LOCUS       gnlProkkaPOHGCOAF_26   13851 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|POHGCOAF_26.
ACCESSION   gnlProkkaPOHGCOAF_26
VERSION     gnlProkkaPOHGCOAF_26
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 02:40:20
            Original ID  :: gnl|Prokka|POHGCOAF_26
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 105261
            Orig. end    :: 119112
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13851
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10345]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10345
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13851
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13851
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2131..3165
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_71"
                     /sec_met_domain="PF04055 (E-value: 1.2e-17, bitscore: 57.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRLRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
     CDS             3184..4224
                     /locus_tag="ctg26_72"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQNQIPLGEASKE
                     AEQTNK"
     CDS             4229..5323
                     /locus_tag="ctg26_73"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5333..6574
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 388.5; E-value:
                     7.7e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg26_74"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6561..7088
                     /locus_tag="ctg26_75"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7094..7867
                     /locus_tag="ctg26_76"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7874..8269
                     /locus_tag="ctg26_77"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVVKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             8517..9905
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 95.3; E-value: 4.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg26_78"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGYTDEGGAFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSLMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10345
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_79"
                     /sec_met_domain="PqqD_RRE (E-value: 2.6e-10, bitscore:
                     32.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.7e-17, bitscore: 55.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPAGMSKELHVRLEEHGTAVWELIDGKRTVREIIEELADHFQNEAGYESRVSAYLSQMQ
                     KDGFIKLFIN"
     CDS             complement(10607..10891)
                     /locus_tag="ctg26_80"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLSEGREASRLRRERANDKLKHLNRTNEPYPLP
                     NTTPEEMGRIIHDSEKKKEKDSNYFVWGTLIIMGVLIATAVIFWAIFLN"
     CDS             complement(10915..11982)
