LOCUS       gnlProkkaIHPOLOGB_85    8645 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IHPOLOGB_85.
ACCESSION   gnlProkkaIHPOLOGB_85
VERSION     gnlProkkaIHPOLOGB_85
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 02:50:27
            Original ID  :: gnl|Prokka|IHPOLOGB_85
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 7461
            Orig. end    :: 16106
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8645
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:8205]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8205
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..8645
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8645
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(492..752)
                     /locus_tag="ctg85_9"
                     /transl_table=11
                     /translation="MKNVINMDITTKIKRSKLLYYVYYYVMSGLVNLYKLFLKPDGKLM
                     LFVCYGGRHYSDSTRVIYEAMLKDERFKDYIGLRQTDCCIY"
     CDS             complement(1077..2264)
                     /locus_tag="ctg85_10"
                     /transl_table=11
                     /translation="MEILNRKLSLLKGKVENSQPITIMIIGLGSVGCYLLDYLVSLGDS
                     QLRLVVVGRNAEKMQMDINIIRTASTIRHQCRSEIKVVDNCDLNDVNSIAAVLEAEKPD
                     FIVNSSRVYSGLKYGSISWSNLRAYGIWTPLSIRYAKNIMEAYDKANCEAISINTSYSD
                     AVIPWLKSAGKAYFDFGSGNLNHLVPRIKFYIAEKYGIKNFNDIDVTIAVSHFHDVVIS
                     KEGHAEGQDILLDIKFQGKDMDFNKEELLKSCSIAMPVDQKRNMMNASSNFDIIFSVLT
                     ALREEKQVKIHTPGVNGEIGGYPIIIDGVTATAKFDESVWTIDQMRKANRESIYCDGVE
                     NITDATLVYTDELVAKVKKSFNVDLPKSVKFVDIENVADLIINQIIKPQVLIFVQ"
     CDS             complement(2252..3259)
                     /locus_tag="ctg85_11"
                     /transl_table=11
                     /translation="MAVLERDYRIDGIKWLLIVLVTFGHVIEPALSNPIANKLYSIIYI
                     FHMPLFVFISGYYANVKDKEKLISKGFMLLETFLVVMIPQCFYYGSIIPLLNPENSGWY
                     LISLITWYIIFLLIINKLVGKIVVQYNGCGGQLLIFSCLLAVFAYMLPLKQFGNLLSFQ
                     RSCMFLPFFMMGFLRRVKGLPIIPDVSKCIKLVLAIASLVCFAFCLIYSGRILHVLEFN
                     NANVWHMSNLYNQNIGMLLVLKVLVYIGSIITTFAVLMFVNLPKSICAYGSKTLAYYVI
                     QGMFAHILSTYLQVNFYQALFLCVCILILTTVLLRFVDSKFITNPFSTLLKWKY"
     CDS             complement(3268..4008)
                     /locus_tag="ctg85_12"
                     /transl_table=11
                     /translation="MKYLIITVAGTATRFNRDTKEETLKCLYYTDEPQYALLAQLLKNC
                     GEYDKYILVGGYLYEKLGRFVKNELSGYGKKIELVYNEHFKDYGSGYSLYKGIEAIKEA
                     GDVTFVEGDLFFMATDFRQVYNSPKSVITINREPIYSNKAVALYINVDGKPRYLYDTNH
                     QTLTVSEPFKAIFNSGQMWKFSSSERLLKTVDSLTKEQLQGTNLEIIQAYFSDMNSEEY
                     DVVTFTDWFNCNTVADYDIVRKLM"
     CDS             complement(4005..5000)
                     /NRPS_PKS="Domain: NAD_binding_4 (83-198). E-value:
                     6.4e-10. Score: 30.4. Matches aSDomain:
                     nrpspksdomains_ctg85_13_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     143.1; E-value: 2.2e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg85_13"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.4e-09,
