57.2, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRITVDGKVFDVSVELLDQVSSTTAAPAPAPVAAPAPAASAP
                     VATPAPAPAPAPAPAPAAAGAGDAPSPLAGKVVSLDVAAGAPVKAGDQILTLEAMKMNT
                     IIYAPASGTLTAFCVNPGDTVQEGQALAKIG"
     CDS             complement(8924..9370)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg310_10"
                     /sec_met_domain="OAD_gamma (E-value: 2.8e-11, bitscore:
                     33.8, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLTTLAFAQGIANVMNNLNYQIVGIMVVMMCLGGLAVILTISGS
                     IAAAIQNRAKAKTAAPVAAPAAAPAAAGKPGMTPEMLAILSAAVDSAMTELTPEMVAVI
                     SAAVDAGLDGMSHRIVEIKQSPGSGYAAAGRAEIFASHRIRPSR"
     CDS             complement(9392..10957)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg310_11"
                     /sec_met_domain="CT_Vparvula (E-value: 1.2e-216, bitscore:
                     709.8, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYL
                     FEEGTFSEIGMHVRHNCHNFGMGKKEIPGDGVVSGFGLVDGRPVACAASDFLAQGGSLG
                     YMHAMKIADAQKYALKAGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVVPQI
                     SMILGPCAGGAAYSPALTDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHA
                     TVSGNVHFVADSDAHAMDILKRLLSFLPSNNTEEPPHKLDTPLDLSADEGMSDLIPGDN
                     RTPLDVQPIISRLVDNGDFLEVHKDFAKNVVVGFGRICGVVVGIIANQPNVKAGCLDID
                     SSDKAARFIRFCNAFNIPLVNLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVT
                     LIMRKAYGGAYIAMCCKDLGADAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKA
                     KRQGELLEEYREAFYNPYVAAGMGQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHG
                     NIPL"
     CDS             complement(10989..11459)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg310_12"
                     /sec_met_domain="Glyoxalase_4 (E-value: 9.4e-26, bitscore:
                     80.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYCRPPPCIPYNHHTHMIQQIDHIGIAVKSLDATVPYYRDALGLG
                     EPHIEEVPTQKVRVAMFDVAGVHIELLEPTSPESAIAKAIEKKGEGIHHIAFKTNDIAG
                     NISQAKEAGLTVLNDPPVPGAHNTQVTFLHPKCTFGVLTEFCQHPGGCECGK"
     CDS             11577..12929
                     /locus_tag="ctg310_13"
                     /transl_table=11
                     /translation="MFKSGLAVLFLLASWFSASCAYELLPAHVAVVYNGKSELSRRMAR
                     EYARVRGVPEGNLVSLDCPTTSEISRKEYEDTIRVPLLEAARKQRWWVPSGIASSPLMN
                     RKIFVLVLMADLPMKIRHETPAPLPGKGVNQMQTDRAAVDSELALLAVGGYERKSWQVN
                     PYFNKREDFVGSGLPSFLVCRLDGLTPDTCRRLVAEPANVEKKGLWGWAVVDRGGPYAQ
                     GDRWLDDVFERVREAGIPAYLDDWPQTLPEKFPLSRDTALYCGWYAGNANGPFSDPSFR
                     FRPGAIAMHLHSFSAADFKVPGRGWSSALLEKGAAVTVGNVYEPFLGACHRFDIFVDRL
