LOCUS       gnlProkkaOMKNHDFD_193  13686 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMKNHDFD_193.
ACCESSION   gnlProkkaOMKNHDFD_193
VERSION     gnlProkkaOMKNHDFD_193
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 06:41:20
            Original ID  :: gnl|Prokka|OMKNHDFD_193
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13686
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..90
                     /locus_tag="ctg193_1"
                     /transl_table=11
                     /translation="MNIQICNIIVLRKKRTDIWLKVKNDYQET"
     protocluster    1..13686
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2097:3686]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2098..3686
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13686
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13686
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             119..1624
                     /locus_tag="ctg193_2"
                     /transl_table=11
                     /translation="MSNNIRIRKKKLKGTGIFAAAALTAALIAGNNIPGVTRQVSAAES
                     QENTVSSLIPDNITLDKPVELADVELPATEYGTFEWADGSFVPAQRVQSCEVLLIPAEG
                     QDLSHVDGWDPESGAVVGYINVIVNSITDGDNVDKTEGSGKTDPTENADPTETPETSSE
                     KPAADENADTDNKEDKESKSDQDNKTDTDNEESKIEEDKTDNKNNKDNNSNADKTDKDT
                     ETTGKLEPADDMTQDKEDTKKDDEDGADDNIFDNPVLPDDKDDRPTDAEDSLSDEEKEE
                     RAALNHTCDGITVSGVNLPWYVQFRVSSGDSYQFTNESDAMIFQSYEFELWDLKNNTEY
                     EIPNGDYISVTVPVKSGYQYTIEHLLDNGATETIIPSVENGIMVFSTHSFSPFGIAGSR
                     QLVGPDAGNDTDDTDAVTPAPASSDSQSSDSGKNNTVSMNDSSDSNNGSSSDQNDNSTE
                     NKAVKNNNTVNTGDTTSIMPFVILFVAAAVIAGVVVFIKKRKK"
     CDS             1674..2024
                     /locus_tag="ctg193_3"
                     /transl_table=11
                     /translation="MKVRAILKSLLFAYALTGVALLLLALVLFAFDLGETAVDAGIIII
                     YVLACFMGGFMAGKIVRKDKYLWGVITGLAYYVLLLTVSIMAKGGWDMSAAHAVTTFFM
                     CTGGGTLGGMLS"
     CDS             2098..2238
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg193_4"
                     /sec_met_domain="TIGR03973 (E-value: 6.6e-28, bitscore:
                     87.3, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 8.4e-28, bitscore: 87.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQ
                     K"
     CDS             2319..3686
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg193_5"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.2e-29,
                     bitscore: 92.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.2e-16, bitscore: 51.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.9e-14, bitscore: 45.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.9e-20, bitscore:
                     62.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEA
                     IAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIA
                     HDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNW
                     QVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHD
                     YMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQI
                     SVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCV
