LOCUS       c00087_gnlPro..        14301 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BJEJHOAE_87.
ACCESSION   c00087_gnlPro..
VERSION     c00087_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 07:21:05
            Original ID  :: gnl|Prokka|BJEJHOAE_87
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 26887
            Orig. end    :: 41188
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14301
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[36887:41099](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(10001..14212)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14301
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14301
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             778..1788
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_24"
                     /sec_met_domain="ATP-grasp_3 (E-value: 6.9e-09, bitscore:
                     27.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIIVVSNSLSKRIEYFIEAGKHLQVEVRFMTYGELFNCLPQLRQ
                     AVIKLEPCVSDETNFLKYALLNQAYKETLQRLGEMRLSDDVCFLNTPHALLRALDKKET
                     KQVLMDRGLKVTPMLPSPRSFDELRELLADCGRGCFLKPRYGSGAGGIMAVRYQPNRNK
                     WVVYTTLQQVDGVIHNTKRINRLSTEKEMIPLAEAVMQTEAILEEWIPKEQLQGENYDL
                     RVVCRESEIDYIVVRCSKGSITNLHLNNKAHWWNELSLPEVVRQQIYFQCQEAVQSLDL
                     QYAGVDVLIERGTDIPYIIEVNGQGDHVYQDMFAHNSIYIQQIKNIKKRYNHANR"
     CDS             1775..2629
                     /locus_tag="ctg87_25"
                     /transl_table=11
                     /translation="MQIDELPAGEQTQNPDLDMNQVVGTHDILMLCFDTLRYDVSKEEE
                     EAGRTPVLNSHGGEWEKRHAPGNFTYPSHFAIFAGFLPSPAEPHSLRSRKWLFFPVQAG
                     TGRIPPAGSYPFTEATFVQSLANVGYETICIGGVNFFSKRNELGRVFPGYFTKSYWLPT
                     FGCTAPDSTEKQIDFALKKLENYPEDKRIFMYINFSAIHYPNCHYVEGKMKDDKESHAA
                     ALQYVDSQLPRLFQAFQKRGNTLVIALSDHGTCYGEDGYEYHCISHETVYTVPYKHFIL
                     TKK"
     CDS             2626..3903
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_26"
                     /sec_met_domain="Radical_SAM (E-value: 2.2e-16, bitscore:
                     51.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQPLPRYVDYMYSYPHKTAYRSFPSPVSLVPYLKQVEGQKASLY
                     FHIPFCSHKCGYCNLFSLQTNRADYIATYLETLHKQAQQLSPLTTGLAFDSFAIGGGTP
                     LLLTVPQLEYLLDTAALFGVHPSHTFTSVETSPEYADPTRLDLLKQAGVARVSIGVQSF
                     LDEELTALKRRPRRDMINQALEAIRKRQFPFFNIDLIYGIRGQTVASFLYSLEQALLFQ
                     PNELFIYPLYVRPGTAITERESDDVCFQMYCAACDLLKDRGFLQTSMRRFIHHPSTDAE
                     ISCGDEVMLSCGSGGRSYLGNLHYATRYTVCQRCIAGEIDDYMGTTDFTVARNGFILSQ
                     EERRQRFIIKNLMYYMGLDKAEYKRRFGESPDNVMLFRQLAERQWIENTDSGRICLTSD
                     GMAYSDYIGQLFITPEIRELMETYSY"
     CDS             3915..5480
                     /locus_tag="ctg87_27"
                     /transl_table=11
                     /translation="MENESSLLSFRHIYYRGKLNSCNYTCSYCPFGKKSHLADTTQDEQ
                     AWNRFIAAIEQWKGEPLQLFIIPYGEVLIHRYYRKGMVHLAALPQVAGISCQTNLSFPA
                     KHWLDEIRVAPTVISKIRLWASFHPEMTSVEKFAHQIHILHHAGIQVCVGAVGNPSAKV
                     VLNDLRNALLPDIYLFINAMQGLRAPLSQEDIQFFSQLDNLFEYDLKNAPVQWEVCAGG
                     RDNCFIDWKGDMYACPRSRVKIGNFYQGDGAVVPLSCKRKVCDCYIAFSNLNNHPLHRI
