LOCUS       c00135_gnlPro..        14702 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OPMKIGFG_135.
ACCESSION   c00135_gnlPro..
VERSION     c00135_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 07:34:46
            Original ID  :: gnl|Prokka|OPMKIGFG_135
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14702
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14702
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[490:4702](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      491..4702
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14702
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14702
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             491..4702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_1"
                     /sec_met_domain="HGD-D (E-value: 9e-23, bitscore: 72.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 6.7e-34, bitscore:
                     108.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVYKVGLDIGSTTTKMVVLDKDGTTVLFSGYKRHQAKIQECLLG
                     FLYQIKEQLGDIPLSFHITGSVGMGISEKCSLPFVQEVVAATNYVCREHPHTATMIDIG
                     GEDAKVVFFQDGQATDLRMNGNCAGGTGAFIDQMAILLGVSIDELNELALRSNQVYSIA
                     SRCGVFCKTDIQNLIAKNISKENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTF
                     IPALRKAFANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSV
                     TSPFQSDLSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLD
                     NNHRILYSYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFH
                     MDAGIIETIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSF
                     ISTFAQSLDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSY
                     SVVKNCLYKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGAL
                     GCALYAKQIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNNDNHYFSGNRC
                     EKVFSNKGSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFT
                     ACGIQVQLSAPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTLQNVNRIFMPFVVFE
                     KKDKQQQNSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKDEALLYKQCYEYLKSLGIR
                     DEVCKNAFSRALQEQYAFEEKIAAYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVS
                     DMIAAMGVYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMTS
                     FGCGPDAFLIDEVRNLLKRYGKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQAK
                     DPEPFVSTAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGL
                     KYSNNEVCYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIEN
                     GYTNTPVVSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERG
                     QAARLRDLYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFN
                     PFAQKDVTSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKV
                     QKQINKVNEIGKNFNYFTPFESIFEKAEKAKQVISPGTQFGEGWLISGEILSFASQGVN
                     HVISLQPFGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNIN
                     N"
     CDS             4707..5327
                     /locus_tag="ctg135_2"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEE"
     CDS             complement(5517..5699)
                     /locus_tag="ctg135_3"
                     /transl_table=11