                     YKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYT
                     KKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD"
     CDS             3798..6206
                     /locus_tag="ctg193_6"
                     /transl_table=11
                     /translation="MKKSKGIVVLLLTLILTVFFCFTAAVGIGPTGTGAAKHINTGLDL
                     AGGVSITYQAKESNPTSEEMSDTIYKLQKRVEQYSTEAQVYQEGSDRITVEIPGVTDAD
                     TILNDLGKPGSLYFITKEDADGNQNFTTGQDGYVLSRTMDEIKESGSVVLEGSDVADAQ
                     GGAIQNQNTSAKEYVVSLTLTSDGENSGKTKFAEATKNNVGKQIAIVYDNNIISAPNVN
                     EEISGGKAQISGMSDLEEAQNLASYIRIGSLGLELEELRSSVVAAQLGEEAISTSVLAG
                     AIGLIIVIIFMIIAYRVPGVVAGIALILYTSLMLITLNAFDITLTLPGIAGIILGIGMA
                     VDANVIIYARIREEIGAGVSVRNSIKSGFSKAFSAIFDGNITTLIAAFVLMWLGSGTVK
                     GFAYTLALGIVISMFTALVVSRLIVNALYAVGVRDPKFYGSAKERKAVDFLGKKKVFFA
                     ISIILILCGPAAMFANSHAGNKALNYSLEFSGGTSTTVTFNEDMDIKTIDSEVTPVVEE
                     VTGDKNVQPTKVVGTNQVVIKTRSLNQSEREALQSALVEKFGVDDSTISTESISSTVSS
                     EMRRDAIVAVIVATICMLLYIWFRFKDIRFASSAVLALLHDVLVVLAFYAIARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLHSGSREKLAEIVNTSITQTLTRSIYTSFTTFV
                     MVAVLYIMGVSSIREFAAPLMVGVLVGAYSSVCITGALWYVMKKKFAGKGQPAIAAASA
                     SAKSSSKPKKARDVSQKDPTQPKKKNRKRVAERLAAEEAAKKQQNDDAE"
     CDS             6288..8000
                     /locus_tag="ctg193_7"
                     /transl_table=11
                     /translation="MEKWVIAAKRADFNQIGQQFHIDPVIARLIRNRDVIGEDKIREYL
                     SGTVQELPSPWLMKDMEKAVDILEKKISQKAKVRIIGDYDIDGVTSTYILMKGLARIGA
                     DVDTYIPDRVADGYGIHAHLIERAETDRIDTIVTCDNGIAAAAEIQMAKDKGMTVIITD
                     HHEVPYREEKGERQMVLPPADAILNPKQYDCPYPNKNLCGAVVAFKYIAALYERFGVPA
                     EELEDYYELAAIATVGDVMDLQGENRILVKEGLCRLKNTKNQGLQELIRANSLEDAKIT
                     AYHIGFVLGPCINASGRLDTAARSLALLNAKTKEEAARLAGDLTALNQSRKALTEKGKE
                     EAIRIIETTELKNDRVLVVYLPDCHESLAGIIAGRIREKYHRPAFVLTGGETSAKGSGR
                     SIESYSMYEELVKCADLMIQFGGHPMAAGLSIEEKNIEEFRRRLNVNCTLTDEELRPKI
                     VIDVPMPVSYITKELVEQISLLEPFGKGNTKPVFAQKNLRVLDHSIIGKNKNVVKLKLL
                     DPQGISVEGIYFGEAEDFVNFIREKDSISVTYYPEINRFRGRESLQIIIQNYC"
     CDS             8148..8672
                     /locus_tag="ctg193_8"
                     /transl_table=11
                     /translation="MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCL
                     KDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEM
                     HKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGY
                     DVASVICYDGK"
     CDS             8710..11040
                     /locus_tag="ctg193_9"
                     /transl_table=11
                     /translation="MTEITKSTEAKKDEMQVEKEKLESVKRADAAVKTMHDFTSPEVLY
                     KELINSVLKYHPSTDISMIEKAYKVASEAHEGQKRKSGEPYIIHPLCVAIILADLELDK
                     ETIVAGLLHDAVEDTWMTYEEVEKEFGSEVALLVDGVTKLGQLSYSADKVEVQAENLRK
                     MFLAMAKDIRVILIKLADRLHNMRTLQYMRPEKQQEKARETMDIYAPIAMRLGISKIKV
                     ELDDLSLKYLKPDVYYDLVHKVALRKSEREQFVGAIVKEVKKHMDDANIKAQVDGRVKH
