LOCUS       c00015_gnlPro..        16656 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NCELMIHK_15.
ACCESSION   c00015_gnlPro..
VERSION     c00015_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 03:18:14
            Original ID  :: gnl|Prokka|NCELMIHK_15
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 34023
            Orig. end    :: 50679
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16656
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[44023:49136]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15113
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16656
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16656
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             864..2390
                     /locus_tag="ctg15_25"
                     /transl_table=11
                     /translation="MAKETRIMGKRAAGILMPISSLPSDYGIGCFSKSAYEFVDWLKEA
                     GQTYWQILPLGPTSYGDSPYQSFSTFAGNPYFIDLDTLVEEGVLDKKDCEKVNWGKKPD
                     EVDYEKIYKGRYPLLRKAYENSDISKNPDYQKFVAENSWWLSDYALFMAVKDRFEGVEW
                     TKWAEDIRLRWNNAMDYYREELYFDIEFQQYMQFKFYEQWMKLKSYANSKGIQIIGDIP
                     IYVAMDSADAWAHPELFQLDQDNVPLAVAGCPPDGFSATGQLWGNPLYRWDYHRNTGYQ
                     WWISRMSYCFRLYDVVRIDHFRGFDEYFSIPYGDKDARGGHWEKGPGIDLFRKIEQALG
                     WKQVIAEDLGYMTDSVRHLVYESGFPGMKVLEFAFDSRDSGCASDYLPHNYPENCVAYT
                     GTHDNETIVGWWKSITAAERKLARDYLCDHATPEEELYKCFISLIMRSAARVCVIPMQD
                     YMGLDNRFRMNKPSTVGTNWKWRIKKRDLTKKLQKEIYDVTLRYGRKNWD"
     CDS             2720..3250
                     /locus_tag="ctg15_26"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGNET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
     CDS             3503..4921
                     /locus_tag="ctg15_27"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVQPGGHILVDDGLVDLEVQDIAGKDIVCKVINAGVIGDRKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILAVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             4921..5121
                     /locus_tag="ctg15_28"
                     /transl_table=11
                     /translation="VEQVMKRLVIKNKRKIWLWFLFIVLLILACRAAYVTGNKNMQIRD
                     EAVEEQQVENVMGQDKVERLC"
     CDS             5115..5879
                     /locus_tag="ctg15_29"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMDKLENARVAVFGIGGVGGYVCEALVRSG
                     VGAFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGAAHKCTER
                     RDIPGSVAFVPSVAGLIIAGEVIKDLTAEYRR"
     CDS             6193..7377
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.3; E-value: 1.8e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg15_30"
                     /sec_met_domain="MFS_1 (E-value: 1.1e-24, bitscore: 78.3,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGILFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(7790..8755)
                     /locus_tag="ctg15_31"
                     /transl_table=11
                     /translation="MSLLKEISITELSNLRIGHTSDHDAKTGVTVLYFPNGAKAGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGNPKIRPTAKMGEEACRRAFAGTDTRTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVKNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSQIQDEEFLKYV"
     CDS             complement(9014..9652)
                     /locus_tag="ctg15_32"
