LOCUS       gnlProkkaCHKNGANP_61   10653 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CHKNGANP_61.
ACCESSION   gnlProkkaCHKNGANP_61
VERSION     gnlProkkaCHKNGANP_61
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 01:56:46
            Original ID  :: gnl|Prokka|CHKNGANP_61
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10653
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..117
                     /locus_tag="ctg61_1"
                     /transl_table=11
                     /translation="MVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     protocluster    1..10653
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1339:5653]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1340..5653
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10653
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10653
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             128..1276
                     /locus_tag="ctg61_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1340..2059
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg61_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2080..3381
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg61_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.4e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.5e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.8e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             3398..4522
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg61_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4532..5653
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg61_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg61_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.9e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4622..5629
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg61_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg61_6_Aminotran_5.1"
                     /locus_tag="ctg61_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5650..5793
                     /locus_tag="ctg61_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             5996..7480
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg61_8"
                     /sec_met_domain="Polysacc_synt (E-value: 1.7e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7434..8693
                     /locus_tag="ctg61_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8702..9451
                     /locus_tag="ctg61_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             9451..10491
                     /locus_tag="ctg61_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 attgtgcctg gtaaggctaa gaagaaaggg aacatagcta atattttagg ttatgctact
       61 tccttcagtt ctttgggaat gatgattgct tctattgcta atttgataaa gaaataaatg
      121 acctattatg attgaaaagc aatcttatca agaaccgttt tctgaagtgg ataaaaggaa
      181 agatgatgaa atggaaatag acttgatggc tattttttat aagattatta ctgttcgtgg
      241 agtactatgc aaagctgctg gagtgggagt aataattgct atagtggtgg cattgagcat
      301 tcccaagcaa tatacagtaa aggttaccct ttctcctgaa atgggtaatg cgaagggaag
      361 taatggttta gccggacttg ctgcctcgtt tttgggagat ggggctctaa taggggaaag
      421 cacagatgcc ttgaacgctt ctctttcagc agatattgtt tcttcaactc cttttttatt
