Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
1.11
1.12

### Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaKNPJIOME_1 (original name was: gnl|Prokka|KNPJIOME_1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | NRPS | 305,110 | 370,520 | surfactin | NRP:Lipopeptide | 82%
Region 2 | lanthipeptide-class-iii | 771,208 | 793,805 |
Region 3 | PKS-like | 913,606 | 954,850 | butirosin A/butirosin B | Saccharide | 7%
Region 4 | terpene | 1,039,564 | 1,060,307 |
Region 5 | transAT-PKS | 1,357,984 | 1,446,186 | macrolactin H | Polyketide | 100%
Region 6 | transAT-PKS,T3PKS,NRPS | 1,666,784 | 1,776,893 | bacillaene | Polyketide+NRP | 100%
Region 7 | NRPS,transAT-PKS,betalactone | 1,845,336 | 1,981,972 | fengycin | NRP | 100%
Region 8 | terpene | 2,006,338 | 2,028,221 |
Region 9 | T3PKS | 2,083,397 | 2,124,497 |
Region 10 | transAT-PKS-like,NRPS | 2,793,286 | 2,843,179 | bacillothiazol A/bacillothiazol B/bacillothiazol C/bacillothiazol D/bacillothiazol E/bacillothiazol F/bacillothiazol G/bacillothiazol H/bacillothiazol I/bacillothiazol J/bacillothiazol K/bacillothiazol L/bacillothiazol M/bacillothiazol N | NRP | 100%
Region 11 | NRP-metallophore,NRPS | 2,942,363 | 2,994,090 | bacillibactin | NRP | 100%
Region 12 | other | 3,503,944 | 3,545,362 | bacilysin | Other | 100%

gnlProkkaKNPJIOME_1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 305,110 - 370,520 nt. (total: 65,411 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 305109 - 370520:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu - D-Leu) + (Val - Asp - D-Leu) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_313: Glu - Leu - Leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (465..867): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      gln (Gln)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDLGVVDK
    Nearest Stachelhaus code(s):
      Glu DAKDLGVVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1511..1908): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFMMGMVFK
    Nearest Stachelhaus code(s):
      Leu DAFMMGMVFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2550..2939): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code(s):
      Leu DAWFLGNVVK (97% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_314: Val - Asp - Leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (470..864): Val
  nrpys: Val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      val (Val)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWIGGTFK
    Nearest Stachelhaus code(s):
      Val DAFWIGGTFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1502..1904): Asp
  nrpys: Asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asp (Asp)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKVGHIGK
    Nearest Stachelhaus code(s):
      Asp DLTKVGHIGK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2547..2936): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code(s):
      Leu DAWFLGNVVK (97% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_315: Ile
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..867): Ile
  nrpys: Ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      ile (Ile)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGFFLGVVFK
    Nearest Stachelhaus code(s):
      Ile DGFFLGVVFK (88% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaKNPJIOME_1 - Region 2 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 771,208 - 793,805 nt. (total: 22,598 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for ctg1_725

ctg1_727
Leader:
MKDVLELQQLNEGTEVEASKGKGG
Core:
L L T L I T T I V G S S T I S N N C
Core with dehydrations:
L L Dhb L I Dhb Dhb I V G Dha Dha Dhb I Dha N N Cys

#### MIBiG 3.1 matches for ctg1_727

34.8% BGC0002111 (multiple genes): Lanthipeptide: andalusicin A or andalusicin B
9
V G S S T I S N N C
18
V +S T I S N N C
14
V W A S T I S N N C
23
30.4% BGC0002111 (EVG22_32245): Lanthipeptide: andalusicin A or andalusicin B
11
S S T I S N N C
18
+S T I S N N C
16
A S T I S N N C
23

