LOCUS       c00059_gnlPro..        16323 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MLPCBOIO_59.
ACCESSION   c00059_gnlPro..
VERSION     c00059_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 03:12:58
            Original ID  :: gnl|Prokka|MLPCBOIO_59
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16323
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16323
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2771:6323](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2772..6323
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16323
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16323
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(199..1413)
                     /locus_tag="ctg59_1"
                     /transl_table=11
                     /translation="LNSFKMTKKALYIFNPEHDLALASGETNYMAPASARQMASELALL
                     PMWYAEEGSVVLAPSAYNLDYVKKIQELLGLSVDLMTEPELASERNLDIRPWGWDIAIR
                     KRLLDLGVEESELPSIEQLDKLRFCSHRSCAVGLLPQLQLGACFCGESFYLTFPEEWKS
                     FVESHDTCLLKAPLSGSGKGLNWCKGVYTPSISGWCSRIGKQQGGVIGEPLYNKVEDFA
                     MEFRSSSNGRFGFAGYSQFRTGGSGAYEGNLLISDAAIERNLLEYIPVEEIYKLRDRLE
                     QELSLRFGTIYNGYLGVDMMICRFPESPVYRIHPCVEINLRMNMGVVARHIYDHYIYPT
                     STGAFQISYYPTEGTAWRAHKEMEEAYPLEIEQGRIKSGYLSLVPAHKKSSYRAWVFIS
                     KSVFL"
     CDS             1561..2739
                     /locus_tag="ctg59_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2772..6323
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_3"
                     /sec_met_domain="PFOR_II (E-value: 8e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 9.3e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 9.3e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.9e-11, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 3.2e-11, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 5.1e-08, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00026, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.6e-24, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6476..7342)
                     /locus_tag="ctg59_4"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFFG
                     EVYGEARVGLVVPQYVTIHSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7363..8187)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg59_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.6e-28, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8184..9410)
                     /locus_tag="ctg59_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9710..10048)
                     /locus_tag="ctg59_7"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10132..11427
                     /locus_tag="ctg59_8"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11567..14407)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 63; E-value: 1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg59_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 2.3e-19, bitscore:
                     63.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYTKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKVMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDQLIQLSH
                     QLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQRRMLLLVQRNVNILL
                     RLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAVARKKHIHFSFDYMPDTDYR
                     TLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIRFTVANTGSMISAEH
                     IRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQGTIFTVDLPVQTCET
                     VVSENSPAFSVSATSVTSTDATTSAVAGVPATPATSGYSGSSSLNDALTYEEEELEKSY
                     DSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPG
                     MDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVR
                     NLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGL
                     SRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCY
                     REQFGESPTDLLKRKG"
ORIGIN
        1 tttaggtttt aaaaaatatt gagtaaacta acttaggtat aacaagcgaa gttgtcaact
       61 aaatccagta cagtacacac atggcatgtg attacttgtt tcatgcaatg aaactttttg
      121 tttctcggtg tggaaccaat ggtttcacta catgaaacta tcagtttcac accgagaaac
      181 cataacttcg atataatatc acaaaaacac gctttttgag ataaacaccc acgcccgata
      241 actactcttt ttatgagccg gcaccaatga caaatagcct gattttattc ttccttgttc
      301 tatttccaaa ggataagcct cctccatttc tttgtgtgct ctccaggctg ttccttccgt
      361 agggtaatag cttatttgaa aagctcctgt tgaagtagga tagatataat ggtcataaat
      421 atgacgcgct actactccca tattcatcct caagttgatt tccacgcaag gatgaatccg
      481 ataaacagga gattctggaa agcgacagat catcatatcc actcccaaat aaccattata
      541 aatggttccg aaacggaggg ataattcttg ttcaaggcgg tcgcgcaatt tataaatttc
      601 ttcgacaggg atatattcca aaagattccg ttcgatggct gcatctgaaa tcagcagatt
      661 accttcgtac gccccacttc cacccgtacg gaattgagag tatccggcaa agccaaatcg
      721 accattactc gaagaacgaa attccatagc aaaatcttcc accttattat atagaggttc
      781 gccaataaca cctccttgct gtttgccaat gcgtgagcac caaccggaaa tagaaggagt
      841 atatacacct ttgcaccagt tcagcccttt cccgctaccg gataaaggag ctttcagtaa
      901 acaagtatca tgtgattcta caaatgactt ccattcttcg ggaaacgtca ggtaaaaaga
      961 ctctccacaa aaacaggctc ccagttgtag ctgtggtaat aatcccacag cgcaggaacg
     1021 atgggaacag aaacgcagtt tatccaattg ctcaatagaa ggaagctcgc tttcttccac
     1081 tcccaaatcc aacagtcgtt ttcttattgc tatatcccag ccccaaggac gaatatccaa
     1141 attccgctcc gaagcaagtt caggttctgt catcaaatca accgaaagtc ctaataattc
     1201 ctgtatcttc ttcacatagt cgagattata agcggaagga gccaatacaa cacttccctc
     1261 ttctgcatac cacatcggca acaaagccaa ttcggatgcc atctgccggg cggaagccgg
     1321 tgccatatag tttgtttcac cgctggctaa cgccaaatca tgttccggat tgaatatata
     1381 aagagccttt tttgtcattt taaacgaatt caaaacttta ttctgcaaat atatacagga
     1441 aatagtcagg aatggctaca ataaacagaa agttctaatt aaactcacaa ttttgccatc
     1501 tctactttgc aaatcctaaa aaaagcagta tatttgccac ccgaaaaaca aagaactgaa
     1561 atggaatcat tctatcgcac acacgcctac ctcgttgagc acaccaatgc ccccgttcgc
     1621 cgcgatctta tggacgagat cgactggagc gaccgcctga ttggtatcaa agggacacgt