                     /locus_tag="ctg26_81"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGITRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSTEPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSKSSSDKKTAPAPTVLSKIANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTRD
                     KEEKTFTVRLTPDREFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(12055..13566)
                     /locus_tag="ctg26_82"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEEIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
ORIGIN
        1 gctacgctca tttccagttg aatggctttt cacaggcgga tgccaagtcg ttctcaaagc
       61 aatatttgtc tacttactcc aaggctttgt ctgcacagca ggaagatatt cttgcttcgt
      121 gggtgctggc taaacaaccg cgctgtttaa gtgtattgct caacgagctg gtttcgttcg
      181 gtcagtacga tgctctcaat gaatatatgc gtggatattg ccggctcaat gaggttgggc
      241 aattctatga cagtgtgcta cggcgtttgt cggctgatta tggtttcgaa gagattggaa
      301 gaacgcttct gatgctttca cttactttag aaggatttac cgaagatgaa gtgaagagca
      361 tggcagacat taatcagata ctttggtcgc agttgagagt ggaaatgagc agctggctca
      421 ccaacaaagg aggacgatat tgcattggtg acacacaaat ggtagaggcg atcgaacgct
      481 atttcgctca agatgacgaa tgtatagatg atagtcgcca tgaaattatt tccgctctgc
      541 tggatgagga agaaatcctt tcccatccgt tgacttttgc cgattataac tatcgcatga
      601 aacagttctg ctaccatgat tcgtatcgct ataaagtgga gattacctat caatgctata
      661 agatgcaaga atgggatata ttgaaggatt ggatttgtga tgtggagatt ttcgagattc
      721 tgtatcgcac gaatcgttct ttgttggaag atagctggaa agcgatcatg aacgacaatc
      781 ctgaagttac gcctgaagtc tatgccgaat tggactttga tgagatcgat tcttttttaa
      841 ttcctgttat tgctaatgat atggctactt tcttgagcag ttctttccat ctgacgaagg
      901 cggcagctgc tgtgagtgag aagagtatgg aaggtgctgc tatgccactc attgccaagt
      961 cggtattgaa gatgaatgag ggatgccgat atgcccgtaa tgaagaatac gaaacggcat
     1021 gcgactgttt cctgaaagca ttggtgatgc aggaaaacat tgtaccgatt ccggaactgg
     1081 agattgccaa cacctgtcga aatctagctt tggcatatta ctacaatgag caatacaatg
     1141 aagcggcgat ctatttgaat agggcgcttg attatcatgc ggcttctgct gacgagaaga
     1201 gtcaggcaga agtcattgaa ctttccgaat atctggctta ttgtgattac tataaggatg
     1261 aggaagagag tgctgccgag aaattccgga aagttgctga aatgcacgag tcattgaatg
     1321 gcagactgtc cggtggagtg gctaaatgtt tgcgtatgca gggtaaatgt ctttattata
     1381 tcaaacgata cgatgaagca tggatgctga tgaatcaggc gttggacatt gctatacaga
     1441 tagataataa aaaacagatc gtcgcttgtc ataaacagtt gtattatcta tgcagggaat
     1501 tcaaacggat gatgaatgaa cgtggtgatg agcaggcgtc tactttattc ttccgtgagt
     1561 ctcttctgca tgaaatgtat ttcagcgaaa aaccgcgtct ggcggaactg actgtccgct
     1621 atgaggcatt gagatgtgat attatgcagc agtattacat gaataaagac tatgataacg
     1681 tgattcgtat tgcaacgtct ttggattttc acgatgatgc tgaccctaat gcttcctgtc
     1741 tggtatatta ttacaaagca caggcttatg tgaagttgga gaattatcca atggcgaaag
     1801 aggctttctt cagagagttc gaactgcgaa agaagtattt gggatgggag gatgaagata
     1861 cgattctggc ttgtcagaac ctaggggttt tgcacagctt ttgtaatgaa cgggaagagg
     1921 cgctggcttg tttccgtgag gcgtacggtc atgaagtgaa aaagaatggc gaggattctg
     1981 aaatggcgca aaagctactt caatatatca gcgtggttga atcataacgg aggcatactt