                     /transl_table=11
                     /translation="MNTTTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTP
                     GLSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFI
                     VCIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYI
                     QGIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             complement(10001..10297)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_33"
                     /sec_met_domain="ALS_ss_C (E-value: 6.7e-22, bitscore:
                     68.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEVIKVIDFTDVFVRMKEILYIKVFNCSREDKAELFQIAETFQA
                     KVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVHGGNVGIESISMMER"
     CDS             complement(10562..11275)
                     /locus_tag="ctg15_34"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             12038..13294
                     /locus_tag="ctg15_35"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKGKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKMEEP"
     CDS             complement(13363..13872)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_36"
                     /sec_met_domain="ALS_ss_C (E-value: 1.6e-22, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(13890..15113)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_37"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.8e-49, bitscore:
                     156.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFL
                     AGGGVVISRAHEIFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVS
                     NCDVLFSIGTRFNDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITK
                     MNEYVQECSTDKWLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQH
                     QMLVSQYAEITEGKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQE
                     LATAVLEELPVILCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYT
                     PDFIRLAESYRAKGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGT
                     LEDMIMDC"
     CDS             16582..16656
                     /locus_tag="ctg15_38"
                     /transl_table=11
                     /translation="LSKYYSIHEFSKIIGVSAQTLRNWD"
ORIGIN
        1 gctgatgtta ggataaactt cgctgtaaga accttccaga taggtgttgg cgatcatgaa
       61 gtttccgcca tgtccaggac cggaaagcag gatcatatca aggtcataac gtttgatgac
      121 acggttgcag tgtgcataaa cgaagttctg tcccggtaca gttccccagt gaccaacaat
      181 ttttttcttg atctgatcca tagttaatgg ctctctcaga agcggattgt cgagaagata
      241 gagctgtccg gcagacagat agttagctgc acgccagtaa gcatcgattt tgtcaagcat
      301 ttcctggttt aaaggctgct tttccagaca taatttgttg tcttccattt tcttacctct
      361 ttctttgtct ttgatgtgta tagcttaaga tgtcgaagat atctgtataa gaaattttct
      421 gatggtagtt aatgataaac gtttctcaac agataagttg gagtgttact ttgttatttt
      481 ttaaccgaac acatcctatc atatcagaaa tgaaacgtaa aatagaaata ttgcattgta
      541 attataagtt tttgatatgg ataaaaaata agctccttct gatgaaatgc ggagcagtta
      601 ttcggtatag agctgcgtag cgaagcagat tgtgaatatc cgcttgacga caattctctg
      661 agtggaaatg agtggtgttt aatatggaag atgacgaaaa gaactaagca atgattagta
      721 attttcacga aaaaatggat aacatgaaag ttgtattgca atttgcacaa aaaatagata
      781 taataaaaaa aacaattgcg cataaggtat agaaaaactg cttatatgta cactagataa