                     bitscore: 27.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.9e-09, bitscore:
                     25.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLYVISGVTGMTGSELSRQFVSQGHTVIGFDNFFASSIDTVKD
                     IIDNPSFIFYNYDINKVAQMDEVCDKAKELKIECDGRLVFINCAAVVHTKHFYEVESTF
                     QTNVLAMKDFLERAISMRADTYINCSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRT
                     SYACGKLMTEFFMKDAVGKGRIKGCSIRFANVYSRHERFAEHIIPHIIDNLLESHTVTL
                     LENSKVNKRTFLHNIDSCRAVMELIASEDALDGTVYNVATEEEIAIIDLVKTIAIKMGI
                     NDVDIRFEGYRKSDPERRLLNTDKIRTRTSWKPIITLDEGLTMCVNSIKK"
     aSDomain        complement(4407..4751)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg85_13_NAD_binding_4.1"
                     /evalue="6.40E-10"
                     /label="ctg85_13_NAD_binding_4.1"
                     /locus_tag="ctg85_13"
                     /protein_end="198"
                     /protein_start="83"
                     /score="30.4"
                     /tool="antismash"
                     /translation="VFINCAAVVHTKHFYEVESTFQTNVLAMKDFLERAISMRADTYIN
                     CSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRTSYACGKLMTEFFMKDAVGKGRIKG
                     CSIRFANVYSR"
     CDS             complement(5001..5729)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Metallophos_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_14"
                     /sec_met_domain="Metallophos_2 (E-value: 6.6e-28, bitscore:
                     88.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVILFADIHANLSAFEAVLADIEKHYQPDAMISLGDFIDYGMRS
                     NEIIERIQTVNIPLLANLKGNHEKALIDGELSCFSSERARVMSKYTRNHLTQTSIDYIS
                     NVMQEPMQELEIGGKKVLLLHGTIDDPYWGKLTPAKVEDEKYQDFDYVLSGHIHQPFKI
                     DVFFKVDNPIMRNQKRTTFINPGSVGQPRNQNPYAQYVYINFKTGETHFNAVPYDIEAE
                     QSLFPKEIDTFYSERLKFGI"
     CDS             complement(5733..6860)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 74.7;
                     E-value: 1.1e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_15"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.4e-20, bitscore:
                     63.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.5e-24, bitscore:
                     74.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRPEFFVNILKEQGIDFYAGVPDSLLKNICAYITDHLPAEQNII
                     AANEGGAMGIAVGYHLATGKVPVVYMQNSGEGNIINPFASLTDKDVYNIPVLLVIGWRG
                     RPGVHDEPQHVKQGKVTIGLLNTMGINYAILPKDEEGAAKQIKIAVDFMKATNECYALV
                     IEKDTFDTYKLQSVEVNELAMSREETIQKVASNIEDNACIVSTTGMISRELFEARTAWS
                     QGHERDFLTVGAMGHASQIALGIALQKPERRVYCFDGDGASIMHMGNMAITASMKCKNY
                     VHIVFNNGAHDSVGGQPTVGLKIDFCAIAQAVGYKAAYSVETMEALEAKLAEFKNAEGP
                     VFLQICVKKGNRKDLGRPTTTPIQNKEAFMEFLNK"
     CDS             complement(6895..8205)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 190.9;