     2041 cccttttttg ttaactttta cattcctgct atacggaaat cgactttatt tccttacatt
     2101 tgcagatata aactatcaac agaaagaaga atgtctaaat atcccctttt aggaatgact
     2161 cttgtagagc ttcaatcatt gacaaaaaga ctgggtatgc ccggctttgc tgccaagcag
     2221 attgcatcct ggctttacga aaagaaggta gcctcgattg atgatatgac taatttgtca
     2281 ttgaaacacc gggagttact caagcagaac tatgaggtgg gagcggaagc tccggtagat
     2341 gaaatgcgct ctgtagatgg tacggtgaag tatctttata aagtgggtga gaaccatttt
     2401 gtagagtcgg tttatatacc ggatgatgac cgggcaacgt tgtgcgtgtc gtcacaagta
     2461 ggttgcaaga tgaactgtaa gttctgtatg accggcaaac aggggtatac ggctaacctg
     2521 accgccagcc agatcataaa ccagattcat tcgctgccgg aacgggacaa actgactaat
     2581 gtcgtaatga tgggaatggg cgagccgctc gataacctgg atgaggtatt gaaggcattg
     2641 gaactactga ccgctaccta cggttacgca tggagtccga agcgtatcac gctttctaca
     2701 gtcgggctac ggaaaggatt gcagcgtttt attgaagaaa atgactgcca ccttgccatc
     2761 agccttcact ctccgctgac cgttcagcgt gctgaattaa tgccggcgga aaaggcgttt
     2821 tcaatcaccg aaatggtgga actgttaaaa aactatgatt ttagtaaaca acgtcgactt
     2881 tcgtttgaat atattgtttt taaagggctc aatgattcgc aggtctatgc caaagagttg
     2941 ctgaaacttc ttcgcgggct ggattgcagg gtgaatctga ttcgttttca tgccataccg
     3001 ggggtagacc tcgagggggc ggatatggat acgatgaccc gtttacgtga ttatctgacg
     3061 tcacacggac ttttcaccac tatccgttca tccaggggcg aagatatttt tgccgcttgc
     3121 ggtatgctgt cgacagcgaa acaggagaaa aataatgaaa gttaatatat aaaaccgaac
     3181 atcatgaaaa agtactcttt tattttatgc atcgctttgg tagcctttgt cgttgcatct
     3241 tgtggtctga aaggaaatca cacctctagt ggtcgtgctt acgagctttt ggttgtagta
     3301 gatcacggtg tttgggatcg tgctgccgga agggctttac atgatgcgct cgatgctgat
     3361 atgcccggtt tgccgcagtc ggaaccttct ttccggatta tgtatacttc gccgaaagat
     3421 tatgattcta cgctgaagtt gatacgtaac attattattg tagatataca ggatatatat
     3481 acgaaagcct cgttcaaata tgcgaaggac gtgtatgcca atccgcagat gatattgact
     3541 atccaggctc cgaacgaaga agagttcgag aagtttgtgg aagagaacaa aaagacgatt
     3601 gtcgacttct ttacccgtgc ggaaatgaac cgtcagatta cgttcctgga agggaagcat
     3661 agtaacttca tttcgcagaa agtggacagt ttgttcggat gcgacatctg ggtggatgcc
     3721 gaactggcta attcaaagac cggggatgat ttcttttggg cttctaccaa cacaggtagt
     3781 gccgaccgta actttgtgat gtactcttat ccgtacactg acaaggatac gtttaccaaa
     3841 gaatattttg tgcacaaacg tgactccgtg atgaaagcca atatccccgg attcaaggaa
     3901 ggcgtttata tgtcaaccga tagtttgctg accgatgtcc gtccgatcaa tgtacagaac
     3961 agctacacaa tggaagcacg tggcctgtgg cgtatgaagg gcgactttat gggtggcccg
     4021 tatgtatctc atactcgtct ggacgagaaa aaccaacgaa ttataacagc agaaatattt
     4081 gtttattcac ctgataaaat gaaacgcaac ctggtacgcc agatggaagc atctctgtat
     4141 acactgaaac ttccgaatga agttcagcag aatcagattc cattgggaga agcatctaag
     4201 gaagcggaac aaactaataa ataaaaacat ggaagataac aagataagga taggtatcac
     4261 ccaaggagat attaacgggg tgggctatga ggtgattctt aagacatttt ccgaccctac
     4321 gatgttggaa ctatgtactc cgatcattta tggctcaccg aaagtagcgg cttatcatcg
