LOCUS       gnlProkkaHGBGCOMN_59   10721 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HGBGCOMN_59.
ACCESSION   gnlProkkaHGBGCOMN_59
VERSION     gnlProkkaHGBGCOMN_59
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 02:20:54
            Original ID  :: gnl|Prokka|HGBGCOMN_59
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10721
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10721
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1407:5721]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1408..5721
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10721
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10721
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..185
                     /locus_tag="ctg59_1"
                     /transl_table=11
                     /translation="MNGQVTKVKGSGKKQIEPGCEIIVPSKAKKKGNIANILGYATSFS
                     SLGMMIASIANLIKK"
     CDS             196..1344
                     /locus_tag="ctg59_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1408..2127
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.7e-14, bitscore:
                     44.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMRTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2148..3449
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_4"
                     /sec_met_domain="CTP_transf_like (E-value: 3.1e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.2e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.6e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             3466..4590
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.7e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4600..5721
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg59_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_6"
                     /sec_met_domain="Aminotran_5 (E-value: 2.4e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4690..5697
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg59_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg59_6_Aminotran_5.1"
                     /locus_tag="ctg59_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5718..5861
                     /locus_tag="ctg59_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             6064..7548
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg59_8"
                     /sec_met_domain="Polysacc_synt (E-value: 2.1e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7502..8761
                     /locus_tag="ctg59_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8770..9519
                     /locus_tag="ctg59_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             9519..10559
                     /locus_tag="ctg59_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 acatgaatgg tcaggtgacg aaggttaagg gtagtggtaa gaaacagatt gagccgggat
       61 gtgagattat tgtgcctagt aaggctaaga agaaagggaa catagctaat attttaggtt
      121 atgctacttc cttcagttct ttgggaatga tgattgcttc tattgctaat ttgataaaga
      181 aataaatgac ctattatgat tgaaaagcaa tcttatcaag aaccgttttc tgaagtggat
      241 aaaaggaaag atgatgaaat ggaaatagac ttgatggcta ttttttataa gattattact
      301 gttcgtggag tactatgcaa agctgctgga gtgggagtaa taattgctat agtggtggca
      361 ttgagcattc ccaagcaata tacagtaaag gttacccttt ctcctgaaat gggtaatgcg