      481 ggaactttta gaaatggaag tctccgtttc taaaaaggat gataaaatga ctttggggtc
      541 ttatctcgat gaagagtcat ctccttggtg ggattatctt ataggttttc cgggcatagt
      601 aataggagga gttaaatcat tattcggaga agatacggtt cctgccagtg gagggcggca
      661 aggaactatc gaattgacga aagaagtaaa tgagaagatt aattttctta aaaagaagat
      721 tagtgcatcc attgataaga aaaccgccat aacgagcatt acggtcacct tacaaaatcc
      781 gcagatcact gcggttatag cagattctgt cgttcataaa ttacaggaat atattattgg
      841 gtatcgaact tcaaaagtaa aagaagactg tgcgtatttg gaacggttgt ttaaagaacg
      901 tcagcaggaa tattatgctg ctcaaagaaa atatgcggat tatgtagacg cccatgataa
      961 tgtggttctt caaagtgtac gtgctgagca ggagcgttta cagaacgaca tgagtttggc
     1021 ttatcagata tatagtcagg ttgctaatca gttgcaggta tccagagcca aagtacagga
     1081 ggaaaagcca gtctttgcag tagttgagcc tgccgttgta cctttgaaac cttcaggtat
     1141 gggactcaaa atttatattt tattatttgt gttcctgtcc gtatctggta ctctcgtgtg
     1201 ggtgtttttt ggcaaaagtc tgctggctag cttgagaaaa gaactgaaaa ataaggagat
     1261 agaacaggat aaatgatgct aaaacgtcgt ttacaacatt cttacatcaa ttaaattcac
     1321 ttactatatt attaaacgaa tgatacgtac agctatgata atggctgcgg gcatgggaac
     1381 ccgttttggc caatatacag aattgatacc taaagggttc gtcaaagtgg gaggtattcc
     1441 aatgatagtt cgttctattg atactttgtt atcatgtgac attgagcgaa ttgtaatcgg
     1501 tacaggatat aaacaagaag tttatgaaga attgaagaca gactatccta tgcttgaaac
     1561 ctgttttagt cctcgttatg ctgaaacaaa tagtatgtat actttatata atacgcggga
     1621 gattctgggc aatgatgatt ttttattgtt agagtcagat ttgatttttg agaaacaagc
     1681 aataatgagc ttattggagt gtcctgcggc agatgcaatg ctaataactc cagtgacaaa
     1741 gtttcaagat cagtattatg tggaacatga tgataatttt cgcctttctt catgttctgt
     1801 caataagaat aaactaaacg ctaaaggcga attggtcggc atccataaac tatccggttc
     1861 cttttacaaa ataatgtgtg ctgattatgc gagtattgtt gatgaacaac ccaatttggg
     1921 atatgagtat gaattactac gaatatcttg ttctcaatct cctgtttatg tgcataaagt
     1981 agaagggctg aaatggtatg aaatcgatga catatcagat ttggaatatg cagagaaata
     2041 tattgttccg tattgttaat taaaataata tatcaaatta tgagtaagac agtttatatt
     2101 gggatgactg cggatattat gcatccagga cttatccgca ttattaatga ggctactaaa
     2161 tacggtgatg ttataattgg tcttcttaca gataaagcta ttgcggagca taaacgcctt
     2221 ccttatctga cctatgaaca acgaaaagag gtagttcaga atattaaagg cgtatgtaaa
     2281 gttgttcctc aagaagaatg gagctatgtt gagaatctca aacgcattaa acctgactat
     2341 ataattcatg gtgacgactg gaaaaccggg cctttacgtg aagaacgtgt gcgcgtattt
     2401 gaagtgatga atgaacaggg aggaaaggtt atcgaaattc catatacttt gggaattaat
     2461 tcatcttctt tggataaaga tattaaggct ataggtacaa cccctgatgt acgtttaaaa
     2521 tcacttcgtc gtttgataaa tgccaaaccc gtagttcgta ttttggaagc tcatgatgga
     2581 ctatgtggct tgataattga aaatcaggaa atattaaaag gggataagag ggaagtattt
     2641 gacggaatgt ggtctagtag ccttacggat tcaaccagta aaggtaaacc tgatattgag
     2701 gcggttgatt taactacccg attgcaagat ttgaataata ttctggagtg tactactaaa
     2761 cctattattt ttgatggaga tacaggtggt aaaattgaac atttcgtatt tacagtacgc
     2821 actttagaac gtcatggaat ttcagctata ataattgaag ataaagttgg attaaaaaag
     2881 aattcattgt ttggtacaga tgttattcaa actcaagata caatcgaagg tttctgtaat
     2941 aagatcaaag caggaaaggc atctcagatt actgatgatt ttatgattat cgctcgtatt
