LOCUS       gnlProkkaKADGHDLE_9    14286 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KADGHDLE_9.
ACCESSION   gnlProkkaKADGHDLE_9
VERSION     gnlProkkaKADGHDLE_9
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 01:58:40
            Original ID  :: gnl|Prokka|KADGHDLE_9
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 48242
            Orig. end    :: 62528
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14286
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9286]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9286
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14286
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14286
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(223..1056)
                     /locus_tag="ctg9_41"
                     /transl_table=11
                     /translation="MAIAYDGINYFPVGVNFMEENAMEVIEAKYGIKGSAIVLKLLCKI
                     YKEGYFIHWDEEQCLIFANKAGREVQAAEVQGIIEILFIKGILDRNSYLANGILTSANI
                     QKIWMEATKRRKRDLKALPYLLVNDLTQQETEAPEGENVTISPGNVVHDVAVNAKNACN
                     SGQSKVKEKKAEENKELPPSAPPKGKEKEWEEVSAPLPIPGYAFNTMTHNYPGLTDTLK
                     RLGITEAGEVNAILRLSDYGRKGTRVWQLIANTCWSDIGAKGRYLIAALNKAKRK"
     CDS             complement(1195..1452)
                     /locus_tag="ctg9_42"
                     /transl_table=11
                     /translation="MCAEWMAERLEALTDHLQYGHAAIAYQKQNGDFKLVKATLIYYEA
                     EFHKKYDPTQIEGAVVYWNVDEQRWTTFQMENFMEWRPIV"
     CDS             2738..3169
                     /locus_tag="ctg9_43"
                     /transl_table=11
                     /translation="MRYEYVFRGERKIRKLVPVVHNLVFVYATRSEVDEMKSTVGASLP
                     IRYIMDRETRQPITIPEVQMRSFIAVAGNYDEQVVYLDPSVVSMKKGDRVRVTGGIFEG
                     VEGEFVRIKGDRRVVVSIQGVMAVATAFIHPSLIELIKN"
     CDS             3228..3713
                     /locus_tag="ctg9_44"
                     /transl_table=11
                     /translation="MLSLQSEIDSLCAVSHELLHLGLDGEPIYSDRFRQLNTDVYHRCE
                     HLFGSHGRTLEEEASLCIALLTGYNATIYNHGDKEDKIQSVLNRSWDLLDTLPVSLLKC
                     RLLVACYAEVFDEELAAEAHAIIDGWKDRELTREEFEIVEHLKSLEANPYPYSELHE"
     CDS             3710..4993
                     /locus_tag="ctg9_45"
                     /transl_table=11
                     /translation="MIRSLLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             5001..5705
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_46"
                     /sec_met_domain="NTP_transf_3 (E-value: 1e-14, bitscore:
                     47.3, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIER
                     IILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLV
                     FERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGI
                     HKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEAD
                     LSYAEEHIIRYC"
     CDS             5725..7026
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_47"
                     /sec_met_domain="CTP_transf_like (E-value: 8.4e-12,
                     bitscore: 37.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 6.1e-122, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3e-64, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVFEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             7038..8174
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_48"
                     /sec_met_domain="TPP_enzyme_N (E-value: 9.9e-22, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.3e-20, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             8171..9286
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 2.8e-33.
