LOCUS       gnlProkkaJHGIFEFG_100  14897 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JHGIFEFG_100.
ACCESSION   gnlProkkaJHGIFEFG_100
VERSION     gnlProkkaJHGIFEFG_100
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 06:40:50
            Original ID  :: gnl|Prokka|JHGIFEFG_100
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14897
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14897
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1245:9897]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1246..9897
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14897
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14897
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             2..70
                     /locus_tag="ctg100_1"
                     /transl_table=11
                     /translation="MRIFCDDLLTEKVKQILCEKGG"
     CDS             315..1253
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg100_2"
                     /sec_met_domain="APH (E-value: 7.5e-10, bitscore: 29.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKLKQDKLLDEEALTVICEALHVNNQDITDIDIMKKGMTNRSFT
                     FRCKGKRYMIRISGVGTEKLIDRCQEKEVYEAIRDMDICDPVIYIDSEKGYKISEFLEN
                     SRVCDPMNGLDVKRSMECLKRFHDKKLAVGHTFDLFGQIEKYELLRGNSKSVYADYEKT
                     KRDVYWLKSFIDRNIEEKVLTHIDAVPDNFLFVKDEYGKEQIKLIDWEYAGMQDPHVDI
                     AMFGIYSLYDREHMEQLIDAYFPEGCSKRIRTKIYCYIAVGGLLWSNWCEYKEKLGNSF
                     MEYATHQYQYAKEYSYIALLKLQEMERTLHA"
     CDS             1246..1767
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 8.6e-16, bitscore:
                     49.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHKVERAIILAAGIGKRMNPVTLGTPKPLVKVNGVRMIDTIIKAL
                     YQNDITEIYIVVGYLKEQFCEIRKEYQGITLIENPYYATCNNISSLYVARKYLENAIIL
                     DGDQIICNERILISEFCRSGYNSVWTFEETDEWLQTVKDGIVTACSRVGGDVDGNCIAF
                     RVGQLRMEEN"
     CDS             1833..1970
                     /locus_tag="ctg100_4"
                     /transl_table=11
                     /translation="MFCHSQEYQLGIFEMQPDDVIEIDSLEELISIDNNYVKYREKGLA
                     "
     CDS             1967..3508
                     /locus_tag="ctg100_5"
                     /transl_table=11
                     /translation="MKKKEREQIDWLITIVPFLLIISLFVLFIILPEQSNYILGRIRFF
                     LGDTFGSYYIMIGIVFFCVSIYLAGSKYGNIILGTQGEKPKNSFFSWGAMMFTCGLAAD
                     ILFYSFSEWMMYASDPHIIELGNIQKWAGIYPLFHWSFIPWSFYLVLAVAFGFMLHVRN
                     RERQKYSEACRPILGKQTDGIGGRMIDLLAVFVLIAGTATTFGIATPLISEILTDVFQI
                     QLERTALNLIILIITCLIYTYSLLHGFHGISFLAKICIYMFFGILLYVLLFGGKTRYII
                     ESGISSLGIMMQNFISLATDTDPLRTSYFPQNWTIYYWAYWMVWCVASPFFIGRISKGR
                     SIRQVILGGYMFGAGSTMVSFIVLGNYSMEMQMSGTVDYVGEYNRTGDLYHIIVSIIKT
                     LPGATIVLLAVVFTMIAFYATSFDSIALIASCYSYRKLDGQKQPHKVVQLIWCILLILF
                     PIALLFTNSSMSNLQSVSIIAAFPIGMVMILIVISFFKDVEKYKKDLDNSQKQTK"
     CDS             3553..5583
                     /locus_tag="ctg100_6"
                     /transl_table=11
                     /translation="MVTRCVMKNDKKEKIWDLFDQKENANDIQTMILEYENEFSDDMDI
                     FLMKMCLFIYENKIQAAIEIGKQALRKNPYLLEIHLKLAEAYKDQSKYIEAYKHYCISK
                     LLASFAGEEKICRDCELLAKGSLEQLEELITYLPDEQKIYLSQKMIPAFLGYEKNQFGY
                     NERRFRTFEHIGGDYYYESEEVKKYVGMYHRPRHVINELDAVHWKIEFQEVVEANYLKL
                     PDTEKKWIVPVAVEKNTTHWFETDNGKMPVIQRDIKSFYYYRVGGGREIISSDICYWGN
                     PIPIKSDKNKKRLVLSIFVDGLAQVLLTADKFAYLMPNTAKFFKNGMVCKQAYSSGEWT
                     YPSIAGVMSGLATTQHMMFHNEIDWKLPNSVKTLMEYFHESGYYTSAFSGDWRIIPSYG
                     YARGCDRFIYQLQHTGFSVEKMIGGVINEIDALKEINQFVWVSLGDLHDVADEMELPTS
                     VQTHLKIEDRVCEKGSETSVKQKYDMAKKIQYEQMLQYMDRYLGMLFSYLENTYEENEL
                     IVALFSDHGQGFLIPEDGQFLGPERTNIAFMFRNGQLKGETEEVMSSLDYTAILCKMAG
                     IAYCEQGVEGRTPRIFGGSGRRWALTESLHPKDYYRAALVSENYRFYFCNPIPVGYDGR
                     FEIGDYSICLTDKEGRNVYAEDVEKECLDIIMRQIANLCIY"
     CDS             5624..6748
                     /NRPS_PKS="Domain: Aminotran_5 (25-292). E-value: 4.3e-39.
