LOCUS       gnlProkkaAEOJNBKB_46   10615 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AEOJNBKB_46.
ACCESSION   gnlProkkaAEOJNBKB_46
VERSION     gnlProkkaAEOJNBKB_46
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 01:24:39
            Original ID  :: gnl|Prokka|AEOJNBKB_46
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10615
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10615
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1301:5615]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1302..5615
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10615
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10615
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             90..1238
                     /locus_tag="ctg46_1"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1302..2021
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_2"
                     /sec_met_domain="NTP_transf_3 (E-value: 4e-17, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2042..3343
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_3"
                     /sec_met_domain="CTP_transf_like (E-value: 2.1e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.1e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3360..4484
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4494..5615
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg46_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_5"
                     /sec_met_domain="Aminotran_5 (E-value: 1.7e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4584..5591
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg46_5_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg46_5_Aminotran_5.1"
                     /locus_tag="ctg46_5"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5612..6085
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_6"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             6082..7527
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_7"
                     /sec_met_domain="Polysacc_synt (E-value: 9e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             7527..8249
                     /locus_tag="ctg46_8"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             8263..9276
                     /locus_tag="ctg46_9"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             9281..10240
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_10"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-42,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 attttaggtt atgctacttc cttcagttct ttgggtatga tgattgcttc tattgctaat
       61 cttataaaga aataatagaa tttactttta tgtcagaaca acgacaggat aaaaacttgc
      121 tctctgaacc acacaagaca gaaagtgatg agatagaaat tgatttggtc gatatctttc
      181 gcaagattat tgctattcgt aaaaaattat acaaagccgt tggaattggt tttattattg
      241 gaataattgt agcggtaagt atccctaaac agtatacagt aaaggttacc ctttctcctg
      301 aaatgggtaa tgcgaagggg agtaatggtt tagccggact tgctgcctcg tttttaggag
      361 atggggctct aataggggaa agcacagatg ccttgaacgc ttctctttca gcagatattg
      421 tttcttcaac tcctttttta ttggaacttt tagaaatgga agtctccgtt tctaaaaagg
      481 atgataaaat gactttgggg tcttatctcg atgaagagtc atctccttgg tgggattatc
