LOCUS       c00133_gnlPro..        16296 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GFOGEDAG_133.
ACCESSION   c00133_gnlPro..
VERSION     c00133_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 07:38:46
            Original ID  :: gnl|Prokka|GFOGEDAG_133
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16296
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16296
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2747:6296](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2748..6296
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16296
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16296
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(172..1389)
                     /locus_tag="ctg133_1"
                     /transl_table=11
                     /translation="LNSFEMTKKALYIFNPEHDLALASGETNYMAPASARRMASELALL
                     PMWYAEEGSAVLAPSAYNLGYVKKIQELLGLSVDLMTEPELAIEPNLDIRPWGWDVALR
                     KRLSGLGMDEALLPSMEQLDGLREYSHRSKAVSLLPELQLNEYFCGESYYLKTQEEWKT
                     FVEERECCLLKAPLSGSGKGLNWCKGIFTPFISGWCTRVAASQGGIIAEPIYNKVEDFA
                     MEFYSDGTGEVTFMGYSLFHTGKSGMYEGNRLLSNEAIWKQLSQYVPSKVLTDLENCLK
                     YRLSALVGTVYKGYLGVDMMICRFPENEKPFFRIHPCVEINLRMNMGVVARFLYDRYVR
                     SDSTGRFVIDYHPSEGEALQEHERMSATYPLEIREGRVYSGYLPLVHVHRRSCYRAWIW
                     VTPDNI"
     CDS             1537..2715
                     /locus_tag="ctg133_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2748..6296
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg133_3"
                     /sec_met_domain="PFOR_II (E-value: 2.8e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.4e-82, bitscore: 268.6,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 2.9e-31, bitscore: 100.6,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.4e-12, bitscore:
                     37.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 1.2e-11, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 1.8e-08, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 9e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 7.1e-25, bitscore: 78.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQKALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDNPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     EQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTAKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAQAENWTYCAENVKTKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIAADCTPAEVKELFAEWINNMLDADKTKE
                     LAAKIIPVVEANKDKCNHCKQIAELQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGAE"
     CDS             complement(6307..6408)
                     /locus_tag="ctg133_4"
                     /transl_table=11
                     /translation="MNSSGKKGVLFMLDRVHTIKKTVIFYKITVLYL"
     CDS             complement(6450..7316)
                     /locus_tag="ctg133_5"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSGLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRQLVDSW
                     IPKSENK"
     CDS             complement(7337..8161)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg133_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 7.2e-29, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETVINWMMVHFSTFFDAINAGIGSFIIGFQHVLFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8158..9384)
