LOCUS       c00009_gnlPro..        15668 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IACLKOLK_9.
ACCESSION   c00009_gnlPro..
VERSION     c00009_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 02:30:54
            Original ID  :: gnl|Prokka|IACLKOLK_9
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15668
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15668
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4366:8923]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4367..8923
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15668
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15668
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(65..2953)
                     /locus_tag="ctg9_1"
                     /transl_table=11
                     /translation="MRCNAFVEAWKNHHRRASMILGLSLLSAPLSYSVYAEDGVSNTMV
                     QVVTQTKTVKGTIIDESGEPLIGVSIVVKGTSTGTITDFNGNFSINLPAGRKELVISYI
                     GYKEQTVTVTGNGPVNVKMISDTQALDEVVVIGYGAVKKRDLTGAVASVKSEDITMNPG
                     TNPMEALQGKVAGLDITRESGQAGSGVKMQLRGNRSLTASGNPMFIIDGMPGDYATLNP
                     NDIESIEVLKDASSTAVYGSSGANGVVIITTKGGKEGKLTANFNAFFGINSWSTMPEVR
                     QGETYMEGLRTAHKNAGTYVDDANMFTNPAYYEAYQNGKYIDWVDELLHTGTVQNYSLS
                     VSGGTKNTKAYMSMNFSDENGQYNDDNYKLYSTNIRIDHTINKWFTTGISIQASYVHQN
                     KPFAKIQDGMTAIPYGEIYDENGNVNPYPIEGDAGYLNLLMNNKSNWRNQSQNTKLYVN
                     PYIKITPIKGLTWESRVNGTLTYSRSNSFQGDGSYNFYKAGGNVETDTNAKITQNRSYN
                     YKWENIVTYNFNIAKIHEFTLTGVSTWNHNQTDNTEMTGTGIANNKYLWEGLEKAAVQK
                     NSSSYTMSKGVGLVGRINYSLLGRYLLSASIRRDGSSRLAKDHKWSNFPAVSLGWRISD
                     EKFMESTRNWLDNLKIRVGYGISGTASIDPYSSSSSLESGWLTLGGEKTQIYNLTKIIA
                     NPELTWERSKNTNIGIDASFLNNRINVTLDMYKTKTEGVIWKKSLPVVNGSYSSKEQYL
                     TNINLCETKNKGLELALNTRNIETKNFQWTSALTFAYNKEEITKLTGTANDKVINGDYT
                     YAVGSAINSFYHYKLDGIWQKGEEADAAVFGLKPGSIKINVPDMVRHTDTDGSVYYTKV
                     NADGQEIRYDASNTYSVSADDYQVLGHNSPDWTMGFQNTLTYKDFDLSIYMYMRWGQMI
                     KYSVLTDYDPTGLNNYPTYFNVWSETNPSSVW"
     CDS             3193..4191
                     /locus_tag="ctg9_2"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNAFHSKELFQIYEATPGYTPLLIVA
                     TEDGRPMARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEVFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRANDYFPINWLRVRNSLHSMKKTEDRFSPSRI
                     RQIKKGLKNGAKVEEAHTVEEIHDFSRMLHKVYSSRIRRYFPANDFFRHMNNMLIKGQQ
                     AKIFVVKHKEKIIGGSVCIYSGDDAYLWFSGGMRKTYALQYPGVLAVWKALEDARQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRVNWNWLNKLLVKFYV"
     CDS             4367..4771
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_3"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.4e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             4800..6353
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_4"
                     /sec_met_domain="CT_Btheta (E-value: 2.1e-290, bitscore:
                     953.0, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             6385..7305
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_5"
                     /sec_met_domain="OAD_gamma (E-value: 7.2e-16, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILINNQSNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGKKLLDQIVVPAGALGPNQSYARVSDGAAEW