                     Score: 107.2. Matches aSDomain:
                     nrpspksdomains_ctg9_49_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 79; E-value:
                     5.6e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_49"
                     /sec_met_domain="Aminotran_5 (E-value: 2.4e-30, bitscore:
                     97.7, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLLHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHD
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIVGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMKEAQSFVCDDNI"
     aSDomain        8261..9049
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg9_49_Aminotran_5.1"
                     /evalue="2.80E-33"
                     /label="ctg9_49_Aminotran_5.1"
                     /locus_tag="ctg9_49"
                     /protein_end="293"
                     /protein_start="30"
                     /score="107.2"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLLHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHDAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIVGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             9452..10813
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_50"
                     /sec_met_domain="Polysacc_synt (E-value: 1.1e-11, bitscore:
                     36.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFRNKIFIFLQKGSDRSVNIKKNVAGSLCLKVINIFISLQVVP
                     LTIHYVNPSKYGVWLTLSSIIAWISYFDFGFAHGFRNRFAEAIAKGEFLLARKYVSTTY
                     AVLFILFSIICVILLGLNSFLDWTRILKLEPSLILELRVLMQILICFFCLYIVANIFTT
                     MLTAYQKPALASLINTGGQVFAFIAIYLLTKFTSGSLINLAFAFSGIPCLVLIIVSVFV
                     FSTKRYSAFAPCIRYVNFRLTRNIIGLGGKFFIIMISMLFSLQFINIIISRIQGPDAVT
                     QYNIAYKYFSIINMIALIILTPFWSAFTDAYVKKDFGWMAVVVKKLERLWLLCIPAVVI
                     MIICSEVAYAFWIGNSVHINMKLSIIVSLYVLFQTLGSTYMYLINGTGKVTLQMILYIC
                     FAFVSIPLMSLCCEKLGTIGAVVVPCIIIFIQAIVGKIQINLIVNQKAYGLWNK"
     CDS             10842..11597
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 75.3;
                     E-value: 8.3e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_51"
                     /transl_table=11
                     /translation="MGVMKFILLKSISFSEKCNNIFWRRFNVFLFKLNGVVLRDRPVIR
                     NKVFLKMNSNSTFVIGNKFRFISGSNLNPLSSNIVGSIFLSEGSKIIIGNNVGISSSVL
                     VSFKEIIIGDNVLVGAGCLIMDTNGHSLNPFERRMEAETHAGRTGQGIIIDSDVWLGTN
                     CSIYAGVHIGRGAVVAGNSVIRNDIPPYAVVLGNPAKIISFVFSPEEIVELEKKNYPKD
                     ERIPLEVLEKNYNKYYINRFKEIKQFLKL"
     CDS             11619..11849
                     /locus_tag="ctg9_52"
                     /transl_table=11
                     /translation="MELKEFVAQFAEQFDETEISEIQSDTVYKELDEWSSLTSMSIIAF
                     VKTVIGKNVTMTDFKNAETVEDLYNVILSKK"
     CDS             11851..12603
                     /NRPS_PKS="Domain: PKS_KR (13-167). E-value: 2.5e-14.
                     Score: 45.5. Matches aSDomain:
                     nrpspksdomains_ctg9_53_PKS_KR.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     173.4; E-value: 9.9e-53)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_53"
                     /transl_table=11
                     /translation="MKEVNPFSLLGKKILVTGASSGIGKSIAIACAGMGANLYITARSK