                     FFSIYKKMVNQDKTIDQIYDLFAVRILVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMP
                     KPNMYQSLHTTLIGPNGQPFEIQIRTYEMHRTAEYGIAAHWKYKESSDGKAPVGKSEEE
                     KLNWLRQILEWQRDMSDNKEFMSLLKNDLDLFADSVYCFTPQGDVKTLPSGSTPVDFAY
                     SVHSAVGNKMVGARVNGKLVPIEYEIKNGDRIEIITSQNSQGPSRDWLKLVKSTQAKNK
                     INQWFKKELKEDNILKGKEMLAQYARAKGFKITNYTKTQYLEAVLRKYGFRDWDSVLAA
                     IGHGGLKEGQVFNKLVEAYDKENKKNLTDEQVLEAASETQEKLHIAKSKSGIVVKGIHD
                     VAVRFSKCCNPIPGDEIVGFVTRGRGITIHRTDCVNVLNMSETDRTRLIEAEWQQPDTK
                     EKEKYMAEIQVYANNRTGLLVDLSKIFTERKIDLRSINSRTSKQEKATISMSFEIGSKE
                     ELRSLIEKIRQVESVIDVERTTG"
     CDS             11105..11734
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     163; E-value: 1e-49)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg193_10"
                     /transl_table=11
                     /translation="MKNLELQKCILGPVYTNCYLLKNKETGELIIVDPADCPEKIEMKI
                     SRMNGKPVAILLTHGHFDHILAAQAVKEKYNIPIYACHQEEEMLREPSINMTVHYGQGC
                     SIVPDVFLEDLDVIRLAGFSVQMIHTPGHTKGSCCYYLKDEGVLFSGDTVFYGSVGRTD
                     FPGGSTAEIVRSLHKLVDSLPEETEVFPGHDASTTIGYEKRYNPFV"
     CDS             11727..13241
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg193_11"
                     /sec_met_domain="PF04055 (E-value: 3e-25, bitscore: 80.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCKIGILFENRDFEHDVYELIKAFYPEAEIHTLYENAEAEYDLRF
                     SVERDNDSYIIKYERTENLSKQETEQKGVISADILSKENAGCGIQDAHALRKENKDNIK
                     YALYQLLVKLTGRNLPWGNLTGIRPAKLAMGMIESGMKNTEAAREMRERYLVSPQKTAL
                     AITIANREREILKDIDYENGYSLYIGIPFCPSICLYCSFSSYPLKVWEKRTDEYVEALC
                     REVRETALMMKGRKLDTIYIGGGTPTTLLPHQIRKLLDTVGEAFGYEGLAEFTVEAGRP
                     DSITREKLMTIREYPVTRISVNPQTMNQETLDIIGRRHTVEQTKEAFRLARELGYDNIN
                     MDLIVGLPGEDIHMVERTLEQIRELAPDSITVHSLAVKRAARLNIFKEKYQEMSFENNQ
                     EIMDLTMKTAYEMGMGPYYLYRQKNMKGNFENVGYAKVDKAGIYNILIMEEKQPIIALG
                     AGGSSKLVFDHGQRIERVENVKDVSNYISRIDEMIERKRTAIATWL"
ORIGIN
        1 gataatatac agatatgtaa tattattgta ttacgtaaaa agagaactga tatttggctg
       61 aaagtaaaaa atgattatca ggaaacataa gaatcgaata taaatataga ggtgcgatat
      121 gtccaataat ataagaataa gaaaaaagaa attaaaagga acgggtattt ttgcggcagc
      181 ggctttaaca gcggctttga ttgcaggaaa taatataccg ggtgtaacaa gacaggtcag
      241 tgcggctgag tcacaggaga atactgtgtc ttctctgatt ccggacaaca tcacgcttga
      301 taagccagta gaacttgcgg atgtagaact tccggcaacg gaatatggaa cttttgaatg
      361 ggcagatgga agtttcgttc ctgcacagcg tgtacagagc tgtgaggtac ttcttatacc
      421 ggcagaaggg caggatttaa gccatgtgga tggatgggat ccggagagcg gcgcggttgt
      481 cggttacatc aatgtaatag tgaacagtat tacggatggt gataatgttg ataagacaga
      541 aggctcaggt aaaacagatc caacagaaaa tgcagatcca acagaaacgc ctgaaacttc
      601 gtcagaaaaa cctgccgcag atgaaaacgc tgatacagac aataaagaag ataaggaaag
      661 taaatcagat caggataata aaactgatac agacaatgaa gagagtaaga ttgaagaaga
      721 taaaacagat aataaaaaca acaaagataa taacagcaat gcagataaga cggataaaga
      781 tacagaaact accggtaagc tggaacctgc agatgatatg acacaggata aagaagatac
      841 gaagaaagat gatgaagatg gcgcagatga taatatcttt gataatcctg ttctgccgga