                     E-value: 4.6e-58)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_16"
                     /sec_met_domain="CTP_transf_like (E-value: 1.7e-12,
                     bitscore: 37.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2e-114, bitscore:
                     371.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.2e-61, bitscore:
                     198.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTVYLGMIGDIMHPGYINIINKATEYGDVIIGLFTDKAIANHR
                     RLPYLTWEQRKNVVESIRNVSRVVPQDDWSYVSNLLKYKPDYIIHGDDWQVGPDKYIRD
                     EVFKVMEKLGGEVIEIPYTQNISASGIKQEIDALGVTPQMRLSSLRRLIAAKPIVRILE
                     SHNGLTGLIAEHTKVEVNGQEREFDGMWASSLTDSTSKGKPDIEAVDLTTRLHDLNDTL
                     EVTTKPVIFDGDTGGKIEHFGFTVRTLERLGISCVIIEDKVGLKQNSLFGTDAVQTQDT
                     IEGFQAKIRAGKEAQITRDFMIVSRCESLIAGKTVDDALERCHAYVEAGTDGIMIHSKE
                     KSGEDIKEFCLRFREKNAHTPIIVVPTTYNQFTEEELAEWGINVVIYANHMLRSAYPAM
                     VKCAETILYTSRSLEASEQYCMPIKQILNLIPGTKKK"
     CDS             complement(8230..8577)
                     /locus_tag="ctg85_17"
                     /transl_table=11
                     /translation="MLTVKYYVEKFILDMNTMKIIRVDEYRDKKKINRPAGSLFSVDGE
                     IYRVAQKCSRAYGESIFVYKTSKNFDFIKDKKVAELTGQSIVLSDGRKPILLHTYSQAG
                     GIEVIDYRCSL"
ORIGIN
        1 aacggacgca ctattcacat ttttcggctc tggaacaaaa cgtgaagcaa tactgccagt
       61 accaataatg ccaatattaa caataggacg cttctggcga agcaaagtag atgagacacc
      121 ctgagtgcga ggaaggtaaa tgactttaca gaactcattg agatagtcaa aatagccttc
      181 ccaatctgaa ccgattgcaa aaacatccac tccatatttc tgtatatcat caatcttctg
      241 cccacgatat tcttctatca caattgatct gcaagaccag tggatttaac cgcttcaata
      301 cgttccatca cgttattgca cgtgttcatc ttgcctctct ccaagtcgaa attatctgtg
      361 gtaacaccca caatgaggta atcacctaaa gctttcgcac gttttaagag gttataatgc
      421 ccctgatgaa acaaatcgta tgttcctaat aactttcttc ataaccttag ataaatcgct
      481 tttctcttaa atcaataaat gcagcaatca gtttgtcgta atcctatata gtccttgaaa
      541 cgttcatcct tcaacatggc ctcataaatc actcgcgtac tatcggaata atgacgtcca
      601 ccataacata caaaaagcat gagtttaccg tctggcttca agaacaactt gtacaaattt
      661 accaaacctg acattacgta atagtagacg taataaagta atttacttct ttttatcttt
      721 gttgtgatat ccatatttat tacatttttc atttgacaat cggagatata gaactgtaat
      781 tattttatta cgcgtatcct tataccactt atgaaaaata ttataggaac tttatgcttc
      841 atacaaaagg actggaggaa cttgacatga ggtaaagcct tggtctggta ctgaaaataa
      901 aaacttgcta aatcttcgct gctatacata tcttgctaat tttaatttac aacgaaggct
      961 aacatttcat tttgaacttt ttaaagtgct tacatagctg tgtatatcat aaaactataa
     1021 gttaaagatt atacagaaaa ttaacaacaa tctattatct gccattagtt tacaaattat
     1081 tgcacaaaaa taagcacttg aggtttaatt atctgattga taattaaatc tgctacattt
     1141 tcaatatcca caaactttac cgacttaggc aaatcaacat taaacgactt ctttacctta
     1201 gctacaagtt catcagtata gacgagagta gcgtcagtta tattctctac tccatcacaa
     1261 taaattgact cacggttagc tttacgcatc tggtctatag tccatacaga ctcatcaaac
     1321 ttggcagtag cagttactcc atcaataatt ataggataac caccaatttc accatttacc
