LOCUS       c00036_gnlPro..        12757 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GFOGEDAG_36.
ACCESSION   c00036_gnlPro..
VERSION     c00036_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 07:38:46
            Original ID  :: gnl|Prokka|GFOGEDAG_36
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12757
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12757
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[162:10363]"
                     /cutoff="10000"
                     /detection_rule="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /neighbourhood="10000"
                     /product="NADH_dehydrogenase_I"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      163..10363
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /neighbourhood="10000"
                     /product="NADH_dehydrogenase_I"
                     /protocluster_number="1"
     cand_cluster    1..12757
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /kind="single"
                     /product="NADH_dehydrogenase_I"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12757
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NADH_dehydrogenase_I"
                     /region_number="1"
                     /rules="(Oxidored_q4 and Oxidored_q6 and Complex1_30kDa and
                     Complex1_49kDa and NADHdh and Oxidored_q3 and Oxidored_q2
                     and minimum(4, [Fe-2S_thioredx, Fer2_4, Fer4_7,
                     Molybdop_Fe4S4, Molydop_binding, NADH-G_4Fe-4S_3,
                     NADH_4Fe-4S, Proton_antipo_M, Proton_antipo_N, SLBB]))"
                     /tool="gutsmash"
     CDS             complement(163..1602)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_1"
                     /sec_met_domain="Proton_antipo_M (E-value: 2.3e-73,
                     bitscore: 236.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYSQFLNMREELSLIAVLLLLFLADLFMSPDAHKNSGKARLNTM
                     LPVILMAIHTAINLIPGTATDAFGGMYHYVPMHTVVKSILNVGTLIVFLMAHEWMKRED
                     TSFKQGEFYVLTLSTLFGMYLMISAGHFLMFFIGLETASIPMAALIAFDKYRHNSAEAG
                     AKYILTALFSSALLLFGLSMIYGSAGTLYFDDLPAHIDGNPLQIMAFIFFFTGMAFKLS
                     LVPFHLWTADVYEGAPSTVTAYLSVISKGSAAFVLLAVLIKVFAPMINDWQEVLYWVTI
                     ASITIANIFAVRQQNLKRLMAFSSISQAGYIMLGVIGGTAQGMTALVYYVLVYAAANLG
                     VFAVITIVALRSQKFTLEDYAGLYKTNPKIALLMTLSLFSLAGIPPFAGFFSKFFIFMA
                     AFDVGFHLLVFIALVNTVISLYYYLLIVKAMYITPSDNPIPTFRSDRCTKWGLALCTLG
                     IIGLGIASIVYQSIDKLSFGI"
     CDS             complement(1640..3124)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_2"
                     /sec_met_domain="Proton_antipo_M (E-value: 1.9e-68,
                     bitscore: 220.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFLSIFVLIPLLMLAGLWAARGIKAIRGVMVTGASALLIASVVL
                     TFLYLGERSAGNTAEMLFRADTLWYAPLHISYSVGVDGISVAMLLLSAVIVFTGTFASW
                     RLQPLTKEYFLWFTLLSMGVFGFFISVDLFTMFMFYEIALIPMYLLIGVWGSGRKEYAA
                     MKLTLMLMGGSAFLLIGILGIYFGSGATTMNLLEIAQLHNIPFAQQCIWFPLTFLGFGV
                     LGALFPFHTWSPDGHASAPTAVSMLHAGVLMKLGGYGCFRIAMYLMPEAANELSWIFLI
                     LTGISVVYGAFSACVQTDLKYINAYSSVSHCGLVLFAILMLNQTAATGAILQMLSHGLM
                     TALFFALIGMIYGRTHTRDVRELAGLMKIMPFLSVCYVIAGLANLGLPGLSGFIAEMTI
