LOCUS       gnlProkkaBJLCDPEL_455  13545 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BJLCDPEL_455.
ACCESSION   gnlProkkaBJLCDPEL_455
VERSION     gnlProkkaBJLCDPEL_455
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 06:24:54
            Original ID  :: gnl|Prokka|BJLCDPEL_455
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13545
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13545
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1956:3545]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1957..3545
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13545
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13545
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             2..1483
                     /locus_tag="ctg455_1"
                     /transl_table=11
                     /translation="MNKLKGTGIFAAAALTAALIAGNNIPGVTRQVSAAESQENTVSSL
                     IPDNITLDKPVELANVELPATEYGTFEWVDGSFVPAQRVQSCEVLLIPAEGQDLSHVDG
                     WDPESGAVVGYINVIVNSITDSDNVDKTEGSGKTDPTENADPTETPETSSEKPAADENA
                     DTDNKEDKESKSDQDNKTDTDNEENKIEEDKTDNKNNKDNNSNADKTDKDTETTGKLEP
                     ADDMTQDKEDTKKDDEDGAGDNIFDNPVLPDDKDDRPTDAEDSLSDEEKEERAALNHTC
                     DGITVSGVNLPWYVQFRVSSGDSYQFTNESDAMIFQSYEFELWDLKNNTEYEIPNGDYI
                     SVTVPVKSGYQYTIEHLLDNGATETIIPSVENGIMVFSTHSFSPFGIAGSRQLVGPDAG
                     NDTDDTDAVTPAPASSDSQSSDSGKNNTVSVNDSSDSNNGSSSDQNDNSTENKAVKNNN
                     TVNTGDTTSIMPFVILFVAAAVIAGVAVFIKKRKK"
     CDS             1533..1883
                     /locus_tag="ctg455_2"
                     /transl_table=11
                     /translation="MKVRAILKSLLFAYALTGVALLLLALVLFAFDLGETAVDAGIIII
                     YVLACFMGGFMAGKIVRKDKYLWGVITGLAYYVLLLTVSVMAKGGWDMSAAHAVTTFFM
                     CTGGGTLGGMLS"
     CDS             1957..2097
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg455_3"
                     /sec_met_domain="TIGR03973 (E-value: 3.3e-28, bitscore:
                     87.3, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 4.2e-28, bitscore: 87.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQ
                     K"
     CDS             2178..3545
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg455_4"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.6e-29,
                     bitscore: 92.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.1e-16, bitscore: 51.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 9.5e-15, bitscore: 45.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.4e-20, bitscore:
                     62.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEA
                     IAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIA
                     HDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNW
                     QVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHD
                     YMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQI
                     SVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCV
                     YKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYT
                     KKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD"
