LOCUS       gnlProkkaCONNBLJC_9    14470 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CONNBLJC_9.
ACCESSION   gnlProkkaCONNBLJC_9
VERSION     gnlProkkaCONNBLJC_9
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 06:29:05
            Original ID  :: gnl|Prokka|CONNBLJC_9
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14470
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14470
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3682:4470]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3683..4470
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14470
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14470
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             94..1197
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_1"
                     /sec_met_domain="PF04055 (E-value: 4.5e-30, bitscore: 97.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESLQDINPVERALVNKATANRTPINATIELTPTCNFRCDMCYIR
                     MEKSQAEKRGGLRSIEEWLHIADQLQEIGTLFILLTGGEPLLYPDFKELYIRLKEKGFI
                     LTINTNATLIDDETVRLFQRLKPRRVNVSLYGVTNGTYLNLCHATNGFDRCLEGLKRLK
                     EYGIDTKLNLTLTRQNIKEHRQMLELADEWDLPMLTNSYISVYSRPGCATTLPLDTCRP
                     VPDEVAHAEVEALEHKYGKEYTSYATHVLQQLERGESPVPAEGIGLACRAGKSSAWINW
                     QGVMTPCVDMETPAVSLLSTTVSDAWKQIVTKCEQLPFHKECAGCTLRSICDVCYANAR
                     NEKGQCGGIGYLCRIAKSKKKQMKGSL"
     CDS             1233..2339
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_2"
                     /sec_met_domain="PF04055 (E-value: 6.1e-24, bitscore: 77.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDHLHDANLLERALVDKANQSRVPITTNFELTPTCTLNCDMCFIR
                     TERSVVERHGGLSPLQQWLDWAEQLQDMGTLFILLTGGEPMLYPHFKELYTRLREMGFI
                     LTLNTNGTLIDNEMVRILQTHKPRRINVTLYGDSRETYGRLCHNPQGYTLCMEALKRLK
                     KADIDVKLNVSIVRKNEKDYDEIIRLAQHLDIPAEVNSYMFPLSRPECGSLRNILTERL
                     DADEAARIEMQYMEYKKGNDMARYMHDLKYTLAHVEGTRACSLECRAAKSSCWINWQGI
                     LTPCVMLDQPAVDLKKIPMTTAWQQLLEEAKELVSHTECEGCHLRPVCNVCYAAAHCEK
                     TITGSMDYLCQMAKAKERIITNYPPVIH"
     CDS             2352..3227
                     /locus_tag="ctg9_3"
                     /transl_table=11
                     /translation="MRLNIGPLTIELSGVTEQEIPVNSRLFLDHKPATKEADRYYTFYF
                     VNRLPLPSNDWQITFQRNDIVVFRKEEQETRLLAVGNLNACYALYQERNERDANIYFIE
                     GLKRELQTDTLFISCLCLERPLSVQGCYILHCTFLDYRGQAILFSGPSGIGKSTHANLW
                     CRHIPGTQVLNGDRALLCPLPNGDYEITGWPVCGSSGICHNERRPLEAIVFIEQASDNT
                     IRPQTAMKHFKALCSQVTINWWNPKLTGKALDDLQVLTRQTSISTYACNMNPEAAFTLH
                     RYLTKLEIIR"
     CDS             3246..3686
                     /locus_tag="ctg9_4"
                     /transl_table=11
                     /translation="MKTVDTKEYISMLRTLIEEGKQVSMIISGSSMAPFLIHARDHIYL
                     KSPSGELRKGDMVFYQRSNGEYVMHRIYNVKNEEYYLIGDAQTVIEGPIQREQIFAIII
                     KVKRKGKWIVPEDFQWKFFAHIWPNIIPLRRTIIKTYRFFKR"
     CDS             3683..3964
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_5"
                     /sec_met_domain="PF05402 (E-value: 1.1e-16, bitscore: 53.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 4e-14,
                     bitscore: 45.1, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRTKEFIKRNIAGEIVLVPSGQTAREFNGMVTLTETGEFIWEHI
                     EEAESFNHLVLLILEEYEVDKDTASQDAAGFIMQLLQAGMIRPTGINW"
     CDS             4201..4470
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_6"