                     KKLNITLEEMLEEGEHKAIIADLTKQEDIERLCQSLPKLDGIVHCAGVGSRVLCKNLTE
                     ADLKEVFLPNVEAPILLQSSLLSRKKINKEASIVFIASRAARIPSMGNAAYSATKGAIL
                     SYARCLALELAPQLIRVNSVCPAMIWTDLILQEGVERETLEEAEKKYPLKRYGYPKDVA
                     YLVLYLLSDASSWMTGSAVDLTGGAIEL"
     aSDomain        11890..12351
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg9_53_PKS_KR.1"
                     /evalue="2.50E-14"
                     /label="ctg9_53_PKS_KR.1"
                     /locus_tag="ctg9_53"
                     /protein_end="167"
                     /protein_start="13"
                     /score="45.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ILVTGASSGIGKSIAIACAGMGANLYITARSKKKLNITLEEMLEE
                     GEHKAIIADLTKQEDIERLCQSLPKLDGIVHCAGVGSRVLCKNLTEADLKEVFLPNVEA
                     PILLQSSLLSRKKINKEASIVFIASRAARIPSMGNAAYSATKGAILSYAR"
     CDS             12619..13617
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 276.1; E-value: 5.9e-84)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_54"
                     /sec_met_domain="fabH (E-value: 7.6e-76, bitscore: 247.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIYIKAVSLYLPKKVITNEDLVREFPEWSVEKVAKKVGVNSRHVA
                     EENETAGDMAEKAALRLFKEYDIEPKSIDFILLCTQSPDYVLPSTACILQHRLGIPTTA
                     GAFDYNLGCSGCIYGLALAKGLIAGGIAKNVLILTAETYSKYLHSSDKSYRSIFGDGAA
                     ACLVSTEGFAEIGNFSLGTDGSGAEKLIVKTGGARHKNITGFSTIDDEGHICFDDYLYM
                     DGGGIFNFTLDAVPAMMKDILSKNDMEKNDVDYFVFHQANKFMLNTIRKVCVLPKEKFY
                     VNLYETGNTVSSTVMIGLKDCINAGEIKEGMKVMIAGFGVGLSWGGVILKF"
ORIGIN
        1 aagtcttttg catttaaaga atttgctatt tgcagacgaa aaacgaactt taacgtaacg
       61 ttaaaataaa gcttctgcag attgaaatat tgtgctctga agtggctgta gatcatttgt
      121 ttaaatgtat gtcccgtttt ccattcccga cagagaacct tccgtatgga aaccggtata
      181 cttgcttttt tatcaactgc caactgtact ttcctatccg gattattttc tttttgcctt
      241 attcagtgct gctatcagat accttccttt tgcccctatg tcactccagc aagtattggc
      301 aatcagttgc catacccgtg ttcctttcct tccataatcc gatagcctga gtatggcatt
      361 cacctctcct gcttcggtaa tccccagtct tttgagtgta tccgtcagtc ccggataatt
      421 gtgtgtcatt gtgttgaagg cgtatccggg tatcgggaga ggagcagaaa cctcctccca
      481 ttctttttcc ttccccttgg ggggagctga ggggggtaat tctttatttt cctctgcttt
      541 cttttctttt actttacttt gtccggaatt gcatgcattt tttgcgttaa cggctacatc
      601 atgtactaca tttcccgggc taatggttac attttcacct tccggcgctt ctgtttcctg
      661 ctgagtcaag tcgttcacca gcagataggg caatgctttc agatcccttt ttcttcgctt
      721 tgttgcctcc atccatatct tctgtatgtt tgccgaagtc agtattccgt ttgccagata
      781 actgtttctg tccaatatcc ctttgatgaa gaggatctca atgatcccct gtacctcagc
      841 ggcctgcacc tctcttcccg ccttgttggc aaagatcagg cactgttctt catcccaatg
      901 gatgaagtat ccctctttgt atattttgca cagcagtttc agtacgattg ccgaaccctt
      961 tattccatat ttagcttcta tcacttccat tgcgttctct tccatgaagt ttacgcccac
     1021 cgggaaatag ttgatcccgt catatgctat tgccattgtt ttttagatta gtcgtttgta
     1081 ctttcaataa tacattcacc ataaattacc ccggattccc aaagatgtct tcacttgatt
     1141 tctcaaaata aaaataattc atcggtgaaa atccgtgtaa tctgtggtgg cgccctatac
     1201 gatcggtctc cactccatga agttctccat ctggaatgtc gtccatcgct gttcatccac