                     MGEGAFWRIPDKPLITTVFFDVDGTLTDSQGKVPESYANALRYMAQSVSLYLATSLSME
                     QAKKKLGKALFDLFRGGVFADGGLLSYSRQIKCLPVKVYPEVYGESSKVTIHSYEGVVY
                     KYSILVRDKEQRESILTRLKENPCQVFHKAPLITVIHPEASKKEGMLQLCKALGLASEH
                     TLVVGNSLKDWPMMSVVSHSCAVMNAEPLLKECARYTLNPDRLAAFFRFSNGDPIDQTS
                     SDNS"
     CDS             5717..7081
                     /locus_tag="ctg87_28"
                     /transl_table=11
                     /translation="MKELDLTQGSVPKVLLQFAVPFLIANVLQALYGGADLFVVGQYDD
                     SASVAAVAIGSQVMQTITGIILGITTGTTVLIAIATGAKDNRKVAFTIGSSVWLFSITG
                     VVLTLVMVLFHSRIAELMHTPVEAMVDTKNYILVCSLGILFIVGYNVVCGILRGLGDSK
                     TPLYFVGLACVINIVLDFILVGYFHWGATGAAIATVTAQGVSFGIALWFLYRHGFHFDF
                     SRKDIRLNRNLSKKILVLGAPIALQDALINVSFLIITVIVNQMGVIASASLGVVEKIIV
                     FAMLPPMAISSAVATMTAQNYGAGLIKRMNKCLASGIGIALVFGVSVCVYSQFLPETLT
                     AFFTKDAAVVAMAADYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRI
                     PLSYWFSQIDSSSLFIMGFAPPISTVVSLLICIWYLRYTQRKLYLRGTMMPAMSN"
     CDS             7122..7634
                     /locus_tag="ctg87_29"
                     /transl_table=11
                     /translation="MEAYLKKLCFEYQVDEREVKELLARMEMVYLDKGETIASATLPEQ
                     SLYIIVSGILHTYTTHEGEERTNRFFSAGDAVLCYNSSQYSIKTLTKCAAYYISEEEIE
                     ELCASSISFANLVRQLMEYQFYFKEEEDMNARKLTVRERYLSLLAEIPDILYRVPLKHI
                     NHYLGQM"
     CDS             7793..8671
                     /locus_tag="ctg87_30"
                     /transl_table=11
                     /translation="MKNSIPRYTFYKHKYGSELLVDVVELKYVKKFLAKSAVHTLNYYD
                     ITFITEGKGAFSVDNQTYEAIPRDVLFSKPGEIRNWDTHHITNGYALIFEEEFLSFLFK
                     DSLFVQHLSFFQIESSSSLLHLSDELYTRILETLHDIKVEIDSYQQGDVHVLRALLYEV
                     LMLLDRAYLKMTSIEEGRSREVSNNHVSKFMNLVATHAKEQHSVQYYADKLCITPNYLN
                     EMITSTMGISAKQYIQSKVMEEAKRLLVYTDFPIADIAFELCFSTVSYFIRSFRQHTGE
                     TPLLYRKVHKP"
     CDS             8764..9186
                     /locus_tag="ctg87_31"
                     /transl_table=11
                     /translation="MMRDAEKTVGNMIDKLKTAFIGSIDGEGFPTIKAMLQPRKRKGIK
                     TIYLTTNTSSMRVAQYRENNHACIYFCDTRFFRGVMLRGTMDVLTDSASKEMIWQEGDT
                     MYYPEGVTDPDYCVLKFTAISGRFYSNFKSEDFVVE"
     CDS             complement(9376..9996)
                     /locus_tag="ctg87_32"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEE"
     CDS             complement(10001..14212)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_33"
                     /sec_met_domain="HGD-D (E-value: 1.3e-22, bitscore: 72.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1e-33, bitscore:
                     108.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVYKVGLDIGSTTTKMVVLDKDGTTVLFSGYKRHQAKIQECLLG
                     FLYQIKEQLGDIPLSFHITGSVGMGISEKCSLPFVQEVVAATNYVCREHPHTATMIDIG
                     GEDAKVVFFQDGQATDLRMNGNCAGGTGAFIDQMAILLGVSIDELNELALRSNQVYSIA
                     SRCGVFCKTDIQNLIAKNISKENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTF
                     IPALRKAFANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSV
                     TSPFQSDLSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLD
