LOCUS       c00084_gnlPro..        13577 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NCELMIHK_84.
ACCESSION   c00084_gnlPro..
VERSION     c00084_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 03:18:14
            Original ID  :: gnl|Prokka|NCELMIHK_84
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 106261
            Orig. end    :: 119838
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13577
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[116261:118274]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..12013
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13577
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13577
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(1242..1370)
                     /locus_tag="ctg84_106"
                     /transl_table=11
                     /translation="MNEMNDKIIGNVEKELDEIEIIDTESIEEKLSFIVYGTIVCC"
     CDS             complement(1387..2868)
                     /locus_tag="ctg84_107"
                     /transl_table=11
                     /translation="MLKVLLYGLATFMETGIGVWIFSQTFSERRILEKKYYVLEWLLYS
                     LIFFGIYNFSVSLWQIDKKIEKYVIKVICIYIIGLIAGIIYDIFFVKKKEMVLRRILYI
                     GMIFWLTAQYWAGYQSLLMIILGSGIIVLYVFCYFDCTFKQAYVWNFFYAVNIGLIKEA
                     YVVYAGVFNHKQWDDFYSYPRGHTYQEVIFWILGCLFIFWIIKFILSVNSIKGILRTRL
                     KELFIIGLLEYVLLIVSIIYKFGTIKKENFVMTACLLAVSNIALIGVYVKFQKKTLEMR
                     NQILDMRCKLMEEEYEELRMSYDRYRCLVHDEKHLLLYIKECLENGELDSCITFLNHYK
                     RESIRYSGVAWTGIPEINFMLNIKVRKMEEKNIFFKVDSKIEKIPMKDIDFVVLLGNLL
                     DNAIEAAEKCEEGKGKITCIFRNINDMFIFKVKNTSIYKPYEKNTKFYTSKKEKDEHGW
                     GIESVKQIVRKYNGEIDFKYDKDFFEVEIIISDNT"
     CDS             complement(2872..3579)
                     /locus_tag="ctg84_108"
                     /transl_table=11
                     /translation="MIRIMILDDDEMYLKKEKDITEQYFAEKNVDCTVTIYQNVEWFLL
                     GLNEEKFDMYILDIRMPGENGIEAAREIRRLYPDPVIIFITNFVDYAIEAYEVNTYRYI
                     PKECLKEKLPQAYDALLPGIMEKEERYYIINKRNEVEKLAYSDIFYMKKEGKYVIFVHR
                     RGEVKIRASLSTVEKELNSKEFIIFDRGYLANIQHVMKMKGRDLYMRDGNIITVGRERF
                     KGVREAILNYWGV"
     CDS             complement(3585..4139)
                     /locus_tag="ctg84_109"
                     /transl_table=11
                     /translation="MDEYTKDLYTMMFSLQTLQNQGITIRETVYKSLDKLLLWNKESEN
                     SKYLELALLHMQAYANMGFALDEENKTIREILKKTGKTREDFFPKGYLLGKRIKLTKSQ
                     VRGMIGRWRPSRDSPMTIGELVDDIIRKVKNHEEGRYIYQYHRTDVTTKGDIEVYELVI
                     NKDESYFYDVKKFRFYTFMEE"
     CDS             4258..4593
                     /locus_tag="ctg84_110"
                     /transl_table=11
                     /translation="MKNNTIGKRIAEARINRNITQEHLEELSGLSVSTISRIETGKYMP
                     TIENLLKLSEILDVGLDYFLYDLLPHNKDIQSPAIQDAISIMNQMGERQTEYIVKILKI
                     YQASHQD"
     CDS             4780..5673
                     /locus_tag="ctg84_111"
                     /transl_table=11
                     /translation="MTKTEKAVTWAIEIANDPAHGYDQDNRWGPDYDCSSLVISAWQQA