                     /locus_tag="ctg133_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSRQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETHEFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9684..10022)
                     /locus_tag="ctg133_8"
                     /transl_table=11
                     /translation="MKDYKVDKASLSTSFCQEVYQVVREIPVGKVSTYGGIAALLGMPQ
                     CSRMVGRALKQVPDDLSTPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10105..11493
                     /locus_tag="ctg133_9"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGV
                     FAFSSCEKNLYDESKQPEKEIQVKDLDIPAGFQWKLTQVAAGTVAATTPTMVSFFLDEA
                     CSKEEKIADIPVDTEISSLPLSIPTYVNTLYAQYKTSTNETKKVAIPVNADRSFSLNIA
                     NDAKSKSNTTRSITRGHDIEDDIQLSKGVIFHPKDGWGTIMFEDQFPSLGDYDFNDFVV
                     NYKVQFQGIKKVDKKYTAQYIQIGLRLKAIGGIFPYSPYLRLKEIDSDEVESIEVYETK
                     NVIPAIDGVDLVPNKHLIIDYSPLIKNLAKPAGSQYYNTEKNALVATSDLPEINILITL
                     KKRKEVKEILEGDEFDLYLKRNDSGTEIHMNGIEPITYQYPFNDKNLLPVYTNGDEEDD
                     NYYFSAGRLIWGLRVPGNAAHAIEKANFLEAYKGFAKWAQSSGKNEQNWYNQGNADKSL
                     LIHN"
     CDS             complement(11574..14402)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 61.6; E-value: 2.8e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg133_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 2.3e-19, bitscore:
                     61.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMGYTKWIAVLLCLLGMTACRQDAPRFRIGVAQCSDDSWRHKMND
                     EILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDEGVDLLIISANEAAPMTPIVEEAY
                     QKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGSTPA
                     MERHQGFMAAISNFPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRIAPG
                     AYQAAKKVGREKEMIFVGIDALPGKGNGLEMVLDSVLNATFIYPTNGDKVMQLAMNILE
                     KKPYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQVVMY
                     GGLVILLLVAGLLLVVYKSLRAKNRLNKELSEQKKQLEEQRDKLEEQRDQLEEQRDKLE
                     EQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADHTLSGDQHRML
                     MLIQRNVNILLRLVNQILDFRKYENGKMEYTPVQVDVLSSFEGWNESFLAAARKKHIHF
                     SFDNMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGKITVRLSSLTKEDTRWIRFTV
                     ANTGSMISAEYIRSIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTISVESDEKQGTVF
                     TVDLPVQTCETILAEDSLKSSISAVPLNPASPGSPASSNQNETLAVEEEELEKGYDSSK
                     PSVLVIDDNADIRSYVRGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGI
                     ECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRNLID
                     SHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGLSRVQ
                     LYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCYREQF
                     GESPTDLLKRKG"
     CDS             complement(14836..15723)
                     /locus_tag="ctg133_11"
                     /transl_table=11
                     /translation="MNNIIVGMGEALWDVLPEGKKIGGAPANFAYHVSQFGFDSRVVSA
                     VGKDELGDEILNVFNEKKLKTQIEQVDYPTGTVQVTLDDEGVPCYEIKEGVAWDNIPFT
                     DELKRLALSTRAVCFGSLAQRNEVSRATINRFLDTMPDIDGQLKIFDINLRQDFYTKEV
                     LRESFRRCNILKINDEELVTISRMFGYPGIDLQDKCWILLAKYNLKMLILTCGINGSYV
                     FTPGVVSFQETPRVPVADTVGAGDSFTAAFCASILNGKPVPEAHKLAVEVSAYVCTQSG
                     AMPELPQVLKDRLM"
ORIGIN