                     NNHRILYSYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFH
                     MDAGIIETIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSF
                     ISTFAQSLDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSY
                     SVVKNCLYKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGAL
                     GCALYAKQIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNNDNHYFSGNRC
                     EKVFSNKGSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFT
                     ACGIQVQLSAPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTLQNVNRIFMPFVVFE
                     KKDKQQQNSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKDEALLYKQCYEYLKSLGIR
                     DEVCKNAFSRALQEQYAFEEKIAAYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVS
                     DMIAAMGVYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMTS
                     FGCGPDAFLIDEVRNLLKRYGKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQAK
                     DPEPFVSTAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGL
                     KYSNNEVCYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIEN
                     GYTNTPVVSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERG
                     QAARLRDLYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFN
                     PFAQKDVTSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKV
                     QKQINKVNEIGKNFNYFTPFESIFEKAEKAKQVISPGTQFGEGWLISGEILSFASQGVN
                     HVISLQPFGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNIN
                     N"
ORIGIN
        1 ttgaaagata aacatctctc tgaatataaa caaataacaa tcggttgttg ggattatgag
       61 ggtggcgact gttctgcctt attacaggga atgattgaaa ataaggagaa gttcgcacaa
      121 atagaaggct tgttctgggg agatattgag caggaagaac aggagatttc atggattgaa
      181 caagctgata ttagtccgct gctcgatgcc atgcctaaat tgaaagatct gaaaatcaaa
      241 ggaaccaata atctgcgttt gggaaagact tcacggccgg agttgcggtc actcgaaatt
      301 atcagtggtg gcctgcctac cgaagtggta gaagatattc ttggttctga tttccccaat
      361 ctggaaaaac tgattctata tgttggtgtg gaagattatg gatttgaagc tgatattgag
      421 atattccgtc cgttgttctc caaagaacgt ttcccgaagc tgacttatct ggggatcgtc
      481 aactctgaag aacaggacaa gattgtagaa atgttcctgg agtcggatat tcttccccaa
      541 cttgaaacaa tggatgtttc ggctggtact ctcaaagatg aaggtgccca attattgctg
      601 gataatatgg ataagatcgc tcatttgaag tttatcaata tgcgctataa ttatttgagc
      661 aaggagatga agaaacagtt gcagagtctc cctatgaaaa tagatattgc tgaaactgaa
      721 gaggcagatg aatatgatgg tgaattgtgg tattacccga tgattacaga ataggagatg
      781 cagataatcg ttgtcagcaa ctctctgtcc aaacgtatag aatactttat tgaagcaggc
      841 aaacacttgc aggtggaagt tcgttttatg acttacgggg aactttttaa ctgcttgccg
      901 caactacggc aggcagttat caaactggaa ccttgtgtaa gcgatgaaac gaatttcctg
      961 aaatatgcgc tgttgaatca ggcatataag gagacactgc aacgtttagg cgagatgagg
     1021 ctatctgatg acgtgtgctt tttgaatact ccccatgctt tattacgtgc tcttgataaa
     1081 aaggaaacta aacaagtgtt gatggacaga gggttgaaag tgactccgat gttaccttct
     1141 ccccgttctt ttgatgagtt gagagagctt cttgccgatt gcggtagagg atgctttttg
     1201 aaaccccgtt acggttcggg ggcgggaggt attatggctg ttcgctatca acccaaccgg