                     GVPVKTKGATYTGNMKSVFLSCGFKDVTSKVNLSTGSGMKRGDVLLNIASHTVMHIGNG
                     QVVSASKNENNGYHGGKPGDQSGKEIKLQNYYNFPWDCVLRYTKDSSTTDPDPEPQPTA
                     GNAKIRKGQGYANKFANAGISITGKRDAATKKAGVKVLQTALNRDYGAGLDVDGIWGTN
                     TDNALGQHYVKNGETQYMVTAAEILLLLRAYDPNGVEIPGTFGSGLLSAVKAFQKAQGL
                     TVSGTCDRNTFLKLIS"
     CDS             complement(5815..6573)
                     /locus_tag="ctg84_112"
                     /transl_table=11
                     /translation="MKQKKIVIIMAGILAAAAAMTGCAEQNKTATQVDYTQNSQGKSEQ
                     TKQKTAEKSQPDKKQVNKSTFDGKENSNQTADKKTKVFASSNNAGDVQNSGNGTDGTAG
                     TDTDDSQTTGVDTSTSEDNGSTGNDGTQSDQRADQAMIYDSEGNGRLISEADDGNWYDS
                     DGNYYGSWEDIEDAMVNENGVTDQDGNKYYWTAPHDASEEVTDPYDLYSWDPGTNSYIP
                     FQAAESDCSPIGRGNGWYYYDEDSGEYVPW"
     CDS             complement(6855..9536)
                     /locus_tag="ctg84_113"
                     /transl_table=11
                     /translation="MKSNYKIFTAVFLSAIMTAAAPLTVCGAEVFSAGESFSDGTGSIP
                     AILTDMVLPDGEIGTEYQVQLEADTDVNWSLEEGSELPAGLTLSSGGVISGTPQEEGSF
                     SFTVQADNGIGVSSQELSLYVAQREQEPVIKQYELTSGTALIDLGIHAEGEQSRKRLFL
                     YNAGTDSLHLSDFPQSRYFDFSYAPIFDTNTDEEMQPGSCAAVDIDDKKDLPAGNYEET
                     VTFETKEGASCKVTLKVIVGASSEKDYELSIETGTEEEFTESDFYDPEFRVEKYVVVRN
                     SGKKETRIRVDTSGLKNFEVDDQMAKWTEDYEEQDSKKLLKPGETLYFYILPKQEYGIY
                     DETFAFLADDGSRYPLHVTMNREKNPTEKKQLEITEKSAGAFPTMQWGYKTLPEAKTYI
                     LKNVTDTDMKLSFNRSKECSVSLSGNAYLAPGESTELRLLPKLGLSVGKYSFQVTVTAK
                     TVAGEHLTTQNLYNSFIVGDRTYQGLADAVEPVTGITNGTEKTADALHLPDWLEVYGAE
                     VDGKKTTFSASVKWDVEDCVYDPKSKAAQSFTVTGHLELNEDENNEGLDTAVQIMVQVD
                     AYQTLNRPVIDLLRTGVRTNYAMLYLRDLSNEADGYQFVTAKSQKDLKKGNYTAQTKIT
                     NSELNQYPELKYIPEGTHSLYCRAYKENSSHVMEYGEWSDGVPVTVKVKTPDAPVVQKV
                     QVKKNDVRIVLNSKGEEPDGYDVVAARSKNGKEPSDYIKVKSGYSGSSKELILRGVPAG
                     TWYIGVHAYKYLNGSNTKVLSKWAEVRKVTVKTSLVTGKPAVKSTKVSRQGTKRNVTVT
                     FTAPKSCDGTDWVLAKKVSKSDDGSYTGVSSYAYTKKNQTKTTVVFKSVKPGVYYLAGR
                     AYVKGYAKSYTKWSKIKKIVVK"
     CDS             complement(10001..11152)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg84_114"
                     /sec_met_domain="HGD-D (E-value: 2.2e-87, bitscore: 286.6,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIIKDLPEVFEEFAEQRKNSFLAIKKIKDQNIPVIGSYCTYFPQ
                     EIAMAMGAASVGLCSMSDETIPVAEQTLPKNLCPLIKASYGFAVTDKCPFFYFSDVVVG
                     ETTCDGKKKMYEFMSEFKDVFILELPHKQTEAALQYWKSEIIRFKEYLEKKFEVEITEE
                     KLREAVRISNEGRRALKDFYELMKQDPAPMKGENLYNVLYGTTFKFDRSKVPAEIDALT
                     VKLKEEYAAGKNEGKKHRILITGCPMGGATMKVVKAIEENGGVVVAFENCSGAKSVDRL
                     IDENDPDIYEAIARRYLNIGCSVMTPNPNRFELLNELIDEYQVEAVVEMTLQACHTYNV
                     EAGKVGRFVREEKKIPYLHVETDYSQSDVGQLNTRIAALIEML"
     CDS             complement(11252..12013)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: FGGY_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg84_115"