                     EVKSGSGDKYVTPSTNNKTLDSNSKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             7330..7761
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_6"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.2e-22, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPV
                     AKPVTVRPMPNAPAAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             7763..8923
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_7"
                     /sec_met_domain="OAD_beta (E-value: 7.4e-154, bitscore:
                     501.6, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLVFIYLAIAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFVIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             9229..10569
                     /locus_tag="ctg9_8"
                     /transl_table=11
                     /translation="MKRIIILFFLCSTIPLIAQHTDPIQEAMANYDYETALSLIAQKKS
                     TPPLLLQKGKALRGLGLTTEALATYQEIIRNDTTNTRAFIEAAECCRTLANYNQALKYY
                     EHALDLNPENKYARIQYISLLLSQQKFREALGESSLMTEKDSSAIALHLQAQSFEGMGE
                     LLPAAGCYYNIQAKYPDDYLAASKLGALNISGSYFDEAIEATEKYRQIDSTNISVNRQN
                     ALAYCLKQDYPTAIRRYEYLVSQGDSSFHTCYYLGISYYAAEKYYEAHDFLEVARKYDP
                     NNINLLYYLGRACSKTSWKKEGVGYLEKAIDLSIPKDSSMTRLYIGMTDCYKMAQMYKE
                     QIASIKKRYQQYDKQNHKLLYDMAYIYFYDLKDKKNAERCLEAFLKTRPKNDKEEAEMN
                     ERGELILGKSNYYNAAANWLKDIQSKQKIEDFFQNSAPQPPLPKKDK"
     CDS             complement(10661..11665)
                     /locus_tag="ctg9_9"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPEEEVETINKYGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAVRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAQ"
     CDS             12099..12353
                     /locus_tag="ctg9_10"
                     /transl_table=11
                     /translation="MKKGLHPESYRPVVFKDMSNGDMFLSRSTVATKETIEFEGETYPL
                     LKIEISNTSHPFYTGKSTLVDTAGRVDKFMSRYGDRKKK"
     CDS             complement(12434..13648)
                     /locus_tag="ctg9_11"
                     /transl_table=11
                     /translation="MINREQYMEQIVPFIDKPFVKVITGIRRSGKSVVLRLIRDELLRR
                     GVREERIIYLNFESFQWIDLKEAKALYAYIRGQAGDAGKYYILLDEIQEVDGWEKVVNS
                     LLVDLDTDIYVTGSNSRMLSSELATYLTGRYVAFHVMTLSFREYLTFHDLQANDPTLNR
                     KEEFQKYLRMGGFPAIHTADYGYEAIYKIVYDIYSSVILRDTVQRHNIRNVELLERVVK
                     FVFDNIGNKLNAKNIADYFKSQQRRVDMNTIYNYLNALESAFIIQRIPRYDIKGKEILQ
                     TNEKYFVSDLSLIYSVMGYRDRLIAGMLENLVCLELKRRGYEVYVGKQDDKEVDFVAIR
                     REEKIYVQVTYQLASQATVEREFAPLLAINDHYPKYVVSMDSLWQDNVEGVRHRHIADF
                     LLDDA"
     CDS             13842..14249
                     /locus_tag="ctg9_12"
                     /transl_table=11
                     /translation="MEITDLKQMTKEEVFNFIRQRLSFSKELQEQFRHVNKDDLAKEHR
                     RFEMSGNESKTGQCTIFNTAILNEFADLSIYDYTSYLFLDFHNGTPTVYLKYFSENENL
                     EYTFTGYTTTEIIFAILELTIFSGKPKRNRS"
     CDS             14982..15413
                     /locus_tag="ctg9_13"
                     /transl_table=11
                     /translation="MPKWISVEKAVIKYHIEKEAILLWVEMGQFPMLYIDNVPNVDEEC
