LOCUS       gnlProkkaHDIOGKNB_1    12731 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HDIOGKNB_1.
ACCESSION   gnlProkkaHDIOGKNB_1
VERSION     gnlProkkaHDIOGKNB_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 11:04:52
            Original ID  :: gnl|Prokka|HDIOGKNB_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2218107
            Orig. end    :: 2230838
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12731
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7731]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7731
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12731
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12731
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="8"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(391..1728)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017:aldehyde dehydrogenase (Score: 303.3; E-value:
                     3.9e-92)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2116"
                     /sec_met_domain="Aldedh (E-value: 9.7e-100, bitscore:
                     332.2, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKVKDDIQRVFQLQKKQQKALRASTAEQRKEKLQRFLDSVIAH
                     EEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPEANGIL
                     MYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRDAFD
                     EKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGKSPTI
                     IDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTIVNAGFMEDDH
                     TPDRSKFTQIVNDRNFNRVKDLFDDAIEKGAEVVFGGVFDASDRTISPTVLKNVTPDMK
                     IMQEEIFAPILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHTTSGNAAI
                     NDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQASK"
     CDS             1871..3013
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 41.6; E-value: 3e-12)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2117"
                     /transl_table=11
                     /translation="MPESAEAQVKQALLALLEERDMQHITMKEIAERAKVSRGTLYLYY
                     EDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSVMM
                     NRGHFHRFFRDVFQQDVLLTPVHVNLTPIEREIYGHYRALYTYAIILYWLNEDAAAAPE
                     AISQKVWELVSQKRFYWLFGQAVPGEREKGKPIDRRVVRTREALQQAFLDVLAEKQDYA
                     GITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNELSFEEAE
                     EVLAGLLSALDRMPIVHLLNRDWVVPHVIPELLKALESFYLHQQTNIPAEKKLYAYYVS
                     AMIIGLILYRLDEGKAHAPEVLARKFLQFLDVKKYKVVLL"
     CDS             complement(3531..5000)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 70.2; E-value:
                     2.4e-21)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2118"
                     /transl_table=11
                     /translation="MKRNFFNLHDLKDSREFYESKPKPIGVFFTYILIALLIACIVFSF
                     YGKKEVILKTTADIQYTKPNSNVTNEVAGKVKTVDIKQVDKVKKGDTLLTLDNTEIQAQ
                     KRAVKADIKDLKEQAALNKTLKKSIENDKNLFSEDDHWGYQDQYLSYEKQSILLESSKE
                     NAKTQQKKLKKQKESIKDSLDKTKNKVKLKLQRISDLQDSIKNNKSFAKQDDKYSSYYN
                     SYQTNKQNVEQQLDDLRKMKDELDKNRFSQQKENLNGQLESLKQDMLVKLSEEKDELNQ
                     SLDEINSSIKSDDSDSDSDNSEETNYKLSIEQLKTNLLNQTSQKQTDLQTTLKSKEDDL
