LOCUS       c00014_gnlPro..        16665 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GCHHHCKP_14.
ACCESSION   c00014_gnlPro..
VERSION     c00014_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 05:21:32
            Original ID  :: gnl|Prokka|GCHHHCKP_14
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 48961
            Orig. end    :: 65626
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16665
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[58961:64569]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15608
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16665
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16665
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             1816..2346
                     /locus_tag="ctg14_42"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGNET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIDEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
     CDS             2599..4017
                     /locus_tag="ctg14_43"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVQPGGHILVDDGLVDLEVQDIAGKDIVCKVINAGVIGDKKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILSVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             4186..4872
                     /locus_tag="ctg14_44"
                     /transl_table=11
                     /translation="MKTNEEEDSRHIFRGELALVIAVMINSLAVILMLYSGSGISAISS
                     VPYAFEKVFPVITLGTWTYIFQALLILSLMILRKKFVPAYLCSFLVGFAFSELLDVNEA
                     WINILPKTIPLRVLYFVISYLLICIGIALSNRCGLPIIPTDLFPRELSEIIKVKYSKIK
                     VSFDVICLMITACMTGLILGHINGLGIGTVMAAFTMGKVIGLIGDEMDKHFRFVNFTQH
                     CSLHVQ"
     CDS             5008..5205
                     /locus_tag="ctg14_45"
                     /transl_table=11
                     /translation="MQIMKRLLIKNKRKLWLWFLLLVFLFLACRAAYITGSKAEQTRNN
                     EVEERQADSRSIPNEMEILC"
     CDS             5199..5963
                     /locus_tag="ctg14_46"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMNKLENSRVAVFGIGGVGGYVCEALVRSG
                     VGTFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGATHKCTER
                     RDIPGSVAFVPSVVGLIIAGEVIKDLTAEYRR"
     CDS             6304..7488
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.3; E-value: 1.8e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg14_47"
                     /sec_met_domain="MFS_1 (E-value: 1.6e-24, bitscore: 78.3,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGILFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLRKYD"
     CDS             complement(7901..8866)
                     /locus_tag="ctg14_48"
                     /transl_table=11
                     /translation="MSLLKEISITDLSNLRIGHASDYNAQTGVTVLYFPLGAKVGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDARTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVGNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSRIQDEEFLKYV"
     CDS             complement(8991..9626)
                     /locus_tag="ctg14_49"
                     /transl_table=11
                     /translation="MNTTTTTTTAATKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPG
                     LSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIV
                     CIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYIQ
                     GIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             complement(10001..10297)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_50"
                     /sec_met_domain="ALS_ss_C (E-value: 3.3e-23, bitscore:
                     73.6, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEVIKVIDFTDVFVRMKEILYIKVFNCSREDKAELFQIAETFQA
                     KVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIESISMMER"
     CDS             complement(10562..11275)
                     /locus_tag="ctg14_51"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             12038..13294
                     /locus_tag="ctg14_52"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKGKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKTEEP"
     CDS             complement(13363..13872)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_53"
                     /sec_met_domain="ALS_ss_C (E-value: 2.4e-22, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(13890..15608)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_54"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.6e-48, bitscore:
                     155.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             16544..16663
                     /locus_tag="ctg14_55"
                     /transl_table=11
                     /translation="LSKYYSIHEFSKIIGVSAQTLRNWDANGKLHPHHTTVSGY"
ORIGIN
        1 attaatgccg atcagcagtc ttccatcaga ctatggcatc ggatgttttt caaaaagtgc
       61 atatgaattt gtagactggt taaaggaagc cggacagact tactggcaga ttctgccatt
      121 gggaccgacc agctatggag attctccata tcagtctttc tctacatttg caggtaatcc
      181 atattttatt gatctggata cacttgtgga agaaggagtt cttgataaga aagactgcga
      241 gaaagttaac tggggaaaga agcctgacga ggtagattat gaaaaaatct acaagggccg
      301 atatccgctt ctgagaaaag catacgagaa cagtgatatc agcaagaatc ctgactatca
      361 gaaattcgta gcagagaaca gctggtggct gtcagattat gctctgttta tggcagtaaa
      421 agaccgtttc gaaggtgtag aatggaccaa atgggctgag gatatcagac tccgctggaa
      481 caatgccatg gattattatc gtgaagaact ctattttgat attgaattcc agcagtatat
      541 gcagtttaag ttctatgagc agtggatgaa actgaaatcc tatgcaaatt caaaaggaat
      601 ccagatcatt ggagatattc cgatttatgt tgcaatggac agtgctgatg catgggcgca
      661 tccggagctg ttccagctgg atcaggataa tgtaccactg gcagtagcag gatgccctcc
      721 ggatggattt tctgcaaccg gtcagttatg gggaaatccg ttatatcgct gggattatca
      781 cagaaataca ggatatcagt ggtggatttc cagaatgagt tattgcttca gactgtatga
      841 tgttgtgcga atcgatcatt tccgtggatt tgatgaatat ttctctattc catacggaga
      901 taaagatgca agaggcggac actgggaaaa gggtcccgga attgatctgt tccgtaagat
      961 cgaacaggcg cttggatgga agcaggttat tgcagaggac ttaggatata tgacagattc
     1021 tgtacgtcat ctggtatatg agagcggctt cccgggaatg aaggttctgg aatttgcgtt
     1081 tgactccaga gattccggat gtgccagtga ttatctgcca cataattatc cggagaactg
     1141 cgtggcatat acaggaaccc atgataatga aactatcgtg ggatggtgga agagcatcac
     1201 agcagctgag agaaaactgg cgagagatta tctgtgtgat catgcaacac cggaagaaga
     1261 actgtataaa tgtttcatta gtctgatcat gcgcagtgct gcgcgtgtct gcgttatccc