      421 aagggaagta atggtttagc cggacttgct gcctcgtttt tgggagatgg ggctctaata
      481 ggggaaagca cagatgcctt gaacgcttct ctttcagcag atattgtttc ttcaactcct
      541 tttttattgg aacttttaga aatggaagtc tccgtttcta aaaaggatga taaaatgact
      601 ttggggtctt atctcgatga agagtcatct ccttggtggg attatcttat aggttttccg
      661 ggcatagtaa taggaggagt taaatcatta ttcggagaag atacggttcc tgccagtgga
      721 gggcggcaag gaactatcga attgacgaaa gaagtaaatg agaagattaa ttttcttaaa
      781 aagaagatta gtgcatccat tgataagaaa accgccataa cgagcattac ggtcacctta
      841 caaaatccgc agatcactgc ggttatagca gattctgtcg ttcataaatt acaggaatat
      901 attattgggt atcgaacttc aaaagtaaaa gaagactgtg cgtatttgga acggttgttt
      961 aaagaacgtc agcaggaata ttatgctgct caaagaaaat atgcggatta tgtagacgcc
     1021 catgataatg tggttcttca aagtgtacgt gctgagcagg agcgtttaca gaacgacatg
     1081 agtttggctt atcagatata tagtcaggtt gctaatcagt tgcaggtatc cagagccaaa
     1141 gtacaggagg aaaagccagt ctttgcagta gttgagcctg ccgttgtacc tttgaaacct
     1201 tcaggtatgg gactcaaaat ttatatttta ttatttgtgt tcctgtccgt atctggtact
     1261 ctcgtgtggg tgttttttgg caaaagtctg ctggctagct tgagaaaaga actgaaaaat
     1321 aaggagatag aacaggataa atgatgctaa aacgtcgttt acaacattct tacatcaatt
     1381 aaattcactt actatattat taaacgaatg atacgtacag ctatgataat ggctgcgggc
     1441 atgagaaccc gttttggcca atatacagaa ttgataccta aagggttcgt caaagtggga
     1501 ggtattccaa tgatagttcg ttctattgat actttgttat catgtgacat tgagcgaatt
     1561 gtaatcggta caggatataa acaagaagtt tatgaagaat tgaagacaga ctatcctatg
     1621 cttgaaacct gttttagtcc tcgttatgct gaaacaaata gtatgtatac tttatataat
     1681 acgcgggaga ttctgggcaa tgatgatttt ttattgttag agtcagattt gatttttgag
     1741 aaacaagcaa taatgagctt attggagtgt cctgcggcag atgcaatgct aataactcca
     1801 gtgacaaagt ttcaagatca gtattatgtg gaacatgatg ataattttcg cctttcttca
     1861 tgttctgtca ataagaataa actaaacgct aaaggcgaat tggtcggcat ccataaacta
     1921 tccggttcct tttacaaaat aatgtgtgct gattatgcga gtattgttga tgaacaaccc
     1981 aatttgggat atgagtatga attactacga atatcttgtt ctcaatctcc tgtttatgtg
     2041 cataaagtag aagggctgaa atggtatgaa atcgatgaca tatcagattt ggaatatgca
     2101 gagaaatata ttgttccgta ttgttaatta aaataatata tcaaattatg agtaagacag
     2161 tttatattgg gatgactgcg gatattatgc atccaggact tatccgcatt attaatgagg
     2221 ctactaaata cggtgatgtt ataattggtc ttcttacaga taaagctatt gcggagcata
     2281 aacgccttcc ttatctgacc tatgaacaac gaaaagaggt agttcagaat attaaaggcg
     2341 tatgtaaagt tgttcctcaa gaagaatgga gctatgttga gaatctcaaa cgcattaaac
     2401 ctgactatat aattcatggt gacgactgga aaaccgggcc tttacgtgaa gaacgtgtgc
     2461 gcgtatttga agtgatgaat gaacagggag gaaaggttat cgaaattcca tatactttgg
     2521 gaattaattc atcttctttg gataaagata ttaaggctat aggtacaacc cctgatgtac
     2581 gtttaaaatc acttcgtcgt ttgataaatg ccaaacccgt agttcgtatt ttggaagctc
     2641 atgatggact atgtggcttg ataattgaaa atcaggaaat attaaaaggg gataagaggg
     2701 aagtatttga cggaatgtgg tctagtagcc ttacggattc aaccagtaaa ggtaaacctg
     2761 atattgaggc ggttgattta actacccgat tgcaagattt gaataatatt ctggagtgta
     2821 ctactaaacc tattattttt gatggagata caggtggtaa aattgaacat ttcgtattta
     2881 cagtacgcac tttagaacgt catggaattt cagctataat aattgaagat aaagttggat
     2941 taaaaaagaa ttcattgttt ggtacagatg ttattcaaac tcaagataca atcgaaggtt