      841 agtataggcg gtaaaagtga agaatggcga aggagacaag aatcatggga aaaagagcag
      901 caggaatatt aatgccgatc agcagtcttc catcagacta tggtatcgga tgtttttcca
      961 aaagtgcata tgaatttgta gactggttaa aggaagccgg acagacttac tggcagattc
     1021 tgccattggg accgaccagc tatggagatt ctccatatca gtctttctct acatttgcag
     1081 gtaatccata ttttattgat ctggatacac ttgtggaaga aggagttctt gataagaaag
     1141 actgcgagaa agttaactgg ggaaagaagc ctgatgaggt agattatgaa aaaatctaca
     1201 aaggccgtta tcctcttctg agaaaagcat acgagaacag tgatatcagc aagaatcctg
     1261 actatcagaa attcgtagca gagaacagct ggtggctgtc agattatgct ctgtttatgg
     1321 cagtaaaaga ccgtttcgaa ggtgtagaat ggaccaaatg ggctgaggat atcagactcc
     1381 gctggaacaa tgccatggat tattatcgtg aagaactcta ttttgatatt gaattccagc
     1441 agtatatgca gtttaagttt tatgagcagt ggatgaaact gaaatcctat gcaaattcaa
     1501 aaggaatcca gatcattgga gatattccga tttatgttgc aatggacagt gctgatgcat
     1561 gggcgcatcc ggagctgttc cagctggatc aggataatgt accgctggca gtagcaggat
     1621 gccctccgga tggattttct gcaaccggtc agttatgggg aaatccgctg tatcgctggg
     1681 attatcacag aaatacagga tatcagtggt ggatttccag aatgagttac tgcttcagac
     1741 tgtatgatgt tgtgcgaatc gatcatttcc gtggatttga tgaatatttc tctattccat
     1801 acggagataa agatgcaaga ggcggacact gggaaaaagg tcccggaatt gatctgttcc
     1861 gtaagatcga acaggcgctt ggatggaagc aggttatcgc agaggactta ggatatatga
     1921 cagattctgt acgtcatctg gtatatgaga gcggcttccc gggaatgaag gttctggaat
     1981 ttgcgtttga ctccagagat tctggatgtg ccagtgatta tctgccacat aattatccgg
     2041 agaactgcgt ggcatataca ggaacccatg ataatgaaac tatcgtggga tggtggaaga
     2101 gcatcacagc agctgagaga aaactggcga gagattatct gtgtgatcat gcaacaccgg
     2161 aagaagaact gtataaatgt ttcattagtc tgatcatgcg cagtgctgcg cgtgtctgcg
     2221 ttatcccaat gcaggactat atgggactgg acaacagatt ccgaatgaat aaaccatcta
     2281 cagttggtac gaattggaag tggagaatca agaagagaga tcttacaaag aaactccaga
     2341 aggaaatata tgatgtgaca cttcgttacg gacgtaagaa ctgggattaa atacataatg
     2401 aaataattgg aataatgaca gcgtttcgga tataaataat atttggaacg ctgttttttt
     2461 aaccgaatca agcagttatt tggtaaaaaa agcaacgaag tggttggttt tatctgtttt
     2521 gttttatcca gtcagagtca tctgtcagag ggaaaaaaag gacagtttcg caaggtcttt
     2581 atttttgtat gaaaaagaaa acattgaaat tgttttgacg ggcgtacaat tgaaaaagaa
     2641 atgcattgat tttcgggcaa tgtctgataa aatattaacc agaaaaaaca aaagaacaga
     2701 ttttcaggag ggaaaataaa tgaactataa cagattagaa accagtctga tcgatgtgat
     2761 caaagaggaa caggcgaagc ttggatatat gaaggagaag atcagccttt attatccgct
     2821 cagttccctg aatcatttct ttggcaatga gacggatgct gcaggcatga tggagatttt
     2881 aaaagatttt ccttcttata tagaagagaa atttggtgaa gtagcagtat cacacagagg
     2941 agatcgtttc tgcttcactg tttcggaaaa agcttccgaa tatgtacata ataatatgaa
     3001 agagaatgaa tttatcaagg cattgatcga actggttggc agacatggat gtacgataga
     3061 ggaaattaaa gaactgttcc attcttattc agataaaatc attactgaac caatggataa
     3121 cgaggagttt gatgtgatga tccgctttga tgacggatca gatccttatt attattgttt
     3181 taaagatgaa ggatgccata tcatttacca cagatttctg ccggaagact atgcagattt
     3241 tggattctga taagaatgag tgaaaatttt ccaactgtcg gatcagtaaa aatatatgtg
     3301 atatttgcaa caaaagtatg ttattttttt gtcaaatatc aacaaaaata agtcgaaatt
     3361 ctatattgac agatagtctc aataatggta atttttattt gatttaatgt tttcatttat
     3421 agaaacaggt aacattttat tacattattt tacaggaata aaatagataa aattgagttg