                     ILELFRRSKAGITAEYIDTLEQLCIDKTMVCEKYAHIIQLKEKEIQLQKEINTLINEIQ
                     AAMKRQNERIRDLKKAIGQNNNVIRSDSWIKRLRKRFQW"
ORIGIN
        1 attaattgaa ttacagatgt ttataaagaa agattgttta aattaacatt ctttagtcct
       61 aatatcacca cacagaagaa ggatttgttt cagaccatac attgaaataa gtaggatagt
      121 tgttcaaccc tgtcgggtca taatccgtca atacagaata tttaatcatc tgtccccaac
      181 gcatatacat ataaatactt aaatcaaaat ctttatatgt caaagtattc tggaaaccca
      241 ttgtccaatc cggagagtta tgtcccaata cttgataatc atcagcagac acagaatatg
      301 tattagaagc atcataacgg atttcctgtc cgtcagcatt caccttcgta tagtagacac
      361 taccgtccgt atccgtatgc cgcaccatat caggcacatt aatctttata gatcccggct
      421 tcagtccaaa cacagcagca tcagcttctt cacctttctg ccagatacca tccaatttgt
      481 agtgataaaa agagttgatt gcactaccta ccgcatacgt ataatcgcca ttgattactt
      541 tatcattagc agttccggtc agtttcgtaa tctcttcctt attatatgca aaagtcagag
      601 ccgatgtcca ttgaaaattt ttagtttcaa tgttgcgggt attcaaagca agctcaagac
      661 ctttattttt agtttcacac aagtttatat tggtcagata ttgctcttta gaactatagg
      721 aaccgttcac tacaggtaat gattttttcc atatcacacc ttccgtctta gtcttataca
      781 tatccaatgt tacattgata cgattattca ggaaagaagc atcaataccg atattggtgt
      841 tctttgaacg ttcccatgtc agttccggat tagctattat tttagtgaga ttataaatct
      901 gcgttttttc accacctaat gtcaaccatc cggactccag agaagaagag gaagaataag
      961 gatcaatact ggccgtacca gaaataccgt aacccacacg aatttttaaa ttatccaacc
     1021 agtttcttgt actttccata aacttctcgt cagaaatacg ccatcccaat gaaacagccg
     1081 ggaaattaga ccatttatga tctttagcca aacgtgaaga accatcccga cgaatagaag
     1141 cagaaagcaa atacctaccc aataaagagt agttgatacg tcctactaat ccgactcctt
     1201 tagacatggt ataactggat gaatttttct gaacggcagc tttttccaat ccttcccaca
     1261 aatatttatt gttagcaata cctgttcctg tcatttccgt gttatccgtc tggttatgat
     1321 tccaggtaga cacaccagta agcgtaaatt catgtatctt agcaatatta aagttgtaag
     1381 ttacgatatt ttcccactta taattatatg atctgttttg agtaatcttg gcatttgtat
     1441 ctgtctctac atttcctccc gctttataaa agttgtacga gccatctccc tggaaactat
     1501 tcgaacggga ataagtcaac gtcccattca cgcgtgactc ccatgtcaat cctttaatcg
     1561 gagttatttt aatataagga ttcacataca gttttgtatt ctgggattgg tttctccaat
     1621 tacttttatt attcatcaaa agattcaaat agccggcatc cccttcaatc ggataaggat
     1681 taacattgcc attctcgtca tagatttcac cataaggaat agccgtcata ccatcttgaa
     1741 tctttgcaaa aggcttattc tgatgcacat aagatgcctg aatactaatt cctgtagtaa
     1801 accatttatt gattgtgtga tcgatgcgaa tatttgttga atacaattta taattatcat
     1861 cgttgtattg tccgttttca tcggagaaat tcatagacat ataggccttt gtattttttg
     1921 tacctcctga aaccgacaaa ctataattct gaacagtccc cgtatgcagc aattcatcta
     1981 cccagtcaat gtatttcccg ttttgataag cttcataata agcagggtta gtaaacatat
     2041 tggcatcatc cacataagta cccgcatttt tgtgagctgt acgcaagccc tccatgtagg
     2101 tttctccttg gcggacttcc ggcattgtag accagctgtt tataccaaaa aaagcattaa
     2161 aattagcagt caattttcct tcttttccgc ctttggtagt aatgattaca acaccattgg
     2221 caccggaaga accataaaca gccgtagaag aagcatcttt caacacttca atagattcaa
     2281 tatcattcgg attcagtgtc gcatagtcac ccggcatccc gtcaataata aacataggat
     2341 taccacttgc tgtcaatgaa cggttaccgc gcaattgcat tttcactcct gaacccgctt
     2401 gacccgattc tctcgtaata tccaatcccg ctactttacc ctgcaacgct tccatcgggt
     2461 ttgtgcccgg attcatcgta atgtcttccg atttcactga agcaaccgcc cctgttaaat