      901 cgataaggat gaccgtccta cagatgcaga ggattctctt tctgatgaag aaaaagaaga
      961 gagggccgca cttaatcata cctgcgacgg tattacagta agcggagtta atcttccatg
     1021 gtatgtacag ttcagagttt caagcggtga cagctatcag tttaccaatg aatcagatgc
     1081 aatgattttc cagtcttatg aatttgaact ctgggatctt aagaataata cagaatatga
     1141 gatccctaat ggagattata tcagtgtcac tgtgccggta aaatccggat atcagtatac
     1201 tatcgaacat ctcctggaca acggggcaac tgagacgatt attccgagtg tagagaatgg
     1261 tattatggta ttcagcacac attctttcag tccatttgga attgcaggaa gcagacaatt
     1321 agtaggacct gatgcgggga atgatacgga cgacacagat gcggtaactc ctgcaccggc
     1381 ttcctccgac agtcagagct ctgattccgg aaagaacaat acagtatcta tgaatgacag
     1441 ttctgacagc aataatggtt cttcttctga tcagaatgat aattcaacgg aaaataaagc
     1501 tgtgaaaaat aacaatacag taaataccgg agatacaaca tcaattatgc cgtttgtgat
     1561 actgtttgtg gcagctgcag tgatcgccgg tgtggttgta tttataaaaa agagaaagaa
     1621 ataaaagaat aacactgatt cctcccccat atagtttaac aggaggggaa gcaatgaaag
     1681 tcagagcaat tttgaaatca ctattatttg catatgcatt aacaggagtg gcattactgc
     1741 ttttggccct ggtactgttt gcttttgatc tgggagaaac agctgtagat gcgggtatta
     1801 ttataattta tgtacttgca tgtttcatgg gaggctttat ggccggcaaa attgtgcgta
     1861 aagacaaata tctgtggggt gttatcacag gtctggctta ctatgtatta ctgttgactg
     1921 tctctattat ggcaaaaggc ggctgggata tgagtgcagc gcatgcagtt acaacatttt
     1981 ttatgtgcac aggcggtgga acactgggtg gaatgctgtc gtaaaaaaaa gcttttaaaa
     2041 tgaaaagata tatgatatac tatgccaaga atataattac ataaggagga tagagttatg
     2101 gaacatatca aaaccctgaa tacaaagaat ttacagaaca ctgtaaaaaa aggtggatgt
     2161 ggcgagtgcc agacttcctg ccagtccgca tgtaaaactt cctgtacagt aggaaaccag
     2221 agctgcgagc agaaataaga tcagctatgg agaaatgaga taagcagcgg aacttttatt
     2281 ccgctgctta tcttacgctt agaaaggatt ttagtaaaat gagtctgatt caccgttata
     2341 aaagcaatgg ctttaatatt gtactggata tcaacagtgg atgcatccat ctggtagatg
     2401 aggttacata tgaggttctt ccatatctgg aagagggcct tggcacagaa gctattgcag
     2461 agaaactgga aaacaaatat aacagagaag atattgagac atctgtaaga gaatgtaata
     2521 agctgaaaga agatggaatg ctttttacaa aagatgttta tgagaatgta attgaagaat
     2581 tttcaaataa ccggcagacc gttgtaaaag cattgtgcct gcacattgct catgactgca
     2641 atctggcctg ccgttattgt tttgccgaag aaggcgaata tcatggcaga agagctctta
     2701 tgtcctatga agtcggcaaa aaagctcttg atttcctgat cgcgaactcc ggttccagaa
     2761 aaaacctgga agtagatttc tttggcggcg agccgctgat gaactggcag gttgtaaaag
     2821 atctggtaaa atatggcaga gagcaggaaa agcttcacaa taagaaattc cgtttcactt
     2881 taacaacaaa cggagttctt ctgaatgatg aagtaatgga attctgcaat aaagagatgg
     2941 gcaacgttgt actcagtgtg gacggacgta aggaagtaca tgactacatg cgtccattca
     3001 gaaaaggtgc aggaagctat gacctgatca tgccgaagtt ccagaagttt gcagaatcca
     3061 gaaatcagga caagtattat gtaagaggta cttttactca ccataatctt gatttctcca
     3121 aggatgtgct tcatctggca gatcttggat tcaaacagat ttctgtagag cctgtagttg
     3181 cggctgatac ggaggaatat gcgatccgcg aggaggatat cccccagatc atggaagagt
     3241 atgatactct tgcaaaagaa atgattaaaa gagagaaaga gggaaaagga tttaacttct
     3301 tccattttat gatcgacctt acaggtggcc cttgcgtata caagagactg tcaggctgcg
     3361 gttcaggaac agagtacctg gctgtaacac cctggggtga tttttaccca tgtcaccagt