     3481 acagtttgga gggaaagatt aaatgagaaa aaccaaaatt atctgtacaa tgggaccgtc
     3541 tactgataag ggcgatgtta tggagcagct tgtgagagag ggaatggacg tagcacgttt
     3601 caacttctca catggacctc acgatgagca gagaggccgt atccagaaac tgagagaact
     3661 tcgcaagaaa tatgacagac ctgttgcagc acttcttgat acaaagggac cggagatcag
     3721 acttggatgc ttcaaggatg gcaaggtttc tctggaagaa ggacagatat ttacatttac
     3781 aaataaagat attgaaggaa ctaatgagtg cgtaagcatt acttataaag agctttataa
     3841 ggatgtgcag ccgggcggac atattctggt tgatgatgga cttgtagacc tggaggttca
     3901 ggacatcgca ggaaaggaca ttgtctgcaa ggttattaat gcaggtgtga ttggcgacag
     3961 gaagggtgtc aatgttccgg gtgcaaacct gaagatgcca ttcatcagta aaaaagacca
     4021 tgatgatctt ctcttcggta tccaggaagg atttgatttc gttgcagcat cttttacacg
     4081 tactgcaaac gatatccgcg aagtaagaaa aatcctgaaa gaaaacggtg gtgaagagat
     4141 tcagatcatt gcaaagattg agaaccagca gggcgttgac aatatcgacg agattattga
     4201 agcagcagat ggcatcatga tcgccagagg tgacatgggt gttgagatcc cgccggaata
     4261 tgtacctgtt atccagcaga aaatcatcca gaaagtttac acagcaggaa aaccggttat
     4321 tacagcaaca cagatgcttg actccatgat ctctcatccg agaccaaccc gtgcagaggc
     4381 tacagacgtt gccaatgcga ttttccaggg aacaagtgca actatgcttt caggagaaac
     4441 cgcagctggt aaatatccgg tacaggcact tcagatgatg agccgtattg cagaacatat
     4501 ggagcagaat attgattaca atacaatctt taagaaaaca gacagaaatg agaatccgga
     4561 tatcacaaat gcaatcgcac atgcaacctg tctgaccgca atcgacttga aggccagtgc
     4621 aatccttgca gtgacaaaat ccggaagtac agctcatatg atgtccaaac acagaccagg
     4681 atgtctgatc ggtgcatgta caagctctga gagagttctt cgccagctga atctatcctg
     4741 gggtgtttac ccgatgctga tcaaagaaga atacagttct gagatccttt gcctgagagc
     4801 aatcgaggca gcacagaagc ataaacttgt aaaagttggt gacactattg tatttgccgg
     4861 tggtgtaccg cttggaattc cgggaagaac aaacctgatc cgcgtctgca cagtagaata
     4921 gtggagcagg ttatgaaacg gttagtcata aaaaataaaa gaaaaatctg gctctggttt
     4981 ctgtttatcg tgcttctgat cctggcatgc agggctgcat atgtcacggg aaataagaat
     5041 atgcagataa gagacgaggc agtagaggaa cagcaggtag agaatgtaat gggacaggat
     5101 aaagtggaga gattatgctg aatcaatttt cgagaactga gcttcttctt ggaaaagaag
     5161 cgatggataa actggagaat gcccgtgtgg cagtatttgg aatcggagga gttggaggtt
     5221 atgtatgtga agcattggtc agaagcggcg taggggcctt tgatctgatc gatgatgaca
     5281 aagtatgcct gacgaatctt aacagacaga ttattgccac caggaaaact gttggtcaat
     5341 ataaaacaga ggtgatgcgg gacaggatcc tggacattaa tccgaaagca gatgtgagaa
     5401 tccataactg tttttatctt ccggagaatg ctgctgactt cgattttagt gagtatgatt
     5461 atgtggtaga tgctgtggac acagtgactg cgaagattga actgatcatg cgtgcaaaag
     5521 aggcagggac tcctgttatc agcagtatgg gtgccggaaa taagctggat gccagtgcat
     5581 ttcgggtggc agatatctat aagacgaagg tgtgcccgct ggcgaaggtt atgcgcagag
     5641 agctgaagaa gcgtggtgtg aaaaaactga aggttgttta ttcggaagaa cagccgatca
     5701 gaccgattga agatatggca atcagctgca gatcgcattg tatttgtcct ccgggtgctg
     5761 cgcataagtg tacggagcgc agagatattc cgggcagtgt ggcgtttgtg ccgtctgtcg
     5821 ccgggctgat tattgcagga gaggttatta aagacctgac tgcagagtac agaagataag
     5881 aagtgtttat tttgagatgt gtatggtgtc agaaatggta tggtgcacat ctttttttgc
     5941 gggaaatatt tggaatcgaa tgggggtatt actttttgga ttttatagaa ttgttatagg
     6001 gaaaaagtca aaataatata aaaatttatg ggattttcaa aagataatga aagaaaaagg
     6061 agagaatctg tgatacactg tcattattga cggatagaaa tctattagaa ctgtggagat
