LOCUS       gnlProkkaENAJNLPB_135  11655 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ENAJNLPB_135.
ACCESSION   gnlProkkaENAJNLPB_135
VERSION     gnlProkkaENAJNLPB_135
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 06:43:58
            Original ID  :: gnl|Prokka|ENAJNLPB_135
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11655
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1119
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 43.8;
                     E-value: 2.3e-13)"
                     /gene_kind="transport"
                     /locus_tag="ctg135_1"
                     /transl_table=11
                     /translation="MAVLYRQREDLTSEVVQIDIKSIMDGTSPNLALMKNDILYIPSIH
                     DLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEAASTVRIDISRRIKNPRST
                     ADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPGYQAQQNVAIEGEILFGGN
                     YAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKKRMGDVIRLMSRQLGEAMI
                     DSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMVPNTV
                     SYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKA
                     KKKGNIANILGYATSFSSLGMMIASIANLIKK"
     protocluster    1..11655
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2341:6655]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2342..6655
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11655
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11655
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             1130..2278
                     /locus_tag="ctg135_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             2342..3061
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.8e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             3082..4383
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.1e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.2e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.5e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             4400..5524
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             5534..6655
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg135_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.7e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        5624..6631
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg135_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg135_6_Aminotran_5.1"
                     /locus_tag="ctg135_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             6652..6795
                     /locus_tag="ctg135_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             6998..8482
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg135_8"
                     /sec_met_domain="Polysacc_synt (E-value: 1.5e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             8436..9695
                     /locus_tag="ctg135_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             9704..10453