     CDS             3657..6065
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:MMPL domain-containing transport protein (Score:
                     37.5; E-value: 1.3e-11)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg455_5"
                     /transl_table=11
                     /translation="MKKSKGIVVLLLTLILTVFFCFTAAVGIGPTGTGAAKHINTGLDL
                     AGGVSITYQAKESNPTSEEMSDTIYKLQKRVEQYSTEAQVYQEGSDRITVEIPGVTDAD
                     TILNDLGKPGSLYFITKEDADGNQNFTTGQDGYVLSRTMNEIKESGSVVLEGSDVADAQ
                     GGAIQNQNTSAKEYVVSLTLTSDGENSGKTKFAEATKNNVGKQIAIVYDNNIISAPNVN
                     EEISGGKAQISGMSDLEEAQNLASYIRIGSLGLELEELRSSVVAAQLGEEAISTSVLAG
                     AIGLIIVIIFMIIAYRIPGVVAGIALILYTSLMLITLNAFDITLTLPGIAGIILGIGMA
                     VDANVIIYARIREEIGAGVSVRNSIKSGFSKAFSAIFDGNITTLIAAFVLMWLGSGTVK
                     GFAYTLALGIVISMFTALVVSRLIVNALYAVGVRDPKFYGSAKERKAVDFLGKKKVFFA
                     ISIILILCGPAAMFANSHAGNKALNYSLEFSGGTSTTVTFNEDMDIKTIDSEVTPVVEE
                     VTGDKNVQPTKVVGTNQVVIKTRSLNQSEREALQSALVEKFGVDDSTISTESISSTVSS
                     EMRRDAIVAVIVATICMLLYIWFRFKDIRFASSAVLALLHDVLVVLAFYAIARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLHSGSREKLAEIVNTSITQTLTRSIYTSFTTFV
                     MVAVLYIMGVSSIREFAAPLMVGVLVGAYSSVCITGALWYVMKKKFAGKGQPAIVAASA
                     SAKSSSKPKKARDVSQKDPTQPKKKNRKRVAERLAAEEAAKKQQNDDAE"
     CDS             6147..7859
                     /locus_tag="ctg455_6"
                     /transl_table=11
                     /translation="MEKWVIAAKRADFNQIGQQFHIDPVIARLIRNRDVIGEDKIREYL
                     SGTVQELPSPWLMKDMEKAVDILEKKISQKAKVRIIGDYDIDGVTSTYILMKGLARIGA
                     DVDTYIPDRVADGYGIHAHLIERAETDRIDTIVTCDNGIAAAAEIQMAKDKGMTVIITD
                     HHEVPYREEKGERQMVLPPADAILNPKQYDCPYPNKNLCGAVVAFKYIAALYERFGVPA
                     EELEDYYELAAIATVGDVMDLQGENRILVKEGLCRLKNTKNQGLQELIRANSLEDAKIT
                     AYHIGFVLGPCINASGRLDTAARSLALLNAKTKEEAARLAGDLTALNQSRKALTEKGKE
                     EAIRIIETTELKNDRVLVVYLPDCHESLAGIIAGRIREKYHRPAFVLTGGEASAKGSGR
                     SIESYSMYEELVKCADLMIQFGGHPMAAGLSIEEKNIEEFRRRLNVNCTLTDEELRPKI
                     VIDVPMPVSYITKELVEQISLLEPFGKGNTKPVFAQKNLRVLDYSIIGKNKNVVKLKLL
                     DPQGISVEGIYFGEAEDFVNFIREKDSISVTYYPEINRFRGRESLQIIIQNYC"
     CDS             8007..8531
                     /locus_tag="ctg455_7"
                     /transl_table=11
                     /translation="MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCL
                     KDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEM
                     HKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGY
                     DVASVICYDGK"
     CDS             8569..10899
                     /locus_tag="ctg455_8"
                     /transl_table=11
                     /translation="MTEITKSTEAKKDEMQVEKEKLESVKRADAAVKTMHDFTSPEVLY
                     KELINSVLKYHPSTDISMIEKAYKVASEAHEGQKRKSGEPYIIHPLCVAIILADLELDK
                     ETIVAGLLHDAVEDTWMTYEEVEKEFGSEVALLVDGVTKLGQLSYSADKVEVQAENLRK
                     MFLAMAKDIRVILIKLADRLHNMRTLQYMRPEKQQEKARETMDIYAPIAMRLGISKIKV
                     ELDDLSLKYLKPDVYYDLVHKVALRKSEREQFVGAIVKEVKKHMDDANIKAQVDGRVKH