     2521 cacgtttctt cactgcaccg tagccaatga ccaccacttc atccaatgcc tgcgtatccg
     2581 aaatcatttt cacattgacc ggtccgttac ccgtcacagt caccgtttgt tctttgtaac
     2641 cgatataaga aatgaccagt tcttttcttc ccgccggaag attgatagag aagttaccgt
     2701 taaaatcggt aatcgtacct gtacttgttc ctttcacaac gatagaaacc ccaatcaacg
     2761 gctccccgct ttcatcaatg atagttcctt tcacagtttt cgtttgtgtg acaacttgca
     2821 ccatagtatt agaaactcca tcttctgcat acacagaata tgacagaggg gcagacaata
     2881 aagacagccc taaaatcatg gaagcgcgtc tatgatgatt cttccatgct tcaacaaatg
     2941 cattacatct cattcgttct aatttaaagt taatattaat tctcgttgtt ttgcaaaaac
     3001 tattcgatta taatcttaat taaagacgaa gctaatttta atacgtactc acttttcata
     3061 ccatatttct cctataaaat acattttctc cattaaatac gcaactatat attatacttt
     3121 acttcaagca gctccaacaa attctttatt ttgttgttga ataaagaata aaaagtgtaa
     3181 atttgtacct agatgccact gaaactaaca acatattatc atgggaagga cattcctgaa
     3241 ttaccaggaa aaaacgcctt ccattccaaa gagttatttc agatttatga agcgactccg
     3301 ggctatactc ctttattaat agtggcaaca gaagacggca gacctatggc acgcctgctt
     3361 gccgccatcc gcaaagcgaa aaagtggctt ccctcctctt tagtaaaaca ttgcgtagta
     3421 tatagcgaag gtgaatttct ggatgagtcg ctttcgacca acaaagaaaa ggcagaagaa
     3481 gtctttggcg atatgctcga acatctcaca caagaagcat cgcgtagctg tgtcctgatt
     3541 gaattccgga acctaaacaa ttcgatgttc ggctatcggg ttttccgtgc caatgattat
     3601 ttccctatca attggttgcg ggtacgcaat tcgctgcaca gtatgaaaaa gacggaagac
     3661 cggttcagcc cgtcacgcat ccgtcagata aaaaaaggac tcaagaatgg agccaaagta
     3721 gaggaagcac atactgtgga agaaatacac gatttctcac ggatgctgca caaggtttat
     3781 tcctcccgca tacgcagata tttccctgcc aacgactttt tccgccacat gaacaatatg
     3841 ttaatcaaag gacaacaggc aaaaatattc gtagtaaaac acaaagagaa aatcattggc
     3901 ggttccgtct gtatctactc gggagatgac gcgtaccttt ggttttccgg aggaatgaga
     3961 aagacatacg cacttcagta tccgggagtg ctggccgttt ggaaggcatt ggaagacgcc
     4021 cgccaacggg gattccgcca catggaattt atggatgtag gacttccgtt ccgcaaacac
     4081 ggttatcgtg atttcgttct ccgattcgga ggaaagcaaa gcagtacccg ccgctggttc
     4141 cgtgtcaatt ggaattggct gaacaaactc ttagtcaaat tttacgtcta aatgtaatct
     4201 caagattaca aaacaactct tcatactcct tccctaccat tttttctgtt taataatcca
     4261 ataattaaat gcagaaatat ttctttatta ggtaagaaat gtctttcttt gtgctgtttt
     4321 atgccatata agcacatgat taaaaccaaa taaaaaaagt atagttatga agatttcaca
     4381 cattgaacat ctgggcattg ctgtaaaaag catcgaagaa gcccttcctt actacgaaaa
     4441 tgtattaggt ctgaagtgtt acaacattga aacagtggaa gatcagaaag taagaactgc
     4501 ttttttaaaa gtaggcgaaa ccaaaattga actgttggag cctacttgcc cggagagtac
     4561 tattgccaaa ttcattgaaa acaaaggtgc aggtgttcac cacgttgcct ttgctgtaga
     4621 agatggcgta gccaatgctt tggcagaagc agaaagcaaa gaaatccgcc ttatcgacaa
     4681 agctccccgc aagggtgctg aaggtttgaa tattgctttc cttcacccga aatcaacttt
     4741 gggcgtgttg acagaactct gcgaacatta atcataaact ctaaaaccaa caagaactca
     4801 tgagtaatca acttgaaaaa attaaagagc ttattgaacg ccgtgccgta gcacgtatcg
     4861 gaggcggtga aaaagcaatt gcgaagcaac atgaaaaagg gaaatacaca gcacgcgagc
     4921 gtctggctat gctgcttgac gagggtagct tcgaagaaat ggacatgttc gttgagcaca
     4981 gatgcacgaa cttcggaatg gagaaaaaac attatccggg agacggtgta gtaaccggct
     5041 gcggtacaat cgaaggacgt ctggtatatg tgttcgcaca ggacttcact gtttctgccg
     5101 gttcactgtc agaaacgatg tcattgaaga tttgtaaaat tatggatcag gccatgaaga