                     KMIDLQLEKYKIKAASDGYVNVLTNISPGDNLQAGTAILTIIPDKEKLKANIYIPSHEI
                     TNINEKDEVRFHIENTNQTIKGVITKISPDSISDQNGQKFYIAESTIEKNKVMNDNGST
                     LHLKNGMQTDVSIIVDSKRYIDYLLEILHLQ"
     CDS             complement(5001..7184)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 289.2; E-value:
                     1.1e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2119"
                     /sec_met_domain="Peptidase_C39 (E-value: 1e-44, bitscore:
                     149.5, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 4.1e-237, bitscore:
                     787.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFFKKYQYVKQIDEKDCGAACLATILKHYGSKLSINKIRDIAGTD
                     KQGTSALGLVRAAEQLGFSAKGVKADKTALEEPFTLPAIAHIILNGQLLHYVVIHKITK
                     DQIIIADPGRGIIKYTKKEFLEVWTGILILLTPSETYKIHVETSTIRSDIFKLILHQKS
                     LIIHTILASFIITVFGIMGTFYFQTVIDEILPNRLNSTLHILSFGLIIMYLFKVLLTAF
                     RQYLMILLGQKLSISIMFGYFKHVLSLPMKFFSTRKIGEIISRFNDASKVIDAIISASL
                     SVVLDTVMLVMVGIFLYLQNTTLFLITLAFIPFYVLTVWFFMKPYESINNTEMENNAQL
                     TSKIVETLNGIETIKAYNAEYMMSYETEKRFVKYLRSAFKHGVIDNLQNSIKMFLDLAS
                     GAFILWIGSTQVMKGTLSIGQLITYNALLTYFLNPLQNIIGLQSKLQSASVASKRLGEI
                     LEVEHEIKDKDAQITTPGSINGPIEFIKINFRYGTRRLILKDITLRIDKGEKVAFIGES
                     GSGKSTLTKLLMKFYTAESGDILINGYHINDIHAHSLRESISYIPQESHFIQGSIFENL
                     LLGNSGSFTFEEIIEVCKQTNVHDFVNDLPMRYDTLVEENGSNLSGGQKQRLAIARALL
                     RKPNILIMDESTSNLDTTTEQGISKMIYDQTVGITTIIIAHRLSTIMNCDKIFVMENGE
                     IIEYGNHNDLLKKKGKYYELWENQMPSRGMVTI"
     CDS             complement(7265..7510)
                     /locus_tag="ctg1_2120"
                     /transl_table=11
                     /translation="MNNLENKSFEVLSDNQLELVEGGSGYGDGVAGGLTGGAILGGVVK
                     GAQNGAKYGRLGGAWGVAAGVVVGGAIGGYLGYKGA"
     CDS             complement(7534..7731)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2121"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.9e-13,
                     bitscore: 47.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKELSNLELEKVEGGNWQNVTKNTLFAAADGAAIGGMFGGPAGAF
                     VGAHYGAAAYAIGYALDHRK"
     CDS             complement(8033..8842)
                     /NRPS_PKS="Domain: PKS_KR (7-160). E-value: 2.5e-09. Score:
                     29.1. Matches aSDomain: nrpspksdomains_ctg1_2122_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     247.6; E-value: 2.2e-75)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2122"
                     /sec_met_domain="adh_short (E-value: 1.3e-31, bitscore:
                     107.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 6.3e-36, bitscore:
                     122.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQMEE
                     TVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHEYP
                     VDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKGGIT
                     NLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEKFREANKWVTPLGRLG
                     QPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIDEKWK"