#### antiSMASH-DB 4.0 matches for ctg1_727

100.0% NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
1
L L T L I T T I V G S S T I S N N C
18
L L T L I T T I V G S S T I S N N C
1
L L T L I T T I V G S S T I S N N C
18
94.4% NZ_CP026010.1 and 18 others:
NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide
Lanthipeptides: BS11774_RS22075_lanthipeptide
1
L L T L I T T I V G S S T I S N N C
18
L L T L I T T I V G+S T I S N N C
1
L L T L I T T I V G T S T I S N N C
18
88.9% NC_014551.1 and 27 others:
NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptide NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41670_lanthipeptide
1
L L T L I T T I V G S S T I S N N C
18
L L T L I T T+V G+S T I S N N C
1
L L T L I T T V V G T S T I S N N C
18
with 12 more sequence matches
50.0% NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
2
L T L I T T I V G S S T I S N N C
18
T L+T T++G+S T I S N+C
4
W T L L T T L I G T S T I S N S C
20
50.0% NZ_LN868937.1 and 1 other:
NZ_LN868937.1 Lanthipeptides: BN2144_RS20095_lanthipeptide
Lanthipeptides: BN2144_RS20100_lanthipeptide
1
L L T L I T T I V G S S T I S N N C
18
T+ T T++G+S T I S N N C
4
W Y T I F T T L I G T S T I S N N C
21
45.0% NZ_JAFFJY010000011.1: Lanthipeptides: JVX89_RS12320_lanthipeptide
7
T I V G S S T I S N N C
18
T V G S T I S N C
9
T T V G L S T I S N G C
20
40.9% NZ_LN868937.1: Lanthipeptides: BN2144_RS19915_lanthipeptide
1
L L T L I T T I V G S S T I S N N C
18
T +T +V +S T I S N+C
5
W F T S V T L L V T T S T I S N H C
22
36.4% NZ_CP066711.1: Lanthipeptides: JGZ56_RS07825_lanthipeptide
2
L T L I T T I V G S S T I S N N C
18
L+ + + +G S T I S N+C
6
L S T L L S F L G G S T I S N H C
22
34.8% NZ_CP035727.2 and 5 others:
NZ_CP035727.2 Lanthipeptides: EVG22_RS16230_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16225_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16220_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16215_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16210_lanthipeptide
Lanthipeptides: EVG22_RS16235_lanthipeptide
9
V G S S T I S N N C
18
V +S T I S N N C
14
V W A S T I S N N C
23
33.3% NZ_BMVC01000018.1 and 6 others:
NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptide NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34455_lanthipeptide NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20340_lanthipeptide NZ_JALMDK010000006.1 Lanthipeptides: MZC64_RS26320_lanthipeptide NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567890_1567982_lanthipeptide NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide
Lanthipeptides: IE282_RS34450_lanthipeptide
12
S T I S N N C
18
S T+S N N C
3
S T V S N N C
9
30.8% NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
2
L T L I T T I V G S S T I S N N C
18
+T T++G S T S N+C
10
I T T T R T V I G W S T A S N S C
26
30.4% NZ_CP014806.1 and 3 others:
NZ_CP014806.1 Lanthipeptides: ATY39_RS17975_lanthipeptide NZ_CP014806.1 Lanthipeptides: ATY39_RS17970_lanthipeptide NZ_CP014806.1 Lanthipeptides: ATY39_RS17965_lanthipeptide
Lanthipeptides: ATY39_RS17980_lanthipeptide
9
V G S S T I S N N C
18
V +S T I S N+C
14
V F A S T I S N H C
23
30.4% NZ_CP035727.2: Lanthipeptides: EVG22_RS16240_lanthipeptide
11
S S T I S N N C
18
+S T I S N N C
16
A S T I S N N C
23
26.7% NZ_CM000752.1 and 15 others:
NZ_CM000752.1 Sactipeptides: BTHUR0007_RS37430_sactipeptide NZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15955_sactipeptide NZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15950_sactipeptide NZ_JYPH01000039.1 Sactipeptides: TU52_RS33370_sactipeptide NZ_JYPH01000039.1 Sactipeptides: TU52_RS33365_sactipeptide NZ_NJPZ01000025.1 Sactipeptides: CE087_RS29070_sactipeptide NZ_NJPZ01000025.1 Sactipeptides: CE087_RS29065_sactipeptide NZ_NJPZ01000025.1 Sactipeptides: CE087_RS29060_sactipeptide NZ_NUBO01000020.1 Sactipeptides: CN575_RS31360_sactipeptide NZ_NUBO01000020.1 Sactipeptides: CN575_RS31355_sactipeptide NZ_NUBO01000020.1 Sactipeptides: CN575_RS31350_sactipeptide NZ_NUUQ01000016.1 Sactipeptides: COI65_RS30820_sactipeptide NZ_NUUQ01000016.1 Sactipeptides: COI65_RS30815_sactipeptide NZ_NUUQ01000016.1 Sactipeptides: COI65_RS30810_sactipeptide NZ_NUXK01000018.1 Sactipeptides: COJ27_RS31850_sactipeptide
Sactipeptides: BTHUR0007_RS37435_sactipeptide
1
L L T L I T T I V G S S T I S
15
L L L+T G+S T S
16
L L N L V T A A T G A S T A S
30
26.7% NZ_CP066711.1: Lanthipeptides: allorf_1652598_1652744_lanthipeptide
7
T I V G S S T I S N N C
18
T+ G S T I S N C
14
T V Y G L S T I S N K C
25
ctg1_728
Leader:
MNEVLELQQLSKGSEVE
Core:
T A G W T L L T T L I G T S T I S N S C N K
Core with dehydrations:
Dhb A G W Dhb L L Dhb Dhb L I G Dhb Dha Dhb I Dha N Dha Cys N K