                     LDGYTVAEASWMSMPVLSWQGLVFGDPLYRPYARMKDMDVEPTEEDRYFQGWWASSVQF
                     GDRWKDRSARLMESARKAPFSCLYEALALECLYRKEPARAGELLSSALAGAA"
ORIGIN
        1 gtaggtaaca tggcccgggt attcgaaccg gagcttctcc gtgccgtccc ggagggcggc
       61 cgtggctttc agaatggctg ctgcagtgtc gttcatgcct ccgcatcatg aagtgttgcc
      121 gtttattgcg ccagtaaaaa ctccgcgctt gcattatttg ttccgcccgg taacatttcc
      181 ccccggacaa gttaacctta ttacttatga gtggaatagc cattatgaca tctggcggtg
      241 atgccgccgg aatgaacccg gcgatcaagg cggcagtgga tcatgcccgc cagcttggga
      301 tgaacccgta cgttgtttat gacggcttgg aagggctgat cgatggaaaa atcaaggaag
      361 ccacccggga actgaccaac gatatgatct acaggggcgg aactctcctc cgttcctcac
      421 gatccaagcg ctttttcgac tacgaattcc gcaagcaggc ctacgaacat ctgaagaaac
      481 gcaacatcga caagctcatc atcatgggcg gggacggttc cttccgcgcc ctgaacgact
      541 ttttcaatga ttttgaagtg ccttttgccg gtattccggc cacgattgac aacgactttg
      601 ccggcacgga ctactgccgg gtcgtggata cggcccagaa cgtgattctg gattgcattg
      661 attccgttcg tgatacggcc cgttcccatc accgcgcttt cgtgattgaa acgatgggcc
      721 gggactgcgg ctatctggcg atgaccaccg ctctttgcag cgcggcggat atctgcattg
      781 tccctgaaat tccgtatgac ctggaatcca tttacaagcg cctccagcct gtcatcaatg
      841 aggaaggaag ctgcatcatt gccgtggtgg cggaaggcac ccgcgtggcg cagtacctga
      901 cccgctggct gacggaacgc gccggcatgg atacccgcct gaccgtgctg ggccatgtgc
      961 agcgcggcgg ttcccccacc gcccgtgacc gcctgatggg cacccgtttt gccacccgcg
     1021 ccgtggaagc tctgaacaac ggggacatca accagatcat ggtgtatcat gacggccagt
     1081 acggctatgc ctccctggat tccgtagccg ggcagcagta ctccgtgaac caggatatca
     1141 tcaacctttg tcgggagctg agctgctagc cgtctcagcg gttacggaac ccgctttttc
     1201 ccgcccatgc cgccacgttc ccgcggcatg ggcggatttg ttttgaaaaa aaacgccgct
     1261 gctgtatgat ggcgccgcat ctttccctga aaacagtgct atgaaagtta tcgttacggg
     1321 cggcgccgga ttcatcggct ccaatctggt caggctgctg ctggagcgcg gccatgaagt
     1381 cctgaatatt gacgccctga cctatgccgg caacatccat tcactggacg gctcggcgga
     1441 ttctccggca tacctctttc tgcacgccga cgtccgggac gcttccctga tgcggcgcac
     1501 tttgcgggag tacgctccgg actgggtgat gcacctggcg gcggaatccc atgtggaccg
     1561 ttccattgac gatccgggaa attttatgac caccaacgtc atgggcactt tttccatgct
     1621 tcagtccgcc ctggaatatt accgttccct ggagggagag aaaaaggagc gtttccgctt
     1681 ccaccacatt tccacggatg aagtgtacgg ctccctggga aaggaaggcc tgttcacgga
     1741 gtccacgccg tatcgccccc attccccgta ttccgccagc aaggcctcca gcgaccacct
     1801 ggtgcgcgcc tggcacgata cgtacggact gcccgtgctg atcaccaact gttccaacaa
     1861 ttacggccct taccagttcc cggaaaagct gatacccgtc gttatcctga aagcgctggg
     1921 cggggaaccc attcctgtat acggcaaagg ggaaaacgtg cgggactggc tgtatgtggg
     1981 ggatcactgc gaggctctgt tgacggtcgt ttcctgcgga aaaccggggg aaacgtacaa