     5161 tgggtgctcc ttgtatcggt atcaacgact cgggtggtgc acgtatccag gaaggtatca
     5221 acgctttggc aggttatgca gaaatcttcc aacgcaacat ccttgcttca ggtgttattc
     5281 cgcagatttc cggtatcttc ggtccttgtg ccggtggtgc tgtttattct ccggctctga
     5341 ccgacttcac gctgatgatg gaaggcactt cttatatgtt cctcaccgga ccgaaagtgg
     5401 tgaagaccgt tacaggtgaa gacgttagtc aggaaaacct cggtggcgca agcgttcact
     5461 ccactaaatc gggtgtaact catttcaccg cccaaacaga agaagaaggt ttcgaactga
     5521 ttcgcaaact gttgagctat attcctcaaa acaacctcga agaagctcct tatgtagatt
     5581 gcacagaccc aatcgaccgt ctggaagatt ctttgaacga tattatcccc gacagcccta
     5641 ctaaaccgta tgacatgtac gaagtgatcg gcgctattgt ggacaacggt gaattccttg
     5701 aaatccagaa agattatgca aagaatatca tcatcggttt cgcccgcttc aacggacaat
     5761 cggtaggtat cgttgctaat cagcctaagt atctggctgg tgtgctcgac agcaatgcat
     5821 ctcgtaaagg cgcacgtttc gttcgtttct gcgatgcatt caatattcct atcgtatcgt
     5881 tggtagacgt accgggattc cttccgggaa caggtcagga atacaatggc gttatccttc
     5941 atggtgctaa actgttgtat gcttacggtg aagctactgt gcctaaggtt actatcacat
     6001 tgcgtaaatc ttacggtggt tctcacatcg taatgagctg taagcaactt cgcggtgaca
     6061 tgaactacgc atggcctact gccgaaatcg cagtaatggg tggtgcagga gcagtagaag
     6121 tattgtacgc acgcgaagcc aaagatcagg aaaaccctgc tcaattcctt gcagagaaag
     6181 aagcagaata cacgaaactg ttcgccaatc cttacaatgc agctaaatat ggctacatcg
     6241 acgatgtaat tgaaccgcgc aacacacgtt tccgtgttat ccgtgctttg cagcagttgc
     6301 agactaagaa attgagtaat ccggctaaga agcatggtaa tattccgttg taatcctact
     6361 tttcacatta aaacaagaac gattatgaac aaaaccaaaa tcggaatatt cctttctttg
     6421 ctgttgctga ttggtctgac ttcttgtgga gagcaaaagt cgaacaataa gctggtgcta
     6481 aacgaaatcc tgataaacaa tcagagtaat tttcaggacg attacggatt gcacagcgca
     6541 tggattgaaa tattcaataa atcattcggt agcgccgacc tggcagcttg cttgctgaaa
     6601 gtaagcagcc aaccgggcga tacagttact tattttatcc cgaaaggtga tatactaacc
     6661 ttagtgaaac cacgccaaca tgcactattc tgggcagatg gcgaacctaa ccgtggtact
     6721 ttccatacca gcttcaagct gaatccggaa acagctaact gggtgggtct gttcgactcc
     6781 ggcaaaaagt tgctcgacca gattgtagtg cctgcaggcg ctctcggtcc caatcaatca
     6841 tacgctcgtg taagcgacgg ggcagctgaa tgggaagtaa aaagtggaag cggtgacaaa
     6901 tacgtgactc cgagcaccaa caacaagact cttgacagca attccaagat ggaaaagttt
     6961 gaagaacacg atgctgatgg cgttggaatg tccatttctg ccatgagcgt agtattctgc
     7021 ggattgattc ttctctttat tgcttttaag attgtaggaa aagtagccgt taatttgagc
     7081 aagcgcaacg ctatgaaatc taaaggcatt gacaagcatg aagctaagga actgtcacag
     7141 gctccgggcg aagtatacgc tgctatttct atggcattac acgaaatgca ggatgaggtg
     7201 cacgacgtag aagaaacggt actgaccatc acccgcgtaa aacgcagcta ctcaccatgg
     7261 agttcgaaga tttacacttt gcgtgaaact cctcccagaa agtaagtcac cttttaaaaa
     7321 gtaaaaacga tgaaagaata taaatataaa atcaacggta actcatataa agtaaccatc
     7381 ggagatattg aagacaacat cgctcatgta gaagtgaacg gtacacacta taaagtagaa
     7441 atggagaaac agccgaagcc tgttgcgaaa cccgtgacag tacgcccgat gcctaatgct
     7501 cctgctgctc ctactcaagt agtgaaaccg accgctccgt ctaccggaaa atcaggagta
     7561 aaatctccgc tgccgggtgt gatcctcgac atcaaagtga atgtaggcga tactgtaaag
     7621 aaaggacaga ccattatcat attggaagcc atgaagatgg aaaacaatat caatgcggat
     7681 aaggacggta agattactgc catcaacgtc aacaagggag actctgttct tgaaggtaat
     7741 gacctcgtaa ttattgaata atatgggaga ctttataaac tttttaggaa ataacctggc