                     /translation="MLRGTMDVLTDSASKEMIWQEGDTMYYPEGVTDPDYCVLKFTAIS
                     GRFYSNFKSEDFVVE"
     CDS             5905..6099
                     /locus_tag="ctg135_4"
                     /transl_table=11
                     /translation="MLPTVFSASLIILLFIIGLLSDAKVEKCQESNAIKRKVEIALFTV
                     CVLYDTITEFLPYAAGSYG"
     CDS             complement(6032..6910)
                     /locus_tag="ctg135_5"
                     /transl_table=11
                     /translation="MKNSIPRYTFYKHKYGSELLVDVVELKYVKKFLAKSAVHTLNYYD
                     ITFITEGKGAFSVDNQTYEAIPRDVLFSKPGEIRNWDTHHITNGYALIFEEEFLSFLFK
                     DSLFVQHLSFFQIESSSSLLHLSDELYTRILETLHDIKMEIDSYQQGDVHVLRALLYEV
                     LMLLDRAYLKMTSIEEGRSREVSNNHVSKFMNLVATHAKEQHSVQYYADKLCITPNYLN
                     EMITSTMGISAKQYIQSKVMEEAKRLLVYTDFPIADIAFELCFSTVSYFIRSFRQHTGE
                     TPLLYRKVHKP"
     CDS             complement(7034..7582)
                     /locus_tag="ctg135_6"
                     /transl_table=11
                     /translation="MEAYLKKLCFEYQVDEREVKELLARMEMVYLDKGETIASATLPEQ
                     SLYIIVSGILHTYTTHEGEERTNRFFSAGDAVLCYNSSQYSIKTLTKCAAYYISEEEIE
                     ELCASSISFANLVRQLMEYQFYFKEEEDMNARKLTVRERYLSLLAEIPDILYRVPLKHI
                     NHYLGADVTSLGYLAGSSK"
     CDS             complement(7623..8987)
                     /locus_tag="ctg135_7"
                     /transl_table=11
                     /translation="MKELDLTQGSVPKVLLQFAVPFLIANVLQALYGGADLFVVGQYDD
                     SASVAAVAIGSQVMQTITGIILGITTGTTVLIAIATGAKDNRKVAFTIGSSVWLFSITG
                     VVLTLVMVLFHSRIAELMHTPVEAMVDTKNYILVCSLGILFIVGYNVVCGILRGLGDSK
                     TPLYFVGLACVINIVLDFILVGYFHWGATGAAIATVTAQGVSFGIALWFLYRHGFHFDF
                     SRKDIRLNRNLSKKILVLGAPIALQDALINVSFLIITVIVNQMGVIASASLGVVEKIIV
                     FAMLPPMAISSAVATMTAQNYGAGLIKRMNKCLASGIGIALVFGVSVCVYSQFLPETLT
                     AFFTKDAAVVAMAADYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRI
                     PLSYWFSQIDSSSLFIMGFAPPISTVVSLLICIWYLRYTQRKLYLRGTMMPAMSN"
     CDS             complement(9224..10789)
                     /locus_tag="ctg135_8"
                     /transl_table=11
                     /translation="MENESSLLSFRHIYYRGKLNSCNYTCSYCPFGKKSHLADTTQDEQ
                     AWNRFIAAIEQWKGEPLQLFIIPYGEVLIHRYYRKGMVHLAALPQVAGISCQTNLSFPA
                     KHWLDEIRVAPTVISKIRLWASFHPEMTSVEKFAHQIHILHHAGIQVCVGAVGNPSAKA
                     VLNDLRNALLPDIYLFINAMQGLRAPLSQEDIQFFSQLDNLFEYDLKNAPVQWEVCAGG
                     RDNCFIDWKGDMYACPRSRVKIGNFYQGDGAVVPLSCKRKVCDCYIAFSNLNNHPLHRI
                     MGEGAFWRIPDKPLITTVFFDVDGTLTDSQGKVPESYANALRYMAQSVSLYLATSLSME
                     QAKKKLGKALFDLFRGGVFADGGLLSYSRQIKCLPVKVYPEVYGESSKVTIHSYEGVVY
                     KYSILVRDKEQRESILTRLKENPCQVFHKAPLITVIHPEASKKEGMLQLCKALGLASEH
                     TLVVGNSLKDWPMMSVVSHSCAVMNAEPLLKECARYTLNPDRLAAFFRFSNGDPIDQTS
                     SDNS"
     CDS             complement(10801..12078)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg135_9"
                     /sec_met_domain="Radical_SAM (E-value: 1.4e-16, bitscore:
                     51.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQPLPRYVDYMYSYPHKTAYRSFPSPVSLVPYLKQVEGQKASLY
                     FHIPFCSHKCGYCNLFSLQTNRADYIATYLETLHKQAQQLSPLTTGLAFDSFAIGGGTP