     1261 attccagtag actactgcgc cttctatttg tgtgggatca tactttttgt ggaattccgc
     1321 ttcatagtag atcagtgtcg ctttcaccaa cttgaagtct ccgttctgct tctgataagc
     1381 gatggctgcg tgcccgtatt gcaggtggtc ggtcaacgct tccaggcgct ccgccatcca
     1441 ttcggcacac atttcagtgt atcctttctc aaagacaatc cgttttttcc atctcagttt
     1501 catggcttca gtttgtgatg ccggtctttt cttctgtttc atacgtatat gatttaaagg
     1561 gttaatagat aaattatcgc cccaaaggta agtcggatcg aatgtattcc ggtttgataa
     1621 aattcattgt aggtatttca gcgctttcct tcttggttct ttttctttct ttccatctta
     1681 ttccagattt cgttgacgta agttctgatt gtgcttaaaa ctaatggctt gaatactcca
     1741 tttcttattt ttccaaaaag tttttttccc tctatgtagc gtgccaacga atctttgcat
     1801 gtcttgatat tttgttcttt tgcgtccaat atgtaggatt ctatcagcgc ttttataact
     1861 ccttcattgt tggagataat tcccggtatc tgcgctcctg cttttctgcc tcttgtttct
     1921 ttaatagctt ctgtgatagg aggttgtgtt ttagtgttag cgttttttta cacttttgtt
     1981 cactgtctgt aataattcat tttctttgtt catgattttt ttatttaatc aataattaaa
     2041 tgttgttaat atgttgcaaa ggtagagagt aatctttcag taggcaaatg aatgtggaat
     2101 taaaggggga ataaaaggga aaatgaaacc ttttctcttc ttaattgtct gacattaaat
     2161 gaaataattc ttaaaaaagt gagtgtttca ataaacgatc gtctaattga acgcaaagat
     2221 agagggtatt ttcataactg caaaatgttt aataaaaaaa atgttttcct tcatggcttg
     2281 atctatttaa ttatttgata atcaaatgtc tataaactaa caaaaaacgc tttaatatct
     2341 gtctgctttt atatgtattt taattgtctg gatctttaaa aaagtgtgtt tcaaaagacg
     2401 atcgtctatt gaaacacttt cgcttcataa tagactcgtt tacagattgt aagatcagta
     2461 aagccctgtt ttttcaaaac ttcgttttct gttcttcttt ttcaaactgt ctctcctgcg
     2521 ataggggagt acttgatgaa atgatatacg ctgcaaggca aacaacagaa ttagcaaact
     2581 tgaccggaag gtgtttcact accccggtgt cccccaatta tatccttttg tgaacaatag
     2641 cattaataaa tcctggtacg cccttcgtat cacctatagc cgtgagcttg cctttaagga
     2701 atacctggac tcccgaggag tgaggaattt tcttcccatg cgctatgaat acgtattccg
     2761 tggtgagcgt aagattcgta aattggttcc tgttgttcac aacttggttt ttgtttatgc
     2821 cactcgcagt gaggttgacg aaatgaaatc cactgtcggg gcttctcttc ctattcgtta
     2881 tatcatggac cgtgagaccc gtcagcctat taccattcct gaagtccaaa tgcgtagttt
     2941 tatcgccgtt gccggtaatt acgatgaaca ggttgtttat ctggatcctt cagtcgtttc
     3001 catgaaaaag ggagaccgtg tccgtgtcac cggtggcatc ttcgagggag ttgagggtga
     3061 gtttgtccgt atcaaaggtg accgccgtgt ggtggtttcc atccaggggg ttatggcagt
     3121 tgccacggcc ttcattcatc cctctttaat cgaattaata aagaattaaa aactctgtga
     3181 actctgtgcc ctctgtggtg catattccaa tacgtaaata aatcaccatg ttgtctttgc
     3241 aatcagaaat cgattctttg tgcgctgttt cgcacgaact tctccattta ggtctggatg
     3301 gcgaacccat ctactccgac cgtttccgtc agttgaatac ggatgtgtat catcgttgtg
     3361 agcatctttt cggttcacat ggacgtaccc tcgaagagga agcttctctt tgtatcgctt
     3421 tgttgaccgg ctataatgct accatttata atcacggtga taaggaagat aaaatccagt
     3481 cggtcctcaa tcgtagttgg gatctcttgg atacacttcc cgtctctctg ctgaaatgtc
     3541 gtttgttggt agcttgttac gccgaggtct ttgacgaaga gctggcggcg gaggcacatg
     3601 caataataga cggttggaag gatcgggaat tgacgaggga agagtttgag attgtggagc
     3661 atttaaagag tttggaagct aatccatatc cgtacagcga actacacgaa tgattcgttc
     3721 ccttctttcc cgttctcccc tttacgtttt ggctctctat gccagcgttt tgatttttct
     3781 ggtttatact tgtgcctatg cctaccgtaa gccatttacc gcagccattt atgaaggtga
     3841 gattctttgg ggattcgatg tcaaaatcct gtatgtcctt tctgagatta tcggctacgc