     7801 cgacttctgg acatacacag gctttgccaa tgctacggta gggcatgtag tcatgattct
     7861 cgttggcttg gtattcatct atttggcaat agccaaagag ttcgaaccga tgctgctgat
     7921 tcctatcggt ttcggtatat tgatcggtaa catacctttt aatatggatg ccgggctgaa
     7981 agtcggtatt tatgaagaag gttctgtatt gaatatattg tatcagggag tgacctccgg
     8041 ctggtatccg ccgctcatct ttttgggcat cggtgccatg acggacttct cggcacttat
     8101 ctctaatcca aaattgatgc tgatcggtgc agctgcacaa ttcggtatct tcggtgctta
     8161 tatgatcgcg ttagaaatgg gcttcgaccc gatgcaagcc ggtgctatcg gtatcattgg
     8221 tggagcagac ggcccgacgg ccatcttcct ttcttccaag ctagcaccta acctgatggg
     8281 agccattgcg gtgtccgcct actcctatat ggcgttggtt ccggtgatac agccgcctat
     8341 catgcgtctg ctcaccacca agaacgaacg tgtcatccgc atgaaaccgc cacgtgccgt
     8401 ttctcacacg gagaaggtga ttttcccgat catcggtttg ttgctgactt gtttcctggt
     8461 tccttccggt ctgcctttgc tgggtatgct gttcttcggt aacctgttga aagaaagtgg
     8521 tgtaacccgc cgtttggcta atactgccag tggtccgttg attgatacaa tcactatcct
     8581 gttgggtctg acagtaggtg cttctacaca agcatccgaa ttcctgacgc ttgactctat
     8641 caagatcttt gccctcggtg cattgtcatt tgttattgca acggcatctg gtgtcatctt
     8701 cgttaagatc ttcaatatct tcctgaagaa gggtaataag atcaatccgt tgatcggtaa
     8761 tgcaggtgtt tctgctgttc ccgactctgc acgtatctcg caagtgattg gtttggaata
     8821 cgattcgacc aactatttgc tgatgcacgc tatgggtccg aacgttgccg gagtgatcgg
     8881 ttcagctgtt gctgccggta tcctgcttgg attcttgatg taagatataa ggcaagaggg
     8941 gacgcttatt tgaacagttc ttaaaacaaa aaataagatt atcctaaaag ccttgaattt
     9001 ataaaatcac ctttactgca tcattgtagt aaaggtgatt ttttattgta agaacttgcc
     9061 gcctaaaaaa tattgcattt gctatggcgt atacatcgta tcgcgttccg ttgtgttatc
     9121 ttctcttatc atttcgttaa tctatctaaa acaacctacg aacaattcgt aattataata
     9181 tttttagtaa cttgcaacag ataagtcaaa caactaaaat aaaatattat gaaacggatt
     9241 atcattctat tctttctttg ctctactatt cctttaatag cgcaacatac agaccctatt
     9301 caagaagcca tggcaaatta tgattatgag actgcccttt ccctcattgc ccaaaagaaa
     9361 tccacccctc ccctgctatt gcagaaaggc aaagcattgc gcggactagg gctcaccaca
     9421 gaggcacttg ccacctatca ggaaattatc cgtaatgata ccacaaatac tcgtgctttc
     9481 atcgaagcag ccgaatgttg ccggacatta gctaactata atcaagccct gaaatattat
     9541 gaacatgcac tcgatctgaa tccggaaaac aaatatgcac gtattcaata tatcagttta
     9601 cttctatccc agcagaagtt tagggaggcg cttggtgaaa gcagcctgat gacggaaaaa
     9661 gacagttccg ccattgccct gcatttacag gcacaaagct ttgaagggat gggcgaactt
     9721 cttcccgccg caggttgcta ttacaatatc caggctaaat atcccgacga ttatctggca
     9781 gccagcaaac taggcgctct aaatatatcc ggttcttatt ttgacgaagc catcgaagct
     9841 acggaaaaat accggcaaat tgacagtacc aacatttccg tcaaccggca gaacgcttta
     9901 gcgtactgct tgaaacaaga ctaccccact gccatccggc gttatgaata tcttgtcagt
     9961 caaggggaca gttcttttca tacttgttat tatttaggca ttagttacta tgcagcagag
    10021 aagtattatg aggctcatga ttttttggaa gtcgcccgga aatatgatcc caacaatatc
    10081 aatctccttt attacctcgg tcgtgcgtgt tccaaaactt cctggaaaaa agagggcgta
    10141 ggctatttgg aaaaagccat tgatctatcc attcccaaag acagcagtat gacccggctc
    10201 tatatcggga tgaccgactg ttacaagatg gcacaaatgt acaaagaaca gattgcatcc
    10261 atcaaaaaac gctatcaaca gtatgacaaa caaaaccaca aattattata tgacatggcc
    10321 tacatatact tctatgactt gaaagacaaa aaaaatgcgg aacgctgcct ggaagcgttc
    10381 ctaaaaacac gtcccaaaaa cgataaagaa gaagcggaaa tgaacgagag aggcgaactc