                     LLLTVPQLEYLLDTAALFGVHPSHTFTSVETSPEYADPTRLDLLKQAGVARVSIGVQSF
                     LDEELTALKRRPRRDMINQALEAIRKRQFPFFNIDLIYGIRGQTVASFLYSLEQALLFQ
                     PNELFIYPLYVRPGTAITERESDDVCFQMYCAACDLLKDRGFLQTSMRRFIHHPSTDAE
                     ISCGDEVMLSCGSGGRSYLGNLHYATRYTVCQRCIAGEIDDYMGTTDFTVARNGFILSQ
                     EERRQRFIIKNLMYYMGLDKAEYKRRFGESPDNVMLFRQLAERQWIENTDNGRICLTSD
                     GMAYSDYIGQLFITPEIRELMETYSY"
     CDS             complement(12075..12929)
                     /locus_tag="ctg135_10"
                     /transl_table=11
                     /translation="MQIDELPAGEQTQNPDLDMNQVVGTHDILMLCFDTLRYDVSKEEE
                     EAGRTPVLNSHGGEWEKRHAPGNFTYPSHFAIFAGFLPSPAEPHSLRSRKWLFFPVQAG
                     TGRIPPAGSYPFTEATFVQSLANVGYETICIGGVNFFSKRNELGRVFPGYFTKSYWLPT
                     FGCTAPDSTEKQIDFALKKLENYPEDKRIFMYINFSAIHYPNCHYVEGKMKDDKESHAA
                     ALQYVDSQLPRLFQAFQKRGNTLVIALSDHGTCYGEDGYEYHCISHETVYTVPYKHFIL
                     TKK"
     CDS             complement(12916..13926)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg135_11"
                     /sec_met_domain="ATP-grasp_3 (E-value: 4.6e-09, bitscore:
                     27.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIIVVSNSLSKRIEYFIEAGKHLQVEVRFMTYGELFNCLPQLRQ
                     AVIKLEPCVSDETNFLKYALLNQAYKETLQRLGEMRLSDDVCFLNTPHALLRALDKKET
                     KQVLMDRGLKVTPMLPSPRSFDELRELLADCGRGCFLKPRYGSGAGGIMAVRYQPNRNK
                     WVVYTTLQQVDGVIHNTKRINRLSTEKEMIPLAEAVMQTEAILEEWIPKEQLQGENYDL
                     RVVCRESEIDYIVVRCSKGSITNLHLNNKAHWWNELSLPEVVRQQIYFQCQEAVQSLDL
                     QYAGVDVLIERGTDIPYIIEVNGQGDHVYQDMFAHNSIYIQQIKNIKKRYNHANR"
ORIGIN
        1 aagcagcata gccaaaagaa aatatagcag aactgtaaaa tataaaagag gttgtgccaa
       61 cgttttgaca caacctcatt ttgtttataa ttcagcttaa aatctctcgt ctgatcctag
      121 aactgttcta caatagttta taataaactc gaataccgtt ttactaaaac tatcaaaaag
      181 tttattataa acagaatccg ggtttattaa aagccacgtt accttttgtc aaaaatagag
      241 taaacaagat ttctaagatt caccataaaa gatctactac aacccaacaa gtaatataaa
      301 tacacaatta ttcatttacg tcttttttta cacgatcgtt ttcctccctc acattccatc
      361 tttctttttt cccaattcgt taattaaatc aaaaacttca attacgattt gccgtatcta
      421 ccatattttt acatacattt gcgtctgaca cagatgtcaa acacgaggtc taatttaaga
      481 tatttggtat atgaatgtat ataaagtggg tttagatata ggctctacta ccactaagat
      541 ggtagtattg gataaagatg gaactacagt cttgttttcc ggatacaaaa ggcatcaggc
      601 aaaaatacaa gaatgtttac tcggatttct ttatcaaata aaggaacagt tgggtgatat
      661 tcctttatct ttccacatta cgggctctgt tggaatggga atttcagaga aatgctctct
      721 gccgtttgtg caagaggttg tagctgcaac aaactatgtg tgccgggagc atccgcacac
      781 agccactatg atcgatattg gaggagaaga tgcgaaagtt gttttctttc aggacggaca
      841 ggctacagac ctgcgcatga atggaaattg cgccggcgga accggggctt tcattgacca
      901 gatggctatt ctgcttggag tctccatcga cgaattgaat gaactagcac ttcgttccaa
      961 tcaggtatac tctatcgctt cacgctgcgg agtattctgc aaaacggaca tacagaatct
     1021 gatagccaaa aatatatcta aagaaaatat agcagcttcc attttccatg cagtagccgt
     1081 acagaccact gtcacacttg cacgcggttg caatatcgta gctccggtat tactctgcgg
     1141 tggcccattg acttttattc cggcccttcg aaaagcattt gccaactatc tgaatctgtc
     1201 acaagataca gatttcatat taccggaaaa aggaaatctg atccctgcct ggggagcagc
     1261 attggcagag aacaatgaag aaagtattca tctctccaac ctgatacagg taatagaaaa