        1 agatagaact ctactactaa gcgttttttc tttgttacta gagtaaataa aattccgatg
       61 catctaatat ctattcaaat ccggtgcaaa aaggaatata tttagacgcg gattacacgg
      121 cagaagcgac attgaagcag atcgacgata aaggctatct gataccgtaa gttaaatatt
      181 atcaggagtt acccatatcc acgcccgata acaacttctc ctatgaacat gaaccaaagg
      241 taaataaccg gagtacactc taccttccct gatttccaac ggataagttg cggacattcg
      301 ttcatgttcc tgcaaggctt caccttccga aggatgataa tcaatcacaa aacgccctgt
      361 tgaatcagaa cgtacataac ggtcatataa aaaacgcgca acaactccca tattcatgcg
      421 cagattaatt tccacacagg gatgaatccg aaaaaacggc ttttcatttt ccggaaaccg
      481 acaaatcatc atatcaactc caagataacc tttataaacg gttcctacca acgcagaaag
      541 tctgtatttc aaacagtttt ccaaatccgt cagaaccttt gaagggacat attgcgaaag
      601 ttgtttccag attgcctcat tagaaagcaa acgattccct tcatacattc cactctttcc
      661 ggtatggaag agggaatatc ccataaatgt cacttcacct gtaccatcgg aataaaactc
      721 catggcaaag tcctctacct tattatatat aggttccgca atgattccac cctgcgaagc
      781 agccacacgc gtacaccaac cggatataaa aggagtaaat atgcctttac accagttcaa
      841 gcctttaccg cttcccgaaa gcggagcttt caacaggcag cattcccgtt cttccacaaa
      901 ggttttccat tcttcttgtg tcttcaaata ataagattct ccgcagaaat attcattcag
      961 ttgtaattcc ggaagcaatg agacggcttt agaacgatgg gagtattccc gcaaaccgtc
     1021 taattgctcc atagaaggaa gcagggcttc atccatgccc agccctgaaa gccgtttccg
     1081 caaagctaca tcccatcccc aaggacgaat atccaaattc ggttcaatag caagttccgg
     1141 ctctgtcatc aaatcaaccg aaagtcctaa taattcctgt atcttcttca catagccgag
     1201 attataagcg gaaggagcta atacagcact cccctcctct gcataccaca tcggaagcaa
     1261 agccaactcg gaagccatac gtctggcaga agccggagcc atataatttg tttcaccgct
     1321 agccaacgcc aagtcatgtt ccggattgaa tatataaaga gccttttttg tcatttcaaa
     1381 tgaattcaaa actttattct gcaaatatat acaggaaata gtcaggaatg actacaataa
     1441 acagaaagtt ggaattaaac acacaatttt gccatctcta ctttgcaaat cctaaaaaaa
     1501 gcagtatatt tgccacccga aaaacaaaga actgaaatgg aatcattcta ccgcacacac
     1561 gcctacctcg ttgagcacac caatgccccc gttcgccgcg atcttatgga cgagatcgac
     1621 tggagcgacc gcctgattgg tatcaaaggg acacgtggcg taggaaaaac cactttcctt
     1681 ctccaatacg ccaaagagaa attcgggaac gaccgttcct gtctgttcat caacatgaac
     1741 aacttctatt tctcgggcca cagcattgta gacttcgcca acgaatttca gaaacgtggc
     1801 ggaaaagtat tgttgatcga ccaggtgttc aaacatcctg aatggagcaa agagttacgc
     1861 atgtgttacg accgttttcc taacctgaaa attgtcttca ccggctcgtc cgtgatgcga
     1921 ctgaaagaag aaaatcttga attacgtgat atcgccaaga gctataacct gcgtggattc
     1981 tctttccgtg aattcttaaa cttgcaaaca ggcatgaaat tcagggcata tagcctcgaa
     2041 gaaattctta gcactcacga acagattgcc aaaggagtac tctccaaagt tcgtccgttg
     2101 gactattttc aggattacct gcaccacgga ttctatccgt tcttccttga aaaacgtaac
     2161 ttttcggaga atctgctgaa aacgatgaac atgatggtgg aagtagatat acttctcatc
     2221 aaacaaattg aactgaaata tctttcaaag ataaaaaaat tgctatattt gctcgctgtc
     2281 gatgggccga aggctccaaa tgtgagccaa ctggcaagcg acatacagac atctcgcgcc
     2341 acggtgatga actatatcaa gtatctggca gatgcgcgac tcattaatct ggtttatccg
     2401 aaaggggaag aattccctaa aaaaccttcg aagataatga tgcacaactc caacctgatg
     2461 tattccatct atccggtgaa agtggaagag caagatgtgc tcgacacatt ctttgcaaat
     2521 tctttatgga aagaccataa ggtacataaa ggagataaaa acgtctcttt tatggtagac
     2581 gaagtaatgc cgttcaaaat ttgccaggaa ggcgcaaaga tcaagaacaa tccgaatgta
     2641 acgtacgcgt tgcataaggc tgaaataggt cggggcaacc agatacctct ctggatgttc