                     /sec_met_domain="PF05402 (E-value: 3.5e-17, bitscore: 55.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.7e-09,
                     bitscore: 30.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLNSNLILRQVGGEYMIVNPFSETMDMAQVYSLNETAAWLWKQL
                     ENKEFTVDEAGALLCNEYEVNKDTARNDANELCRQWLETGLAIE"
     CDS             4510..5562
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_7"
                     /sec_met_domain="NTP_transf_5 (E-value: 3.1e-34, bitscore:
                     111.1, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLLRQGLWDRQEDCSALFPLDEKEWNEIHSMARKQTVQGIIYDG
                     IRLLPTEAVPPRKVLLGWMVEVDTLERVNRQHRETIKALQQIYVQSPSIPFLLLKGIGT
                     ADFYPHPEHRIAGDIDLWFGNKTQTEQANQRMEKLGLPVKRGTNGEASCLINRVLIEHH
                     SRLIELHNPFLQKEIRQWEAGVFTNSQGKLPSEANHLLLSTHILKHLINEGIGLRQLCD
                     IAMAFNALHSVTNKNELECICRKWHIHRWNRLLYALLIKYLGVPADLLPFSTSLCPDKL
                     MQEIWESGNFGHGDERYGERPTGKWANKRYTLKRIFHKMHLSLGYAFDETFWWLAGLAL
                     LRFKEMIKKK"
     CDS             5559..7247
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 221; E-value: 4.9e-67)"
                     /gene_kind="transport"
                     /locus_tag="ctg9_8"
                     /transl_table=11
                     /translation="MKELLKKFLQKLTRENLSNTCQLGWKAFKWVMQVTEGYHWLITFS
                     IFSGIFGVVMSLVNVAMSKWIIDVATGAQEGNIYLVATIVALSFLLGMGIKLVSPWIFG
                     KINMRISIRMQNSLSDALMMCSWKGAGKWHTGDLLTRISSDASEVLGMGMGILPNLLVT
                     GLQLASSFIYLWILDARLAWFILGVTPLVLLSKIYFRKVRELSCAQKKMNSEMGTVMQE
                     NLSKRILVRSLGATNYRKQKLHETQEKLFKLGMEQIKFSTFTQGVMGFTFGGGYLCAFL
                     WGIFQLHNHEITFGTMTAFLQLVGQVQGPFLGLISIPPSLIRGWTSVERLMALFEDVEP
                     DEHPVYIDQPLTLNFRKVSFGYEEGQPVLDRFTAAFHPGSSTAIAGPTGTGKTTIIRLI
                     LALVYPEKGRIDLTTDDGRTLSVTPDLRINFVYVPQGNTLLSGTIRENLWLGSPGADEE
                     ALHKVIRLACAEFVFSLPEGLDTKIGEHGYGLSEGQAQRIAIARALLRPGRIWLFDEAS
                     SALDTETTTHLMDNLLQWGKNNTLIFVTHDSRLMERCDQVIHIKE"
     CDS             7269..8078
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 72.7;
                     E-value: 3.7e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg9_9"
                     /sec_met_domain="Poly_export (E-value: 3e-13, bitscore:
                     42.2, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTIKLACLLAIIIFSSCASRKDFVYLQDMDELQEYPMVQKYEA
                     IIHRDDRLSIIVNSKNPELSLPFNMSGSRSYSVEADGSISNNEVGVLSDEKEKGYLVDI
                     NGNIDFPVLGQLHVEGLTRRQLTELIKKRLINEELLKDPMVTVNFLNFKFSVLGEVGHV
                     GTFEVKGDRITLLEALAMAGDLTPRSRLDRIAVIREYGNKRRILFHDIRSKDIFTSPYY
                     YLQQNDIVYVEPTNMKATEQAQRKLSTWSMILSFITTITSLVLLTTK"
     CDS             8091..10502
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216:exopolysaccharide biosynthesis domain protein
                     (Score: 282.5; E-value: 1e-85)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_10"
                     /transl_table=11
                     /translation="MIRMSEQKDMSGDKTLSGGGFNINPVDIIMYLLSKWYWFVLSVSL
                     FGGYAWYQYAKLPFIYSRSATVMIKDAYSNNIGRGLDRFNTYSYTNVSNEILQFQSHKL
                     MRDVVNRLHANVCYLIMDDLREEELYTQAPVKVSFPEEEDHLDFSLTVRILNRKQVRLS
                     DFSTDATSITLTANLGDTIQSPVGKIVVSPTLYYTDKWFNTPITIRRQSTDTMASLFRS
                     NLNISQAENDASILYLSLRDYSTARAEDVLNMLITVYNEETIKDKNQIAINTSSFINER
                     LVIIEKELGGVENELQSYKQNNDIIDIGSAASMSMSDKRQYSSTTQELELQARMARYIK
                     SYLVDPSKETELIPSNTGIADINIETQITAYNANKLKRDKLIEGSSDKNPIVQELNKNL