     1321 caaactaagt gttacctcac ctttccagag tgatctttct cctatattcg acagtgagga
     1381 agaatatcgg tcatggaaaa aagaaaaaga ccagtataaa attcaatatg ccagtctgcg
     1441 tcccggatta caggaagcaa ctatcggcat agactccggc tctactacca ccaaaatcgt
     1501 agtactcgac aacaatcatc gtatccttta ctcctattat cacgacaaca acggaaaccc
     1561 tataaaaaca gtagagaacg gcttgcagaa actatatgaa gaatgccgga gacgaggaac
     1621 taccctgcgc ataaaaggag gatgttctac cggttacgga gaagatctga taaaagcggc
     1681 tttccacatg gatgcgggaa tcattgaaac catcgctcat tatgctgctg ccaaacatat
     1741 cagcaaagaa gtttctttta tcctggatat tggagggcag gatatgaaag ccatctttgt
     1801 gaacgacgga gtaatcaaca gaatcgaaat caatgaagcc tgttcctccg gttgcggttc
     1861 ttttatcagc acatttgcgc aatcgctgga ttacagtgtg gaggactttg ccaaagcagc
     1921 ttgtttttcg caagcaccat gtgatctggg tacacgttgc acagtcttca tgaactccaa
     1981 agtaaaacag gtacttcggg aaggagcgtc cgtagcggat atagctgccg gattatctta
     2041 ttccgttgtt aaaaactgcc tgtataaggt tctgcaatta aaagacacgg agatacttgg
     2101 cgaccatatt gtcgtgcagg gaggaaccat gcgtaatgat tccatcgtac gaagtctgga
     2161 aaagctgacc gggaaacaaa ccttccgcag taactgtcct gaattgatgg gtgctcttgg
     2221 ttgtgcccta tatgccaaac aaatcgaaaa tgcccgggtg acggagctga acgagatgct
     2281 ccaatgggcg caatatactt ccaagcaact tcaatgccgg gggtgcgaga accagtgcgc
     2341 cattatgcga tatacgttca acaatgacaa ccattacttc tccggcaacc gatgtgaaaa
     2401 ggtattttcc aataaaggaa gccatgcgga caaaggcatc aatacgtatg ataaaaagct
     2461 ggaattatta ttcgaccgga gcgcagacat tccacaaccc ctatttacca taggcattcc
     2521 acgtattctg aatatgtatg aggaataccc tttctggcat accttattta ctgcttgcgg
     2581 cattcaggta cagttgtcgg ccccctctac attcagcaaa tacgagactg ctgccggcat
     2641 ggtgatgtct gataacatct gcttccctgc caaacttgtg cacagtcata tccgtaacct
     2701 gacactgcaa aacgtcaacc ggatatttat gccgttcgtt gttttcgaga aaaaggataa
     2761 gcaacagcaa aacagctata attgccccat cgtttccggt tattcggaag tcatcaaaag
     2821 tgtacaggaa gagaatatac cgatagatgc tccgactatc accttcaaag atgaagcatt
     2881 gctgtataaa caatgctatg aatatctgaa atctttgggt atcagggatg aggtatgcaa
     2941 aaatgccttc tcacgcgcat tacaggaaca atatgctttc gaagaaaaaa ttgctgccta
     3001 taatcaggaa gttctgaacg agggacggga aaaacacaaa ctgattatct tactcgccgg
     3061 acgcccttac catagcgatc cactgataca gcacaaggtt tcggacatga ttgctgcgat
     3121 gggagtttat gtgataactg atgatattgt ccgccagcag gagatttcat tggaaaagac
     3181 tcattacctc tctcaatggg catttaccaa ccgtattctg aaagcaacca agtgggcggc
     3241 aatgcaagag ggtgacatac aatatatgca gatgacttct tttggctgcg gtccggatgc
     3301 tttccttata gatgaagtac gtaacttgct gaaacgatac ggcaagaatc ttactttgct
     3361 caagatagac gatgttaata atatcggctc catcaaatta cgagtccgct cgttggtgga
     3421 aagcttgaat ttcagtttga aacattctca agcgaaagat cccgagccat ttgtttcaac
     3481 tgctcctttc accaagaaag acaaaaagaa gaaaatcctc gctccattct ttacgccttt
     3541 catttcacca ctcattccat ccatcatgaa agtggccgga tatgaaatgg aaacgttacc
     3601 gttgagcgac accgcatctt gcgactgggg attgaaatac tccaataatg aggtatgtta
     3661 tccggcaaca ttgattgtcg gcgacatagt aaaagccttt aaaagcggac gttatgatcc
     3721 tgccaatacg tgcgttgcca tcacacaaac cggtggacaa tgtcgtgcca gcaactatat
     3781 ttcactgata aaaaaggcat tgattgagaa tggatacacc aatacaccgg tggtatcact
     3841 tgctttcggc agtggtattg aaaatgagca atccggtttt aaagtaaact ggctcaaggt
     3901 tttgccaatc atacttgcgt ctgtgttata cagtgattgt atcgctaaat tctattatgc
     3961 agccgtcgtt cgtgagaaag aacggggaca ggccgcccgt ctgcgcgatc tttatctgga