     2041 catcggcggc aataacgaga aaaccaatct ggagctggtg gagctgctgt gttcccatct
     2101 ggatgaactg cggccccggc cggacggccg gagctaccgg gagcaaatct cctttgtgca
     2161 ggacaggccg ggtcatgacc tgcgctatgc gattgacgct tccaaaatac ggagggaatt
     2221 ggggtggact ccgcgccagg accattcttc cggattcaga aagaccattc agtggtatct
     2281 ggaccatgag gaatggtggc ggggcatcct gtccggggaa taccgcctgg aacgtcttgg
     2341 aaccaatggc taggaatttg atatgaaggg tattgttctg gccgggggaa gcggcacgcg
     2401 tctgcatccc gttacgcttt ccgtcagcaa gcaattgctg cccgtttatg ataagccgat
     2461 ggtttattat cccatctctg tgctgatgct ggccggaata cgggaaatcc ttgttatttc
     2521 cacgccccgg gatctgcccc tgtaccggga tttgctgggg gacggcagca ggttcggcgt
     2581 ttcctttgaa tacagggaac aacccaggcc ggaggggctg gctcaggcct ttattattgg
     2641 agaggagttc ataggaaagg attccgttgc cctggtgctg ggggacaata ttttttacgg
     2701 gcgcggcctg acggagaagc tgaggcgggc cgccgaactg acgagcggag cgaccatttt
     2761 cggttaccag gtgcatgacc cgcagcgttt cggggtagtg gaattcaatg aggaggggaa
     2821 ggcggtttcc attgaggaaa aaccgctcag gcccaaatcg gatattgcgg tgacgggcct
     2881 ctatttttac gacaaccggg tggtggagat agccaaacgg attcccaagt cttcccgcgg
     2941 cgagttggaa atcacctctg tgaatcagga atacctgaag cagggcctgt tgcgcgtgga
     3001 aaaactggcg cgcggttata cgtggctgga tacgggcacg cacgataccc ttctggaggc
     3061 ttccatgttc gttcgtactc tggagcacca ccaggggttc aaggtagcct gcctggagga
     3121 gatagccttt aataacggct ggatttccca ggaaacgctg cgctcccagg ccggagccat
     3181 gaataataac ggttatggcc gttatctgga tgaattggtg aaatagggct gtctgccgcc
     3241 ggcgtggaaa cgggaggggt gttcctgcga acccgcggct ttccggggtg gggcgggttg
     3301 ctttccggca atgctttcca tacggattcc gttccaccgg cggaaatttc cggacggctt
     3361 tttgcgcaaa gccgtaaaag cctttcatgc cgggatgcgg cagccgggtt ggaagaaggc
     3421 tgccgtgagc ggttcgcgta ttcatgccgc ggactggggg taaccccttc caactggctg
     3481 caaacatgaa ggcagggggg aagtcaggga aggttgcccg gcatggaggg atcaatcgat
     3541 tccggcatgg acgctatgga catgacctct ttaaacaggc gccgcgccag aatgacggaa
     3601 agggccgcca gcatgatttc caggccgcag gacaaaagaa cggccagcca tgcaactggc
     3661 gctgccaggg agggaactgc tgtggtcagg aattgacgca acaggacggc aagaaaaaac
     3721 agggcgctct gcaaaccgca tcctgccgcc gagatgcccc aggccaggaa taatctcctg
     3781 cctgcggcgc cgtatcccgc cgtataaggg aaggaaaaga aagaaatgac ggacgccaga
     3841 aggaggaagg cctcccaaac cctgtccatt tccgtatatt gcgatgaggc gggcatgccc
     3901 gcaaacggaa tgaggagggc gtacagggcg ggcaggaagg ccagcatgct cagatttctt
     3961 gttatcttgc ttccccggga ggccagcaga actctggcgc cccagaacat gaggaaggac
     4021 agggaaagga tggagagcaa ttccgcccct gttcccaaaa gcaggaaggg cgcggctgtc
     4081 cggggagagc ggaggaaaaa aggcatgaac agatggatga gggctgctgc tgttgcgccc
     4141 gcgccgaaaa gaacggcgca gactttgatg aaagccctgg ctgccgggta aatcatccag