                     FFSIYKKMVNQDKTIDQIYDLFAVRILVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMP
                     KPNMYQSLHTTLIGPNGQPFEIQIRTYEMHRTAEYGIAAHWKYKESSDGKAPVGKSEEE
                     KLNWLRQILEWQRDMSDNKEFMSLLKNDLDLFADSVYCFTPQGDVKTLPSGSTPVDFAY
                     SVHSAVGNKMVGARVNGKLVPIEYEIKNGDRIEIITSQNSQGPSRDWLKLVKSTQAKNK
                     INQWFKKELKEDNILKGKEMLAQYARAKGFKIANYTKTQYLEAVLRKYGFRDWDSVLAA
                     IGHGGLKEGQVFNKLVEAYDKENKKNLTDEQVLEAASETQEKLHIAKSKSGIVVKGIHD
                     VAVRFSKCCNPIPGDEIVGFVTRGRGITIHRTDCVNVLNMSETDRTRLIEAEWQQPDTK
                     EKEKYMAEIQVYANNRTGLLVDLSKIFTERKIDLRSINSRTSKQEKATISMSFEIGSKE
                     ELRSLIEKIRQVESVIDVERTTG"
     CDS             10964..11593
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     163.1; E-value: 9.6e-50)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg455_9"
                     /transl_table=11
                     /translation="MKNLELQKCILGPVYTNCYLLKNKETGELIIVDPADCPEKIEMKI
                     SRMNGKPVAILLTHGHFDHILAAQAVKEKYNIPIYACRQEEEMLREPSINMTVHYGQGC
                     SIVPDVFLEDLDVIRLAGFSVQMIHTPGHTKGSCCYYLKDEGVLFSGDTVFYGSVGRTD
                     FPGGSTAEIVRSLHKLVDSLPEETEVFPGHDASTTIGYEKRYNPFV"
     CDS             11586..13100
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg455_10"
                     /sec_met_domain="PF04055 (E-value: 5.7e-25, bitscore: 78.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCKIGILFKNRDFEHDVYELIKAFYPEAEIHTLYENGEAEYDLRF
                     SVERDNDSYIIKYERTENLSKQETEQKGVISADILSKENAGCGIQDAHALRKENKDNIK
                     YALYQLLVKLTGRTLPWGNLTGIRPAKLAMGMIESGMKNTEAAREMRERYLVSPQKTAL
                     AITIANREREILKDIDYENGYSLYIGIPFCPSICLYCSFSSYPLKVWEKRTDEYVEALC
                     REVRETALMMKGRKLDTIYIGGGTPTTLLPHQIRKLLDTVGEAFGYEGLAEFTVEAGRP
                     DSITREKLMAIREYPVTRISVNPQTMNQETLDIIGRRHTVEQTKEAFHLARELGYDNIN
                     MDLIVGLPGEDIHMVERTLEQVRELAPDSITVHSLAVKRAARLNIFKEKYQEMSFENNQ
                     EIMDLTMKTAYEMGMGPYYLYRQKNMKGNFENVGYAKVDKAGIYNILIMEEKQPIIALG
                     AGGSSKLVFDHGQRIERVENVKDVSNYISRIDEMIERKRTAIATWL"
ORIGIN
        1 aaaaaataaa ttaaaaggaa cgggtatttt tgcggcagcg gctttaacag cggctttgat
       61 tgcaggaaat aatataccgg gtgtaacaag acaggtcagc gcggctgagt cacaggagaa
      121 tactgtgtct tctctgatcc cggacaacat tacgcttgat aagcctgtag aacttgcgaa
      181 tgtagaactt ccggcaacgg aatatggaac ttttgaatgg gtagatggaa gtttcgttcc
      241 tgcacagcgt gtacagagct gtgaggtact tcttataccg gcagaagggc aggatttaag
      301 ccatgtggat ggatgggatc cggagagcgg cgcggttgtc ggttacatca atgtaatagt
      361 gaacagtatt acggatagtg ataatgttga taagacagaa ggctcaggta aaacagatcc
      421 aacagaaaat gcagatccga cagaaacgcc tgaaacttcg tcagaaaaac ctgccgcaga
      481 tgaaaacgct gatacagaca ataaagaaga taaggaaagt aaatcagatc aggataataa
      541 aactgataca gacaatgaag agaataagat tgaagaagat aaaacagata ataaaaacaa
      601 caaagataat aacagcaatg cagataagac ggataaagat acagaaacta ccggtaagct
      661 ggaacctgca gatgatatga cacaggataa agaagatacg aagaaagatg atgaagatgg
      721 cgcaggtgat aatatctttg ataatcctgt tctgccggac gataaggatg accgtcctac
      781 agatgcagag gattctcttt ctgatgaaga aaaagaagag agggccgcac ttaatcatac
