GCA_015550625.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaDIMEDOCC_2 (original name was: gnl|Prokka|DIMEDOCC_2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	HR-T2PKS	1	31,542

gnlProkkaDIMEDOCC_9 (original name was: gnl|Prokka|DIMEDOCC_9)

Region	Type	From	To	Most similar known cluster		Similarity
Region 9.1	ranthipeptide	92,523	114,130
Region 9.2	RRE-containing	214,989	235,252

gnlProkkaDIMEDOCC_14 (original name was: gnl|Prokka|DIMEDOCC_14)

Region	Type	From	To	Most similar known cluster		Similarity
Region 14.1	NRPS	38,427	78,729	leucomycin	Polyketide	3%

Region	Type	From	To	Most similar known cluster	Similarity
Region 2.1	HR-T2PKS	1	31,542
Region 9.1	ranthipeptide	92,523	114,130
Region 9.2	RRE-containing	214,989	235,252
Region 14.1	NRPS	38,427	78,729	leucomycin	Polyketide	3%

No secondary metabolite regions were found in these records:: gnlProkkaDIMEDOCC_1 (original name was: gnl|Prokka|DIMEDOCC_1); gnlProkkaDIMEDOCC_3 (original name was: gnl|Prokka|DIMEDOCC_3); gnlProkkaDIMEDOCC_4 (original name was: gnl|Prokka|DIMEDOCC_4); gnlProkkaDIMEDOCC_5 (original name was: gnl|Prokka|DIMEDOCC_5); gnlProkkaDIMEDOCC_6 (original name was: gnl|Prokka|DIMEDOCC_6); gnlProkkaDIMEDOCC_7 (original name was: gnl|Prokka|DIMEDOCC_7); gnlProkkaDIMEDOCC_8 (original name was: gnl|Prokka|DIMEDOCC_8); gnlProkkaDIMEDOCC_10 (original name was: gnl|Prokka|DIMEDOCC_10); gnlProkkaDIMEDOCC_11 (original name was: gnl|Prokka|DIMEDOCC_11); gnlProkkaDIMEDOCC_12 (original name was: gnl|Prokka|DIMEDOCC_12); gnlProkkaDIMEDOCC_13 (original name was: gnl|Prokka|DIMEDOCC_13); gnlProkkaDIMEDOCC_15 (original name was: gnl|Prokka|DIMEDOCC_15); gnlProkkaDIMEDOCC_16 (original name was: gnl|Prokka|DIMEDOCC_16)

Compact view

gnlProkkaDIMEDOCC_2 - Region 1 - HR-T2PKS

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Location: 1 - 31,542 nt. (total: 31,542 nt) Show pHMM detection rules used

Region on contig edge.

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene overview

NRPS/PKS domains

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

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Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaDIMEDOCC_9 - Region 1 - ranthipeptide

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Location: 92,523 - 114,130 nt. (total: 21,608 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaDIMEDOCC_9 - Region 2 - RRE-containing

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Location: 214,989 - 235,252 nt. (total: 20,264 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaDIMEDOCC_14 - Region 1 - NRPS

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Location: 38,427 - 78,729 nt. (total: 40,303 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 38426 - 78729:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg14_61

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AMP-binding (457..845): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASFLGGVYK
Nearest Stachelhaus code(s):: Ile DALFMGGVYK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1479..1869): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMKNLGTVSK
Nearest Stachelhaus code(s):: Asp DMKDLGMVDK (53% 8Å match)
Stachelhaus code match:: 70% (weak)