     1681 ggcgtaggaa aaaccacttt ccttctccaa tacgccaaag aaaaatttgg gaacgaccgc
     1741 tcctgcctgt tcatcaacat gaacaacttc tacttctctg gccacagcat tgtagacttt
     1801 gctaacgaat ttcagaaacg tggcggaaaa gtattgttga tcgaccaggt gttcaaacat
     1861 ccggaatgga gcaaagagtt acgcatgtgt tacgaccgtt ttcctaacct gaaaattgtc
     1921 ttcaccggct cgtccgtgat gcgactgaaa gaagaaaatc ttgaattacg tgatatcgcc
     1981 aagagctata acctgcgcgg attttctttt cgcgaatacc tgaacttaca gacaggcatg
     2041 aaattcaggg catacagcct cgaagaaatt cttagcactc acgaacagat tgccaaagga
     2101 gtactctcta aagttcgtcc gctggattac ttccaggatt acctgcatca tgggttctat
     2161 ccgttcttcc tcgagaagcg taacttctcg gagaatttgc tgaaaacgat gaacatgatg
     2221 gtggaagtag atatacttct catcaaacaa attgaactga aatatctttc aaagataaaa
     2281 aaattactat atttgctcgc tgtcgacggg ccgaaagctc caaatgtgag ccaactggca
     2341 agcgacatac agacatctcg cgccacggtg atgaactata tcaagtatct ggcagatgcg
     2401 cgactcatta atctggttta tccgaaaggg gaagaattcc ctaaaaaacc ttcgaagata
     2461 atgatgcaca actccaacct gatgtattcc atctacccgg tgaaagtgga ggagcaggat
     2521 gtgctcgaca ctttctttgt gaattcttta tggaaagacc ataaggtaca taaaggagat
     2581 aaaaacgtct cttttatggt ggacgaagta atgccgttca aaatttgcca ggaaggagca
     2641 aagatcaaga acaatccgaa tgtgacgtac gcgttgcata aggctgaaat aggtcggggc
     2701 aaccagatac ctctctggat gttcggcttt ttatattaaa agatttattt acttaaatat
     2761 ttaatttagt tatgactaaa cagaagaaat tcatcacttg tgatggtaac caggctgcag
     2821 cgcatatctc gtatatgttc tctgaagtag ctgctatcta ccccatcact ccttcttcga
     2881 ctatggctga gtacgtagac gaatgggctg ccgcaggacg taagaacatc ttcggcgaaa
     2941 cagtattggt acaggaaatg caatctgaag gtggtgctgc cggtgcagtt cacggttctc
     3001 ttcaggctgg tgcgttgact actacttaca ctgcttctca gggtcttctc ctgatgatcc
     3061 ctaacatgta caaaattgcc ggtgagttct tgccttgcgt attccatgta tctgctcgta
     3121 cattggcttc tcacgcattg tgtatcttcg gtgaccacca agacgtaatg tcagctcgtc
     3181 agactggctt tgcgatgttg gctgaaggct ctgtacagga agttatggat ttggctggtg
     3241 ttgctcactt ggctactatc aaatctcgtg ttccgttcat gaacttcttc gatggtttcc
     3301 gtacatctca cgaaatccag aagattgaaa tgttggaaaa tgatgatctt gctccgctga
     3361 ttgatcagga agctttggct gaattccgtg cccgcgcact gaatccgatg aatccggttg
     3421 ctcgtggtat ggctgaaaat cctgaccatt tcttccaaca tcgtgaatca tgcaacaact
     3481 actatgaagc agttcctgct atcgtagaag aatacatgaa tgaaatttct aagattacag
     3541 gtcgtaaata cggtttgttc gattattatg gtgcagaaga tgcagaacgc gtaattatcg
     3601 ctatgggttc tgtaacagaa gctgcccgcg aagctatcga ccacttggta gcaaatggcg
     3661 aaaaagtggg tatggttgcc gtacacctgt atcgtccgtt ctctgctaaa cacttcctgg
     3721 ctgctgtacc taagactgcc aagactatcg cagttcttga ccgtactaaa gaaccgggcg
     3781 ctaacggcga acctctttac cttgacgtta aagactgctt ctacggcgca gaaaatgctc
     3841 cggttatcgt tggcggtcgc tacggtttgg gttcaaaaga tactactcct gctcaaattc
     3901 tttcagtatt cgagaacttg gccatgccaa tgccgaagaa tcacttcact atcggtatcg
     3961 tagacgacgt tactttcact tctcttcctc aaaaagaaga aatcgcttta ggcggtgaag
     4021 gaatgttcga agctaaattc tacggtttgg gtgctgacgg tacagtaggt gctaacaaga
     4081 actctgtaaa gattatcggt gacaacactg acaaacactg ccaggcttac ttctcttatg