     4201 ttcatggtga agaaaaggag tagaggggat agaaaaaagg aaaaggaccg ctccctttgc
     4261 ggaagcggtc ctgaggggtt aacgtgaatt catggatgcc aatgcgagtg acggcatgcg
     4321 gaattactta tactgggccc agtcgacatt cttcatgtct ccgcttctgg ccagttcggc
     4381 gtgcatgccc aaagcggccc tgatggattg cggcgtctgg gctttgccgt cggacagctt
     4441 caggtaatcc cagaggatgt ttttgtaatc cgggtggacg cagttttcaa taatggtctg
     4501 ggcccgttct ttcgggctct tgccgcgcag gtccgcgacc ccctgctcgg taataatgat
     4561 attgacgtca tgttccgtat ggtcatggtg ggaaaccatg gggacgatgg cgctgatctt
     4621 gccgtccttg gcaacggacg ggcaggtgaa aatggagatg taggcgttgc gcgtgaagtc
     4681 gccggacccg ccgatgccgt tcatcatctt cgtgccgcca atgtgcgtgg agttgacgtt
     4741 cccgtaaatg tcggcttcaa tggcggtgtt gatggagatg acgccgagac ggcggataac
     4801 ttccgggctg ttggatattt ccgagggacg gagcaccagt ttgtcgcgga aaaagtccat
     4861 atccctgtaa atgccttcca ggcagtcgtt cgtcacggtc agggagcagg cgctgccgaa
     4921 tttcacgcgg ccttcccgaa tcaggccgat gacggagttc tggatgactt ccgtgtacat
     4981 ctcgaacgcg ggaatcgtct tgtcgcggcc cagggcgccc agcaccgcgt ttgcgatgtt
     5041 gcctacgccg gactggagag gcaggaatgt ggagggaatg atgccccgtt tcatgtcggc
     5101 agccaggaaa tcggccacgt tctgcccgat tttatcagtc aggggatccg ctgcggcgaa
     5161 ggaacgggct tcatccggcc agttggtttc cacaacgccc acaatctttt tcgggtcaac
     5221 ctggatgtac ggcttgccga tgcggtcgct gggtttgaag atggagattt cgcggcggta
     5281 gggaggatcc aggggttcgt aaacgtcgtg caggcccatg gcgctcttgc tgtgggcggc
     5341 gtttaattcc acgataattt tgtctgccag gcggcagatg gtgggagcga tcccgcccgc
     5401 ggccgtcagg taaattttgc cgtcagccgt gacttcacag gcttcaataa tggcgatgtc
     5461 cacgttgccc atgaacccgt agcgcacttc ctgggccatc tgggacaaat ggatgtcatt
     5521 ataggcgatt tccccgttgt tcaccgcctt gcggaaatca acgttggtgg tgtagggagc
     5581 gcggtagcgg attgccttgg cccgggaaag gatcccgtcg caggaatcgc cggtggaagc
     5641 accggtgaag acgctcacct ggaaagggtt ccccttctca tgttccgctt ctgcgatttt
     5701 tgccagcgcg gccgtaacgg ccttggccgt tccggcgggc gtgaatccgc tcagcccaat
     5761 atggtggcca tgcttgatca ggcttgctgc ttcttctggt gtcagtacct tgtaactcat
     5821 gtcagtgatt tttgttggat gaaaaaagaa agaaaccccg tgtaaaaacg gagcggcagg
     5881 ctcattcttc gaggagcctg ttaatcaggt gcgccggaat ggtgcggacg gcgccggccg
     5941 gaagggatag cacaggattg ccctgatcgt caatccctgt aaaaataccc cggacggttt
     6001 cgtcatccgt aagaatggaa accggccttt ctccggccca tgcccaggac agaccctcct
     6061 gaagggcaga gacgccgccg tgggaaaaga cggaaagaac ctggttcaaa tgactgccca
     6121 gggaagccat gacggcgtgc agggaagggc agtcccgaac aagatccgcc agccttgccg
     6181 gagggtcctt gatttccccg gcgatggagg ctacatcatt gaaaacattg atgccgatgc
     6241 cgatgacggc catgttttcc gccgggcgtt ccaccagtat tcccgccagt ttggatttgc
     6301 ccgccagcag gtcgttcggc cagcgcaggc gcacggaatc cagccccatg ccgcggagca
     6361 tgttgaacag ggccagcccc gcaaccaggg gcaaatggcc ccagtgcacg ccggccgctg