                     /sec_met_domain="FGGY_C (E-value: 4.5e-07, bitscore: 22.7,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.2e-49, bitscore:
                     162.1, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LYYVGIDIGSTASKTVVTGDREMKFVLPTGWSSKETASEIASRLL
                     DEGIDVMSEGVRVAATGYGRVAVDYADFVITEITCHGRGGRELAGNECAIIDVGGQDTK
                     VILIDQGMIQDFLMNDKCSAGTGKFLEIMANRLGVTIAELFDLAEQGTVVPISSLCTVF
                     AESEVISMIGEGRSREDIAAGVVNSVAEKVAQLARRKQLPGTVLLTGGLSECPYFAEIL
                     SEKLGCAVEAMKDGRYAGAFGASLLAGEKKK"
     CDS             complement(12341..13309)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg84_116"
                     /sec_met_domain="F420_oxidored (E-value: 8.2e-07, bitscore:
                     22.5, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 4.3e-25, bitscore:
                     81.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLGILGAGGIASTMAKTVAGMKDVEAYAVAARDLGRAQVFAQKY
                     EVKKAYGSYEEMLADDEVELVYIATPHSHHYLHAKMCLEAGKHVLCEKAFTVNAEQAQK
                     LFDLAKEKKLLITEAIWTRYMPSRKMINDIIESGVIGEVTAVTANLSYTVSHVERIRKP
                     ELAGGALLDVGVYPINFASMVLGDKVKDVKATAIFQNGVDILDSIAMVFEGDRMATLQC
                     GAREISDRMGSIFGTRGYMQVQNINNPEKITVFDTEHKEVASYVVPEQISGYEYEVESC
                     KKAIHEGKPECPEMPHAETIRIMKILDDIRKSWNYEIPCIE"
ORIGIN
        1 cataaaagaa gattccccct ctttgtgaat cacattcaaa agagctttcc tgcattctct
       61 tgacttcata taatccggat gaaacgaagc cataagatac attgcatact gttgggtatg
      121 ccgcagtaca actctggaac gtccgtcaaa aaagccggac aacatcacct ccactttctt
      181 atctgccatt gccaccatgt acgctctgca aaatcctctg ataatgcatt ccgtataatc
      241 tgccgcattg ataacctgat catttagtct tacaatgcat tcctttatct gcatttccac
      301 aggttcatat tctatgtgga tatcagatgt tttatcatcc tttaccacag gaagtttaaa
      361 cggtgttttt atcttttcct ctgttcccat tgcacttata agaactcctc tgtttcctct
      421 gccccatgtg agaacaggaa gcattcctgt atgtataacc gaatttgcca attttatctc
      481 tgtacttttg tttatttttt cttctacact acttccgtct ttctctgatt gttgttttaa
      541 atatcccgga tatgtctcca tatcgataat cacaggatat tctccatgtg caataatatt
      601 ttcaccatga agatctgttg ctccgagggc atatcccaaa aacagatgta tgcccattct
      661 gaaataataa tgctccacct cactttcgtt tttacaggga atattctcaa ttttttcttc
      721 ccatccatag gaatcatgag ataaatattg taccgtcctg caggaaattc ctgtttttct
      781 gcataaatag ttataaagtt cctgatattt tatattctta tcaagactat gtggcttata
      841 gtacagaatt gttccattat ccaattctac cttcgccaca cttcgtcctc ctctgtgtat
      901 atcgcctttc gacatgtaaa ttcccacagt cccggaaaac tttcttccat cacagaatat
      961 tttttgtatc tgttcttttt ctgcataaag agatttcctg atttcacatt ctgctctctg
     1021 gatagagtta tttttcaatt caagcagacg ttttaactcg ggatattcct gcagtaaaga
     1081 ttttacatat gttgcattgt taagatattt tttttcataa taatcatatt gttcttttgg
     1141 cgtacttcct tttagatttc caaaattttt ctgccgatgt acatctaaga ttaatatttt
     1201 aagaaacata gttcgatttt ttctgcataa ataatccaat ttcagcaaca cactatagtt
     1261 ccatatacaa taaaagacaa tttctcttct atactttccg tatctattat ctctatttca