                     Score: 126.3. Matches aSDomain:
                     nrpspksdomains_ctg100_7_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 84.9; E-value:
                     8.7e-26)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_7"
                     /sec_met_domain="Aminotran_5 (E-value: 7.4e-38, bitscore:
                     121.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRNILLNPGPATTTDTVKQAQVVPDICPREQEFVEIMKQIRKDL
                     VKIVHGDEQDDTSVLFCGSGTISMDVCLNSLLPEEKKILIINNGAYSSRAVEICEYYGM
                     PFINLEFPIDERPSLELIEQVLKENNDIALVYTTHNETGTGILNPVREIGALVHRYGAV
                     FVVDTTSTYAMRPIDIKKDNIDFCMASAQKGLMAMTGVSFVIGNKSIIERSKDYPKRSY
                     YCNLYLQYDYFEKHGEMHFTPPVQTVYAMRQAIAEYFAEGEQEKWKRHTRVYDALYSGL
                     ERLGFQNVIKKEWQAGLVAAVKYPDDPNWSFSAIHDFCYERGFTIYPGKINNTETFRLC
                     ALGAIDETDIEDFFEIFEEGLKQMGVSLPVYYQK"
     aSDomain        5699..6499
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg100_7_Aminotran_5.1"
                     /evalue="4.30E-39"
                     /label="ctg100_7_Aminotran_5.1"
                     /locus_tag="ctg100_7"
                     /protein_end="292"
                     /protein_start="25"
                     /score="126.3"
                     /tool="antismash"
                     /translation="DICPREQEFVEIMKQIRKDLVKIVHGDEQDDTSVLFCGSGTISMD
                     VCLNSLLPEEKKILIINNGAYSSRAVEICEYYGMPFINLEFPIDERPSLELIEQVLKEN
                     NDIALVYTTHNETGTGILNPVREIGALVHRYGAVFVVDTTSTYAMRPIDIKKDNIDFCM
                     ASAQKGLMAMTGVSFVIGNKSIIERSKDYPKRSYYCNLYLQYDYFEKHGEMHFTPPVQT
                     VYAMRQAIAEYFAEGEQEKWKRHTRVYDALYSGLERLGFQNVIKK"
     CDS             6767..7054
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_8"
                     /sec_met_domain="NTP_transf_3 (E-value: 2e-13, bitscore:
                     41.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKEKDEIAILMAAGLGTRMRPLTEQIPKPLVPVMGTPLIETVIC
                     ALERRGIKRIYVVVGYLKEQFSYLLEKYDNLEIVENKEYLKKTIFRHCMQ"
     CDS             7042..7479
                     /locus_tag="ctg100_9"
                     /transl_table=11
                     /translation="MYAVRDILGSSDCFICEADLYVPDDTIFLRQYSTSCYFGKMIEGY
                     SSDWVFDVQNGNITRVGKGGTDTYNMAGISYWKRSDALIIKKAIEASYKKPGHEKLFWD
                     EIVDQELKRLKVQVEEISPESVIEVDTLEELSQLDSRYKTC"
     CDS             7473..8606
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 46.8;
                     E-value: 3.1e-14)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_10"
                     /sec_met_domain="TPP_enzyme_N (E-value: 3e-22, bitscore:
                     69.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.2e-15, bitscore:
                     47.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVTDFVEQIKKIGIKTLAGVPDSALKSFCDYINGTGKNEFEHYV
                     PVNEGAAVGIAIGSYLATGVPACVYMQNSGLGNIVNPITSLANKDVYGIPMLLLVGWRG
                     EPGTKDEPQHKYMGKITEDLLRVLEIEYIVLEKELSMQEIMRSFERAAQVLKEGKQFAF
                     VLKRDFLQNNNSSDYKNNNSLVREDAIAAIIKMLDESDVVISTTGKISREVYEQSDRIK
                     GSHAQDFLTVGGMGHASMIALGMAHKLEKKRVYCLDGDGAVLMHMGSMAYIAKQKPQNL
                     IHICLNNDAHESVGGMPTGCVGLSYADIAGTVGYERVYCVDKQQDLTKVLSDIKKKRNL
                     TFIEIKVAMQSRADLGRPKETAEENKNNFMKYHGVGL"
     CDS             8603..8692
                     /locus_tag="ctg100_11"
                     /transl_table=11
                     /translation="MKKVYACFCTDVIHEGHLNIIREAKNMEN"
     CDS             8689..9897
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 206.2;
                     E-value: 1e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_12"