      841 ctgcgacggt attacagtaa gcggagttaa tcttccatgg tatgtacagt tcagagtttc
      901 aagcggtgac agttatcagt ttaccaatga atcagatgca atgattttcc agtcttatga
      961 atttgaactc tgggatctta agaataatac agaatatgag atccctaatg gagattatat
     1021 cagtgtcact gtgccggtaa aatccggata tcagtatact atcgaacatc tcctggataa
     1081 cggggcaact gagacgatta ttccgagtgt agagaatggt attatggtat tcagcacaca
     1141 ttctttcagt ccatttggaa ttgcaggaag cagacaatta gtaggacctg atgcggggaa
     1201 tgatacggac gacacagatg cggtaactcc tgcaccggct tcctccgaca gtcagagctc
     1261 tgattccgga aagaacaata cagtatctgt gaatgacagt tctgacagca ataatggttc
     1321 ttcttctgat cagaatgata attcaacgga aaataaagct gtgaaaaata acaatacagt
     1381 aaataccgga gatacaacat caattatgcc gtttgtgata ctgtttgtgg cagctgcagt
     1441 gatcgccggt gtggctgtat ttataaaaaa gagaaagaaa taaaagaata acactgattc
     1501 ctcccccata tagtttaaca ggaggggaag caatgaaagt cagagcaatt ttgaaatcac
     1561 tattatttgc atatgcatta acaggagtgg cattactgct tttggccctg gtactgtttg
     1621 cttttgatct gggagaaaca gctgtagatg cggggattat tataatttat gtacttgcat
     1681 gtttcatggg aggctttatg gccggcaaaa ttgtgcgtaa agacaaatat ctgtggggtg
     1741 ttatcacagg cctggcttac tatgtattac tgttgactgt ctctgttatg gcaaaaggcg
     1801 gctgggatat gagtgcagct catgcagtta caacattttt tatgtgcaca ggcggtggaa
     1861 cactgggtgg aatgctgtcg taaaaaaaag cttttaaaat gaaaagatat atgatatact
     1921 atgccaagaa tataattaca taaggaggat agagttatgg aacatatcaa aaccctgaat
     1981 acaaagaatt tacagaacac tgtaaaaaaa ggtggatgtg gcgagtgcca gacttcctgc
     2041 cagtccgcat gtaaaacttc ctgtacagta ggaaaccaga gctgcgagca gaaataagat
     2101 cagctatgga gaaatgagat aagcagcgga acttttattc cgctgcttat cttacgctta
     2161 gaaaggattt tagtaaaatg agtctgattc accgttataa aagcaatggc tttaatattg
     2221 tactggatat caacagtgga tgcatccatc tggtagatga ggttacatat gaggttcttc
     2281 catatctgga agagggcctt ggcacagaag ctattgcaga gaaactggaa aacaaatata
     2341 acagagaaga tattgagaca tctgtaagag aatgtaataa gctgaaagaa gatggaatgc
     2401 tttttacaaa agatgtttat gagaatgtaa ttgaagaatt ttcaaataac cggcagaccg
     2461 ttgtaaaagc attgtgcctg cacattgctc atgactgcaa tctggcctgc cgttattgtt
     2521 ttgccgaaga aggcgaatat catggcagaa gagctcttat gtcctatgaa gtcggcaaaa
     2581 aagctcttga tttcctgatc gcgaactccg gttccaggaa aaacctggaa gtagatttct
     2641 ttggcggcga gccgctgatg aactggcagg ttgtaaaaga tctggtaaaa tatggcagag
     2701 agcaggaaaa gcttcacaat aagaaattcc gtttcacttt aacgacaaac ggagttcttc
     2761 tgaatgatga agtaatggaa ttctgcaata aagagatggg caacgttgta ctgagtgtgg
     2821 acggacgtaa ggaagtacat gattacatgc gtccattcag aaaaggtgca ggaagctatg
     2881 acctgatcat gccgaagttc cagaagtttg cagaatccag aaatcaggac aagtattatg
     2941 taagaggtac ttttacccac cataatcttg atttctccaa ggatgtgctt catctggcag
     3001 atcttggatt caaacagatt tctgtagagc ctgtagttgc ggctgatacg gaggaatatg
     3061 caatccgcga ggaggatatc ccccagatca tggaagagta tgatactctt gcaaaagaaa
     3121 tgattaaaag agagaaagag ggaaaaggat ttaacttctt ccattttatg atcgacctta
     3181 caggtggccc ttgtgtatac aagagactgt caggctgcgg ttcaggaaca gagtacctgg
     3241 ctgtaacacc ctggggtgat ttttacccat gtcaccagtt tgttggtgaa gaacagtatc
     3301 tcatgggaaa tgtagacgaa ggcatcacaa agccggaaat ccagaaggaa ttcggcggat