     1321 tctaattctt tttccacatt tcctattatt ttatcattca tttcgttcat aaccgtcact
     1381 ctcccattat gtattatcgc taattattat ttctacttca aaaaaatctt tatcatattt
     1441 aaaatctatt tcaccattat actttcttac aatttgtttg acactttcaa tcccccatcc
     1501 gtgctcatct ttctcttttt tacttgtata aaatttagtg tttttttcat aaggtttata
     1561 tatgcttgta ttctttactt taaaaataaa catatcatta atatttcgaa aaatacacgt
     1621 aattttacct tttccctctt cacacttttc agcagcttct attgcattat ccaaaagatt
     1681 tcctaggagt acaacaaaat ctatgtcttt catcggaatt ttttctattt ttgaatctac
     1741 tttaaaaaaa atattctttt cttccatttt tcgcactttt atattcaaca taaaatttat
     1801 ttctggaatt cctgtccacg ctactccact atatctaatg ctttctctct tgtaatgatt
     1861 caaaaaagtg atacatgaat ccagttctcc attttccagg cattctttta tatataaaag
     1921 caaatgtttt tcatcgtgca ccaaacaccg ataccggtca tatgacattc tcaattcttc
     1981 atattcttct tccattaatt tgcatctcat atctaaaatc tgatttctca tttctagggt
     2041 ctttttttga aacttaacat atacaccaat caatgctata ttactaactg ctaataaaca
     2101 tgcggtcatt acaaaatttt cctttttaat cgtaccaaat ttgtatatga tgctaactat
     2161 taataaaaca tactctaaca atccaataat aaaaagttcc ttcagacgtg tacgcaatat
     2221 tccttttata ctgtttactg acaaaataaa tttaattatc caaaatatga ataaacagcc
     2281 taaaatccaa aatataactt cctgatatgt atgtcctctc ggatatgaat aaaaatcatc
     2341 ccactgttta tggttaaaca cccctgcata tacaacataa gcctctttta tcaatcctat
     2401 attaactgca tagaaaaaat tccaaacata tgcctgttta aatgtgcaat caaagtagca
     2461 aaaaacatat aatacaatta ttccactccc aagaataatc attaacaacg attgatatcc
     2521 agcccaatac tgagcagtta accaaaatat catgccgata tataatattc ttcttaagac
     2581 catctccttt ttctttacaa aaaaaatatc atatataatt cctgcaatta atccaattat
     2641 gtatatacaa ataactttta tgacatattt ttctattttt ttatcaatct gccataatga
     2701 aacagaaaaa ttataaattc caaaaaaaat caaagaatac aacagccatt ctagaacata
     2761 atattttttt tctaatattc ttcgttcaga aaacgtctgg ctaaatatcc agacacctat
     2821 ccctgtctcc ataaacgttg ccagtccata caataaaact ttcagcattc ttcatacccc
     2881 ccagtaattc agaattgctt ctctgacacc tttgaatctt tctctgccaa ctgtaataat
     2941 attaccgtcc cgcatataaa gatcccttcc tttcatcttc atcacatgtt ggatgtttgc
     3001 aagatatcct ctgtcaaata taataaattc ttttgaattc agttcctttt ctactgttga
     3061 cagacttgct ctgatcttta cttccccacg cctgtgcaca aaaatgacat attttccttc
     3121 ttttttcata tagaaaatat cagaatatgc cagtttttca acttcatttc ttttatttat
     3181 gatatagtac cgctcttctt tctccataat tccaggaaga agcgcatcat aagcctgcgg
     3241 aagtttttcc ttcagacact ctttggggat ataacgatag gtgtttacct catatgcttc
     3301 tattgcataa tccacaaaat ttgtaataaa tataataacc ggatccggat aaagtctgcg
     3361 aatttccctc gctgcctcta ttccgttttc tccaggcatc cggatatcca gaatatacat
     3421 atcgaatttt tcttcattca atcccagcag aaaccattcc acattctggt atatcgttac
     3481 cgtgcaatct acgtttttct ctgcaaaata ctgttctgtg atatcctttt cttttttcag
     3541 atacatttcg tcatcatcca gaatcattat tcttatcata gcaattattc ctccatgaat
     3601 gtataaaatc tgaatttctt cacatcataa aaataacttt catccttatt gatgaccagc
     3661 tcataaacct cgatatcccc tttggttgtc acatcagttc tgtgatactg ataaatgtat
     3721 ctgccttcct catggttttt tacctttctg atgatatcat ccaccagttc tccgattgtc