     1261 aataaatggg tagtctatac taccttgcaa caagtggatg gagtcattca taacactaaa
     1321 cgtatcaacc gtttgagtac ggaaaaagag atgatcccgt tggcggaagc tgtgatgcaa
     1381 acagaagcta ttttagaaga atggattcct aaagagcagt tgcagggaga gaattatgat
     1441 cttcgtgtag tgtgccggga atctgaaatt gattatatcg ttgtgagatg cagtaaagga
     1501 agcataacca atctgcatct gaacaataag gcacattggt ggaacgaatt gtctttgccg
     1561 gaagtagtgc ggcaacaaat ctattttcag tgtcaggaag cggttcaatc tttggatttg
     1621 caatatgccg gagtggatgt actgatagag agaggaacag atattcctta tataatagaa
     1681 gtcaacggac agggagatca tgtgtatcag gatatgtttg ctcataattc tatttatatt
     1741 caacagataa aaaacataaa aaagagatat aaccatgcaa atagatgaac tgccggctgg
     1801 cgaacagacc caaaatccgg atctggatat gaatcaggtg gtgggtactc atgatatatt
     1861 gatgctttgc tttgatacct tgcgttatga tgtcagcaag gaggaagaag aggcaggaag
     1921 aacaccggta ctgaacagtc acggaggaga atgggaaaaa agacatgcgc cgggaaattt
     1981 tacttacccg tctcattttg ccatctttgc aggatttctg ccttctccgg cggaacctca
     2041 ttcgctacgc agccgtaagt ggttgttttt ccctgtgcaa gctggtacgg gacgtattcc
     2101 gcctgcggga agttatccgt ttacggaagc aacttttgtg caaagccttg ccaatgtagg
     2161 ctatgaaacg atttgtatag gaggggtgaa cttcttcagc aagcgtaatg aactggggcg
     2221 tgtgtttccc ggttacttta ctaaaagtta ttggctgccg acctttggat gcacggcacc
     2281 cgatagtact gaaaaacaaa ttgattttgc attgaagaaa ctcgaaaact atccggagga
     2341 caaacggatt tttatgtata tcaatttttc tgctattcat tatccgaact gtcattatgt
     2401 ggaaggcaaa atgaaggatg ataaggaatc acacgctgcc gcgctgcaat atgtcgacag
     2461 tcagctaccc cgtttatttc aggcctttca gaagcgggga aatacgctgg tgattgctct
     2521 ttccgatcat ggcacttgct atggagagga tggatatgaa tatcattgca tatctcacga
     2581 aacggtttat acagtccctt acaaacactt tattttaacg aaaaaatgaa tcaaccgcta
     2641 ccacgatatg tagactatat gtatagttat ccacataaaa ctgcttatcg ttcttttccg
     2701 tccccggttt cgctggttcc ttacctgaaa caggtggaag gacagaaagc atcgctttat
     2761 ttccatattc ctttttgtag tcataaatgt ggatattgca acctgttttc tctgcaaaca
     2821 aatcgtgcgg attatatcgc aacttatttg gaaactcttc acaagcaggc gcaacagttg
     2881 tctccactca ctaccggact ggcatttgat agtttcgcca ttggaggagg cacaccgttg
     2941 ctcctcactg ttcctcaact ggaataccta ttggatacgg ctgccttatt cggagtgcat
     3001 ccttcacata cctttacttc cgtagaaaca tcgccggaat atgccgatcc tacccgtttg
     3061 gacttgttga agcaagcagg agtagctcgt gtgagtattg gcgtacagag tttccttgac
     3121 gaagaattaa cagctttgaa aagacgtccc cggcgagaca tgattaatca ggcgctggag
     3181 gctattcgga agagacaatt cccgtttttt aatattgatt tgatttacgg aatcagagga
     3241 caaactgtgg ccagctttct ttattcattg gaacaggctc ttctgtttca gcctaacgaa
     3301 ctctttatct atccgctata tgtacgaccg ggaacggcta tcacggagcg ggaatccgac
     3361 gatgtctgtt ttcagatgta ttgtgccgct tgtgatttgt tgaaagacag aggttttcta
     3421 caaacgtcga tgcgacgttt tattcatcat ccgtctactg atgcggaaat ctcatgtggg
     3481 gatgaagtga tgctgtcgtg tggctccggc ggacgcagtt acctgggtaa tttgcattat
     3541 gccacccggt atactgtttg ccagcgttgt attgccggag agatagatga ttatatgggc
     3601 actactgatt ttacagtggc tcgtaatgga tttattcttt ctcaggaaga acggcgacaa
     3661 cgtttcatca ttaaaaatct gatgtattat atggggcttg ataaggccga atataagcgt
     3721 cgctttggag aatcaccgga taatgtgatg ttgtttcgac agttagctga acggcaatgg
     3781 atagaaaata cggatagcgg tcgtatttgt ctgacttccg acggaatggc atactccgat
     3841 tatattggtc agttgttcat tactcctgaa ataagagaac tgatggaaac ttattcttat