     3361 gcaacgttta cacaaagaaa gactgcaaag actgcttcgc acgtttctac tgtagtggcg
     3421 gatgtgcggc aaatgcattc catttccagg gagatatcaa aggcaattat gaaatcggat
     3481 gcgaactcca gagaaaacgt gtggagtgcg ccatcatgat aaaagccgca ctggcatgtg
     3541 attagtgggc agtaatctgt ctgactgata ccgccgtcgg ctgttatcat aacagaaaat
     3601 ggctggcagg cggatgaaca tgaccgcgga caaaaaatca agaagggaaa agaactatga
     3661 agaaaagtaa aggaatcgta gtgctgcttc tgacactgat cctgactgtg ttcttttgct
     3721 ttactgcagc cgtaggtatc ggtcctaccg gaaccggtgc agcaaaacat atcaacacgg
     3781 gtcttgatct tgccggtggt gtcagcatta cctaccaggc taaggaaagc aatccgacaa
     3841 gcgaagagat gtcagatacg atctacaagc ttcagaagcg tgtagagcag tacagtactg
     3901 aggctcaggt ataccaggaa ggatcagacc gtattacagt tgaaattcct ggtgttacag
     3961 atgcagatac tattctgaat gatctgggta aaccaggttc cctgtatttc atcacaaaag
     4021 aagatgctga cggaaaccag aactttacta caggacagga tggatatgtt ctttccagaa
     4081 ctatgaatga gatcaaggaa tccggaagtg ttgttctgga aggttctgat gtagcagatg
     4141 cccagggtgg tgcgatccag aatcagaaca caagtgcaaa ggaatatgtg gtaagtctta
     4201 ctcttacttc tgatggagaa aacagtggta aaacaaaatt tgcagaagct acaaagaata
     4261 atgtaggcaa gcagatcgct atcgtctatg acaataacat tatcagtgct ccgaatgtaa
     4321 atgaagagat ttccggcgga aaagcacaga tcagcggaat gtctgacctg gaagaagcac
     4381 agaaccttgc ttcttatatc cgtatcggtt ctctgggact ggaactggaa gaacttcgtt
     4441 ccagtgttgt agctgcacag cttggtgaag aagcaatctc tacaagtgtt cttgcaggtg
     4501 cgatcggtct gattatcgtt attatcttta tgatcattgc ataccgcata cctggtgtag
     4561 ttgcaggtat tgcactgatt ctttatacat cattaatgct gatcacgctg aatgcctttg
     4621 atattactct tactcttccg ggtattgcgg gtattatcct tggtatcggt atggcggtgg
     4681 atgccaatgt tattatttat gcccgaatca gagaggaaat tggtgcagga gtttcagtaa
     4741 ggaattctat taagtccggt ttcagcaaag ctttctctgc aatctttgat ggaaatatta
     4801 caacactgat cgcagccttt gtgctgatgt ggcttggttc aggtactgtt aagggatttg
     4861 cttatacact tgcccttggt atcgtgatct ccatgtttac agcactggtt gtatccagac
     4921 tgattgtaaa tgcactttat gcagttggtg tacgtgatcc gaaattctac ggatctgcaa
     4981 aagaacgtaa ggcagttgat ttccttggaa agaagaaagt attttttgct atttccatta
     5041 tcctgatcct ctgcggtccg gcagcaatgt ttgctaattc gcatgcagga aacaaagcgt
     5101 taaattacag ccttgagttc tcaggcggta cttctacaac tgttacattt aacgaagata
     5161 tggatattaa gaccattgat tctgaagtaa ctcctgttgt agaagaggtg acaggagata
     5221 aaaatgttca gcctacaaag gtagtcggaa caaatcaggt tgtgatcaag acacgttctc
     5281 tgaatcagag cgaacgtgaa gctctgcaga gtgcactggt tgagaaattt ggtgtagatg
     5341 acagcacgat ttccacagaa agtatttctt ctacagtaag tagtgaaatg cgtcgtgatg
     5401 cgatcgtagc cgttatagta gctacaatct gtatgcttct ttatatctgg ttcagattta
     5461 aagacatccg ttttgcaagc agtgcggtat tggcgcttct gcatgatgtt ctggttgtac
     5521 ttgcattcta tgctattgcc agagtatccg tcggtaatac atttattgcc tgcatgctta
     5581 caatcgtagg ttattctatc aatgctacaa tcgttatttt tgaccgtata cgtgagaacc
     5641 ttcacagtgg ttccagagaa aaactggcag aaattgtaaa cacaagtatc actcagactc
     5701 ttacaagaag tatttatacc tcttttacaa cttttgttat ggtagctgtt ctttatatca
     5761 tgggtgtttc ttctatccgt gaatttgcag cacctctgat ggttggtgtt cttgtcggtg
     5821 catattcttc tgtatgtatt acaggtgcgt tgtggtatgt gatgaaaaag aaatttgcag
     5881 gaaaaggaca gccggcaatt gttgcagctt ccgcatctgc aaagtcctct tcaaagccga
