LOCUS       c00548_gnlPro..        13105 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BJLCDPEL_548.
ACCESSION   c00548_gnlPro..
VERSION     c00548_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 02:43:17
            Original ID  :: gnl|Prokka|BJLCDPEL_548
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13105
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13105
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4636:9960]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4637..9960
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13105
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13105
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(123..884)
                     /locus_tag="ctg548_1"
                     /transl_table=11
                     /translation="MNTVQVKNTVIGEGRPKICVPIVGKAKTDILEEAKKITTLPVDVV
                     EWRVDWFDDVFATEKVLETAKELQEVLKDIPVLLTFRTSKEGGEKEISANDYAALNIAA
                     AQSGYVDLIDVEAFTGDDIVKTIIDAAHEAGVKVIASNHDFFKTPEKEEIIRRLRMMQD
                     FGADIPKMAVMPTCKQDVLTLLSATLEMSEKYADRPIITMSMAGTGVVSRLTGETFGSA
                     LTFGAASKASAPGQVGVHELKKVLDIIHSSL"
     CDS             complement(1153..2031)
                     /locus_tag="ctg548_2"
                     /transl_table=11
                     /translation="MAERITGHTELIGLMAYPIRHSSSPAMQNEAFAKLGYDYAYLAFE
                     VGADEIEDAVKAIRTLKMRGSNVSMPNKTLVGKYLDELSPAAELCGAVNTIVNDNGHLT
                     GHITDGIGFMSALKDNDIDVIGKKMTIVGAGGAATAIEIQAALDGVAEITIFNRKDEFW
                     DRAVSTVEKINTKTSCHAVLYDLADLDKLKAEMDDSFIFVNATGVGMKPLEGQSVVPDK
                     SYFRPELIVIDVPYSPLETKMRSMAKEVGCKTMNGLGMMLFQGSAAFELWTGEPMPIEH
                     MKEILHISYDD"
     CDS             complement(2068..3117)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) baiH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg548_3"
                     /sec_met_domain="baiH (E-value: 3.4e-55, bitscore: 177.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRGLIAEPAWVNKVATGRECDLRKCISCNIGCAGNRIGFNRPIR
                     CTVNPAVLEGDVYKNQKVNKNCNVVVIGGGTAGLEAACTAAEVGCNTFLLEKGETLGGL
                     ASVISKIPAKKRLADFPNYLIHRAEQLENLYIFTNTEGTPENIRKFHPNLIVSSTGSAP
                     LLPPIRGLHDRIDKEGSKVASILGMINHINDYPEDMTDKKVVVVGGGAVGLDVVEFFAA
                     RNAAISIVEMMDQIGRDLDPVTKNDMKDQMKKHHVAQLTKTALQEVKDSSFLVKDAEGE
                     RELPFDYGFVCLGMRAQGQLFVKLSDAFVSDDVEILNIGDSKRARRIIDGTLEGRNILN
                     TLTQMGYLQ"
     CDS             complement(3140..4021)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) baiH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg548_4"
                     /sec_met_domain="baiH (E-value: 8.2e-78, bitscore: 251.9,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIKNRIVMMPMGTNYGEQNGEMSFLHINYYKERAKGGTGLIIVE
                     NASVDSPQGSNGTTQLRIDHDNYLPRLYKFCEEIHKYGTCIAIQINHAGASAVSARTNM
                     QPVSASDIPSKEGGEIPRPLSVEEIHHIVKKYGEAAKRAQAAGFDAVEIHAGHSYLISQ
                     FLSPLTNKRTDEFGGSVENRTRFCRMVIEEVRKQVGPFFPIMLRLSADELMEGGNTLED
                     TLEYLEYVQDEVDIFDVSCGLNGSIQYQIDANYMKDGWRSYMPKAVREKFGKPCISMGN