     3901 tgaacgaaat agaaatggaa aacgaaagct ctttactttc cttcaggcat atatattatc
     3961 gcggcaaatt gaatagctgc aactatacct gttcttattg tcctttcggc aagaagtcgc
     4021 atctggcaga tacgacacag gatgaacagg catggaatcg ttttatagca gctattgaac
     4081 aatggaaagg ggagccgttg cagttattta ttattcctta cggtgaagta ttgatccatc
     4141 gttattatcg gaaaggaatg gtgcatttgg cggcattgcc acaggtggcc ggaatttcct
     4201 gtcagactaa cctttctttt ccggctaaac actggcttga tgagattcgt gtggctccca
     4261 ctgtgataag taagataagg ctttgggcta gttttcatcc tgagatgact tcggtagaga
     4321 aatttgcgca tcagattcat atactccatc atgcgggaat acaggtatgt gtcggagcgg
     4381 taggaaatcc ctctgcaaag gtcgtactca atgatttacg gaatgctctt ttgccggata
     4441 tttatttatt cattaatgct atgcaagggt taagggcacc attaagtcag gaagatattc
     4501 agtttttcag tcaactggat aatctttttg agtatgactt gaagaatgct ccggtacaat
     4561 gggaagtttg cgcaggagga agggataatt gttttatcga ttggaaaggg gatatgtatg
     4621 cttgtccccg aagccgggtg aagataggta atttttatca aggtgatgga gctgttgtgc
     4681 cgttatcttg caagaggaag gtttgtgact gttatattgc atttagtaac ctgaacaatc
     4741 accctttaca tcgaataatg ggagaagggg cattctggcg aataccggac aagccactta
     4801 ttacgactgt tttcttcgat gtggatggaa cactgactga ttcacaggga aaagttccag
     4861 aaagttatgc taacgctttg cgatatatgg cacagtccgt ttccttatat cttgccactt
     4921 ctctgtcgat ggagcaggcg aagaaaaagc tgggaaaggc tctttttgat ttattcaggg
     4981 gaggagtgtt tgcagatgga ggtttattat cttattcgcg gcagattaag tgtttgccgg
     5041 tgaaagtata tccggaggta tatggagaat cgtcaaaagt tactattcat agttatgaag
     5101 gagtggttta caagtatagt atattggtac gtgataaaga acagagagaa tctattctta
     5161 cccggttgaa agaaaatccc tgccaggtct ttcataaagc tccgctgata acagtcattc
     5221 atcctgaagc gagtaaaaaa gaggggatgc ttcagttatg taaggctttg ggtttagctt
     5281 ctgaacacac tttagttgta ggaaattcgt taaaggactg gccgatgatg tccgtggttt
     5341 ctcattcttg tgccgtaatg aatgcggaac ccttattaaa agaatgcgca cgttatacgc
     5401 tgaatccgga tcggttggca gctttctttc gtttttctaa cggagatcct atagaccaaa
     5461 cctcgtctga taatagttga tatatagcta gttacatctt cataagaaaa taaaaaccgg
     5521 ttaaaatttg gtaattatga aaacaaagcc catatttgca gccctgaaat agggacaggc
     5581 ataaaaatcc tcatcggagg gtgctataat aataattata gtgctggata agatgaatgg
     5641 tgcaaatcat tcgcttgtcc ggcacttttt tttgttgtaa caaaataaga taaagaggaa
     5701 aagtatcgaa gaaactatga aagagttaga tttgacacaa ggaagcgtac cgaaggtatt
     5761 gttgcagttt gcagtacctt ttctgattgc caatgtgctc caggcacttt atggcggagc
     5821 tgaccttttc gttgtcggac aatatgatga ttcggcaagt gtggcagccg tagctattgg
     5881 tagtcaggtg atgcagacaa ttacaggtat tattctgggt attactaccg ggacaacagt
     5941 gctgattgct attgctaccg gagctaaaga caatcgaaaa gtagctttta ctatcgggtc
     6001 ttccgtatgg ttgttttcaa taaccggcgt agtgctaact ttggtcatgg tgctttttca
     6061 tagtcggata gcagaactga tgcatactcc tgtcgaagcg atggtagata cgaaaaacta
     6121 tattttggta tgctctctgg gtattctgtt tatagtagga tataatgttg tatgtggtat
     6181 tttgcgtgga ttgggtgatt ctaaaacacc actttatttt gttgggctgg catgtgtgat
     6241 aaatatagtg ctcgatttta tattggtcgg ttatttccat tggggggcta cgggagcggc
     6301 tatcgctact gtaactgcac aaggagtcag ctttggaata gcgctctggt tcttataccg
     6361 gcacggattc cattttgact tttcacggaa agatattcga ttgaaccgga atctgtctaa
     6421 aaagatcttg gtgttgggag cacctattgc tttgcaggat gctttaatca atgtttcttt