     4021 tacagcacag cccatcatcc agaaaaataa accggaggac ttgttgagtt acttatatct
     4081 cgctgccaga gacttcaaca aaatctgtga acagagatcc tgtcacaaag taggtattgt
     4141 tggagaaata ttcctgaagt tcaacccttt tgctcaaaag gacgtcacct catggctcat
     4201 caaccagaag atcgaagtga ttccgccact gataagtgat ttcttcatgc agggatttgt
     4261 caacctgaaa gtgagacaga accaacactt gcagcgaaaa ctcactcccg actttgttat
     4321 cgactggtta tacaagaaag tccagaagca gattaataaa gtgaatgaaa tcggcaaaaa
     4381 tttcaattac ttcacgccgt tcgaatcaat ctttgaaaag gcagaaaaag ctaaacaagt
     4441 catctccccg ggcacccagt ttggagaggg ttggctgata tccggtgaaa tactatcctt
     4501 tgcttcccaa ggagtcaatc atgtcattag cttgcaacct ttcggatgca ttgccaatca
     4561 cattgtagaa aaaggaatag aaaaacgtat aaaatcgctg tgccctcaaa tgaatatact
     4621 atctttagac tttgacagta gcgtcagcga tgtgaacata acaaacagat tattactttt
     4681 tattgacaac ataaacaact aaaattatgg ctacaacgga acatagcgat ttagagcagc
     4741 aaataataaa aactgcccaa caacttttta tagaaaaagg atttgtggag accagcatga
     4801 gtgatattgc tgcaacggta ggaatcaacc ggcccacttt acattattat ttcagaacca
     4861 aagataagat gttcaaagcc gtgttcggct cgatagtcat gtctttaatg ccgaaaatac
     4921 aggatatagt aaaacaggat atcccattta tggagcgact aagcatgatt ctggatgagt
     4981 atattgagct tttcacaagt aatccctgtc ttcccagatt catttgcgga gaaatacagc
     5041 gtgatgtaaa ccacttgctt gccactgcaa aagaacttca gttcggagat gctttatccc
     5101 aagtgaaaga cagtatactg acagcaatgg aagacggtaa acttaaaaag gttccgatac
     5161 atattgtatt tctgactgtc tacagcctat tgagctatcc atttcttgcc aagaacctga
     5221 tagtatcttt attcttggaa gatgaagccg cttttgctga cttcctgcaa gaatggaaac
     5281 aaaacatcat caaccaattg cagaacttat tgtgttatga ggaatagtat agatactata
     5341 taaggaggtg tgtcataatg aataataaaa cgcagattaa cgcaaattat cgcagattat
     5401 tccaattata ttgatatatt aatcaacgac ttataaaatt atttctgcga taatttgcgt
     5461 taatctgcgt tttgacacac tccgttatta ccattccaat caccccatct tgcaccttat
     5521 tcgaccacaa aatcttccga tttaaaatta ctatagaaac gtcctgaaat agcagtaaac
     5581 ttcaatacac agtaatcggg atccgtcact ccctccggat aatacatggt atctccctcc
     5641 tgccagatca tctctttact ggcactatcc gtcaagacat ccatcgtacc gcgtagcatg
     5701 acacctctaa agaatctcgt atcacagaag tagatacacg catggttgtt ctcacggtat
     5761 tgcgccacac gcatggacga agtatttgtt gtcagataaa tagtttttat cccctttctt
     5821 tttctgggtt gcagcattgc tttgatggta ggaaatcctt caccgtctat cgaaccgata
     5881 aaagctgttt tcagcttatc aatcatgttg cctactgttt tttccgcgtc tctcatcatt
     5941 ttacttttta ttattggttt attatctgat gcgaaagtag agaaatgcca ggaaagcaat
     6001 gcaataaaaa gaaaggtaga aatagcactt tttacggttt gtgtacttta cgatacaata
     6061 acggagtttc tcccgtatgc tgccggaagc tacggataaa ataagaaacc gttgaaaaac
     6121 agagttcaaa tgcaatatca gctataggaa agtccgtata aacaagcagc ctcttagcct
     6181 cttccatcac cttgctctga atatattgtt ttgcgctgat tcccatggtc gaggttatca
     6241 tctcattcag ataattagga gtaatgcaga gcttatccgc ataatattga accgaatgtt
     6301 gctcttttgc atgtgtagca accaaattca tgaatttact tacatgatta ttggaaactt
     6361 ccctacttct gccctcctct atcgaagtca ttttaaggta agcacggtcc agcaacatca
     6421 ggacttcata aagcaatgct ctcaaaacgt gtacatcgcc ctgttgatac gaatcaatct
     6481 ccatctttat atcatgcaag gtttcaagta tgcgtgtata aagctcatca gacaaatgta
     6541 gtagcgatga agaactttct atctgaaaaa acgaaagatg ctgtacaaac aaagaatctt
     6601 taaagaggaa agacaaaaat tcttcttcga aaatcagagc atacccattg gtgatatgat