     2701 ggctttttat attaaaagat ttatttactt aaatatttaa tttagttatg actaaacaga
     2761 agaaattcat cacttgtgat ggtaaccagg ctgcagcgca tatctcgtat atgttctctg
     2821 aagtagcagc tatctacccc atcactcctt cttcgactat ggctgagtac gtagacgaat
     2881 gggctgccgc aggacgtaag aacatcttcg gcgaaacagt attagtacag gaaatgcaat
     2941 ctgaaggtgg tgctgccggt gcagttcacg gttctcttca ggctggtgcg ttgactacta
     3001 cttacactgc ttcccagggg cttctcctga tgatccctaa catgtacaaa attgccggtg
     3061 agttcttgcc ttgcgtattc catgtatctg ctcgtacatt ggcttctcac gcattgtgta
     3121 tcttcggtga ccaccaagac gtaatgtcag ctcgtcagac tggctttgct atgttggctg
     3181 aaggctctgt acaggaagtt atggatttgg ctggtgttgc tcacttggct accatcaaat
     3241 ctcgcgttcc gttcatgaac ttcttcgatg gtttccgtac atctcacgaa atccaaaaga
     3301 ttgaaatgtt ggaaaatgat gatcttgctc cgctgatcga ccagaaagct ttggctgaat
     3361 tccgtgcccg cgcactgaac ccgatgaaac cggtagctcg tggtatggct gaaaatcctg
     3421 accatttctt ccaacatcgt gaatcatgca acaactacta tgaagcagtt cctgctatcg
     3481 tagaagaata catgaatgaa atttctaaga tcacaggtcg taaatacggt ttgttcgatt
     3541 actatggtgc agaagatgca gaacgcgtaa ttatcgctat gggttctgta acagaagctg
     3601 cccgcgaagc tatcgactac ctggtagcaa acggcgaaaa agtgggtatg gttgccgtac
     3661 acctgtatcg tccgttctct gctaaacact tcctggctgc tgtacctaag actgctaaaa
     3721 ctatcgcagt tcttgaccgt actaaagaac cgggtgctaa cggcgaacct ctttaccttg
     3781 acgttaaaga ctgcttctac ggtgcagaaa atgctccggt tatcgttggc ggtcgctacg
     3841 gtttgggttc aaaagatact actcctgctc aaatcctttc agtattcgaa aacttggcta
     3901 tgccaatgcc gaagaaccac ttcactatcg gtatcgtaga cgacgttact ttcacttctc
     3961 ttcctcaaaa agaagaaatc gctttaggcg gcgaaggtat gttcgaagct aaattctacg
     4021 gtttgggtgc tgacggtaca gtaggtgcta acaagaactc tgtaaagatt atcggtgaca
     4081 acactgacaa acactgccag gcttacttct cttatgactc taagaagtcg ggcggtttca
     4141 cttgttctca cttgcgtttc ggtgacaatc caatccgttc tacttatctg gtaaatactc
     4201 cgaacttcgt tgcttgtcac gttcaggctt acctgcacat gtacgatgta actcgtggtt
     4261 tgcgtaagaa cggttctttc ttgctgaaca caatctggga aggtgaagaa ctggctaaga
     4321 acctgcctaa caaggttaag aaatattttg cacagaacaa catttctgta tactatatca
     4381 acgcaacaca aattgcactg gaaattggtt tgggtaaccg taccaacaca atccttcaat
     4441 ctgcattctt ccgtatcaca ggcgttattc ctgtagaaca agctgttgag cagatgaaga
     4501 aattcatcgt taagtcttac ggcaagaagg gtgaagacgt tgttaacaag aactatgctg
     4561 ccgttgaccg tggtggtgaa tacaagactt tggctgttga tcctgcttgg gctaaccttc
     4621 cggatgacgc aaaagctgaa aacaacgatc ctgcattcat caacgaagta gttcgtccga
     4681 tcaatgcaca agacggtgac ttgttgccgg tatctgcatt caagggtatc gaagacggta
     4741 cttggtatca aggtactgct aaatacgaaa aacgtggtgt agctgcattc gttcctgaat
     4801 ggaatccgga aaactgtatc cagtgtaaca agtgtgcata cgtttgtcct cacgcttcta
     4861 tccgtccgtt cgtactcgac gctgaagagc agaagggtgc taagttcgaa caactgaaag
     4921 ctgtaggtaa agcattcgac ggtatgacat tccgtatcca ggtggacgtt ctcgactgtc
     4981 tgggttgcgg taactgtgcc gacatctgtc cgggtaatcc gaagaagggt ggcaaagcat
     5041 tgacaatgaa acacctcgaa agccaattgg ctcaagctga aaactggact tactgtgctg
     5101 aaaacgtgaa gactaaacaa catcttgttg atatcaaggc taacgtgaag aactcacagt
     5161 tcgctactcc gttgtttgag ttctccggcg cttgctctgg ttgtggtgaa actccatacg
     5221 tgaaattgat ttctcaattg ttcggtgacc gtgaaatggt tgctaacgct accggatgtt
     5281 cttctatcta ctctggttct gttccttcta ctccgtatac tacaaacgaa aacggacacg
     5341 gtcctgcttg ggctaactca ctgttcgaag acttctgtga attcggtttg ggtatggaac
     5401 tggctaacga aaagatgcgt gctcgtctcg tgaaagtgat gaacgaggct attgctgctg