                     IAMRQNIIRAIDNMIVSIDVKLNEARSRAGEAQWRVTNIPRQQQQMLSIERQQRIKEEL
                     YLYLLNKREENALSQATTETDARVLDPAGGGDAPISPNGRSMIMAGVIKGIALPAIVLL
                     LFLFFDTRIRNRKDIEDAVTVPFLGEIPKDSSKGKTENKETAHGIAVRAQGRDIVSEAF
                     RIIRTNMDFMRVKSKNMQVVTFSSFGPGAGKTYVSSNLAASFAQTDKKVILIDMDIRKG
                     TLTSHTRLHTKEKGMTSFLAGKATTDEIIKHNEICENLDFIPAGPIAPNPSELLLSEQL
                     EVLITELRNRYDYIFVDNVPVGVVADAAITNRIADLTIFVVRVGKLDRRMLPEVEKIYR
                     SGQLNNMSLVLNGAIVKTGGYGGYGYGYGYGYGYVDGSESCWKRLFRKKS"
     CDS             10526..11245
                     /locus_tag="ctg9_11"
                     /transl_table=11
                     /translation="MFGIFKSKYNLINSGLMKGMTDVHSHVLPGVDDGSPDINASLSLL
                     RYMESIGLRKVWLTPHIMEDYPTPNKKLRQQLDVLKAAYSGPLDLRLSSEYMMDATFTN
                     KLDGEVLPLGSSHLLVETSYMYPPPGLPDILMKIWNAGYQPVIAHPERYLYMEEKDYLL
                     LKEKGYSFQLNLMSLSGYYGPHPKVVSEKLLKQKMYDFVGTDLHHLERYRPMLDQLRLT
                     RRQLEALEGLIANNARI"
     CDS             11232..12236
                     /locus_tag="ctg9_12"
                     /transl_table=11
                     /translation="MRVFNCLSGGILCGLTLLLIFLPCFTPEWAGNLIFISLSAIPICI
                     ADGIIFAILLWKHNRWWMLYLLLLLGSSPILSGYFPLHFLHREEVPDSNQLKLVCWNAE
                     GFRLNKDTLAKAAHSIRILQPGIVCLQERPHTNLLAWDTIQAAFPDYPYCIINSREDEI
                     LNLAVFSRWPVGNVQEYYFPDSYNKMLQADIRMIGQTFRLFNVHLQTTGMNESSSMKDR
                     LQTMRHHAIRRNRQADLLANAIAESPYPVIVCGDFNDIPASYVYRKISRSLQDCFLQAG
                     RTWKGSYQRWGDFLRIDYTLCSPAFQVNCYQLVSNPWSDHKQQHCVLYLDKRS"
     CDS             12255..13100
                     /locus_tag="ctg9_13"
                     /transl_table=11
                     /translation="MTKENWTIEIKPKKKWLDIDLKGIWRYRDLYYMYVKRDIVTVYKQ
                     TILGPLWFLIQPIFTTVMYMFIFGGLAGISTDGVPQPLFYMAGIMLWNYFSSAFNVSSN
                     VFTANAGVFGKVYFPRLVVPLSGITSNLIKFGIQLLLFIAMYLYFYVKGASLHVNAALL
                     LFPFLTFLIAFHAMSWGLIVSALTTKYRDLTQLVTFGLQLFMYATPVIYPLNAAPEKYR
                     DIIALNPLTPIFETFKYSCMGCGSLDWGGLAYSTLFMLSTLFCAVVIFSRVERNFMDTV
                     "
     CDS             13129..14436
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 148.7; E-value:
                     3.5e-45)"
                     /gene_kind="transport"
                     /locus_tag="ctg9_14"
                     /transl_table=11
                     /translation="MNDIAIRFDHVGKLYKLGLVGTGTLSHDLNRWWKTTILRQEDPYL
                     KIGETNDRSKKGASEYVWALKDITFDVHQGDVVGIIGKNGAGKSTLLKLLSRVTSPTTG
                     AIRARGRIASLLEVGTGFHPELTGRENIYMNGSIMGMTRHEISHKLDEIVDFAGVERYV
                     DTPVKRYSSGMTVRLGFAVAAFLEPEILVVDEVLAVGDAEFQKKAIGKMQDVSKGEGRT
                     VLFVSHNMAAVRVLCKQGIVLNNGTVAYTGSIEDCVNYYIGNNISSFNTHTIINDKQRR
                     EKGAFLREIEFLEARLFNDPKTVGNNEPIELEIKLKKNITNIDVCQYTVNFTDDADVLV
                     ESFITAPIPVPKDKDEYTVRLKVSSHGLTKRCYHISFVAGLKDFSIGARNFDIVRDVLS
                     FEVSYYQKNPDKKYLIWYRDWGAVVHSNENIAVEVI"
ORIGIN
        1 gactctggtc ggggataatc tttattccga atccgtattt catctgccat ttacgtttca
       61 gggaaaccag accctgaaaa aatcattatc ctagtggaat ccctgcaaga cataaaccct
      121 gtggaacggg cattggtgaa caaagcgacg gcaaaccgta ctccgatcaa tgccactatt
      181 gaattgacac cgacgtgcaa tttccgttgt gatatgtgct atatccgcat ggagaagtca
      241 caagccgaga aaagaggagg attacggagc atagaggaat ggctgcacat tgccgaccag
      301 ctacaggaaa taggaacgct cttcatctta ctgacaggag gcgagcccct actctatcct