                     FVGSFQNNDVFHRTLTIIACSSIVITAVYILRLVGKILYGTCTNKHHLELTDATWDERV
                     AVICLIVCVAGLGMAPFWVSHMIGESVLPVVSQLIP"
     CDS             complement(3163..5094)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_3"
                     /sec_met_domain="Proton_antipo_N (E-value: 1.9e-25,
                     bitscore: 78.5, seeds: 433, tool: rule-based-clusters)"
                     /sec_met_domain="Proton_antipo_M (E-value: 1.7e-87,
                     bitscore: 283.0, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTILILLLPFFSFLILGIGGKWMSHRTAGTIGTLILGAVAVLS
                     YVTAIQYFSAPRLEDGTFATLMPYNFTWLPFTETLHFDLGILLDPISVMMLIVISTVSL
                     MVHIYSFGYMKGEVGFQRYYAFLSLFTMSMLGLVVATNIFQMYLFWELVGVSSYLLIGF
                     YYTKPAAIAASKKAFIVTRFADLGFLIGILIYGYYGGTFGFTPDTVSLISGGASMLPLA
                     LGLMFVGGAGKSAMFPLHIWLPDAMEGPTPVSALIHAATMVVAGVYLVARMFPLFITYA
                     PNTLHMVAWVGAFTAFYAASVACVQSDIKRVLAFSTISQIGFMMVALGVCTSMNPHEGG
                     LGYMASMFHLFTHAMFKALLFLGAGSIIHAVHSNEMSAMGGLRKYMPITHWTFLIACLA
                     IAGIPPFSGFFSKDEILAACFQYSPVMGWVMTVIAAMTAFYMFRLYYGIFWGSEPPRAG
                     SHSEHNTPHGNLEAAPCRPHESPLAMTFPLMFLAVVTCGAGFIPFGHFISSNGESYSIH
                     LDPSVAITSVVIAIISIAIATWMYKNAKQPVADSLAKRFKGLHKAAYNRFYIDDIYQFI
                     THKIIFRCISTPIAWFDRHVVDGFFDFLAWATNTTSDEIRGLQSGQVQQYAYVFLCGAL
                     ALILLLIL"
     CDS             complement(5286..5594)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_4"
                     /sec_met_domain="Oxidored_q2 (E-value: 2.7e-22, bitscore:
                     68.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHMEYYLVVSTIMMFAGIYGFFTRRNTLAILISVELMLNATDIN
                     FAVFNRFLFPGGMEGYFFALFSIAISAAETAIAIAIMINIYRNLRSIQVRNLDELKW"
     CDS             complement(5632..6144)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_5"
                     /sec_met_domain="Oxidored_q3 (E-value: 4.2e-38, bitscore:
                     120.0, seeds: 708, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSTLETVVFYFLAAFIIAMSIMTVTTQRIVRSATYLLFVLFGTA
                     GIYFLLGYTFLGSVQIMVYAGGIVVLYVFSILLTSGEGDRAEKAKRSKVLAGLFTMIAG
                     LAIILFITLKHDFMQTANLAPQEISIHAIGNALLSSDKYGYVLPFEAVSILLLACIIGG
                     IMIARKR"
     CDS             complement(6147..6635)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_6"
                     /sec_met_domain="Fer4_7 (E-value: 3.1e-13, bitscore: 39.9,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 9e-06, bitscore: 15.9,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYKDKKYTYLGGLVHGISTLATGMKTSIKVYFRKKVTEQYPENR
                     KELKMFDRFRGTLNMPHNENNEHRCVACGLCQMACPNDTIKVTSETVETEDGKKKKILA
                     TYEYDLGACMFCQLCVNACPHDAITFDQNFEHAVFDRTKLVLKLNHDGSKVIEKKKEV"
     CDS             complement(6648..7724)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: NADHdh"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_7"
                     /sec_met_domain="NADHdh (E-value: 3.4e-123, bitscore:
                     400.3, seeds: 435, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDFSIVTNWIHELLLSIMPEGLAIFIECVAVGVCLVALYAILAI
                     ILIYMERKVCGFFQCRLGPNRVGKWGSIQVVCDVLKMLTKEIFMPKGADHFLYNLAPFM