                     /locus_tag="ctg135_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             10453..11493
                     /locus_tag="ctg135_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 cgtgccgtcc tctatcgcca gcgtgaagac ctgaccagtg aagttgttca gatagacatt
       61 aagtctatca tggacggcac ttccccaaac cttgccctaa tgaagaatga catcctctac
      121 attccaagta tccatgacct ggaagaccgg ggtaatgtca cagttcacgg tgaggttgcc
      181 caccctgatt cctatcctta tgcggataac atgacacttg aggatctgat cattcaggcc
      241 ggtggcttga aagaagccgc ctctactgtc cgtattgata tatcgagacg aatcaagaat
      301 cctcgtagta ctgcggataa tgatacgatt ggtcagatgt ataccttctc tttaaaggat
      361 ggttttgtaa tagatggtca gcccggtttt atccttgagc cttatgatca ggtttatgtc
      421 cgtcgcagtc cgggctatca ggcacaacag aatgtagcca ttgaaggtga aatccttttc
      481 ggaggaaatt acgccatgac cagccgtgag gaacgtcttt ccgatttagt gaataaagcc
      541 ggcggtccga ccaattatgc ctatctgcgt ggtgcgaaac tgacccgtgt ggctaacgct
      601 agtgaaaaga aacgtatggg tgatgtaatt cgccttatga gcaggcaatt gggcgaagcc
      661 atgattgact ctttgggtat tcgtgttgaa gatactttta cggttggaat agatttggaa
      721 aaagccttga gcaatcctaa aagtaatgcc gatcttgtct tacgtgaagg tgatgtgatc
      781 tccataccta agaatactaa tactgtaact atcaatggtg ctgtcatggt tccgaatacg
      841 gtttcttata tgaagggaaa gaatgtggat tattacctga atcaggccgg tggctgttct
      901 gataatgcaa ggaagagtaa gaagttcatt gtttacatga atggtcaggt gacgaaggtt
      961 aagggtagtg gtaagaaaca gattgagccg gggtgtgaga ttattgtgcc tggtaaggct
     1021 aagaagaaag ggaacatagc taatatttta ggttatgcta cttccttcag ttctttggga
     1081 atgatgattg cttctattgc taatttgata aagaaataaa tgacctatta tgattgaaaa
     1141 gcaatcttat caagaaccgt tttctgaagt ggataaaagg aaagatgatg aaatggaaat
     1201 agacttgatg gctatttttt ataagattat tactgttcgt ggagtactat gcaaagctgc
     1261 tggagtggga gtaataattg ctatagtggt ggcattgagc attcccaagc aatatacagt
     1321 aaaggttacc ctttctcctg aaatgggtaa tgcgaaggga agtaatggtt tagccggact
     1381 tgctgcctcg tttttgggag atggggctct aataggggaa agcacagatg ccttgaacgc
     1441 ttctctttca gcagatattg tttcttcaac tcctttttta ttggaacttt tagaaatgga
     1501 agtctccgtt tctaaaaagg atgataaaat gactttgggg tcttatctcg atgaagagtc
     1561 atctccttgg tgggattatc ttataggttt tccgggcata gtaataggag gagttaaatc
     1621 attattcgga gaagatacgg ttcctgccag tggagggcgg caaggaacta tcgaattgac
     1681 gaaagaagta aatgagaaga ttaattttct taaaaagaag attagtgcat ccattgataa
     1741 gaaaaccgcc ataacgagca ttacggtcac cttacaaaat ccgcagatca ctgcggttat
     1801 agcagattct gtcgttcata aattacagga atatattatt gggtatcgaa cttcaaaagt
     1861 aaaagaagac tgtgcgtatt tggaacggtt gtttaaagaa cgtcagcagg aatattatgc
     1921 tgctcaaaga aaatatgcgg attatgtaga cgcccatgat aatgtggttc ttcaaagtgt
     1981 acgtgctgag caggagcgtt tacagaacga catgagtttg gcttatcaga tatatagtca
     2041 ggttgctaat cagttgcagg tatccagagc caaagtacag gaggaaaagc cagtctttgc
     2101 agtagttgag cctgccgttg tacctttgaa accttcaggt atgggactca aaatttatat
     2161 tttattattt gtgttcctgt ccgtatctgg tactctcgtg tgggtgtttt ttggcaaaag