      361 gatttcaaag aattatatat ccggctgaaa gaaaaaggat tcatcctcac catcaataca
      421 aacgcgactt tgatagatga cgaaacagta cgtctgtttc aacgtttgaa accccggagg
      481 gtgaatgtct cgttatatgg tgtgaccaac ggaacttatc tcaatctgtg ccacgcgaca
      541 aacggtttcg accgttgcct ggaaggactg aaacgattaa aagaatatgg catagatacc
      601 aaactgaacc tcaccttgac acgacaaaat ataaaagaac accggcaaat gctggaacta
      661 gctgacgaat gggacttacc tatgctgacc aacagttaca tttcagtcta ttcacggccg
      721 ggatgcgcca ccacgctacc ccttgatacg tgccgccccg taccggatga agtggcacat
      781 gccgaggttg aggcactgga acataaatat ggcaaggaat acacatcata cgccactcat
      841 gtcctccagc aattggaacg tggagaatct cccgtacctg ctgaaggcat cggacttgcc
      901 tgccgggcag gtaaaagttc cgcatggatc aactggcagg gcgtcatgac tccgtgcgtc
      961 gatatggaaa caccagccgt ttcgctactt tccacaaccg taagcgatgc ctggaaacaa
     1021 atagtaacca aatgcgaaca acttccgttc cataaagaat gcgcaggttg taccttacgc
     1081 tctatctgtg atgtctgcta tgccaatgcc cgcaatgaaa aagggcaatg cggcggcatc
     1141 ggctaccttt gccgcattgc aaaaagtaaa aagaaacaaa tgaaaggaag tctataaaga
     1201 cttttctcat aaatacatat acattccaag ttatggatca tcttcacgat gccaaccttt
     1261 tggaacgggc attggtggac aaagccaatc agagccgtgt cccgatcact accaacttcg
     1321 agctgactcc cacctgtacg ctcaactgcg acatgtgctt catacgcacc gaacgcagcg
     1381 tggtggaacg gcacggaggt ttatcgcctt tgcaacaatg gctcgactgg gcagaacaac
     1441 ttcaagacat gggtacactc ttcatccttc tcaccggagg tgaaccgatg ctctatccac
     1501 acttcaagga gctgtacacc cggctgcgcg aaatgggatt catcctgact ctcaatacga
     1561 acggcacact catcgacaac gaaatggtac gcatcttgca gacccacaag ccgcggcgga
     1621 taaacgtcac cctgtatgga gacagcagag aaacttacgg acgcttgtgc cacaatccgc
     1681 aaggatacac cctgtgcatg gaagccctga aacggttgaa aaaggcagac attgatgtga
     1741 aactgaacgt aagtatcgta cgaaagaatg aaaaagatta cgacgagatc atccgtctgg
     1801 cccagcatct ggacattccg gcagaagtaa actcatacat gtttcctctc tcacgccccg
     1861 aatgcggaag tctgcgtaac attctaactg aaagactgga tgccgacgag gcggcccgca
     1921 tcgagatgca atatatggag tacaaaaaag ggaatgacat ggcacgatac atgcacgact
     1981 tgaaatatac gcttgcccat gtggaaggaa cacgagcctg ctctttggag tgcagagctg
     2041 ccaagagttc atgctggatc aactggcaag gcatcctcac cccctgtgtg atgctggatc
     2101 aaccggccgt tgacctgaaa aagattccga tgacaactgc atggcaacaa cttttagaag
     2161 aagccaagga actggtatcc cataccgaat gcgagggttg ccaccttcgt cccgtatgca
     2221 acgtatgcta tgccgccgca cactgtgaaa aaacaatcac cggaagcatg gactatcttt
     2281 gccagatggc gaaagccaaa gaacggatca ttacgaatta tccccccgta atacattaaa
     2341 aactgaagat tgtgagactg aatatcggcc cgctaacgat tgaattgtca ggagtgacag
     2401 aacaggagat tcctgttaac agccgtttgt ttctcgacca taaacccgct accaaagaag
     2461 cggaccggta ctatacattc tattttgtca accgtctgcc tttgccgtcc aacgactggc
     2521 agatcacatt ccaacgcaac gacatcgtag ttttccggaa ggaagaacaa gaaacacgcc
     2581 tgctggctgt aggaaacctg aatgcctgct atgctctcta tcaggaaaga aacgaaagag
     2641 atgccaacat ctatttcatc gaaggtctga aaagagaact gcaaacagat accctgttca
     2701 tttcctgcct gtgcctggaa cgtcctttat ctgtccaggg atgttacata ctacattgta
     2761 cttttctgga ttatcgtggg caagccatct tattcagtgg tcctagcggc attggcaaat
     2821 cgacgcatgc caacctgtgg tgccggcata ttcccggcac ccaggtactc aatggcgacc
     2881 gtgccctgct ctgtccactt ccaaacggcg actacgagat aacgggatgg cctgtatgcg
     2941 gttccagcgg tatctgtcac aatgaacgcc gcccgttgga ggccattgta ttcatcgaac
     3001 aggcatctga taacaccatc cgtccccaga cagccatgaa gcatttcaaa gctctctgct
     3061 cgcaggttac aatcaactgg tggaatccaa agctcaccgg caaagcactc gacgatctac
     3121 aggttttgac cagacagaca agcatcagca cctatgcgtg caacatgaat ccggaagcag