                     VIIASFLTFACIPFNKGAAILDFNVGVFFLLAASSIGVVGILLAGWGSNNKFSLIGAMR
                     SGAQIISYELSVGMSIMTMVVLTGTMQFSEIVEGQADGWFIFKGHIPAVIAFIIYLIAG
                     NAECNRGPFDLPEAESELTAGYHTEYSGMGFGFFYLAEYLNLFIVASVAATIFLGGWMP
                     LHIVGLDGFNTVMDYIPGFIWFFAKAFFVVFLLMWIKWTFPRLRIDQILNLEWKYLVPI
                     SMVNLLLMACCVAFGFHF"
     CDS             complement(7745..9337)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Complex1_30kDa"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Complex1_49kDa"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_8"
                     /sec_met_domain="Complex1_30kDa (E-value: 1e-36, bitscore:
                     115.9, seeds: 586, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_49kDa (E-value: 8e-66, bitscore:
                     211.5, seeds: 265, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEIQFIAPAALHDEMLRLRNEKQMDFLESLTGMDWGVADEKDAP
                     EKLRGLGVVYHLESTITGERIALKTATTNRELPEIPSVSDIWKIADFYEREVFDFYGIT
                     FVGHPDMRRLYLRNDWIGYPMRKDNDPEKDNPLCMTNEKTFDTTQEIELNPDGTIKNKE
                     TKLFGEEEYVVNIGPQHPATHGVMRFRVSLEGEIIRKIDANCGYIHRGIEKMNESLTYP
                     QTLALTDRLDYLGAHQNRHALCMCIEKAMGIEVSERVQYIRTIMDELQRIDSHLLFYSC
                     LAMDLGALTAFFYGFRDREKILDIFEETCGGRLIMNYNTIGGVQADLHPNFVKRVKEFI
                     PYMRGIIHEYHDIFTGNIIAQSRMKGVGVLSREDAISFGCTGGTGRASGWACDVRKRMP
                     YGVYDKVDFKEIVYTEGDCFARYLVRMDEIMESLNIIEQLIDNIPEGPYQEKMKPIIRV
                     PEGSYYAAVEGSRGEFGVFLESQGDKTPYRLHYRATGLPLVAAIDTICRGTKIADLIAI
                     GGTIDYVVPDIDR"
     CDS             complement(9420..10022)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q6"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_9"
                     /sec_met_domain="Oxidored_q6 (E-value: 1e-26, bitscore:
                     83.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEITKKPKIKSIPYDEFIDNESLEKLVKELNAGGANVALGVLDDF
                     INWGRSNSLWPLTFATSCCGIEFMALGAARYDMARFGFEVARASPRQADMIMVCGTITN
                     KMAPVLKRLYDQMPDPKYVVAVGGCAVSGGPFKKSYHVVNGVDKILPVDVYIPGCPPRP
                     EAFYYGMMQLQRKVKIEKFFGGVNRKEKKPDYLRNEE"
     CDS             complement(10013..10363)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_10"
                     /sec_met_domain="Oxidored_q4 (E-value: 2.5e-38, bitscore:
                     120.0, seeds: 391, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFTFLVVVLLTALAFVGVVIALSRAISPRSYNLQKFEAYECGIP
                     TRGKSWMQFRVGYYLFAILFLMFDVETAFLFPWAVVMRDMGPQGLISVLFFFIILVLGL
                     AYAWRKGALEWK"
     CDS             complement(10482..10859)
                     /locus_tag="ctg36_11"
                     /transl_table=11
                     /translation="MKQSLKFGLLLVLALLIHCATNGAMEDMCKVSSPTYRQEKCYVSQ
                     DRPIQDALERLYNLYTTQTCDMSHTDVAHVPTDKSMFLLIAYFCDHYKHQSPPYPVSSH
                     SPTYYYDPISYYIYGLRKIVI"
     CDS             11120..12724
                     /locus_tag="ctg36_12"
                     /transl_table=11
                     /translation="MKRTLWFIFFLLNSLFYLYADSENDSLLKVLDKVISERLIYTQKK
                     EATIKELKKKKVGLNSLEDIYNLNKEIIHQYETFVCDSAEQYIHENIDIAKTIGNKEYL
                     LEERLRLAFVYSLSGLFIQANDIFKSIKCADLPDHLKALYCWNRIRYYENLIKYTDDVR