     4141 actctaagaa gtcaggtggt ttcacttgtt ctcacttgcg tttcggtgat actccgatcc
     4201 gttccactta tttggtaaat actccgaact tcgttgcttg tcacgttcag gcttacctgc
     4261 acatgtacga tgtaactcgt ggtttgcgta agaacggttc tttcttgctg aacactatct
     4321 gggaaggtga agaactggct aagaacctgc ctaacaaggt taagaaatat tttgcacaga
     4381 acaacatttc cgtatactat atcaacgcaa cacagattgc attggaaatt ggtttgggta
     4441 atcgtaccaa cactatcctt caatctgcat tcttccgtat cacaggtgtt attcctgtag
     4501 accaggctgt tgaacagatg aagaaattca tcgttaagtc ttacggtaag aagggtgaag
     4561 acgttgttaa caagaactat gctgccgttg accgtggtgg tgaatacaag actttagctg
     4621 ttgatcctgc ttgggctaac ctgccggatg atgcaaaagc tgaaaacaac gatcctgcat
     4681 tcatcaacga agtagttcgt ccgatcaatg cacaagatgg tgacttgctg cctgtatctg
     4741 cattcaaggg tatcgaagac ggtacttggt atcaaggtac ttctaaatac gaaaaacgtg
     4801 gtgtagccgc attcgttcct gaatggaatc cagaaaactg tatccagtgt aacaagtgtg
     4861 catacgtttg tcctcacgct tctatccgtc cgttcgtact cgatgctgaa gagcagaagg
     4921 gtgctaagtt cgaacaattg aaagcagtag gtaaagtatt cgacggtatg acattccgta
     4981 tccaggttga cgttctcgac tgtctgggtt gcggtaactg tgctgacatc tgtccgggta
     5041 atccgaagaa gggtggcaaa gcattgacaa tgaaacacct cgaaagccaa ttggctgaag
     5101 ctgacaactg gacttactgt gctgaaaacg tgaagactaa acaacatctt gttgatatca
     5161 agtctaacgt gaagaactca cagttcgcta ctccgttgtt tgagttctct ggtgcttgct
     5221 ctggttgtgg tgaaactccg tatgtgaaat tgatttctca attgttcggt gaccgtgaaa
     5281 tggttgctaa cgctaccgga tgttcttcta tctactctgg ttcagttcct tctactccgt
     5341 atactacgaa cgaaaacggt cacggtcctg cttgggctaa ctcactgttc gaagacttct
     5401 gtgaattcgg tttgggtatg gaattggcta acgaaaagat gcgtgctcgt atcgtgaagt
     5461 tattcaacga aatccttgct gccgacaacg cttcacctga agcaaaagaa gtgctgaaag
     5521 catggattga aaacatgtac gatgctgaca agactaaaga attggctccc caagtgaaag
     5581 cagtgattga agaaggtctt tctcacggat gtcctatttg caaagaactg aaaggactga
     5641 ctcaatatct tgtaaaacgc agccaatgga tcattggtgg tgacggtgct tcttacgata
     5701 tcggttatgg tggtcttgac catgtaatcg cttccggtaa ggacgttaac atcctcgttc
     5761 tggatactga agtttactct aacacaggtg gtcagtcttc taaggctact ccggtaggtg
     5821 ctatcgctaa gttcgctgct gctggtaagc gcgtacgtaa gaaagacctc ggtctgatgg
     5881 ctactactta cggttatgta tatgttgcac agatcgctat gggtgctgac caagctcaaa
     5941 ctctgaaagc tatccgtgaa gctgaagcat atccgggacc atctttgatt atcgcttacg
     6001 ctccatgtat caaccacggt ctgaaagcag gtatgggtaa gagccaggaa gaagaagaaa
     6061 aagctgttaa gtgcggttac tggcacttgt ggcgttacaa cccagctttg gaagaagaag
     6121 gcaagaaccc attccaattg gatagcaaag aaccgaactg ggaagatttc caaggtttct
     6181 tgaagggtga agttcgttac gcttctgtaa tgaaacaata tcctactgaa gctgaagaac
     6241 tgtttaaagc tgctgaagaa aacgctaaat ggcgttacaa cagctacaaa cgtttggcta
     6301 gagaaaactg gggtgctgaa taatagtaat accctataaa tataaagcgg taatcttatc
     6361 aaagattacc gcttttttat tgtatgaact ctgtccaaca taaacagtac tccctttttc
     6421 ccactagagt tcatgtctat tttatattta aaattaagaa taacaatgct ccaatctatt
     6481 tattctctga cttcggaatc caactatcca ccaacagccg atgctcatcc ctccatttac
     6541 gggctatttc ttcttcatcc atcctggcat ccttcatagc tgtcataaaa gagctaagtt