     3781 atcggactgt ctctggaagg tctccatctt ccaatcatac cacgaacctg tgacttggtc
     3841 agtttaattc tctttccaag aagatatcct ttcgggaaaa agtcttctct ggtctttcct
     3901 gtctttttta atatctcacg tattgtctta ttttcttcat ctaaagcaaa tcccatatta
     3961 gcataagcct gcatatgaag caacgctaat tcgagatatt tactgttttc agattcttta
     4021 ttccataaca gtaatttgtc cagactttta tatacagttt ctctgattgt aattccctga
     4081 ttttgcaaag tctgcaaaga aaacatcatg gtatacaaat cctttgtata ttcgtccata
     4141 ttcctatatt cctcctgtca taaaacatat caaatttgat tagtcgcttg tcatttatat
     4201 ccttatacat atttaattcc gtctgttaaa ctttatcaaa ggaaaggatt tttatttatg
     4261 aaaaacaata ctatcggaaa aagaattgca gaagctcgga tcaacagaaa tattacccag
     4321 gaacacctgg aagaattaag tggtttatct gtaagtacga tcagccggat tgaaacaggt
     4381 aagtatatgc ctactattga aaatctcctt aagctttctg aaattcttga tgtgggactt
     4441 gactattttc tttatgatct gcttcctcat aataaagata ttcaaagccc ggctattcag
     4501 gatgcaattt caatcatgaa tcaaatgggt gaacgccaga ctgaatacat tgtaaaaata
     4561 ctgaaaatat accaggcctc tcatcaggat taaatataat tacaattcga caattttcgt
     4621 gtttttgtcc tcgaaaagca tttttctgac ctcgaagcaa caatcaggaa atgcttttta
     4681 ttttttctgt ttcatgttta catttttccc ttttctcact ctttataaga tgtatcaccg
     4741 gtgagcaaat aaataatcaa atttcaggag gataaaaaaa tgacaaaaac agaaaaagca
     4801 gtaacatggg caattgaaat cgcaaacgat ccggcacacg gatatgatca ggataacaga
     4861 tggggaccgg actacgattg ttcttcactg gtaatctccg catggcagca ggctggtgtt
     4921 cctgtaaaaa caaaaggagc cacttataca ggaaatatga aatccgtctt tctgtcctgc
     4981 ggctttaagg atgtgacttc caaagttaat ctcagcacag gaagtggcat gaaacgtggt
     5041 gacgtattat taaacatcgc aagtcataca gtaatgcaca ttggcaatgg tcaggtggta
     5101 tctgccagca aaaatgaaaa taatggatat catggtggta aacccggaga tcagagtgga
     5161 aaagagatca aacttcagaa ttattacaat ttcccttggg attgtgttct ccgttatact
     5221 aaagattctt caactactga tcctgatcct gaacctcagc caactgcagg aaatgcaaaa
     5281 atccgcaaag gtcagggtta tgccaataag ttcgccaatg caggaatctc tattaccgga
     5341 aaaagagacg ctgctaccaa aaaagcaggc gttaaagttc ttcagacagc tctgaacagg
     5401 gattatggtg ccggtctgga tgtagacggt atctggggaa caaacacaga caatgctctt
     5461 ggacagcatt atgtaaaaaa tggtgaaaca caatatatgg taactgccgc tgagattctc
     5521 cttcttttac gtgcttatga tccaaacggt gtagagattc ccggtacctt tggctcagga
     5581 cttctctctg ctgtaaaggc attccagaag gcacagggct taacggtttc cggaacctgt
     5641 gacagaaata ctttcctgaa actgatcagc tgatctttac cagataaaca tccggcagaa
     5701 ttcttttcac tgattctgcc ggatatgccc ctttactatt tcttgtatat aaaaagaaac
     5761 agttttgaaa cccatcaaaa tgatttcaaa actgtttctt ttgttttctt atttttacca
     5821 cggaacatat tcgccgctgt cttcatcata gtaataccag ccgtttcctc tgcctatagg
     5881 actacagtca gattccgcag cctgaaacgg tatataggaa ttggttcccg gatcccagga
     5941 atacaggtca tacggatctg tgacctcttc tgatgcatcg tgaggtgctg tccagtaata
     6001 tttattgcca tcctgatctg tgacaccatt ttcatttacc atagcatctt caatatcttc
     6061 ccagcttcca tagtaatttc cgtcactgtc ataccagttt ccatcatcag cttcagaaat
     6121 cagccttcca tttccctcac tgtcatatat cattgcctga tctgccctct ggtcagattg
     6181 agtaccatca ttacctgttg aaccattatc ttcagatgta gaagtgtcca cccctgtggt