     4381 caaagcgctg gatatacaga ccaatttcag cattgtcaac tctgctaccg aagcggggta
     4441 caaccgtttg agcgtggtga actgtacgga tgatgaggtg aaagtggaat tttccaaacc
     4501 cgaccccgaa gccggtaaag ctgcgctggg ggctttggaa cgtgccatcg aagaatatcg
     4561 cgaagggttg atagacgtta tcgtaacagc tccgatcaac aaacatacga ttcagtcgga
     4621 agagttctcc ttccccggac atacggaata tatcgaagaa cgtctgggta atggtgataa
     4681 gtcattgatg attttgatga agaatgactt ccgggtggct ttggttacga cacatatccc
     4741 tgtcagagag atcgcgacta cgattaccaa agaactgatt caggagaaac tgatgatatt
     4801 ccatcgttgc ctgaaacagg atttcggtat cggcgctccg cgtattgcgg tgctctctct
     4861 caatcctcat gccggagacg gtggtttgtt gggaatggaa gagcaggaag tgattatccc
     4921 tgccatgaaa gaaatggaag agaaaggaat cctttgctac ggcccttatg cggccgacgg
     4981 ctttatgggt tcaggcaatt atactcattt tgacggtatc ctggcgatgt atcacgatca
     5041 ggggctggct ccgttcaagg ccttggctat ggaagacggg gtgaactata cggcaggcct
     5101 gccggtagta cgtacttctc cggctcatgg aacggcatac gatattgcag gcaagggatt
     5161 ggcttgtgaa gattctttcc gtcaggcaat ctatgttgcc atcgatgtgt tccgtaatcg
     5221 tcagcgggaa aaagtggctc gtgccaatcc gttgcgtaaa cagtattacg agaaacgtga
     5281 cgatagtgat aaactgaagc tggatacagt agacgaagat taaaaacgag tgatgacgag
     5341 agcagagata caacaagtga aacaacgttt cggtattata ggtaataccg aagcattgtc
     5401 gcgcgccata gatgttgcca ttcaggtagc tcctaccgat ttgtctgtgc tgattaccgg
     5461 agaaagtgga gtcggaaaag aaagttttcc gcagattatt catcaatata gccggaggaa
     5521 gcatggacag tatattgctg tcaactgtgg tgctattccg gagggcacga ttgattccga
     5581 actgttcggg catgagaagg gtgcgtttac cggtgcgatt ggcgaacgga aagggtactt
     5641 tggcgaagcc gacggtggta ctattttcct tgatgaagta ggggagttgc cgatgcctac
     5701 ccaggcgcgt ttgctccgtg tactggagag tggcgagttt atgaaagtag gttcgtccaa
     5761 agtacaaaaa acggatgtgc gtgtggtggc agctaccaac gtcaatctga cgcaagcgat
     5821 tgcagaagga cgtttccgtg aagatttata ttaccggttg aatacggtgc ctatccagat
     5881 accgcctttg cgtgaacgtg gtgacgatgt acttttgttg ttccgtaagt tttccgcaga
     5941 ctttgcagag aaataccgga tgcctgctat tcagttgacg gaggatgcga agaaagagtt
     6001 gttggcttac ccgtggcccg gaaacgtgcg tcagttgaag aacatcaccg agcaaatatc
     6061 tatcattgaa accaataggg agatctctgc tgctatcttg cagaattatc ttcctgcaca
     6121 aaatacgcaa cgtcttcccg cgctgatggg aacgcgtgag agtaaaggct ttgagagcga
     6181 acgggagatt ctttattctg ttctgtttga tatgcgccag gaagtggcgg agctgaagaa
     6241 gatggtacac aacctgatgg cggaacgtgc cggacaggtg gggcaggtag ggcaaatggg
     6301 aacggtggtt actactccgg tagtgacggc gcatcaacct tcagtacctg ctatcattca
     6361 caccatgcag cctacggttt gcaaggatga tgatgacata caagacacgg aagaatatgt
     6421 agaagaacct cctttgtcac tggacgaagt ggaaaaagaa atgatacgca aagcacttga
     6481 aaggcatcac ggaaagcgga agagtgcggc caaggacttg aatatttccg agcgtacact
     6541 ttatagaaaa ataaaagaat atgaattgga ttaagaaaat aatacgccct ttgttactgt
     6601 tcggcttgcc gttggtagtc attgcgtgca ctgtttccta taagtttaac ggatcgtcta
     6661 tcaattatga taaggtaaag accatttcga tagccgactt cccgatcaag tcggagtatg