     6421 tatccgcagg agcggacagg ggaacggtga aggatgccca caggccgcct tcctccccta
     6481 tccatttgcg gttgaacctg ccgcggcctc ctgtctgaac gcggcagacg gcaatatgcc
     6541 ccgggggcag ggagcgggcc aggtcattgg tggaaaaagc ctcggcccat tcatgataag
     6601 tccagtcgcc gcatggtcct tcctcctccg gaggggtgga aaatgaggct gcggaattca
     6661 tgggacgggc cgaggccggg agtaattttc aattctggtt atttcgccag agtggcgatg
     6721 tagtagcccg cgatgactgc ggtgccgatc acgcctgcaa cgttcgggcc catggcgtgc
     6781 atgagcagat agttggaggg gtcgtacttc tggcccacat tgtgggagac gcgggccgcc
     6841 atcgggacgg cggagacgcc tgcggacccg atgagggggt tgaccggatt cttgcgccag
     6901 atgaggttca tgagcttggc ggcgatgacg ccgcccgcag tggctacgcc gaaggcgaca
     6961 atgcccagca gaatgattag cagcgtttcc gcctgcagga agcggtctcc ctgcatcgtg
     7021 agacccacgg aggttcccag gaagatggtg acgatgttga tgatttcatt ctgggaggcc
     7081 tgaaccaggc gttccgtcac cttgcattcg cgcaggaagt tgccgagcat cagcatgccg
     7141 atgagcgggg atgcgtccgg aatcagcaga atggtgacaa tggttaccag cacggcgaag
     7201 aacagttttt cgctcttgct gaccgtccgc agggatttca tgcggatgag gcgctccttc
     7261 ttggtcgtca gcaacgccat gatgggcggc tgtatcagcg gaaccaggga catgtacgtg
     7321 tatgcggcca cggccacggc gcccagcagg tgcggagcca gcttcatcgt caggaagatg
     7381 gaagtggggc cgtcagctcc gccgatgatg ccgatggagg cggcttcatt cgggttgaag
     7441 cccatgaaca gggccatgaa gaacgtggcg gctacgccca cctgggccgc cgcgcccaga
     7501 agcagggtgc gcggtgcggc gagcagcggg ccgaagtccg tcagggctcc tacgcccagg
     7561 aagatgatgg gcgggaaaat ttcagccttg atgcccagcc cgatccagtc atacaggccc
     7621 ccgtggatgg aggtgaccag cagttcctgg gtatgttggc ctacggccac gtatttgcct
     7681 gcggcggaaa ccaccagggg ttccagcttc tgcgttttca ggtccacggg aacacggttg
     7741 ccgctggtgt caaagtaatt gacgccctgc tggcggacga cggtggttcc ttctccgttc
     7801 gtgagtagga agaccggctc attgccgttg tcctccgtca cgttctggaa gtccttcagg
     7861 ttgggatcca ccgtcagact gtcgtctccc aggcgggcgg cgtcagcttt ggctttttcc
     7921 tgggattccc gcacggactt gattttggaa acggtcagct ggctgccggg ataaacctgc
     7981 atgggctgct gcatggtttc cagatactgg gcgcgggctt ccggcgtggt cagattggcc
     8041 ggcaccttgg cgggcgtctg ctgcagagga gccacatgaa cgcgcaggta gcccacgttg
     8101 ttcagggacg tggaggttac ttccccctgt tcattggagg agatgacctg ctggttcagc
     8161 tgggtgatga gcattccgtt gtccggaatg ttggcgatga gggcgccgaa agcaatggga
     8221 accatcagga gcggttcgta ttgcttggct acacccagat acaggaggag aatggcaatg
     8281 ccccacatcc ctaccatctg ccatgatagg gagaagacgc ccatcccctg taaaaaggtg
     8341 attaatgaat caaaaagact catacggaat gttattgtag cggtttatta tttgagccgg
     8401 agcccgggac tgttggcgtt tccgggctgc cgccgccggg attaaccaat tttggccagt
     8461 gcctgtcctt cctgaaccgt gtcgcccggg ttcacgcaga aagcggtgag cgtgccggag
     8521 gcgggagcgt agatgatggt gttcatcttc atggcttcca gcgtcagaat ctggtcaccg