                     FSNEYISEKEAYRDTVMSILFDQSDEYRKEKAVKLQDKGSTKEALLILTEIYDKQEPAS
                     HGYAMMAMGLARAYRLIGNYALEEKFLMLAAMTDTKLAVKENEALLTLAVNLYHKGDID
                     RAYNYIKVALDDAIFYNSRFKNTVIARIHPIIENTYLIRLEKQKQNLRFYIFLTSLFVV
                     ALAITLYFTYKQTKIVSRAKRHLKAMNEELVGLNKNLDEANLIKEKYVGYFMNQCAVYI
                     NKLDEYRKNVNRKIKTGQIDDLYKSSSRPFEKELEELYHNFDKAFLNLYPNFVEKFNSL
                     LKPEERYKLEKDQLNTELRIFALIRLGITDVGQIAVFLHYSVQTIYNYKSKVKRMSTLD
                     SNIFEEEVKKLGSLSQK"
ORIGIN
        1 cttgcagata tatcaaagca atttatatat taatatgttg attattaggc gtaaaagcac
       61 attctaaggg gcgactatat agaagaaacg gtcttggttt tgatgtcgat tgatactgac
      121 atgaaaccaa gaccgtttct ttggtgaaaa ggtgtagtcc gtttaaattc cgaacgacag
      181 tttatcgata gattgatata cgatacttgc aatacccagt ccgatgatac ccaatgtgca
      241 aagtgctagt ccccattttg tgcaacgatc gctgcggaaa gtaggaatcg ggttgtcgga
      301 aggagtgatg tacattgctt ttacaatcaa tagatagtaa tacaacgaaa tcactgtatt
      361 taccaatgcg atgaatacca gcaagtggaa acctacatcg aaagcagcca tgaagataaa
      421 aaacttagag aagaatccgg caaacggagg gatgcctgcc aatgagaaca gagacagagt
      481 catcaagaga gcgattttag gattcgtttt ataaagtcct gcgtaatctt cgagcgtgaa
      541 tttctgactg cgtaatgcca cgatagtgat aacggcaaat actccgaggt tggcggcagc
      601 gtacactaat acataatata ccaatgccgt catgccttgt gctgtgcctc cgataacgcc
      661 taacataata tatcccgctt gcgaaatact ggagaacgcc atcaaacgtt tcaggttttg
      721 ctgacggaca gcaaatatat ttgcaatagt gatagaagcg atggttaccc aataaagtac
      781 ttcctgccag tcattaatca ttggagcgaa tactttgata aggacagcca ataaaacaaa
      841 tgctgccgat ccttttgata taacactcaa ataagcggta actgtactcg gagcgccttc
      901 gtaaacgtct gctgtccata agtggaacgg aaccagtgac aacttgaatg ccattcctgt
      961 gaagaagaat ataaatgcca tgatctgtaa cggatttccg tcgatatggg cagggaggtc
     1021 atcgaaataa agagtcccgg cagaaccata gatcatggac agaccaaaca acagcaatgc
     1081 actggagaaa agagctgtca gaatgtattt ggcacctgct tcggcagagt tgtgacggta
     1141 tttatcgaag gcaatcaatg ctgccatcgg aatagaagct gtttcaagac cgatgaagaa
     1201 catcaggaaa tgtccggcgg aaatcatgag atacatacca aacaaggtag agagtgtaag
     1261 cacatagaat tctccttgtt tgaatgaagt gtcttctctt ttcatccact cgtgcgccat
     1321 caggaaaaca atcagtgtac cgacattcag gatcgattta acaactgtgt gcatcggtac
     1381 atagtgatac ataccaccga atgcatcggt agcagttccc ggaatcaagt tgatagccgt
     1441 atggatagcc atcagaataa cgggcaacat agtgttcagg cgtgctttcc cactattttt
     1501 gtgtgcatcc ggactcatga agaggtcagc tagaaatagc agcagtaaga cagctatgag
     1561 cgacagctct tctcgcatat ttagaaattg tgaataatcc atcttgttta tttatgaatt
     1621 aagaattatg atttatgagt taggggatta gttgtgagac aaccggtaat acgctttcac
     1681 caatcatgtg gctaacccag aaaggagcca tacctagtcc ggcaacgcaa acgatgaggc
     1741 agataacggc tacacgttcg tcccaagttg cgtcggtcag ttcgaggtga tgtttgttgg
     1801 tgcaggttcc gtatagaatc ttacctacca ggcgcaggat gtagactgcg gtaatcacaa
     1861 tcgaagagca ggcgatgatg gtcagtgtgc ggtgaaatac gtcgttgttc tggaaagagc
     1921 cgacgaagat ggtcatttca gcaatgaaac cgcttaatcc cggcagaccg aggttggcaa
     1981 gaccggcaat cacataacat acactaagga acggcataat tttcattaaa ccggcaagtt
     2041 cgcgaacgtc acgtgtgtgt gtacgtccat atatcatacc gatcagagca aagaacaagg
     2101 ctgtcattaa tccgtgtgaa agcatttgaa ggattgctcc tgttgctgct gtctggttta
     2161 gcatcagaat ggcgaaaaga accagtccgc agtgagatac ggatgaataa gcattgatat