     aSDomain        complement(8363..8821)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_2122_PKS_KR.1"
                     /evalue="2.50E-09"
                     /label="ctg1_2122_PKS_KR.1"
                     /locus_tag="ctg1_2122"
                     /protein_end="160"
                     /protein_start="7"
                     /score="29.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TAVITGAATGIGQATAEVFANEGARVIIGDINKDQMEETVDAIRK
                     NGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHEYPVDLFDRI
                     IAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG"
     CDS_motif       complement(8738..8815)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_2122_0001"
                     /evalue="1.80E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1_2122"
                     /protein_end="35"
                     /protein_start="9"
                     /score="17.4"
                     /tool="antismash"
                     /translation="VITGAATGIGQATAEVFANEGARVII"
     CDS             8959..9210
                     /locus_tag="ctg1_2123"
                     /transl_table=11
                     /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFLN
                     ASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG"
     CDS             9378..11258
                     /locus_tag="ctg1_2124"
                     /transl_table=11
                     /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYY
                     KALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAFKK
                     ENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPCEKD
                     SVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENE
                     FEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNA
                     ILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSEDLSLNIS
                     REMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANK
                     DQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQTEMVADKGY
                     EILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESKYKDLFEEMK
                     NILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAEKVLEINPNHE
                     VFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKVMV"
     CDS             complement(11300..12685)
                     /gene_functions="transport (smcogs) SMCOG1169:sugar
                     transport protein (Score: 439.1; E-value: 2.9e-133)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2125"
                     /transl_table=11
                     /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTLT
                     EGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIASR
                     VILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFEAWR
                     WMVGLAAVPAVLLLIGIAFMPESPRWLVKRGREEEARRIMNITHDPQDIEMELAEMKQG
                     EAEKKETTLSVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGTSASAL
                     GTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLSASTAWM
                     TVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVSLVFPLML
                     SAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKSTQNQVLNE
                     RTL"
ORIGIN
        1 agtaaagaat agcgaaaata aatatgatgg ccaaaacagg gattgttcca atgatcaaca
       61 tgaaaaactc atattgggct tctgacatgt gtgtacctgc cgcatcaatg agtggcaaca
      121 caatgaaggt gttaatgaaa atcataatga aagagaatat agctataata aatacatcaa
      181 taatagaggc ggctgcccga atccaaaatc ctgctggttt ttccatgtat cattttactc
      241 ctttgaagtt ttctgggata ttatacgtta gaggctgcag ggtttggtct cgtagtaaaa
      301 atggtatttt atcactttta atctctttat ttaggtgata taaagataaa aaaagaacct
      361 gcaagatgat gcagattctc ttcgttacga ttatttggag gcttgaataa atacaccctt
      421 ctcatgagaa aactctttga atccgtatac cccatgatag gagccgattc cgcttgtgtt
      481 tacgccgccg aatggcaggt tgacgtcact gaaatggacg acgacatcat tgatggcggc
      541 atttcctgat gtcgtgtgct gaaggacgtt gtcaatcagg tcttggtttt tgctgaacac
      601 ataaagcgca agcggtttat cgcgatcatt tacgtaatcg atgacctcgt cgatgtcttc
      661 ataattcatc attggcagga tcggtgcgaa gatttcctcc tgcatgattt tcatatcagg
      721 cgtgacgttt ttcaaaacgg ttggcgagat cgtgcggtca ctggcatcaa atacgccgcc
      781 gaacaccact tccgcccctt tttcgatggc atcgtcgaac aggtctttga cgcggttgaa
      841 gttgcggtca ttgacgattt gcgtaaattt gctgcggtct ggggtgtgat catcctccat
      901 aaatcctgcg ttgacaattg tttgtaaaat gcccgcgaac ctgtcctgaa cgtctttttt
      961 aatgaacagg taatcaggtg cgatgcaggt ttggccggcg tttacgaatt tgccgacggc
     1021 gatttttttc gctgcgtcca tgagatcgta ttcgctgtcg ataatcgttg ggcttttgcc
     1081 gccaagctca agtgtgacag atgccaagtg tttggccgcc gctgtcatga cgattttccc
     1141 gacatttgtg cttccagtga agaaaatatg gtcaaacggc tgatcaagaa gctcggttgc
     1201 cacctcaacc tctccttcaa aaatcgcgac ttctttttca tcaaacgcgt ctcttatcac
     1261 tttagcggca atgttgcttg tgttcatcgt gaaatcggac agcttcacaa tcgcgctgtt
     1321 tccggctgcg agagaagcgg caagcggcgc catcgtcagc ataaacggat agttccacgg
     1381 gccgaggatg agtgtgacgc ctttaggctc gtacataaga atcccgtttg cctcagggct
     1441 taacgatgaa ccgacttcct taggcgccat ccattgttcc aggttgttca tattatctct
     1501 gatcgctttt ttcgttcctt cgatttccgc ttttttgacc tcgtgatatg gtttgcggac
     1561 gtctttgcgg atcgcttcaa tgatttcttc ctcatgggcg atgacggaat ctaaaaagcg
     1621 ctgaagcttc tctttgcgct gttccgctgt tgaagcacgc aaggcttttt gctgtttttt
     1681 ctgaagctga aagacacgct ggatgtcgtc ctttactttc tgttccattg taagatcccc
     1741 ctcatttgct ttcttctttt ctcggaccta ttataaggtg gtaccttttt tataagaaag
     1801 acaacggtga accatctata cgttaccgta catatattga acaactgtct aatgattgga
     1861 ggtgtctttt gtgccggaat ctgccgaagc tcaagtgaaa caggcgctgc tggctttatt
     1921 ggaagaaaga gatatgcaac atatcacaat gaaagaaatc gctgaaaggg ccaaagtgag
     1981 ccgtgggacg ctctaccttt attatgagga taagttttca atcattgagg atgtgatcga
     2041 agacatgaag gaaggactgg gcaaagcgct ttttgacgcc ttcagtcata tggataccct
     2101 tcatttgaac aaaaaacggc aaacggtgca tccgacgctg tcctttgttc atgagcatcg
     2161 atcctttttt tctgtgatga tgaacagagg gcatttccat cgttttttta gggatgtgtt
     2221 tcagcaggat gtgctgctga ctccggtcca tgtgaatttg acgccgatcg aacgagaaat
     2281 ttacggacat taccgggcct tgtacacata cgcaattatc ctgtattggc tgaatgagga
     2341 tgcggccgcg gctccggaag ctatcagcca aaaggtatgg gagcttgttt ctcaaaagag
     2401 attttattgg ctgtttggac aagctgtgcc aggagagcga gagaagggca agccaatcga
     2461 caggcgggtg gttcgaacga gagaggcgct ccagcaggca tttctggacg tattggcgga