      541 ttataggttt tccgggcata gtaataggag gagttaaatc attattcgga gaagatacgg
      601 ttcctgccag tggagggcgg caaggaacta tcgaattgac gaaagaagta aatgagaaga
      661 ttaattttct taaaaagaag attagtgcat ccattgataa gaaaaccgcc ataacgagca
      721 ttacggtcac cttacaaaat ccgcagatca ctgcggttat agcagattct gtcgttcata
      781 aattacagga atatattatt gggtatcgaa cttcaaaagt aaaagaagac tgtgcgtatt
      841 tggaacggtt gtttaaagaa cgtcagcagg aatattatgc tgctcaaaga aaatatgcgg
      901 attatgtaga cgcccatgat aatgtggttc ttcaaagtgt acgtgctgag caggagcgtt
      961 tacagaacga catgagtttg gcttatcaga tatatagtca ggttgctaat cagttgcagg
     1021 tatccagagc caaagtacag gaggaaaagc cagtctttgc agtagttgag cctgccgttg
     1081 tacctttgaa accttcaggt atgggactca aaatttatat tttattattt gtgttcctgt
     1141 ccgtatctgg tactctcgtg tgggtgcttt ttggcaaaag tctgctggct agcttgagaa
     1201 aagaactgaa aaataaggag atagaacagg ataaatgatg ctaaaacgtc gtttacaaca
     1261 ttcttatatc aattaaattc acttactata ttattaaacg aatgatacgt acagctatga
     1321 taatggctgc gggcatggga acccgttttg gccaatatac agaattgata cctaaagggt
     1381 tcgtcaaagt gggaggtatt ccaatgatag ttcgttctat tgatactttg ttatcatgtg
     1441 gcattgagcg aattgtaatc ggtacaggat ataaacaaga agtttatgaa gaattgaaga
     1501 cagactatcc tatgcttgaa acctgtttta gtcctcgtta tgctgaaaca aatagtatgt
     1561 atactttata taatacgcgg gagattctgg gcaatgatga ttttttattg ttagagtcag
     1621 atttgatttt tgagaaacaa gcaataatga gcttattgga gtgtcctgcg gcagatgcaa
     1681 tgctaatagc tccagtgaca aagtttcaag atcagtatta tgtggaacat gatgataatt
     1741 ttcgcctttc ttcatgttct gtcaataaga ataaactaaa cgctaaaggc gaattggtcg
     1801 gcatccataa actatccggt tccttttaca aaataatgtg tgctgattat gcgagtattg
     1861 ttgatgaaca acccaatttg ggatatgagt atgaattact acgaatatct tgttctcaat
     1921 ctcctgttta tgtgcataaa gtagaagggc tgaaatggta tgaaatcgat gacatatcag
     1981 atttggaata tgcagagaaa tatattgttc cgtattgtta attaaaataa tatatcaaat
     2041 tatgagtaag acagtttata ttgggatgac tgcggatatt atgcatccag gacttatccg
     2101 cattattaat gaggctacta aatacggtga tgttataatt ggtcttctta cagataaagc
     2161 tattgcggag cataaacgcc ttccttatct gacctatgaa caacgaaaag aggtagttca
     2221 gaatattaaa ggcgtatgta aagttgttcc tcaagaagaa tggagctatg ttgagaatct
     2281 caaacgcatt aaacctgact atataattca tggtgacgac tggaaaaccg ggcctttacg
     2341 tgaagaacgt gtgcgcgtat ttgaagtgat gaatgaacag ggaggaaagg ttatcgaaat
     2401 tccatatact ttgggaatta attcatcttc tttggataaa gatattaagg ctataggtac
     2461 aacccccgat gtacgtttaa aatcacttcg tcgtttgata aatgccaaac ccgtagttcg
     2521 tattttggaa gctcatgatg gactatgtgg cttgataatt gaaaatcagg aaatattaaa
     2581 aggggataag agggaagtat ttgacggaat gtggtctagt agccttacgg attcaaccag
     2641 taaaggtaaa cctgatattg aggcggttga tttaactacc cgattgcaag atttgaataa
     2701 tattctggag tgtactacta aacctattat ttttgatgga gatacaggtg gtaaaattga
     2761 acatttcgta tttacagtac gcactttaga acgtcatgga atctcagcta taataattga
     2821 agataaagtt ggattaaaaa agaattcatt gtttggtacg gatgttattc aaactcaaga
     2881 tacaatcgaa ggtttctgta ataagatcaa agcaggaaag gcatctcaga ttactgatga
     2941 ttttatgatt atcgctcgta ttgagagcct tatagcggga aagccggtaa gtgatgcttt
     3001 agagagagct tttgcatatg tccaagcggg agcggacggt attatgatac atagcaaaaa