     3901 cctttccaag ttcatcggtg ttcgtattct gccttcgatg aaagcgggtc accgcatcta
     3961 ttatataata gggctgctta ctttttccga agttgctttg ttgggttttg cacttcttcc
     4021 agttcctttg aaggtgtgtt ctatttttct gagcggtctt cccctgggta tgatctgggg
     4081 tgtcattttt agctatatcg aagggcgtcg tatcagtgaa atattgaatg tcgggctgag
     4141 cgttgctttg atagtctctt ccggtttggt gaaaaccttg ggacaattcg tgatggataa
     4201 tttgcatgtg tcggaatatt ggatgccttt taccaccggt ttgttggtat accctgttat
     4261 gttgctttgc agctggcttc tcaatcagat tccggctccc aatgagcaag atatcataca
     4321 gcgtaccaaa cgtgctccga tggatggtaa agacaggcgt aagtttttga ggcaattctt
     4381 ttggggaatc tgcatgctgg ttgtttttta cggtgccctg accgtgttcc gtgagcttcg
     4441 tgactctttc gctgccgata tttggaagga gctccatatt gagggtgcaa tgatctttac
     4501 tcagacagag gttcccattg ccgtttttgt ccttgtactg atgttcctga ttgtgtttgt
     4561 ccgtaataac cgtttggctc ttaatatcat ttattgcatc gccgtcacag gcggttcctt
     4621 aatggttttt tccacattgc tttatgtgta cggttttctt tctcctattt ggtggatgat
     4681 tctttccggt cttggtctgt atatggggta tattcctttc acttacctga tagaacgtct
     4741 gattgcttcc cttagggtgg ttagtacagc tgtttttatt atttatttgg ccgattcttt
     4801 cggctatctg ggcactacgg gtgtgtttat ggtcaagaac ttcgtttctg ctgacatttc
     4861 ctggactgtc atgctgatgc gtactgccct tttttcagga tttgtttctg tcctgtcgat
     4921 ttttgcgatt tactgttatt tcaagcaaca attgaattca cttatattaa ttccctctga
     4981 aattcatgat taaaacagca atgatcatgg ctgccggtct tggtacccgc ttcgggcatt
     5041 ataccgagct tgtgcccaaa ggttttgtgg aggttggtgg aaaacctatg attatccgct
     5101 ctatcgaaac ccttctttcc tgcggtatcg aacgtatcat cctcggtacg ggttataaaa
     5161 aagaggctta tgaagccctt caggcggatt tcccccagat agagacctgt ttcagtcccc
     5221 gttatgccga tactaacagt atgtacactc tgtacaatac gcgtgacgtg ataggcgatg
     5281 acagtttcct gctgcttgaa tcggaccttg tttttgaacg caaggccatc ctctcgctac
     5341 tggatgacga attcccggat gtgatgcttg tctcttctct gaccaagttc caggatcagt
     5401 attatgtgga atatgaccgc aatcacatcc ttacttcctg ttcggtagac aagaacgccc
     5461 ttgaggcaaa aggcgagctg gtcggtatcc ataaactttc caatactttc taccgccgga
     5521 tgtgcgccga ttatgcgacc atcctggagt cccagcctaa actgggttac gagtacgaac
     5581 tgctccgcat gtcccgttcc gtttcccctg tccgtgtgct cagggtggag ggtcttaaat
     5641 ggtatgaaat cgatgatgaa gccgaccttt cgtatgccga ggagcacatc atccgctatt
     5701 gttaaaaaca aatcttttcc atatatgaac aagaaaatct atgtcggtat gaccgcggat
     5761 atcatgcatc cggggctgat ccatattatt catgaagcta ctaaatacgg tgatgtcatc
     5821 gtcggtctgc tgacggacaa ggccatcgcc gaacacaaac gcctccctta ccttacctat
     5881 gatcagcgta aggaggttgt tgagaatatc aagggggttt ttgaggttgt tccccaggag
     5941 gactggagct atgttccgaa tctggaaaaa ctcaagcctg actatatcat ccacggcgac
     6001 gactggaaaa cgggcccgtt gcgcgaggtg cgcgaacagg tttttgaggt gatgaacgcc
     6061 caggggggca aggtaatcga gatcccttat acccggggca tcaactcctc ctcgctcgac
     6121 aaggatatca aggcgatcgg gactacccct gacgtacgtc ttaagtccct ccgccgcctg
     6181 atccaggcca agcctgtggt ccgtatcctg gaggctcacg acggtctttg cggtctgatt
     6241 attgagaatc ttgaagtcca gaagggtgat aagcgcgagg tctttgacgg catgtggtcc
     6301 agcagcctga ccgactccac gagtaagggt aaaccggata ttgaagcggt cgaccttacc
     6361 acccgtttac aggacctgaa caatatcctt gaatgcacca ccaagcctat tatttttgat
     6421 ggagacacgg gtggcaagat cgaacacttt gtctttactg tgcgcactct ggaacgtcac