#### MIBiG 3.1 matches for ctg1_728

31.8% BGC0000563 (AEA03263.1): Lanthipeptide: venezuelin
7
L T T L I G T S T I S N S C
20
L T L+ T I S C
8
L L T L L N T V C I G I S C
21
26.1% BGC0002111 (EVG22_32245): Lanthipeptide: andalusicin A or andalusicin B
13
T S T I S N S C
20
S T I S N+C
16
A S T I S N N C
23
26.1% BGC0002111 (multiple genes): Lanthipeptide: andalusicin A or andalusicin B
14
S T I S N S C
20
S T I S N+C
17
S T I S N N C
23

#### antiSMASH-DB 4.0 matches for ctg1_728

100.0% NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
1
T A G W T L L T T L I G T S T I S N S C N K
22
T A G W T L L T T L I G T S T I S N S C N K
1
T A G W T L L T T L I G T S T I S N S C N K
22
63.6% NZ_LN868937.1: Lanthipeptides: BN2144_RS19915_lanthipeptide
1
T A G W--T L L T T L I G T S T I S N S C
20
T A G W T +T L+ T S T I S N C
1
T A G W W F T S V T L L V T T S T I S N H C
22
60.9% NZ_LN868937.1: Lanthipeptides: BN2144_RS20095_lanthipeptide
4
W T L L T T L I G T S T I S N S C N K
22
+T+ T T L I G T S T I S N+C K
5
Y T I F T T L I G T S T I S N N C G K
23
with 10 more sequence matches
59.1% NZ_LN868937.1: Lanthipeptides: BN2144_RS20100_lanthipeptide
4
W T L L T T L I G T S T I S N S C
20
+T+ T T L I G T S T I S N+C
5
Y T I F T T L I G T S T I S N N C
21
54.5% NC_014551.1 and 27 others:
NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_014551.1 Lanthipeptides: BAMF_RS41670_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41675_lanthipeptide
4
W T L L T T L I G T S T I S N S C
20
T L+T T++G T S T I S N+C
2
L T L I T T V V G T S T I S N N C
18
54.5% NZ_CP026010.1 and 18 others:
NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide
Lanthipeptides: BS11774_RS22075_lanthipeptide
4
W T L L T T L I G T S T I S N S C
20
T L+T T++G T S T I S N+C
2
L T L I T T I V G T S T I S N N C
18
50.0% NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
4
W T L L T T L I G T S T I S N S C
20
T L+T T++G+S T I S N+C
2
L T L I T T I V G S S T I S N N C
18
50.0% NZ_JAFFJY010000011.1: Lanthipeptides: JVX89_RS12320_lanthipeptide
3
G W T L L T-T L I G T S T I S N S C
20
G+T T T +G S T I S N C
2
G Y T P T T V T T V G L S T I S N G C
20
40.9% NZ_CP066711.1: Lanthipeptides: JGZ56_RS07825_lanthipeptide
3
G W T L L T T L I G T S T I S N S C
20
G + L + +G S T I S N C
5
G L S T L L S F L G G S T I S N H C
22
40.9% NZ_FOHE01000012.1 and 1 other:
NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20540_lanthipeptide
Lanthipeptides: BMX40_RS20545_lanthipeptide
3
G W T L L T T L I G T S T I S N S C
20
G W T T+ S T+S N C
2
G W T W T V T I F-L S T V S N H C
18
34.6% NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
9
T L I G T S T I S N S C
20
T+I G S T S N S C
15
T V I G W S T A S N S C
26
33.3% NZ_CP066711.1: Lanthipeptides: allorf_1652598_1652744_lanthipeptide
9
T L I G T S T I S N S C N K
22
T+ G S T I S N C N K
14
T V Y G L S T I S N K C N K
27
17.2% NZ_FOHE01000012.1: Lanthipeptides: BMX40_RS20340_lanthipeptide
14
S T I S N S C N K
22
S T+S N+C++
19
S T V S N N C D R
27
ctg1_729
Leader:
MRDVLELQQLNEGTEVEASKGKGG
ctg1_731
Leader:
MRDVLELQQLNEGTEVEASKGKGG
Shared core:
L L T L I T T V V G T S T I S N N C G
Core with dehydrations:
L L Dhb L I Dhb Dhb V V G Dhb Dha Dhb I Dha N N Cys G

#### MIBiG 3.1 matches for ctg1_729

34.8% BGC0002111 (multiple genes): Lanthipeptide: andalusicin A or andalusicin B
9
V G T S T I S N N C
18
V S T I S N N C
14
V W A S T I S N N C
23
30.4% BGC0002111 (EVG22_32245): Lanthipeptide: andalusicin A or andalusicin B
11
T S T I S N N C
18
S T I S N N C
16
A S T I S N N C
23