     5461 attgcactcc tgctgaagtg aaagaactgt tcgctgaatg gatcaacaat atgctggatg
     5521 cggacaagac taaggaattg gctgctaaga tcattccggt tgttgaagct aacaaggata
     5581 aatgtaacca ctgcaaacaa atcgctgaac tgcaacaata tcttgtaaaa cgcagccagt
     5641 ggatcattgg tggtgacggt gcttcttacg atatcggtta tggtggtctt gaccatgtaa
     5701 tcgcttccgg taaggacgtt aacatcctcg ttctggatac tgaagtttac tctaacacag
     5761 gtggtcagtc ttctaaagct actccggtag gtgctatcgc taagttcgct gctgctggta
     5821 agcgcgtacg taagaaagac ctcggtctga tggctactac ttacggttat gtatatgttg
     5881 cacagatcgc tatgggtgct gaccaagctc aaactctgaa agctatccgt gaagctgaag
     5941 catatccggg accatctttg attatcgctt acgctccatg tatcaaccac ggtctgaaag
     6001 caggtatggg taagagccag gaagaagaag aaaaagctgt taagtgcggt tactggcact
     6061 tgtggcgtta caacccggct ttggaagaag aaggcaagaa cccattccaa ttggatagca
     6121 aagaaccgaa ctgggaagat ttccaaggtt tcttgaaggg tgaagttcgt tacgcttctg
     6181 taatgaaaca atatcctgct gaagctgaag aactgtttaa agctgctgaa gaaaacgcta
     6241 aatggcgtta caacagctac aaacgtttgg ctagagaaaa ctggggtgct gaataatagt
     6301 aataccctat aaatataaaa cggtaatctt gtagaagatt accgtttttt ttattgtatg
     6361 aactctgtct aacataaaca atactccctt tttcccacta gagttcatgt ctattttata
     6421 tttaaaatta agaataacaa tgctccaatc tatttattct cagacttcgg aatccaacta
     6481 tccaccaact gccgatgttc atccctccat ttgcgggcta tttcttcttc atccatccgg
     6541 gcatccttca tagctgtcat aaaagagcta agttcttctg tcgttagttt aatgttgcca
     6601 aagaattcgg cagcaaacgg atctttctca ctgaatcctt tccatgcaat agcatgtatt
     6661 tcttccaagt ctccatatac tttcttcgga tcatccaaga atttcaagtc aaactggtcg
     6721 aacatccaat gcggtgtcca ccccgtaatg acaatccatt ctcctttgtc catcgctttt
     6781 ttcaaagaag ccagcatggt ggaactactt gaagtcatga gggtataccc atcaagtccg
     6841 taagcagcaa tggccttatc ggtcgtcttc attatccctg ctcccgcatc aattcctact
     6901 atttcggaag aaaaacggtc tttgttagct tccagctcac taatagactg gatcgtaaca
     6961 tattgaggaa caaccagtcc tacacgggct tctccatata cctcccccaa aaattcgatg
     7021 ctgtctccat actgatccat ataatctttc atcgttattg gtaaccatgc atccagaaag
     7081 acatcagatt tctttcctga catagataca aaaatagggg caagatcagc attttgcaat
     7141 tcaacctcat atccatgctc ttccaatacc accttggcca aatgactcat ggcaatacct
     7201 tccagccaat tggcataggc tatttttact ttctttttct ctaagcctga attagtacag
     7261 gaagctagca aaagcatagc tgacaatact attcctacta ttttatatat tctcatacgt
     7321 attttatcct ttccgtttag ttcttatttt ttcgtcctgc cattccttgt gtgatacggt
     7381 ctaagataat agctaaaata acaactgcta taccaccttc aaacccaagt ccgattttca
     7441 tttgggtaat acctttcaat acaatttctc ccagaccacc ggcagcaatc atggcagcaa
     7501 tgacaaccat agaaagcgac atcattattg tctggttgac accagtcagg atagtgggca
     7561 acgccaaagg aagctgcact ttatacaata actgccaacg ggtagctccg aacgaacggg
     7621 aagcttccac tacattttta ggaacttgcc gtattcccaa tccggtaagg cggaccacag
     7681 gaggcatagc aaagataatg gtggcaaaca ctcctggcac tgctcccaat ccgaaaaata
     7741 aaacggcagg aatcagataa acaaaagcag gcatcgtctg catcaagtcg agaacaggac
     7801 gaagtatttt ctctgcacgc ggactgtttg ccgtccacac tcctaaaggt acaccaacaa
     7861 tcagggccag acaggtagat gaaaaaacaa gagccagggt ttgcatagta gcctcccaaa
     7921 atcccattcc ataaatcagt aataatccca atgcggtgaa aattgccgta ccacgtcctg
     7981 ccttcatcca tgcgagtgca gcaagcacta gaatggttat ataaaaaggt attccaaaaa
     8041 gtacgtgttg gaatcctata ataaaactac cgatgcctgc atttatggca tcaaagaaag
     8101 tggaaaaatg taccatcatc caattgatga ccgtctctat atattgtcct atatttatca