                     IRNPKVNRADPR"
     CDS             4637..6073
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg548_5"
                     /sec_met_domain="CT_Vparvula (E-value: 7.3e-137, bitscore:
                     446.5, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPS
                     DGVITGYGVIDDKLVYVYSQDASVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAG
                     IRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGK
                     MFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDT
                     DNYTECTDDLNRVCADLANCADDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGAT
                     VGAVANRSEVYDAEGKKTETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMAT
                     LCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEI
                     GMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
     CDS             6121..6843
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg548_6"
                     /sec_met_domain="OAD_gamma (E-value: 7.6e-28, bitscore:
                     86.8, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFLVMAALVIGSTSVVFAADKVDDTVKSTLVTTAEGLTDAIVQL
                     KDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQYTVTVPLKFEK
                     ADANFVYVFDSQGTPTSMSVDVQYGMGKTLQRAGLNTLMGIGTVFVMLILLSLLISLFR
                     FIPNPEAKKAAEAKAAKAAKEAEAAAIAQTAPAQAEENLADDGELVAVIAAAIAAAEGT
                     TTDGFVVRSIRKVKRNRR"
     CDS             6871..7239
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.1; E-value:
                     5.3e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg548_7"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1e-20, bitscore:
                     63.1, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAA
                     APAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVIILESMKMEIPVVAPQDGTIASI
                     DVAEGASVENGDTLATMN"
     CDS             7256..8404
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg548_8"
                     /sec_met_domain="OAD_beta (E-value: 5e-157, bitscore:
                     511.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVTETLSNLIHQTAFFNLTWGNYLMIAVACVFLYLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTD
                     FGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKL
                     GQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVI
                     TIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSA
                     EAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGKINPLIGSAGVSAVPMAARV
                     SQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             8548..9960
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg548_9"
                     /sec_met_domain="HMGL-like (E-value: 6.1e-47, bitscore:
                     150.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 4.8e-59, bitscore:
                     189.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGY
                     HAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTMEYWTD
                     IAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLK
                     AVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDE
                     ALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGD
                     EKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDE
                     KAADKKNGAYPV"
     CDS             10072..11544
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg548_10"
                     /sec_met_domain="HI0933_like (E-value: 2.8e-81, bitscore:
                     262.9, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMPEVHIYIDRSEAETWNHDEIDNLQGKINTGEYSMSKVIIIGGG
                     AAGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKF
                     LYSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHL
                     HTAVQEIVKKPVTESVTDSVTDSVNTLESEAALTESGSDAGKSRKGKKSSDIQQEKITG
                     VILTDGTFIEGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDY
                     VPKLQGLSLKNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNG
                     ELSAYLDLKPALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEK
                     KIHDISREERQHFIDLIKAFPFTITGMGEFKEAIITRGGVSVKEINPGTMESKKISGLY
                     FAGEVLDLDAVTGGYNLQIAWSTAYLAVQAIQ"
     CDS             11730..12401
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg548_11"
                     /sec_met_domain="Cytidylate_kin (E-value: 3.8e-78,
                     bitscore: 251.7, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGCNIAIDGPAGAGKSTIAKKVAKELSFIYVDTGAMYRAMALYLL
                     NHGVNGENQEEIEAVCSGADISIEYKNGEQIVILNGENVNAMIRTEQVGNMASKSSANP
                     KVRAHLLKLQRTLAEKNDVVMDGRDIGTTILPNAEVKIYLTASADTRAKRRALEYEQKG
                     ESFDLDQIRKDIIERDERDMNREISPLKQADDAVLVDSSEMGIDQVVDAILDVYNKKIQ
                     K"
     CDS             12590..13105
                     /locus_tag="ctg548_12"
                     /transl_table=11
                     /translation="MKVKVAETAGFCFGVKRAVDKVYELIGTEQKPIYTLGPIIHNEGV
                     VADLEARGVHVITEADLDSPDDTLQNGTVVIRSHGVGKAIYDKLKEKNISYVDVTCPFV
                     LKIHRIVEKESLAGNHIIIIGDKDHPEVQGICGWCQGPYTVIRNKEEAEVFVPPKGKKI
                     SIVSQTTFK"
ORIGIN
        1 ttttgagtaa atatttattg ccatatatct catgggataa caatcatctg ttgccgaaga
       61 tgagtgatat cagacaacta tgggcaagaa taacatctga tatcacatca ttcatcaaca
      121 gatcacaggc tgctgtgaat gatatccagc acctttttta attcatgcac accgacctgt
      181 cccggagcag aagctttgga agcagcaccg aaagtgagag cggagccgaa tgtctcacct
      241 gtcaggcggc tgacaacgcc tgttcctgcc atggacatgg taatgatcgg gcggtctgca
      301 tatttctcag acatttccag agtagcagag aggagtgtaa gaacatcctg tttgcaggtc
      361 ggcataacag ccattttcgg aatatcagca ccgaaatcct gcatcatacg aagacgtctg
      421 ataatctcct ccttctcagg agtcttaaag aaatcatggt tggaagcaat taccttcaca
      481 cctgcctcgt gagcagcgtc aatgatcgtt tttacaatat catcacctgt aaatgcttct
      541 acatcaatta aatctacata accgctctga gcagctgcaa tatttaaagc agcatagtca
      601 tttgcagaaa tttctttctc accgccttct ttggaagtac ggaatgtaag gagaacagga
      661 atgtctttta aaacttcctg aagctcttta gcggtttcta atactttctc agtagcaaag