#### antiSMASH-DB 4.0 matches for ctg1_729

100.0% NC_014551.1 and 21 others:
NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41675_lanthipeptide
1
L L T L I T T V V G T S T I S N N C G
19
L L T L I T T V V G T S T I S N N C G
1
L L T L I T T V V G T S T I S N N C G
19
94.7% NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide
Lanthipeptides: BAMF_RS41670_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T V V G T S T I S N N C
1
L L T L I T T V V G T S T I S N N C
18
94.7% NZ_CP026010.1 and 9 others:
NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide
Lanthipeptides: BS11774_RS22085_lanthipeptide
1
L L T L I T T V V G T S T I S N N C G
19
L L T L I T T+V G T S T I S N N C G
1
L L T L I T T I V G T S T I S N N C G
19
with 22 more sequence matches
89.5% NZ_CP026010.1 and 8 others:
NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide
Lanthipeptides: BS11774_RS22075_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T+V G T S T I S N N C
1
L L T L I T T I V G T S T I S N N C
18
84.2% NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T+V G+S T I S N N C
1
L L T L I T T I V G S S T I S N N C
18
56.5% NZ_LN868937.1: Lanthipeptides: BN2144_RS20095_lanthipeptide
1
L L T L I T T V V G T S T I S N N C G
19
T+ T T++G T S T I S N N C G
4
W Y T I F T T L I G T S T I S N N C G
22
54.5% NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
2
L T L I T T V V G T S T I S N N C
18
T L+T T++G T S T I S N+C
4
W T L L T T L I G T S T I S N S C
20
54.5% NZ_LN868937.1: Lanthipeptides: BN2144_RS20100_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
T+ T T++G T S T I S N N C
4
W Y T I F T T L I G T S T I S N N C
21
45.5% NZ_LN868937.1: Lanthipeptides: BN2144_RS19915_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
T +T +V T S T I S N+C
5
W F T S V T L L V T T S T I S N H C
22
45.0% NZ_JAFFJY010000011.1: Lanthipeptides: JVX89_RS12320_lanthipeptide
7
T V V G T S T I S N N C
18
T V G S T I S N C
9
T T V G L S T I S N G C
20
36.8% NC_016109.1 and 5 others:
NC_016109.1 Lanthipeptides: KSE_RS43700_lanthipeptide NZ_CP068437.1 Lanthipeptides: JK628_RS03400_lanthipeptide NZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptide NZ_CP068437.1 Lanthipeptides: allorf_0778008_0778106_lanthipeptide NZ_CP068437.1 Lanthipeptides: JK628_RS03405_lanthipeptide
Lanthipeptides: KSE_RS43695_lanthipeptide
12
S T I S N N C G
19
S T I S N+C G
2
S T I S N H C G
9
36.8% NC_016109.1: Lanthipeptides: KSE_RS43705_lanthipeptide
12
S T I S N N C G
19
S T I S N C G
2
S T I S N Y C G
9
36.8% NZ_BMVC01000018.1 and 1 other:
NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptide
Lanthipeptides: IE282_RS34450_lanthipeptide
12
S T I S N N C G
19
S T+S N N C G
3
S T V S N N C G
10
36.8% NZ_CP014222.1: Lanthipeptides: VN23_RS10390_lanthipeptide
7
T V V G T S T I S N N C G
19
V S T+S N+C G
2
Q V A D W S T V S N H C G
14
36.4% NZ_CP066711.1: Lanthipeptides: JGZ56_RS07825_lanthipeptide
2
L T L I T T V V G T S T I S N N C
18
L+ + + +G S T I S N+C
6
L S T L L S F L G G S T I S N H C
22
34.8% NZ_CP035727.2 and 5 others:
NZ_CP035727.2 Lanthipeptides: EVG22_RS16230_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16225_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16220_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16215_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16210_lanthipeptide
Lanthipeptides: EVG22_RS16235_lanthipeptide
9
V G T S T I S N N C
18
V S T I S N N C
14
V W A S T I S N N C
23
34.6% NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
2
L T L I T T V V G T S T I S N N C
18
+T T V+G S T S N+C
10
I T T T R T V I G W S T A S N S C
26
33.3% NZ_SMBT01000005.1: Lanthipeptides: EV682_RS11315_lanthipeptide
7
T V V G T S T I S N N C G
19
T S T+S N+C G
1
T P A D W S T V S N H C G
13
31.6% NZ_BMVC01000018.1 and 4 others:
NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20340_lanthipeptide NZ_JALMDK010000006.1 Lanthipeptides: MZC64_RS26320_lanthipeptide NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567890_1567982_lanthipeptide NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide
Lanthipeptides: IE282_RS34455_lanthipeptide
12
S T I S N N C
18
S T+S N N C
3
S T V S N N C
9
31.6% NZ_CP113837.1 and 1 other:
NZ_CP113837.1 Lanthipeptides: OU787_RS28895_lanthipeptide
Lanthipeptides: OU787_RS28905_lanthipeptide
12
S T I S N N C G
19
S T+S N+C G
2
S T V S N H C G
9
31.6% NZ_CP113837.1: Lanthipeptides: OU787_RS28900_lanthipeptide
12
S T I S N N C G
19
S T+S N C G
2
S T V S N Y C G
9
30.4% NZ_CP014806.1 and 3 others:
NZ_CP014806.1 Lanthipeptides: ATY39_RS17975_lanthipeptide NZ_CP014806.1 Lanthipeptides: ATY39_RS17970_lanthipeptide NZ_CP014806.1 Lanthipeptides: ATY39_RS17965_lanthipeptide
Lanthipeptides: ATY39_RS17980_lanthipeptide
9
V G T S T I S N N C
18
V S T I S N+C
14
V F A S T I S N H C
23
30.4% NZ_CP035727.2: Lanthipeptides: EVG22_RS16240_lanthipeptide
11
T S T I S N N C
18
S T I S N N C
16
A S T I S N N C
23
30.0% NZ_CP066711.1: Lanthipeptides: allorf_1652598_1652744_lanthipeptide
7
T V V G T S T I S N N C
18
T V G S T I S N C
14
T V Y G L S T I S N K C
25
13.2% NZ_JAIQCM010000003.1: Lanthipeptides: K9V56_RS08295_lanthipeptide
11
T S T I S N N C G
19
T S T I S C G
33
T S T I S G K C G
41
ctg1_730
Leader:
MRDVLELQQLNEGTEVEASKGKGG
Core:
L L T L I T T V V G T S T I S N N C
Core with dehydrations:
L L Dhb L I Dhb Dhb V V G Dhb Dha Dhb I Dha N N Cys