     3421 ttgttggtga agaacagtat ctcatgggaa atgtagacga aggcatcaca aagccggaaa
     3481 tccagaagga attcggcgga tgcaacgttt acacaaagaa agactgcaaa gactgcttcg
     3541 cacgtttcta ctgtagtggc ggatgtgcgg caaatgcatt ccatttccag ggagatatca
     3601 aaggcaatta tgaaatcgga tgcgaactcc agagaaaacg tgtggagtgc gccatcatga
     3661 taaaagccgc actggcatgt gattagtggg cagtaatctg tctgactgat accgccgtcg
     3721 gctgttatca taacagaaaa tggctggcag gcggatgaac atgaccgcgg acaaaaaatc
     3781 aagaagggaa aagaactatg aagaaaagta aaggaatcgt agtgctgctt ttgacactga
     3841 tcctgactgt gttcttttgc tttactgcag ccgtaggtat cggtcctacc ggaaccggtg
     3901 cagcaaaaca tatcaacacg ggtcttgatc ttgccggtgg tgtcagcatt acctaccagg
     3961 ctaaggagag caatccgaca agcgaagaga tgtcagatac gatctacaag cttcagaagc
     4021 gtgtagagca gtacagtact gaggctcagg tataccagga aggatcagac cgtattacag
     4081 ttgaaattcc tggtgttaca gatgcagata ctattttgaa tgatctgggt aaaccaggtt
     4141 ccctgtattt catcacaaaa gaagatgctg acggaaacca gaactttact acaggacagg
     4201 atggatatgt tctctccaga actatggatg agatcaagga atccggaagt gttgttctgg
     4261 aaggttctga tgtagcagat gcccagggtg gtgcgatcca gaatcagaac acaagtgcaa
     4321 aggaatatgt ggtaagtctt actcttactt ctgatggaga aaacagtggt aaaacaaaat
     4381 ttgcagaagc tacaaagaat aatgtaggca agcagatcgc tatcgtctat gacaataaca
     4441 ttatcagtgc tccgaatgta aatgaagaga tttccggcgg aaaagcacag atcagcggaa
     4501 tgtctgacct ggaagaagca cagaaccttg cttcttatat ccgtatcggt tctctgggac
     4561 tggaactgga agaacttcgt tccagtgttg tagctgcaca gcttggtgaa gaagcaatct
     4621 ctacaagtgt tcttgcaggt gcgatcggtc tgatcatcgt tattatcttt atgatcattg
     4681 cataccgcgt acctggtgta gttgcaggta ttgcactgat tctttataca tcattaatgc
     4741 tgatcacgct gaatgccttt gatattactc ttactcttcc gggtattgcg ggtattatcc
     4801 ttggtatcgg tatggcggtg gatgccaatg ttattattta tgcccgaatc agagaggaaa
     4861 ttggtgcagg agtttcagta aggaattcta ttaagtccgg tttcagcaaa gctttctctg
     4921 caatctttga tggaaatatt acaacgctga tcgcagcctt tgtgctgatg tggcttggtt
     4981 caggtactgt taagggattt gcttatacac ttgcccttgg tatcgtgatc tccatgttta
     5041 cagcactggt tgtatccaga ctgattgtaa atgcacttta tgcagttggt gtacgtgatc
     5101 cgaaattcta cggatctgca aaagaacgta aggcagttga tttccttgga aagaagaaag
     5161 tattttttgc tatttccatt atcctgatcc tctgcggtcc ggcagcgatg tttgctaatt
     5221 cgcatgcagg aaacaaagcg ttaaattaca gccttgagtt ctcaggcggt acttctacaa
     5281 ctgttacatt taatgaagat atggatatta agaccattga ttctgaagta actcctgttg
     5341 tagaagaggt gacaggagat aaaaatgttc agcctacaaa ggtagtcgga acaaatcagg
     5401 ttgtgatcaa gacacgttct ctgaatcaga gcgaacgtga agctctgcaa agtgcactgg
     5461 ttgagaaatt tggtgtagat gacagcacga tttccacaga aagtatttct tctacagtaa
     5521 gtagtgaaat gcgtcgtgat gcgatcgtag ccgttatagt agctacaatc tgtatgcttc
     5581 tttatatctg gttcagattt aaagacatcc gttttgcaag cagtgcggta ttggcgcttc
     5641 tgcatgatgt tctggttgta cttgcattct atgctattgc cagagtatct gtcggtaata
     5701 catttattgc ctgcatgctt acgatcgtag gttattctat caatgctaca atcgttattt
     5761 ttgaccgtat acgtgagaac cttcacagtg gttccagaga aaaactggca gaaattgtaa
     5821 acacaagtat cactcagact cttacaagaa gtatttatac ctcttttaca acttttgtta
     5881 tggtagctgt tctttatatc atgggtgttt cttctatccg tgaatttgca gcacctctga
     5941 tggttggtgt tcttgtcggt gcatattctt ctgtatgtat tacaggtgcg ttgtggtatg