     3001 gagagcctta tagcgggaaa gccggtaagt gatgctttag agagagcttt tgcatatgtc
     3061 caagcgggag cggacggtat tatgatacat agcaaaaata agtcgggtga agatataaaa
     3121 gaattttgtt tggcgtttcg aaaacagtat gctcatgtac ctatcgtggt tgtgcctact
     3181 acatatgatc atatttatga gtctgaattg tgtgattggg gtgtgaatat aattatttat
     3241 gctaatcata tgcttcgtgc cgcttatcct gctatgatga atgtcgcaaa gataatatta
     3301 gagaatgaac gtgctttaga ggtgcgcgaa ctgtgtatgc ccataaaaga aatattggaa
     3361 ctgattccag gtactaaata aaaagaggaa tatcattatg ttaagcgtag aaaaagttta
     3421 tgaaacgttt ctgagtcatg acgttgattt ttttacagga gttccagact cattactaaa
     3481 aaatatttgt gcctatatca cagaccatac ttcacgtgag aaacatatca tagctgctaa
     3541 tgaaggtgcg gctgtaggaa ttgcttcagg ttattatatg gcatcaggta aggttcctgt
     3601 ggtttatatg caaaattccg gcttgggtaa tactgttaat cctctgctgt ctcttgcaga
     3661 tgaacaagta tacagttttc caatgctttt gatgattggc tggcgtggtg aaccgggaac
     3721 aaaagatgaa cctcagcata aaaaacaggg tgaggtaact ttagatttgt tgaaagcaat
     3781 gcggattcct tatataattc ttgattcaaa tgagaatgat gcatttattc agctccatga
     3841 tatcatacaa tcagcaaaaa ctaagaatat tcctcatgca ataattattc ggaaagatgt
     3901 ttttggcaaa tataaacttc aaaaagagtt cggatgtaat tatcctttat ctcgtgagga
     3961 tgctttgcaa atagttgtgg attatctgcc tgaaaattca gtggtcgttt ctactactgg
     4021 caagctttct cgtgagttat ttgaatatcg agaaatgaaa gagcaaggtc atgaacatga
     4081 ttttctcacg gtaggctcta tgggacatag ttcatcaatc tctttgggta ttgctatagc
     4141 aaagcaagat agacctgttt attgcttgga tggtgatgga gcatttatta tgcatttagg
     4201 ggcaattagt aacattggcg atttatctcc taaaaactat tatcatattt tgtttaacaa
     4261 tggtgctcac gagtctgtag gaggacagcc tactttagga tttagtttag atattccggc
     4321 tattgtccgg gggagcggat ataagcatac ttatactgtt tgtacaaaag ttgaaattga
     4381 agaagcaatg aagcagcttc caaagttatg tggtcctgtt ttgttggaaa taaaggttaa
     4441 aatagattct cgggagaatt tgggacgtcc cacgactact cctatagaga ataaggagca
     4501 ttttatggat tttttaaaat aaatatattc gatgaaaata gaaagaaaaa tattattaaa
     4561 tcctgggcct gccactacta ctgacagtgt aaaaatggca caagttgttc cggatatttg
     4621 tcctcgcgag aaagaattcg caggtatgat gaaacaactt cgggacgatt tggtcagagt
     4681 tgctcatggg aatttggaaa aacataccgc tgtattattt tgtggctcag gaaccatcaa
     4741 tattgatata tgtctaaatt ctcttcttcc tgaagacaaa agggtgctta tagtgaataa
     4801 tggggcatat agtacccgtg ctgtagaagt gtgtcaatat tatggtttgc ctcatattaa
     4861 tttggaattt tccgtttacg aacgtcctga tttatcggtg gtggaaaatg tgttgcaaga
     4921 aaatcctgat atagctatgg tttatactac tcatcacgag acgggtacag gaattctgaa
     4981 ccctattcgc gagatgggcg ctatagctca taaatatcag gctaaatttg tcgtcgatac
     5041 tacttcttct ttgggcatga ttccttttga tatagagaaa gataatgtgg atttttgtat
     5101 ggcatctgct caaaaaggac ttcaagcgat gacaggtctt tcttttatta taggcaatga
     5161 ggaacagatt aagttttcaa aaaaatatcc caagcgttct tactattgta atctttattt
     5221 gcagtatgag aattttgaga gaacaggtga aatgcatttt actccaccgg tacaaactat
     5281 ttacgccact cgtcaggcat taaatgaata ttttgaagtg ggtgaagaag ctaagtttgc
     5341 ccgtcacaaa agagtttttg aggctattca ttcaggtata aatgaaattg gtcttaaaag
     5401 tgtaataaag cgtgaatggc agtcaggact ggttgtctca gttcaatacc cagaagatcc
     5461 caactgggat tttgagaaaa tacatgatta ttgttatgag cgtggattta cgatttatcc
     5521 aggtaagata tcaactgagg atacttttag aatctgtgct ttaggagaga tagaagtaga