     1321 aatgcaggac tatatgggac tggacaacag attccgaatg aataaaccat ctacagttgg
     1381 tacgaactgg aagtggagaa tcaagaagag agatcttaca aagaaactcc agaaggaaat
     1441 atatgatgtg acacttcgtt acggacgtaa gaactgggat taaatacata atgaaataat
     1501 tggaataatg acagcgtttc ggatataaat aatattcgga acgctgtttt ttttaaccga
     1561 atcaagcagt tatttggtta aaaaagcaac gaagtggttg gttttatctg ttttgtttta
     1621 tccagtcaga gttatttgtc agagggagaa aaaaaggaca gtttcgcaag ctctttattt
     1681 ttgtatgaaa aagaaaacat tgaaattgtt ttggcgggcg tacaattgaa aaagaaatgc
     1741 attgattttc gggcaatgtc tgataaaata ttaaccagaa aaagcaaaag gacagatttt
     1801 caggagggaa aataaatgaa ctataacaga ttagaaacca gtctgatcga tgtgatcaaa
     1861 gaggaacagg cgaagcttgg atatatgaag gagaagatca gcctttatta tccgctcagt
     1921 tccctgaatc atttctttgg caatgagacg gatgctgcag gcatgatgga gattttaaaa
     1981 gattttcctt cttatataga agagaaattt ggcgaagtag cagtatcaca cagaggagat
     2041 cgtttctgct tcactgtttc ggaaaaagct tccgaatatg tacataataa tatgaaagag
     2101 aatgaattca tcaaggcatt gatcgaactg gttggcagac atggatgtac gatagatgaa
     2161 attaaagaac tgttccattc ttattcagat aaaatcatta ctgaaccaat ggataacgag
     2221 gagtttgatg tgatgatccg ctttgatgac ggatcagatc cttattatta ttgttttaaa
     2281 gatgaaggat gccatatcat ttaccacaga tttctgccgg aagactatgc agattttgga
     2341 ttctgataag aatgagtgaa aattttccaa ctgtcggatc agtaaaaata tatgtgatat
     2401 ttgcaacaaa agtatgttat ttttttgtca aatatcaaca aaaataagtc gaaattctat
     2461 attgacagat agtctcaata atggtaattt ttatttgatt taatgttttc atttatagaa
     2521 acaggtaaca ttttattaca ttattttaca ggaataaaat agataaaatt gagttgacag
     2581 tttggaggga aagattaaat gagaaaaacc aaaattatct gtacaatggg accgtctact
     2641 gataagggcg atgttatgga gcagcttgtg agagagggaa tggacgtagc acgttttaac
     2701 ttctcacatg gacctcacga tgagcagaga ggccgtatcc agaaactgag agaacttcgc
     2761 aagaaatatg acagacctgt tgcagcactt cttgatacaa agggaccgga gattagactt
     2821 ggatgcttca aggatggcaa ggtttctctg gaagaaggac agatttttac atttacaaat
     2881 aaagatattg aaggaactaa tgagtgcgta agcattactt ataaagagct ttataaggat
     2941 gtgcagccgg gcggacatat tctggttgat gatggacttg tagacctgga ggttcaggac
     3001 atcgcaggaa aggacattgt ctgcaaggtt attaatgcag gtgtgattgg cgacaagaag
     3061 ggtgtcaatg ttccgggtgc aaacctgaag atgccattta tcagtaagaa agatcatgat
     3121 gatcttctct tcggtatcca ggaaggattt gatttcgttg cagcatcctt tacacgtact
     3181 gcaaacgata tccgcgaagt aagaaaaatc ctgaaagaaa acggcggtga agagatccag
     3241 atcattgcaa agattgagaa ccagcagggc gttgacaata tcgacgagat tattgaagca
     3301 gcagatggca tcatgatcgc cagaggtgac atgggtgttg agattccgcc ggaatatgta
     3361 cctgttatcc agcagaaaat catccagaaa gtttacacag caggaaaacc ggttattaca
     3421 gcaacacaga tgcttgactc catgatctct catccgagac caacacgtgc agaggctaca
     3481 gacgttgcca atgcgatttt ccagggaaca agtgctacca tgctttccgg agaaacagca
     3541 gcaggtaaat atccggtaca ggcacttcag atgatgagcc gcattgcaga acatatggaa
     3601 cagaatattg attacaatac aatctttaag aaaacagaca gaaatgagaa tccggatatt
     3661 acaaatgcaa tcgcacatgc aacctgcctg acagcaatcg acctgaaggc cagtgcaatc
     3721 ctttcagtga caaaatccgg aagtacagct catatgatgt ccaaacacag accaggatgt
     3781 ctgatcggtg catgtacaag ctctgagaga gttcttcgcc agctgaatct gtcctggggt
     3841 gtttacccga tgctgatcaa agaagaatac agttctgaga tcctttgcct gagagcaatc