                     /sec_met_domain="CTP_transf_like (E-value: 2.3e-09,
                     bitscore: 28.4, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.3e-117, bitscore:
                     381.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 7e-66, bitscore:
                     212.9, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAGVLSDTAMIRYNRFPTVSFEERKKMLEQIPEVDEVVVQDEVM
                     YGSILERIKPDYVIHGDNWLNDPMEVIRDNVIENLKKWGGQLIEIPYTYNEQVRNIEAV
                     MRERTAMPEYRRKRLRQLLQLCPIVKTLEVHSGLTGLIAEKTVVANNGEIDQFDAMWLS
                     SLCDSTAKGKPDIELVDMSSRLRTVDDVLEVTTKPIILDGDTGGMIEHFVYNVRTLERV
                     GVSAVIIEDKTGLKKNSLFGTEVEQTQDSIENFTAKIRAGKRAQRTKDFMIIARIESLI
                     LEKGLEDALVRAFAYVDAGADGIMIHSRKKTPDEIFAFCDRFREKDKITPLVVVPTSYN
                     ETYESELQQHGINIVIYANQLTRSAFPAMQQTATDILRYHRAKEVDDRLMSIKDIITLV
                     DEV"
     CDS             complement(10045..11058)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg100_13"
                     /sec_met_domain="Glycos_transf_2 (E-value: 8.2e-34,
                     bitscore: 107.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVSVIIPCFNATKYLPKCFMSLVQQTIGIDQIELIFVDDASTD
                     EDATWNMLQEFERAYPESIMILKLEENMRQGGARNVALQYATGEYIAFVDADDFVAENF
                     LLETYEKAKESDADIIQFEYFYYTDRLGAVDSGRNIMPEVIEISSVNDRKEFLISEKIT
                     YGCWNKLYRHDLLKTAHTAYAEHVIYEEPLFVYPLLYFANKIVILNDAYYYYRQNDSGT
                     MRNDMRQEETLKMHADVQLAVWNFMKNTPFFQEYYDEIKLYFLHTYLYETLYFAKLRDF
                     KPSYSFYKELEKTVFTEVPDYSQSVYSALIPKQLELYRMIEEGMTEEKFGGYCERL"
     CDS             11389..12891
                     /locus_tag="ctg100_14"
                     /transl_table=11
                     /translation="MFEHLAIWKEEKYRELQGTYPVISLSFARIKERDYEKTKQKMCEV
                     LRNIYIKFCYIKDSEKLTDADRAYYERMLEENIKETDATSSLYQLSDFLYRYYGKKVII
                     LLDEYDTPMQEAFVDGYWDELVAFTRSLFNSTFKTNPALERGIMTGITRVSKESVFSDL
                     NNLKIVTTTSNEYASVFGFTEKEVFDALEQYGLEKEKKEVKRWYDGFIFGEHKDIYNPW
                     SILNYLDTQLYKTFWANTSANSLVGKLIQEGNRTIKEKFEKLLCGEYIWSEIEEQIVYN
                     QLNGNEKAVWSLLLASGYLKVLSYETYQDIEEGKMPKYQLALTNLEVKLMFQGMVHDWF
                     APVQPDYNDFVRAMLLGDVDAMNEYMNRIAIQTFSYFDTGERASGAEPERFYHGFILGL
                     LVDLRDRYYLKSNRESGFGRYDVMLEPKNSKECKAVILEFKVRNPRKEKSIQETVLSAL
                     KQICEKKYDADLLDKGIRKEQIYHYGFAFEGKKVLIGTDREE"
     CDS             12936..14087
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg100_15"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2e-24, bitscore:
                     77.1, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVCIITKNEEHNLARCLKSFQNTGFELVVVDTGSTDQTKKIAA
                     EYTENIYDFPWCDDFSAAKNFAVSKATHPYVMVIDSDEYLQKIDLSRLEKMIVEHPGEV
                     GRIQRINIISGKDGKQENKEWINRIFAKESFHYTGRIHEQVTAYDEKEYRTYEAPVLIG
                     HTGYDLPKKEKKAKALRNIRLLEQELKNSGWDAKVHATQLEQNLSKQDTDAEQKSEIAD
                     AKKEQQIPYLLYQLGKSYYMAEDYDEACFWFAHGLSYDLEPKLEYVIDMVETYGYALIN
                     SGRAGEALFFENIYEEFGNSADFQFLMGLIYMNNAMFDAAVGEFLKAVRHRDCRMAGVN
                     SYAAYYNVGVIYECLGKISDAKYYYQKCGGYEPAKKRLRLINS"
ORIGIN
        1 aaaccggatt ttttgcgatg atctgctaac agaaaaagtg aaacagattt tatgtgaaaa
       61 aggcggatag aaaatcagca gaaaaaatat atagggaaaa agcaggggga attttgcgcg
      121 tattgactag gaacgaaggg taaccgcaga tggaatgctg ataactggat tatttataaa
      181 aatgcataga taaaaaagtt aaaagcgaaa tccctgttta tctggttgtt tcattgtaca
      241 atagcctcct atctgttata attgtatcat aaagtaaaat tacagaaaag gcttatttgc
      301 atataggaga cgatatgtta aagttaaaac aggataaatt attggatgaa gaagcactta