      721 acatcatcaa accagtctac acgccactca actacatcaa caggaagagt agtgatcttt
      781 ttggcttctt cgagaatgtc tgtttttgct tttcctacga tgggaacgca gatcttaggt
      841 ctgccctcgc cgatcacagt gttttttacc tgaactgtgt tcatctgttt atcctcatat
      901 tttctgttgt attatagtag ttccggatta ttatggaact gttataagaa taaccgtaac
      961 ataaccgcat gatcaacagc tttttgaagc aaactgcagg atatgtacat tctgcgcgga
     1021 gtaatatatc agtacatctc ctgcagtacg ccgaaaagcg gtatatatca aatattatgt
     1081 gcagaaagat cagtgaaatg atttgttctg catcacaata tgagatatct ttactgaaga
     1141 taccatcagg tatcagtcat cataggagat gtgaagaatc tctttcatat gttcgatagg
     1201 cattggttcg cctgtccata actcaaatgc agcggaaccc tggaataaca tcattcccag
     1261 accgttcatt gtcttgcatc ctacctcttt ggccatggaa cgcatctttg tctccagagg
     1321 agagtaagga acatcaataa cgatcagctc aggacggaag taagatttgt ccggaacaac
     1381 ggactgtcct tccagtggtt tcattcccac acctgtagca ttgacaaaga taaaactatc
     1441 atccatctca gctttcagtt tatcaagatc tgccagatca taaagaactg catggcagga
     1501 tgtctttgtg ttgatctttt ctactgtgga tactgcacga tcccagaatt catccttgcg
     1561 gttaaagatt gtgatctcgg caacgccgtc caaagcagcc tgaatctcga tagcagtggc
     1621 agcaccgcct gcaccgacga tagtcatttt ctttccgatc acatcaatat cattatcttt
     1681 cagggcagac ataaatccga taccgtcagt gatatgacct gtaagatgac cgttgtcatt
     1741 tacgatcgtg ttaactgcac cgcataattc tgctgcagga gaaagctcgt ccaggtattt
     1801 tccaaccaga gttttgtttg gcatggaaac attggatcct ctcattttca gagtacggat
     1861 tgcttttact gcatcctcaa tctcatctgc gccaacctcg aaagcaaggt aagcgtagtc
     1921 atacccgagt tttgcaaaag cctcattctg cattgcagga gagctggagt gacggatcgg
     1981 gtaagccatc agaccgatta attcagtatg tccggtaatt ctttcagcca ttataatatc
     2041 ccctttcgta ttttgttgta aaggttttta ttgaaggtat cccatctgag tcagtgtatt
     2101 aaggatattt cttccttcca gagttccgtc gatgatcctt cttgcacgtt tgctgtctcc
     2161 gatgttcagg atctcaacat catcagaaac aaaagcatcg gaaagcttta cgaaaagctg
     2221 tccctgagct ctcataccaa gacatacgaa tccgtagtca aatggaagct cacgttcacc
     2281 ttctgcatct tttacaagga aagagctgtc ttttacttcc tgaagagctg tctttgtaag
     2341 ctgggccaca tgatgtttct tcatctggtc cttcatgtca ttctttgtaa caggatccag
     2401 gtcacgtccg atctgatcca tcatctccac aatagaaatc gcagcatttc ttgctgcaaa
     2461 gaattccaca acatcaagac caacagcgcc gccgcccaca acaacaacct tcttgtctgt
     2521 catatcttcc ggatagtcat tgatgtgatt gatcattccc aggatagaag caaccttgct
     2581 gccttctttg tcaatgcggt cgtgaagtcc cctgatcgga ggaagcagtg gtgcggaacc
     2641 tgtggagctt acgatcagat tcggatggaa cttgcggata ttttccggtg ttccttctgt
     2701 gtttgtgaag atataaagat tctcaagctg ctctgctctg tggatcagat agttcgggaa
     2761 atcagccaga cgtttctttg caggaatctt agagatcaca gaagcaagac cgccaagagt
     2821 ttcacccttt tccagaagga aggtattaca gcctacttct gcggctgtac aggcagcttc
     2881 cagtccggca gtaccgcctc cgattactac aacgttacaa tttttgttca ctttctgatt
     2941 cttataaaca tcaccttcca gaacagccgg gtttacagta cagcggatcg gacggttaaa
     3001 gcctattctg tttcctgcac atccgatgtt acaggagata catttgcgaa ggtcacattc
     3061 tctgcctgta gctactttat tcacccatgc aggttctgcg ataagaccac gtcccatacc
     3121 gatcaggtct gcatcgccgt cagcgaggat ctgctcggtt aaccttcggg ttacggatat