     8161 taaatctatt gcgttttgaa ttatttcgtt tatttcttct ttatctttcc ccgtcacttc
     8221 gatgattaag gaggaaagcg ggattgttcc taaaaactca tgcgtctcat caatcaccca
     8281 taccggcgaa ttgctctttg tcattaaagg aagtatatcc tccaacactg tatcctccaa
     8341 tacagaatgt acttcggtac gcacaatcgt ttcaatggat ttttcctgtc tgctacgtaa
     8401 cttaagcagg tcgttcagac gtacttctcc gaccagttta tcatcggcgt ctatgacagg
     8461 taatacggtg atattcttcg cacgcatctt acgaatcaat acttcaggtc cctctttctt
     8521 cagacgggcc accagtggtt tgtcaatcat taaagaagaa gcggtaataa ttttactcct
     8581 gtccacgttt tcaacaaaac gggctacata atcgttagcc ggttcggtca gtatttcttc
     8641 tgaagtacct acctgcacca cctctccgtc tttcataata gcaatacggt cgcccagttt
     8701 aatcgcttca ctcaagtcat gggtaataaa gacaattgtt tttttcatct tcgactgcaa
     8761 agccagcagt tcatcctgca tttgcacacg aatcagagga tcgagcgcag agaaagcctc
     8821 atccattaga agtacttcgg gattattagc cagagcgcgg gccagtccga cacgctgttg
     8881 cattccaccg gaaagctcgc ccaccatctg attttcatat cctttcaatc cgacaagctt
     8941 catgctttcc atcgctttct tctcacgttc ctctttcttc actccctgaa gttcgaggcc
     9001 gaacgcgata ttgctcaata cggaacggtg aggtaacaga ccgaaattct ggaaaaccat
     9061 cgccagctct ttccgacgaa cctgcaataa ttctttttcg gaaattttag atatatctac
     9121 tccgtttaca agcacttgcc cggtagtagg acgtatcaga cgattgatac aacgcagtaa
     9181 tgtcgatttt ccacttcccg agagtcccat tatcacgaaa aactctcctt cattaattga
     9241 aagattggca tctttcactc ctaccgtaca accggtatct ttcagaattt cctctttact
     9301 cttatctttt ttcaacatct tgagggcttt ctgcttctcg ttaccaaaga taaggtacaa
     9361 atcctttatt tctattttac tcatataata tattggttta gattataata tttgttttgt
     9421 tttcaactgc cgcattcctt attctcactt acgataaaca agttgaatgt tcgcatggtt
     9481 cagtcatgtc acatgataac atgacggtcc gacgtttttt aaatggttta aaaaaaacag
     9541 acagagtagt ttaaaaggaa tagaatttga taagattatc ctcttaatga acagtagaaa
     9601 acagtatttt cataaataaa taacagtctg ttcttgcata ttgttggcac aaaggtaagg
     9661 aaaatagatt aaatatgcaa atttcattca ggtacggagt aattccaaag atgctttttc
     9721 aagtctacgc atccattttg cttgaaagag atcccttctt ccaacaagag ttgtttctgc
     9781 tctgtccacc ccggaacaag gcgtcccgat gcattgacaa cccggtgaca aggcgtagat
     9841 aaatcatccg gaacctgttt caaggcacgc cccaccatac gggaacattg aggcattccc
     9901 aataatgcgg caattccccc ataggtagaa actttaccta ccggaatttc ccgaacaacc
     9961 tgatacacct cctgacaaaa ggatgtggaa aggcttgcct tatctacttt ataatctttc
    10021 atcgcctgga ctttatttat ttcattccca aagctagata aaaagaagag aatttgcaaa
    10081 taacaaaagc atttcaaata aaatatgcaa ctttatttgc tttatttaca aataatcccg
    10141 acctttgtac ccattaaaag caaccctatt attaacaaaa caagcactgc tgttatgaaa
    10201 aagaagacaa ttctattcgc ttcttgttta ttgggagtat tcgctttcag ctcctgtgag
    10261 aagaaccttt atgatgaaag caagcaacct gaaaaagaaa ttcaagtaaa agacctggat
    10321 atacccgcag gctttcaatg gaaattaact caagtagccg caggaacagt agctgctact
    10381 acccccacta tggtttcctt ctttttggat gaagcatgta gtaaagaaga gaaaatagcc
    10441 gacattcctg tagatacaga aatttcaagt ctccctttga gcatcccaac ctacgtaaat
    10501 acattgtatg cccagtacaa aaccagcacc aatgaaacca aaaaagtagc catacctgta
    10561 aatgcagata gaagtttctc actgaacatt gctaatgatg ccaaatccaa atctaacacc
    10621 acccggtcaa tcactcgtgg gcatgatata gaagatgaca tccaattgtc aaaaggagtc
    10681 atttttcatc ccaaagatgg ttggggaaca atcatgtttg aagaccaatt tccatcatta
    10741 ggagattatg actttaatga ttttgtagtc aattataagg tgcagttcca aggtattaaa
    10801 aaggttgaca aaaaatacac tgcgcagtat atacaaatag gattacgtct aaaagctatc