     6601 cttctgtcgt tagtttgatg ttgccaaaga attcggcagc aaacggatct ttctcactga
     6661 atcctttcca tgcaatagca tgtatttctt ccaagtctcc atatactttc ttcggatcat
     6721 ccaagaattt caagtcaaac tggtcgaaca tccaatgcgg tgtccacccc gtaatgacaa
     6781 tccattctcc tttgtccatc gcttttttca aagaagccag catggtggaa ctacttgaag
     6841 tcatgagggt atacccatca agtccgtaag cagcaatggc cttatcggtc gtcttcatta
     6901 tccctgctcc cgcatcaatt cctactattt cagaggaaaa acggtcttta ttagcttcca
     6961 gctcattaat agagtggatc gtaacatatt gaggaacaac cagtccgacg cgagcttctc
     7021 cgtatacctc cccaaaaaat tcgatgctgt ctccatactg atccatataa tctttcatcg
     7081 ttattggtaa ccatgcatcc agaaacacat ctgatttctt tcctgacata gatacaaaaa
     7141 taggggcaag atcagcattt tgcaattcaa cctcatatcc atgctcttcc aataccacct
     7201 tagccaaatg actcatggca ataccttcca gccaattggc ataggctatt tttactttct
     7261 ttttctctaa gtctgaatta gtacaggaag ctagcaaaag catagctgac aatactattc
     7321 ctactatttt atatattctc atacgtattt tatcctttcc gtttagttct tattttttcg
     7381 tcctgccatt ccttgcgtga tacggtctaa gatgatagct aaaataacaa ctgctatacc
     7441 accttcaaac ccaagtccga ttttcatttg ggtaatacct ttcaatacaa tttctcccag
     7501 accaccggca gcaatcatgg cagcaattac aaccatagaa agcgacatca ttattgtctg
     7561 gttgacacca gtcagaatgg tgggcaacgc caaaggaagc tgcactttat acaataactg
     7621 ccaacgggta gctccgaacg aacgggaagc ttccactaca tttttaggaa cttgccggat
     7681 tcccaatccg gtaaggcgga ccacaggagg catagcaaag ataatggtgg caaacactcc
     7741 tggcactgct cccaatccga aaaacaaaac agcaggaatc agataaacaa aagcaggcat
     7801 cgtctgcatc aagtcgagaa caggacggag tattttctct gcacgcgaac tgtttgccgt
     7861 ccatactcct aaaggtacac caacaatcag ggccagacag gtagatgaaa aaacgagagc
     7921 tagagtttgc atggtagcct cccagaatcc cattccatag atcagtaata atcccaatgc
     7981 ggtgaaaatt gccgtaccgc gtcctgcttt catccatgcg agtgcagcaa gtaccaaaat
     8041 ggttatataa aaaggtattc cgaaaagtat gtgttggaat cctataataa aactaccgat
     8101 gcccgcattc acggcatcaa agaaagtgga aaaatgtatc atcatccaat tgatggccat
     8161 ctctatatat tgtcctatat ttatcataaa tctattgcgt tttgaattat ttcgtttatt
     8221 tcttctttat ctttcccggt cacttcgatg attaaggatg aaagcgggat tgttcctaaa
     8281 aactcgcgcg tctcatcaat cacccatacc ggcgaattgc tctttgtcat tagaggaagt
     8341 atatcctcca acaccgtatc ctccaacaca gaatgtactt ctgtacgcac aatcgtttca
     8401 atggattttt cctgtttgct acgtaactta agcaagtcgt tcagacgtac ttctccgacc
     8461 agtttatcat cggcgtctat gacaggtaat acggtgatat tcttcgcacg catcttacga
     8521 atcaatactt cgggaccttc tttcttcaga cgggccacca acggtttgtc aatcattaaa
     8581 gaagaggcgg taataatttt gctcctatcc acgttttcaa caaaacgggc tacataatcg
     8641 ttagccggtt cagtcaggat ttcctccgaa gtacctacct gcaccacttc tccgtctttc
     8701 atgatggcaa tacggtcacc tagcttaatt gcttcactca agtcgtgggt aataaaaaca
     8761 atcgtctttt tcatctttga ttgcaaggcc agtagttcat cctgcatctg tacgcgaatc
     8821 agaggatcga gagcagagaa agcctcatcc attaaaagca cttcaggatt attagccaga
     8881 gcgcgagcca gtccgacacg ctgttgcatt ccaccggaaa gctcgcctac catctgattt
     8941 tcatatcctt tcaatccgac aagcttcatg ctttccatcg ctttcttctc acgttcctct