     3181 ccttcaccct gcacaggtat ctgaccaaac tggaaattat ccgataatgt gaaatacgcc
     3241 ccattatgaa gactgtcgat acgaaagaat atatatccat gctgcgtacc ctcattgagg
     3301 aaggaaagca ggtgagcatg atcatctcgg gcagcagcat ggctccattc ctgatccacg
     3361 caagagacca catctacctg aaaagcccct ccggtgaact tcggaaagga gatatggtgt
     3421 tctatcagcg aagcaacggt gaatatgtca tgcaccgtat ttataatgtt aaaaatgaag
     3481 aatattatct tatcggtgac gcccagactg tcatcgaagg tccaattcaa agagaacaga
     3541 ttttcgccat cattatcaag gtgaagcgaa aagggaaatg gatagttcca gaagatttcc
     3601 agtggaaatt cttcgcccac atatggccga acataattcc tttacgcagg accatcatta
     3661 aaacatatcg ttttttcaaa agatgaaaag aaccaaagaa tttatcaaac gaaacatagc
     3721 cggagaaatc gtactggttc cttccggaca gaccgcccga gagttcaacg gaatggtcac
     3781 cctgaccgaa accggagaat ttatctggga gcatatcgaa gaagcagaaa gcttcaacca
     3841 tctagtactg ttgattctgg aggaatacga agtggataaa gacaccgcat cgcaagatgc
     3901 cgcaggattt atcatgcaac tgctgcaagc cggcatgatc cgtcccacag gtataaactg
     3961 gtaaacagta atctgttcaa ttcagatatg acaaacaata caataagaaa tgttagaaga
     4021 gagattcgtt ttcttcgcga gaagcgccgg atctgtaaaa aatgttagat caggtaagtt
     4081 caagacccta tgttatcagc ggataataga atgaacttac attttattcc ccattacatc
     4141 tgcctgtgaa ggtcgatgta attttaacta taaataggat aatgcaataa tataaagaca
     4201 atgagactca attctaattt aattcttcgc caagtaggtg gagaatatat gattgtcaat
     4261 ccgttttctg aaaccatgga tatggcacag gtctattcct tgaatgaaac agccgcctgg
     4321 ttatggaaac aattggaaaa caaggaattc acggtagatg aagccggagc actgctgtgc
     4381 aatgaatatg aagtaaataa agatacagcc cgaaacgatg ccaacgagct gtgccgacaa
     4441 tggttagaaa ctgggttagc catagaataa gacaaaaaga tgatctcagc cccattacaa
     4501 aaggctttca tgcttttgct aaggcaagga ctgtgggacc ggcaggaaga ctgttccgcc
     4561 ctttttcctc tagatgaaaa ggaatggaat gaaattcaca gcatggcaag aaaacaaacc
     4621 gtacaaggca ttatttacga tggcatccgc ctgttgccga ctgaagccgt acctccccgg
     4681 aaggtattgc ttggctggat ggtggaagtt gacaccttgg aacgggtgaa ccggcaacac
     4741 cgggaaacga ttaaagccct ccaacagatt tatgtacaat caccttctat ccctttcctg
     4801 ctgctaaaag ggatagggac agctgacttc taccctcatc cggaacatcg catagccgga
     4861 gacatcgacc tgtggttcgg aaacaagaca caaaccgaac aagccaacca acggatggaa
     4921 aaattaggat taccggtaaa aagaggaacc aatggtgagg cttcctgtct gataaacaga
     4981 gttctgattg aacatcacag caggctgata gagttgcaca accctttcct ccaaaaagaa
     5041 atccgccaat gggaagcggg ggtctttacc aacagccaag gcaaacttcc gagcgaagcg
     5101 aatcatctat tactttccac ccacatattg aagcatctta tcaatgaagg gatcggacta
     5161 cgacaattgt gtgatatagc catggctttt aacgcattac attctgttac aaacaaaaac
     5221 gaattagagt gtatctgtcg caaatggcac attcaccggt ggaaccggtt actttatgcc
     5281 ctattgataa aatatcttgg cgtgccggcc gaccttttac cattcagtac cagtctctgt
     5341 ccggacaagt taatgcaaga gatttgggaa agtggcaatt ttggacatgg agacgaacgt
     5401 tacggtgaac gtcccaccgg gaaatgggcg aacaaacgat acacgttgaa gcggatcttt
     5461 cacaaaatgc acttatcgtt aggttatgct ttcgacgaaa ctttctggtg gctggccgga
     5521 ttagccctct tacgtttcaa ggaaatgata aaaaagaaat gaaagaattg ctgaaaaaat
     5581 ttttgcagaa gctcacacgg gagaatctga gcaatacatg tcagttagga tggaaagctt
     5641 tcaaatgggt tatgcaggta acagaaggat accattggct catcaccttc tctatctttt
     5701 cgggtatttt cggagtggtc atgtcattgg tcaatgtggc catgtccaaa tggatcatcg
     5761 atgtagctac cggagcacag gaagggaata tttacctggt agccacaata gtagccttat
     5821 ccttcctgct gggtatgggg ataaaacttg tatctccctg gatttttggc aagatcaaca
     5881 tgcgcatcag tatccgcatg caaaattcgc tgtccgacgc cctaatgatg tgttcatgga
     5941 aaggagcagg gaaatggcac acaggcgacc tgctgacccg tatcagcagt gacgcttccg