     3901 gaggcagcac agaagcataa acttgtaaaa gttggtgaca ctattgtatt tgccggtggt
     3961 gtaccgcttg gaattccggg aagaacaaac ctgatccgcg tctgcacggt tgagtaagtc
     4021 aggaaaatat cagtagttga agtgggaaac ttgcctgatt cgataaaaaa tagtattttc
     4081 agaaaatata agatgtaaaa gacacagggg tctgccgtca gaaaagtatg acagaaaata
     4141 ttttctgaca gcagtccctt gcttgtgtta gaggagagaa ttgttatgaa aacaaatgag
     4201 gaagaagatt cgagacatat tttcagagga gagctggcat tggtgatagc agtcatgatc
     4261 aacagtcttg ctgttattct gatgctgtat tctggttcag gaatatctgc catatccagt
     4321 gttccttatg catttgaaaa agtatttccg gtaattacac tgggaacatg gacttatatt
     4381 tttcaggcac ttctgatctt aagtctgatg atactgagaa aaaaatttgt acctgcttat
     4441 ctgtgcagtt ttctggttgg atttgcattc agtgagcttt tggatgttaa tgaggcatgg
     4501 atcaatatcc tgccaaagac aattccactc agagtgttat attttgtgat cagttatctg
     4561 ctgatctgta tagggatcgc actttctaac agatgcggtc tgccgattat tcctacagat
     4621 ctgtttcctc gtgaactgtc agagattata aaggtgaaat attctaagat caaggtttct
     4681 tttgatgtga tctgtctgat gattactgcc tgtatgacag ggctgatcct ggggcatatc
     4741 aacggactgg gaatcggaac agtgatggcg gcatttacca tgggaaaagt aattggattg
     4801 attggtgatg agatggataa gcacttccgg tttgtgaatt tcactcagca ctgttcactt
     4861 catgtacagt aacagagttt cttcattgca ggatttttct ttctatgata tacttgacgc
     4921 attatagaag taaagatatc ataagaaatc tgtgatggaa gtatgttgca actctggtat
     4981 ctgaaaataa tatattaagg aatagtgatg cagattatga aacggttgct cataaaaaac
     5041 aaaagaaagc tctggctttg gtttctgctc cttgtttttt tgtttctggc atgcagagct
     5101 gcttacatta caggcagcaa agcagaacag accagaaata atgaagtaga agaaaggcag
     5161 gcagatagtc ggtcaatacc gaatgaaatg gagatattat gttgaatcaa ttttcaagaa
     5221 cagagcttct tctgggaaaa gaagcaatga ataaactgga gaactcccgc gtggcagtgt
     5281 ttggaatcgg aggggttgga ggatatgtat gtgaagcatt ggtcagaagc ggtgtgggga
     5341 cctttgatct gatcgatgat gacaaagtat gcctgacgaa tcttaacaga cagattattg
     5401 ccaccaggaa aactgttggt caatataaaa cagaggtgat gcgggacagg atcctggaca
     5461 ttaatccgaa agcagatgtg agaatccata actgttttta tcttccggag aatgctgctg
     5521 atttcgattt tagtgagtat gattatgtgg tagatgctgt ggacacagtg actgcgaaga
     5581 ttgaactgat catgcgtgca aaggaggcag ggactcctgt tatcagcagt atgggtgccg
     5641 gaaataagct ggatgccagt gcgtttcggg tggcggatat ctataagacg aaggtgtgtc
     5701 cgctggcgaa ggttatgcgt agagagctga agaagcgtgg tgtgaagaaa ctgaaggttg
     5761 tttattcaga ggaacagccg atcagaccaa ttgaagatat ggcgatcagc tgcaggtcgc
     5821 attgtatttg tcctccaggt gctacgcata agtgtacgga gcgcagagat attccgggga
     5881 gtgtggcctt tgtgccgtct gtcgtcgggc tgattattgc aggagaggtt attaaagacc
     5941 tgactgcgga gtacagaaga taagaagtgt ttattttgag atgtgtatgg tgtcagaaat
     6001 ggtatggtac acatcttttt ttgcgggaaa tattttgaat tggattgatg gattacctgt
     6061 tagagtgtat agaattgtta tatgagaaaa agtcaaaata acataaaaat ttataggatt
     6121 ttcaaaatat aatgaaagaa aaaagaaaga atctgtgata cactgtcatt attgattgat
     6181 agaactgtga aggtgcagaa tttggtgaat gagaatgcct gaacgatatc agcgtaataa
     6241 attgttactg cttactccgt tctcagtaac taataaattt cagattggag gatatcatat
     6301 tgaatgaaaa caaattacaa cagaacagtg caggcctgtt ttatcggata tgtagtgcag
     6361 gccattgtga acaatttcgt tcctctgctg tttctgacat ttcagggcag ttacgggatt
     6421 tcgctgcaga agatcacact tctggttaca tttaatttcg ggatccagtt gctggtagat