     2521 gaaacaagac tacgcgggca tcacgatttc ggatattacg cgtaaaagca atatccgccg
     2581 cgcaactttt tatgatcact atgccaataa agaggaattg ctccaaacca tgatacagcg
     2641 atcatgtgcg gagatcattg atcacctgac gattgcctca agtccgaatg agctttcctt
     2701 cgaagaagcg gaggaggtgc tcgccggcct gctttctgct ttagaccgca tgcctattgt
     2761 ccatttgctc aatcgggact gggttgttcc tcatgtgata cccgagttgc tcaaagcgtt
     2821 ggaatcattt tatctgcatc agcaaactaa tattcctgcg gagaaaaagc tttatgccta
     2881 ttatgtatcg gcgatgatta tcgggctgat attgtatcga ctcgatgaag ggaaggcgca
     2941 tgcgccggaa gtgctggcga ggaagttttt gcagtttttg gatgtgaaga agtataaggt
     3001 tgtattgcta taaacgagag aaaccagcca gtggctgaaa tggaaggccg gagagtaact
     3061 tcagtatgtt atgaaaagaa aacctaagag aggtaacgtt tacaggatat aaatttgccc
     3121 ggatagtcag tccgggcttt gtgtcgttat gtcacttggt cttgtgagtt tctttctttt
     3181 ctttcaaagt gaaatttaaa aatagaaggg ctaaaagaat tagcgcaatg ttcaccgacc
     3241 aagatttcca gcttgaagta ggatctaaaa tcgtattgaa gagcaagtga ataatagaag
     3301 aaaatgaaaa gagtaaaaat aatagtttgt tttgcgacat aaattgcttg acctttctgt
     3361 tgaaaattta gttgtaatta tagcataatt acataaaaca agaaataaat ccacaaaaat
     3421 gaaattgcat aatagtttat tttgagtggt tcacttattc taagtacatt atttcagacc
     3481 ggtgagtaac ccataaacag attgcctctg ttggatttat atttattata ttattgtaaa
     3541 tgtagtattt ctagtagata atcaatgtac cttttagaat ccactataat tgatacatcg
     3601 gtctgcattc cattttttaa gtgtaaagtt gatccgttat cgttcataac tttatttttc
     3661 tctattgtgc tttcagcaat ataaaatttt tgtccgtttt gatcactaat actgtctgga
     3721 cttatttttg taatgacacc tttgatggtt tgatttgtat tttcaatatg gaatcttact
     3781 tcatcttttt cattaatatt tgtgatctca tgactcggaa tataaatatt agctttaagc
     3841 ttctctttat cagggataat agtcaaaata gcagtgcctg cttgtaaatt gtcacctgga
     3901 gatatatttg ttagtacatt aacatagccg tcacttgctg cttttatttt atatttttct
     3961 aattgtaaat ctatcatctt tagatcatcc tcttttgatt taagagtggt ctgaagatct
     4021 gtttgctttt gagatgtctg atttagcaag tttgttttga gctgttcaat agaaagctta
     4081 taatttgttt cctctgagtt atcggaatca ctgtcagaat cgtcactttt aattgaactg
     4141 ttaatctcat caagagattg atttaattcg tctttttctt cacttagttt tactaacata
     4201 tcttgtttta aactttcaag ctgtccgttc aagttctctt tctgctgtga aaaacggttt
     4261 ttatcgagct catctttcat cttccgtaga tcatcaagct gctgctctac attttgtttg
     4321 ttagtttgat aactattata gtaagaactg tacttatcat cctgtttggc aaaggattta
     4381 ttgtttttaa tggagtcttg cagatcagaa attctttgaa gctttagttt gactttgttt
     4441 tttgtcttat ccagactatc ttttatgctt tctttctgct tcttaagttt tttctgctga
     4501 gtttttgcat tttcttttga tgactctaac aaaatacttt gtttttcgta cgagagatat
     4561 tgatcttgat aaccccaatg atcgtcctca ctgaataaat ttttgtcatt ttcaatactt
     4621 ttttttagag ttttgtttaa cgcagcttgt tcttttaaat ctttgatatc tgctttaaca
     4681 gctcttttct gcgcttggat ttccgtattg tctagagtta atagagtatc tccctttttc
     4741 accttatcaa cctgtttaat gtcaactgtt tttactttgc cggctacttc gtttgttacg
     4801 ttgctgttag gctttgtata ttggatgtca gctgtcgttt ttagaatcac ttctttcttt
     4861 ccatagaaac taaaaacaat acatgcaata agtaaagcta tcagtatata tgtaaagaaa
     4921 acaccaattg gtttgggttt tgattcatag aattctctgc tatccttcaa atcatgtaaa
     4981 ttgaaaaagt tacgtttcat ctaaatagtc accatccctc tggatggcat ttggttctcc