     6001 aagtgttggg aatgggaatg ggcattctac ccaacctgct ggttaccggc ttgcaattgg
     6061 caagctcttt tatctacttg tggattcttg acgcgcgttt agcttggttc atactgggag
     6121 tcacccctct tgttttattg tcaaagattt atttcagaaa ggtccgggaa ctgagctgtg
     6181 cccaaaaaaa gatgaacagc gagatgggta ccgtcatgca agaaaatctg tccaaacgga
     6241 ttctagtccg ctcgctcgga gccaccaact accggaaaca gaaattacat gaaacacaag
     6301 agaagttgtt caaattggga atggaacaaa tcaaattttc cacttttacg caaggggtca
     6361 tgggatttac atttggagga gggtacttat gtgcattcct ttggggtatt ttccaactgc
     6421 ataaccacga gataacattc ggaacaatga cagcctttct tcaactggtc ggacaggtac
     6481 agggaccttt tttagggtta atatccatcc ctcccagtct gatacgggga tggacctccg
     6541 tggaacggtt aatggccctc tttgaagatg tagaaccgga cgaacacccg gtctacatag
     6601 accaaccact gacactgaac tttcggaaag tgtcttttgg ctatgaagag ggacagccgg
     6661 tactcgaccg gtttacagct gcctttcatc cgggaagttc caccgccata gccggaccta
     6721 ccggaacagg aaaaacgacc attatccggc tgatactggc tttggtttat ccggaaaagg
     6781 gacgcatcga tttgacaact gatgacggac ggacactcag tgtgaccccc gatttacgca
     6841 tcaacttcgt ctatgtgccc caaggaaata cgttgctgag cggtaccatc cgggagaatt
     6901 tatggctggg tagtccggga gcagacgaag aggctctgca taaagtcatc cggctggcct
     6961 gcgctgaatt tgtgttcagt ctgccggaag gactagatac caagataggg gaacatggat
     7021 atggcttgtc tgaaggacaa gcccaacgga ttgcaatagc ccgcgcactg ttgcgtcccg
     7081 ggcggatctg gctgtttgat gaagcatcat cggcacttga caccgagacc accacacacc
     7141 tcatggacaa tttgttgcaa tggggaaaga ataacacatt aatatttgtg acacacgatt
     7201 cacgactgat ggaacgatgt gaccaagtga ttcatataaa ggaataaaaa acaattaatt
     7261 ataaaacaat ggataaaaca atcaaactgg cctgtctgtt ggcaataatc atttttagtt
     7321 cgtgcgcttc acgcaaagat tttgtctatt tacaagatat ggatgaacta caggaatatc
     7381 ctatggttca aaaatatgaa gccatcatcc atagggatga cagattgagt attattgtga
     7441 acagcaaaaa cccagaactg tccctgcctt tcaatatgtc cggaagcaga agctattctg
     7501 tagaagcaga cggaagcatt tccaacaatg aagtgggggt attaagtgat gaaaaagaaa
     7561 aaggttattt agtggatatc aacgggaata tagactttcc tgtgctggga caactgcatg
     7621 tggaaggact gacccgccga caattaaccg aactgatcaa gaaacgactg atcaacgaag
     7681 aattgctgaa agatcctatg gtcaccgtca atttccttaa cttcaaattt tccgtgctgg
     7741 gagaagttgg acatgtagga acctttgaag tgaaaggcga ccgcatcact cttctggagg
     7801 ctcttgccat ggccggagac ctgacccccc gatcccgtct ggaccgtatc gccgtcatcc
     7861 gcgaatatgg gaacaagcga cgaatcctgt tccacgacat ccgcagtaaa gacatcttca
     7921 catcgcctta ctattacctg caacagaatg acatcgttta cgtagaaccc accaacatga
     7981 aggccaccga acaggcccag agaaaactga gcacgtggag tatgatcctg tccttcatca
     8041 ccacaatcac ctcactggtg ttgttaacta ctaaataaaa aagaaacgac atgataagaa
     8101 tgagtgaaca aaaagatatg tcgggagata agaccttaag cgggggagga ttcaatatca
     8161 accccgttga catcatcatg tacctgttgt ccaaatggta ctggtttgta ttgtcggtca
     8221 gtctgttcgg cggatatgca tggtatcaat atgccaaact tccctttatc tattcacggt
     8281 cagccaccgt catgataaag gacgcctatt caaacaacat cggtcgcggg ctggaccgtt
     8341 ttaacaccta ttcatatacc aatgtatcca atgagatcct gcaattccag tcacacaaac
     8401 tcatgcgcga tgtggtgaac cgtcttcacg ccaatgtatg ctacctcatc atggatgact
     8461 tgcgtgagga ggaactttat acgcaagccc ctgtcaaggt ttcattcccg gaagaagagg
     8521 atcatcttga tttcagcctg acagtcagaa tcctgaacag gaagcaagtc cggttatccg
     8581 atttctcgac agacgccaca agtataacgc tgacggccaa tctgggtgac actatccagt
     8641 cgcccgtagg aaaaatagtg gtctcaccca ccttatatta tacagacaag tggttcaaca
     8701 caccgattac gatacgccgg cagagtacgg acacaatggc cagcctattc agaagcaacc
     8761 tgaacatcag ccaagctgag aatgacgcct ccatcctcta cctgtcactc cgtgattact