     3181 ttcccatgga gatacatggt ttgccgaatt tctctctgac agctttaggc atataggaac
     3241 gccatccgtc tttcatgtag ttggcatcga tctgatactg gatagaaccg tttaaaccgc
     3301 aggaaacatc gaagatatca acttcatcct gaacatattc cagatattca agagtatcct
     3361 cgagagtgtt gccgccttcc atcagctcat ctgcgctgag acggagcatg atcgggaaga
     3421 aaggtccgac ctgttttctt acttcctcaa tgaccatacg gcagaaacgt gttctgtttt
     3481 ccacagatcc gccgaactca tctgtacgtt tgtttgtaag aggagagagg aactggctga
     3541 tcagatagga atgtcccgca tggatctcta ctgcgtcaaa acctgcagcc tgggctctct
     3601 ttgcagcctc gccgtatttc tttacaatgt gatggatttc ttccactgat aacggacgcg
     3661 ggatctctcc gccttctttg gacggaatat cagatgcgga aaccggctgc atatttgtac
     3721 gtgcggaaac agcggaagca cctgcgtggt tgatctggat cgcaatacag gtaccatatt
     3781 tgtggatctc ttcacagaat ttgtacagac gcggcagata gttgtcgtgg tcaatacgaa
     3841 gctgagtagt tccgttggaa ccctgcggag aatctacgct tgcattctct acgatgatca
     3901 gacctgtgcc gcctttggca cgctctttat aataattaat gtgaagaaaa ctcatttcgc
     3961 cgttctgttc cccgtaattg gttcccatag gcatcataac gatacggttt ttgatagtca
     4021 tattttttac tgtgagtggt gtgaaaatat gctggtaatt gcttttcatt acgtctttcc
     4081 tcctgaaatt ttctgttgga tctatagctg ttcagtgctt tagctgtggc ctgaatttct
     4141 ttgatgtgtt aattatataa cgggataatc cataaatcta attgataatt cgtgctatat
     4201 aataaaaaac atctatggtt ttccgtgcac tgtccgcgta ctgaatgaaa gcattcgcaa
     4261 ctgcatccac atcatgggaa aatcctgctg aatctgtatg gctatagtat tttttcaccg
     4321 agctgcgctg agacttttat acctgtgtag tcggatttgc agacaagtga gtggtatagt
     4381 tacttcaaac acgctctggt ttacgggaga gggtgaaata caggacaata caaaataacc
     4441 gtaataccct ctattaaata ggaagaaata ctcaaaaaaa caaaatttgg agaaacctga
     4501 caaatttttc tgctatattt ttaacgaaaa tgacaaataa atgttgaaat tttctgccgg
     4561 aaaaggtaaa attaaaatcg gctaaatttt tgggttaact tttaaatatt ctcataaaga
     4621 tggagggcaa acaagaatga gtaatgcaac acaaagctta gcaggcacaa gaattacttc
     4681 tttgcttgac gcaaacagtt ttgtcgaaat cggacagggt gtaacagcca gatccacaga
     4741 tttcaacatg actgcaaaca aggcaccatc tgacggtgtt atcaccggat atggtgtgat
     4801 cgatgacaaa ctggtttatg tatacagcca ggatgcatct gtattaaacg gtactgttgg
     4861 tgaaatgcat gcaaagaaga tcacaagact ttatgatctt gccatgaaaa caggcgctcc
     4921 ggttatcgga cttgttgact gtgcaggtat ccgtcttcag gaagcaacag acgcactgga
     4981 agctttcgga cagatctatc tgaaacagac actggcatcc ggtgtgattc cgcagatcac
     5041 agcaatcttc ggaacatgcg gcggtggtat ggcagttatc ccgtccctga cagatttcac
     5101 attcatggaa tccaaaaaag gaaaaatgtt cgtcaacaca ccaaacgcac tggaaggaaa
     5161 caacacagac aaatgcgaca cagcagcagc tgatttccag agcaaagaga caggtgtgat
     5221 cgatggcgtt ggtacagagg atgagattct tggccagatc cgttccttag tatcacttct
     5281 tccttctaat aatgaagaca cagacaatta cacagagtgt acagatgatc ttaaccgcgt
     5341 atgcgcagat cttgcaaact gtgcagatga cacagcaatc gcactttccc agatcgctga
     5401 caacggtgaa ttcttcgaga caaaagcaga ctatgcaaaa gacatggtta caggctttat
     5461 ccgtttaaac ggcgctacag taggtgctgt tgcaaacaga agcgaagtat atgacgcaga
     5521 aggcaagaaa acagaaacat ttgacggaag catctctgca agaggcgcaa gaaaagcagc
     5581 agatttcgtg aaattctgcg acgcttttga tattccggta cttacactta caaacgcaac