     6481 ctggcatcga ttggatttgt ggacagaata ggttatcgtg catctatgat cctggcacat
     6541 gcaatggcgg ctgcaggtct gattttgctc acagtattgc cggagtgcct gggagatccg
     6601 tttgtgggac ttctcattgc agttatgatc tatgccatcg gaggcggatt gctggaggtg
     6661 ttggtaagtc ctgtggtgga agcctgccct acagataata aggaaaaagc aatgagtctc
     6721 cttcattcct tttactgttg gggacatgtg ggagtggtac ttctttctac attattcttt
     6781 cgtattttcg ggattgcaaa ctggaaatat atggcgctgg tgtgggcatt gattcccatt
     6841 gcaaatggaa tcctttttac cagagttccc attgctccac tgctggatga gggtgaaaag
     6901 gggctgacta tgggagagct ttttaagaaa aaaatcttct gggttctgat gttaatgatg
     6961 ctctgtgcag gagccagtga gcaggcggta agccagtggg cttctactct ggctgagaaa
     7021 agctttggaa tcaataaaac tatcggagat ctggcaggtc ccatggcgtt tgcaattctt
     7081 atgggaagtt caagggcatt ttatgggaaa tttggagata aaatcaatct ggaacgcttt
     7141 atgcaataca gtgcagttct gtgcatggtt tcctatctga tgatcgcatt tatcccggta
     7201 cctgcgttgg gaatccttgg atgtgcggtt tgcggtctgt ctgtaggtat tatgtggccg
     7261 ggaaccttca gcatggcggc tgcctcagta aagcgtggcg gaacagcctt gtttgccctc
     7321 cttgcccttg ctggagatgt gggatgctca tccggaccaa cctatgtggg gatgatttca
     7381 ggagcactga atgataatct gaaacttgga atcttcgcgg cactgatttt ccctgtgttg
     7441 atgataatgg ggattaagat gattggaagt ctgcgaaaat atgattgaga tatattaaaa
     7501 agtatggaac gattaatttt tcatattgat gtaaacagcg catttctttc ctgggagtca
     7561 gccagaaggg taagccaggg gctgccggat ctcagggaga ttccctcctg tgtgggagga
     7621 gatccaaaga aacggacaga gtacacacgc tgttcccgga cgaaataccg gagaaaatgt
     7681 ggccacttcc tgtccgtaac ctgttatttc tgggaaaagc ctccgagcag aagcttctga
     7741 atcagggaat ccgtactatt ggtgatctgg caagggaacg ggaagcaaat gtacagctct
     7801 ggcttggaga aaaaccagag cacagatgaa aaatgaagac agacaggaag aataaaagcg
     7861 cagagatgat actttttctc tgcgctttta tagcggactg ttatacatat ttcagaaatt
     7921 cttcatcctg gatccgggaa gtatggatgg cattttggat agcctgagcc atgacttctg
     7981 cggcgagagt tcctgccata ttgatatcta cagaaacatc gccaatgctg gcagcataga
     8041 tggaatcgcc gtcagccata gttgctacag gattgatgca tctggcatag gcacagcggg
     8101 tcatagaggc aattttattc agttcagcct ttgaaaatgc cccattggtg atcacagccc
     8161 cgatggtggt attgccggta aactggtcat gaggtgtcat aaagcggtat aattcgtgga
     8221 cactgtccag aaacccgctt ctgtcaggtg ttttcagccc tgcaattttc tgaccatttt
     8281 gtggactgaa gatatctccc agtgcattga caacgacaat tgcggccatc tggaaatttc
     8341 ccactgatac agcggcaata ccaagacctg acttcatgga ttgtttcata ccgtaaagtt
     8401 ttcccacagt tgcaccggta cctgcgccga tattcccggt tctggcatct gttcctgcaa
     8461 atgcctgacg gcaggcttct tcgcccattt ttgcagttgg acgtatttta ggatctccgt
     8521 aagagaggtc atagatacag gactggcata caagaggaac cagggctgca ccggtgttat
     8581 aaccgatatt ttgtgattcc agatagttca tcacaccgtc agcagcagcc agtccatagg
     8641 cagaacctcc ggacaagaca atagcattga tgggattgtc ggcagtgaca ggagaggtga
     8701 gaggagtttc cctggaagca ggaccgccac cgctgatatc acagccaacc tttgcaccca
     8761 gtgggaagta aagaacggtt accccggtct gggcattata atcggaagca tgaccgatgc
     8821 gtaaatttga aagatctgta atagaaatct cttttaataa tgacataaaa atctcctttg
     8881 tattaaccga atcaggtagg gttcctgctt taaatgtgcc ggataaaaaa atcctgacta
     8941 cagtgacaat gtagtcaggg ttgtttggta aacggctgtt cttttaaaga ttatgcacgt