     2221 atttcaagtc ggtctgtacg caagcggaga aggctccgta gactacagag atacctgtca
     2281 gtatcaggaa tatccaggaa agttcgttgg ctgcttccgg catcagatac atggcgatac
     2341 ggaaacatcc gtaacctccc agtttcatca atactccggc atgaagcatg gatacggcag
     2401 tcggggcaga agcgtgaccg tcaggactcc atgtgtggaa cgggaaaagg gcgcccaata
     2461 caccgaagcc gaggaaagtc agcgggaacc agatgcattg ctgtgcaaaa ggtatgttgt
     2521 gcaactgtgc aatttcgaga aggttcatgg tggttgctcc cgagccgaaa tagattccga
     2581 gaataccgat caataggaaa gcggaaccgc ccatcaacat aagggtcagt ttcatggctg
     2641 catattcttt acgtcctgat ccccatacac caatcagcag gtacatcggt atcaacgcaa
     2701 tttcatagaa catgaacatg gtgaacaaat cgacggatat aaagaatccg aatactccca
     2761 tagacaacag ggtgaaccag aggaaatatt ctttcgtcag cggttgcagg cgccaggaag
     2821 cgaatgtacc ggtgaatacg atgacagcag acaataacaa catggctacc gaaattccgt
     2881 caacacctac tgaataagat atgtgaagcg gggcatacca aagcgtatct gcacggaaaa
     2941 gcatttctgc cgtatttccg gcgctacgct ctcccagata caggaatgta agtacgacgg
     3001 aggcaatcag aagtgccgat gcgccagtaa ccataacccc ccggatggct ttgattcctc
     3061 gtgctgccca aagtccggcc agcatcaata aggggataag tacgaatatg gataagaaat
     3121 tcatctttat gatttactat ttaaagattt actatttact atttagagaa tcagcagtag
     3181 gataagtgcc aatgcaccgc aaaggaacac atacgcatat tgttgtacct gaccgctctg
     3241 caaaccacga atctcgtcgc ttgttgtatt ggtggcccat gccaggaagt caaagaatcc
     3301 atccactaca tgacggtcga accatgcgat aggagtagag atgcagcgga agataatctt
     3361 atgcgtaata aactggtaga tatcatcaat atagaagcga ttataggctg ccttgtgcag
     3421 acctttgaat cgttttgcca acgaatcagc aacaggctgt ttggcattct tgtacatcca
     3481 tgtagcgatt gcaatcgaaa taatcgcaat aacaacgctc gtaatagcta ctgacggatc
     3541 gagatggata gaataagatt caccattcga actgatgaag tgtccgaaag gaataaatcc
     3601 tgctccacaa gttacaactg ccaggaacat cagcgggaaa gtcatagcca acggactctc
     3661 atgtgggcgg caaggtgccg cttccaagtt tccgtgcggc gtgttatgtt ccgaatggga
     3721 acctgcccgg ggcggctcgc tcccccaaaa aataccgtag taaaggcgga acatatagaa
     3781 agctgtcatt gcagcgatga ctgtcatcac ccatcccatt acagggctgt attggaaaca
     3841 agcagccaga atttcatcct tcgagaagaa gcccgagaac ggaggaatac cggcaatagc
     3901 cagacaagca atcaggaatg tccagtgagt gatcggcata tatttgcgta aacctcccat
     3961 agcggacatt tcattagaat gtacggcatg gataatgcta cctgcaccga ggaagagtaa
     4021 tgccttaaac atggcatgtg tgaaaaggtg gaacatggaa gccatgtagc ccaaacctcc
     4081 ttcgtgcgga ttcatggaag tacaaacacc cagagctacc atcatgaagc caatctgtga
     4141 aatggtagag aaagccagta cacgtttgat gtctgattgt acgcaagcca cacttgccgc
     4201 gtagaatgct gtaaatgcac ctacccaagc aaccatgtgc agcgtattcg gtgcgtatgt
     4261 aatgaaaagt gggaacatac gtgccaccag atatacaccg gcaactacca tggtagccgc
     4321 atgaatcaat gcgctgaccg gagtaggacc ttccattgca tccggcaacc agatatgcaa
     4381 cgggaacatg gcacttttac cggcaccacc gacaaacatc agtccgagag ccaacggaag
     4441 catagaagct ccaccgctta tcaaggatac tgtatccgga gtgaagccga atgtaccacc
     4501 gtaatatccg taaatcagga taccgatcag gaagcccaag tcagcaaagc gagtaacaat
     4561 aaacgctttc ttggaagcag caatggcagc cggttttgta taataaaaac cgattagcag
     4621 gtaagaactt acccccacca gctcccaaaa aaggtacatc tggaagatgt tggttgcaac
     4681 gaccaatccc agcatagaca tggtaaacag ggataggaaa gcgtaatagc gttgaaaacc
     4741 gacttctcct ttcatgtaac cgaaagagta gatatgtacc atcagtgaca ctgtagagat
     4801 gacgatcaac atcattaccg atataggatc gagcaagatg cccaaatcga agtgtaaagt