     2221 tctgctggct agcttgagaa aagaactgaa aaataaggag atagaacagg ataaatgatg
     2281 ctaaaacgtc gtttacaaca ttcttacatc aattaaattc acttactata ttattaaacg
     2341 aatgatacgt acagctatga taatggctgc gggcatggga acccgttttg gccaatatac
     2401 agaattgata cctaaagggt tcgtcaaagt gggaggtatt ccaatgatag ttcgttctat
     2461 tgatactttg ttatcatgtg acattgagcg aattgtaatc ggtacaggat ataaacaaga
     2521 agtttatgaa gaattgaaga cagactatcc tatgcttgaa acctgtttta gtcctcgtta
     2581 tgctgaaaca aatagtatgt atactttata taatacgcgg gagattctgg gcaatgatga
     2641 ttttttattg ttagagtcag atttgatttt tgagaaacaa gcaataatga gcttattgga
     2701 gtgtcctgcg gcagatgcaa tgctaataac tccagtgaca aagtttcaag atcagtatta
     2761 tgtggaacat gatgataatt ttcgcctttc ttcatgttct gtcaataaga ataaactaaa
     2821 cgctaaaggc gaattggtcg gcatccataa actatccggt tccttttaca aaataatgtg
     2881 tgctgattat gcgagtattg ttgatgaaca acccaatttg ggatatgagt atgaattact
     2941 acgaatatct tgttctcaat ctcctgttta tgtgcataaa gtagaagggc tgaaatggta
     3001 tgaaatcgat gacatatcag atttggaata tgcagagaaa tatattgttc cgtattgtta
     3061 attaaaataa tatatcaaat tatgagtaag acagtttata ttgggatgac tgcggatatt
     3121 atgcatccag gacttatccg cattattaat gaggctacta aatacggtga tgttataatt
     3181 ggtcttctta cagataaagc tattgcggag cataaacgcc ttccttatct gacctatgaa
     3241 caacgaaaag aggtagttca gaatattaaa ggcgtatgta aagttgttcc tcaagaagaa
     3301 tggagctatg ttgagaatct caaacgcatt aaacctgact atataattca tggtgacgac
     3361 tggaaaaccg ggcctttacg tgaagaacgt gtgcgcgtat ttgaagtgat gaatgaacag
     3421 ggaggaaagg ttatcgaaat tccatatact ttgggaatta attcatcttc tttggataaa
     3481 gatattaagg ctataggtac aacccctgat gtacgtttaa aatcacttcg tcgtttgata
     3541 aatgccaaac ccgtagttcg tattttggaa gctcatgatg gactatgtgg cttgataatt
     3601 gaaaatcagg aaatattaaa aggggataag agggaagtat ttgacggaat gtggtctagt
     3661 agccttacgg attcaaccag taaaggtaaa cctgatattg aggcggttga tttaactacc
     3721 cgattgcaag atttgaataa tattctggag tgtactacta aacctattat ttttgatgga
     3781 gatacaggtg gtaaaattga acatttcgta tttacagtac gcactttaga acgtcatgga
     3841 atttcagcta taataattga agataaagtt ggattaaaaa agaattcatt gtttggtaca
     3901 gatgttattc aaactcaaga tacaatcgaa ggtttctgta ataagatcaa agcaggaaag
     3961 gcatctcaga ttactgatga ttttatgatt atcgctcgta ttgagagcct tatagcggga
     4021 aagccggtaa gtgatgcttt agagagagct tttgcatatg tccaagcggg agcggacggt
     4081 attatgatac atagcaaaaa taagtcgggt gaagatataa aagaattttg tttggcgttt
     4141 cgaaaacagt atgctcatgt acctatcgtg gttgtgccta ctacatatga tcatatttat
     4201 gagtctgaat tgtgtgattg gggtgtgaat ataattattt atgctaatca tatgcttcgt
     4261 gccgcttatc ctgctatgat gaatgtcgca aagataatat tagagaatga acgtgcttta
     4321 gaggtgcgcg aactgtgtat gcccataaaa gaaatattgg aactgattcc aggtactaaa
     4381 taaaaagagg aatatcatta tgttaagcgt agaaaaagtt tatgaaacgt ttctgagtca
     4441 tgacgttgat ttttttacag gagttccaga ctcattacta aaaaatattt gtgcctatat
     4501 cacagaccat acttcacgtg agaaacatat catagctgct aatgaaggtg cggctgtagg