     6001 tgatgaaaaa gaaatttgca ggaaaaggac agccggcaat tgctgcagcc tccgcatctg
     6061 caaagtcctc ttcaaagccg aagaaagcac gtgatgtatc acagaaagat ccgactcagc
     6121 caaagaagaa aaacagaaaa agagtagctg aacgtctggc tgccgaagaa gcagctaaaa
     6181 aacagcagaa tgatgatgct gaataaaaca ataattgtct gaaaaacagg cagacagaaa
     6241 tatcccgggg taaaactccg ggatattttt atgaggagag aaaatatatg gagaaatggg
     6301 taatagcagc aaaaagagca gattttaacc agatcggtca acagtttcat attgatccgg
     6361 tgattgcgag actgatcagg aacagagatg tgatcggaga agataagata agagagtatc
     6421 tgtcaggaac agtacaagag cttccttctc cctggctgat gaaggatatg gaaaaagctg
     6481 tagatatcct ggagaaaaaa atatcgcaga aagcaaaagt ccgtattatt ggtgattatg
     6541 atattgatgg tgtgacctct acatacattt taatgaaagg tcttgcgagg atcggagcag
     6601 atgtggatac ttatattccg gacagagttg cagacggata tgggattcat gcacatctta
     6661 tagaaagagc ggaaacggac cggatcgata cgatcgtgac ctgtgataat ggaattgctg
     6721 cggctgctga aatccagatg gcaaaggata agggaatgac agtgattatt acagatcatc
     6781 atgaggttcc ttacagggag gaaaagggag aacgccagat ggtgcttccg ccggcagatg
     6841 cgattttgaa tccgaaacaa tatgattgtc catacccgaa taaaaacctg tgtggggcag
     6901 tggtggcctt taaatatatt gcagcacttt acgagagatt tggtgttccg gcagaggagc
     6961 tggaagatta ttatgaactg gcggctattg caacagtagg agatgttatg gatcttcagg
     7021 gagagaacag gattctggta aaagaagggc tgtgccgtct gaaaaatacc aaaaatcaag
     7081 gattgcagga actgatccga gcaaattctc tggaagatgc taaaatcaca gcttatcata
     7141 tcggatttgt gctgggacca tgtatcaatg ccagtggcag actggataca gctgcccgtt
     7201 ctcttgcact tctcaatgca aaaacaaagg aagaagcagc aaggcttgcc ggagatctta
     7261 cagctcttaa tcagagccga aaagctctca ctgagaaagg aaaagaagag gcaatccgga
     7321 ttatagagac tacagagctg aaaaatgaca gagtactggt agtttatctt ccggattgtc
     7381 atgaaagtct tgccggtatt atagcaggca ggatcaggga aaaatatcac aggccggcct
     7441 ttgtattgac gggcggtgag acaagtgcaa aaggaagcgg aagatcaata gaaagttact
     7501 ctatgtatga agaactggta aaatgtgcag acctgatgat acagtttgga ggtcatccga
     7561 tggcagcagg tctgtctata gaagaaaaaa atatagaaga attccggaga cgcctcaatg
     7621 tcaactgtac gttgacggac gaagaattgc gtcctaagat cgtgattgat gtgccgatgc
     7681 ctgtgtctta tattacaaaa gaactggtag aacagatttc gcttctggaa ccctttggaa
     7741 aagggaatac aaaaccggtc tttgcgcaga aaaatctcag agtgcttgat cacagtatta
     7801 tcgggaaaaa taaaaatgta gtaaaactaa aacttctcga tccgcagggg atttcagtgg
     7861 aaggcattta tttcggagaa gcagaggatt ttgtgaactt tatcagggaa aaagacagta
     7921 tttctgttac ttattatccg gagatcaaca gattcagggg acgagagagt cttcagatta
     7981 ttattcagaa ttactgttaa tattaccgct tggtttgtaa ccgccggtaa gcctggaaat
     8041 acaaatgtca gggcttaaca gtaacttgat tctgaaataa aaaggtgata tactataaaa
     8101 tatttatgag cgaacagcaa tataacacac actggaggag aaataaaatg aagaaaattg
     8161 aagattatgt attaagtata ccggattttc ctgaaccggg gattattttc agagatatta
     8221 caagtgttct gcaggacgcg gatggcctgc agttggcaat cgactccatg caggactgtc
     8281 ttaaggatat agatgtggac gtgattgcag gaacagagtc cagaggcttt atctttggtg
     8341 taccgatcgc atataatctt cataaaccat ttgtaccgat tcgtaaaaaa ggtaaacttc
     8401 cccgcgaaac agtatctgta agctatgatc tggaatatgg cagtgcagag attgaaatgc
     8461 ataaagattc cataaaacca ggtcagaaag tggttatcgt tgatgatctg atcgcaacag
     8521 gcggtacgat cgaagcagcg atcaagctgg tggaacagct tggcggtgag gttgtcaagg