     5941 agaaagcacg tgatgtatca cagaaagatc cgactcagcc aaagaagaaa aacagaaaaa
     6001 gagtagctga acgtctggct gccgaagaag cagctaaaaa acagcagaat gatgatgctg
     6061 aataaaacaa taagtgtctg aaaaacaggc agacagaaat atcccggggt agaactccgg
     6121 gatattttta tgaggagaga aaatatatgg agaaatgggt aatagcagca aaaagagcag
     6181 attttaacca gatcggtcaa cagtttcata ttgatccggt gattgcgaga ctgatcagga
     6241 acagagatgt gatcggagaa gataagataa gagagtatct gtcaggaaca gtacaagagc
     6301 ttccttctcc ctggctgatg aaggatatgg aaaaagctgt agatatcctg gagaaaaaaa
     6361 tatcgcagaa agcaaaagtc cgtattattg gtgattatga tattgatggt gtgacctcta
     6421 catacatttt aatgaaaggc cttgcgagga tcggagcaga tgtggatact tatattccgg
     6481 acagagttgc agacggatat gggattcatg cacatcttat agaaagagcg gaaacggacc
     6541 ggatcgatac aatcgtgacc tgtgataatg gaattgctgc ggctgctgaa atccagatgg
     6601 caaaggataa gggaatgaca gtgattatta cagatcatca tgaggttcct tacagggagg
     6661 aaaagggaga acgccagatg gtgcttcctc cggcagatgc gattttgaat ccgaaacaat
     6721 atgattgtcc atacccgaat aaaaacctgt gtggggcagt ggtggccttt aaatatattg
     6781 cagcacttta cgagagattt ggtgttccgg cagaggagct ggaagattat tatgaactgg
     6841 cggctattgc aacagtagga gatgttatgg atcttcaggg agagaacagg attctggtaa
     6901 aagaagggct gtgccgtctg aaaaatacca aaaatcaagg attgcaggaa ctgatccgtg
     6961 caaattctct ggaagatgct aaaatcacag cttatcatat cggatttgtg ctgggaccat
     7021 gtatcaatgc cagtggcaga ctggatacag ctgcccgttc tcttgcactt ctcaatgcaa
     7081 aaacaaagga agaagcagca aggcttgccg gagatcttac agctcttaat cagagccgaa
     7141 aagctctcac tgagaaagga aaagaagagg caatccggat catagagact acagagctga
     7201 aaaatgacag agtactggta gtttatcttc cggattgtca tgaaagtctt gccggtatta
     7261 tagcaggcag gatcagggaa aaatatcaca ggcctgcctt tgtattgacg ggcggtgagg
     7321 caagtgcaaa aggaagcgga agatcaatag aaagttactc tatgtatgaa gaactggtaa
     7381 aatgtgcaga cctgatgata cagtttggag gtcatccgat ggcagcaggt ctttctatag
     7441 aagaaaaaaa tatagaagaa ttccggagac gcctcaatgt caactgtacg ttgacggacg
     7501 aagaattgcg tcctaagatc gtgattgatg tgccgatgcc tgtgtcttat attacaaaag
     7561 aactggtaga acagatttcg cttctggaac cctttggaaa agggaataca aaaccggtct
     7621 ttgcacagaa aaatctcaga gtgcttgatt acagtattat cgggaaaaat aaaaatgtag
     7681 taaaactaaa acttctcgat ccgcagggga tttcagtgga aggcatttat ttcggagaag
     7741 cagaggattt tgtgaacttt atcagggaaa aagacagtat ttctgttact tattatccgg
     7801 agatcaacag attcagggga cgagagagtc ttcagattat tattcagaat tactgttaat
     7861 attaccgcct gttttgtaac cgccggtaag cctggaaata caaatgtcag ggcttaacag
     7921 taacttgatt ctgaaataaa aaggtgatat actataaaat atttatgagc gaacagcaat
     7981 ataacacaca ctggaggaga aataaaatga agaaaattga agattatgta ttaagtatac
     8041 cggattttcc tgaaccgggg attattttca gagatattac aagtgttctg caggatgcgg
     8101 atggcctgca gttggcaatc gactccatgc aggactgtct taaggatata gatgtggacg
     8161 tgattgcagg aacagagtcc agaggcttta tctttggtgt accgatcgca tataatcttc
     8221 ataaaccatt tgtaccgatt cgtaaaaaag gcaaacttcc ccgcgaaaca gtatctgtaa
     8281 gctatgatct ggaatatggc agtgcagaga ttgaaatgca taaagattcc ataaaaccag
     8341 gtcagaaagt ggttatcgtt gatgatctga tcgcaacagg cggtacgatc gaagcagcga
     8401 tcaagctggt ggaacagctt ggcggtgagg ttgtcaaggt tgtatttctc atggaacttg