     6121 atagaagttt ggtaggtcaa tgtctgaatg atgtcagctt aataaatttc agattggagg
     6181 atataacatc ggatgaaaac aaattacaac agaacagtgc aggcctgttt tatcggatat
     6241 gtagtgcagg ccattgtgaa caatttcgtt cctctgctgt ttctgacatt tcagggcagt
     6301 tacgggattt cgctgcagaa gatcacactt ctggttacat ttaatttcgg gatccagttg
     6361 ctggtagatc tggcatcgat tggatttgtg gacagaatag gttatcgtgc atctatgatc
     6421 ctggcacatg caatggcggc tgcaggtctg attttgctca cagtattgcc ggagtgcctg
     6481 ggagatccgt ttgtgggact tctcattgca gttatgatct atgccatcgg aggcggattg
     6541 ctagaggtgc tggtaagtcc tgtggtggaa gcctgcccta cagataataa ggaaaaagca
     6601 atgagtctcc ttcattcctt ttactgctgg ggacatgtgg gagtggtact tctttctaca
     6661 ttattctttc gtattttcgg gattgcaaac tggaaatata tggcgctggt gtgggctttg
     6721 attcccattg caaatggaat cctttttacc agagttccca ttgctccgct gctggatgag
     6781 ggtgaaaagg ggctgactat gggagagctt tttaagaaaa aaatcttctg ggttctgatg
     6841 ttaatgatgc tctgtgcagg agccagtgag caggcggtaa gccagtgggc ttctactctg
     6901 gctgagaaaa gctttggaat caataaaact atcggagatc tggcaggtcc catggcgttt
     6961 gcaattctta tgggaagctc aagggcattt tatgggaaat ttggagataa aatcaatctg
     7021 gaacgcttta tgcaatacag tgcagttctg tgcatggttt cctatctgat gatcgcattt
     7081 atcccggtac ctgcgttggg aatccttgga tgtgcggttt gcggtctgtc tgtaggtatt
     7141 atgtggccag gaaccttcag catggcggct gcctcagtaa agcgtggcgg aacagccctg
     7201 tttgccctcc ttgcccttgc tggagatgtg ggatgctcat ccggaccaac ctatgtgggg
     7261 atgatttcag gagcactgaa tgataatctg aaacttggaa tctttgcggc attgattttc
     7321 cctgtgttga tgataatggg gattaagatg attggaagtc tgcaaaaata tgattgagat
     7381 atattaaaaa gtatggaacg attaattttt catattgatg taaacagcgc atttctttcc
     7441 tgggagtcag ccagaagggt aagccagggg ctgccggatc tcagggatat tccctcctgt
     7501 gtgggaggaa atccaaagaa acggacagag tacacacgct gttcccggac gaaataccgg
     7561 agaaaatgtg gccacttcct gtccgtaaca tgttatttct gggaaaagcc tccgagcaga
     7621 agcttctgaa tcagggaatc cgtactattg gtgatctggc aagggaacgg gaagcaaatg
     7681 tacagctctg gcttggagaa aaaccagagc acagatgaaa aatgaagaca gacaggaaga
     7741 ataaaagcgc agagatgata ctttttctct gcgcttttat agcggactgt tatacatatt
     7801 tcagaaattc ttcatcctgg atctgggaag tatggatggc attttggata gcctgagcca
     7861 tgacttctgc ggcgagagtt cctgccatat tgatatctac agaaacatcg ccaatgctgg
     7921 cagcatagat ggaatcgccg tcagccatag ttgctacagg attgatgcat ctggcatagg
     7981 cacagcgggt catagaggca attttattca gttcagcctt tgaaaatgcc ccattggtga
     8041 tcacagctcc gatggtggta ttgccggtaa actggtcatg aggtgtcata aagcggtata
     8101 attcgtggac actgtccaga aacccgcttc tgtcaggcgt tttcagccct gcaattttct
     8161 gaccattttg tggactaaag atatctccca gtgcattgac aacgacaatt gcagccatct
     8221 ggaaattttt cacagataca gcggcaatac caagacctga cttcatggac tgtttcatac
     8281 cgtaaagttt tcccacagtt gcaccggtac ctgcaccgat atttccggtt ctggtatctg
     8341 ttcctgcaaa tgcccgacgg caggcttctt cgcccatttt tgcagttgga cgtattttag
     8401 gatttccgta agagaggtca tagatacagg actggcatac aagaggaacc agggctgcac
     8461 cggtgttata accgatattt tgtgattcaa gatagttcat tacaccgtca gcagcagcca
     8521 gtccataggc agaacctccg gacaagacaa tagcattgat gggattgtcg gcagtgacag
     8581 gagaggtgag aggagtttct ctggaagcag ggccgcctcc gcttatatcg cagcctgctt
     8641 ttgctccatt tggaaaataa agaacagtta caccggtctt cgcatcatgg tcagaagtat
     8701 gaccgatgcg taaatttgaa agctctgtaa tagaaatctc ttttaataat gacataaaaa