     6241 ctgggaatca tctgtatcag ttcccgcagt accgtctgtt ccattccctg aattctgtac
     6301 atcgcccgca ttattggatg aggcaaatac tttcgtcttc ttatccgcag tctgatttga
     6361 attttctttt ccatcgaatg tacttttatt tacctgtttt ttatccggct gagatttttc
     6421 tgctgttttt tgttttgtct gttcggattt cccctgtgag ttctgcgtat aatcaacctg
     6481 tgtcgctgtt ttattctgtt ccgcgcagcc cgtcatagca gccgctgctg ctaaaatccc
     6541 tgccataata attacaatct ttttctgctt cattttgttg tcctttctac atttactaaa
     6601 aatgtcattg cctttatcat aatgtgcttt tcctgttcat tattacatac tccacaggct
     6661 tcgatgcctc atatgtccct tatctgtcat aaaaaggaca ttatttatct ccaaattcag
     6721 acaagatttg agtataataa gtggcagtac cgtaaacttt gagtattaca ggaaaaagca
     6781 ggtataaacg cctggtaaaa gggggatttt tcttcttaaa agtgaaatct ctgtgaaaca
     6841 aatgacagca gtgcttattt cacaactatt ttctttattt tcgaccattt cgtataactt
     6901 tttgcatagc cttttacata ggcacgtcct gcaaggtagt agactccggg cttcacactt
     6961 ttaaagacca ccgtggtttt tgtctgattt ttctttgtat aagcataact gcttacacct
     7021 gtatagctgc cgtcatcaga tttggaaact ttctttgcca gtacccagtc tgttccatca
     7081 caggactttg gagcagtaaa cgtcaccgtt acatttcttt ttgttccctg tctggaaacc
     7141 ttagttgatt taacagcagg ttttcctgtt acaaggcttg tttttacagt taccttcctg
     7201 acctctgccc atttactgag cactttggta ttgctcccat tcagatattt ataagcatgt
     7261 acgccaatat accacgttcc tgccggtacg ccccgtaaga taagctcttt actgcttccg
     7321 gaatacccac tctttacctt tatataatcc gatggttctt ttccgttctt acttctggca
     7381 gcaacaacat cgtaaccgtc cggttcctca cccttgctgt taagtactat tctgacatca
     7441 tttttcttca cctgcacctt ctgaaccaca ggtgcgtccg gagtctttac ctttaccgta
     7501 accggaaccc cgtctgacca ttccccatat tccataacat ggctgctgtt ctctttgtat
     7561 gccctgcaat aaagactatg tgttccctcc ggaatatact tcagctcagg atattgattc
     7621 agttcagaat ttgtaatttt tgtctgcgca gtataattcc cctttttcag atccttctga
     7681 gatttggctg tcacaaactg atagccgtct gcttcattgg aaagatctct cagataaagc
     7741 attgcataat ttgttctcac tccggttctc aataagtcaa taaccggtct gtttaatgtc
     7801 tgatatgcat ccacctgtac cattatctgt acggcagtgt ccagtccttc attattttca
     7861 tcttcgttca gttccagatg accggtcact gtaaaacttt gagctgcctt gcttttcgga
     7921 tcatacacac aatcctccac atcccacttc acagatgcag aaaatgttgt tttctttcca
     7981 tccacctcgg caccataaac ttccagccaa tctggcagat gcaaagcatc agctgttttt
     8041 tctgtgccat tggtaattcc ggtcacaggc tcaacagcat ctgccagtcc ctgataagtc
     8101 cggtctccta caataaaaga attatacaga ttctgcgttg tcaggtgttc tcctgccact
     8161 gttttcgcag tcacagtcac ctgaaaacta tattttccca ccgaaagccc cagttttggc
     8221 aagagtctca gttctgtgct ctccccaggt gccagataag catttccgga caatgacaca
     8281 ctgcattctt tactgcggtt aaaagacagc ttcatatctg tgtcagtaac atttttcaga
     8341 atatatgtct ttgcttccgg aagtgtctta taaccccact gcattgtcgg aaaagccccg
     8401 gcagactttt cagtaatttc cagctgcttc ttttctgtcg gattcttctc tctgttcatt
     8461 gtaacatgaa gaggatatct gcttccgtca tctgcgagaa atgcaaacgt ttcatcataa
     8521 attccgtatt cctgcttcgg caatatataa aaataaagcg tttctcccgg tttcagcagc
     8581 tttttggaat cctgttcctc ataatcttct gtccactttg ccatctggtc atccacttca
     8641 aagttcttaa gaccggaagt gtctacccgt attctggttt cctttttccc tgaatttctg