     8581 ttgtatttct catggaactt gcaggtttaa agggacgcga aagactgaat gggtatgatg
     8641 tagcgtctgt aatttgttat gatggtaaat aagcacagct gattgtgcag gacaggcagg
     8701 tgggagcata tgacagagat aacaaaaagt acagaagcaa aaaaagatga aatgcaggtt
     8761 gaaaaagaga agctggaatc tgtaaagaga gcagatgcgg cagtaaagac catgcatgat
     8821 tttacaagtc cggaggtgct ttataaagaa ctgataaaca gtgttctgaa gtatcatcca
     8881 tcaacagata tttccatgat agagaaggca tataaggttg caagtgaagc tcatgaagga
     8941 cagaagagaa agtctggaga gccatatatc attcatcctt tgtgtgttgc catcattctg
     9001 gcagatctgg aacttgacaa agaaacgata gttgcaggtc ttcttcatga tgcagttgaa
     9061 gatacctgga tgacctatga ggaagttgag aaggaatttg gttcagaggt tgcacttctt
     9121 gtggatggtg ttaccaagct gggacagtta tcttattctg cggataaagt agaagttcag
     9181 gcagagaacc tcagaaagat gtttcttgcc atggctaagg atatcagagt tattctgatc
     9241 aagcttgcag accgtcttca taatatgcgt accttacagt atatgcgtcc tgaaaagcag
     9301 caggaaaagg ccagagagac catggatatt tatgctccta ttgccatgcg tctgggtatt
     9361 tccaagataa aggtagagct ggatgacctg tcgctgaaat accttaagcc ggatgtatat
     9421 tatgacctgg tgcataaggt ggccctgcgt aaaagtgaga gagaacagtt tgtaggtgcg
     9481 attgtaaaag aagttaagaa acatatggat gatgccaata ttaaggcgca ggtggacgga
     9541 cgtgtaaaac actttttcag tatctacaag aagatggtaa atcaggataa gactattgat
     9601 cagatttatg atttatttgc tgtccgtatt cttgtagata cagtgaagga ttgttatgct
     9661 gctcttggtg tgatccatga gatgtataag ccgattccgg gacggtttaa agattatatt
     9721 gccatgccga aacccaatat gtatcagtca ttgcatacca cattgattgg acctaacgga
     9781 cagccctttg aaatccagat ccgtacttat gaaatgcaca gaactgcaga atatggtatt
     9841 gctgcacact ggaaatataa agagtcgtct gacggaaagg ctcctgtagg taagagtgag
     9901 gaagagaaac tgaactggct gcgtcagatt ctggaatggc agagagacat gtctgataac
     9961 aaagaattca tgagtcttct gaagaatgac ctggatcttt ttgcggacag tgtttactgt
    10021 ttcactccac agggagatgt taaaacactt ccaagcggtt ctacaccggt ggattttgcg
    10081 tacagtgttc acagtgcagt cggaaataag atggtaggtg ccagagttaa cggtaagctg
    10141 gttccgattg aatatgagat caaaaacggt gaccgtattg agatcattac ttcccagaac
    10201 tctcagggac caagccgcga ctggctgaaa ctggttaaga gtacgcaggc aaagaacaag
    10261 attaaccagt ggttcaagaa ggaattaaaa gaagataata tccttaaggg caaggagatg
    10321 cttgcgcagt atgcgcgtgc aaaggggttt aagatcacaa attatacaaa aacccagtat
    10381 ctggaggccg ttttgcgtaa atatggtttc agggactggg attcagtact tgctgcaatt
    10441 ggtcatggcg gattgaaaga aggtcaggtt ttcaataagc tggtagaggc atatgataag
    10501 gaaaataaga agaatctgac agatgagcag gttcttgaag ctgcttctga gacacaggag
    10561 aagcttcaca ttgccaagag caagagtgga attgtggtaa aaggaatcca tgatgtggca
    10621 gtccgttttt ccaagtgctg taatccgatc ccgggtgatg agattgtagg ctttgttaca
    10681 agaggacgtg gaatcacaat tcatcgtaca gattgtgtca atgtgctgaa tatgtctgag
    10741 acagacagga cacgactgat tgaggcagag tggcagcagc ctgataccaa ggaaaaagag
    10801 aagtatatgg ctgagattca ggtttatgca aataaccgta cagggcttct tgtggatctt
    10861 tctaaaatat ttacagaacg taagatcgac ctgcgaagta ttaacagccg tacaagcaag
    10921 caggagaagg caactatttc catgagtttt gagattggaa gcaaagagga actgcgttcc
    10981 ctgatcgaga agatccgtca ggtagagagt gtcattgacg tagagagaac tacaggctga
    11041 tcatggaaaa atctgctgga acattatttt atggaactgc tgcagattga cagaaaggaa
    11101 taacatgaag aatttagaat tacagaaatg tatattagga cctgtatata caaattgcta