#### MIBiG 3.1 matches for ctg1_730

34.8% BGC0002111 (multiple genes): Lanthipeptide: andalusicin A or andalusicin B
9
V G T S T I S N N C
18
V S T I S N N C
14
V W A S T I S N N C
23
30.4% BGC0002111 (EVG22_32245): Lanthipeptide: andalusicin A or andalusicin B
11
T S T I S N N C
18
S T I S N N C
16
A S T I S N N C
23

#### antiSMASH-DB 4.0 matches for ctg1_730

100.0% NC_014551.1 and 27 others:
NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptide NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41670_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T V V G T S T I S N N C
1
L L T L I T T V V G T S T I S N N C
18
89.5% NZ_CP026010.1 and 18 others:
NZ_CP026010.1 Lanthipeptides: BS11774_RS22075_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide
Lanthipeptides: BS11774_RS22085_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T+V G T S T I S N N C
1
L L T L I T T I V G T S T I S N N C
18
88.9% NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T+V G+S T I S N N C
1
L L T L I T T I V G S S T I S N N C
18
with 13 more sequence matches
54.5% NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
2
L T L I T T V V G T S T I S N N C
18
T L+T T++G T S T I S N+C
4
W T L L T T L I G T S T I S N S C
20
52.2% NZ_LN868937.1 and 1 other:
NZ_LN868937.1 Lanthipeptides: BN2144_RS20100_lanthipeptide
Lanthipeptides: BN2144_RS20095_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
T+ T T++G T S T I S N N C
4
W Y T I F T T L I G T S T I S N N C
21
45.5% NZ_LN868937.1: Lanthipeptides: BN2144_RS19915_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
T +T +V T S T I S N+C
5
W F T S V T L L V T T S T I S N H C
22
45.0% NZ_JAFFJY010000011.1: Lanthipeptides: JVX89_RS12320_lanthipeptide
7
T V V G T S T I S N N C
18
T V G S T I S N C
9
T T V G L S T I S N G C
20
36.4% NZ_CP066711.1: Lanthipeptides: JGZ56_RS07825_lanthipeptide
2
L T L I T T V V G T S T I S N N C
18
L+ + + +G S T I S N+C
6
L S T L L S F L G G S T I S N H C
22
34.8% NZ_CP035727.2 and 5 others:
NZ_CP035727.2 Lanthipeptides: EVG22_RS16230_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16225_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16220_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16215_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16210_lanthipeptide
Lanthipeptides: EVG22_RS16235_lanthipeptide
9
V G T S T I S N N C
18
V S T I S N N C
14
V W A S T I S N N C
23
34.6% NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
2
L T L I T T V V G T S T I S N N C
18
+T T V+G S T S N+C
10
I T T T R T V I G W S T A S N S C
26
33.3% NZ_BMVC01000018.1 and 6 others:
NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptide NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34455_lanthipeptide NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20340_lanthipeptide NZ_JALMDK010000006.1 Lanthipeptides: MZC64_RS26320_lanthipeptide NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567890_1567982_lanthipeptide NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide
Lanthipeptides: IE282_RS34450_lanthipeptide
12
S T I S N N C
18
S T+S N N C
3
S T V S N N C
9
33.3% NZ_CP068437.1 and 1 other:
NZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptide
Lanthipeptides: JK628_RS03400_lanthipeptide
12
S T I S N N C
18
S T I S N+C
5
S T I S N H C
11
31.6% NZ_CP014222.1: Lanthipeptides: VN23_RS10390_lanthipeptide
7
T V V G T S T I S N N C
18
V S T+S N+C
2
Q V A D W S T V S N H C
13
30.4% NZ_CP014806.1 and 3 others:
NZ_CP014806.1 Lanthipeptides: ATY39_RS17975_lanthipeptide NZ_CP014806.1 Lanthipeptides: ATY39_RS17970_lanthipeptide NZ_CP014806.1 Lanthipeptides: ATY39_RS17965_lanthipeptide
Lanthipeptides: ATY39_RS17980_lanthipeptide
9
V G T S T I S N N C
18
V S T I S N+C
14
V F A S T I S N H C
23
30.4% NZ_CP035727.2: Lanthipeptides: EVG22_RS16240_lanthipeptide
11
T S T I S N N C
18
S T I S N N C
16
A S T I S N N C
23
30.0% NZ_CP066711.1: Lanthipeptides: allorf_1652598_1652744_lanthipeptide
7
T V V G T S T I S N N C
18
T V G S T I S N C
14
T V Y G L S T I S N K C
25