     8701 actactacat acttctccac acgaaattcc ggatcataga aatcgctttc tgtaaactct
     8761 tcttctgtac ctgtttctat actcagctca taatcttttt cagaggaagc tcccacaatt
     8821 actttcagag taaccttaca ggaagcacct tcttttgtct caaatgtcac tgtctcttca
     8881 taatttccgg caggcagatc cttcttatca tcaatgtcca cagccgcaca acttccgggc
     8941 tgcatttctt catccgtatt tgtatcgaaa atcggtgcgt aggaaaaatc aaaatatctg
     9001 ctctgcggaa aatcagagag atgaagcgag tctgttcctg cattataaag aaataaccgc
     9061 ttacgtgact gttctccctc tgcatgaatt cccagatcga tcaaagcagt acctgatgtc
     9121 agctcatact gctttataac aggttcctgc tcacgctgtg caacataaag gctcagttcc
     9181 tgtgaagaaa ctccaatacc attgtccgcc tgtacagtaa agctgaaact cccttcctcc
     9241 tgcggtgttc cgctgatcac tcccccggaa gacaacgtaa gtcccgccgg aagctcgctt
     9301 ccctcctcca gactccagtt cacatctgta tcagcttcaa gctgtacctg atattccgtt
     9361 ccaatctctc catccggcag aaccatatct gtcaatatgg caggaatact ccccgttcca
     9421 tcactgaaag attctcccgc cgaaaaaact tccgccccac atactgttaa cggagctgct
     9481 gctgtcataa ttgccgataa aaaaactgct gtaaaaattt tgtaattact tttcattctt
     9541 ctcctccaga taataaaata taaaagtatc aatttaacta attaatatta atataccact
     9601 ggacggaaat gtttctgtaa ttacggaatg atatgtagtc taatggtcat gaatatcaga
     9661 aaagccctgt ccgccggaaa aattcatccc acagagagag cttctgtttt ctgtccatat
     9721 tttttagttt ctggtttata aatttgatca gtcgcttgtc atttattgct tatacatatt
     9781 tttttctata gcaatcctcg taaataatgc atttaagaca gttcagcaga gcgcgaaaga
     9841 caaggaagat atctgcaggc gcgctgacgc acggcaaaga tatctgacgc aggatttcac
     9901 actctgatgg gctggattaa gatgcattat ttcagaggat tgctataata aaatacatac
     9961 aattcgacat ttttcgtata atcttataat accttcacag ttataacatt tctatcagag
    10021 ccgcaatacg tgtatttagc tgtccaacat cagactgaga ataatctgtc tccacatgca
    10081 gataaggaat ctttttctct tctcttacaa atctgccaac tttaccggct tccacattat
    10141 aagtatgaca ggcctgaaga gtcatttcca caacagcttc tacctggtac tcatcgatca
    10201 gttcatttaa cagttcaaaa cggttcggat tcggagtcat aacagaacag ccgatattca
    10261 gataacgtct tgcaattgct tcgtaaatat ccggatcatt ttcatcaatc agtctgtcta
    10321 cgctctttgc accggagcag ttttcaaaag caactaccac accgccattt tcttcaattg
    10381 cttttactac tttcatggta gctccgccca ttggacatcc ggtgatcaga atacgatgtt
    10441 tctttccttc gtttttgcct gctgcatatt cttctttcag cttcactgtc agtgcatcaa
    10501 tctctgccgg gactttggaa cggtcaaact taaaggtagt tccatacaat acattataaa
    10561 gattctcacc cttcattgga gccggatcct gtttcatcag ttcatagaaa tctttcaaag
    10621 cacgacgtcc ctcattgctg atgcggactg cctcacgaag cttctcctct gtgatctcca
    10681 cctcaaattt cttctccaga tattctttga aacggataat ctcactcttc cagtactgaa
    10741 gtgcagcctc tgtctgttta tgaggaagct ccagaataaa tacatcctta aattcggaca
    10801 taaattcata catttttttc tttccgtcac aggtagtctc accaactaca acatctgaaa
    10861 aataaaagaa tggacattta tctgtcactg caaacccata actggccttg atcagtggac
    10921 agagattttt cggcaatgtc tgctcggcta ccgggattgt ttcatcagac atggaacata
    10981 aacctacaga agcagctccc atggccattg caatctcctg tggaaaatat gtacagtaag
    11041 aaccaattac cgggatattc tgatccttaa tcttcttgat agcaagaaat gaattcttcc