     6481 ggcatttctg cggtaatcat tgaagataaa gtcggtctga agaagaattc cctttttggt
     6541 actgacgcta tccagactca ggatagtatc gagggtttct gcgataagat cagagcaggg
     6601 aagaatgccc aggtcaccgg tgactttatg atcattgcgc gtatcgaaag ccttattgcc
     6661 ggcaaaccca tgagtgacgc cctcgaacgt gcttatgcct atgtacaggc gggtgcggac
     6721 ggcatcatga tccacagcaa ggataagtcg ggtgaggata tccgtgagtt ctgccggact
     6781 ttccgcaaag aatacgccca tgttcccatt gtcgttgttc cgacgactta tgaccatgtg
     6841 cacgaatccg aacttcacga atggggtgcc aacgtagtca tttacgccaa ccaccttctc
     6901 cgtgccgctt acccggccat gatgaacgtg gccaggacca tccttgaaaa cgagcgcgcc
     6961 gaagaggtcc gtccgctttg tatgcctatc aaggaaattc tggaattgat tccgggcact
     7021 aaataaatca gacggttatg gtaagtgtag aaaagatata cgatacgttc cttcatcacg
     7081 gtgttgactt ctttacgggt gttcccgatt cccttttgaa gaatatttgt gcctatatca
     7141 cggatcatgc tccgcgtggt aagcatatca tcgccgccaa tgaaggttcc gcggtgggca
     7201 ttgcctgcgg ttattatatg gcttctggca acgttccttt ggtttatatg cagaactccg
     7261 gtctgggaaa tacggtgaat cccctcttgt cccttgcgga cgagaaagtg tacagccttc
     7321 ctcttctttt gctggtcggc tggcgcggtg agcccggcac aaaagacgaa ccccagcata
     7381 agaagcaggg cgaggttacc cttgatcttc tgaaagccat gaaaattcct tttataattc
     7441 tggatacgga tgaagacgag gccctggcgc agatccatga cgcggttgtc tcggcgaaga
     7501 gccggtcgat tccccatgcg attgtcatcc gtaaagatac gtttggaaaa tataaattgc
     7561 gtcaggaagc cttgaatgac tatcctctgt cccgcgagga ggcgctaatg caggttgtcg
     7621 accacctcgg ggacaatgac attgtggttt ccaccacggg caagctctcc cgtgagcttt
     7681 tcgagtaccg tgaatcgaaa gggcaggggc acgcaaggga tttcctaact gtgggttcca
     7741 tgggtcacag ttcttccatt gccctgggga ttgcccttga gaagcctgac cgccgtgtct
     7801 actgtcttga cggtgacggt gcctttatca tgcacatggg tgctgtcagc aatatcggcg
     7861 atctttctcc caagaattac aggcacgtcc ttttcaacaa cggtgcccat gaatctgtcg
     7921 gcggtcaacc cacgctcggt ttccgtctgg atatcgcctc gatagcgaaa ggttgcggtt
     7981 atgcgcatgt actgactgcc tccgacaagg aagggctttc gtgtgcgctt gagaagctgt
     8041 ccggcctgtc cggcccggtt cttcttgaaa ttaaggtccg gatcgattca cgtgacgatc
     8101 tgggtcgccc tacgactact ccggtagaga ataaagagca ttttatggca tttttaaaag
     8161 atacgcattc atgaatatcg aaagaaagat ccttttgaat ccgggtcccg ccaccacgac
     8221 ggatacggtg aagctggcgc aggttgttcc cgatatctgt ccgcgtgaga aagagtttgc
     8281 gggtatgatg aaacagttac gtgacgacct ggtccgcgtt gcgcatggag acctctccaa
     8341 acatacggcc gtcctgtttt gcggctcggg tacgatcaat atcgatatct gcctgaactc
     8401 tcttcttcct gcggataaga aagttctggt tgtcaataac ggtgcctaca gcacccgtgc
     8461 ggtggaagtc tgcgaatatt acggtcttct ccatatcgat ttgaagtttt ccgtttacga
     8521 acttcccgac ctgtcggtaa tcgaaaagac gctttccgac aatccggaca tcgctttggt
     8581 ctataccacg caccatgaaa cgggtacggg tatcttgaac cccatccgtg agatcggaaa
     8641 aatagcccat tcgcacgatg ccgtttttgt tgtcgacacc acttcctccc tgggtatgat
     8701 tccttttgat atcgggaagg ataatgttga cttttgtatg gcttcggctc agaaaggcct
     8761 tcaagccatg acgggtcttt cctttatcgt aggtgatgaa tccctgatac gtgcttcaag
     8821 ggattatccg aaacgttcct actattgtaa cctctattta caatacgatt actttgagaa
     8881 gacgggtgag atgcatttta ctcctcctgt tcaaaccgtt tacgctgccc gtcaggctct
     8941 tgatgaatat tttgcagtag gtgaagaggc taaattcgcc cgtcacaaga gggtctttga
     9001 agccatccat aaaggtttgc aagagcttgg tcttcagtat gcgatcaaac gtgaatggca