     8761 tctcctttat tatgtgatag caattctatg aaatactgag agcaatccag cctatcagaa
     8821 tgtgaagtac tgcgtcagat attttccttg tctttcgcac tctgctgaac tgtcttgatt
     8881 gcattatttt gtgagattgc tatagatatt aattgaatca ggtaggattc ctgttttaaa
     8941 tgtgccagat aaaaaaacct gactacggtg acaatgtagt caggtttttt ggaaaaggct
     9001 gttcttttaa agattatgca cgtttcagtg ccacagaaag tgccttggaa acgatacttc
     9061 ccactacaaa gcagaagccc gcttcgatca gtccctgaac gcccacaaaa gcagcaacga
     9121 agacaacagg attgcttact ccaagactgg aaacaatacc ctgaatgtaa tctgtgttgt
     9181 agaagaagag acataaaaag cccatgaaga agaaagtatt cagtaacggg catgccagtg
     9241 aagcaacgta ataggaaaat ttcttcgccg gtgatttata taatgctgcg aaaataagtc
     9301 ctgtgatcca tccttccagc acacgtgcca cgatacatac aataaaagtg ccaaatggat
     9361 taatgttaaa aagtgcggca gcgaaagctg aacttcctgt gacagccata tagaagctgg
     9421 ttgcaccgaa agcaagtccg catacagcac cacctttcgg tccgaggatg atagctccta
     9481 cagctaccgg gatggtgaga agagtgatgg ataagccggg agtacgaagg tagcccagcg
     9541 gggtaaagga catgagcaga ataatggcga tcatcatagc caactctacc atgtaaagag
     9601 tgctgcttct ttttgctgca gccgttgttg tagtggttgt tgttgtgttc atatgaattc
     9661 tccttttggt ctgataaaac ggcgcaatgc gtcccctgct tttcagacag tttagagtat
     9721 ggggatcagg cgttatgaaa aatatgcatc agaacaaaag aaaaatttcc ggtgtgtaga
     9781 cgccttacag gtcgcctcac gaatttaacc agactgtgaa gtggatgact ttatccacca
     9841 gactgtcaga tgtggaaaac agatgcattt tctttcgaat aacgctcccg taaaccataa
     9901 cacatttgat taaaaactgc aatattttat agtatgtttg aaaataaata caggatatag
     9961 aggtgtttct atatcctgta aaaaatattg attatgagat ttagcgttcc atcatgctga
    10021 tggattcaat tcctacgttt ccaccatgta ccacttcaat tctgtggaat tcttccttga
    10081 tcagtttgac aactgcatca ttcttggtgg ctgtctggac aaattccaga agcaggctgt
    10141 ctttgccgta gtcaatgact tttgcctgga aggtttctgc aatctgaaac agttctgctt
    10201 tatcttccct ggagcagttg aaaaccttga tgtagagaat ttctttcatt ctgacaaata
    10261 catctgtgaa gtcgattacc ttgataacct cgatcatgcg gtttaactat tttttgatct
    10321 gttcaaaggt ttcatcatcg ctgactgttg cgatagtcat tcgggatact gtaggatcct
    10381 cggtggttcc tacagtaaga ctgatctatc acgagatatg taaatggtta agtgagtttt
    10441 gttaattaaa atgtactaaa atgtcgtctt ttttgacaag aaattataga aaataaacaa
    10501 aataacacaa tgcaaaaaac aatgcataaa ataaaagaat gtccctttga ggaacattct
    10561 tttaacgtgt ctgaaggaaa acttttaatt tgggaagctg gttgttaagg ataagagttt
    10621 ccggaaacat gagctggtga acgaattctt cggcataggt gaaatctcca acatgttctt
    10681 ttccgtggct gtcgctggac aaaataacag gaagctgata tttctgacag agatacagga
    10741 ttctggctgc attggctctt gtgtctcccc gatatcctcc gggtgcgagg gaagcttcgt
    10801 ttatttcaaa aataacattt tcccgtaaag ctgctcttgc cagcgtttca taatctacag
    10861 ggaaatgtgt atcgtcgcag tggccgagta tttttacagc aggatgtttt attgcattga
    10921 tgtaagcttc tgtattctga gatacagagc ctgaacggta gttctgccga tgcatactga
    10981 tgatagcgta atccaggttg ttcagcagtt catctgacag atctgtatgt cctgcactgt
    11041 ccaggatgtt tagttcaact ccgtaaagaa tatctatgcc gaatcttttt ctgggataaa
    11101 aaggaaggct tctgaaataa gaagaagttc cggaagccag agttcccggg ccgtggtcag
    11161 aaatcccaag gagtttcagt ccttttttgc tggctgcttt tgccatgtca gagatggtac
    11221 aggtggttcc gtgaccgctg gcgatagaat gtgtgtggat gtcagaaaga tacattgttt
    11281 gtctcctttc cagagcggtt tctatatatg ataagagcct tacggaagat gcaaagctgc
    11341 tgtttgatgg tacattcgtt atattcaagt atgacagatg aggatttaaa tgtcaatgag