     8581 gccttcacgg gtgcgcctgc tgccacgtcc agggagacga ccttcccggc aagcgggctg
     8641 ggagcgtctc ctgcgccggc ggcggccgga gcgggcgcag gtgcgggagc cggagccgga
     8701 gccggggtgg ccacgggtgc ggatgcggca ggagcgggag cggccacagg tgcgggggcc
     8761 ggggctgcgg tagtggagga tacctggtcc aggagttcta cggatacgtc aaataccttg
     8821 ccgtctacgg tgatgcgaag tttcttcatg ataatgtatg gtatggagta ttaagttaaa
     8881 tggttcccgc cggggcgggg gtaagggtga ataatgctgt agttcaacgg gaaggccgaa
     8941 tgcggtggga ggcgaagatt tccgccctgc ctgcggccgc atagccggag cccggggatt
     9001 gcttgatttc cacaatgcgg tggctcatgc cgtccaggcc cgcgtccacg gcggcggaga
     9061 tgacggccac catttccggc gtgagctccg tcatggcgga gtccaccgct gcggagagga
     9121 tggcgagcat ttccggagtc atgcccggtt tgcccgccgc agcgggggcg gcggcaggcg
     9181 cggccacggg agcggcggtt ttggctttgg ccctgttctg aatggcggcg gcgatggagc
     9241 cgctgatggt cagaatgacg gccaggccac ccaggcacat catgaccacc ataatgccga
     9301 caatctgata gttcagattg ttcatgacgt tggcgatgcc ctgtgcaaag gcgagtgttg
     9361 tgagtaacat atgaatccgt tgagatggat gttagagcgg aatgttgccg tgtttcttgg
     9421 ccgggcgcac ttccttcttg ttcagcaggg tgcgcagggc gaaggcgatt ttggcgcggg
     9481 tttcttccgg attgatgact tccgtgatct gtcccatgcc ggccgccaca tacgggttgt
     9541 agaaggcttc ccggtattct tcaaggagtt ctccctgtcg cttggctttt tccgccgggt
     9601 cttccacagc cttcaattca cggccgtaga gcaccggaac ggcgccttcc gcgcccatga
     9661 cggcgatttc cgcgccgggc caggcgaaga cggcgtcagc gcccaggtcc ttgcagcaca
     9721 tggcgatgta ggcgccgccg taggctttcc gcatgatcag ggtgactttg ggcaccgtgg
     9781 cctgggaata ggcgaagatg agtttggcgc cgtggcggat aatgccgccc cgttcctggt
     9841 tcttgccggg taggaagccg ggcacgtcca ccaggttcac caacggaata ttgaacgcgt
     9901 tgcagaagcg gatgaagcgc gcggccttgt cggaggagtc gatatccagg cagccggctt
     9961 tcacgttggg ctggttggcg atgatgccga ctactacgcc gcagatgcgg ccgaagccga
    10021 cgacgacgtt tttggcgaag tccttatgca cttccaggaa gtccccgttg tccaccaggc
    10081 ggctgatgat gggctggacg tccagcggcg tgcggttgtc gccgggaatc aggtcgctca
    10141 taccttcgtc tgcgctcagg tcaagcgggg tgtccagttt gtgaggcggt tcttccgtgt
    10201 tgttggaagg aaggaaggaa agcagcctct tcaggatgtc catggcgtgc gcgtcgctgt
    10261 ccgctacgaa atggacgttg ccggatacgg tggcgtgaat ggcggcggag ccgatgtcat
    10321 ccatcgtgca tttttcatac gtgacctgtt caatcacctt ggggccggtg atgtacatgc
    10381 cggcgttgcc ggaattgcgc atgatgatga agtccgtcag ggcgggggag taggccgcgc
    10441 cgcccgcgca gggacccaga atcatggaga tttgcggaac cacgccggag gcaagcacat
    10501 tgttgtagaa cacctgggca tagccggaaa gggccgccac gccttcctgg aggcgcgcgc
    10561 cgccggagtc gttcacggtc accatcggga tgccggcttt cagggcgtac ttctgggcat
    10621 ccgcaatttt catggcgtgc atgtagccga gggacccgcc ctgggccagg aagtcggagg
    10681 ccgcgcaggc caccggacgg ccgtccacca ggccgaagcc ggaaacgacg ccgtcgccgg