     5581 tgatattgag aacttcttta aagtactaaa agctgcatta aatcattata acgtcacatt
     5641 accgatgtca tgattgcaga aatattattg aagattcgtc atttttattt ttcccttcgt
     5701 ggtatacact tccatccgga aagtgttatt tctggagtgc ctattcgtag ctttcgctta
     5761 gtaggcaaat atggcaatat taatttgagg tgatgcatta ggagttcttt attcttataa
     5821 aaaggcatcg gtagttatag gagataatgt ttgtgtaggg taatttgctt ttagtgggag
     5881 agaccatatt agaattgcgg taaggggcga agaagataat aaccaattag tgagaatatt
     5941 ggaaaaatat aattgatatc ggtaaatgta gttgttttta tactgtattt aagtaatgga
     6001 aaatctaaag cagaaaactg tatcaggaat aatgtggagc gctatagaac gtttctcttt
     6061 acaaggagta cagtttataa ttcaaataat attagctcgt ttgttactac catcggatta
     6121 tggtatgatc gggatgttag ctatttttct tcaagtcgct caagtattta tagatagcgg
     6181 ttttacaaat gctttaatcc agaaaaaaga tagaactgaa gaggattttg ccactgtctt
     6241 ttattttaat attcttgtcg cagtattatt ctatggtata ttgttttttt cggcttcttt
     6301 gattgcagac ttttataata tgccgacttt agttcttgta attcgtttta tagcattgtc
     6361 gttgataata aatgctttat cggctattca cagaacgaaa ttaattattt ctgtaaactt
     6421 taaaactcaa tctaaaattt cattaggtgc agcttttata tcaggcgtga ttggaatatg
     6481 gatggcttat gtcggttgcg gggtttgggc tttagtttgg caaactctct taaatagtat
     6541 aattttgaca attttgtttt actgtttagt tcattggaaa cctttacata ctttctccaa
     6601 aagttctttt gaaagattat tcaatttcgg atctaaatta ttgatctcaa gtcttatcaa
     6661 tacagtatat cgtaatctgt ataccattgt aataggaaaa aagttttctg ttgtagagct
     6721 tggttactat acaagagcag aacaatttgc tatttttcct tccaataatt taaatgcttt
     6781 agtttctaga gtagcgtatc ctattttaag ttccattcaa gatgatgata aatgtttaac
     6841 aaacgcatat cgaaattata tcagattatc ctcatatata atttttcctt taatggtagg
     6901 tttacttgtt ttggctaatc ctattattag tctattgtta acagataaat ggtctggggt
     6961 tgttattctt ttacagatat tatgtttgga ttggatgttt gatcatttga gccaaattaa
     7021 tttgaattta ttatgggtta aaggaagatc tgatctgtcg ttacgtcttg aaataataaa
     7081 aaagacgatt gctatattca ttctttttgt gtcaattcca tttgggcttg aggtgatgtg
     7141 ttggggtaga gttatttact ctctgatagc gacatatttg aatacatatt atactaattc
     7201 tcttattgat ttgaccttaa agttgcaagt taaagatgta tttccaagtt taatactctc
     7261 tttcataatg ggggggatcg tttttatatg tatttctttc tttgaaactg atatagtaaa
     7321 aattgtgatt ggatgtatta ctgggatgtc cttctatatt ttactttctt ttctttttaa
     7381 gctagattct tttttttgta ttttaacatt gatcattaaa actaaaaaca tagatgaaaa
     7441 tattaaaaaa gatttttcaa gtaatagtaa agataattaa ccattgtgtg ccagttgata
     7501 gtagatcatt gtattttatt cctcatccta attgtagaac agataaatat gatattataa
     7561 attattcgtc agataatgtt ctcgttctgt taaattattt gctaaaaaaa gatagtgctg
     7621 aatattataa aatatatgtt gaaatttatg attcttctcg tatttcagaa tatcaagaat
     7681 atatttatgg cataaatcct aatattaggt gtactttttt atgtgcatgt gttggacgtt
     7741 ttttctttaa taaagtatct tttaaggata tgttgtatgc ctttttttgt ttttgtagag
     7801 caagtaaatg ttttacagct actttttatt atgatttttc atttaaaaaa cgctctcaac
     7861 agattatttg tttggggtat tatactccat tcaaagatga ttatcatatg ggagatcatt
     7921 cttatgataa atttcgtaat acaacatgta actcatttga ttactctatt gctacttctt
     7981 gtttaagtgc tagaataatt tcaatagatt gtggaatctc atatgataaa ttcaaagtct
     8041 taggatttcc cagaaatgat ttgttgatat cgaaaaataa ttgcaatgtt attaaaagag