     5041 cacaactcat agtacttgcc ttttttcttc aataaatcat tgtggttccc atactctatg
     5101 atttctccat tttccatgac aaatattttg tcacaattca taattgtact caaacggtga
     5161 gcgattataa tcgtagttat accaacagtc tgatcgtata tcatttttga tattccctgt
     5221 tcggtagtcg tatcgagatt gcttgttgat tcatccatta tgagaatgtt aggttttctt
     5281 aataatgctc tggcaattgc gagtctttgc ttctggcctc cagataaatt agacccgttt
     5341 tcctctacga gagtatcgta tctcattggt aaatcattga caaaatcgtg tacatttgtt
     5401 tgtttgcata cttctataat ctcttcaaag gtaaaactgc ctgagttacc gagcagaagg
     5461 ttttcaaaaa tggaaccctg tataaagtga gattcttgag ggatataact tatactttct
     5521 cttaatgaat gagcatgaat atcattgata tgataaccat taattaaaat atcaccagac
     5581 tcagctgtat aaaatttcat taagagctta gttagagtag attttccgga accgctctct
     5641 ccaataaaag cgactttctc ccctttatct atacgtagtg taatatcttt taggattagt
     5701 cgccgagtac catatcgaaa gttaatttta ataaattcaa ttgggccatt aatagaccct
     5761 ggcgttgtta tttgagcatc cttatctttt atttcgtgtt ctacttctag tatttctccc
     5821 agtcgtttag aagcaacaga agctgactgg agtttcgatt gaaggcctat tatgttctgt
     5881 aaaggattca aaaaatatgt taacaatgca ttgtatgtaa tgagctgacc tattgaaaga
     5941 gttcctttca tcacttgagt tgaaccaatc cacaatatga atgctccact tgctaaatcc
     6001 aaaaacattt taatagaatt ttgaagatta tcgataactc catgcttaaa agcagagcgc
     6061 aaatatttca caaatctctt ttctgtctca tatgacatca tatattcagc attatatgct
     6121 ttaattgttt caataccgtt aagtgtctca actatttttg aagtcagctg agcattgttt
     6181 tccatttcag tattgttgat ggattcatat ggcttcataa aaaaccaaac tgtaagaaca
     6241 taaaatggga taaaagccaa tgtaattaaa aataaagttg tattttgtag atataaaaag
     6301 atgcctacca ttacaagcat tactgtatca agtactactg atagagaggc gctaataata
     6361 gcatcaatta ctttgctagc atcattaaat ctagatataa tctccccgat ctttctagtg
     6421 ctaaaaaact tcatcggtaa gctaagtaca tgtttgaaat aaccaaacat tattgaaata
     6481 cttaattttt ggcccaataa tatcattaaa tattgcctaa aggctgttaa aaggacttta
     6541 aataagtaca taatgatgag gccgaatgaa agtatatgta acgtgctatt caatctattt
     6601 ggtaaaatct catcaatgac cgtttgaaaa taaaaagtcc ccataatacc gaaaactgta
     6661 atgataaagg atgctaaaat tgtgtggatg atcaatgatt tttgatgaag tattaatttg
     6721 aatatatcac ttcgtatagt actggtctct acatggatct tatatgtttc agaaggagtc
     6781 agtaaaatta agattcctgt ccaaacctct aaaaattctt tttttgtgta cttaatgatt
     6841 ccgcggccag gatctgcaat gataatctgg tcttttgtaa ttttatgaat aacaacataa
     6901 tgtaataatt gtccattaag aatgatatgt gcaatagccg gcagtgtaaa gggttcttct
     6961 aaagctgttt tgtcagcttt tactcctttt gctgaaaagc ctaattgttc agctgctctg
     7021 actagtccaa gtgcgcttgt gccttgttta tctgttcccg caatatctcg aattttattt
     7081 attgataatt tggagccgta atgcttcaat atagtggcta gacaagctgc tccacagtct
     7141 ttttcatcaa tttgttttac atattggtac tttttaaaga acatctaaat actccatgat
     7201 tctaattatt ttaaaaagaa agacaatctg ttaatcaaac agatcgtctt aagttaaggg
     7261 atttttaagc ccctttatat cctaagtaac caccgatggc tcctccaact acaacaccag
     7321 cggcaactcc ccatgctcca cctagtcttc catatttcgc gccattttgg gcccctttta
     7381 ctacaccgcc tagtatagct cctcctgtga gtcctccagc tacaccatca ccatagcctg
     7441 aacccccttc tactaactca agctgattat cagataagac ttcaaaactt ttattttcta
     7501 aattattcat atgtatattc ccctaacatt gtattatttt ctgtgatcca aagcgtaacc
     7561 aatagcgtat gcagcagctc cataatgagc cccaacaaaa gcgcccgctg gaccaccaaa