     4561 aattgcttca ggttattata tggcatcagg taaggttcct gtggtttata tgcaaaattc
     4621 cggcttgggt aatactgtta atcctctgct gtctcttgca gatgaacaag tatacagttt
     4681 tccaatgctt ttgatgattg gctggcgtgg tgaaccggga acaaaagatg aacctcagca
     4741 taaaaaacag ggtgaggtaa ctttagattt gttgaaagca atgcggattc cttatataat
     4801 tcttgattca aatgagaatg atgcatttat tcagctccat gatatcatac aatcagcaaa
     4861 aactaagaat attcctcatg caataattat tcggaaagat gtttttggca aatataaact
     4921 tcaaaaagag ttcggatgta attatccttt atctcgtgag gatgctttgc aaatagttgt
     4981 ggattatctg cctgaaaatt cagtggtcgt ttctactact ggcaagcttt ctcgtgagtt
     5041 atttgaatat cgagaaatga aagagcaagg tcatgaacat gattttctca cggtaggctc
     5101 tatgggacat agttcatcaa tctctttggg tattgctata gcaaagcaag atagacctgt
     5161 ttattgcttg gatggtgatg gagcatttat tatgcattta ggggcaatta gtaacattgg
     5221 cgatttatct cctaaaaact attatcatat tttgtttaac aatggtgctc acgagtctgt
     5281 aggaggacag cctactttag gatttagttt agatattccg gctattgtcc gggggagcgg
     5341 atataagcat acttatactg tttgtacaaa agttgaaatt gaagaagcaa tgaagcagct
     5401 tccaaagtta tgtggtcctg ttttgttgga aataaaggtt aaaatagatt ctcgggagaa
     5461 tttgggacgt cccacgacta ctcctataga gaataaggag cattttatgg attttttaaa
     5521 ataaatatat tcgatgaaaa tagaaagaaa aatattatta aatcctgggc ctgccactac
     5581 tactgacagt gtaaaaatgg cacaagttgt tccggatatt tgtcctcgcg agaaagaatt
     5641 cgcaggtatg atgaaacaac ttcgggacga tttggtcaga gttgctcatg ggaatttgga
     5701 aaaacatacc gctgtattat tttgtggctc aggaaccatc aatattgata tatgtctaaa
     5761 ttctcttctt cctgaagaca aaagggtgct tatagtgaat aatggggcat atagtacccg
     5821 tgctgtagaa gtgtgtcaat attatggttt gcctcatatt aatttggaat tttccgttta
     5881 cgaacgtcct gatttatcgg tggtggaaaa tgtgttgcaa gaaaatcctg atatagctat
     5941 ggtttatact actcatcacg agacgggtac aggaattctg aaccctattc gcgagatggg
     6001 cgctatagct cataaatatc aggctaaatt tgtcgtcgat actacttctt ctttgggcat
     6061 gattcctttt gatatagaga aagataatgt ggatttttgt atggcatctg ctcaaaaagg
     6121 acttcaagcg atgacaggtc tttcttttat tataggcaat gaggaacaga ttaagttttc
     6181 aaaaaaatat cccaagcgtt cttactattg taatctttat ttgcagtatg agaattttga
     6241 gagaacaggt gaaatgcatt ttactccacc ggtacaaact atttacgcca ctcgtcaggc
     6301 attaaatgaa tattttgaag tgggtgaaga agctaagttt gcccgtcaca aaagagtttt
     6361 tgaggctatt cattcaggta taaatgaaat tggtcttaaa agtgtaataa agcgtgaatg
     6421 gcagtcagga ctggttgtct cagttcaata cccagaagat cccaactggg attttgagaa
     6481 aatacatgat tattgttatg agcgtggatt tacgatttat ccaggtaaga tatcaactga
     6541 ggatactttt agaatctgtg ctttaggaga gatagaagta gatgatattg agaacttctt
     6601 taaagtacta aaagctgcat taaatcatta taacgtcaca ttaccgatgt catgattgca
     6661 gaaatattat tgaagattcg tcatttttat ttttcccttc gtggtataca cttccatccg
     6721 gaaagtgtta tttctggagt gcctattcgt agctttcgct tagtaggcaa atatggcaat
     6781 attaatttga ggtgatgcat taggagttct ttattcttat aaaaaggcat cggtagttat
     6841 aggagataat gtttgtgtag ggtaatttgc ttttagtggg agagaccata ttagaattgc