     1381 ccaggagtat gtattttgac ttgtttttcc tctcgaagag cagtaagaac agagaatatg
     1441 atatcaaaat tactggaagc attcatcata ttgcgcttct gatctacagg cattgctata
     1501 gaacaggatt taagaagttc ttccttatta aaatccatat ccttgccttg aaactttata
     1561 tcaagcaaga tgtcctgacc ttctgcatga ccttccttag aaatgacaac atcatgaaaa
     1621 tgtgataccg caatagttac atcaatgtca ttaaaattct ttataccata tttctctgca
     1681 atatagaatt ttatacgagg cacaagatga ttcaaattac cactaccaaa gtcaaaataa
     1741 gccttacccg cagactttag ccaaggaata acagcatcgg aatatgaagt attgattgag
     1801 attgcctcac agttggcctt atcgtatgcc tccattatat tctttgcata tcgaatagaa
     1861 agcggagtcc aaatgccgta tgcacgaaga ttactccatg agatgctacc atacttcaaa
     1921 ccagagtaaa ctcgactact atttactatg aagtcaggct tttctgcttc aagtacagct
     1981 gcaatgctgt tcacatcgtt aaggtcgcag ttatcaacca ccttaatctc gctacggcac
     2041 tggtgacgaa tggttgaagc agtacgaata atatttatat ccatctgcat cttttcggca
     2101 ttacgtccta ccacaacaag acgaagttgt gaatcaccta gtgatacaag ataatccaac
     2161 aagtagcatc caacgctacc caaaccaata atcataatag ttattggctg actattttca
     2221 accttccctt tgagaaggga aagttttctg ttcagtattt ccattttaat aaagtagaaa
     2281 acgggtttgt aataaattta gaatcaacaa atcgtaatag aactgttgta aggattaata
     2341 tgcaaacaca gagaaacaag gcctggtaaa aattaacttg caaataggtt gataatatgt
     2401 gtgcaaacat gccttgtatt acataatatg ctaaagtctt tgatccataa gcacatatcg
     2461 acttggggag gttcacaaac attaaaacag cgaatgtagt aataattgat ccaatataaa
     2521 ccaatacttt caaaacaaga agcattccta tattttgatt gtacaaattt gacatgtgcc
     2581 acacattggc attattaaac tctaatacat gtagtatacg accactatag atgagacaaa
     2641 aagcaaaaca tactaaagag gctatagcca aaacaagctt tatgcatttt gaaacatcag
     2701 gaataatagg caggcctttt actcttctca agaaacccat cataaagaat ggtagaaaca
     2761 tacacgaccg ttggaacgat agcaggttac caaattgttt caacggaagc atgtatgcaa
     2821 atacggccaa caagcaactg aatatcaata actgcccccc gcacccatta tattgtacga
     2881 caattttgcc aactagctta ttgataatca acagaaaaat aatataccaa gttattaggc
     2941 tgattaaata ccagcctgag ttctccggat ttagtaaagg gatgatactt ccataataaa
     3001 aacattgagg aatcatcaca accaaaaatg tttccaaaag cataaaacct ttactaatca
     3061 gtttttcttt atccttaaca tttgcataat aaccactgat aaagacaaat aatggcatat
     3121 gaaaaatgta gattatagaa tagagcttat tggcaatagg attgcttaaa gcaggttcta
     3181 ttacatgacc gaatgtaact aatacaatga gcaaccactt tattccatct attctgtaat
     3241 ctctttctaa tacagccata ttcattttta catcaatttt cttacaatat cataatctgc
     3301 aacagtattg cagttgaacc agtcagtgaa agtcactaca tcatactctt cactattcat
     3361 atcactaaag taagcctgaa ttatttcaag attagtacct tgaagttgtt cttttgtaag
     3421 cgaatcaaca gtcttcaaaa gcctctcaga tgaagaaaat ttccacatct gaccactgtt
     3481 gaagattgcc ttgaatggct ctgatacagt taatgtctga tgattcgtat catataaata
     3541 ccttggtttg ccatcaacgt taatgtataa cgcaactgcc ttattcgagt agattggttc
     3601 tcggttaatg gtaatcacac tctttggcga attatacact tgcctgaaat ctgtagccat
     3661 aaagaacaag tcgccttcta cgaaagtcac atcacctgcc tcctttattg cctctatacc
     3721 tttgtataaa ctgtagccgg agccatagtc tttgaaatgc tcgttgtaaa caagttctat