     6661 gagtatccca gttccggatt tcccccggtt tagagaaaag aacgtcacga ggaattgctt
     6721 cataggtttg gttatcgact gaaaaagctc ccttaccttc tgttataaaa gtaatatcat
     6781 aataatttag agtgtggaca gcacttttag ccaggaactt cttcacatac ttcagttcta
     6841 ctacatcgac caaaagttca ctcccatact tatgcttata aaaagtatat cgaggtattg
     6901 agtttttcat tcagaataca aaaatagtat tccttaccaa ataatccaaa gacttttcaa
     6961 attcgattcg attgaataag ccatgaacca tctgataagg aatacataga aaaatatgtc
     7021 taggttatat ttcctattta gaacttccgg ccagatatcc caaactggtc acatctgccc
     7081 ccaagtaatg attaatgtgc ttcaatggca ccctgtacag aatatccgga atttccgcca
     7141 ataaagagag gtacctttcc cttactgtca gcttgcgggc attcatatcc tcttcctctt
     7201 taaagtaaaa ctgatactcc atcagttgac ggaccagatt cgcaaatgaa attgaagatg
     7261 cacacaactc ttcaatctcc tcttcactga tgtaataagc agcacatttc gtcagtgtct
     7321 tgatagaata ctgacttgaa ttatagcata acacagcatc acccgcagag aaaaaccgat
     7381 tggttctctc ttctccttca tgagtggtat atgtatgcaa aataccggaa acaataatgt
     7441 acaagctctg ttctggcaat gtggcagaag caatcgtttc tcctttatcc agatacacca
     7501 tttccattcg agccaacagc tctttcactt ctctttcatc cacctgatac tcaaaacaga
     7561 gtttcttcaa ataagcttcc atacaaaata gattttagtt aatatatgtc acttaaaaac
     7621 acctaattcg acatagcagg catcattgtg cctctcaaat ataatttcct ttgggtatat
     7681 cgtaaatacc agatacagat caataatgaa acgaccgttg aaatgggtgg agcaaatccc
     7741 atgataaaca gcgacgagct atctatctgg ctgaaccagt atgacaacgg tatacggaac
     7801 aggaaagtgg ctatcagact gtgaatcatc gggaataacg agtttccttg tccgctgaaa
     7861 taagaattaa tgcagaacac gaaactaacc acgatgcagt cgatgctata ccctcgcaaa
     7921 taatctgccg ccattgccac cacagcagca tctttcgtaa agaaagcagt aagagtctcc
     7981 ggcaggaatt gcgaatacac gcaaaccgac acaccgaaaa caagagcaat cccaatcccc
     8041 gaagccagac atttattcat tctcttgata agtcccgctc catagttctg tgcagtcatg
     8101 gttgccacag ccgatgatat agccatcgga ggcagcatag caaacacgat gattttctca
     8161 acaacaccca gggaagcaga tgcaatgact cccatctgat tgacaatgac agtgataatc
     8221 agaaaagaaa cattgattaa agcatcctgc aaagcaatag gtgctcccaa caccaagatc
     8281 tttttagaca gattccggtt caatcgaata tctttccgtg aaaagtcaaa atggaatccg
     8341 tgccggtata agaaccagag cgctattcca aagctgactc cttgtgcagt tacagtagcg
     8401 atagccgctc ccgtagcccc ccaatggaaa taaccgacca atataaaatc gagcactata
     8461 tttatcacac atgccagccc aacaaaataa agtggtgttt tagaatcacc caatccacgc
     8521 aaaataccac atacaacatt atatcctact ataaacagaa tacccagaga gcataccaaa
     8581 atatagtttt tcgtatctac catcgcttcg acaggagtat gcatcagttc tgctatccga
     8641 ctatgaaaaa gcaccatgac caaagttagc actacgccgg ttattgaaaa caaccatacg
     8701 gaagacccga tagtaaaagc tacttttcga ttgtctttag ctccggtagc aatagcaatc
     8761 agcactgttg tcccggtagt aatacccaga ataatacctg taattgtctg catcacctga
     8821 ctaccaatag ctacggctgc cacacttgcc gaatcatcat attgtccgac aacgaaaagg
     8881 tcagctccgc cataaagtgc ctggagcaca ttggcaatca gaaaaggtac tgcaaactgc
     8941 aacaatacct tcggtacgct tccttgtgtc aaatctaact ctttcatagt ttcttcgata
     9001 cttttcctct ttatcttatt ttgttacaac aaaaaaaagt gccggacaag cgaatgattt
     9061 gcaccattca tcttatccag cactataatt attattatag caccctccga tgaggatttt
     9121 tatgcctgtc cctatttcag ggctgcaaat atgggctttg ttttcataat taccaaattt
     9181 taaccggttt ttattttctt atgaagatgt aactagctat atatcaacta ttatcagacg
     9241 aggtttggtc tataggatct ccgttagaaa aacgaaagaa agctgccaac cgatccggat
     9301 tcagcgtata acgtgcgcat tcttttaata agggttccgc attcattacg gcacaagaat