    10861 ggaggaatat tcccttattc tccttattta agactgaaag aaatagattc tgacgaagtg
    10921 gaaagtatag aagtttatga aactaaaaac gtgattcctg cgatcgacgg agtagatctt
    10981 gtccccaata aacatcttat cattgattac agccctttaa ttaagaatct ggctaaacct
    11041 gcaggcagcc aatattataa tacagaaaag aatgctttgg tagcaacaag tgatttaccg
    11101 gagatcaata ttctgatcac cctaaagaag agaaaagaag taaaggaaat attagaaggc
    11161 gatgaattcg acttgtattt aaaacgtaat gatagcggaa cagaaatcca tatgaatggt
    11221 attgaaccga tcacttacca atatccattc aatgataaaa atctgctacc ggtatataca
    11281 aacggggacg aagaagatga taattattat tttagtgcag gacgcctgat ttggggatta
    11341 agagtaccag gcaacgcagc gcatgctatt gaaaaagcta atttcttgga agcctataaa
    11401 ggattcgcaa aatgggcgca aagtagtggc aaaaacgaac aaaactggta taaccaagga
    11461 aacgcagata aaagtttatt gattcataac taacacatat caataaatcc cggtaaacat
    11521 tgaaaattca agttaccggg atttattgta ttctgacgtg aatagttttg attctatcct
    11581 ttccttttca gcaaatctgt cggactttca ccaaactgct ctctataaca tttggtaaaa
    11641 taagaaggag aactaaaacc gacttcataa ccaatctccg ccactgtcat atctgacgaa
    11701 gcaagcaggg aagcagcctt cttcaagcga gcgatgcgaa gcaattcatt cggagaataa
    11761 ttagtcaggg attttatttt gcgatagagt tgcacacgac ttaatcccat atccttaccc
    11821 aaatcctcta cattcaaatt tgaatctccc atctttgctt caattaaagc cttgaatttt
    11881 tccacaaagt ctttatccat atcacagaca tcctctttcg ccaacgtttg tccgtcacca
    11941 aagaactgtt tcaggcggcg atgtgaatct atcagattac gaacgcgtgc caacagcaat
    12001 tgcgaactga agggcttgga gatataagaa tccgcacctc cgtcatatcc ctgaatccgt
    12061 tgttcatcca aagaacaggc tgtcaatagg atgacaggga tatggcaggt ttgcagttcg
    12121 cttttcagcc gacggcaaca ctctattcca tcaataccag gcatcatcac atcagagatt
    12181 atcaagtccg gaacatattt cattgctttg cggataccct ccgaaccgtc tgctgcttca
    12241 ataacagtat aatcggtatg gagtaatccg cgtacatacg aacggatatc tgcattatca
    12301 tcaattacca aaacagaagg tttggaagaa tcatagcctt tttccagttc ctcttcttcg
    12361 acagctaaag tttcattctg gttggaagag gcaggagaac cgggagaagc aggatttaaa
    12421 ggaactgcag agattgatga ctttagagaa tcttcggcca gaatagtctc acaagtctgt
    12481 accggtaaat caacggtaaa gacagtgccc tgcttttcat cactttccac agaaattgta
    12541 cctttatgca attcaacgaa agctttaacc agtgcaagcc cgattcccga accggcgtgg
    12601 tgcatgtcta ttttataaaa acgatcgaaa atactccgga tatattcggc ggaaatcatt
    12661 gaaccggtat tggcaacagt aaaacgaatc cagcgagtat cctctttcgt caaggaagat
    12721 aaacgaaccg ttatctttcc attttccggt gtgaacttga acgcgttgga aagcagatta
    12781 aaataaatac gttccaactt ttccatatcc gccaacgtat ggtaatccgt atccggcata
    12841 ttatcaaaag agaaatgaat gtgtttcttc cgggcggctg caaggaatga ttcgttccag
    12901 ccctcaaaag aggaaagaac atctacctga actggtgtat attccatctt accgttctcg
    12961 tatttacgga aatccagaat ctgattaaca agacgcaaaa ggatattcac gtttcgttga
    13021 atcagcatca acattcgatg ctgatctcca cttagtgtat gatcggccaa taaatgttct
    13081 accggatcgg caaccaatgt cagcggagta cggaaatcgt gagatatatt tgtgaagaaa
    13141 accagtttgg catgcgttgc ctcttccagt tgatgagaaa gctggatgag ctgatcccgt
    13201 tgctcttcca gtttgtcccg ctgttcttct aattggtcgc gttgttcctc taacttgtcc
    13261 cgctgctctt ccaactgttt cttctgctcg gaaagttcct tattcagacg atttttagca
    13321 cggagagatt tatagactac caataataag cctgccacca atagaagaat gaccaaaccg
    13381 ccatacatca ccacctgctg tgtagcaaca cgagacagat atccgccgat acgtccgttc
    13441 aatgtttcaa tcttctgatc cagttccgag atgtgagttg tctgaagttg catgacatgc
    13501 gcattcgtac ggtcgaccac cgcagtgttc atgaccgttt cccggggata aggctttttc