     3781 ttttttgcca taaccagaga gttcgttctt tacaaatctt cccaacttct cataaaggta
     3841 gccccccaca aggatatatt tatcgtactc accacaattc ttcagcaatt gagcaagaag
     3901 agcgtattga ggttcatcgg tataatacaa gcatttgagg gtttcttcct tagtgtcgcg
     3961 attaaaacgc gtagccgttc cagcaacagt tataatcaaa tatttcattt cttgatacta
     4021 tttacacaca tcgtgaggcc ttcatcgaga gtgatgatag gtttccagct agtacgggta
     4081 cgaatcttgt ccgtattgag caatcgacgc tcaggatcag actttcggta accttcgaaa
     4141 cggatatcca catcgttgat gcccattttt attgcaatcg tcttgactag atcaataatg
     4201 gcaatttcct cttcagtagc cacattataa acagtaccat caagagcatc ctcagaagcg
     4261 atgagctcca taacggcacg acagctatca atattatgaa ggaaggtacg tttgttcacc
     4321 ttcgagtttt caagaagggt tacggtatgg ctttcaagca gattatcaat gatatgaggg
     4381 ataatgtgct ctgcaaaacg ctcgtgcctg ctatatacat tagcaaagcg aatagaacaa
     4441 cctttaattc gtcccttgcc aacagcatct ttcataaaga attcagtcat caacttgccg
     4501 caagcataac ttgtacgttg gctatgttcc gctgttgaca ttgccaaata atcagattct
     4561 ttcacaccgc cattctcatt ccaagactgc attgagtaaa cctccgaagt tgaacaatta
     4621 atgtaagtat cagccctcat agaaatggca cgctccaaga aatccttcat agcaaggacg
     4681 ttagtctgaa aagtactctc tacctcatag aaatgctttg tatggacaac agcagcacaa
     4741 ttgataaaca ccagacggcc atcgcactca attttgagtt ctttcgcctt atcgcatact
     4801 tcatccatct gagcgacttt gttaatgtcg taattataga agatgaacga gggattgtca
     4861 ataatgtctt taacggtatc aatagaactt gcaaagaagt tgtcgaaacc gattaccgta
     4921 tgaccctgag aaacaaactg acgagacagt tcactacccg tcatgccagt aacaccactt
     4981 attacatata agttcttcat ttatattcca aattttaatc gttcgctgta aaaagtatct
     5041 atctctttgg ggaaaagaga ttgttcagct tcaatatcgt aaggaactgc attgaaatgg
     5101 gtttcccccg ttttaaaatt gatatacaca tattgtgcat atggattctg attgcgaggt
     5161 tgtccaactg aacctgggtt gataaaagtc gtacgtttct gattgcgcat gattggattg
     5221 tcaactttga agaatacatc tatcttaaaa ggttgatgaa tgtgaccgct caatacgtag
     5281 tcaaaatcct gatacttttc atcttccact tttgctggag tcagttttcc ccaataggga
     5341 tcatcaatag ttccatgtaa aagaagtact ttcttaccac caatttccaa ctcttgcatt
     5401 ggctcttgca tcacattgct tatataatca atagatgtct gagtgagatg gtttcttgtg
     5461 tatttggaca tcacacgagc tctttctgaa gagaaacatg agagttcccc atcaatcaaa
     5521 gccttctcgt gattgccctt caaattggca agtaatggaa tattaacagt ttgtatacgt
     5581 tcaataattt catttgaacg cataccatag tcgataaagt cacctagact aatcatggca
     5641 tctggctgat agtgtttctc aatatcagct agaaccgcct caaaagcaga aagattggcg
     5701 tgtatatcag caaacagaat tactttcata ctttacttgt taagaaattc cataaaagcc
     5761 tctttgttct gaataggagt tgtagttgga cggccaaggt ccttgcggtt tccctttttt
     5821 acgcaaatct gaaggaaaac aggaccttct gcgttcttga attctgcaag ttttgcttca
     5881 agtgcctcca tagtttctac actataagca gccttgtagc ctacagcttg agcaattgca
     5941 caaaaatcaa tcttgagacc aacagtaggc tgaccaccaa cagaatcgtg tgcgccattg
     6001 ttgaacacaa tgtgcacata attcttgcat ttcatgctgg ctgtaatagc catattaccc
     6061 atgtgcatga tgctggctcc atcaccatca aaacaatata ctcgacgctc aggcttttgg
     6121 agagctatgc cgagagctat ctgggaagca tggcccatcg cccctacagt aaggaaatca
     6181 cgttcatgac cttggctcca agcagtacgt gcctcaaaga gctcgcgaga aatcatacca