     3061 taagtcgggt gaagatataa aagaattttg tttggcgttt cgaaaacagt atgctcatgt
     3121 acctatcgtg gttgtgccta ctacatatga tcatatttat gagtctgaat tgtgtgattg
     3181 gggtgtgaat ataattattt atgctaatca tatgcttcgt gccgcttatc ctgctatgat
     3241 gaatgtcgca aagacaatat tagagaatga acgtgcttta gaggtgcgcg aactgtgtat
     3301 gcccataaag gaaatattgg aactgattcc gggtactaaa taaaaagagg aatatcatta
     3361 tgttaagcgt agaaaaagtt tatgaaacgt ttctgagtca tgacgttgat ttttttacag
     3421 gagttccaga ctcattacta aaaaatattt gtgcctatat cacagaccat acttcacgtg
     3481 agaaacatat catagctgct aatgaaggtg cggctgtagg aattgcttca ggttattata
     3541 tggcatcagg taaggttcct gtggtttata tgcaaaattc cggcttgggt aatactgtta
     3601 atcctctgct gtctcttgca gatgaacaag tatacagttt tccaatgctt ttgatgattg
     3661 gctggcgtgg tgaaccggga acaaaagatg aacctcagca taaaaaacag ggtgaggtaa
     3721 ctttagattt gttgaaagca atgcggattc cttatataat tcttgattca aatgagaatg
     3781 atgcatttat tcagctccat gatatcatac aatcagcaaa aactaagaat attcctcatg
     3841 caataattat tcggaaagat gtttttggca aatataaact tcaaaaagag ttcggatgta
     3901 attatccttt atctcgtgag gatgctttgc aaatagttgt ggattatctg cctgaaaatt
     3961 cagtggtcgt ttctactact ggcaagcttt ctcgtgagtt atttgaatat cgagaaatga
     4021 aagagcaagg tcatgaacat gattttctca cggtaggctc tatgggacat agttcatcaa
     4081 tctctttggg tattgctata gcaaagcaag atagacctgt ttattgcttg gatggtgatg
     4141 gagcatttat tatgcattta ggggcaatta gtaacattgg cgatttatct cctaaaaact
     4201 attatcatat tttgtttaac aatggtgctc acgagtctgt aggaggacag cctactttag
     4261 gatttagttt agatattccg gctattgtcc gggggagcgg atataagcat acttatactg
     4321 tttgtacaaa agttgaaatt gaagaagcaa tgaagcagct tccaaagtta tgtggtcctg
     4381 ttttgttgga aataaaggtt aaaatagatt ctcgggagaa tttgggacgt cccacgacta
     4441 ctcctataga gaataaggag cattttatgg attttttaaa ataaatatat tcgatgaaaa
     4501 tagaaagaaa aatattatta aatcctgggc ctgccactac tactgacagt gtaaaaatgg
     4561 cacaagttgt tccggatatt tgtcctcgcg agaaagaatt cgcaggtatg atgaaacaac
     4621 ttcgggacga tttggtcaga gttgctcatg ggaatttgga aaaacatacc gctgtattat
     4681 tttgtggctc aggaaccatc aatattgata tatgtctaaa ttctcttctt cctgaagaca
     4741 aaagggtgct tatagtgaat aatggggcat atagtacccg tgctgtagaa gtgtgtcaat
     4801 attatggttt gcctcatatt aatttggaat tttccgttta cgaacgtcct gatttatcgg
     4861 tggtggaaaa tgtgttgcaa gaaaatcctg atatagctat ggtttatact actcatcacg
     4921 agacgggtac aggaattctg aaccctattc gcgagatggg cgctatagct cataaatatc
     4981 aggctaaatt tgtcgtcgat actacttctt ctttgggcat gattcctttt gatatagaga
     5041 aagataatgt ggatttttgt atggcatctg ctcaaaaagg acttcaagcg atgacaggtc
     5101 tttcttttat tataggcaat gaggaacaga ttaagttttc aaaaaaatat cccaagcgtt
     5161 cttactattg taatctttat ttgcagtatg agaattttga gagaacaggt gaaatgcatt
     5221 ttactccacc ggtacaaact atttacgcca ctcgtcaggc attaaatgaa tattttgaag
     5281 tgggcgaaga agctaagttt gcccgtcaca aaagagtttt tgaggctatt cattcaggta
     5341 taaatgaaat tggtcttaaa agtgtaataa agcgtgaatg gcagtcagga ctggttgtct
     5401 cagttcaata cccagaagat cccaactggg attttgagaa aatacatgat tattgttatg
     5461 agcgtggatt tacgatttat ccaggtaaga tatcaactga ggatactttt agaatctgtg
     5521 ctttaggaga gatagaagta gatgatattg agaacttctt taaagtacta aaagctgcat