     9061 gtcgggtctt gttgtttctg tattgtatcc tgatgatccc ctctgggatt ttgataaggt
     9121 tcatgattac tgctatgaac gtggctttac gatctacccg ggtaagattt ccacaacgaa
     9181 tacattccgg ctttgtgcgt tgggagagat tgatgtggag gatattgaga ggttctttga
     9241 ggtgatgaag gaggcacaat cttttgtgtg tgatgataat atttgatttt aagttttctc
     9301 ggaatagaaa tagagcctct ttttgaataa taaaaacgta ttttgatatg ataatttttt
     9361 taaatatcct atttgtatgt aattattgaa ttttagttct actaaccaat acttgattta
     9421 taaagtatac ttaatttgaa aatataagtt aatgagtttt tttagaaata aaatatttat
     9481 atttctgcaa aaaggcagtg ataggagtgt aaatataaag aagaatgtag caggttcttt
     9541 atgtcttaaa gttataaata tatttatttc tttgcaagta gttccattga ctatacatta
     9601 tgttaatcct agtaaatatg gtgtttggct aactcttagc tctattattg cttggattag
     9661 ttattttgat tttggttttg ctcatggttt tcgtaatcgt tttgctgaag caattgctaa
     9721 aggagaattt ttgttagcta ggaaatatgt aagtacaaca tatgcagtac tatttatcct
     9781 tttttctata atatgtgtga tactattggg acttaatagt tttttagact ggactcgtat
     9841 attgaagttg gaaccatcac taattttaga attaagagtg ctaatgcaga tacttatttg
     9901 tttcttttgt ttatatatag tagcaaatat atttactacg atgcttacag cttatcaaaa
     9961 accagcgtta gcatcattga taaatactgg tgggcaggta tttgctttta tagcaatata
    10021 tctgttgact aaatttacaa gtgggtcttt gataaatttg gcttttgctt tctctggtat
    10081 tccttgttta gtccttataa ttgtatctgt atttgttttt tcaacgaaaa gatatagtgc
    10141 ttttgcacca tgtattcgtt atgttaattt tagacttacc cgtaatataa taggtttagg
    10201 aggaaagttt tttataataa tgatttcaat gctattttct ttgcagttta taaatataat
    10261 aatatcgagg atacaaggtc ctgatgctgt aactcaatat aatatagctt ataagtattt
    10321 cagtattata aatatgatag cattaataat attaactcct ttttggtctg cttttacaga
    10381 tgcttatgtg aagaaagatt ttgggtggat ggctgtggtt gtgaaaaaat tggagcgact
    10441 ttggcttttg tgtattccgg ctgttgtgat tatgattata tgttcagaag ttgcatatgc
    10501 tttttggata ggtaactcag ttcatataaa tatgaagtta tctattattg tttctttata
    10561 tgtcttattc cagacattgg gtagtaccta tatgtatctt attaatggaa ctggtaaagt
    10621 aactttgcag atgatattgt atatatgttt tgcatttgtt tcaattcctt taatgagtct
    10681 atgttgtgaa aaattgggaa cgattggagc tgttgttgtt ccgtgtataa taatatttat
    10741 tcaggcaata gttggaaaga ttcagataaa tttaattgtg aaccaaaagg catatggact
    10801 ttggaataaa taattgttta tttatgtaaa atagatgtaa catgggagta atgaagttta
    10861 tcttattaaa aagcatctct tttagtgaga agtgtaataa tattttttgg aggcgtttta
    10921 atgtgttttt gtttaaacta aatggagtcg ttttaaggga tagacctgtt attagaaata
    10981 aggttttctt aaaaatgaat tcgaattcga catttgtaat agggaataaa ttccgcttta
    11041 tttcaggttc gaatttaaac ccattgtcgt caaacatagt tggttctatc tttttatctg
    11101 aaggatcaaa aataataata ggaaataatg ttggcattag ttcgtcggtt ttggtctctt
    11161 ttaaggaaat aattataggt gataatgttc ttgttggtgc tggttgttta ataatggata
    11221 caaatgggca ttctttaaat ccctttgaac gccgtatgga ggctgaaaca catgcaggaa
    11281 gaacaggaca aggaataata attgattcag atgtatggct gggaacaaat tgttcaatat
    11341 atgctggagt tcatattgga agaggtgcag ttgttgcagg aaatagtgtt attcgtaatg
    11401 atataccacc ttatgctgtt gttttaggta atcctgctaa aatcatttct tttgtttttt
    11461 caccagagga gatagttgag ttagagaaaa aaaattatcc gaaagatgaa cgtataccat
    11521 tagaagtttt agaaaaaaat tataataaat attatataaa taggtttaag gagataaagc
    11581 agtttttaaa actatgatta tattcaaact atacaactat ggaattgaaa gaatttgtgg
    11641 ctcagtttgc tgagcaattt gatgaaacgg aaatatcaga aattcaatct gatacagtat