    10441 attctaggaa aatccaatta ttacaatgct gccgccaact ggttgaaaga tattcaaagt
    10501 aaacaaaaaa tagaagactt ctttcaaaat tccgctcccc aaccccctct cccaaagaaa
    10561 gataaatagg gatagaactg taaagagaca aaaaaggctg ctaccagtgt tcaaaccgga
    10621 gcagcctctt tcttttattt atggaataat ccggagatta ttactgtgcc aatttattgt
    10681 cagaaccgag cacgttgatg attttgtgct tgtacagttt ttccatgttg tcacgagccg
    10741 ggccaagata cttacgtggg tcgaattcag ccggtttttc agcgaatacc ttacgtacag
    10801 cagcagtcat agccagacga gagtcagagt cgatgttgat tttgcaaaca gcagacttag
    10861 cagctttacg caattcttct tccggaatgc cgatagcagc tttcagtgca ccaccatatt
    10921 tgttgatagt ttccacttct tcttccggaa ctgaagatga tccgtgaaga acgataggga
    10981 atcccggaag tttttccatt acagcgtcca atacttcgaa agccaatgga ggaggaacca
    11041 tacggccagt cttcgggtcg atgtggcatt gttccggagt aaatttgtaa gcaccgtgag
    11101 aagtaccgat tgagatagcc aaagagtcgc aaccagtgcg agtagcgaag tcgattactt
    11161 cttcagggtc agtatatgtg tgatggtcgg aagaaacttc atcttctaca ccagccaata
    11221 cgccaagttc accttctaca gttacgtcaa actggtgagc gtattcaaca actttcttag
    11281 tcaatgctac gttttcttcg taaggaagat gagaaccgtc aatcatcact gaagagaaac
    11341 ctgaatcgat acaagatttg caagtttcga atgtatctcc gtggtcaaga tgaagaacga
    11401 tttccggatg tgcgcagcct aattctttag catattctac agcaccctgt gccatgtaac
    11461 gcaacaaagt agcgttagca tactgacgag cacctttaga aacctgaaga atcacaggag
    11521 atttagtttc aacagcagcc ttgatgatag cctgcatttg ttccatattg ttgaagttga
    11581 atgctgggat agcatatcca cctttgatag ccttagcaaa catttctctt gtgtttacca
    11641 atcctaaatc tttgtaattt accattttgt ttaaagttta ttgttagtga ataaaaattc
    11701 tacgcaaaag taagcattat ccatcgaata acgaacatcg gaaagaaaaa tatagtagaa
    11761 aaaggtttaa atcagactgc aaaatttagc aggaatacga gtgtgacatt agattgtaat
    11821 gtctaccttg caaactttgg gatttatgat ttctgaattc tgatttatgc cttcggattt
    11881 atatctcctt atttatacct tatttatacc tcatttttca ttcatttaat caccaaaatc
    11941 tgcatagcaa atcagaaatc ataaattaga aatcagaaat tttagaaaac ctttttctat
    12001 ttcacagaaa agcattatct ttgcgctctg aaaatgacca ttacactatt tcttaccaaa
    12061 atagtaacag aatataaatt aaaaaaacag atactgaaat gaaaaaaggc cttcatccag
    12121 aatcataccg tccggtagta tttaaagata tgtcaaatgg tgacatgttt ttgtctagat
    12181 caactgtagc aactaaagaa accatcgaat tcgaaggtga aacttatccg ttgctgaaga
    12241 ttgaaatctc aaacacttct cacccgttct atacaggtaa atctacattg gtagatactg
    12301 caggtcgtgt tgacaagttc atgagccgtt acggtgaccg taagaagaaa taattcgatc
    12361 tttcgtgaaa gatgaaaaaa gaggagattc tcgcagagaa tttcctcttt ttcgttttct
    12421 atattcctta acgtcaagca tcatccaaca agaaatcggc tatatgacga tgcctgaccc
    12481 cctccacatt atcctgccac aagctgtcca tactaactac atatttagga taatggtcgt
    12541 taatggcgag caaaggagca aactccctct caacagtggc ctgtgaagct aactgatacg
    12601 ttacttgcac ataaatcttt tcttcccgac ggatggctac aaaatccact tctttatcat
    12661 cctgtttgcc tacatacact tcataacccc ttcttttcaa ctccagacag accagattct
    12721 ccaacatacc tgcaatcaac cggtcacgat agcccatcac ggaataaatc aaagaaaggt
    12781 cacttacaaa atacttttca ttcgtctgca gaatttcctt tcctttaata tcataccggg
    12841 gaatacgttg aatgataaaa gcactttcca atgcattcag ataattatag atggtattca
    12901 tatccaccct ccgttgctga cttttgaagt aatcagctat atttttagcg ttcagcttat
    12961 tgcctatatt atcgaaaaca aacttcacta cccgttcgag cagttccaca ttccggatat