     9001 ttcagtgcca cagaaagtgc cttggaaacg atgcttccca ctacaaagca gaagcccgct
     9061 tcgatcagtc cctgaacgcc cacaaaagca gcaacgaaga caacaggatt gcttactcca
     9121 agactggaaa caataccctg aatgtaatct gtgttgtaga agaagagaca taaaaagccc
     9181 atgaagaaga aagtattcag taacgggcat gccagtgaag caacgtaata ggaaaatttc
     9241 ttcgccggtg atttatataa tgctgcgaaa ataagtcctg tgatccatcc ttccagcaca
     9301 cgtgccacga tacacacaat aaaagtgcca aatggattaa tgttaaaaag tgcggcagcg
     9361 aaagctgaac ttcctgtgac agccatatag aagctggttg caccgaaagc aagtccgcat
     9421 acagcaccac ctttcggtcc gaggatgata gctcctacag ctaccgggat ggtgagaaga
     9481 gtgatggata agccgggagt acgaaggtag cccagcgggg taaaggacat gagcagaata
     9541 atggcaatca tcatagccag ctctaccatg taaagagtgc tgcttctttt tgtggcagct
     9601 gttgtagtag tagttgttgt gttcatatga attctccttt tggtctgata aaacggcgca
     9661 atgcgtcccc tgcttttcag acagtttaga gtatggggat caggcgttat gaaaaatata
     9721 catcagaaca aaagatatga aacaagaaat atcttccggt aaaagtttcc ggtgtgtaga
     9781 cgccttacag gtcgcctcac aaatttaacc agactgtgaa gtggatgact ttatccacca
     9841 gactgtcaga tgtggaaatc agatgcattt tctttcgaat aacgctcccg taaacaataa
     9901 cacatttgat taaaaactgc aatattttat agtatgtttg aaaataaata caggatatag
     9961 aggtgtttct atatcctgca aaaaatattg attatgagat ttagcgttcc atcatgctga
    10021 tggattcaat tccaacgctt ccaccgcgga ccacttcaat tctgtggaat tcttccttga
    10081 tcagtttaac aactgcatca ttcttggtgg ctgtctggac aaattccaga agcaggctgt
    10141 ctttgccgta gtcaatgact tttgcctgga aggtttctgc aatctgaaac agttctgctt
    10201 tatcttccct ggagcagttg aaaaccttga tgtagagaat ttctttcatt ctgacaaata
    10261 catctgtgaa gtcgattacc ttgataacct cgatcatgcg gtttaactat tttttgatct
    10321 gttcaaaggt ttcatcatcg ctgactgttg cgatagtcat tcgggatact gtaggatcct
    10381 cggtggttcc tacagtaaga ctgatctatc acgagatatg taaatggtta agtgagtttt
    10441 gttaattaaa atgtactaaa atgtcgtctt ttttgacaag aaattataga aaacaaacaa
    10501 aataacacaa tgcaaaaaac aatgcataaa ataaaagaat gtccctttga ggaacattct
    10561 tttaacgtgt ctgaaggaaa acttttaatt tgggaagctg gttgttaagg ataagagttt
    10621 ccggaaacat gagctggtga acgaattctt cggcataggt gaaatctcca acatgttctt
    10681 ttccgtggct gtcgctggac aaaataacag gaagctgata tttctgacag agatacagga
    10741 ttctggcggc attggctctt gtgtctcccc gatatcctcc gggtgcgagg gaagcttcgt
    10801 ttatttcaaa aataacattt tcccgtaaag ctgctcttgc cagcgtttca taatctacag
    10861 ggaaatgtgt atcgtcgcag tggccgagta tttttacagc aggatgtttt attgcattga
    10921 tgtaagcttc tgtattctga gatacagagc ctgaacggta gttctgccga tgcatactga
    10981 tgatagcgta atccaggttg ttcagcagtt catctgacag atctgtatgt cctgcactgt
    11041 ccaggatgtt tagttcaact ccgtaaagaa tatctatgcc gaatcttttt ctaggataaa
    11101 aaggaaggct tctgaaataa gaagaagttc cggaagccag agttcccggg ccgtggtcag
    11161 aaatcccaag gagtttcagt ccttttttgc tggctgcttt tgccatgtca gagatggtac
    11221 aggtggttcc gtgaccgctg gcgatagaat gtgtgtggat gtcagaaaga tacattgttt
    11281 gtctcctttc cagagcggtt tctatatatg ataagagcct tacggaagat gcaaagctgc
    11341 tgtttgatgg tacattcgtt atattcaagt atgacagatg aggatttaaa tgtcaatgag
    11401 gaaacaaaat aaaaacaact gaaatacaac aaaaatcaaa taaaaagcaa cacaaataaa
    11461 cggctgatac atgttaaatt atgttgactt cgggaaaatg agaaggtata atggaactat
    11521 atgaaaacac gggggcttat tgctgatcaa tgacagcgat agcactgttt gcttatgtgt