     6481 tctgattatc actgtcattg tcaatcagat gggagtcatt gcatctgctt ccctgggtgt
     6541 tgttgagaaa atcatcgtgt ttgctatgct gcctccgatg gctatatcat cggctgtggc
     6601 aaccatgact gcacagaact atggagcggg acttatcaag agaatgaata aatgtctggc
     6661 ttcggggatt gggattgctc ttgttttcgg tgtgtcggtt tgcgtgtatt cgcaattcct
     6721 gccggagact cttactgctt tctttacgaa agatgctgct gtggtggcaa tggcggcaga
     6781 ttatttgcga gggtatagca tcgactgcat cgtggttagt ttcgtgttct gcattaattc
     6841 ttatttcagc ggacaaggaa actcgttatt cccgatgatt cacagtctga tagccacttt
     6901 cctgttccgt ataccgttgt catactggtt cagccagata gatagctcgt cgctgtttat
     6961 catgggattt gctccaccca tttcaacggt cgtttcatta ttgatctgta tctggtattt
     7021 acgatatacc caaaggaaat tatatttgag aggcacaatg atgcctgcta tgtcgaatta
     7081 ggtgttttta agtgacatat attaactaaa atctattttg tatggaagct tatttgaaga
     7141 aactctgttt tgagtatcag gtggatgaaa gagaagtgaa agagctgttg gctcgaatgg
     7201 aaatggtgta tctggataaa ggagaaacga ttgcttctgc cacattgcca gaacagagct
     7261 tgtacattat tgtttccggt attttgcata catataccac tcatgaagga gaagagagaa
     7321 ccaatcggtt tttctctgcg ggtgatgctg tgttatgcta taattcaagt cagtattcta
     7381 tcaagacact gacgaaatgt gctgcttatt acatcagtga agaggagatt gaagagttgt
     7441 gtgcatcttc aatttcattt gcgaatctgg tccgtcaact gatggagtat cagttttact
     7501 ttaaagagga agaggatatg aatgcccgca agctgacagt aagggaaagg tacctctctt
     7561 tattggcgga aattccggat attctgtaca gggtgccatt gaagcacatt aatcattact
     7621 tggggcagat gtgaccagtt tgggatatct ggccggaagt tctaaatagg aaatataacc
     7681 tagacatatt tttctatgta ttccttatca gatggttcat ggcttattca atcgaatcga
     7741 atttgaaaag tctttggatt atttggtaag gaatactatt tttgtattct gaatgaaaaa
     7801 ctcaatacct cgatatactt tttataagca taagtatggg agtgaacttt tggtcgatgt
     7861 agtagaactg aagtatgtga agaagttcct ggctaaaagt gctgtccaca ctctaaatta
     7921 ttatgatatt acttttataa cagaaggtaa gggagctttt tcagtcgata accaaaccta
     7981 tgaagcaatt cctcgtgacg ttcttttctc taaaccgggg gaaatccgga actgggatac
     8041 tcatcatatc accaatgggt atgctctgat tttcgaagaa gaatttttgt ctttcctctt
     8101 taaagattct ttgtttgtac agcatctttc gttttttcag atagaaagtt cttcatcgct
     8161 actacatttg tctgatgagc tttatacacg catacttgaa accttgcatg atataaaggt
     8221 ggagattgat tcgtatcaac agggcgatgt acacgttttg agagcattgc tttatgaagt
     8281 cctgatgttg ctggaccgtg cttaccttaa aatgacttcg atagaggagg gcagaagtag
     8341 ggaagtttcc aataatcatg taagtaaatt catgaatttg gttgctacac atgcaaaaga
     8401 gcaacattcg gttcaatatt atgcggataa gctctgcatt actcctaatt atctgaatga
     8461 gatgataacc tcgaccatgg gaatcagcgc aaaacaatat attcagagca aggtgatgga
     8521 agaggctaag aggctgcttg tttatacgga ctttcctata gctgatattg catttgaact
     8581 ctgtttttca acggtttctt attttatccg tagcttccgg cagcatacgg gagaaactcc
     8641 gttattgtat cgtaaagtac acaaaccgta aaaagtgcta tttctacctt tctttttatt
     8701 gcattgcttt cctggcattt ctctactttc gcatcagata ataaaccaat aataaaaagt
     8761 aaaatgatga gagacgcgga aaaaacagta ggcaacatga ttgataagct gaaaacagct
     8821 tttatcggtt cgatagacgg tgaaggattt cctaccatca aagcaatgct gcaacccaga
     8881 aaaagaaagg ggataaaaac tatttatctg acaacaaata cttcgtccat gcgtgtggcg
     8941 caataccgtg agaacaacca tgcgtgtatc tacttctgtg atacgagatt ctttagaggt
     9001 gtcatgctac gcggtacgat ggatgtcttg acggatagtg ccagtaaaga gatgatctgg
     9061 caggagggag ataccatgta ttatccggag ggagtgacgg atcccgatta ctgtgtattg