     8461 caggtttaaa gggacgcgaa agactgaatg ggtatgatgt agcgtccgta atttgttatg
     8521 atggtaaata agcacagctg attgtgcagg acaggcaggt gggagcatat gacagagata
     8581 acaaaaagta cagaagcaaa aaaagatgaa atgcaggttg aaaaagagaa gctggaatct
     8641 gtaaagagag cagatgcggc agtaaagacc atgcatgatt ttacaagtcc ggaggtgctt
     8701 tataaagaac tgataaacag tgttctgaag tatcatccat caacagatat ttccatgata
     8761 gagaaggcat ataaggttgc aagtgaagct catgaaggac agaagagaaa gtccggagag
     8821 ccatatatca ttcatccttt gtgtgttgcc atcattctgg cagatctgga acttgacaaa
     8881 gaaacgatag ttgcaggtct tcttcatgat gcagttgaag atacctggat gacctatgag
     8941 gaagtggaga aggaatttgg ttcagaggtt gcacttcttg tggatggtgt taccaagctg
     9001 ggacagttat cttattctgc ggataaagta gaagttcagg cagagaacct cagaaagatg
     9061 tttcttgcca tggctaagga tatcagagtt attctgatca agcttgcaga ccgtcttcat
     9121 aatatgcgta ccttacagta tatgcgtcct gaaaagcagc aggaaaaggc cagagagacc
     9181 atggatattt atgctcctat tgccatgcgt ctgggtattt ccaagataaa ggtagagctg
     9241 gatgacctgt cgctgaaata ccttaagccg gatgtatatt atgacctggt gcataaggtt
     9301 gccctgcgta aaagcgagag agaacagttt gtaggtgcga ttgtaaaaga agttaagaaa
     9361 catatggatg atgccaatat taaggcgcag gtggacggac gtgtaaaaca ctttttcagc
     9421 atctacaaga agatggtaaa tcaggataag actattgatc agatttatga tttatttgct
     9481 gtccgtattc ttgtagatac agtgaaggat tgttatgctg cccttggtgt gatccatgag
     9541 atgtataagc cgattccggg aaggtttaaa gattatattg ccatgccgaa acccaatatg
     9601 tatcagtcat tgcataccac attgatcgga cctaacggac agccctttga aatccagatt
     9661 cgtacttatg aaatgcacag aactgcagaa tatggtatcg ctgcacactg gaaatataag
     9721 gagtcgtctg acggaaaagc tcctgtaggt aagagtgagg aagagaaact gaactggctg
     9781 cgtcagattc tggaatggca gagagacatg tctgataaca aagaattcat gagtcttctg
     9841 aagaatgacc tggatctttt tgcggacagt gtttactgtt ttactccaca gggagatgtt
     9901 aaaacacttc caagtggttc tacaccggtg gattttgcat acagtgttca cagtgcagtc
     9961 ggaaataaga tggtaggtgc cagagttaac ggtaagctgg ttcctattga atatgagatc
    10021 aaaaacggtg accgtattga gatcattact tcccagaatt ctcagggacc aagccgcgac
    10081 tggctgaaac tggttaagag tactcaggca aagaacaaga ttaaccagtg gttcaagaag
    10141 gaattaaaag aagataatat tcttaagggt aaggagatgc ttgcgcagta tgcgcgcgca
    10201 aagggattta agattgcaaa ttatacaaaa acccagtatc tggaggctgt tttgcgtaaa
    10261 tatggtttca gggactggga ttcagtactt gctgcaattg gtcatggcgg attgaaagaa
    10321 ggtcaggttt tcaataagct ggtagaggct tatgataagg aaaataagaa gaatctgaca
    10381 gatgagcagg ttcttgaggc tgcttctgag acacaggaga agcttcacat tgccaagagc
    10441 aagagcggca ttgtggtaaa aggaatccat gatgtggcag tccgtttttc caagtgctgt
    10501 aatccaatcc cgggtgatga gattgtaggc tttgttacaa gaggacgtgg aatcacaatt
    10561 catcgtacag attgtgtcaa tgtgctgaat atgtctgaga cagacaggac acgactgatc
    10621 gaggcagagt ggcagcagcc tgataccaag gaaaaagaga agtatatggc tgagattcag
    10681 gtttatgcaa ataaccgtac agggcttctt gtggatcttt ctaaaatatt tacagaacgt
    10741 aagatcgacc tgcgaagtat caacagccgt acaagcaagc aggagaaggc gactatttcc
    10801 atgagttttg agattggaag caaagaggaa ctgcgttccc tgatcgagaa gatccgtcag
    10861 gtagagagtg tcattgacgt agagagaact acaggctgat catggaaaaa tctgctgaaa
    10921 cattatttta tggaactgct gcagattgac agaaaggaat aacatgaaga atttagaatt