    11581 agacagttac ttcatgagaa aggagtaaca tggaaaaatt tcaaacatca gacattcccg
    11641 gaattctctt atgaatggct ggaggctgaa ctggatactg gtatgattcc acaaatatgg
    11701 acagcgaaga aattgctccc aacctttatg actaatcgat aagtatatat cgagaggaaa
    11761 tgaatcctca gaattaagta aaaaaagtta ccgggaacaa tgtgaccggt agcgaaatac
    11821 agacgccgca ctgccgtatg gcaagtgcgg cgttgttgtt caaaactctg atagcagagt
    11881 gaaatcaaac aaatataaat acagtaacag ctcagacaag atgatgtaaa taaagacact
    11941 tttttggaca aacgaggttc ttaccctgga gagcagatca gggtaaaatg aaatcatcag
    12001 atatgaagag cgcaattcat atattggagg aagaacagtg aaaagtacgg aacgattaat
    12061 ttttcatatt gatgtcaaca gtgcatttct ttcctgggaa tcagccagaa gggtgagcca
    12121 ggggctgccg gatctcagag aaattccttc ctgtgtagga ggagatccaa agaaacggac
    12181 aggtatcgtg gttgccaaat ctatccctgc aaaaaaatac gggatccaga ccggcgagcc
    12241 agtagccatg gctcttcgga aatgtcccaa tctggtgatc gttcccagtg attttgaatt
    12301 atacgataaa tgttcccggg catttaaagc aatctgtgct tcctttgcac ctgtgatgga
    12361 atctttttcc attgatgagg tatttctgga tatgacaggt acttctctga tctatcctga
    12421 ccctgtagct gctgctcatg agctgaaagg caagattcac agagagctgg gatttacagt
    12481 aaatgtagga atttctacca ataagctttt ggcaaagatg gcatcagatt ttcaaaagcc
    12541 ggacagagta cacactctgt tcccggatga aatcccggag aaaatgtggc ctcttcctat
    12601 ccgtaatctg ctgtttctgg gaaaagcttc cgagcagaag cttctgaatc agggaatccg
    12661 taccatcggt gatctggcaa gagaaagagc atccaatgtg cagtactggc ttggggaaaa
    12721 aacgggacat cagctatggc aatatgccag aggtatcgat gattcccctg taaaagcagt
    12781 gcctgatgag gcaaaaggtt tcagcgtgga aactactttt aacgatgata ttacttccat
    12841 agagcaggtg tttcccatac ttttggagca gtgtgatgtt ctggcaacca gaatgcgcag
    12901 aaaagataag aaatgcaact gtatttccgt gactttccgt actttggatt tcagaaaccg
    12961 ttcacaccag acaaagctgg aaaatgctac agatcttaca gatgaaattt atataaatgc
    13021 tacaagactt tttaaagaat tctggaaagg acagccgctg cgtctgattg gtgtggcact
    13081 gacaggcctt acagatggca cttatgaaca gatgtctctg tttgaagata cagaaaataa
    13141 agaacgccac agaaagctgg atgcagctat ggatgagatc cggatgaaat ttggaaatga
    13201 taagatcacc cgtgccagta ttatgaacag caatgcacgg attgggcgaa aagcgaaagc
    13261 acagatgaaa aacgaaaaga cggaagaacc gtaagtaaag agaggactga gcattaagaa
    13321 caatgcgaca atcctccctt tataaaaatt tcagaaaaag ttttatcgtt ccatcatact
    13381 gatagattcg attcctacac ttcctccacg taccacttca attctgtgaa attcttcctt
    13441 gatcagtttc actactgcgt cattcttggt tgctgtctgg acaaattcca ggagcaggct
    13501 gtctttgcca tagtcaatga cctttgcctt gaaggtttcg gcaatctgaa acagttcaac
    13561 cttatcttct ttggaacagt taaaaacctt aatatacaga atctctttca tgcggacaaa
    13621 tacgtctgtg aaatcaataa ccttaataac ctcgatcata cggttcaact gttttttgat
    13681 ctgctcaaaa gtttcatcat cactgacagt tgcgatcgtc attcgagata ctgtggggtc
    13741 ctcggtggtt cctacagtaa gactgtccag attgtagctt tttccggaga aaagtccgga
    13801 gattttggac agaacaccta cctggttctc aacatagaga gaaatccatc tttttttcat
    13861 tcctttatcc ataataattt tcctcctgat caacagtcca taatcatatc ttctagagtt
    13921 ccgcctggtt tgatcatagg ataaaccatt tcctcagggt caatgatgaa ttcaattact
    13981 gtaggtgcct ttgtgttctt ttttgcttcc tcgaaggctg ctgcaatttc ctcttttttt
    14041 gtgacacgga ttccttttgc cctgtagctc tctgcaagtc tgatgaaatc cggtgtgtac