     5581 taaatcatta taacgtcaca ttaccgatgt catgattgca gaaatattat tgaagattcg
     5641 tcatttttat ttttcccttc gtggtataca cttccatccg gaaagtgtta tttctggagt
     5701 gcctattcgt agctttcgct tagtaggcaa atatagcaat atctacttag gtaaaaatgc
     5761 tgaaatacgt tcaggctgtt atctgattgc tcgtgataaa atcattattg gagaaaactc
     5821 aacactcgcc tatggaacga ctatattgac aactgctgat cctaatggac cgtataatgc
     5881 attagcagtt ctttatcctt ataaaaaggc accggtagtt ataggagata atgtttggat
     5941 tggggctaat gttaccatcc ttcctggagt aactattggt gattacgttg tagtagcagc
     6001 tggagctgtt gtaacaaaag atgtaccttc aggagtattg gtagctggtg taccagctat
     6061 tgtgaaaaaa cgttttaata aatgaaagaa aaaacttctt taaagaacaa agccatatgt
     6121 ggaatctttt ggagtgcagt tgaacgattt ttatcacagg ggatacagtt tgtagttaca
     6181 gtcattatgg cgcgttttct attgccatct gattatggaa tggtaggaat gttagcaata
     6241 gttcttcaat tatctcaaac gttaatggat agtggtttta ctaatgccct tattcgttat
     6301 aaggaacgta ctgaaattga ttattcaaca gttttctttt ttaatatatt agcatcatta
     6361 gttatttatt ttctaatttt ttttctagct ccttatatat cgtggtttta taaaataggt
     6421 caattagttg agattactag aattttatct attgttattg ttttaaattc ctttgcgatt
     6481 attcctaaaa ctaaattaat aatagctgta gattttaaaa ctcaatcaaa agtctcattt
     6541 attgcagctt tggtttcagg tattattggc atttgggctg catatttaga ttttggagtt
     6601 tgggctttag ttggacaaac tttagtaaac ggattgttga ttgtagtttt gtatgcatat
     6661 ttttgtagat ggaaaccatt gtggatattt tcattgaaat cgtttcgttt attatttgct
     6721 tttgggtcaa aattagtatt agctaatatt cttaatactt tatataaaaa tctgtatgct
     6781 atagttatag gaaagaagtt ttcgtcggtt gatttaggat tttatactcg tgcggaacaa
     6841 tttgctcagt ttccttcata taatttgagt gcaataattt ctagagtgac ataccccata
     6901 ttgagccttg tgcaaaatga taatgataga ttatctgctt tatataggaa atatgtccgt
     6961 ttatcttctg cttttatctt tccattgatg attttgttaa ttgtcatagc tcagccactg
     7021 gtattattgc ttttgacaga aaaatggata ggagtagttg tattgcttca aatattgtgt
     7081 ttagattgga tgtttgatca tttgagtagt ataaatttga atttactata tgtaaaggga
     7141 cgttcagact tggctttacg tttagaagtt ataaaaaaag tgttagcgac ggggatcctt
     7201 cttctatcta ttccttgggg gattgtaggt atgtgttggg ggcgtgttat gtattcattg
     7261 attgctgtgt atttgaatac ttattataca gaatcattga ttaaattaag tcttattaga
     7321 cagatgagag atatactacc aagctttttt ttagcattaa taatgggagg aggtacttgg
     7381 tatatgattt tattgttaga gggtgaaatt gttcaaattg tagtaggaag tgttattgct
     7441 ttattgctat atggaacgtt gttgtattgc ttttctcgat ccttgtttga tgaaatatgg
     7501 gcggttatat taaaaataaa aaggtaatgg ataaactgag tttgattatt agtaaaatac
     7561 gacggaatca ttggtataga acctatatgc gtcctatata tttatttgtt tatggcaata
     7621 gaaaattgaa gaatagaaat agaatatttt tgcagtattc acaagagctg ctaactaact
     7681 ttcatcaagc aatgaatgaa gtgggaattc cttattggtt agaatttgga actcttttag
     7741 gtgctgttag agaacacagt tttataagtc atgattttga tcttgatgtg ggccttttta
     7801 aggaagatta ttcagatata ataagagagg tcttaaaaaa atatggtttc aaaagaataa
     7861 ggtgtataac cgcccttgat tttattgatg cttatgagga aacttatctt tataaaggtg
     7921 tgacaattga tcttttcctt ttttcaagag agaaaaattg tgatggggtc tattgttatg
     7981 attttgttcc agtatattca gatataaaga gaactaaaaa aggtgataat gcaatccgga
     8041 gaattcattt tcctagaatt gatttgattg aatattcatt tattggaatt aatacttttg