     5641 aggcttcatg gcaaccttat gcagcgagaa gatgatggcg aaatccgtag gtgaactggt
     5701 agctgcattc gcagatgcaa ctgttccgaa ggtaaatgtg atcatcggca aagcttacgg
     5761 tacagcttac gtggcaatga acagcaaatc tatcggtgca gaccttgtat atgcatggga
     5821 taacgcagag atcggtatga tggatgcttc cctggcagcc aagatcatgt atgcagatgc
     5881 agatgctgct gaactgaatg aaaaagctgc tcagtacaga gagcttcaga atggtgttgc
     5941 ttccgcagca gcaagaggct atgttgacac tgtgatcagc ccggctgaca caagaaaata
     6001 tgtaatcggt gcatttgaga tgctgttcac aaagagagaa gatcgtccgt ctaagaaaca
     6061 tggaacggtc taagcggggt gacgcatatg aaaatgatca aaaaaataac ttctgtattc
     6121 atgacatttc tcgtaatggc tgcgctggtg atcggcagca cctctgtggt atttgccgca
     6181 gataaggttg atgatactgt taagtccaca ctggtaacta cagcagaagg actgacagat
     6241 gccattgtcc agcttaaaga tgaagaaatc gagaattaca tgagttcagg agatgacttt
     6301 acaacaagtg ccatgcagtc ctggcagaca tccaaggatg aacttggcgc aaagaaggac
     6361 agcaatggtg aaactactgt aactttcaaa gatgatcagt acacagttac tgttcctctt
     6421 aaatttgaga aagcagatgc aaactttgta tatgtctttg actcacaggg aacaccgact
     6481 tccatgtctg tagatgtaca gtatggtatg ggcaagactc ttcagagagc aggtcttaat
     6541 actctgatgg gtattggaac tgtattcgta atgttgattt tattaagcct tctgatctct
     6601 ctgttcagat tcattccgaa tccggaagca aagaaagcag cagaagcaaa agcagccaaa
     6661 gctgcaaaag aggcagaggc agcagccatc gcacagacag cacctgcaca ggcagaagag
     6721 aaccttgcag atgacggaga gctggtagct gttattgcag cagccatcgc agcagcagaa
     6781 ggaactacaa cagacggctt cgtagttcgt tctatccgta aagtaaaaag aaatagaaga
     6841 taattgtcat ttatttagga ggattttaaa atgaaaagct atacaattac agtaaatggt
     6901 acagcatatg aagtaactgt tgaagaaaca ggaagcgtat ccgcacctgc agcagctcca
     6961 aaagcagcac ctaaggctgc acctgcagca gctccgaaag cagcagctcc tgcagcaggc
     7021 gccggcgcag tgaaagtaac tgcttccgta cctggtaaag ttgtcaaagt agcagcaagc
     7081 gttggacagg cagtaaaagc cggagacagc gtaattattc ttgaatccat gaaaatggaa
     7141 atccctgtag tagctcctca ggacggtact atcgcaagca ttgatgttgc agaaggtgcc
     7201 tctgtagaaa acggagatac tttagcaaca atgaactaag acgggaggta gtcaaatgtc
     7261 ttatgtaaca gaaacattgt ccaacctgat tcaccagaca gcattcttca atctgacatg
     7321 gggcaattac ctgatgatcg cagtagcctg cgtattcctt tatcttgcta tcaagaaagg
     7381 attcgagccg cttctgcttg ttcctatcgc attcggtatg ctgcttgtaa atatctatcc
     7441 ggacattatg gcaaacccgg aagatatgtc caatggtgta ggtggacttc ttcattattt
     7501 ctacatcctt gatgagtgga gtatcttacc atccctgatc ttcatgggtg taggtgccat
     7561 gacagacttc ggtccgctta tcgcaaaccc aatcagcttc ctgatgggtg ctgcggcaca
     7621 gcttggtatc tatgcagctt acttccttgc aatcttcctt ggattcaacg gaaaagcagc
     7681 agcagctatc tccatcatcg gtggtgctga cggcccgact tccattttcc ttgcaggtaa
     7741 acttggacag tctgcactga tgggaccgat cgcagtggca gcatattcct atatgtcact
     7801 ggttccgatc atccagccgc ctatcatgaa actctgcaca acagagaaag aacgtaagat
     7861 caaaatggat cagcttcgcc cggtttccaa actggagaag atcctgttcc cgatcgttat
     7921 cacaatcgtt gtctgcctga ttctgcctac aacagctccg ctggttggta tgctcatgct
     7981 tggtaacctg ttcagagagt gcggtgttgt aaaacagctg acagaaacag cttccaatgc
     8041 cctgatgtat atcgtagtta tccttctggg tacatccgta ggtgcttcca caagtgcaga
     8101 agcattctta aacgcagata ctctgaagat cgtagtttta ggtcttgttg cattcgcaat