     6901 ggtaaggggc gaagaagata ataaccaatt agtgagaata ttggaaaaat ataattgata
     6961 tcggtaaatg tagttgtttt tatactgtat ttaagtaatg gaaaatctaa agcagaaaac
     7021 tgtatcagga ataatgtgga gcgctataga acgtttctct ttacaaggag tacagtttat
     7081 aattcaaata atattagctc gtttgttact accatcggat tatggtatga tcgggatgtt
     7141 agctattttt cttcaagtcg ctcaagtatt tatagatagc ggttttacaa atgctttaat
     7201 ccagaaaaaa gatagaactg aagaggattt tgccactgtc ttttatttta atattcttgt
     7261 cgcagtatta ttctatggta tattgttttt ttcggcttct ttgattgcag acttttataa
     7321 tatgccgact ttagttcttg taattcgttt tatagcattg tcgttgataa taaatgcttt
     7381 atcggctatt cacagaacga aattaattat ttctgtaaac tttaaaactc aatctaaaat
     7441 ttcattaggt gcagctttta tatcaggcgt gattggaata tggatggctt atgtcggttg
     7501 cggggtttgg gctttagttt ggcaaactct cttaaatagt ataattttga caattttgtt
     7561 ttactgttta gttcattgga aacctttaca tactttctcc aaaagttctt ttgaaagatt
     7621 attcaatttc ggatctaaat tattgatctc aagtcttatc aatacagtat atcgtaatct
     7681 gtataccatt gtaataggaa aaaagttttc tgttgtagag cttggttact atacaagagc
     7741 agaacaattt gctatttttc cttccaataa tttaaatgct ttagtttcta gagtagcgta
     7801 tcctatttta agttccattc aagatgatga taaatgttta acaaacgcat atcgaaatta
     7861 tatcagatta tcctcatata taatttttcc tttaatggta ggtttacttg ttttggctaa
     7921 tcctattatt agtctattgt taacagataa atggtctggg gttgttattc ttttacagat
     7981 attatgtttg gattggatgt ttgatcattt gagccaaatt aatttgaatt tattatgggt
     8041 taaaggaaga tctgatctgt cgttacgtct tgaaataata aaaaagacga ttgctatatt
     8101 cattcttttt gtgtcaattc catttgggct tgaggtgatg tgttggggta gagttattta
     8161 ctctctgata gcgacatatt tgaatacata ttatactaat tctcttattg atttgacctt
     8221 aaagttgcaa gttaaagatg tatttccaag tttaatactc tctttcataa tgggggggat
     8281 cgtttttata tgtatttctt tctttgaaac tgatatagta aaaattgtga ttggatgtat
     8341 tactgggatg tccttctata ttttactttc ttttcttttt aagctagatt cttttttttg
     8401 tattttaaca ttgatcatta aaactaaaaa catagatgaa aatattaaaa aagatttttc
     8461 aagtaatagt aaagataatt aaccattgtg tgccagttga tagtagatca ttgtatttta
     8521 ttcctcatcc taattgtaga acagataaat atgatattat aaattattcg tcagataatg
     8581 ttctcgttct gttaaattat ttgctaaaaa aagatagtgc tgaatattat aaaatatatg
     8641 ttgaaattta tgattcttct cgtatttcag aatatcaaga atatatttat ggcataaatc
     8701 ctaatattag gtgtactttt ttatgtgcat gtgttggacg ttttttcttt aataaagtat
     8761 cttttaagga tatgttgtat gccttttttt gtttttgtag agcaagtaaa tgttttacag
     8821 ctacttttta ttatgatttt tcatttaaaa aacgctctca acagattatt tgtttggggt
     8881 attatactcc attcaaagat gattatcata tgggagatca ttcttatgat aaatttcgta
     8941 atacaacatg taactcattt gattactcta ttgctacttc ttgtttaagt gctagaataa
     9001 tttcaataga ttgtggaatc tcatatgata aattcaaagt cttaggattt cccagaaatg
     9061 atttgttgat atcgaaaaat aattgcaatg ttattaaaag agaaatttcg aaatttgcgg
     9121 gatatgatgt aactaaatat atagtttata ctccaacttt tcgtgattat gagactgtta
     9181 ctgaaggtaa tttgcgttca atactcggat atgttgattg tgatttgttg aagttatcga
     9241 aaatactatt gaagtttaat gcggctttaa ttcttaaatt acatcctttg cagaataaaa