      361 cagtaatttg tgaagcactt catgttaaca accaagatat tacagatata gatattatga
      421 aaaagggaat gacgaatcgg tcatttacat ttcgatgtaa aggcaaacgt tatatgatac
      481 gaatttcagg agttggtaca gaaaaactga ttgatcggtg tcaggaaaaa gaggtatatg
      541 aagcaatccg tgatatggat atttgtgatc cggtcattta tatagattct gaaaaaggat
      601 ataaaatatc ggagtttttg gaaaattcgc gggtatgtga tccgatgaat ggtttggatg
      661 taaaaagaag catggaatgc ctgaaaagat ttcatgacaa aaagttagct gtcggccata
      721 cgtttgatct ttttggtcag attgaaaagt atgagttgct tcggggaaat tcaaaatctg
      781 tctatgcaga ctatgaaaaa acaaagaggg atgtttactg gttaaaatca tttattgatc
      841 gcaatataga agaaaaggta ctgacacata ttgatgcagt tccagataat ttcttgtttg
      901 taaaagatga gtacggaaaa gaacagatta agttgattga ttgggaatat gcaggaatgc
      961 aggatccaca tgtggatatc gctatgtttg gtatttattc attatatgac agagaacata
     1021 tggaacaatt gattgatgct tattttccag agggctgttc gaaaagaatc agaacaaaga
     1081 tttattgtta tattgcagtg ggtggtcttt tgtggagtaa ttggtgtgaa tataaagaaa
     1141 aattgggaaa tagttttatg gagtatgcaa cccatcagta tcagtatgca aaagagtatt
     1201 cttatattgc actgttgaaa ttgcaggaaa tggagagaac attacatgca taaagtagaa
     1261 cgtgccataa tcctggcagc cggaatagga aaaagaatga accccgttac attaggaacg
     1321 cccaaacctt tggtaaaggt aaatggagtt agaatgattg atacgataat aaaggcactg
     1381 tatcagaatg atattacaga gatttatatt gtagtaggat atttaaaaga gcaattttgt
     1441 gagatacgga aggagtatca ggggataaca ttgattgaga atccatatta tgcaacatgc
     1501 aataacattt catcattgta tgttgcgcgg aaatatcttg aaaatgcaat tattctagat
     1561 ggagatcaga tcatatgtaa tgagagaatt ttgatatcgg agttttgccg gtcggggtat
     1621 aatagtgtat ggacatttga agagacggat gagtggcttc agacagtgaa agatggaatt
     1681 gtgacagctt gtagcagagt tgggggggat gtggatggca actgtatagc atttcgcgtt
     1741 ggacagctga ggatggaaga aaactaaaaa aacatctgga actcgagttt gaacaaaagc
     1801 acaacacaca aatatattgg gatgatattg ttatgttctg tcattcacag gagtatcagc
     1861 ttggtatttt tgaaatgcag ccagatgatg tgatagagat agatagttta gaagagctga
     1921 taagcataga taataactat gtgaaatata gggaaaaggg actagcatga aaaaaaaaga
     1981 acgtgaacaa attgattggt taattacaat cgtgccattt ttattaatca ttagtttatt
     2041 cgtattattt atcatattgc cagagcaatc taattatatt cttggtcgga tacgattttt
     2101 cttaggagat acttttggaa gttattatat tatgataggg atagtttttt tttgtgtttc
     2161 catctatctt gcgggctcaa aatatggaaa tattattttg ggaacacagg gagaaaaacc
     2221 taaaaattct tttttttcat ggggagcaat gatgtttacc tgcggattgg cagcagacat
     2281 tttattttat tctttttcag aatggatgat gtatgcatca gatccacata tcatagaact
     2341 aggaaacatt cagaaatggg ctggtatata tccactgttt cattggagtt ttattccatg
     2401 gagtttttat ttggtgcttg cagtggcatt tggttttatg ttacatgttc gaaatagaga
     2461 acgtcaaaaa tattcagaag catgcagacc aatattagga aaacaaaccg atggcattgg
     2521 tggaagaatg atagatctat tggcagtatt tgtattgatt gctggtacag caacaacatt
     2581 tggtattgcc acaccgctta tatcagaaat tttaacggat gtttttcaga tacagttaga
     2641 gcgtacagcc ttgaacttga tcattctgat tatcacatgt ttaatttata catattcttt
     2701 acttcatgga tttcatggaa tcagtttcct tgcaaaaatc tgcatttaca tgtttttcgg
     2761 aatcttattg tatgtattat tatttggtgg aaaaacccga tatattattg aaagtgggat
     2821 atcttctttg ggtatcatga tgcagaattt cataagttta gctactgata cagacccgtt
     2881 aaggacatct tattttcctc agaattggac aatttattat tgggcttatt ggatggtatg
     2941 gtgtgtagct tccccgtttt ttattggaag aatttcaaag ggcaggagca tacggcaggt
     3001 aattctgggt ggatatatgt ttggtgcggg gtctactatg gtaagcttta tcgttttagg
     3061 aaattattca atggaaatgc agatgtctgg gacggtagat tatgtgggtg aatataatcg
     3121 gacaggagat ttatatcata taatcgtaag cattattaaa acacttccgg gtgcaacaat
     3181 agtactgttg gcagtggtat ttacgatgat tgcattttat gcgacatcat ttgattcaat