    10981 acagaaatgt atattaggac ctgtatatac aaattgctat ctccttaaga ataaagaaac
    11041 cggagaactg atcattgttg atcccgcaga ttgtccggag aagattgaaa tgaagatttc
    11101 ccggatgaat ggaaaaccgg tggcgattct tcttacccat ggacattttg accacattct
    11161 ggctgcacag gcagtaaagg agaaatataa tattccgatt tatgcctgtc gtcaggaaga
    11221 ggagatgctc cgcgaacctt cgatcaatat gactgtacat tatggacagg gatgttctat
    11281 tgtgccggat gtatttctgg aggatctgga tgttatcaga ctggcgggat tttccgttca
    11341 gatgatccat acaccgggac ataccaaagg aagctgctgt tattatctga aagatgaagg
    11401 tgtattgttc agcggtgata cagtgttcta tggctctgtt ggaagaacgg attttccggg
    11461 tggaagtaca gcagaaattg tgagaagtct ccataaactg gtagattcgc ttcctgaaga
    11521 gaccgaggtt ttccccggac atgatgcatc taccactatt ggttatgaaa agaggtataa
    11581 tccatttgtg taaaataggc attctgttta agaacagaga ttttgaacat gatgtttatg
    11641 aactgatcaa agcgttttat cccgaagcgg agatacatac tctttatgaa aatggtgaag
    11701 cagagtatga cctccgcttc agtgtggaac gggataatga cagttatatc ataaaatacg
    11761 aaaggacaga gaatctgtcg aaacaggaaa cagagcaaaa aggggtaatt tccgcagaca
    11821 tactttctaa agagaatgca ggctgtggaa tacaggatgc tcatgctctg agaaaagaga
    11881 ataaagataa tatcaaatat gctctgtatc agttgttggt aaaactgacg ggcagaactc
    11941 ttccatgggg aaatctgaca ggaatacgtc ctgccaaact ggcaatggga atgatcgaat
    12001 ccggaatgaa aaatacggaa gcagcccggg agatgcgtga gagatatctg gtgagtccgc
    12061 agaaaacagc gcttgccatc actattgcaa acagggaaag agagattctg aaggatattg
    12121 actatgaaaa tggatacagc ctttatattg gaatcccgtt ttgcccaagt atctgtctgt
    12181 attgttcctt cagctcctat ccgctgaaag tgtgggagaa gagaacagat gaatatgtgg
    12241 aagctctctg ccgtgaggta agagagactg ctcttatgat gaagggaaga aaactggaca
    12301 ccatctatat tggcggcggt accccgacta cactgcttcc acatcagatc cgtaagctcc
    12361 tggatacagt gggagaagct tttggctatg aaggactggc agagtttact gtggaagccg
    12421 gcagaccgga cagtattaca cgtgaaaagc tgatggcgat cagggagtat ccggtaacaa
    12481 gaatttccgt aaatccacag actatgaatc aggaaaccct ggatattatc ggccgcagac
    12541 atactgtgga gcagacaaaa gaagcgtttc atctggcacg agagctggga tacgataaca
    12601 ttaacatgga tctgatcgta ggactcccgg gtgaggatat tcacatggta gagcggactc
    12661 ttgaacaggt tcgtgaactg gcaccggaca gtattaccgt acattcactg gcagtgaaac
    12721 gtgcagcaag gctgaatatt tttaaagaga aatatcagga aatgtctttt gagaataatc
    12781 aggagattat ggatctgacc atgaaaactg cgtatgaaat gggaatgggt ccttattatc
    12841 tgtacagaca gaagaatatg aagggaaatt ttgaaaatgt tggctatgca aaggttgaca
    12901 aagcgggaat ttacaatata ctgattatgg aggaaaaaca gcctatcatc gcactggggg
    12961 caggcggttc ttccaagctg gtctttgacc atggacagag aattgaacgt gtggagaatg
    13021 taaaagacgt ttctaattat atttcccgca ttgatgagat gatcgagaga aaacggacag
    13081 caatagctac ctggctgtag gatgtggagg taacattttg gacacagtac aaaagacagc
    13141 agcaggttca cagcagagga tcctggaatt tgaccttgct tctgaactgc atcatggaat
    13201 gctggtaagt aatctggctt atgcggttgc agaggagatg ggactgccgc atgaacagtg
    13261 ttatgagctt gcaatagcag gaatgctcca tgatatagga aagctgaagc tgacaagtta
    13321 tattaacgga caggagcagg atcctctggt gatcgaggaa ctgaagtatg tccggatgca
    13381 ttctgcattg ggatatgagg aacttaaagg gcagggatat tcggattttg tattggagag
    13441 tatcctgtac catcatgaga attatgatgg tagtggatat ccgtccaata aagcaggtga
    13501 tgatataccc ataggtgccc ggatactcag agtctgcgat gtata
//