     8161 cggtacattc ggcggatgta tgcttggtaa actgctctgc aaactgactc atggaaagat
     8221 caatccgctg atcggttccg caggtgtatc cgcagtacct atggcagccc gtgtatccca
     8281 gaaagtgggt gcagaggcag atcctacaaa cttccttctg atgcacgcaa tgggcccgaa
     8341 cgttgccggt gttatcggta cagccgtagc agccggaaca ttcatggcta ttttcggagt
     8401 ataaccaaat caagcaagct atcttgcttg tatcaggagg agtgcaactc cttctgataa
     8461 gctgcggagc agctatttgg tgtagagctg cgtagcgaag cggattgcga atatccgatt
     8521 aaacagaact ataaaggaga tttaataatg gcagaattag agaaaaaacc tgttaaaatt
     8581 gtggaaacca ttctccgtga tgctcatcag tcccagatcg caacacgtat gaccacagaa
     8641 cagatgcttc cgatcgtaga taaacttgat aaagtcggct atcacgcagt agagtgctgg
     8701 ggtggtgcaa cattcgatgc atcccttcgt ttcctccacg aagatccatg ggaaagactt
     8761 cgtaaattac gtgacggctt caaaaacaca aaacttcaga tgcttttccg tggacagaac
     8821 atccttggat accgtccata tgcagatgac gttgtagaat acttcgtaca gaaatctgct
     8881 gcaaacggaa tcgacatcat ccgtattttt gactgtctca atgaccttcg taaccttcag
     8941 acagcagtaa gcgctgcaaa caaagagaag gctcatgcac aggtagctct ttcctataca
     9001 ttaggagatg cttacacaat ggaatactgg acagacattg caaaacgtat tgaagatatg
     9061 ggcgctgatt ccatctgtat caaagatatg gcaggtcttc tccttccaaa caaagctaca
     9121 gagcttgtaa cagcattaaa agaaacagtt aagatcccga tcgaccttca tacacattac
     9181 acctcaggtg tagcttccat gacttactta aaagcagtag aagcaggtgt ggatatcatc
     9241 gatacagcaa tgtctccatt tgcactggga acatcccagc ctgcaacaga ggttatggtt
     9301 gagacattca aagatacacc atacgacaca ggatttgatc agaaacttct ctccgagatt
     9361 gctgactact tccgtccgat ccgtgacgaa gctcttgaca gcggactgct caatccgaag
     9421 aaccttggtg ttaacatcaa gactttactg taccaggtac cgggcggtat gctctccaac
     9481 ctgacttccc agctgaaaga acagcacgca gaagacaaat tctacgatgt tctcgaggaa
     9541 gttccgcgtg tacgtaaaga ccttggtgaa ccgccgcttg ttactccgtc ttcccagatc
     9601 gttggtacac aggctgtatt caacgtactt atgggcgaga gatacaaaat ggttacaaaa
     9661 gaaacaaaag atatcctgtt aggaaaatac ggcgcaactg taaaaccgtt taatccggaa
     9721 gtacagaaga agtgcatcgg cgatgagaaa ccgatcacat gccgtcctgc agaccttctt
     9781 gacaacgagc ttgagaaact tgagagcgaa atggctcagt acaaggaaca ggatgaagac
     9841 gtattaacat acgcactgtt cccacaggta gctatggact tcttcaaata ccgtcaggct
     9901 cagaaaacaa aagttgacga gaaagcagct gacaaaaaga acggagcata tcctgtataa
     9961 ttgatcagta attaaatatg tccaaacgaa aaaaggagct tgcgtaagca ggctcctttg
    10021 cgttattatg aaagaatatg atacccggga atataatgtg ccaatgggta tatgatgcca
    10081 gaggtacata tctatattga tcgtagcgaa gcggagacgt ggaaccatga tgaaatagac
    10141 aatctgcagg gtaaaataaa tacaggagaa tattccatga gcaaagttat aataatcggc
    10201 ggcggagccg ccggaatgat ggcaggggtt tttgcagccc gtaaccatca tgaagttcat
    10261 atattagaga agaacgagaa actgggaaag aaagtcttca tcacaggaaa aggcagatgc
    10321 aatgtgacaa atgcctgcga cacagaagaa ctctttcctg caatgatgag caatcccaag
    10381 ttcctttaca gcagtttcta ttcatttacc cctcaggatg taatggagtt ctttgagaaa
    10441 gcaggtgtcc ctctgaaggt agagcgtgga aacagagtat tcccacagtc tgaccattct
    10501 tcagacatca tccgcgctct ggagcgtgag ctgaagaaag caggagcaaa gattcatctt
    10561 cacactgctg tgcaggaaat cgtaaagaaa cctgtaacgg aatctgtaac agattctgta