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_727 - Class III
  Cleavage pHMM score: 0.00
  RODEO score: 0
  Monoisotopic mass: 1723.0 Da
  Molecular weight: 1724.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1742.0 Da N = 1
    1760.0 Da N = 2
    1778.1 Da N = 3
    1796.1 Da N = 4
    1814.1 Da N = 5
    1832.1 Da N = 6
ctg1_728 - Class III
  Cleavage pHMM score: -1.30
  RODEO score: 0
  Monoisotopic mass: 2119.2 Da
  Molecular weight: 2120.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2138.4 Da N = 1
    2156.4 Da N = 2
    2174.4 Da N = 3
    2192.5 Da N = 4
    2210.5 Da N = 5
    2228.5 Da N = 6
    2246.5 Da N = 7
    2264.5 Da N = 8
ctg1_729 - Class III
  Cleavage pHMM score: 0.00
  RODEO score: 0
  Monoisotopic mass: 1780.0 Da
  Molecular weight: 1781.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1799.1 Da N = 1
    1817.1 Da N = 2
    1835.1 Da N = 3
    1853.1 Da N = 4
    1871.2 Da N = 5
    1889.2 Da N = 6
ctg1_730 - Class III
  Cleavage pHMM score: 0.00
  RODEO score: 0
  Monoisotopic mass: 1723.0 Da
  Molecular weight: 1724.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1742.0 Da N = 1
    1760.0 Da N = 2
    1778.1 Da N = 3
    1796.1 Da N = 4
    1814.1 Da N = 5
    1832.1 Da N = 6
ctg1_731 - Class III
  Cleavage pHMM score: 0.00
  RODEO score: 0
  Monoisotopic mass: 1780.0 Da
  Molecular weight: 1781.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1799.1 Da N = 1
    1817.1 Da N = 2
    1835.1 Da N = 3
    1853.1 Da N = 4
    1871.2 Da N = 5
    1889.2 Da N = 6

gnlProkkaKNPJIOME_1 - Region 3 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 913,606 - 954,850 nt. (total: 41,245 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
NRPS/PKS substrates
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

gnlProkkaKNPJIOME_1 - Region 4 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,039,564 - 1,060,307 nt. (total: 20,744 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaKNPJIOME_1 - Region 5 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,357,984 - 1,446,186 nt. (total: 88,203 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 1357983 - 1446186:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:
  ctg1_1350 + ctg1_1351 + ctg1_1352 + ctg1_1353 + ctg1_1354 + ctg1_1355 + ctg1_1356