     9001 ttcttcactc cctgaagttc gaggccgaac gcgatattgc tcaatacgga acggtgaggt
     9061 aacagaccga aattctggaa aaccatcgcc agctctttcc gacgaacctg caataattct
     9121 ttttcggaaa ttttagatat atctactccg tttacaagca cttgcccggt agtaggacgt
     9181 atcagacgat tgatacaacg cagtaatgtc gattttccac ttcccgagag tcccattatc
     9241 acgaaaaact ctccttcatt aattgaaaga ttggcatctt tcactcctac cgtacaaccg
     9301 gtatctttca gaatttcctc tttactctta tcttttttca acatcttgag ggctttctgc
     9361 ttctcgttac caaagataag gtacaaatcc tttatttcta ttttactcat ataatatatt
     9421 ggtttagatt ataatatttg ttttgttttc aactgccgca ttccttattc tcacttacga
     9481 taaacaagtt gaatgttcgc atggttcagt catgtcacat gataacatga cggtccgacg
     9541 ttttttaaat ggttaaaaaa aaacagacag agtagtttaa aaggaataga atttgataag
     9601 attatcctct taatgaacag tagaaaacag tattttcata aataaataac agtctgttct
     9661 tgcatattgt tggcacaaag gtaaggaaaa tagattaaat atgcaaattt cattcaggta
     9721 cggagtaatt ccaaagatgc tttttcaagt ctacgcatcc attttgtttg aaagagatcc
     9781 cttcttccaa caagagttgt ttctgctctg tccaacccgg aacaagccgt cccgacgcat
     9841 tgacaacccg atgacaaggc gcagataaat catccggaat ctgtttcaaa gcacgcccca
     9901 ccatacggga acattgagac attcccaata atgcggcaat tcccccatag gtagaaactt
     9961 tacctaccgg aatttctcgg acaacctgat acacctcttg acaaaaggat gcggaaaggc
    10021 tcgccttatc tactttataa tctttcatca ctcaaacatt actttatttc agttccaaaa
    10081 ctagataaaa agaaaagaat ttgcaaataa taaaagcatt tcaaataaaa tatgcaactt
    10141 tatttgcttt atttacaaat aatcccgacc tttgtaccca ttaaaagcaa ccctattatt
    10201 aacaaaacaa gcactgctgt tatgaaaaag aaaactatcc tgttcgcttc ttgtttattg
    10261 ggagcactgg ctttcagctc ctgtgagaag aacctttatg atgaaagtaa acaacccgag
    10321 aaagaaaaga agatgactga cttggaagta cctgccgatt tcgactggaa aggttctcaa
    10381 aatgccaaag tgaaaattgc cagtcaatca actgctacta tttctgtatt tctagaagaa
    10441 aattgcaatg aagaggcttt gatgcttcga atggatgtcg atgccaacac atcaaaattg
    10501 gaactcccaa ttgaaattcc tgcatatata aaaaatgtgt atgtaaaata tggtaatggc
    10561 tctgaaatac aaactgttcc tgttgaaagt aatggtacta tttctatagt agtacctgct
    10621 aacgctacgg cattatccag agttaccaca agagctaata aagaagttga aacgaacaac
    10681 atcttcaatt atccgggata tggcaacgga actattatgt tcgaagatat gtatccagct
    10741 ttaggcgatt atgattttaa tgattttgtt gcatggtata atttccaaat tgacggtttt
    10801 tattggagtc acaatcaatg ttatgcagaa tacttaatga taggattcca aatcagagct
    10861 ataggaggta tatatgacta caatccttat atccgcttgg cagaagtaca atataatgaa
    10921 cttgatttag aagaaactca aatgtatctt gagcgtaaca atcctgaaga ggctgaaaat
    10981 atcaaaatcc taaaaggccc aaaaggggaa ttgattattt cactaaagaa accggccatt
    11041 cctaacggat acaagtatta taatacggag gtaaatgaaa aaacaaagcc taaaaaaatg
    11101 atggccattt acttggtgtt caactcacct gttaacgtta aaagcctaca agacagtaaa
    11161 atggactttt atattgcaaa aactaataaa ggacaagaaa tccacttaaa aggttatagc
    11221 ccggtttatt ataacagcaa cgaaagttat gtaaatgaag acaactttat atggggatta
    11281 aaagtacctg catctttaca tcatgccaga gaagaagtaa acttcttgga agcatatcca
    11341 gactttgaac aatgggtaac atcgggaggt caagagaacc aaagatggtg gaataagcca
    11401 aaaacgaata agttgattat gaattaataa atatacagta aatcatatac tgaattaaat