    14101 tgtggatatt ccatgccttc agtgcggcgg gaaagtgctc ctgcgcgcag attggtcata
    14161 gcatagcgtt tgccgtagaa aagcttctgc cactggcgta ccattccaag atactcattg
    14221 ttaaagatac acaggataac cggaagctcc tccagaactg cagttgcaag ctcctgaatg
    14281 ttcatctgca caccgccgtc accggagata acgatgacag gtctgtcggg atttccgatt
    14341 ttggctccga tgccgcctgg aagaccatag cccattgttc ccagaccacc ggacatgatc
    14401 atctgtttgc cctctgtgat ttccgcatac tgggagacaa gcatctgatg ctgtcctaca
    14461 tctgttacga taatactgtt ctcaaattgt tcgttgatct ctttcaggat atccatcgga
    14521 cttaaaagat catttggacg cattttaagc ggatgctctt ctttccagtt tttgatcagg
    14581 ttaagccact tgtccgttga acattcctgg acgtattcgt tcattttggt gatagcctct
    14641 tttgcatcag caacaatggg gatatccacc tgaatgtttc gggaaatgga tgctgtatca
    14701 atatcaatgt ggataatctg ggcatgtggt gcaaattcat gaagttttcc ggtgattctg
    14761 tcattgaatc tggttccgat ggagaacagc acatcgcagt tgctgactgc catatttgct
    14821 gcataggcac catgcatgcc aaggtttccg atatagagcg gatggtctgt ggggatagag
    14881 ccttttccca ttacggttgt gacaaccggt acttttgtct tttccactac ttcccggaaa
    14941 atttcatggg cgcgggagat tactacaccg ccgcctgcca ggaataaggg acgttttgct
    15001 ttatttaaaa gtttgatggc acgtttgagc tggccgatgt ggacatctgt gttgggcttg
    15061 tatccgcgga tatttacatt tttaggatat tcagcgctgc cgagttctgc cattacgtcc
    15121 tttggaaggt cgataaggac aggtcccgga cggccggtgc gggcaatgta gaaggcttct
    15181 ttgatgatac gtcccaggtc ttcacgtctg cggacggtaa cgccgtattt ggtgatgctt
    15241 ctggtgattc ctacgatgtc tacttcctga aatgcatcgt tgccgatgag gtggcgggct
    15301 acctggccgg tgaagcatac aagaggtacg ctgtcatagt tggcggttgc aagtcctgtt
    15361 acaaggttgg ttgctccggg accgctggtt accagacata cgccgacttt gccggtggtt
    15421 ctggcgtagg cgtctgcttc gtggacaagg gcctgttcgt gacgggggag gatgattttg
    15481 acatcgtcct gtttgtagag ttcatcactg atgtcgatag tacaggctcc ggggtagccg
    15541 aagaggtatt ctacgccttc ttcttttaag gctttgacta agagtttgtt gccggatatt
    15601 tgtttcatat ttgggtaaac ctcctttgtg tatgtgtata ggacgctcag aaatttattt
    15661 gtttggtgtg cggtttcgga gcctagtaga tctaagtgtc tgaaaatctg ctaaaagcgt
    15721 tcagaaaaat ctcaaactcg ctgcgctcag acagtgagat ttttctgaac aacgcagatt
    15781 tccaggcact aagatctaca cgactcctgc aaatgcacac caaacaaata aatttctgag
    15841 ctgtgtattg gctgatacag gggcagaatg gcgctgcgct gattctgctg agaacgctgt
    15901 aaagcagctc ccacaattct gaatatagta aaaaacgccc tgggcttatt gcccagggcg
    15961 aaaatgtctt ccgcggtacc acctgtattc agagcttggc tctgcacttt gtcagtactg
    16021 atatactgtg ttcctgtaac gtggaactga cgttgaagcc tacttggcat gtctgtccgg
    16081 atctatggat catcagactg gatatgcggt ttggttcact gctcgggggc tacttccaca
    16141 attcgttcac gaaagctcgc accgaccgct ttctctctgt gcttcccggg ggtgtgtact
    16201 cctccctgtc atggcatttg gctgatatgg ggatattcat tgtccgaata gggtggacaa
    16261 atgttttctt gggttacatt atacatttgg agagaggaaa ttgtcaaccg ggttttggat
    16321 aattgctgta aaatttatgc tctggaatga attttggtta cgttactgag aacggagtga
    16381 acagtaatgt aattgacaga tttctatatt gctgatataa aaaataaata atacagatgt
    16441 ttggaaggtt attaacagtt aaatataaat tataaaatca tataagcaca tgttgagttt
    16501 tacaagatat tagagtagaa tattattgaa aggagttgat tctttgagta aatattattc
    16561 tatacatgaa ttttcaaaaa ttataggcgt atctgcccag acattacgaa attgggatgc
    16621 caatggaaaa cttcatccgc atcatactac agtaagtggc tatag
//