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1349: mal
  PKS_AT (4..282): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 75.0%
    inactive: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 82.2
    Methoxymalonyl-CoA: 28.9
    inactive: 28.3
    Methylmalonyl-CoA: 19.0
    Propionyl-CoA: 13.6
    fatty_acid: 11.1
    trans-1,2-CPDA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

gnlProkkaKNPJIOME_1 - Region 6 - NRPS,T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,666,784 - 1,776,893 nt. (total: 110,110 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 1666783 - 1776893:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1604: mal
  PKS_AT (4..285): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 87.5%
    inactive: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 98.2
    inactive: 43.3
    Methoxymalonyl-CoA: 36.6
    Methylmalonyl-CoA: 24.6
    Propionyl-CoA: 24.5
    2-Methylbutyryl-CoA: 5.7
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg1_1605: mal
  PKS_AT (7..293): mal
  ATSignature: (unknown)
  No matches above 50%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 29.5
    inactive: 16.6
    Methoxymalonyl-CoA: 11.9
    Benzoyl-CoA: 9.4
    Isobutyryl-CoA: 8.6
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg1_1606: mal
  PKS_AT (4..282): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 91.7%
    inactive: 66.7%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 96.9
    inactive: 30.8
    Methoxymalonyl-CoA: 27.7
    Methylmalonyl-CoA: 15.2
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg1_1611: pk - Gly
  Search NORINE for peptide: strict or relaxed
  CAL_domain (74..476): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 21.9
    shikimic_acid: 0.0
    NH2: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  AMP-binding (1145..1540): Gly
  nrpys: Gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
    Single AA prediction:
      gly (Gly)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGMIWK
    Nearest Stachelhaus code(s):
      Gly DILQLGMIWK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_1614: Ala
  Search NORINE for peptide: strict or relaxed
  AMP-binding (494..898): Ala
  nrpys: Ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVSNMAIIYK
    Nearest Stachelhaus code(s):
      Ala DVSNMAIIYK (88% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaKNPJIOME_1 - Region 7 - NRPS,betalactone,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,845,336 - 1,981,972 nt. (total: 136,637 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 1845335 - 1981972:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile) + (mal - Asn) + (D-Tyr - D-Asn - Gln - Pro) + (D-Asn - Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 1845335 - 1922581:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal - Asn) + (D-Tyr - D-Asn - Gln - Pro) + (D-Asn - Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 1904313 - 1981972:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1738: Asn - Ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (268..663): Asn
  nrpys: Asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asn (Asn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code(s):
      Asn DLTKIGEVGK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1778..2185): Ser
  nrpys: Ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      ser (Ser)
    Single AA prediction:
      ser (Ser)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLIDK
    Nearest Stachelhaus code(s):
      Ser DVWHFSLIDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_1739: Tyr - Asn - Gln - Pro
  Search NORINE for peptide: strict or relaxed
  AMP-binding (268..662): Tyr
  nrpys: Tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
    Small clusters prediction:
      Polar aromatic ring (Tyr, bOH-Tyr)
    Single AA prediction:
      tyr (Tyr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALSVGEVVK
    Nearest Stachelhaus code(s):
      Tyr DALSVGEVVK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1778..2173): Asn
  nrpys: Asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asn (Asn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code(s):
      Asn DLTKIGEVGK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (3287..3692): Gln
  nrpys: Gln
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      gln (Gln)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAQDLGVVDK
    Nearest Stachelhaus code(s):
      Gln DAQDLGVVDK (100% 8Å match)
      Ile DAQDLGVVDK (74% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (4334..4730): Pro
  nrpys: Pro
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
    Small clusters prediction:
      pro (Pro)
    Single AA prediction:
      pro (Pro)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVQFIAHVVK
    Nearest Stachelhaus code(s):
      Pro DVQFIAHVVK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_1740: pk - Asn
  Search NORINE for peptide: strict or relaxed
  CAL_domain (36..478): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 609.5
    NH2: 18.8
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  AMP-binding (2956..3351): Asn
  nrpys: Asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asn (Asn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code(s):
      Asn DLTKIGEVGK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_1741: mal
  PKS_AT (6..291): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 62.5%
    inactive: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 75.6
    inactive: 33.5
    Methoxymalonyl-CoA: 20.3
    Propionyl-CoA: 13.0
    Methylmalonyl-CoA: 11.3
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg1_1759: X
  AMP-binding (12..445): X
  nrpys: Asp, Asn, Glu, Gln, Aad
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      -GLHIAAPVK
    Nearest Stachelhaus code(s):
      Z-ahmohOrn FGLHIASTCK (56% 8Å match)
      Ile DGLFIGIPVK (32% 8Å match)
    Stachelhaus code match:
      60% (weak)
ctg1_1763: Ile
  Search NORINE for peptide: strict or relaxed
  AMP-binding (473..866): Ile
  nrpys: Ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      ile (Ile)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFFYGITFK
    Nearest Stachelhaus code(s):
      Ile DAFFYGITFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_1764: Pro - Gln - Tyr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..866): Pro
  nrpys: Pro
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
    Small clusters prediction:
      pro (Pro)
    Single AA prediction:
      pro (Pro)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVQFIAHVVK
    Nearest Stachelhaus code(s):
      Pro DVQFIAHVVK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1500..1901): Gln
  nrpys: Gln
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      glu (Glu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGSVEK
    Nearest Stachelhaus code(s):
      Gln DAWHFGSVEK (100% 8Å match)
      Glu DAWHFGSVEK (94% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2532..2924): Tyr
  nrpys: Tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
    Small clusters prediction:
      Polar aromatic ring (Tyr, bOH-Tyr)
    Single AA prediction:
      tyr (Tyr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGTITAEVAK
    Nearest Stachelhaus code(s):
      Tyr DGTITAEVAK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_1765: Glu - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (468..873): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      glu (Glu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGGVDK
    Nearest Stachelhaus code(s):
      Glu DAWHFGGVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1505..1898): X
  nrpys: Ala, Val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      val (Val)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVFWIGGTFK
    Nearest Stachelhaus code(s):
      Ala or Val DVFWIGGTFK (97% 8Å match)
      Val DVFWIGGTFK (94% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_1766: Tyr - Thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (473..866): Tyr
  nrpys: Tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
    Small clusters prediction:
      Polar aromatic ring (Tyr, bOH-Tyr)
    Single AA prediction:
      tyr (Tyr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGTLTAEVAK
    Nearest Stachelhaus code(s):
      Tyr DGTLTAEVAK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1508..1904): Thr
  nrpys: Thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      thr (Thr)
    Single AA prediction:
      thr (Thr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code(s):
      Thr DFWNIGMVHK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_1767: Glu - Orn
  Search NORINE for peptide: strict or relaxed
  AMP-binding (464..868): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      glu (Glu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGGVDK
    Nearest Stachelhaus code(s):
      Glu DAWHFGGVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1500..1905): Orn
  nrpys: Orn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Long positively charged side chain (Orn, Lys, Arg)
    Small clusters prediction:
      Orn and hydroxy-Orn specific (Orn, OH-Orn)
    Single AA prediction:
      orn (Orn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVGEVGSIDK
    Nearest Stachelhaus code(s):
      Orn DVGEVGSIDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaKNPJIOME_1 - Region 8 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,006,338 - 2,028,221 nt. (total: 21,884 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaKNPJIOME_1 - Region 9 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,083,397 - 2,124,497 nt. (total: 41,101 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