     7621 cattcctccg attgcagctc catcagcagc agcaaataga gtattcttcg taacattttg
     7681 ccagtttccg ccttccactt tttctaattc taaattagat aattctttca taaataaccc
     7741 tccttttgta ctggtttcct agttattcta gtataaatta ttggtaaaat caatatcatt
     7801 tactatattt ttctttggta attaacttac ttttagatga tgaagatgtt ggagtttatt
     7861 taatttcttt tggacaaacg acttgacttt aaatgtatat tcaagaggat aaattggatt
     7921 attactataa tgttctaata atctactgta taagattttt gaaatgctaa tcctaaattc
     7981 aataaaagag ggcagatttc tatccaccct ctcttaatga atcatctgaa ttttatttcc
     8041 acttctcatc aatcagcatc ttcccaggcc atgtatatgc catgatgccg ccgtctgcgg
     8101 tgatgtcctc tcctgtgacg tatgagctgt cgtctgacgc gaggaacagg gccactgtcg
     8161 ccatttcctt cggctggccg aggcggccga gcggcgtgac ccatttgttg gcttcgcgga
     8221 atttttcacc catttcctgt tctttggtgc ctgctaattt gtcaatcagc ggggtttcga
     8281 tcgtacccgg tgaaatggaa ttgacgcgga tgccgttccg tgcgtagtcg atcgccatcg
     8341 cttttgtcag gttggtgatg ccgccttttg ctgcgttgta gcccgagcgg tcaaggtccg
     8401 cggcacggcc tgacatggag gaggtgttga tgatggagcc tccattttcg agcatgagcg
     8461 gaatcagata tttgctgcaa aggaatgtgc cgcgcaggtc gacagcgata atgcggtcaa
     8521 acaggtcaac cggatattcg tgcacctttc cgccttcctg atcaacgccg gcattattaa
     8581 acagaatatc aatcgttccg catgcatcct tgatttgatc agcaaatgct ttcacactgt
     8641 tttcatctga cacatcgagg tgaaaggatt cggcctgtcc tccgtttttt ctgattgcgt
     8701 caactgtttc ttccatttga tctttattga tatctccgat gatcacacgc gcgccttcat
     8761 tggcaaaaac ctctgccgtc gcttgcccaa tgcctgtcgc ggcgcctgtg atcactgctg
     8821 ttttgttttc aagtcttccc atgatacgag acctcctttt tctatttgtc ttcccgctat
     8881 gtgcagtgat aaacatgcga gaaaagaaag gccagcatat gttaagatga attagaaatt
     8941 gttgggaggt ttgtatgttt gaaggtacag cataagaagg agctcaagtt ttattgcatc
     9001 gtgaccattc catctgcatt tgttgtgctg actgtcatct cttttttatt gcaagagatt
     9061 acgtttccgg tgactgcaag cgcatttctg aatgcttcat ggcataatct tttgtttttg
     9121 ataccgttcg gtttgttttt ctacccggtg catatttgga tgaagcggga gtttggccgc
     9181 tggaatgaca cagaaaaaaa gagaggatga tgaagcctct cttttttatg agaatgagtg
     9241 agaaaaagag tgaaaacaaa tccaactaat gttaaattta catatatatg catctatcaa
     9301 tctaattgac aattgtcatc ttatgtgata aatagatgct gaaaagggtt tacataatgg
     9361 taaaggagcg atcaagagtg gcgaaaaaag agtttaaagc agagtctaaa cgcttgctgg
     9421 atatgatgat taactccatt tatacccaaa aagaaatttt cctgcgcgag ttaatctcca
     9481 attcgagtga tgcgattgac aaaatctatt acaaagcgct tacggacgat gcgcttacgt
     9541 ttgataaaga tagttactac ataaaggtcg cagctgacaa agatgcgaga acattaacca
     9601 tctctgatac ggggatcgga atgacaaagg atgagcttga acagcatctt ggaacaattg
     9661 caaaaagcgg ttccctcgcg tttaaaaagg aaaacgagct gaaagacgga catgacatta
     9721 tcgggcagtt cggtgttggt ttttacgcgg catttatggt tgccgatgtc gtgacagtca
     9781 tcagtaaagc gcttggcagc gaagaggctt ataaatggga gtctgcgggt gcagacggct
     9841 atacgattga gccgtgtgaa aaggattctg tcggtacaga cattatcctg aaaatcaaag
     9901 agaacacaga agatgacagc tatgacgagt ttttagagga atatcgttta aaagcgatca
     9961 ttaagaagta ctccgacttc attcgctatc cgatcaaaat ggataccacc attaataagc
    10021 cgaaggaagg cagcgaaaat gaatttgaag aggtgcagga agagcagacg gtcaacagca
    10081 tggtgccgat ctggagaaaa aacaaaagcg agctgacaga tgaggattat gaaaaattct
    10141 atgctgaaaa gcattacggg tttgataaac cgctgacaca cgttcatatc agcgtggatg