     3001 tctgtaataa gatcaaagca ggaaaggcat ctcagattac tgatgatttt atgattatcg
     3061 ctcgtattga gagccttata gcgggaaagc cggtaagtga tgctttagag agagcttttg
     3121 catatgtcca agcgggagcg gacggtatta tgatacatag caaaaataag tcgggtgaag
     3181 atataaaaga attttgtttg gcgtttcgaa aacagtatgc tcatgtacct atcgtggttg
     3241 tgcctactac atatgatcat atttatgagt ctgaattgtg tgattggggt gtgaatataa
     3301 ttatttatgc taatcatatg cttcgtgccg cttatcctgc tatgatgaat gtcgcaaaga
     3361 taatattaga gaatgaacgt gctttagagg tgcgcgaact gtgtatgccc ataaaagaaa
     3421 tattggaact gattccaggt actaaataaa aagaggaata tcattatgtt aagcgtagaa
     3481 aaagtttatg aaacgtttct gagtcatgac gttgattttt ttacaggagt tccagactca
     3541 ttactaaaaa atatttgtgc ctatatcaca gaccatactt cacgtgagaa acatatcata
     3601 gctgctaatg aaggtgcggc tgtaggaatt gcttcaggtt attatatggc atcaggtaag
     3661 gttcctgtgg tttatatgca aaattccggc ttgggtaata ctgttaatcc tctgctgtct
     3721 cttgcagatg aacaagtata cagttttcca atgcttttga tgattggctg gcgtggtgaa
     3781 ccgggaacaa aagatgaacc tcagcataaa aaacagggtg aggtaacttt agatttgttg
     3841 aaagcaatgc ggattcctta tataattctt gattcaaatg agaatgatgc atttattcag
     3901 ctccatgata tcatacaatc agcaaaaact aagaatattc ctcatgcaat aattattcgg
     3961 aaagatgttt ttggcaaata taaacttcaa aaagagttcg gatgtaatta tcctttatct
     4021 cgtgaggatg ctttgcaaat agttgtggat tatctgcctg aaaattcagt ggtcgtttct
     4081 actactggca agctttctcg tgagttattt gaatatcgag aaatgaaaga gcaaggtcat
     4141 gaacatgatt ttctcacggt aggctctatg ggacatagtt catcaatctc tttgggtatt
     4201 gctatagcaa agcaagatag acctgtttat tgcttggatg gtgatggagc atttattatg
     4261 catttagggg caattagtaa cattggcgat ttatctccta aaaactatta tcatattttg
     4321 tttaacaatg gtgctcacga gtctgtagga ggacagccta ctttaggatt tagtttagat
     4381 attccggcta ttgtccgggg gagcggatat aagcatactt atactgtttg tacaaaagtt
     4441 gaaattgaag aagcaatgaa gcagcttcca aagttatgtg gtcctgtttt gttggaaata
     4501 aaggttaaaa tagattctcg ggagaatttg ggacgtccca cgactactcc tatagagaat
     4561 aaggagcatt ttatggattt tttaaaataa atatattcga tgaaaataga aagaaaaata
     4621 ttattaaatc ctgggcctgc cactactact gacagtgtaa aaatggcaca agttgttccg
     4681 gatatttgtc ctcgcgagaa agaattcgca ggtatgatga aacaacttcg ggacgatttg
     4741 gtcagagttg ctcatgggaa tttggaaaaa cataccgctg tattattttg tggctcagga
     4801 accatcaata ttgatatatg tctaaattct cttcttcctg aagacaaaag ggtgcttata
     4861 gtgaataatg gggcatatag tacccgtgct gtagaagtgt gtcaatatta tggtttgcct
     4921 catattaatt tggaattttc cgtttacgaa cgtcctgatt tatcggtggt ggaaaatgtg
     4981 ttgcaagaaa atcctgatat agctatggtt tatactactc atcacgagac gggtacagga
     5041 attctgaacc ctattcgcga gatgggcgct atagctcata aatatcaggc taaatttgtc
     5101 gtcgatacta cttcttcttt gggcatgatt ccttttgata tagagaaaga taatgtggat
     5161 ttttgtatgg catctgctca aaaaggactt caagcgatga caggtctttc ttttattata
     5221 ggcaatgagg aacagattaa gttttcaaaa aaatatccca agcgttctta ctattgtaat
     5281 ctttatttgc agtatgagaa ttttgagaga acaggtgaaa tgcattttac tccaccggta
     5341 caaactattt acgccactcg tcaggcatta aatgaatatt ttgaagtggg tgaagaagct
     5401 aagtttgccc gtcacaaaag agtttttgag gctattcatt caggtataaa tgaaattggt
     5461 cttaaaagtg taataaagcg tgaatggcag tcaggactgg ttgtctcagt tcaataccca
     5521 gaagatccca actgggattt tgagaaaata catgattatt gttatgagcg tggatttacg