     4861 ctctgtaaaa ggaagccacg tgaagttgta aggcatcagt gtggcgaatg ttccgtcttc
     4921 cagtcgtgga gcggagaaat attggatagc tgtaacgtag gatagtactg ctactgctcc
     4981 cagtatcagc gtaccgattg tacccgctgt ccggtgggac atccatttac ctccgattcc
     5041 caatatgaga aaggagaaga aaggaagaag gagtattaga attgttagtt ccatacagtt
     5101 ttatttaatt acttgagtta ttattattaa tttttggtct tatagctgat aatcactata
     5161 ctcggacctt ctgtttggtt tcccggtgtg aaactagttg ttcctcggtg agaaacactt
     5221 tgtttctcgg tgtgaaacga agtgtttcaa gggatgaaac accttgttcc tgggaatgaa
     5281 acaaatcacc acttcaactc gtccaggttg cgcacctgaa tgcttcgaag attacgataa
     5341 atgttaatca tgatggcgat agctattgca gtttccgcag ccgagatggc gatggaaaag
     5401 agtgcaaaga aataaccctc cattcccccc ggaaaaagga aacgattgaa tacggcgaag
     5461 ttgatgtccg tagcattcag cattaactct acagaaatca ggatagccag tgtatttcgg
     5521 cgggtaaaga atccatagat tcctgcaaac atcatgatgg tagaaactac caggtaatat
     5581 tccatgtgta tcatattcga actctatttt gatagttaat acttaaaatt cctatctctt
     5641 acgtgcaatc atgatgccac cgatgataca cgccagcaat aatatgctga cagcttcgaa
     5701 aggcaataca taaccgtatt tgtcactact taataaagcg ttcccgatag catgaatgct
     5761 aatttcttgc ggggccaaat tagctgtctg catgaaatcg tgcttcagtg tgataaacag
     5821 gataatggcc aaaccggcaa tcatagtgaa gagtccggct aagactttac ttcgttttgc
     5881 tttctcggcc cggtcgcctt ctccactggt caataggatg gagaatacat aaagaacgac
     5941 gataccaccg gcataaacca taatctgaac ggaacccaga aaggtgtaac ccagcaaaaa
     6001 atagatgccg gccgtgccga agagcacgaa gagcaggtag gtggccgagc gtacgatacg
     6061 ttgggtagtc accgtcatga tggacatagc aataataaat gctgccaaaa agtagaatac
     6121 tactgtttca agtgttgatc ccatatctaa acttcttttt tcttttctat tactttacta
     6181 ccgtcgtggt tcaacttcag gacaagtttc gtccggtcga agactgcatg ttcgaagttc
     6241 tggtcgaacg tgatggcatc gtgcggacaa gcattgacac agagctggca gaacatacag
     6301 gcacccaaat catattcata ggttgccaga attttcttct tctttccatc ttctgtttcg
     6361 acggtttcgc tggtcacttt gattgtatcg ttcggacagg ccatttgaca caatccgcaa
     6421 gctacacagc gatgttcatt attctcattg tggggcatat tcagcgtacc acgaaaacgg
     6481 tcgaacattt tcagctcttt ccggttttcg ggatattgct cggtcacttt cttacggaag
     6541 tataccttga tgctggtttt catacccgtt gccagtgtac tgatgccatg caccagacca
     6601 cctaagtacg tatatttttt atctttatat tccataattt tcatttatca aaagtggaag
     6661 ccgaaagcta cgcagcatgc cattaataat agatttacca tagaaattgg aaccaggtat
     6721 ttccattcca gattcaagat ctggtcgata cgcaagcgtg ggaaagtcca tttgatccac
     6781 atcagaagga ataccacaaa gaatgctttg gcgaagaacc agataaagcc cggaatataa
     6841 tccattacag tgttaaatcc atccaaacca acaatgtgca gcggcatcca tcctcccagg
     6901 aagatggtgg cggcaacact ggctacgata aacagattca agtattctgc cagatagaag
     6961 aaaccgaaac ccataccgga gtattcagta tgatatccgg ctgtcagctc actttccgct
     7021 tcgggaaggt cgaacgggcc acggttacat tctgcatttc cggcaatcag atagatgatg
     7081 aaagcaatga ccgcaggaat atgtcccttg aagatgaacc aaccatcagc ttgtccttct
     7141 acgatttcag aaaattgcat ggttcccgtc agcactacca ttgtcatgat actcatacca
     7201 accgaaagtt cataactgat aatctgtgca ccgcttcgca tggcaccgat caaagagaat
     7261 ttgttgttac taccccaacc ggccagcaag ataccgacaa ctccaatgct ggaagctgcc
     7321 aacaggaaga acacgcccac attaaagtcc agaatcgccg cacctttatt aaaaggaata
     7381 caagcgaaag tcaggaatga agcgataatc accatgaatg gagcaagatt gtaaaggaaa
     7441 tggtcggcac ccttcggcat gaagatttct ttggtcagca ttttgagcac gtcgcagacc