     3241 tgcattgata gcttcttgtt atagctatcg taaattggat gggcagaagc agccacataa
     3301 agttgtgcag ctgatatggt gtattttatt gattctgttt ccgattgctt tgttattcac
     3361 aaatagttct atgagtaacc tgcaatcggt aagcattatt gcagcatttc caattggtat
     3421 ggtaatgatt ttgattgtaa taagtttctt taaagacgtt gagaagtata aaaaagatct
     3481 tgacaatagt caaaagcaaa caaaataaat tgaaaatgaa atatttgatt agctggaaga
     3541 ggaagaaaaa taatggtgac aagatgtgtt atgaaaaatg acaagaagga aaagatatgg
     3601 gatttatttg accaaaaaga aaatgcaaat gatatacaaa caatgatttt agaatatgaa
     3661 aatgaatttt ctgatgacat ggatatcttt ctgatgaaaa tgtgcctttt tatctatgag
     3721 aataaaatac aggcagcaat tgaaatcgga aaacaggcat taagaaagaa cccatattta
     3781 ttagaaatcc atcttaaact ggcagaagca tataaggatc aatcaaagta tattgaagcg
     3841 tataagcatt attgtatatc caaattatta gcgtcatttg caggagaaga gaaaatatgc
     3901 agagattgcg aattattagc aaaaggttcg ttagaacagt tggaagaact aatcacttat
     3961 ttacctgatg aacagaagat atatttgtct caaaaaatga taccagcatt tcttggttat
     4021 gaaaaaaatc aatttggata taatgagcgg cgttttagga cgtttgagca tattggtggc
     4081 gattattatt atgagagtga agaagtaaaa aaatatgttg gaatgtatca tagacctagg
     4141 catgtaataa atgaactgga tgcagtgcac tggaaaatag aatttcagga agttgtagag
     4201 gcaaattact tgaaactccc tgatacagag aaaaaatgga ttgttccagt agcggtggaa
     4261 aaaaatacta cccattggtt tgaaacagat aatgggaaaa tgccagttat tcagcgagac
     4321 attaaaagct tttattatta tagagtcgga ggcggcaggg aaataatatc ttcggatata
     4381 tgttattggg gaaatccaat accgattaaa agtgataaaa ataagaaaag attggtgtta
     4441 agtatatttg ttgatggtct ggcacaggta ttgctgacag cagataaatt tgcataccta
     4501 atgcctaata ctgcaaaatt tttcaaaaat ggaatggttt gtaaacaggc ttacagttct
     4561 ggggaatgga catatccgag tatagctgga gttatgtcag gacttgcaac aacccaacat
     4621 atgatgtttc ataatgaaat tgattggaaa cttccaaatt cagttaaaac actgatggaa
     4681 tattttcatg agtcgggata ctatacatct gctttttcag gcgattggag aataatccca
     4741 tcatatgggt acgcaagggg atgtgaccga tttatttatc aattgcaaca cacagggttt
     4801 tcagtcgaaa aaatgattgg cggtgttatc aatgaaatag atgcattaaa agagattaat
     4861 cagtttgtgt gggtatcgtt aggggattta catgatgttg ctgatgaaat ggaattacca
     4921 accagcgtgc agacgcattt gaaaatagaa gatcgcgtat gcgaaaaagg aagcgagaca
     4981 tctgtaaaac aaaaatatga tatggctaaa aaaattcaat atgaacagat gttacaatat
     5041 atggatcgtt atttgggaat gttattttca tatttggaga atacatatga agaaaatgaa
     5101 cttatagtgg cattgttttc agaccatgga caaggatttt tgataccgga ggatgggcag
     5161 tttttaggac cggaaagaac aaatatagca tttatgtttc gaaatggaca acttaaaggc
     5221 gaaacagagg aagttatgtc atctttggat tatacggcaa ttttatgtaa gatggcggga
     5281 atagcatatt gtgaacaggg ggttgaggga cgaactccaa gaatatttgg tggaagtgga
     5341 agaagatggg cgttaacaga gagtttgcat ccaaaagatt attatagagc ggcactggta
     5401 agcgaaaact atcgatttta tttttgcaac ccgattccgg ttggatatga tggaagattt
     5461 gagattggag attattcaat ttgtcttaca gataaagaag gaagaaatgt ttatgctgaa
     5521 gatgttgaaa aggaatgctt agatattatt atgaggcaga tagcaaatct gtgtatttat
     5581 taaatggcgc gttgagattt gatgtataat gggagagaga actatgaaac gaaatatatt
     5641 gttaaatccg ggaccggcta cgacaaccga tacagtaaaa caggcacagg tagtgccgga
     5701 tatctgcccg agggaacagg aatttgttga aattatgaag cagatacgaa aagatctagt
     5761 taaaattgtg catggagatg agcaggatga tacatctgta ttgttttgtg gttcgggtac
     5821 gatttctatg gatgtctgtt taaattcatt attgccggaa gagaagaaaa ttctgatcat
     5881 taataatgga gcatatagtt ccagagcggt agagatatgt gaatattatg gaatgccgtt
     5941 cattaatctg gagttcccaa tagatgaaag accatcatta gagctgatag aacaggtact
     6001 aaaagaaaat aacgatatag cacttgtata tacaacacat aatgaaacag gaacaggtat
     6061 cttaaatccg gtgcgggaaa tcggagcact tgtacatcgg tatggagcgg tttttgtggt
     6121 agatactaca tcgacatatg cgatgaggcc gattgatatt aagaaggata atattgactt