     5581 atttatccag gtaagatatc aactgaggat acttttagaa tctgtgcttt aggagagata
     5641 gaagtagatg atattgagaa cttctttaaa gtactaaaag ctgcattaaa tcattataac
     5701 gtcacattac cgatgtcatg attgcagaaa tattattgaa gattcgtcat ttttattttt
     5761 cccttcgtgg tatacacttc catccggaaa gtgttatttc tggagtgcct attcgtagct
     5821 ttcgcttagt aggcaaatat ggcaatatta atttgaggtg atgcattagg agttctttat
     5881 tcttataaaa aggcatcggt agttatagga gataatgttt gtgtagggta atttgctttt
     5941 agtgggagag accatattag aattgcggta aggggcgaag aagataataa ccaattagtg
     6001 agaatattgg aaaaatataa ttgatatcgg taaatgtagt tgtttttata ctgtatttaa
     6061 gtaatggaaa atctaaagca gaaaactgta tcaggaataa tgtggagcgc tatagaacgt
     6121 ttctctttac aaggagtaca gtttataatt caaataatat tagctcgttt gttactacca
     6181 tcggattatg gtatgatcgg gatgttagct atttttcttc aagtcgctca agtatttata
     6241 gatagcggtt ttacaaatgc tttaatccag aaaaaagata gaactgaaga ggattttgcc
     6301 actgtctttt attttaatat tcttgtcgca gtattattct atggtatatt gtttttttcg
     6361 gcttctttga ttgcagactt ttataatatg ccgactttag ttcttgtaat tcgttttata
     6421 gcattgtcgt tgataataaa tgctttatcg gctattcaca gaacgaaatt aattatttct
     6481 gtaaacttta aaactcaatc taaaatttca ttaggtgcag cttttatatc aggcgtgatt
     6541 ggaatatgga tggcttatgt cggttgcggg gtttgggctt tagtttggca aactctctta
     6601 aatagtataa ttttgacaat tttgttttac tgtttagttc attggaaacc tttacatact
     6661 ttctccaaaa gttcttttga aagattattc aatttcggat ctaaattatt gatctcaagt
     6721 cttatcaata cagtatatcg taatctgtat accattgtaa taggaaaaaa gttttctgtt
     6781 gtagagcttg gttactatac aagagcagaa caatttgcta tttttccttc caataattta
     6841 aatgctttag tttctagagt agcgtatcct attttaagtt ccattcaaga tgatgataaa
     6901 tgtttaacaa acgcatatcg aaattatatc agattatcct catatataat ttttccttta
     6961 atggtaggtt tacttgtttt ggctaatcct attattagtc tattgttaac agataaatgg
     7021 tctggggttg ttattctttt acagatatta tgtttggatt ggatgtttga tcatttgagc
     7081 caaattaatt tgaatttatt atgggttaaa ggaagatctg atctgtcgtt acgtcttgaa
     7141 ataataaaaa agacgattgc tatattcatt ctttttgtgt caattccatt tgggcttgag
     7201 gtgatgtgtt ggggtagagt tatttactct ctgatagcga catatttgaa tacatattat
     7261 actaattctc ttattgattt gaccttaaag ttgcaagtta aagatgtatt tccaagttta
     7321 atactctctt tcataatggg ggggatcgtt tttatatgta tttctttctt tgaaactgat
     7381 atagtaaaaa ttgtgattgg atgtattact gggatgtcct tctatatttt actttctttt
     7441 ctttttaagc tagattcttt tttttgtatt ttaacattga tcattaaaac taaaaacata
     7501 gatgaaaata ttaaaaaaga tttttcaagt aatagtaaag ataattaacc attgtgtgcc
     7561 agttgatagt agatcattgt attttattcc tcatcctaat tgtagaacag ataaatatga
     7621 tattataaat tattcgtcag ataatgttct cgttctgtta aattatttgc taaaaaaaga
     7681 tagtgctgaa tattataaaa tatatgttga aatttatgat tcttctcgta tttcagaata
     7741 tcaagaatat atttatggca taaatcctaa tattaggtgt acttttttat gtgcatgtgt
     7801 tggacgtttt ttctttaata aagtatcttt taaggatatg ttgtatgcct ttttttgttt
     7861 ttgtagagca agtaaatgtt ttacagctac tttttattat gatttttcat ttaaaaaacg
     7921 ctctcaacag attatttgtt tggggtatta tactccattc aaagatgatt atcatatggg
     7981 agatcattct tatgataaat ttcgtaatac aacatgtaac tcatttgatt actctattgc
     8041 tacttcttgt ttaagtgcta gaataatttc aatagattgt ggaatctcat atgataaatt
     8101 caaagtctta ggatttccca gaaatgattt gttgatatcg aaaaataatt gcaatgttat