     6241 gtagttgata cgatacaagc attatcttca atgtttgaag ccaccttctg aatcgtctct
     6301 tcgcgagaca ttgccagttc gtttacctca acgctctgaa gcttataggt atcgaaagta
     6361 tccttctcta tcacaagggc atagcactcg ttggttgcct tcatgaagtc gacagctatt
     6421 tttatctgct ttgcagctcc ctcttcatcc tttggcagaa tagcatagtt gatacccatg
     6481 gtattaagca aaccgattgt caccttacct tgcttcacat gctgaggttc atcgtgaact
     6541 ccagggcgcc ctctccaacc gataacgagg agcacaggaa tgttataaac gtccttgtcg
     6601 gtaagagagg caaacggatt aatgatattg ccttcaccag agttctgcat ataaactaca
     6661 ggcaccttac ctgttgccaa atgataacct acagcaatac ccatggcccc tccttcgtta
     6721 gcagcaataa tattctgctc agcaggaagg tggtcggtaa tatatgcaca aatgttcttg
     6781 agcaacgaat caggaacacc agcataaaag tctatacctt gttccttgag tatatttaca
     6841 aaaaattcgg gtcttaccat ttgtaaaata gtttaagggg taagaaatta atgtttactt
     6901 cttctttgtg cctggaataa gattaagaat ctgtttgata ggcatacagt actgctcaga
     6961 tgcttcaagc gaacggctag tatagaggat ggtttctgca catttaacca ttgcaggata
     7021 agcagaacga agcatgtgat tagcataaat cactacatta ataccccatt cagcaagttc
     7081 ctcttctgtg aactggttat aagtagtagg cacaacgatg ataggagtat gagcattctt
     7141 ctcgcgaaag cgcaagcaaa actccttgat gtcctctcca gacttctctt tggagtggat
     7201 cattataccg tcagtacctg cctctacgta agcatgacaa cgctccaaag catcatctac
     7261 agtcttacca gcaatgagag actcacaacg gctgacaatc atgaagtcac gagtaatttg
     7321 cgcttcctta cctgcacgaa ttttagcctg aaaaccttcg attgtatcct gagtctgtac
     7381 agcatcagta ccaaaaagtg aattctgttt taaacctacc ttatcttcaa ttataacgca
     7441 agagattccc aagcgctcaa gggtgcgaac ggtaaaaccg aagtgttcaa tcttgccacc
     7501 agtatcgcca tcgaagataa caggttttgt ggttacttca agggtatcat tgaggtcatg
     7561 gagacgggta gtcaaatcga cagcctcaat atcaggctta cccttagagg tagagtcggt
     7621 aagggaggaa gcccacatgc catcgaattc acgctcctga ccattcacct ctaccttagt
     7681 atgttctgct atgaggccag taagaccatt gtgactttca agaatacgta caatcggttt
     7741 agctgcaata aggcgacgga gagaagaaag acgcatctga ggagttacac caagagcatc
     7801 aatctcttgt ttgataccag aagcagagat gttttgggtg taaggaatct cgataacctc
     7861 accacccaac ttttccatta ctttgaatac ctcatcacgg atatacttgt caggacccac
     7921 ctgccaatca tcaccatgaa tgatgtaatc aggcttgtac ttaaggagat tagagacata
     7981 gctccaatca tcctgaggga ccacccttga tacgttcctg atgctctcaa caacgttctt
     8041 tctttgctcc caagtgagat aaggaagtct acggtggtta gcaatcgcct tatcagtgaa
     8101 caaaccgatt atcacatcgc catactcagt agctttgtta atgatgttaa tgtaacccgg
     8161 atgcatgata tcacctatca taccaagata aactgtcttt gccattatta tttaacattt
     8221 ttcaaattat tataaagagc atctatagtc aatcacctca atccctcctg cttgagaata
     8281 agtgtgcaac aaaatcggct ttctaccatc actcaggact atactctgac cagtgagttc
     8341 tgctaccttt ttatctttaa taaaatcaaa attcttactt gtcttataca caaagatcga
     8401 ctctccatat gcacgactgc atttttgtgc cactcgataa atttctccat ctacagagaa
     8461 taacgaacct gcgggacgat taatcttctt tttgtcgcga tactcgtcaa ccctaattat
     8521 cttcatcgta ttcatgtcaa gaataaactt ctcaacataa tacttaactg taagcactca
     8581 atttagggca tcccccttcg aaagggcact tttcagtgcc ctaaaccgag ttttgttaat
     8641 taatt
//