    10201 gagcggttcg ctacaacgcg attctattcg tccctgaaaa catgccgttt gactactatt
    10261 ccaaggaata tgagaaaggc ttggagctgt attccaatgg cgtgctgatc atgaataagt
    10321 gcgcagacct gctaccggac cacttcagct ttgtgaaggg catggtcgat tctgaggatc
    10381 tgtcgctgaa tatttccaga gaaatgctgc agcatgaccg ccagctgaag ctgatcgcga
    10441 aaaacatcag caagaaaatc aaaagcgagc tgcaaagcct gttgaaaaaa gaccgcgaga
    10501 aatacgagac gttctacaag tcgttcggca gacagctgaa attcggcgtg tacaatgatt
    10561 ttggcgcgaa taaggatcaa ttgaaggatc tcctcttatt ctactcttca aaagagaaaa
    10621 aactggtcag cttagacgag tatgtttcca gaatgccaga ggagcagaaa ttcatttatt
    10681 acgcgaccgg tgattcttac gaccgcattg agaaactgcc gcaaacggaa atggtggcgg
    10741 acaaaggcta tgaaatcctc tactttactg aggacatcga tgagtttgca attaaaatgc
    10801 tggcttctta tcaggaaaaa gaattcaagt ccgtatcaag cggagacctt ggcatagaca
    10861 cggatgagga tcaaaagcag tccgaggaag aggaaagcaa gtataaggat ctgtttgagg
    10921 aaatgaaaaa cattctgtca gacaaagtga aaaacgtcag aatctcaaaa cggcttaaat
    10981 cacatccagt ctgccttgct gctgacggcg aagtgacaat tgagatggaa aaaatcttaa
    11041 atgcgatgcc tgacagccaa aatgtgaagg cggaaaaagt gctggaaatc aacccaaatc
    11101 acgaggtatt ccaaacactg caggacgcgt ttgaacaaga taaagagaag ctgagcctgt
    11161 acacaaacct tctgtacaat caggcgctcc tcatcgaagg cctgccgatt caggaccctg
    11221 tggaatttac gaacaatatt tgcaaggtca tggtgtaaac agaaaaagga atcgtctcat
    11281 aaggagacga ttcctttttt tataatgtac gctcattcag cacttggttt tgggtgcttt
    11341 tcttcttttt aaaccgtttt ttcaggcttg cttcaatttc ctccaagctt ttccctttgg
    11401 tttccggtac catgtagaac gcgaagaaaa atgagagaag acaaatgact gagaaaacca
    11461 taaagaccca tgcgatgccc atcgcgctta gcatcagcgg gaagacaagc gatacgatca
    11521 ggttagccgc cgataacacc aaagtcgtga accctgtcgc ggctccgcgt gctttggacg
    11581 ggaagagctc aggcatgagc acccacacta ccggacccca tgtcgcctgg taaaagacga
    11641 tatagacacc tagaaagact actgtcatcc acgctgtaga tgcggaaagc cccagtgtca
    11701 ggagcacgcc tgataaagca gcaaggctca gtgtgatgcc gacacttccc cagatcagaa
    11761 gttttttgcg gccgacacgg tcaattaaga tcatggcagt gatacacatg atgacgttga
    11821 ggatgccgat ccccattgtg ccgagcgccg aagctgatgt gccaagaccg gccttcgtaa
    11881 aaatggttgg cgcgtagtag atgaccgtgt taatgccgac cgcctgctgg aaaatggcaa
    11941 ggccgacgcc aatcagaagc atggggcgaa tccatttggc tttcaacacg ctgagtgtcg
    12001 tttctttttt ctccgcttcc ccttgcttca tctctgccaa ttccatttcg atgtcttggg
    12061 gatcatgagt gatgttcatg atgcgtctcg cttcttcttc gcggccgcgc ttcacgagcc
    12121 atcttggcga ttccggcatg aacgcgatgc cgattaatag aagcacggca ggcactgcag
    12181 ccagaccgac catccagcgc cacgcttcaa acggtgtgaa caggtagtta acgatatagg
    12241 cgagcaaaat cccggtgaca atcattaagt tgttcattgt gccgagtgtc ccgcgaattt
    12301 tcgtcggtgc catttcggaa agatacacgg gcacaagtgc cgttgaaccg ccgacggcca
    12361 acccgagtat caccctagat gcaatcagca tgccgattgt ttgagaaaat gcgcaagcga
    12421 gcgcgccgat aataaaaatg atggaaagga caaatacaac ctttctcctg ccccagcggt
    12481 ctgagcatgt gccgctcaag gcagaaccga aaatcgcgcc aaggagcagc atgctgacaa
    12541 ccaatccttc tgtcaatgtc gttaaaggaa tatcgttatt gataaacagg agtgctccgg
    12601 agataacacc tgtatcgtaa ccatatagca gtccccctaa agcgccgaaa aagtagatca
    12661 tatatttcct tgtgtctttc ttcacaaatg tctcctcctc agttgttgag ccaatgagta
    12721 tctaaaatgt a
//