     8101 aaatttcgaa atttgcggga tatgatgtaa ctaaatatat agtttatact ccaacttttc
     8161 gtgattatga gactgttact gaaggtaatt tgcgttcaat actcggatat gttgattgtg
     8221 atttgttgaa gttatcgaaa atactattga agtttaatgc ggctttaatt cttaaattac
     8281 atcctttgca gaataaaaca gtcttaaaaa aagatttacc caaaggtata cttgtttttg
     8341 aacaaacata taaatatgga ttgtatgatc ttttgtcatt ttcagatgga atgattactg
     8401 attatacttc tacctatttt gattttttat tggtaaataa gccagtcata tttaatttct
     8461 acgatattga agaatatcgt agagtaagag gtttctcatt tgagccaata gaattttttt
     8521 gtgcaggtga tattgtttac aattataatg aattgataga tgctgtgatg ggacttctgg
     8581 ctgggaaaga tattcatgct gaacatcgac gtcatatttc tttattgatg aatcaatttc
     8641 aagatgataa ttcaacaaag agaatatgtg acatattttt aaatgaaata taataaataa
     8701 aatgaattat gcatttgtgg tgcaggcacg tttaggttct acacgtttgc ctggaaaaat
     8761 attgaaacct ttctatggta atcaatcgat tcttgactta atggttcata agctttctgc
     8821 tatatcgaat attccagtaa ttattgctac aacaaattct gttatcaatg aacctattga
     8881 aaagaaggca cttgcattag gggtaaagtg cttcagaggt gaggagaatg atgttttaaa
     8941 acgattcatt gatgttgctg aatattttga tatacagggt atattccgaa tatgttctga
     9001 taatccattt ttagatgtac atgcggcaag gcaattggtc gaaatagcaa tgaaatcttg
     9061 taacgattat ataagttttg atattgatgg tactccatca attaaaactc atttcggttt
     9121 ttggggagaa tttgtaacgc ttgatgcgct gaagcgagtt ataggattta ctgatgattt
     9181 attgtatcgt gaacatgtta ctaattatat atatagtcat cctgaacttt ttaatattca
     9241 atggatttca ggatctccag tcgtgtcaaa acatcataat attcgactca cgattgatac
     9301 gttagaagat ttttctgtag cacagagaat atatagggat ttacaagaaa aaagagtgga
     9361 aatatcgata gaagtgattg tagactatgt tcgaagacat gcagaataca ttcaactgat
     9421 gaaacaacaa ataaaaaaaa attctaaata atgaagaata cttatattat tggtgaaata
     9481 gggcagaatc ataatggttc tgttgacttg gctaagttga ttattgaatt aatctcacga
     9541 cctgtacatg aggatgtttt tggtatggat ttcatgccaa tgaatgctgt taaaatgact
     9601 aaaagagatt tatcagaaga attggctgtt tctcaaatga atcaaatata tgacaatcct
     9661 aattcttttg ggcgtactta tggtgaacat cgtgcttttc ttgagcttga tgatcaagcg
     9721 cattttgaga tttataaata tgctaagtca ttaggattag attttatcga gacgttatgt
     9781 gccaaaggat gtctgtcttt gcttaaactg ttcacaccgg ataggctaaa agttgctagt
     9841 cgtgatttga ctaacttacc attgcttgaa gcattagcag aaactcatat tcctattata
     9901 ttatcgacag gaatggctgg tcaaagagaa cttgacaatg cattagatgt gataacgaga
     9961 tatcatagta atatagctat tctacattgt gtatctcagt atccaactca tccaaataat
    10021 ttgaatctac gtacaataac atatttgaag aagcattaca ataagtttga gataggtttt
    10081 tctgatcata caataggtat ttctgctgct acagctgctg tagcgatggg agcggaaatt
    10141 atagaaaagc atgtaacaat tgatcggcat atgaaaggaa cagaccagct tggctcttta
    10201 ggtccagatg gggttaatcg tatgattcga gatattcgca tagcagagtg ttggcttggt
    10261 actgaagatc tttatataga aaaaggggtg gagaagtcta agataaaact tgaacgttct
    10321 attgccactc gaaaatatat tccagcaggt agtattattc aagagtcgga cattcattta
    10381 ctgagtcctg gtgatggtta taaatggata gataaaaaaa atgtaattgg tcattttgct
    10441 aaacaagata tatcagcgaa tgaaataata tatcctgatt ttattgaata gatatattcc
    10501 tactgcaact tgtattacgg tatagagtac tgcctgctat aagctaagta gtgattaata
    10561 aataagggta aaatactaaa aaaatgaaag agataaagct tatacttaca gatattgatg
    10621 gcgtttggac tgatggcgga atgttttatg atc
//