     9361 gagaaaccac ggacatcatc ggccagtcct ttaacgaatt tcctacaact aaagtgtgtt
     9421 cagaagctaa acccaaagcc ttacataact gaagcatccc ctctttttta ctcgcttcag
     9481 gatgaatgac tgttatcagc ggagctttat gaaagacctg gcagggattt tctttcaacc
     9541 gggtaagaat agattctctc tgttctttat cacgtaccaa tatactatac ttgtaaacca
     9601 ctccttcata actatgaata gtaacttttg acgattctcc atatacctcc ggatatactt
     9661 tcaccggcaa acacttaatc tgccgcgaat aagataataa acctccatct gcaaacactc
     9721 ctcccctgaa taaatcaaaa agagcctttc ccagcttttt cttcgcctgc tccatcgaca
     9781 gagaagtggc aagatataag gaaacggact gtgccatata tcgcaaagcg ttagcataac
     9841 tttctggaac ttttccctgt gaatcagtca gtgttccatc cacatcgaag aaaacagtcg
     9901 taataagtgg cttgtccggt attcgccaga atgccccttc tcccattatt cgatgtaaag
     9961 ggtgattgtt caggttacta aatgcaatat aacagtcaca aaccttcctc ttgcaagata
    10021 acggcacaac agctccatca ccttgataaa aattacctat cttcacccgg cttcggggac
    10081 aagcatacat atcccctttc caatcgataa aacaattatc ccttcctcct gcgcaaactt
    10141 cccattgtac cggagcattc ttcaagtcat actcaaaaag attatccagt tgactgaaaa
    10201 actgaatatc ttcctgactt aatggtgccc ttaacccttg catagcatta atgaataaat
    10261 aaatatccgg caaaagagca ttccgtaaat cattgagtac ggcctttgca gagggatttc
    10321 ctaccgctcc gacacatacc tgtattcccg catgatggag tatatgaatc tgatgcgcaa
    10381 atttctctac cgaagtcatc tcaggatgaa aactagccca aagccttatc ttacttatca
    10441 cagtgggagc cacacgaatc tcatcaagcc agtgtttagc cggaaaagaa aggttagtct
    10501 gacaggaaat tccggccacc tgtggcaatg ccgccaaatg caccattcct ttccgataat
    10561 aacgatggat caatacttca ccgtaaggaa taataaataa ctgcaacggc tcccctttcc
    10621 attgttcaat agctgctata aaacgattcc atgcctgttc atcctgtgtc gtatctgcca
    10681 gatgcgactt cttgccgaaa ggacaataag aacaggtata gttgcagcta ttcaatttgc
    10741 cgcgataata tatatgcctg aaggaaagta aagagctttc gttttccatt tctatttcgt
    10801 tcaataagaa taagtttcca tcagttctct tatttcagga gtaatgaaca actgaccaat
    10861 ataatcggag tatgccattc cgtcggaagt cagacaaata cgaccgttat ccgtattttc
    10921 tatccattgc cgttcagcta actgtcgaaa caacatcaca ttatccggtg attctccaaa
    10981 gcgacgctta tattcggcct tatcaagccc catataatac atcagatttt taatgatgaa
    11041 acgttgtcgc cgttcttcct gagaaagaat aaatccatta cgagccactg taaaatcagt
    11101 agtgcccata taatcatcta tctctccggc aatacaacgc tggcaaacag tataccgggt
    11161 ggcataatgc aaattaccca ggtaactgcg tccgccggag ccacacgaca gcatcacttc
    11221 atccccacat gagatttccg catcagtaga cggatgatga ataaaacgtc gcatcgacgt
    11281 ttgtagaaaa cctctgtctt tcaacaaatc acaagcggca caatacatct gaaaacagac
    11341 atcgtcggat tcccgctccg tgatagccgt tcccggtcgt acatatagcg gatagataaa
    11401 gagttcgtta ggctgaaaca gaagagcctg ttccaatgaa taaagaaagc tggccacagt
    11461 ttgtcctctg attccgtaaa tcaaatcaat attaaaaaac gggaattgtc tcttccgaat
    11521 agcctccagc gcctgattaa tcatgtctcg ccggggacgt cttttcaaag ctgttaattc
    11581 ttcgtcaagg aaactctgta cgccaatact cacacgagct actcctgctt gcttcaacaa
    11641 gtccaaacgg gtaggatcgg catattccgg cgatgtttct acggaagtaa aggtatgtga
    11701 aggatgcact ccgaataagg cagccgtatc caataggtat tccagttgag gaacagtgag
    11761 gagcaacggt gtgcctcctc caatggcgaa actatcaaat gccagtccgg tagtgagtgg
    11821 agacaactgt tgcgcctgct tgtgaagagt ttccaaataa gttgcgatat aatccgcacg
    11881 atttgtttgc agagaaaaca ggttgcaata tccacattta tgactacaaa aaggaatatg
    11941 gaaataaagc gatgctttct gtccttccac ctgtttcagg taaggaacca gcgaaaccgg
    12001 ggacggaaaa gaacgataag cagttttatg tggataacta tacatatagt ctacatatcg