     8161 taaaagagaa atttcgaaat ttgcgggata tgatgtaact aaatatatag tttatactcc
     8221 aacttttcgt gattatgaga ctgttactga aggtaatttg cgttcaatac tcggatatgt
     8281 tgattgtgat ttgttgaagt tatcgaaaat actattgaag tttaatgcgg ctttaattct
     8341 taaattacat cctttgcaga ataaaacagt cttaaaaaaa gatttaccca aaggtatact
     8401 tgtttttgaa caaacatata aatatggatt gtatgatctt ttgtcatttt cagatggaat
     8461 gattactgat tatacttcta cctattttga ttttttattg gtaaataagc cagtcatatt
     8521 taatttctac gatattgaag aatatcgtag agtaagaggt ttctcatttg agccaataga
     8581 atttttttgt gcaggtgata ttgtttacaa ttataatgaa ttgatagatg ctgtgatggg
     8641 acttctggct gggaaagata ttcatgctga acatcgacgt catatttctt tattgatgaa
     8701 tcaatttcaa gatgataatt caacaaagag aatatgtgac atatttttaa atgaaatata
     8761 ataaataaaa tgaattatgc atttgtggtg caggcacgtt taggttctac acgtttgcct
     8821 ggaaaaatat tgaaaccttt ctatggtaat caatcgattc ttgacttaat ggttcataag
     8881 ctttctgcta tatcgaatat tccagtaatt attgctacaa caaattctgt tatcaatgaa
     8941 cctattgaaa agaaggcact tgcattaggg gtaaagtgct tcagaggtga ggagaatgat
     9001 gttttaaaac gattcattga tgttgctgaa tattttgata tacagggtat attccgaata
     9061 tgttctgata atccattttt agatgtacat gcggcaaggc aattggtcga aatagcaatg
     9121 aaatcttgta acgattatat aagttttgat attgatggta ctccatcaat taaaactcat
     9181 ttcggttttt ggggagaatt tgtaacgctt gatgcgctga agcgagttat aggatttact
     9241 gatgatttat tgtatcgtga acatgttact aattatatat atagtcatcc tgaacttttt
     9301 aatattcaat ggatttcagg atctccagtc gtgtcaaaac atcataatat tcgactcacg
     9361 attgatacgt tagaagattt ttctgtagca cagagaatat atagggattt acaagaaaaa
     9421 agagtggaaa tatcgataga agtgattgta gactatgttc gaagacatgc agaatacatt
     9481 caactgatga aacaacaaat aaaaaaaaat tctaaataat gaagaatact tatattattg
     9541 gtgaaatagg gcagaatcat aatggttctg ttgacttggc taagttgatt attgaattaa
     9601 tctcacgacc tgtacatgag gatgtttttg gtatggattt catgccaatg aatgctgtta
     9661 aaatgactaa aagagattta tcagaagaat tggctgtttc tcaaatgaat caaatatatg
     9721 acaatcctaa ttcttttggg cgtacttatg gtgaacatcg tgcttttctt gagcttgatg
     9781 atcaagcgca ttttgagatt tataaatatg ctaagtcatt aggattagat tttatcgaga
     9841 cgttatgtgc caaaggatgt ctgtctttgc ttaaactgtt cacaccggat aggctaaaag
     9901 ttgctagtcg tgatttgact aacttaccat tgcttgaagc attagcagaa actcatattc
     9961 ctattatatt atcgacagga atggctggtc aaagagaact tgacaatgca ttagatgtga
    10021 taacgagata tcatagtaat atagctattc tacattgtgt atctcagtat ccaactcatc
    10081 caaataattt gaatctacgt acaataacat atttgaagaa gcattacaat aagtttgaga
    10141 taggtttttc tgatcataca ataggtattt ctgctgctac agctgctgta gcgatgggag
    10201 cggaaattat agaaaagcat gtaacaattg atcggcatat gaaaggaaca gaccagcttg
    10261 gctctttagg tccagatggg gttaatcgta tgattcgaga tattcgcata gcagagtgtt
    10321 ggcttggtac tgaagatctt tatatagaaa aaggggtgga gaagtctaag ataaaacttg
    10381 aacgttctat tgccactcga aaatatattc cagcaggtag tattattcaa gagtcggaca
    10441 ttcatttact gagtcctggt gatggttata aatggataga taaaaaaaat gtaattggtc
    10501 attttgctaa acaagatata tcagcgaatg aaataatata tcctgatttt attgaataga
    10561 tatattccta ctgcaacttg tattacggta tagagtactg cctgctataa gctaagtagt
    10621 gattaataaa taagggtaaa atactaaaaa aatgaaagag ataaagctta tacttacaga
    10681 tattgatggc gtttggactg atggcggaat gttttatgat c
//