     7501 acttggatag aaccccattt accaacacgg ttcggtccaa gacgacactg gaagaaaccg
     7561 cagaccttac gctccatgta gatcaatatg atagccagga tggcatacag tgctacgagg
     7621 cacacgccga cagctacaca ttctataaag atggctaatc cctccggcat aatggagagc
     7681 agtagctcat gtatccagtt tgttactata ctaaagtcga acatatattt ttaataatta
     7741 agtattatct gtcaatatcc ggaacgacat aatctattgt tccgccaata gcaattaagt
     7801 ctgcaatctt tgttccccgg caaatggtgt caattgcagc aacaagcggc aatcccgtag
     7861 cacggtagtg caggcggtaa ggcgttttgt caccctgact ttccaggaag acaccaaatt
     7921 caccacgact tccttctact gctgcatagt aactgccttc cggaacacgg atgataggtt
     7981 tcatcttctc ctgataaggt ccctcgggaa tattgtctat taattgctca atgatgttca
     8041 gactttccat gatctcatcc atacgcacca ggtaacgggc aaagcagtca ccttccgtat
     8101 aaacgatttc tttgaaatcg actttgtcat atacaccgta tggcattcgt ttacgtacgt
     8161 cacacgccca tcctgatgca cggcctgtac ctccggtaca accgaaagag atggcatctt
     8221 cacggcttaa cacaccgacg cctttcatac ggctctgtgc gatgatgtta cccgtgaata
     8281 tatcgtgata ttcgtggata attcctctca tatatggaat gaactctttt actcgtttga
     8341 cgaagttagg atgaagatca gcctgtacac cgccaatcgt attgtagttc ataatcagac
     8401 gtccgccgca agtttcttca aagatatcga gaattttctc gcggtcacgg aatccataaa
     8461 agaatgctgt caacgctcct aagtccatag caagacaaga gtagaacagc aagtgagaat
     8521 cgatacgttg caactcgtcc attatggtac ggatgtactg tacgcgttca ctgacctcaa
     8581 tgcccatggc tttttcaatg cacatacaca atgcatggcg gttctgatgc gcgcccaaat
     8641 agtccagacg gtctgtcaaa gccaatgttt gagggtaagt gaggctttca ttcattttct
     8701 cgatgcctcg gtggatatac ccgcagttcg catcaatctt acgaataatt tcaccttcca
     8761 gagaaacacg gaagcgcatt acaccatggg tagcagggtg ttgcggaccg atgttgacta
     8821 catattcttc ttcgccgaac agtttcgtct ctttgttctt gatggttccg tccgggttca
     8881 gttctatttc ttgagtcgta tcaaacgtct tttcattggt catgcacagt gggttatcct
     8941 tttccggatc gttatcttta cgcatcggat aaccgatcca atcgttgcgc aggtagagcc
     9001 ggcgcatatc aggatgaccg acaaaggtga tgccataaaa atcaaaaact tcacgttcgt
     9061 agaagtcggc tatcttccag atgtcgctga cagacggaat ttccggtagc tcgcggttgg
     9121 ttgtcgctgt ttttagtgct atccgttcgc ctgtaatggt agattccaga tggtagacta
     9181 cgcctaagcc gcggagtttt tccggagcgt ctttctcatc ggctactccc cagtccatac
     9241 cggtgaggct ttcgagaaag tccatctgtt tttcatttcg caagcgcagc atctcgtcgt
     9301 gtaacgctgc aggagctata aattgtattt cttgcataaa tcaaattaaa ttaagaatga
     9361 aaaattaaga atgaaaaatc tgccgggatg ttgcatgcga attcttcatt catcattcat
     9421 cattcttcat ttcttaaata atccggtttc ttctcttttc tgtttactcc accaaagaac
     9481 ttttctattt tcactttgcg ttgcaattgc atcatgccat aatagaatgc ttcaggacgt
     9541 ggcgggcatc cgggaatata tacatctacc ggaagaatct tgtccacccc gtttactacg
     9601 tgataggact tcttgaaagg acctccgctg acagcgcatc cgcctacggc aaccacatac
     9661 ttcggatcgg gcatctggtc gtaaagtcgt ttcagtaccg gagccatttt attggtgatt
     9721 gttccgcata ccataatcat atcagcctga cgcgggctgg cacgtgctac ctcaaaccca
     9781 aagcgggcca tgtcataacg cgcggcaccc agtgccataa attcgatacc acaacaactg
     9841 gttgcaaagg taagcggcca cagtgaattg ctgcgtcccc agttgataaa gtcgtcaagt
     9901 actccgaggg caacattggc tcctcctgca ttaagttctt tgaccaactt ttccaatgat
     9961 tcattgtcga taaactcatc atacggaata gattttattt ttggcttttt ggttatttcc
    10021 attccaaagc tcctttcctc caggcataag caagacccag aactaaaatg ataaagaaga
    10081 agagaacact aataagtccc tgtggtccca tgtcacgcat aactaccgcc cacggaaaca