     9121 aagtttactg ctatttcagg acgtttctat agtaatttta aatcggaaga ttttgtggtc
     9181 gaataaggtg caagatgggg tgattggaat ggtaataacg gagtgtgtca aaacgcagat
     9241 taacgcaaat tatcgcagaa ataattttat aagtcgttga ttaatatatc aatataattg
     9301 gaataatctg cgataatttg cgttaatctg cgttttatta ttcattatga cacacctcct
     9361 tatatagtat ctatactatt cctcataaca caataagttc tgcaattggt tgatgatgtt
     9421 ttgtttccat tcttgcagga agtcagcaaa agcggcttca tcttccaaga ataaagatac
     9481 tatcaggttc ttggcaagaa atggatagct caataggctg tagacagtca gaaatacaat
     9541 atgtatcgga acctttttaa gtttaccgtc ttccattgct gtcagtatac tgtctttcac
     9601 ttgggataaa gcatctccga actgaagttc ttttgcagtg gcaagcaagt ggtttacatc
     9661 acgctgtatt tctccgcaaa tgaatctggg aagacaggga ttacttgtga aaagctcaat
     9721 atactcatcc agaatcatgc ttagtcgctc cataaatggg atatcctgtt ttactatatc
     9781 ctgtattttc ggcattaaag acatgactat cgagccgaac acggctttga acatcttatc
     9841 tttggttctg aaataataat gtaaagtggg ccggttgatt cctaccgttg cagcaatatc
     9901 actcatgctg gtctccacaa atcctttttc tataaaaagt tgttgggcag tttttattat
     9961 ttgctgctct aaatcgctat gttccgttgt agccataatt ttagttgttt atgttgtcaa
    10021 taaaaagtaa taatctgttt gttatgttca catcgctgac gctactgtca aagtctaaag
    10081 atagtatatt catttgaggg cacagcgatt ttatacgttt ttctattcct ttttctacaa
    10141 tgtgattggc aatgcatccg aaaggttgca agctaatgac atgattgact ccttgggaag
    10201 caaaggatag tatttcaccg gatatcagcc aaccctctcc aaactgggtg cccggggaga
    10261 tgacttgttt agctttttct gccttttcaa agattgattc gaacggcgtg aagtaattga
    10321 aatttttgcc gatttcattc actttattaa tctgcttctg gactttcttg tataaccagt
    10381 cgataacaaa gtcgggagtg agttttcgct gcaagtgttg gttctgtctc actttcaggt
    10441 tgacaaatcc ctgcatgaag aaatcactta tcagtggcgg aatcacttcg atcttctggt
    10501 tgatgagcca tgaggtgacg tccttttgag caaaagggtt gaacttcagg aatatttctc
    10561 caacaatacc tactttgtga caggatctct gttcacagat tttgttgaag tctctggcag
    10621 cgagatataa gtaactcaac aagtcctccg gtttattttt ctggatgatg ggctgtgctg
    10681 tatccagata aagatcgcgc agacgggcgg cctgtccccg ttctttctca cgaacgacgg
    10741 ctgcataata gaatttagcg atacaatcac tgtataacac agacgcaagt atgattggca
    10801 aaaccttgag ccagtttact ttaaaaccgg attgctcatt ttcaatacca ctgccgaaag
    10861 caagtgatac caccggtgta ttggtgtatc cattctcaat caatgccttt tttatcagtg
    10921 aaatatagtt gctggcacga cattgtccac cggtttgtgt gatggcaacg cacgtattgg
    10981 caggatcata acgtccgctt ttaaaggctt ttactatgtc gccgacaatc aatgttgccg
    11041 gataacatac ctcattattg gagtatttca atccccagtc gcaagatgcg gtgtcgctca
    11101 acggtaacgt ttccatttca tatccggcca ctttcatgat ggatggaatg agtggtgaaa
    11161 tgaaaggcgt aaagaatgga gcgaggattt tcttcttttt gtctttcttg gtgaaaggag
    11221 cagttgaaac aaatggctcg ggatctttcg cttgagaatg tttcaaactg aaattcaagc
    11281 tttccaccaa cgagcggact cgtaatttga tggagccgat attattaaca tcgtctatct
    11341 tgagcaaagt aagattcttg ccgtatcgtt tcagcaagtt acgtacttca tctataagga
    11401 aagcatccgg accgcagcca aaagaagtca tctgcatata ttgtatgtca ccctcttgca
    11461 ttgccgccca cttggttgct ttcagaatac ggttggtaaa tgcccattga gagaggtaat
    11521 gagtcttttc caatgaaatc tcctgctggc ggacaatatc atcagttatc acataaactc
    11581 ccatcgcagc aatcatgtcc gaaaccttgt gctgtatcag tggatcgcta tggtaagggc
    11641 gtccggcgag taagataatc agtttgtgtt tttcccgtcc ctcgttcaga acttcctgat