    13561 tcaaggatat tcattgccag ttgcatcact ttgtcgccat tggtcggata aataaaagta
    13621 gcattcaaca cactgtcgag caccatttcc aatccgttgc ctttgccggg gagagcatcg
    13681 ataccgacaa aaatcatttc cttctcccgt cccactttct ttgcagcctg ataagctccc
    13741 ggagcaatac ggtcattatg cgcatacacg gcgtctatct tcggatgccg acggagcata
    13801 ctatccattt ccacttccgc cggttcacgc tcccacgcag catccgcttt atcaatcagt
    13861 ttgatatccg gaaagttact gatagcagcc ataaatcctt gatggcgttc catggcagga
    13921 gttgagccac ccagtccggt aagttccacc acattccctt ttcctttcag gcttgacgca
    13981 atataattgc ctaccgcacg tcctatttca taattgtcgg caccgatata ggcagtatat
    14041 ttatcagaaa gaatcttccg gtctaccagg atgacaggta ttcccttttg ataggcttcc
    14101 tctacaatcg gagtcatggg ggccgcttcg ttggcagaga taatcaataa gtcaacccct
    14161 tcatctataa aataatgaac gtcttccgcc tgtttgcgat tatcatccgc agccgaccgg
    14221 atttcaaccg ataccccatc gtagaacatt gcttcgcgaa gaatttcatc attcatctta
    14281 tgccgccagg agtcatcact acattgcgcc accccgatac ggaaacgcgg tgcatcctgc
    14341 cgacaagccg tcatgccaag aagacagagc aagactgcta tccactttgt atatcccatc
    14401 attctaatca ttctcatttt ttttcgtatt tctttctatg acccaaatgg acgattgaga
    14461 acaaaaataa gaaataaaac tgtgagtatg ctatctatca cccaattatt ctcatcatta
    14521 ccctccaaag aaatgcaaaa cagttcccaa tattcaagcg gaaactatta acaaaagtat
    14581 aaagcgtaag acaaacactc aataaatgtt ataaaacatc tctttttatt tggattattt
    14641 gcagatttag cagaagtccg tatctttgca atgtgttttt catagtatta gatttaaggt
    14701 taacaaaggt tggagcaagg cgttgctcct ttttttatac ccctacctct catatcatac
    14761 gaatcatgca aaaagaacaa gaggtatatt cccacggaat gagatatacc tctatactta
    14821 ctttccatca aacaattaca ttagtctgtc tttcaaaacc tgcggaagtt cgggcattgc
    14881 accgctttgc gtgcagacat aagcagaaac ttcaacagca agtttgtgag cttcgggaac
    14941 cggttttcca ttcaaaatgg aagcacagaa agcagccgta aaggaatcac ctgcccccac
    15001 cgtatcggca accggaactc tcggtgtctc ctggaaagag acaacacccg gggtaaacac
    15061 ataactgcca ttaattccgc aagtcagaat cagcatcttc aggttgtatt ttgccaacag
    15121 aatccaacat ttatcctgta agtcgatgcc gggatagcca aacatacggc tgatggtcac
    15181 cagttcttcg tcgtttatct tcagaatgtt gcaacggcgg aaagattcgc gcaatacctc
    15241 tttggtgtag aagtcctggc ggagattaat atcaaagatt ttcagttgtc cgtctatatc
    15301 gggcatcgta tccagaaaac ggttgatagt ggcacggctc acttcattac gttgagccag
    15361 ggaaccgaag caaacggcac gcgtactcaa tgccaaacgt ttcagttcat ccgtgaaagg
    15421 tatgttatcc catgccacgc cttctttgat ttcgtaacaa ggcacaccct cgtcatccag
    15481 tgtcacctgt accgtaccgg taggataatc cacttgttca atctgcgttt tcagtttctt
    15541 ctcgttgaat acgttcagaa tctcgtctcc cagctcatcc ttgcccacgg cactcaccac
    15601 gcgactgtca aaaccaaact gtgatacatg ataggcaaag tttgccggag caccacctat
    15661 tttctttcct tcgggcaaca catcccaaag tgcctcgccc attcctacga ttatattatt
    15721 catgatctac ggattttatt gtttccaaag ttataaaatt attttttaat acggaacgta
    15781 tagaacaaga gataaagcac gcccactgtc attacggcta ctgccccact ctgtcccatg
    15841 gcatcggatg ctactcccat agccaacgga aataccgtgc cgccgaacag tcccataatc
    15901 atcagaccgg aaacttcatt tttcttaccc ggcaggtaaa gcaatgcctg cgagaagact
    15961 acggagaaca cattggaatt gccgaaacca atcagaccga tacatacata aatcattgtc
    16021 ttgtcatgga atataaacaa acctgccatc gctatcagca tcatcacaac gctaatgccg
    16081 aagaaagact tcggtgacat cttacgtaaa atgaaagaac cgaggaagca gcctgccgta
    16141 cggaagatga aataaaggct tgttgcaaaa gccgcatcat caaggcccat gccgagacgt
    16201 tccatcaaaa tcttgggggc agtggtattt gttcccacat caattccaac gtgacacatg
    16261 ataccgatga aagaaagcag gataaacggt ttgcca
//