    11401 gaaacaaaat aaaaacaact gaaatacaac aaaaatcaaa taaaaagcaa cacaaataaa
    11461 cggctgatac atgttaaatt atgttgactt cgggaaaatg agaaggtata atggaactat
    11521 atgaaaacat gggggcttat tgctgatcaa tgacagcgat ggcactgttt gcttatgtgt
    11581 agacagttac ttcatgagaa aggagtaaca tggaaaaatt tcaaacatca gacattcccg
    11641 gaattctctt atgaatggct ggaggctgaa ctggatactg gtatgattcc acaaatatgg
    11701 acagcgaaga aattgctcct aacctttatg actaatcgat aagtatatat cgagaggaaa
    11761 tgaatcctca gaattaagta aaaaaagtta ccgggaacaa tgtgaccggt agcgaaatac
    11821 agacgccgca ctgccgtatg gcaagtgcgg cgttgttgtt caaaactctg atagcagagt
    11881 gaaatcaaac aaatataaat acagtaacag ctcagacaag atgatgtaaa taaagacact
    11941 tttttggaca aacgaggttc ttaccctgga gagcagatca gggtaaaatg aaatcatcag
    12001 atatgaagag cgcaattcat atattggagg aagaacagtg aaaagtacgg aacggttaat
    12061 ttttcatatt gatgtcaaca gtgcatttct ttcctgggaa tcagccagaa gggtgagcca
    12121 ggggctaccg gatctcagag aaattccttc ctgtgtagga ggagatccaa agaaacggac
    12181 aggtatcgtg gttgccaaat ctatccctgc aaaaaaatac gggatccaga ccggcgagcc
    12241 agtagccatg gctcttcgga aatgtcccaa tctggtgatc gttcccagtg attttgaatt
    12301 atacgataaa tgttcccggg catttaaagc aatctgtgct tcctttgcac ctgtgatgga
    12361 atctttttcc attgatgagg tatttctgga tatgacaggt acttctctga tctatcctga
    12421 ccctgtagct gctgctcatg agctgaaagg caagattcac agagagctgg gatttacagt
    12481 aaatgtagga atttctacca ataagctttt ggcaaagatg gcatcagatt ttcaaaagcc
    12541 ggacagagta cacactctgt tcccggatga aatcccggaa aaaatgtggc ctcttcctat
    12601 ccgtaatctg ctgtttctgg gaaaagcttc cgagcagaag cttctgaatc agggaatccg
    12661 taccatcggt gatctggcaa gagaaagagc atccaatgtg cagtactggc ttggggaaaa
    12721 aacgggacat cagctatggc aatatgccag aggtatcgat gattcccctg taaaagcagt
    12781 gcctgatgag gcaaaaggtt tcagcgtgga aactactttt aacgatgata ttacttccat
    12841 agagcaggtg tttcccatac ttttggagca gtgtgatgtt ctggcaacca gaatgcgcag
    12901 aaaagataag aaatgcaact gtatttccgt gactttccgt actttggatt tcagaaaccg
    12961 ttcacaccag acaaagctgg aaaatgctac agatcttaca gatgaaattt atataaatgc
    13021 tacaagactt tttaaagagt tctggaaagg acagccgcta cgtctgattg gtgtggcact
    13081 gacaggcctt acagatggca cttatgaaca gatgtctctg tttgaagata cagaaaataa
    13141 agaacgccac agaaagctgg atgcagctat ggatgagatc cggatgaaat ttggaaatga
    13201 taagatcacc cgtgccagta ttatgaacag caatgcacgg attgggcgaa aagcgaaagc
    13261 acagatgaaa aacgaaaaga tggaagaacc gtaagtaaag ggaggactga gcattaagaa
    13321 caatgcgaca atcctccctt tataaaaatt tcagaaaaag ttttatcgtt ccatcatact
    13381 gatagattcg attcctacac ttcctccacg taccacttca attctgtgaa attcttcctt
    13441 gatcagtttc actactgcgt cattcttggt tgctgtctgg acaaattcca ggagcaggct
    13501 gtctttgcca tagtcaatga cctttgcctt gaaggtttcg gcaatctgaa acagttcaac
    13561 cttatcttct ttggaacagt taaaaacctt aatatacaga atctctttca tgcggacaaa
    13621 tacgtctgtg aaatcaataa ccttaataac ctcgatcata cggttcaact gttttttgat
    13681 ctgctcaaaa gtttcatcat cactgacagt tgcgatcgtc attcgagata ctgtggggtc
    13741 ctcggtggtt cctacagtaa gactgtccag attgtagctt tttccggaga aaagtccgga
    13801 gattttggac agaacaccta cctggttctc aacatagaga gaaatccatc tttttttcat
    13861 tcctttatcc ataataattt tcctcctgat caacagtcca taatcatatc ttccagagtt
    13921 ccgcctggtt tgatcatagg ataaaccatt tcctcagggt caatgatgaa ttcaattact
    13981 gtaggtgcct ttgtgttctt ttttgcttcc tcgaaggctg ctgcaatttc ctcttttttt