    11701 tataggcagc aattttttct tcgaaagcat attgttcctg taatgcgcgt gagaaggcat
    11761 ttttgcatac ctcatccctg atacccaaag atttcagata ttcatagcat tgtttataca
    11821 gcaatgcttc atctttgaag gtgatagtcg gagcatctat cggtatattc tcttcctgta
    11881 cacttttgat gacttccgaa taaccggaaa cgatggggca attatagctg ttttgctgtt
    11941 gcttatcctt tttctcgaaa acaacgaacg gcataaatat ccggttgacg ttttgcagtg
    12001 tcaggttacg gatatgactg tgcacaagtt tggcagggaa gcagatgtta tcagacatca
    12061 ccatgccggc agcagtctcg tatttgctga atgtagaggg ggccgacaac tgtacctgaa
    12121 tgccgcaagc agtaaataag gtatgccaga aagggtattc ctcatacata ttcagaatac
    12181 gtggaatgcc tatggtaaat aggggttgtg gaatgtctgc gctccggtcg aataataatt
    12241 ccagcttttt atcatacgta ttgatgcctt tgtccgcatg gcttccttta ttggaaaata
    12301 ccttttcaca tcggttgccg gagaagtaat ggttgtcatt gttgaacgta tatcgcataa
    12361 tggcgcactg gttctcgcac ccccggcatt gaagttgctt ggaagtatat tgcgcccatt
    12421 ggagcatctc gttcagctcc gtcacccggg cattttcgat ttgtttggca tatagggcac
    12481 aaccaagagc acccatcaat tcaggacagt tactgcggaa ggtttgtttc ccggtcagct
    12541 tttccagact tcgtacgatg gaatcattac gcatggttcc tccctgcacg acaatatggt
    12601 cgccaagtat ctccgtgtct tttaattgca gaaccttata caggcagttt ttaacaacgg
    12661 aataagataa tccggcagct atatccgcta cggacgctcc ttcccgaagt acctgtttta
    12721 ctttggagtt catgaagact gtgcaacgtg tacccagatc acatggtgct tgcgaaaaac
    12781 aagctgcttt ggcaaagtcc tccacactgt aatccagcga ttgcgcaaat gtgctgataa
    12841 aagaaccgca accggaggaa caggcttcat tgatttcgat tctgttgatt actccgtcgt
    12901 tcacaaagat ggctttcata tcctgccctc caatatccag gataaaagaa acttctttgc
    12961 tgatatgttt ggcagcagca taatgagcga tggtttcaat gattcccgca tccatgtgga
    13021 aagccgcttt tatcagatct tctccgtaac cggtagaaca tcctcctttt atgcgcaggg
    13081 tagttcctcg tctccggcat tcttcatata gtttctgcaa gccgttctct actgttttta
    13141 tagggtttcc gttgttgtcg tgataatagg agtaaaggat acgatgattg ttgtcgagta
    13201 ctacgatttt ggtggtagta gagccggagt ctatgccgat agttgcttcc tgtaatccgg
    13261 gacgcagact ggcatattga attttatact ggtctttttc ttttttccat gaccgatatt
    13321 cttcctcact gtcgaatata ggagaaagat cactctggaa aggtgaggta acacttagtt
    13381 tgttttctat tacctgtatc aggttggaga gatgaatact ttcttcattg ttctctgcca
    13441 atgctgctcc ccaggcaggg atcagatttc ctttttccgg taatatgaaa tctgtatctt
    13501 gtgacagatt cagatagttg gcaaatgctt ttcgaagggc cggaataaaa gtcaatgggc
    13561 caccgcagag taataccgga gctacgatat tgcaaccgcg tgcaagtgtg acagtggtct
    13621 gtacggctac tgcatggaaa atggaagctg ctatattttc tttagatata tttttggcta
    13681 tcagattctg tatgtccgtt ttgcagaata ctccgcagcg tgaagcgata gagtatacct
    13741 gattggaacg aagtgctagt tcattcaatt cgtcgatgga gactccaagc agaatagcca
    13801 tctggtcaat gaaagccccg gttccgccgg cgcaatttcc attcatgcgc aggtctgtag
    13861 cctgtccgtc ctgaaagaaa acaactttcg catcttctcc tccaatatcg atcatagtgg
    13921 ctgtgtgcgg atgctcccgg cacacatagt ttgttgcagc tacaacctct tgcacaaacg
    13981 gcagagagca tttctctgaa attcccattc caacagagcc cgtaatgtgg aaagataaag
    14041 gaatatcacc caactgttcc tttatttgat aaagaaatcc gagtaaacat tcttgtattt
    14101 ttgcctgatg ccttttgtat ccggaaaaca agactgtagt tccatcttta tccaatacta
    14161 ccatcttagt ggtagtagag cctatatcta aacccacttt atatacattc atataccaaa
    14221 tatcccttaa ttccgcaaca ctataattta actttattta taagttcctg agcaacaaaa
    14281 agttgcccag gattttgcca t
//