     6181 ctgtatggca tctgcgcaaa aaggattaat ggcgatgaca ggtgtatcat ttgtgattgg
     6241 taataaaagc ataatagaga ggtcaaaaga ttatcccaaa cgttcctatt attgcaattt
     6301 gtatttacaa tatgactatt tcgaaaaaca tggagaaatg cactttacgc cgccagtaca
     6361 gacagtttat gcaatgcgtc aggcaatagc agagtatttt gcggaaggag agcaggaaaa
     6421 gtggaagcgc cataccagag tatatgatgc attgtacagt ggccttgaac gactgggctt
     6481 tcagaatgtg ataaagaagg aatggcaggc gggactggtg gctgcagtga aatatcctga
     6541 tgatccaaac tggagttttt ctgccatcca tgatttctgc tatgagagag gttttaccat
     6601 ttatccgggt aaaattaata atacggagac atttcgctta tgtgcgttag gtgctattga
     6661 cgaaactgat attgaagact tctttgaaat atttgaagaa ggattaaagc agatgggagt
     6721 ttctttgcca gtgtattacc agaaatgagg aacggatatt taaaatatgt tgaaagaaaa
     6781 agatgagata gctattttaa tggctgcagg attaggtaca agaatgcgcc cgctgacaga
     6841 gcagattcct aagccacttg ttcctgttat gggaacacct ctgatagaaa cggttatttg
     6901 cgctttagaa cggcggggaa taaaaagaat atatgttgtt gttggttatt taaaagaaca
     6961 attttcttat ttgttagaaa aatatgataa cttagagatt gttgaaaata aagaatattt
     7021 gaaaaaaaca atatttcgtc attgtatgca gtgagagaca ttcttggaag ttcagattgt
     7081 tttatttgtg aagctgattt gtatgtgccc gatgatacta tttttttgag acaatattca
     7141 acttcgtgtt attttggaaa aatgatagag ggctattctt cggactgggt attcgatgtg
     7201 caaaatggta atattacaag agtaggaaaa ggcggtacag acacatataa catggcaggt
     7261 atttcttatt ggaaaaggtc agatgcgtta atcataaaaa aagcaattga agcatcatat
     7321 aagaaaccag gacatgagaa attattttgg gatgagattg ttgatcagga attaaaacgt
     7381 ttaaaggttc aggtagagga aatatcaccg gaaagtgtaa tagaagttga tacactggag
     7441 gaattgagcc agctggattc gaggtataag acatgttagt aacagatttt gttgagcaaa
     7501 taaaaaaaat aggaataaaa acattagccg gggtgcctga ttctgcatta aagtcttttt
     7561 gtgattatat caatgggaca gggaaaaatg aatttgaaca ttatgtgccg gtaaatgaag
     7621 gggcagctgt tggcattgcg attgggagtt atttggcaac tggagtacca gcctgcgttt
     7681 atatgcagaa tagtgggctg ggaaatatag taaatccaat tacatcgctt gctaataaag
     7741 atgtatatgg cataccaatg ttattattag tgggatggcg cggtgagcca ggaacgaaag
     7801 atgaacctca gcataaatat atggggaaaa taacggaaga cttactgcgt gtgttggaaa
     7861 tcgaatatat agtgttggaa aaggaacttt ctatgcagga aataatgcgt agttttgaaa
     7921 gagcagcaca agtgttaaaa gaaggaaaac aattcgcatt tgttttgaaa agagactttc
     7981 tacagaataa taacagtagt gattataaaa acaataatag tttagtaaga gaagatgcaa
     8041 tagcggcaat aataaaaatg ttggatgaaa gtgatgtcgt catttctaca acaggaaaga
     8101 tttcaagaga agtatatgag cagagtgata gaataaaagg gagtcatgca caggatttcc
     8161 tgacggtagg gggaatggga catgcatcta tgatcgcact tggaatggct cacaaattag
     8221 agaaaaaaag ggtgtattgt ctggatggag atggagcagt gcttatgcat atgggaagta
     8281 tggcatatat agcaaaacag aaaccgcaaa atttgatcca tatttgtctg aataatgacg
     8341 cacatgaatc ggtaggggga atgccgactg gttgtgtggg attaagctat gcagatattg
     8401 ccgggaccgt tgggtatgaa agggtgtatt gcgtggataa gcagcaggat ttaacaaagg
     8461 tgttgagtga cataaaaaag aaaaggaatc ttacattcat tgagataaag gtggcaatgc
     8521 aatcgagggc agatctgggg agaccaaagg aaactgcaga agaaaataaa aataatttta
     8581 tgaaatatca tggggttggc ttatgaaaaa agtatatgct tgtttttgca cggacgtaat
     8641 acatgaagga cacctgaata ttattcggga agcaaaaaat atggaaaatt gattgcaggt
     8701 gtattgagtg atactgcaat gattcgatat aaccgctttc cgacggtatc atttgaagaa
     8761 cgaaaaaaaa tgttagaaca gataccggaa gtggatgagg tggttgttca ggacgaggta
     8821 atgtatggtt cgattttaga aagaataaaa ccggattatg ttatacatgg agataattgg
     8881 ctaaatgatc caatggaagt gatccgtgat aatgtcattg aaaatctgaa aaaatgggga
     8941 ggtcagttaa tagaaatccc atatacatat aatgagcagg taaggaatat tgaagctgtt
     9001 atgcgagaaa ggactgctat gccggaatat cgtagaaaac ggttacggca attattacag