NRPS/PKS substrates
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

gnlProkkaKNPJIOME_1 - Region 10 - NRPS,transAT-PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,793,286 - 2,843,179 nt. (total: 49,894 nt) Show pHMM detection rules used
transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 12, location 2793285 - 2843179:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Cys) + (Cys) + (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 13, location 2793285 - 2836030:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Cys) + (Cys) + (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 14, location 2796080 - 2843179:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Cys) + (Cys) + (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2682: pk
  CAL_domain (33..470): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 219.3
    NH2: 10.0
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
ctg1_2685: Cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (324..715): Cys
  nrpys: Cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Polar, uncharged (aliphatic with -SH) (Cys)
    Small clusters prediction:
      Polar, uncharged (aliphatic with -SH) (Cys)
    Single AA prediction:
      Polar, uncharged (aliphatic with -SH) (Cys)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code(s):
      Cys DLYNLSLIWK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_2686: Cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (560..951): Cys
  nrpys: Cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Polar, uncharged (aliphatic with -SH) (Cys)
    Small clusters prediction:
      Polar, uncharged (aliphatic with -SH) (Cys)
    Single AA prediction:
      Polar, uncharged (aliphatic with -SH) (Cys)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code(s):
      Cys DLYNLSLIWK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaKNPJIOME_1 - Region 11 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,942,363 - 2,994,090 nt. (total: 51,728 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 15, location 2942362 - 2994090:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2825: Gly - Thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (456..855): Gly
  nrpys: Gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
    Single AA prediction:
      gly (Gly)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGLIWK
    Nearest Stachelhaus code(s):
      Gly DILQLGLIWK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1513..1929): Thr
  nrpys: Thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      thr (Thr)
    Single AA prediction:
      thr (Thr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code(s):
      Thr DFWNIGMVHK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_2827: diOH-Bz
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..435): diOH-Bz
  nrpys: diOH-Bz
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
    Small clusters prediction:
      Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
    Single AA prediction:
      dhb (diOH-Bz)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPAQGVVNK
    Nearest Stachelhaus code(s):
      diOH-Bz PLPAQGVVNK (97% 8Å match)
      diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaKNPJIOME_1 - Region 12 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,503,944 - 3,545,362 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (LmbU or Neocarzinostat or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.