    10141 gaaaagctgt ttcgacatcg aacataagga ataggatggc aaacaagtag tagcctacac
    10201 ggaactgcat ccatgattta ccacgtgtcg gtataccaca ttcataagcc tcaaactttt
    10261 gcaggttgta tgaacgggga gagatagcac gcgagagggc tattactaca ccgacaaaag
    10321 caagcgctgt cagtaaaaca acaactaaaa atgtaaaatt cataattcaa tagctgttta
    10381 gattgaatat tatatagaaa taagcaatta gtctattcgc cctatggaga ataaaaccaa
    10441 ctgtaataaa tgacgagcaa aagagtctac tgtactgtag gctaaatgac aatctttctc
    10501 aacccatata tataatagga gataggatcg taataatatg taggagaatg ggatgagaca
    10561 gggtaaggtg gactttgatg tttgtaatgg tcacagaaat aagcgattaa caaaaacatg
    10621 cttttatctg tcggaacatg tgcgacgtct gtatgactca tgtcacaggt ttgcgtcgta
    10681 taaagattat aaagacgttc caaagcatcc tgaatcggac gatcttgtga tacatagcat
    10741 ttctcctgcc gataagtcgg ggaggaaact ttgcacatat cttccattgc tccgttagtt
    10801 gcacaatgga tgagcaaagc caacactaaa agtagtccga attttaagct ttgtttcatc
    10861 tttctctttt aacggctgca aatatagaac taatatttat actttttgca aagtccgtat
    10921 ggcaaaaaag ctttttttaa ctccatatct tttagattca ttttttagtc agcatggttt
    10981 cacaaatatc atttagaatg gggtaatttc tccatcttca tttgttaaaa gatgcaataa
    11041 aaagaatgat ttacgctctt tttggcgaat aacacaaaga aaatacattt ttttgcagat
    11101 taagaaagaa tacatgatta tgaaacgcac actttggttt atatttttcc ttctaaactc
    11161 cttgttttac ctctatgcag atagtgagaa tgattctttg ttgaaggtgt tagacaaagt
    11221 gatttctgaa cgtttgatat atacccagaa aaaagaagct accataaaag aattaaagaa
    11281 aaagaaagtt ggccttaatt cgttggagga tatatacaat ttaaataaag agattatcca
    11341 tcaatatgag acttttgtct gtgactcggc agaacaatat attcatgaga atattgatat
    11401 agcaaaaacg atcggtaata aagaatatct tttggaagag cggctccggt tggcttttgt
    11461 ctattcttta tccggtttgt ttattcaagc aaatgatatt tttaagtcga taaaatgtgc
    11521 ggatttacct gatcatttaa aagctttgta ttgctggaat cgtatacgtt attatgaaaa
    11581 tctcattaaa tacacggacg atgtacggtt ttcaaacgag tatatatcgg aaaaagaggc
    11641 ttatcgggat actgtgatga gcatcttatt tgaccagtcg gatgaatata gaaaagaaaa
    11701 agctgtgaag cttcaagata agggaagtac caaagaggct cttctgattt tgacagagat
    11761 atatgataaa caagagccgg catctcatgg atatgctatg atggctatgg ggcttgccag
    11821 ggcttatcgg ttgattggga attatgcact ggaagaaaag tttctaatgc tggctgctat
    11881 gacagataca aaactggctg tcaaagagaa tgaggcatta ttgacattgg cagttaattt
    11941 atatcataaa ggagatatag atagggctta taactatatt aaagtagcgt tggatgatgc
    12001 catcttttat aattctcgtt ttaagaatac agtaattgcc cgcatccatc cgattattga
    12061 aaatacatac ttgatccggt tggaaaaaca aaagcagaac ctccgtttct atatatttct
    12121 gactagcttg tttgtggtag ctcttgctat caccctgtat tttacatata aacaaacaaa
    12181 aattgtatcc cgggctaaac ggcatcttaa agctatgaat gaggaactgg tcgggctgaa
    12241 taagaatctc gacgaagcta atctgatcaa ggaaaaatat gtggggtatt ttatgaatca
    12301 atgtgccgtt tatattaata aactcgatga gtacaggaag aatgtgaaca ggaaaatcaa
    12361 gaccggacag attgatgatt tatataagtc atcctcccga ccttttgaaa aggaacttga
    12421 agaactttat cataactttg ataaagcgtt ccttaatttg tatcctaact ttgtggaaaa
    12481 gttcaattct ttgttgaaac cggaggagcg ttataaactg gaaaaggacc aactgaatac
    12541 agaattacgc atatttgcat tgatacggtt aggaattacc gatgttggac agattgctgt
    12601 atttttgcat tattctgtgc agacaatcta taattataag agtaaagtga agagaatgtc
    12661 gactcttgat agtaatatct ttgaggagga ggtaaaaaag cttggttctt tgtctcaaaa
    12721 atgattctat ccggtttacc aacactaaaa aatgaaa
//