     9061 ttatgtccaa tagtaaagac actggaagtg catagtggtc tgaccggatt gatagcggaa
     9121 aagacagttg tggccaataa cggtgagatt gatcaatttg atgcaatgtg gttatcaagt
     9181 ctgtgtgatt cgacagcgaa aggaaaacct gatattgaac tggtagacat gtcttccaga
     9241 cttcgtacgg tggatgacgt gttggaggtt acaacgaagc caatcatatt agatggggat
     9301 actggtggta tgattgagca ttttgtatac aacgtaagaa cattagaacg tgtaggggtc
     9361 tcagcagtta ttatcgagga taagacggga ctcaagaaaa actctttgtt tggaacagag
     9421 gtagagcaga cacaggatag tatagaaaac tttactgcaa aaatcagagc ggggaaacgt
     9481 gcgcagcgta caaaagattt tatgattatt gcacggattg agagccttat tttagaaaag
     9541 ggattagagg atgcacttgt gagagcattt gcatatgtgg acgcaggggc agacggcatt
     9601 atgattcaca gtagaaaaaa aactcctgat gaaatatttg cgttttgtga cagatttcgt
     9661 gaaaaagata aaattactcc tctggtcgtt gtgccgacct cttataatga gacatatgaa
     9721 agtgaactac aacagcatgg aattaatatt gtaatatatg cgaatcagct tacaagaagt
     9781 gcctttccag cgatgcagca gactgcaaca gatattttaa gatatcatag agcaaaggaa
     9841 gtggatgaca gactgatgtc aattaaagat attattacat tggttgatga agtttaaggt
     9901 aaatttcttg agagggttca tattcaaatc agattgaaga tgcatttcaa gctggaagag
     9961 gatatcaata ttcagttgat catcagtaga aaattgagga cttacaattg agataacaaa
    10021 tcatcatgag taaccgggag cggctcacag ccgctcacaa taccccccga acttctcctc
    10081 cgtcatcccc tcctcaatca tccgatacag ctccagctgc ttcggaatca gagcactgta
    10141 cacagactga gaataatccg gcacctctgt gaacaccgtt ttttctaatt ctttgtagaa
    10201 agaataggag ggtttaaaat cccggagttt tgcaaaatac agtgtctcat acagataggt
    10261 atggagaaaa tatagtttga tttcatcata gtattcctgg aaaaacggcg tattcttcat
    10321 aaaattccag acggcaagtt ggacatcggc atgcattttt agggtttctt cctgtctcat
    10381 atcatttcgc atggttccag aatcattttg tctgtaataa tagtaggcat cgtttaagat
    10441 tacgatttta tttgcaaaat ataaaagcgg atatacaaag agcggttctt cgtaaataac
    10501 atgctctgca taagcggtat gagcagtttt taaaagatcg tgacggtaaa gtttattcca
    10561 gcagccatag gtaattttct ctgagatcaa aaattctttt cggtcattga cagaagaaat
    10621 ttcaatcact tccggcataa tgttccgacc ggagtccacg gcacccagac ggtctgtata
    10681 ataaaaatat tcaaactgga tgatatcagc atccgattct ttggcttttt cataagtttc
    10741 caacagaaaa ttctcagcga caaagtcatc agcgtcaaca aatgcaatat attcacccgt
    10801 tgcatactgc agggcaacat ttcttgcacc gccctggcgc atattttcct caagttttaa
    10861 gatcataatg ctttccggat aggcgcgttc aaattcctgc agcatgttcc aggtagcatc
    10921 ctcatctgtg gatgcatcgt ctacaaagat cagttcgatc tggtcaattc cgattgtctg
    10981 ctgtacaagt gacataaagc atttcggaag atattttgtt gcattaaaac atgggatgat
    11041 gacacttact tttttcatag atcgaaattc tcctggtaaa aaggttacgt atggtataat
    11101 aaacaaaaat ggtatattat taatttatca caacaaaaag gaatgcacaa tatcagtctg
    11161 aaaagcaggg aggttacaat gtctggaaat atagcgatcg gtatacagga tttttccaca
    11221 atcatccagg gaaactattt ttatatagat aaaacgcctt ttattaaaga atggtgggat
    11281 tgcggggaca gtgcgacttt gatcacccgt ccgcgtcgtt ttggaaagac acttacaatg
    11341 agtatggtgg agcagttctt ttccatagac tatgccggca ggtcagattt gtttgaacat
    11401 ctggcgatct ggaaagaaga aaaataccgt gagctgcagg gaacttatcc tgtcatcagt
    11461 ctgtcatttg cgcggattaa agagagagat tatgagaaaa caaaacaaaa gatgtgtgag
    11521 gtgttaagaa acatatatat aaagttttgt tatattaaag acagtgaaaa gcttacagat
    11581 gccgacagag catattatga gcgtatgttg gaggaaaata taaaagagac ggatgcgaca
    11641 tcttctttat atcagttatc agatttcctg tatagatatt atggaaaaaa agttatcatt
    11701 ttgttagacg aatatgatac acccatgcag gaagcatttg tggatggtta ctgggatgaa
    11761 cttgtcgcat tcacccgaag cctgtttaat tcgacattta agacaaatcc ggcactggaa
    11821 cgtggaatta tgacgggaat cacaagagta agtaaggaat ccgttttttc agatttgaat
    11881 aacttaaaga tagttacgac tacatcaaat gaatatgctt ctgtatttgg ttttacagag
    11941 aaggaagtct ttgatgcatt ggaacagtat ggtcttgaga aagaaaaaaa agaggtaaaa