    11461 aagaggtaag gtatgtcaat agatttcctt acctcttatt tttatcatat gaattctaga
    11521 agtataaaca gataaatgct caccaccaaa ttttgcagat tctatcctat cctttcctct
    11581 tcaacaaatc tgtcggactc tctccaaact gttctctata acatttagta aaataagaag
    11641 gagaactaaa accaacttca taacctatct ctgccactgt catatccgac gaagcaagca
    11701 gggaagcagc tttcttcaaa cgagctatac gaagcagttc attcggggaa taattagtta
    11761 gggatttgat tttgcgatag agttgcacac ggcttaatcc catatcttta cccaagtctt
    11821 ccacattcaa atttgaatct cccatctttg cctcaatcaa agctttgaat ttttccacaa
    11881 agtctttatc catatcacag acatcctctt tcgccaacgt ttgtccgtca ccaaaaaact
    11941 gtttcaggcg gcggtgtgaa tctatcagat tacgaacgcg tgccaatagt aattgcgaac
    12001 tgaaaggctt ggagatataa gaatctgcac caccatcata cccttgaatt cgttgttcat
    12061 ccaaagaaca agctgtcaat aggataacag gaatatgaca ggtttgtaat tcgcttttca
    12121 agcgacgaca acattcaatt ccatccattc cgggcatcat tacatcggag ataatcaagt
    12181 ccgggacata tttcatagct ttacgaatac cttccgagcc gtctgcagct tctataacag
    12241 tataatcagt atgaagcaat ccatgcacat ataagcgaat atcagcgtta tcatcaataa
    12301 tcagaacgca aggtttggaa gagtcgtaac ttttttccaa ttcctcttct tcgtaagtta
    12361 aagcatcatt caagctcgaa gaaccggaat aaccggaagt tgcaggagtt gccggaaccc
    12421 cagcaacggc agaggttgta gcatcggtgg aggttacaga agtagcagac acagagaatg
    12481 ccggagagtt ttcagaaaca acagtctcgc aagtctgcac aggcaaatca acggtaaaga
    12541 tagttccttg cttttcatca ctttccaccg tgatggtacc tttatgcaat tccacaaaag
    12601 cctttaccaa tgccagtcca atacccgaac cggcatggtg catatctatc ttatagaaac
    12661 ggtcgaaaat attccggata tgctccgcag aaatcattga accggtattg gcaacggtaa
    12721 agcgaatcca gcaatgatcg tctttagtca gggaagacaa gcgtacagtt acttttccgt
    12781 tttccggagt aaatttgaaa gcgttggaaa ggaggttgaa atagatgcgt tccaactttt
    12841 ctacatctgc caatgtgcgg taatccgtat ccggcatata atcgaatgag aaatgaatat
    12901 gcttcttccg ggctactgcc atgaaagatt cgttccatcc ttcaaaagaa gaaagaatgt
    12961 ctaacgaaat aggagtatat tccatttttc cattctcgta tttacgaaaa tccagaatct
    13021 gattgacaag acgcaaaagg atattcacgt ttcgctgaac taacaataac attcggcgct
    13081 gatcttcact caaagacgaa tcagccagta aatgctctac cgggtcggca actaatgtca
    13141 gtggagtacg aaaatcgtga gatatatttg tgaagaaaac cagcttggca tgagtcgctt
    13201 cttccagttg atgagaaagc tggataagct gatcccgttg ctcttcgagt ttatcgcgct
    13261 gttgctctac ttgtttcttc tgttcggaca actctttatt caggcgattc ttggaacgga
    13321 gggatttata gactaccaac aacaatcccg ctactaataa aagaataacc aagccgccat
    13381 acatcacgac ctgctgcgta gctacacgcg acagataccc accgatacgt ccgttcaatg
    13441 tttcaatctt ctgatccagt tccgagatat gggtagtctg aagttgcata acgtgcgcgt
    13501 tcgtgcggtc tacaacggca gtattcatga ccgtttcgcg aggataagac ttcttctcaa
    13561 gaatattcat ggccagttgc atcactttgt ccccattagt cggataaata aaagttgcat
    13621 ccagcacatt gtcaagcacc aattcaagcc cgtttccttt gccgggcagg gcatcaatgc
    13681 caacaaaaat cattaccttt tcacgtccgg ctttcttcgc agcttgatag gctcccggag
    13741 cgatacggtc gttatgtgca tataccgcat caatcttcgg atgacggcga agcatactat
    13801 ccatttccac ttctgccggt tcacgttccc aggcagcatc cgctttatca atcagtttga
    13861 tatccggata attgctgata gcagccataa atccctgatg gcgttccatg gcaggggtgg