     8101 ttcctgaaaa ttatgaggaa catctttgta tgcattatgg taaagactat atgattccaa
     8161 atcctcattg gaaagattca gatgcgcaac atactgatat cttttatggt agagagatta
     8221 gaattgaatt gtttgataaa agtaaataat agtagataat acatgttcta tctatttttt
     8281 ttactaattg tgctattttt gttatatata caaagtagga aaagacaata ttctactgta
     8341 gcgggaattt gtgttcctat tattataatt tttgttgtaa tttgtcgtta tagagtgggg
     8401 tatgactatt taacgtatta tacattaatt gaaaatgaag aagaggcaca gattttatac
     8461 ttattttctc ctttaagcat tgtttgggca gagattgctt tatattttga atctccacag
     8521 atgttatttg ttctttttgg gcttccaaca tttgctcttc taatatttac tttaaaaaaa
     8581 tattcaaaag attatgcgtt atcagtaact attttaattt gtttcttctt ttttacatca
     8641 ctcagtatta ttcgacaagc tttggctttg gctatttgtt tttatggtta tcgttttata
     8701 gtaaaacgtt cactaattaa atatatatta tgtatattga ttgcagcttt attccatcct
     8761 tctgcaggag tagcgattat tatatattgg ttgccatttc taaagtttag attagttgta
     8821 ttattatcta taatatcaat agtagccaaa cctttatttt tttatatgct aaatatatta
     8881 ggggtgtata cctcttatct tgatggcaag atggatattg aaggtgggaa atatactcaa
     8941 ttaatatact ttttgttgtt tattatttgt tttgttttgg gaagtaaaaa catagataaa
     9001 aacaagtgta atttatttaa tgttttattg ttaagttttg ttttcgtatc ttttttagga
     9061 gctcatttag gcgggagaat agcgttttat tttaatatat attattgttt gttgattcct
     9121 aaagtggtta aaggattgga tgggcaacta agagagcaag tgaagcttct ttcttatttt
     9181 ctatgtattt cttatttctt attgtaccta ttcgttccat tcataaaagg tgtaccctca
     9241 tattatatcc catataagtt tatatttttc aaatagtaaa atgttgatat ctataattgt
     9301 cccttgttat aattctgaaa gatatttgtc tgattgttta ttgtctatat tgaatcaaac
     9361 ctatgttaat tgggaggtga tttgtataga tgatggaagt caagataata cattatctat
     9421 tttaaatcat tacgctacat tggatgagcg ttttaaaatt atttctcagt ctaatgcagg
     9481 agtgtctgtc gcaagaaata aggctctatc ccagtgtcaa ggagagtata tttgctttgt
     9541 tgatagtgat gacctgatag aacctaattt tttgataaca cttttacagc ttataagtca
     9601 tcaggctgat ttggcaatct gtggttttac tcgttctatg gttttctgta tggatgatgc
     9661 tcaaggatat atagaaatga gtggtaaacg ttgtatagaa agaattattc tagataaaag
     9721 tttcaatcct cagatttgtt gtatgttatt tcgacataat attataaaag agaaacaatt
     9781 agaatttgtg atagggtgta ctcgtggtga agatcgtgaa tttatattga aatatttagt
     9841 ttattctaat aaggtttgtt atacaaacaa tcttctttat cactatcgtg taaatgatca
     9901 gtcagccatg gcaatctttt ctattaaaag tttgacaagt atagaagctt cacaacgcac
     9961 ggtcaactac tataaaaaag tgaattattc tgttagaggg cttgaatttg aattttcacg
    10021 tacattgtgg aaattcatga ttttagctat tttgtctggg caaaatgatt tatatcaaat
    10081 cattcgagaa aagtatgatc taaaaagaca aatggaacat ctttattctc atccaggact
    10141 atccgaaaaa cttacagcga gattgtttgt ttggaatgag gcacttttta aatgggtatt
    10201 ttctattatt agatatctat ataaaaaaag atggagatga ataaacgaaa tagattatct
    10261 gaacaagaaa taaaaaaagt agaacttgac gctttattgt atattcggaa aatttgtcag
    10321 caatatcatc ttcgctatta tttagcttgg ggtactttgt tgggagccgt taggcataaa
    10381 ggatttattc cttgggatga tgatattgat ataatgatgc cacgttcaga ttatgagcga
    10441 ttattggagt tagttccttc cttgagacat agttattata aaatcttaag taatccaaag
    10501 aatgaggatt attattatac tcatgcaaaa atgatagata ctcgtacttt gtgtgtggaa
    10561 aatgatttgc aaactattca aaatatgggg atttgggttg atattttccc cttag
//