    12001 agatggtacg atggtttcat ttttggggaa cacaaagata tttataatcc atggtcaatt
    12061 ttaaattatc tcgatacaca gttatacaaa acattttggg caaatacaag tgcaaatagt
    12121 ctggtaggaa aattgattca ggaaggaaac cgtacaatta aggaaaaatt tgaaaaatta
    12181 ttgtgcggag aatacatctg gtcagaaatt gaagagcaga ttgtatacaa tcaattaaat
    12241 ggaaatgaaa aagcagtttg gagtcttttg ctggcgagtg gatatttgaa agtattatct
    12301 tatgaaacgt atcaggatat tgaggagggg aagatgccga aataccagct tgcgttgacg
    12361 aatctggaag taaagttaat gtttcagggt atggtacatg actggtttgc tcctgtacaa
    12421 ccagattaca atgattttgt aagggcaatg ttacttggtg atgtggatgc gatgaatgaa
    12481 tacatgaatc gaattgctat acagacattt agttatttcg acaccggaga gagggcatcc
    12541 ggggcagagc ctgagcgttt ttaccatggt tttatattag gtctgcttgt tgacctgcgg
    12601 gatagatatt accttaaatc caaccgtgaa agtgggtttg gcagatatga tgtaatgtta
    12661 gaaccgaaaa attcaaagga atgcaaagca gttattttag aattcaaagt tcgaaatcca
    12721 cgaaaggaaa aaagtattca agagacagtt ctgtctgcct taaagcagat ctgtgagaaa
    12781 aaatacgatg cagacctgct tgataaagga atcagaaagg aacagatata tcattatgga
    12841 tttgcatttg aaggcaaaaa agttttgatt gggacagaca gggaggagtg aatatgccca
    12901 ccaatatagc gatcggcaca caggagaaca accacatgtt atcagtctgc atcatcacca
    12961 aaaatgaaga acacaatctg gcacgctgcc tgaaatcatt ccagaacacc ggatttgaac
    13021 tggtcgtagt agataccgga tcgacagatc agacaaaaaa aatcgccgca gaatatacgg
    13081 aaaatatcta tgatttccca tggtgcgatg atttttcggc agcaaagaat tttgcggttt
    13141 caaaagcaac acatccgtat gtgatggtca ttgacagtga tgaatatcta cagaagattg
    13201 atctgtcacg gttagaaaag atgattgtcg aacatccggg cgaggttgga aggattcaaa
    13261 gaatcaatat catttccgga aaagacggca agcaggaaaa taaagagtgg atcaaccgta
    13321 tttttgcaaa agaaagtttt cattacacgg gaagaatcca tgagcaggta accgcctatg
    13381 atgaaaagga atatcgtaca tacgaagcac cagttttgat cggccatacg ggttatgatc
    13441 ttccgaagaa agaaaaaaag gcaaaagcac tgcgcaacat aagactgttg gagcaggaat
    13501 taaagaattc aggatgggat gcaaaagtgc atgccacgca gttagaacag aatctctcaa
    13561 agcaggatac ggatgcagag cagaaatctg aaattgcaga tgcaaaaaaa gagcagcaga
    13621 tcccgtatct attataccag cttggaaaaa gctattacat ggcagaagat tatgacgagg
    13681 catgcttctg gtttgcccat ggtctaagct atgaccttga accaaagtta gagtatgtga
    13741 tcgatatggt ggaaacctac ggctatgccc tgatcaacag cggacgcgcc ggggaagcac
    13801 ttttctttga aaacatttac gaagaatttg gaaatagcgc ggactttcaa tttctgatgg
    13861 ggctcatcta tatgaacaac gctatgtttg atgcagcagt tggagagttc cttaaggcgg
    13921 taaggcaccg ggactgcagg atggcgggag taaattccta tgcagcttat tataatgttg
    13981 gagttattta tgaatgcctg gggaaaatca gtgatgcaaa gtattattat cagaagtgcg
    14041 gtggttatga gccggcaaaa aaacgtttaa gattgataaa cagttaaatt tattatagtc
    14101 agcttattgg agaaacagag tgaaaaatat aatttttcaa atgcagaatg gagattagaa
    14161 tgggaatata tttaaatccg ggaaatgaag aatttcagaa agcacttaat tccaagatat
    14221 atgtggataa aaccatgctg atttctgaaa tgaatcagaa tctgaatacc gaacatcaga
    14281 atatatgcgt aagcagacct cgccgttttg gaaaatctat gactgcaaat atgcttgtag
    14341 cttattatag caagggatgt gattcgaaaa gcatgtttgc ggattataag attgcacagg
    14401 atgaaagttt tgaggcaaat ctgaataaat ataatgtcct tcatgtcaac atgcttgact
    14461 ttcttaaccg ggcgcagtcg gtggatgcaa tgatcgatta tatgcaaaag agacttttat
    14521 gggatatcag gcgggaatac ggagatgtag actgttttga ccgggaagat cttattgatg
    14581 tattagagaa catctatagt cagaaaaaac agaaatttat catcattatc gacgagtggg
    14641 attgcatatt tcgaaagtat ccgggggatg atgaagcaca gaaaaaatat ctggatttct
    14701 tgtgcctgtg gatgaaagat aagccatata ttgcgttggc ttatatgacg ggaatactgc
    14761 cgattaaaaa gtatggcgag cattcagctc tcaatatgtt tgatgaatat tccatgacca
    14821 atcaaaggga actcgctgaa tttaccgggt ttacggaaga ggaagttcaa agtctgtgtg
    14881 tgtcatatgg tatgcct
//