    13921 aaccacccag tccggtaagc tccactacat tccctttccc tttcagactt gatgcgatat
    13981 aatttcctac cgcacgacct atttcataat tatcggcacc gatataggca gtatatttat
    14041 cagaaagtat cttccggtct acaagaatga caggtattcc tttctgatag gcctcctcca
    14101 caattggagt catgggagcc gcttcattgg cggaaattat cagtaaatca actcctttat
    14161 ctataaaata atgaacatct tccgcctgct tacggttatc atccgccgcc gagcggattt
    14221 caaccgacac tccatcataa aacatcgctt cgcgaagaat ctcatcattc atcttgtgcc
    14281 tccaagagtc atcgctacat tgggccaccc caatacggaa acgaggcgca tcctgccgac
    14341 aggccgccaa gcccaaaaga caaaacaaga ctgttatcca cttcgtatat ttcatcgctt
    14401 caatcattcc ctttctttcg tatatctttt gtatttcttt ctgtaatcca aatttctccc
    14461 cccgcattat ttgcattcac caccgggaaa tacatcagtt ccactttcac agggttcagc
    14521 gtatattttc cagtaaagcg tggaagcaaa ggaaccgtaa actgataagt acctaccggt
    14581 aatttttcgc taaagataac agttttctct ttaaaatact cacgatatac ttcagaacgg
    14641 gagaaattaa caggttttga ggcataacta caacctgccg gaacaggaac ttcgagcatc
    14701 acatattgcg caccctcctg tttcacctgc aaggtaactg tcaatgtaac aggtacaccc
    14761 gccaccaaag agtctttttc caaagtcacc tccaccttga aagcatcact ctgacgagca
    14821 ttcatcacac gcttcattga atagacacta tacaataaag gctcttttcc cgtttttgaa
    14881 ataagcagac tgtcgcttgc tgtcagccgg gcatgataag gaaattccgt aattcgttga
    14941 tgatccttac cgctcacaga caccgacgtt cctgacatcc ctccggaacc tgccagcaaa
    15001 tcggtcagaa cagttgccac agccgaagaa gcctgatacg tattccatcc gcgctcctta
    15061 gtccgcaaaa tatacaattg catattttct ttcaacttac acagggaagg gtcattttta
    15121 ataatccggt aggctatcaa tgtatttatc atctgatttc cctcccaata ataagtacgc
    15181 cgtccgtcgt cacagtaaac accttccagc atatcctttt tcagataagg acgtacgcta
    15241 tcacccacat tcaccgaatc cacctgttgc ttgatttccc agagaagcag cttctctttc
    15301 aagtatgaaa gaggacgata atacttgttt ctatttgcca acgagtcttc tttctgttcc
    15361 aattgccgga cgaaaggttc caataatctg actgccgaag aataatccgc ctctactttc
    15421 cactcatgca gagcatgaag tatttctata tcttccagtt tcattcctcg ataaggacgc
    15481 gtatgagcat actccacttt caaaccattc agattcaact ccacaggata acctgcatct
    15541 tgcgccatct tcaaagcccg cagaatatgc gcagacatcc agaaagaagt attttcagag
    15601 ttcccccacc acgaccataa ctgatgtttg ttctgatgat tcgtcagtcg atggatgata
    15661 ggtcgaattg ctttatctac tttcaccttt tcacccttac tctgcatata ctgttggtaa
    15721 gccaacaaac cgattaactt ggatgccagc tgctcattgc acaaatattt gtatcctgtc
    15781 aagtaattca ctgattcttt atagatgtcc aactgattgt cagtgatact caccatcact
    15841 tcttcatcct cgccggattg cactttaacc gtctttgcat cggacagaat acccaatgtg
    15901 ccctccgcca attcagttcc ctgtgccagt atcggaatcg tatattcctc tccatcctga
    15961 tagccatcgt cgcgagtgaa aagatagctg atggtcacgc tatcggcatg aactgcctgc
    16021 atcggcactg tttcatgaaa tccctccatg aaactcactt cctgccgttt caacgtatcc
    16081 gttccgacgc agaactgtgt ctttccggct atgtgctgcc catccagata attgcggata
    16141 gtcccgacca ccgtactctg atccccctcc accaagaagc ggggagtttt caactccgcc
    16201 atcaacggtt tgtaagagcg gacgaaacgt cggaaagtac ccgtctgcaa acgacggttc
    16261 atgccataaa cgacagtttc ccatttcgtc acattatcgg ggaaagttgt ttcaaactgt
    16321 acc
//