    11101 tctgctccgc aaactcctca aatacttctg gtaaatcttt aattatttcc atctttgtac
    11161 ctcatctttc tatcgttttt atattatttt ttacttcttt cataccattc gccaactgtt
    11221 gcagtcctta ttatcctcta cagttgatta tttatttctt tttttctccg gcaagcaatg
    11281 atgccccaaa cgctcctgca tatcttccgt ctttcatagc ttcaacagca catccaagtt
    11341 tttccgaaag aatttctgca aaatacggac attcactcaa tcctcccgta aggagcactg
    11401 tccccggaag ctgctttctt ctggcaagct gcgcaacttt ctccgctaca gaatttacca
    11461 ctcccgcagc tatatcctct ctgcttcgcc cttcaccaat catgctgatt acctcagatt
    11521 ccgcaaatac cgtacacaac gaactgatcg gtaccacagt tccctgttct gccaggtcaa
    11581 acagttccgc aatggtaact cccagtcgat tcgccataat ctccagaaac ttcccggttc
    11641 cggcagaaca tttatcattc ataagaaaat cctggatcat tccctgatct atcaagatta
    11701 ctttcgtatc ctgaccacct acatcaataa ttgcacattc atttcccgcc agttctctgc
    11761 cacctcttcc atgacaggta atctccgtaa tcacaaaatc cgcataatcc acagctacac
    11821 gcccatatcc tgtagctgct acacgaaccc cttcactcat tacatcaatc ccctcatcca
    11881 gaagccttga agcaatctcc gaagccgtct ccttactgct ccaccctgta ggtagcacaa
    11941 atttcatttc cctgtcacca gtcacaactg tcttcgaagc agtcgaacca atatcaattc
    12001 caacataata caacttttct cacctgcttt ttttggtatt tttatccatt ctgtttactg
    12061 taacttctat tatacccttt cccattaata atcaaaaatt caaaaataca ataaaagcag
    12121 gagatttatt taaaaaagct ataaatgatt tttaccccac gaacaagcaa tgacacacga
    12181 cagataatga taaaatcctc tttataaatt tatctggtaa aatcaagaca caataaattt
    12241 ttttgttaca tttccattat agcagaaaag aaaaaccagt aacgtttcgg gtatatgtca
    12301 aaacattact ggtctttttt ataagattat tccacacttt ttattcgata cagggaatct
    12361 cataattcca ggatttacgg atgtcgtcca ggattttcat aatccttatt gtttccgcat
    12421 gaggcatttc cggacactcc ggttttccct catgaattgc tttcttgcag gattctacct
    12481 catattcata tcctgagatc tgttccggca caacataaga agccacttct ttatgttcgg
    12541 tatcaaacac tgtaattttt tccggattat tgatattctg cacctgcata tatcctctgg
    12601 ttccgaaaat acttcccatt ctgtctgaga tttctcttgc tccacactga agggttgcca
    12661 tgcggtctcc ctcaaacacc atggcaatgc tgtccagaat atccactcca ttctgaaaga
    12721 ttgcagtagc ctttacatcc tttaccttat cgccaagcac catggaggca aaattaattg
    12781 gatatactcc tacatccaga agagcacctc ctgcaagctc cggtttacgg atacgttcca
    12841 catgacttac tgtatagctg agattcgcgg taactgccgt aacttctccg atcacaccgc
    12901 tttcaataat atcgttgatc atctttctgg acggcatata tcttgtccag attgcttctg
    12961 tgatcagaag ctttttctct tttgcaagat caaataattt ctgtgcctgc tctgcattta
    13021 cagtaaatgc cttttcacaa agcacatgct ttcctgcttc cagacacatt ttcgcatgca
    13081 gataatggtg tgaatgaggg gttgcgatat aaaccagttc aacctcatca tctgccagca
    13141 tttcctcata ggatccatat gcttttttta cttcatattt ctgtgcaaat acctgggctc
    13201 gtcccagatc acgggcagca accgcatacg cctccacatc tttcattcct gccactgttt
    13261 tcgccatagt agaagcaatg ccccctgctc ccagaatacc taacttcatt ttactgtccg
    13321 ttactgaaaa cttataaaaa gttataaact tctatgtttc attcctactt caacgagtat
    13381 gcttttgatg atataaatat ctatctactc acaagttctt gtaccctcca taggcgtaaa
    13441 ttccggacta acgtatccgt acatatttgc attaacgttt cagtgtcagc ctgcaaattg
    13501 ttctccataa gtcttgagat ttatagatgc ctggaaatct ctgtcaatca tattcccaca
    13561 cgcacatcta taaactc
//