    12061 tggtagcggt tgattcattt tttcgttaaa ataaagtgtt tgtaagggac tgtataaacc
    12121 gtttcgtgag atatgcaatg atattcatat ccatcctctc catagcaagt gccatgatcg
    12181 gaaagagcaa tcaccagcgt atttccccgc ttctgaaagg cctgaaataa acggggtagc
    12241 tgactgtcga catattgcag cgcggcagcg tgtgattcct tatcatcctt cattttgcct
    12301 tccacataat gacagttcgg ataatgaata gcagaaaaat tgatatacat aaaaatccgt
    12361 ttgtcctccg gatagttttc gagtttcttc aatgcaaaat caatttgttt ttcagtacta
    12421 tcgggtgccg tgcatccaaa ggtcggcagc caataacttt tagtaaagta accgggaaac
    12481 acacgcccca gttcattacg cttgctgaag aagttcaccc ctcctataca aatcgtttca
    12541 tagcctacat tggcaaggct ttgcacaaaa gttgcttccg taaacggata acttcccgca
    12601 ggcggaatac gtcccgtacc agcttgcaca gggaaaaaca accacttacg gctgcgtagc
    12661 gaatgaggtt ccgccggaga aggcagaaat cctgcaaaga tggcaaaatg agacgggtaa
    12721 gtaaaatttc ccggcgcatg tcttttttcc cattctcctc cgtgactgtt cagtaccggt
    12781 gttcttcctg cctcttcttc ctccttgctg acatcataac gcaaggtatc aaagcaaagc
    12841 atcaatatat catgagtacc caccacctga ttcatatcca gatccggatt ttgggtctgt
    12901 tcgccagccg gcagttcatc tatttgcatg gttatatctc ttttttatgt tttttatctg
    12961 ttgaatataa atagaattat gagcaaacat atcctgatac acatgatctc cctgtccgtt
    13021 gacttctatt atataaggaa tatctgttcc tctctctatc agtacatcca ctccggcata
    13081 ttgcaaatcc aaagattgaa ccgcttcctg acactgaaaa tagatttgtt gccgcactac
    13141 ttccggcaaa gacaattcgt tccaccaatg tgccttattg ttcagatgca gattggttat
    13201 gcttccttta ctgcatctca caacgatata atcaatttca gattcccggc acactacacg
    13261 aagatcataa ttctctccct gcaactgctc tttaggaatc cattcttcta aaatagcttc
    13321 tgtttgcatc acagcttccg ccaacgggat catctctttt tccgtactca aacggttgat
    13381 acgtttagtg ttatgaatga ctccatccac ttgttgcaag gtagtataga ctacccattt
    13441 attccggttg ggttgatagc gaacagccat aatacctccc gcccccgaac cgtaacgggg
    13501 tttcaaaaag catcctctac cgcaatcggc aagaagctct ctcaactcat caaaagaacg
    13561 gggagaaggt aacatcggag tcactttcaa ccctctgtcc atcaacactt gtttagtttc
    13621 ctttttatca agagcacgta ataaagcatg gggagtattc aaaaagcaca cgtcatcaga
    13681 tagcctcatc tcgcctaaac gttgcagtgt ctccttatat gcctgattca acagcgcata
    13741 tttcaggaaa ttcgtttcat cgcttacaca aggttccagt ttgataactg cctgccgtag
    13801 ttgcggcaag cagttaaaaa gttccccgta agtcataaaa cgaacttcca cctgcaagtg
    13861 tttgcctgct tcaataaagt attctatacg tttggacaga gagttgctga caacgattat
    13921 ctgcatctcc tattctgtaa tcatcgggta ataccacaat tcaccatcat attcatctgc
    13981 ctcttcagtt tcagcaatat ctattttcat agggagactc tgcaactgtt tcttcatctc
    14041 cttgctcaaa taattatagc gcatattgat aaacttcaaa tgagcgatct tatccatatt
    14101 atccagcaat aattgggcac cttcatcttt gagagtacca gccgaaacat ccattgtttc
    14161 aagttgggga agaatatccg actccaggaa catttctaca atcttgtcct gttcttcaga
    14221 gttgacgatc cccagataag tcagcttcgg gaaacgttct ttggagaaca acggacggaa
    14281 tatctcaata tcagcttcaa atccataatc ttccacacca acatatagaa tcagtttttc
    14341 cagattgggg aaatcagaac caagaatatc ttctaccact tcggtaggca ggccaccact
    14401 gataatttcg agtgaccgca actccggccg tgaagtcttt cccaaacgca gattattggt
    14461 tcctttgatt ttcagatctt tcaatttagg catggcatcg agcagcggac taatatcagc
    14521 ttgttcaatc catgaaatct cctgttcttc ctgctcaata tctccccaga acaagccttc
    14581 tatttgtgcg aacttctcct tattttcaat cattccctgt aataaggcag aacagtcgcc
    14641 accctcataa tcccaacaac cgattgttat ttgtttatat tcagagagat gtttatcttt
    14701 ca
//