    10741 ggatttcctt cttgcccatg ccgaagttgt ggcagttgtg gcgcacatgc atgccgattt
    10801 ccgagaaggt gccttcctca aagaggtacc ccatgcggtc gcgggctgtc atttcgccct
    10861 tttcatgtct cttgtcgatc ttttcctgac cgccgctgag gattaccttc ttgcggcggc
    10921 tgttcagatc gtcaatcaat ttgggatcaa tagccattgg tatagtggta tggtgaatag
    10981 ggagaatgtt acttgccgca ttcgcagccg ccggggtgct ggcagaattc ggtcaggacg
    11041 ccgaaggtgc acttgggatg caggaaggtg acctgcgtgt tgtgagcgcc ggggacgggc
    11101 gggtcgttca gcacggtaag gcctgcttcc ttggcctggg agatatttcc ggcgatgtca
    11161 ttggtcttga aagcgatgtg gtggatgcct tccccttttt tctcaatagc cttggcgata
    11221 gcgctttccg gagaggtggg ttcgagcagt tcgatgtgga ctccggcaac gtcaaacatg
    11281 gcgacgcgga ccttttgagt gggaacttcc tcaatgtggg gctctccgag cccgagcgca
    11341 tcgcggtaat aggggacggt ggcgtcaagg ctcttgacgg cgatgccgat atggtcaatt
    11401 tgctgaatca tatgcgtgtg atggttatag ggaatgcagg ggggaggcct gcaatacatc
    11461 aagagttatt aaagcgtatt tttttaggat gtgaagcgaa aagcggaaaa atggcgaatt
    11521 cgtggccgcc cctttcacct gcttgattgc cccggaagat gaggtatggt aggggcatgt
    11581 tcaagagtgg attagccgtg ttatttctgc tggcgtcgtg gttttccgcc tcgtgtgcct
    11641 atgagctgct gcccgctcat gtggccgtgg tttataacgg aaaatccgag ctgagccgcc
    11701 gcatggccag ggagtatgcg cgggtgcgcg gcgttccgga agggaatctc gtttccctgg
    11761 attgccccac gaccagcgag atttcgcgga aggagtatga ggatacgatc cgcgtcccgc
    11821 tgctggaggc ggcgcggaaa caacggtggt gggtgccttc cggcattgcg tcctccccct
    11881 tgatgaaccg gaagattttt gtgctggtgc tgatggcgga cctgccgatg aagatacggc
    11941 atgaaacgcc cgctcccctt cccgggaaag gcgtcaacca gatgcagacg gatcgcgctg
    12001 cggtggattc cgaattggct ctgctggcgg tgggcggtta tgaaaggaag tcctggcagg
    12061 tgaatcccta ttttaataaa agggaggatt ttgtgggttc cggccttcct tcgtttctgg
    12121 tatgccgcct ggacggactg acgcccgata cctgcaggcg gctggtggcg gaaccggcta
    12181 acgtggagaa aaaaggttta tgggggtggg ccgttgtgga ccggggcggc ccctatgccc
    12241 agggggaccg gtggctggac gacgtgttcg agcgcgtaag ggaggcgggc attcccgctt
    12301 atctggatga ctggccccag accctgccgg aaaaattccc cttgagccgg gatacggctc
    12361 tttactgcgg gtggtatgcg gggaatgcga acggaccgtt ttcggatcct tcgttccgct
    12421 tccggcccgg ggcgatagcc atgcatctgc attccttcag cgccgccgat ttcaaggtcc
    12481 ccggcagggg atggagttcc gccctgctgg agaagggggc tgctgtgacg gtgggaaacg
    12541 tgtatgagcc gttcctgggc gcctgccacc gctttgatat ttttgtggac cgcctcctgg
    12601 acggctatac cgtggcggag gcttcctgga tgagcatgcc tgtgctgtcc tggcaggggt
    12661 tggtgttcgg agaccccctg taccgtccat acgcccgcat gaaggatatg gacgtggagc
    12721 cgacggaaga agaccgttat ttccaggggt ggtgggcttc ctccgtgcag ttcggagacc
    12781 gctggaagga ccgttccgcg cgtttgatgg agtccgcccg gaaggcccct ttttcctgcc
    12841 tttatgaagc tctggcgctg gaatgcctgt accggaagga accggcccgc gccggagagc
    12901 tcctttcctc cgccctggcc ggcgcggctg a
//