    13021 tgtgacgctg caccgtgtca cgaagaatga cagaagaata gatgtcgtag acaattttat
    13081 agatagcctc atatccataa tcggcagtat gtatggccgg aaatcctccc atacggagat
    13141 atttctgaaa ttcctccttc cggttgagtg tcggatcatt ggcctgcaag tcatggaaag
    13201 tcagatattc tctaaaagac aaggtcatga catggaaagc gacataccgt cccgttaaat
    13261 aagttgccag ttcggacgat aacatacgtg agttggagcc ggtcacataa atatccgtat
    13321 ccaaatctac cagaagtgag ttgaccactt tttcccaacc gtccacttcc tgaatttcat
    13381 ccaagagaat ataatattta cccgcatctc ccgcctgtcc ccgaatataa gcatacaaag
    13441 ccttcgcctc tttcagatct atccactgaa aactttcaaa attcagatag atgatacgtt
    13501 cttcacgaac tcccctcctc aacagttcgt cacgaatcag acgcagcact accgactttc
    13561 cactgcgacg aatacccgtt atcactttta caaacggctt atctataaaa ggaacaattt
    13621 gttccatata ctgttcacga ttaatcatat tcaaaagttt ttagggttat aagcacaaag
    13681 atatactatt ttcggaaagt ttttagggtt ataaccctaa ataaatccat aaattcagat
    13741 tcttttaggg ttataagccg aaaaataaat aaaagaaata tgactaaatc cgatttatta
    13801 ccaaataaag aaagtacctt taccccaata attaataaaa aatggaaata accgatttaa
    13861 aacaaatgac aaaggaagaa gtttttaatt tcatcagaca acgcctttct ttcagtaaag
    13921 aactgcaaga acaattcagg catgtgaata aagacgatct cgcaaaagaa catcgcagat
    13981 tcgaaatgtc cggaaatgaa tcaaagacag gccaatgcac gattttcaac acagcgattc
    14041 tgaacgagtt tgccgatctt agcatctatg attatacttc ttaccttttt ctcgacttcc
    14101 acaatggcac tccaaccgtt tatctcaaat acttctccga aaatgaaaat ttggaatata
    14161 catttaccgg atataccaca acggaaatca tctttgcaat tcttgaacta actatcttct
    14221 ccggaaagcc caaaagaaat cgcagctaaa aaaagaattg cacggaaaga caatacgagg
    14281 tcagaagact tttatggctt tcatttaggc acggattaca cagatttcac ggttttagtc
    14341 taatggaacc gcgaaatccg tataatccgt acctaaataa tatcaatcta atagatggtt
    14401 ttactttgga ctccctcctt tttatcattg cattatattt gccacccgta tagcatattt
    14461 accatcttta taccatattc tctattctca taccatattt cctgcattta tttcctcttt
    14521 tccatcctat tccgaaaaaa acatatatct ttgtcatacg ctttctgccc atcagcgtga
    14581 tgaaacaggc aaaagcggtt tttattcctt catggagtaa ataacgtatt gtctctcaaa
    14641 cttgaaaatt agcagttctt tgtagagaga gatgatacag cagatactcc acgtagatgg
    14701 tcgtatatca acatatcgat tagagatgtg ttatatataa acgtttggcg tgggtgtctg
    14761 ttgttatcat tgtcttctac aagggtgttg ctaagcctca agtttagata atggtacaac
    14821 agcactcacg cttttattgt atccggtcgg tttcaacaat ccttataccc caaccaattc
    14881 cccagccgac cgaaatcata aaaatcgtgg gtgttcgttg cacctctccg gacaatacgt
    14941 tatttactct tttttttata acacattaaa acaaaagcaa tatgccaaaa tggattagtg
    15001 tagaaaaagc agtgattaag tatcacatcg aaaaagaagc gatcctgctt tgggtggaaa
    15061 tgggacaatt ccctatgtta tacatagaca atgttccgaa cgttgacgaa gaatgtattc
    15121 tggaactctt tcgccgaagt aaagccggca ttacagcaga atatattgat acgctggaac
    15181 aactgtgtat agacaaaacg atggtctgcg agaaatacgc ccacattatt caattgaaag
    15241 aaaaggaaat tcagctgcag aaggaaataa atacgttgat aaacgaaata caggcagcaa
    15301 tgaagagaca aaacgaacga atccgggatt tgaaaaaagc gattggacag aataataatg
    15361 ttatacgtag cgacagttgg ataaaaaggc tgcgcaaaag gtttcaatgg tgaataatta
    15421 tcagcgtacc aattaccatg tgggacacaa cgtaaacaat tagcatattg gcacattatt
    15481 gcacggtttt taccacagag gacacagagg acacagaggt gaatttgttt tatgacttac
    15541 ggttgtgacc ctaattttga tgcgtaatcc tcttctataa agttgaaaaa aggttcttcg
    15601 tcaaatttgg tggtaatctc ttttttattt caccggtctt cttctttctt aatcctatta
    15661 aaagttgt
//