     6721 tatatgctcc gttggcaacc aaattcaatg aggacctgaa agatatcttc atccggcaga
     6781 cccgtctgca actgctcaag ccgagtcaaa atgccgactt gcagattgac ggagaaatca
     6841 caggttacaa tcagtacaat caggcagtat ctgccgacgg ttattcttcg gagacgaagt
     6901 tgactatcac cgtcaatgtg cgttttgtca acaacaccaa tcatgccgaa gactttgaac
     6961 aacagttttc tgcgttccgt acctacgact ctacccagtt gctgactgcc gtacaggacg
     7021 gattgattgc tgaaatgtct aaagagatca ccgaccaaat ttttaatgca actgtagcaa
     7081 actggtaata taaatgactt ctgttaactt tcaacaatgg attcagcatc ccgagacgct
     7141 gaatagggat actttgtacg aactgcgcaa tcttcttgcg aggtatccgt attttcagtc
     7201 acttcgtctg ctgtatctga agaatctgta tattctccat gatattagtt tcggtggaga
     7261 actgcggaaa gcagttcttt acattgcaga cagacggcag ttgtttcggt tgattgaagg
     7321 tgaccgctat gatgtgcagg cacggaaaaa gggagtacct ctcacggagg tgctgaaaga
     7381 cgaaccgtcc gtagaccgca cattagcatt gatcgacgct ttcttgtcca cagtacccga
     7441 agaggtgact gcccggacca gtttcgacta ttcgatggat tacacctctt tccttttgga
     7501 ggagactccg gccacggaac agccggctga agaaacgccc aaactcaaag gcttcgaact
     7561 gattgacgac tttatagaaa agagcgagag cgactctccc ctctgcatga aacctttaag
     7621 agaagaaatg ccatcttcgc caacctcttc ggacgaactt accgaagaag aaacgatgaa
     7681 ggaagaagag gaagatgaca gctgttttac ggaaactttg gcaaaaatct atgttaaaca
     7741 gcaacgatat tcaaaagctc ttgaaataat taaaaaatta agcttgaaat atccaaaaaa
     7801 aaatgcttac tttgcagacc aaatcagatt tttggagaaa ttgattatta acgctaattc
     7861 aaaataacta aaaatgtact tattattcgt tatcttaatg gttattgcag ccttgttgat
     7921 gtgtttcatc gtgctgattc agaactcaaa aggaggcgga cttgcttctg gtttctcttc
     7981 atctaacgcc atcatgggcg tacgcaagac tacagacttt ctggaaaaag caacatgggg
     8041 cctggccatc tttatggttg taatgagcat tgctactgct tatgtagttc ctcgttctgc
     8101 agttgttaaa gatgcagtgt tggaacaggc acagaaagaa caacagacta acccgtataa
     8161 cttacccgca ggtacggctg cgccgcaaac tgaagctcct gctaccaatg cacctgctac
     8221 agaaactccg gcaccggcta ctgaaactcc tgctcctgca gcagagtaat tcactccgtc
     8281 gtcaggtaag actttggggt aaaaccatta atgggaaggt gcagacggat gctgcatttc
     8341 tttgatattt aagtgcggat tacgcagatt acacggattt tcaatgttcc gcgtggtcag
     8401 tgtaatccgc acttaacttt ttcttgtaaa aacaatctct ttgtgataga aacaaacgag
     8461 atttaactac ctttgttggc tgtataagat tattaactac ttttttaaat ataacaatga
     8521 cagaacattt gaaacagaaa ttgaatgact ccgccgtact ccgatggagt gttctagcat
     8581 tggtcgcatt tactatgcta tgcggctatt tcctcaccga cgtaatgtct cctctaaaac
     8641 ccatgcttga gaaagaacta ctatgggata gtcttgatta tggtttcttc acaagcgctt
     8701 acgggtggtt taatgtattc ctattgatgc tgatcttcgg tggtatcatt ttggacaaaa
     8761 tgggagttcg tttcaccgga atgggagctt gcttattgat ggtgtttggt tgtggattga
     8821 aatactatgc gatttctact acttttccgg aaggtgccat gctcttcgga ttcaaaacac
     8881 aggtgacgtt ggctgcattg ggatatgcta tctttggtgt aggtgtggag attgctggta
     8941 tcactgtttc caagattata gtgaaatggt tcaagggcaa ggaaatggca ttggctatgg
     9001 gacttgaaat ggctacggca cgtatcggaa caactctggc gatggtgttg acagttcctt