    11701 ataaagagtt ggatgaatgg agctcattaa catcgatgag tattattgcc ttcgttaaga
    11761 cagtgattgg gaaaaacgta acaatgactg actttaaaaa tgctgaaact gtagaggact
    11821 tatacaatgt tattctatca aaaaaataag atgaaagaag ttaatccgtt ttcactgtta
    11881 ggtaaaaaaa tacttgttac tggagcttct tcaggtatag gtaagtctat agctattgcg
    11941 tgtgcaggaa tgggagcgaa cctatacata acagctcgca gcaagaaaaa gctcaatatt
    12001 actcttgaag agatgttgga agaaggcgag cacaaagcta ttattgctga tctcacgaaa
    12061 caggaagata tagaacgtct ttgtcaatca cttccaaagc ttgatggtat tgtacattgc
    12121 gctggagtgg gaagtagagt attatgtaaa aatctcacag aggcagatct taaagaagtg
    12181 tttcttccta atgtagaagc tcctatttta ctgcaatcgt ctttgctttc acggaaaaag
    12241 ataaataaag aagcaagtat tgtattcata gcttccagag cagcgagaat tcccagtatg
    12301 ggtaatgctg cttatagtgc aacaaaagga gcaattctga gctatgcaag atgtttggcc
    12361 ttagaacttg caccacaact gattcgcgta aactctgttt gtcctgcaat gatttggaca
    12421 gacttgattt tacaagaggg tgtggaaaga gaaactcttg aggaggctga aaagaaatat
    12481 cctctaaaaa gatatgggta tccaaaggat gtagcttacc ttgtactcta tttactttcc
    12541 gatgcttcaa gttggatgac agggtcggct gttgatttaa cgggaggagc gatagaactc
    12601 taatattata gtataattat gatttatatt aaagcagtta gtttatatct tccaaaaaag
    12661 gtaataacga atgaagatct tgtacgtgaa tttcctgagt ggagtgtgga gaaggttgca
    12721 aagaaagtag gtgtaaactc tcggcatgta gcagaggaaa atgaaacagc aggtgatatg
    12781 gcagaaaaag cagctcttcg cctttttaaa gaatatgata tagaaccaaa atcaatagac
    12841 tttattttac tctgtacaca gagtcctgat tacgttttac cttcaactgc ctgcatcctc
    12901 caacatcgtt tggggatacc gacaacagcg ggagcttttg attataacct tggttgttct
    12961 ggctgtattt atggccttgc tctggcgaag gggttaattg ctggagggat agctaagaat
    13021 gtacttatac ttacggccga aacatatagc aaatatctgc attcaagtga taaaagttat
    13081 cgctcaatct ttggtgatgg agcagcagcc tgccttgtaa gtactgaagg ttttgcagaa
    13141 ataggtaatt tttcattggg tacagatgga agcggggcgg agaaactaat tgtaaagact
    13201 ggaggagcac gccataagaa cataacaggt ttttctacta ttgatgatga gggacatata
    13261 tgttttgatg attatttata tatggatgga ggtggcatat tcaattttac cctcgatgct
    13321 gttcctgcta tgatgaaaga tattttgagt aaaaatgaca tggaaaagaa tgatgttgac
    13381 tattttgtat ttcatcaagc aaataaattt atgctcaata caattcgtaa ggtatgtgtt
    13441 ttgccaaaag aaaaatttta tgtaaatcta tatgaaacag gtaatactgt ttcttctacc
    13501 gtcatgatag gactaaagga ttgtataaat gctggtgaaa taaaggaagg tatgaaagta
    13561 atgatagcag gctttggtgt cggattgagt tggggagggg taattctaaa attttaaaga
    13621 ttctctttat taggtaacaa ataataaaat aataatttat ggacaaacca ttgatttctg
    13681 ttatcacaat aaactacaat aacagaagtg gcttggaacg cactattaaa tctgtaatta
    13741 atcaagtatc aacagatttt gagtacctcg ttattgatgg acactcagaa gatggtagtg
    13801 tggatattat ttgtgaatac gctgatcaag tagatttttg gctgtcagag tcagatacag
    13861 gtatctataa tgctatgaat aaaggtgtag caaatgctca tggtaaatat gtgctttttt
    13921 taaattctgg agatatgttt tataataatc ttgttttaaa aatggtgcat gataaattaa
    13981 taggtattaa cgctgattat gttgtagggg atatcgttat taagtataga catcattttg
    14041 atagaataat acgatcacct cgaaacgtaa cagctgattt aatcattgta gatgcgttat
    14101 ctcatcctgc aagctttatt aagagagaca ggttgttggc ttgtccttat gatgaaaagt
    14161 tgaaaattgt ggctgattgg aaacagtctt ttcaagatat aatagaaaat aatgcaactt
    14221 atgaaaaatt ggatataata atagctaagt ttgaacctgg gggtgtatct agtacaaatc
    14281 gtgcac
//