     9301 cagtcttaaa aaaagattta cccaaaggta tacttgtttt tgaacaaaca tataaatatg
     9361 gattgtatga tcttttgtca ttttcagatg gaatgattac tgattatact tctacctatt
     9421 ttgatttttt attggtaaat aagccagtca tatttaattt ctacgatatt gaagaatatc
     9481 gtagagtaag aggtttctca tttgagccaa tagaattttt ttgtgcaggt gatattgttt
     9541 acaattataa tgaattgata gatgctgtga tgggacttct ggctgggaaa gatattcatg
     9601 ctgaacatcg acgtcatatt tctttattga tgaatcaatt tcaagatgat aattcaacaa
     9661 agagaatatg tgacatattt ttaaatgaaa tataataaat aaaatgaatt atgcatttgt
     9721 ggtgcaggca cgtttaggtt ctacacgttt gcctggaaaa atattgaaac ctttctatgg
     9781 taatcaatcg attcttgact taatggttca taagctttct gctatatcga atattccagt
     9841 aattattgct acaacaaatt ctgttatcaa tgaacctatt gaaaagaagg cacttgcatt
     9901 aggggtaaag tgcttcagag gtgaggagaa tgatgtttta aaacgattca ttgatgttgc
     9961 tgaatatttt gatatacagg gtatattccg aatatgttct gataatccat ttttagatgt
    10021 acatgcggca aggcaattgg tcgaaatagc aatgaaatct tgtaacgatt atataagttt
    10081 tgatattgat ggtactccat caattaaaac tcatttcggt ttttggggag aatttgtaac
    10141 gcttgatgcg ctgaagcgag ttataggatt tactgatgat ttattgtatc gtgaacatgt
    10201 tactaattat atatatagtc atcctgaact ttttaatatt caatggattt caggatctcc
    10261 agtcgtgtca aaacatcata atattcgact cacgattgat acgttagaag atttttctgt
    10321 agcacagaga atatataggg atttacaaga aaaaagagtg gaaatatcga tagaagtgat
    10381 tgtagactat gttcgaagac atgcagaata cattcaactg atgaaacaac aaataaaaaa
    10441 aaattctaaa taatgaagaa tacttatatt attggtgaaa tagggcagaa tcataatggt
    10501 tctgttgact tggctaagtt gattattgaa ttaatctcac gacctgtaca tgaggatgtt
    10561 tttggtatgg atttcatgcc aatgaatgct gttaaaatga ctaaaagaga tttatcagaa
    10621 gaattggctg tttctcaaat gaatcaaata tatgacaatc ctaattcttt tgggcgtact
    10681 tatggtgaac atcgtgcttt tcttgagctt gatgatcaag cgcattttga gatttataaa
    10741 tatgctaagt cattaggatt agattttatc gagacgttat gtgccaaagg atgtctgtct
    10801 ttgcttaaac tgttcacacc ggataggcta aaagttgcta gtcgtgattt gactaactta
    10861 ccattgcttg aagcattagc agaaactcat attcctatta tattatcgac aggaatggct
    10921 ggtcaaagag aacttgacaa tgcattagat gtgataacga gatatcatag taatatagct
    10981 attctacatt gtgtatctca gtatccaact catccaaata atttgaatct acgtacaata
    11041 acatatttga agaagcatta caataagttt gagataggtt tttctgatca tacaataggt
    11101 atttctgctg ctacagctgc tgtagcgatg ggagcggaaa ttatagaaaa gcatgtaaca
    11161 attgatcggc atatgaaagg aacagaccag cttggctctt taggtccaga tggggttaat
    11221 cgtatgattc gagatattcg catagcagag tgttggcttg gtactgaaga tctttatata
    11281 gaaaaagggg tggagaagtc taagataaaa cttgaacgtt ctattgccac tcgaaaatat
    11341 attccagcag gtagtattat tcaagagtcg gacattcatt tactgagtcc tggtgatggt
    11401 tataaatgga tagataaaaa aaatgtaatt ggtcattttg ctaaacaaga tatatcagcg
    11461 aatgaaataa tatatcctga ttttattgaa tagatatatt cctactgcaa cttgtattac
    11521 ggtatagagt actgcctgct ataagctaag tagtgattaa taaataaggg taaaatacta
    11581 aaaaaatgaa agagataaag cttatactta cagatattga tggcgtttgg actgatggcg
    11641 gaatgtttta tgatc
//