     9061 tggcagactt cttcggatat acggacgagg gtggtgcatt ccataccaat attcctgctc
     9121 ctattctgtt ttgtctgatt atgctgtgtg taggtactat tgctttcttc ctttatactt
     9181 tctacgataa gaaattggat gcttctttgg atgcagaagg tttggaaccg gaagaaccgt
     9241 tccgtatgaa agatattgtg tatatcatta ccaataaggg attctggttg atcgcattgc
     9301 tgtgcgtatt gttctactcg gccgtcttcc cttttatcaa atatgctgcc gacttgatgg
     9361 tgcagaaata taatgtagat ccgaaactgg cgggaacgat tcccggattg ttgccgattg
     9421 gtgcaattat cctgactccg ttgttcggtt cgttatatga ccgtatcggt aaaggagcca
     9481 cattgatggt gatcggatca ttgatgctaa tttttgtaca taccatgttt gccctgccta
     9541 tactgaatat atggtggttt gctactatta taatgattat attgggattt gctttctcat
     9601 tggtgccttc ggctatgtgg ccttctgttc cgaagattat tccggaaaaa cagctgggta
     9661 ctgcttacgc tttgattttc tgggtacaga actggggact gatgggtgtt cctttgttaa
     9721 tcggatgggt attgaatact tattgcaaag gtccggtggt agacggtgca cagacttatg
     9781 attacacatt gccgatgact atttttgctc tctttggtgt acttgctctg attgttgctt
     9841 tgatgttgaa agcagagaac aagaagaaag gatatggttt ggaagaggca aatatccaga
     9901 agtaacagtt acaattcgaa gtaacgttat aaatccgaga gtataaggtt tgaaaataaa
     9961 agagggttag tattaatgct ctgaaataaa aaaaagaatt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacgattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtacc
    10141 ggcaggaatg tcgaaagaac ttcatgtgcg attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgta ctgttcgtga aatcatagaa gaactcgcag atcattttca
    10261 aaatgaagcg ggatacgagt ctcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 gtttataaaa ctttttatta attgacttta ttagatgata ggtgataaat gatagttact
    10381 atgcggcata atagctagtt atatgatagt gcagcctcct aaggaggttt atcaaatatc
    10441 ctgtttaaag atatgaaaaa aggcaactga ttcgtaatga tgtagttgcc tttttagtat
    10501 tttgagaata tctttagtta cttatatttc ttatttactg aatatccctt atcatttagg
    10561 aagcatctcc catctatcat ttatcaacta tcatctaata aattatctaa ttaaggaaaa
    10621 tagcccagaa tatcacggca gttgcaatga ggactcccat gataataagc gtcccccaaa
    10681 cgaaataatt gctgtccttt tctttctttt tctccgagtc gtggatgata cgtcccattt
    10741 cctcgggagt ggtgttgggc agtggataag gctcgttggt gcggtttaaa tgcttcagtt
    10801 tgtcgttggc acgttcacgg cgtagacggg aagcctctcg cccttcgcta agccgacgta
    10861 tcatgtcgag catgtgtcct tcaccaccca tattctttgc cctttagaag tttactattt
    10921 gccttcttct ctatccactt ttaacaatcc tcccgtattc ggatcaaaat aaactttgat
    10981 tgtagaattc ttattgaata agacaggagc cagatattct atcacaccga attgagtaat
    11041 agggagttca ccttcgtaaa gtttcttttt accgtcggtc aatgtaacca ttgcttgtcc
    11101 gggcacgttg taggcgattc catccaaatc tttcttcttc ttaccgtctt cctgtgggat
    11161 cttgactgat ttcaggtctt tcaagctgat ataaaacgga gttcctgcca ggtcattgtt
    11221 ggcaactaca cccagtttct tggagaagcg gaaagcaact tcgttgttga attccctgtc
    11281 cggagtaagg cggacggtga atgtcttctc ttccttatca cgagtgccgg agaacatttg
    11341 cgtcattgct tcttcctgtg cattcagatt atcaagcata attttaagct gtgctccgtc
    11401 tgaaggcata ttgtcagctt gtccgcgcaa taaggcattc ttgctttcgc ggatgttata
    11461 gatctcttta gccaccagtt cagccatctt cgcggtagag ctggccatca gaatttcttc