    11161 tctccttaag aataaagaaa ccggagaact gatcattgtt gatcccgcag attgtccgga
    11221 gaagattgaa atgaagattt cccgaatgaa tggaaaaccg gtggcgattc ttcttaccca
    11281 tggacatttt gaccacattc tggctgcaca ggcagtaaag gagaaatata atattccgat
    11341 ttatgcctgt catcaggaag aggagatgct ccgcgaacct tcgatcaata tgactgtaca
    11401 ttatggacag ggatgttcta ttgtgccgga tgtatttctg gaggatctgg atgttatcag
    11461 actggcggga ttttctgttc agatgatcca tacaccggga cataccaaag gaagctgctg
    11521 ttattatctg aaagatgaag gtgtattgtt cagcggtgat acagttttct atggctctgt
    11581 tggaagaacg gattttccgg gtggaagtac agcagaaatt gtgagaagtc tccataaact
    11641 ggtagattcg cttcctgaag agaccgaggt tttccccgga catgatgcat ctaccactat
    11701 tggttatgaa aagaggtata atccatttgt gtaaaatagg cattctgttt gagaacagag
    11761 attttgaaca tgatgtttat gaactgatca aagcgtttta tcccgaagcg gagatacata
    11821 ctctttatga aaatgctgaa gcagagtatg acctccgctt cagtgtggaa cgggataatg
    11881 acagttatat cataaaatac gaaaggacag agaatctgtc gaaacaggaa acagagcaaa
    11941 aaggggtaat ttccgcagac atactttcta aagagaatgc aggctgtgga atacaggatg
    12001 ctcatgctct gagaaaagag aataaagata atatcaaata tgctctgtat cagttgttgg
    12061 taaaactgac gggcagaaat cttccatggg gaaatctgac aggaatacgt cctgccaaac
    12121 tggcaatggg aatgatcgaa tccggaatga aaaatacgga agcagcccgg gagatgcgtg
    12181 agagatatct ggtaagtccg cagaaaacag cgcttgccat cactattgca aacagggaaa
    12241 gagagattct gaaggatatt gactatgaaa atggatacag cctttatatt ggaatcccgt
    12301 tttgcccaag tatctgtctg tattgttcct tcagctccta tccgctgaaa gtgtgggaga
    12361 agagaacaga tgaatatgtg gaagctctct gccgggaggt aagagagact gctcttatga
    12421 tgaagggaag aaaactggac accatctata ttggcggcgg taccccgact acactgcttc
    12481 cacatcagat ccgtaagctc ctggatacag tgggagaagc ttttggctat gaaggactgg
    12541 cagagtttac tgtggaagcc ggcagaccgg acagtattac acgtgaaaag ctgatgacga
    12601 tcagggagta tccggtaaca agaatttccg taaatccaca gaccatgaat caggaaaccc
    12661 tggatattat cggccgcaga catactgtgg agcagacaaa agaagcgttt cgtctggcaa
    12721 gagagctggg atacgataac attaacatgg atctgatcgt aggccttccg ggtgaggata
    12781 ttcatatggt agaacgtact cttgaacaga ttcgtgaact ggcaccggac agtattaccg
    12841 tacattcact ggcagtgaaa cgtgcagcaa ggctgaatat ttttaaagag aaatatcagg
    12901 aaatgtcttt tgagaataat caggagatta tggatctgac catgaaaaca gcatatgaaa
    12961 tgggaatggg cccttattat ctgtacagac agaagaatat gaagggaaat tttgaaaatg
    13021 ttggctatgc aaaggttgac aaagcgggaa tttacaatat actgattatg gaggaaaaac
    13081 agcctatcat cgcactgggg gcaggcggtt cttccaagct ggtctttgac catggacaga
    13141 gaattgaacg tgtggagaat gtaaaagacg tttctaatta tatttcccgc attgatgaga
    13201 tgatcgagag aaaacggaca gcaatagcta cctggctgta ggatgtggag gtaacatttt
    13261 ggacacagta caaaagacag cagcaggttc acagcagagg atcctggaat ttgaccttgc
    13321 ttctgaactg catcatggaa tgctggtaag taatctggct tatgcggttg cagaggagat
    13381 gggactgccg catgaacagt gttatgagct tgcaatagca ggaatgctcc atgatatagg
    13441 aaagctgaag ctgacaagtt atattaacgg acaggagcag gatcctctgg tgatcgagga
    13501 actgaagtat gtccggatgc attctgcatt gggatatgag gaacttaaag ggcagggata
    13561 ttcggatttt gtattggaga gtatcctgta ccatcatgag aattatgatg gtagtggata
    13621 tccgtccaat aaagcaggtg atgatatacc cataggtgcc cggatactca gagtctgcga
    13681 tgtata
//