    10621 acagattccg taaataccct tgaatcagaa gccgcattaa cagaatcagg atctgatgca
    10681 ggaaaaagca gaaaaggaaa aaaatcatct gacatacagc aggagaagat cacaggagtt
    10741 atacttacag atggtacttt catagaaggc gatgcagtca tcgtggcaac cggcggattc
    10801 tcttatcaga gtaccggttc cacaggtgac ggataccgct ttgcaagaga actgggactg
    10861 aaagtcacgg acattgctcc ctcccttgtg ccattaaaga caaaagaaga ctatgtccct
    10921 aagcttcagg gactttccct taagaataca ggacttacca taaagaatgg aaagaaagta
    10981 ctctatgagg attttggaga gatgatgttc acccatttcg gagtcacagg tcccatgatc
    11041 ctgtccgcca gtgcccacat tggtgcaaaa ctggcgaaag caccaaacgg cgaactgtcc
    11101 gcatatctgg atctgaagcc ggcacttacc agagaacagc tggatgccag gatcctgcgc
    11161 gaatttgaag caggaccaaa caaacagttc aagaacgtga ttggcgtact tttcccgtca
    11221 tctctgactc cggtaatgct ggaactgggt ggaatccccg cagagaagaa aatccacgac
    11281 atctctagag aagaacgcca gcacttcatt gaccttatca aagctttccc cttcacaatc
    11341 acaggaatgg gtgagtttaa agaagccatc atcaccagag gcggcgtctc tgtcaaagag
    11401 atcaaccccg gaacaatgga atcaaagaaa atctcaggtc tttacttcgc aggcgaggta
    11461 ctggatctgg atgcagtgac aggtggatat aacttacaga ttgcctggtc taccgcatat
    11521 ctggcagtac aggccataca gtaagctgct tactatagaa acaacagaaa caagcagatg
    11581 atgagtaccg tgtatgcgaa ttatatctat gattcggtta tgagcaagta gcgaagcgga
    11641 ttgagaatat ctgcttgact gattaataaa cattaataat aaaacagaga aaatttgttt
    11701 gaataataga aacaggagga accacgaaaa tgggatgtaa catagccatc gacggacctg
    11761 caggagcagg aaagagcacc atcgcaaaga aagtagcgaa agaattatca tttatctatg
    11821 tagatacagg agccatgtac agggcaatgg ctttatatct tttgaatcat ggcgtaaacg
    11881 gagaaaatca ggaagagatc gaagccgtat gttccggcgc tgacatctcc atcgaataca
    11941 aaaacggaga acagattgtt atcctcaacg gagagaacgt aaatgctatg atccgcactg
    12001 aacaggtagg aaacatggca tccaaaagct ccgcaaaccc gaaagtcaga gcccaccttc
    12061 tgaaacttca gagaactctg gcagagaaaa acgacgtagt catggacggc agagatatcg
    12121 gcacaaccat ccttccaaac gcagaagtaa aaatctacct cacagcaagc gcagacacca
    12181 gagcaaaaag aagagcactg gaatatgaac agaagggaga atccttcgac ctggaccaga
    12241 tccgaaaaga catcatcgag cgcgacgaac gcgacatgaa ccgcgaaatc tcccctctga
    12301 aacaggcaga cgacgcagtg ctcgtagatt cctcggaaat gggaattgat caggttgtag
    12361 atgctattct tgatgtgtat aataagaaga tacagaaata acggtcaggc ggacagatta
    12421 tctgtttcag actacgctat ctgcccgtca actacctatc acctaaagtg gtgctgcatc
    12481 atagggtggt tgacagcacc ctttacagac aagatatact catctgtaac tgtaaacttc
    12541 ccatgctata cagcaaacat tcttttacgg gtaaggaaag gatttattta tgaaagttaa
    12601 agtagcagag acagcaggct tctgcttcgg cgtcaaacgg gcagtagaca aagtctacga
    12661 actgatcggc acagaacaga aaccaatcta cactctgggg ccgatcatcc acaatgaagg
    12721 tgtagtagcg gatctggaag cccgtggcgt ccatgttatc acagaagcag acctggattc
    12781 cccggatgac accctacaga acggaacagt agtcatccgc tctcacggtg taggcaaagc
    12841 catctacgat aagctgaaag aaaaaaacat ctcttatgta gatgtgacct gccccttcgt
    12901 tctgaaaatc cacaggatcg tggaaaaaga aagccttgca ggaaaccata tcatcatcat
    12961 cggcgacaaa gaccaccccg aagtacaggg catctgcggc tggtgtcagg gaccgtacac
    13021 ggtgatcaga aacaaagaag aagccgaagt atttgtaccc ccaaaaggca aaaaaataag
    13081 tattgtgtcc cagacgacat ttaag
//