     8821 ccaccgcccg tgccgaagat gtgctcaata tgctgattac agtgtataat gaagagacta
     8881 tcaaagacaa gaaccagata gccatcaata cctccagctt catcaacgag cgtctggtca
     8941 tcatcgaaaa agaactggga ggcgtggaaa acgaacttca gtcctacaaa cagaacaatg
     9001 acatcatcga tatcggttca gccgcttcca tgtccatgtc agacaaacgg cagtacagct
     9061 cgaccactca ggaactggaa ttacaggcac gcatggcacg ctacatcaag agctacctgg
     9121 tggacccgtc caaagaaacc gagcttatcc cttcaaacac cggcatagcc gacatcaaca
     9181 ttgaaaccca gataacggcc tataatgcca acaagttgaa acgagacaaa ctgatagaag
     9241 gaagcagcga caagaatccc atcgtccagg aactgaacaa gaatctgatt gccatgcggc
     9301 agaatatcat ccgggccatc gacaatatga ttgtcagcat cgatgtgaaa ctgaacgagg
     9361 cacgaagcag ggccggagaa gcccagtggc gggtaaccaa catacctaga caacagcagc
     9421 aaatgctttc tatcgaacgt cagcaacgca tcaaagagga actttacctc tatctactga
     9481 acaaacgcga agaaaatgcg ctgagccagg ccaccaccga aactgacgcc cgtgtgctcg
     9541 atcctgctgg aggaggggat gctccgattt ctcccaacgg acgcagcatg atcatggcag
     9601 gtgtcataaa aggaatcgcc ctgccggcca ttgtcctgct attgttcctg ttcttcgata
     9661 cccgtatacg caaccgcaag gacatcgagg atgctgtaac cgttcctttc ctgggcgaaa
     9721 tacccaagga ttcatccaaa gggaaaacag agaataaaga aacggcacat ggcattgctg
     9781 tccgtgccca agggcgtgac attgtatcgg aagccttccg cataatacgc accaacatgg
     9841 attttatgcg tgtcaagtca aagaacatgc aagtcgtcac tttcagctcg ttcggaccgg
     9901 gtgccggcaa gacatacgta tccagcaatc tggcagccag cttcgcgcaa accgacaaga
     9961 aggtcatcct gattgacatg gatatccgta aagggacttt gacttcacat acccgcctcc
    10021 acacaaagga aaaaggaatg acctcttttc tggcaggcaa ggccacaacg gatgaaatca
    10081 tcaagcacaa cgagatctgt gaaaatctgg atttcattcc ggccggtccc atcgccccca
    10141 acccgtcaga gctattgctc agcgaacaac tggaagtact gataaccgaa ctgcgcaacc
    10201 gttatgacta tatctttgtc gacaatgtgc ctgtaggagt ggtggccgat gccgccatca
    10261 ccaaccgcat agccgacctg accatcttcg tggtacgggt tggcaaactg gaccgccgca
    10321 tgttaccgga agtggaaaaa atttatcgca gcggacaact gaacaacatg tcgttggtac
    10381 ttaacggggc catagtaaag acaggcggat acggaggcta tggatatggt tacggctacg
    10441 gctatggtta tgtggatggt tccgaatcat gctggaaacg gctgttcaga aagaaatcct
    10501 aaaatccccc caaaaaagaa gtaggatgtt tggtatattc aagtccaaat acaatttgat
    10561 taattctggt ttaatgaagg gtatgaccga tgtccattcc catgttcttc cgggagtgga
    10621 cgacggttcg cccgacataa atgccagtct gtccctgctg cgctatatgg aatccatagg
    10681 gttgcggaaa gtgtggctca ccccccatat catggaggat tatcccacac cgaacaagaa
    10741 gctgcgacaa cagctcgacg tgttgaaggc ggcctattcc ggcccgttgg atctacggct
    10801 gtcttccgaa tatatgatgg atgccacttt tacaaacaag ctggatggag aagtgctgcc
    10861 tttaggcagc agccacctgc tggtcgagac atcctacatg taccctcctc ccggtttgcc
    10921 ggatatcctg atgaaaatat ggaatgccgg ttatcaaccg gtcatcgccc acccggagcg
    10981 ttacctgtac atggaagaaa aagattacct tctgctgaaa gagaaaggtt acagctttca
    11041 actcaatctg atgtcactga gcggttacta tggcccgcac cccaaagtgg tcagcgaaaa
    11101 gctgttaaaa caaaaaatgt acgattttgt gggtacggac ctgcaccatt tggagcgtta
    11161 ccggcccatg cttgaccaat tgaggttgac ccgaagacaa ctcgaagctt tagaaggtct
    11221 gattgccaac aatgcgcgta tttaactgtc tgtcgggagg tatcctgtgc ggtctgacac
    11281 tgctgttgat atttctcccc tgcttcactc ccgagtgggc cggaaatctt atcttcatca
    11341 gtctatcggc gattcctata tgtatagccg atgggattat tttcgcgatt ctgctttgga
    11401 aacataatcg ttggtggatg ctttacttgc ttttgctatt aggtagttca cctattctat
    11461 ccggttactt tccgcttcat ttcctacata gagaagaagt gccagattcc aatcagctaa
    11521 aactggtttg ctggaatgcc gaagggttca gactgaacaa agacaccctg gcgaaagccg
    11581 cccatagcat tcgtatcctg cagcccggca tcgtctgtct gcaggaacgt ccccatacca