    11521 ggtcaggaat tcgcggggat tcgctatttt tgagaggaca gtgggagcag gagctgtttt
    11581 cttgtctgaa ctgcttttac tgtaaggcac attgatggtt ttcacgatgc cgtcctctgt
    11641 cagttccatg agtggtgcta ctgttttatc cttcaatttt acgaagtaag tagtttcgct
    11701 gttgggtaca cctacggatt tcaccttcac actagccagt tcccaatact cttcgggttc
    11761 ggtggagacg ttggtcaatc gcaggtaacg atcagcgtat ttgctgaatt ctcctggagt
    11821 atagttgact ttgttggctt ttatttcaag ctctatttgg gttttgggaa gactgtagac
    11881 tactccgtaa tcttttcccc gggtaatccc tgtcagtact tcggtttgtg cataggcgga
    11941 cgttgtcata agtagtcctg ctgctataat caactttttc atattcggtt ctttttaact
    12001 ggttttgaaa acaaagttaa tgaagttatt gaaaaaactg taagttctta acttttattc
    12061 gcttacaagt cgccatgctg tcggcagaca ggtgataata tcgcttgcga tcattccgat
    12121 cattccttgc ttcttttgag cgacatcgcc cgccagtccg tgaatgtaag tgccgatttt
    12181 agcggcttct tcggtgggat aaccttgggc aagcagcgcc aggattactc cggtcagtac
    12241 gtcaccgcta cctccggttg ccattcccgg atttccggtt gggttgaaga aacatttacc
    12301 ttcgggggtg atgatggcgg agtaggctcc ttttaaaata atgtggacat gggcggcacg
    12361 ggccagttcg caagccttca tcagacgttc gtaagagtcc tggcatttgc cggtcagacg
    12421 ttccagttct ttcggatgcg gggtgaggat ggaacccttc ggcaggtggg taagtgcatg
    12481 acggtggttg gcgaggatat taagtgcgtc ggcatccact acaacaggag tctggcagtg
    12541 ttccagttgt tccaacaagg cagcttccgt ttcctcgttt cgtcccagtc ccgggccgat
    12601 gccgactgct tggtagtcgt ccgtatcggt aggtacggca aaacaggttt cgttgatgtc
    12661 ggtttctacg attgcttcgg gtatggaggt ctgcaagatg tcgttgttgc acattggtgc
    12721 atgaacagtc agcaacccta ctcccgaacg gaggcaggcg cgggcagcga gaacagaggc
    12781 tcctgccatt ccttttgaac cggcaatcaa tagtgcatgg ccgaagttcc ccttgtgggc
    12841 aaactgtttg cgtggcttga tgagtgaacg gatttcttct atttccaaca tttcgtagtt
    12901 agtctccatc tcttcaatac cgtcttcgct taattggata tccagcactt cccattctcc
    12961 gacaaattca gtgttctctg cgaaaagaaa ggcgagcttc ggcagttgca gactgaaagt
    13021 tacgtcggcg cggataatat tagcttttac gttgaatgta ttttcttctc ccatcagtcc
    13081 ggaaggaatg tcgatggcta ctaccatggc aggggaggaa ttgatgtatt tcactacggc
    13141 agcgaatcca ccgctcaacg gtttgttcag acctgaaccg aataatccgt cgattaccag
    13201 atgatcgggc gtcaggacgg gaggtacgaa ttgggtactg atttcgtgga attttacttc
    13261 ttccatcatt tctaccagtt ctttattggt ctggcagtcg ggtgaaagtt ctcctttcgt
    13321 gttgaagaga aatacctcga ttttatatcc tttttcagcc atcatgcggg ctacggcgag
    13381 agcgtctccg ccattattcc ctggtccggc aaagatagtg accggcgttt ccgtattcca
    13441 tctgtctgtg atggcttttg ttaatacggt tgctgcacgt tccatcagat cgattgatgc
    13501 aataggttcg ttctcaatgg tataagcgtc caatttcttg atactgctgc ttggaaatat
    13561 tttcattgcg atgttctttt agttttcgga ttacaaatgt acatgattct tctgactttt
    13621 cccgtttgtt gtgggaagaa aaccataatt gcaactttta attcatcatt agttctatct
    13681 tttggtcaaa gaaatatctg cttttgaact attaagtgtt agaataactc cgccaaaaaa
    13741 taattcaatg ctgcaccatt atgaacttac ttttatttct ccctgaaaaa gatttcggtt
    13801 cttcgtcaaa tttggtggta cttcttctat tgtgaataaa taatcttcgc t
//