    14041 gtgacacgga ttccttttgc cctgtagctc tctgcaagtc tgatgaaatc cggtgtgtac
    14101 tgtggatatt ccatgccttc agtgcggcgg gaaagtgctc ctgcgcgcag attggtcata
    14161 gcatagcgtt tgccgtagaa aagcttctgc cactggcgta ccattccaag atactcattg
    14221 ttaaagatac acaggataac cggaagctcc tccagaactg cagttgcaag ctcctgaatg
    14281 ttcatctgca caccgccgtc accggagata acgatgacag gtctgtcggg atttccgatt
    14341 ttggctccga tgccgcctgg aagaccatag cccattgttc ccagaccacc ggacatgatc
    14401 atctgtttgc cctctgtgat ttccgcatac tgggagacaa gcatctgatg ctgtcctaca
    14461 tctgttacga taatactgtt ctcaaattgt tcgttgatct ctttcaggat atccatcgga
    14521 cttaaaagat catttggacg cattttaagc ggatgctctt ctttccagtt tttgatcagg
    14581 ttaagccact tgtccgttga acattcctgg acgtattcgt tcattttggt gatagcctct
    14641 tttgcatcag caacaatggg gatatctacc tgaatgtttc gggaaatgga tgctgtatca
    14701 atatcaatgt ggataatctg ggcatgtggt gcaaattcat gaagttttcc ggtgattctg
    14761 tcattgaatc tggttccgat ggagaacagc acatcgcagt tgctgactgc catatttgct
    14821 gcataggcac catgcatgcc aaggtttccg atatagagtg gatggtctgt ggggatagag
    14881 ccttttccca ttacggttgt gacaaccggt acttttgtct tttccactac ttcccggaaa
    14941 atttcatggg cgcgggagat tactacaccg ccgcctgcca ggaataaggg acgttttgct
    15001 ttatttaaaa gtttgatggc acgtttgagc tggccgatgt ggacatctgt gtttggtttg
    15061 tatccgcgga tgtttacatt tttaggatat tcagcgctgc cgagttctgc cattacgtcc
    15121 tttggaaggt cgataaggac aggtcccgga cggccggtgc gggcaatgta gaaagcttct
    15181 ttgatgatac gtcccaggtc ttcacgtctg cggacagtaa caccgtattt ggtgatgctt
    15241 ctggtgattc ctacgatgtc tacttcctga aatgcatcgt tgccgatgag gtagcgggct
    15301 acctggccgg tgaagcatac aagaggtacg ctgtcatagt tggcggttgc aagtcctgtt
    15361 acaaggttgg ttgctccggg accgctggtt accagacata cgccgacttt gccggtggtt
    15421 ctggcgtagg cgtcggcttc gtgtacaagg gcttgttcgt gacgggggag gatgattttg
    15481 acgtcgtcct gtttatagag ttcgtcactg atgtcgatgg tacaggctcc ggggtagccg
    15541 aagaggtatt ctacgccttc ttcttttaag gctttgacta agagtttgtt gccggatatt
    15601 tgtttcatat ttgggtaaac ctcctttgtg tatgtggatg gggacgctca gaaatttatt
    15661 tgttttgtgt gcggtttcgg agtctagtat atctaagtgt ctgaaaatct gctaaaagcg
    15721 ttcagaaaaa tctcaaactc gctgcgctca gacagtgaga tttttctgaa caacgcagat
    15781 ttccaggcac caagatatac acgactcctg caaatgcaca caaaacaaat aaatttctga
    15841 gctgtgtgtt ggccaatgca gggggcagaa tggcgctgcg ctgattctgc cgagtgtggg
    15901 gtggcgggtt tgatgtgaca gattaaagca agcacgaacg actttttgac cctgatatat
    15961 aaatatagta aaaaacgccc tgggcttgtt tgcccagggc gaaaatgttt tccgcggtac
    16021 cacctgtatt cagagtctgg ctctgcactt tgtcagtact gatatactgt gttcctgtaa
    16081 cgtggaactg acgttgaagc ctacttggca tgtccgttca ggtcttgtgg atcagacggg
    16141 atatgcggtt tggttcactg ctcgggggct acttccacaa ttcgttcacg aaagctcgca
    16201 ccgaccgctt tctctctgtg cttcccggag ttgtgtactc ctccctgtca tggcatttgg
    16261 ctgatatgag gtattcattg tccgaatagg gtggacaaat gttttcttgg gttacattat
    16321 acatttatag agaggaaatt gtcaaccggg ttttggataa ttgctgtaaa atttatgttc
    16381 ctgaatgaat tttggctacg ttactgagaa cggagtgaac agtaatgtaa ttgacagatt
    16441 tctatattgc tgatataaaa aataaataat acagctgttt ggaaggttat taacagttaa
    16501 atataaatta taaaatcatg taagcacatg ttgagtttta caagatatta gagtagaata
    16561 ttattgaaag gagttgattc tttgagtaaa tattattcta tacatgaatt ttcaaaaatt
    16621 ataggcgtat ctgcccagac attacgaaat tgggat
//