    11641 atcttctggc atgggacacc atccaggctg cttttcccga ttacccctat tgcatcatca
    11701 actcgcggga ggatgaaatt cttaatctgg ccgtcttcag ccgctggcct gtcggaaacg
    11761 ttcaagagta ctacttcccg gacagctaca ataagatgct tcaagcggat atccggatga
    11821 tagggcaaac tttccggtta ttcaacgtcc atctgcaaac taccggcatg aatgaatcat
    11881 cctcaatgaa agacagactc cagacgatgc gccaccacgc catccggcgt aaccgacaag
    11941 ccgatctctt ggcaaacgcc attgccgaga gtccttaccc ggtcatcgtg tgcggtgatt
    12001 tcaacgatat accggcttcg tatgtttacc ggaaaatcag ccggtcactg caggattgct
    12061 tcctccaggc cggccggaca tggaaaggca gctaccaacg ctggggcgat tttttacgaa
    12121 tagattatac gctctgttca cctgcattcc aagtgaattg ttaccaactg gtttccaatc
    12181 cctggagcga ccacaaacag cagcactgtg tgctctatct ggacaaacgc tcctaaaaaa
    12241 caagatttca aaaaatgact aaagaaaact ggacaataga aataaagcca aagaaaaaat
    12301 ggctggatat agatctgaaa ggtatatggc ggtaccgtga cctatactat atgtacgtga
    12361 aacgcgacat tgtcaccgtg tacaaacaaa ctattctggg tcctctctgg ttcctcatcc
    12421 aaccgatctt cactaccgtg atgtatatgt tcatattcgg tggcctggca ggtatctcga
    12481 cggacggagt accacagcct ttattctaca tggcaggtat catgctgtgg aattatttca
    12541 gttccgcgtt caacgtatcc tccaatgtgt tcacggccaa tgcgggcgtg ttcggcaaag
    12601 tctacttccc ccgtctggtc gtgccgttgt ccggcatcac ctccaacctg atcaagttcg
    12661 gaatacaatt gttgttgttc attgccatgt atctctattt ttatgtgaaa ggagcttcac
    12721 tgcatgtcaa tgccgccctg ctgttgtttc cgttcctgac atttctgatt gcattccatg
    12781 ccatgtcgtg ggggttgatc gtatcggcgc tgaccaccaa ataccgtgac ctcacccagt
    12841 tggtcacctt cggcctgcaa ctgttcatgt atgccactcc ggtcatttat ccgctaaacg
    12901 cagctccgga aaaataccgt gacatcatcg cgctcaaccc gttgacaccc atattcgaga
    12961 cctttaaata cagctgcatg gggtgtggtt cacttgattg gggcggattg gcatatagca
    13021 ctttgtttat gctctccacc ctgttctgcg cagtagtcat cttcagccgg gtggaacgca
    13081 attttatgga tacagtgtaa gcagcagaat taaaaaaaga gaataagaat gaacgatata
    13141 gcaatccggt ttgaccatgt aggcaaactc tacaaactcg gtctggtcgg caccggcaca
    13201 ctgagccacg acctcaaccg ctggtggaaa acgaccattc tccgccagga agacccctat
    13261 ctgaagatag gcgaaaccaa cgaccgcagc aagaaaggcg cgtcggaata tgtctgggcg
    13321 ttgaaagaca tcaccttcga tgtgcatcaa ggcgatgtag taggcattat cggaaaaaac
    13381 ggtgccggga agtccacctt gttgaaactt ctgtcgcgtg tcacctcccc taccaccgga
    13441 gccatccgtg cccgtggccg cattgcctct ctcttggaag tcggtaccgg tttccatccg
    13501 gagctgaccg gccgtgagaa catctacatg aacggctcca tcatgggcat gactcgccac
    13561 gaaatctccc acaagttgga cgagatagtc gactttgccg gtgtggaacg ctatgtagat
    13621 acccccgtaa aacgctattc cagcggcatg accgtccgtc tgggctttgc cgtagccgct
    13681 tttctggaac cggaaatact ggtagtagat gaggtacttg ccgtaggtga tgccgaattc
    13741 cagaagaaag ctatcggcaa gatgcaggac gtgtcgaaag gcgaagggag gacggtgttg
    13801 tttgtgagtc ataatatggc ggcggtacga gttctttgca aacaagggat agtactcaac
    13861 aacggaactg tagcctatac gggaagtata gaggactgcg ttaattatta tataggtaat
    13921 aatatatctt ctttcaacac acatactatc atcaatgata aacaaagaag ggagaaagga
    13981 gcatttttaa gagaaattga atttttggaa gctcgcttat ttaatgatcc aaaaactgta
    14041 ggcaacaacg aaccaataga actggaaatt aagcttaaaa aaaacattac taatatagat
    14101 gtctgccaat ataccgtaaa tttcacagat gatgctgatg tattggtaga atcattcata
    14161 actgcaccga tccctgttcc aaaagacaaa gatgaatata cagttcgtct gaaagtttcc
    14221 agccatggat taaccaaacg ctgctaccac atctcgttcg ttgcaggatt gaaagacttc
    14281 tcaataggtg caagaaactt tgatattgtg agagacgtat tgtcattcga agtaagttac
    14341 taccaaaaga atcccgacaa aaaatatctt atatggtaca gagattgggg agctgtagta
    14401 cacagcaatg aaaacattgc tgtagaagtt atctgataat caaaaataat atagccactt
    14461 tatgatcagc
//
