LOCUS       gnlProkkaLPHPPLIL_33   15228 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LPHPPLIL_33.
ACCESSION   gnlProkkaLPHPPLIL_33
VERSION     gnlProkkaLPHPPLIL_33
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 06:43:57
            Original ID  :: gnl|Prokka|LPHPPLIL_33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 58200
            Orig. end    :: 73428
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15228
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15228
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15228
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(711..1523)
                     /locus_tag="ctg33_53"
                     /transl_table=11
                     /translation="MISLTKHNELKGYKSLEAYPEVAHFVTTRHEGISTGAYGSFNCSP
                     YTNDSCMNVNRNQSWLFQCMNHQIKELFIPEQNHGCASLIINESFFKESLEMRRLLLRG
                     MDALITNVPGYCVCVTTADCVPVLLYDKKQHVVAAVHAGWKGTVKHIVSHVMDHLNKMF
                     GTQGEDVIACIGPSISLESFEVGDEVYDAFEESGFDMSLISMKKKETGKYHIDLWEANR
                     IELLNLGVPAEQIEVAGICTYIHHDEFFSARRLGIDSGRTLSGIMIRK"
     CDS             complement(1520..2683)
                     /locus_tag="ctg33_54"
                     /transl_table=11
                     /translation="MAESNFVDYVKIYCRSGKGGRGSTHMRREKYCPNGGPDGGDGGRG
                     GHIILRGNRNYWTLLHLKYDRHAMAGHGESGSKGRSFGKDGADKIIEVPCGTVVYNAET
                     GEYLCDVTEDGQEVVLLKGGRGGQGNWHFKTATRQAPRFAQPGEPMQEMTVIMELKLLA
                     DVGLVGFPNAGKSTLLSSISAAKPKIADYPFTTLEPNLGIVSYHGGKSFVMADIPGIIE
                     GASQGKGLGLRFLRHIERNSLLLFMVPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLA
                     VTKSDMLDQELMDEIEPTLPEGIPHVFISSVSGLGISVLKDILWEELNKESNKIEDIVH
                     RPKDVTRLQQELKDMGEDEDIVYEYEEDVDDDDDIDYEYEEEDWEEK"
     CDS             complement(2773..3342)
                     /locus_tag="ctg33_55"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAVDKL"
     CDS             complement(3402..3938)
                     /locus_tag="ctg33_56"
                     /transl_table=11
                     /translation="MDTIQIKDKLFTVSIKEQEIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGITSTGVIKEVIGLNEDIAGRTIVIVEDI
                     VDTGLTMQRLLETLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             complement(3979..5523)
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 46.7; E-value: 2.8e-14)"
                     /gene_kind="transport"
                     /locus_tag="ctg33_57"
                     /transl_table=11
                     /translation="MSALKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASTLDNTN
                     LAHWMMYGGLGFLILGNGCFKPTVSSLVGQLYEPGDRRLDAAYTIFYMGVNVGSFAAPL
                     ICGYLGDTGDPHDFKWGFLAAGIMTLFTVVLFETQKNKYLFSPSGEPIGIIPDAKREKK
                     EDKAGHISHPKMDKRTKVRNTLVITILTIALIAFFNYAFEGDWVSIGIFTACIVFPVLI
                     LLDGSLTKIERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTNRDIFGWEMPASW
                     FQSFNPLFVVVLAYIMPGVWGFLNKRKMEPASPTKQAIGLLLLSLGYLFICFGVKDAVP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEAGKVKSIFGYQIATMYDFFMVFVVMSGVASLILFLLSKKLQKMMHGVE"
     CDS             complement(5717..5941)
                     /locus_tag="ctg33_58"
                     /transl_table=11
                     /translation="MMEKTKIGLNAGKVWRILNEKGELSMFDLCRELSLTFEDVALAIG
                     WLAREDKIFLRKREGMLFASIENVEFTFG"
     CDS             6612..6728
                     /locus_tag="ctg33_59"
                     /transl_table=11
                     /translation="MRNTLKYYENKVAFEPKYGRTYEKYRFEKVFLIRYLFD"
     CDS             7008..8519
                     /locus_tag="ctg33_60"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYST
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWQLVSE"
     CDS             8593..9660
                     /locus_tag="ctg33_61"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             9698..9982
                     /locus_tag="ctg33_62"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10001..10351)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_63"
                     /sec_met_domain="PqqD_RRE (E-value: 1.7e-10, bitscore:
                     32.8, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.4e-17, bitscore: 53.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYELRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(10449..11837)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg33_64"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(12087..12482)
                     /locus_tag="ctg33_65"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(12489..13262)
                     /locus_tag="ctg33_66"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(13268..13795)
                     /locus_tag="ctg33_67"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(13782..15023)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390; E-value:
                     2.7e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg33_68"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(15033..15227)
                     /locus_tag="ctg33_69"
                     /transl_table=11
                     /translation="MTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARANPLRKQ
                     YYEKRDDSDKLKLDTVDED"
ORIGIN
        1 gaagaatacg atttcgcctc catccgattc tgtatagttt cttaataagg tctgtatcat
       61 ttcagcagct tctcgcaaac cttcttttcc gttataaccg ttgactatgg ctaggatatg
      121 agtggttccg agatccattt tcgtacgttc atgatcgctt gtcggggttc cgattcctcc
      181 gaaagaatcg cgatatacag gtaatccttc gatattcaat accccgcgtc cgataccttc
      241 aaacggttct cctgctttgc cgataccgag ttcaaggtgc gtaccttgta ttttgtccgc
      301 gtcaaaacca ccgatcgaat gtcccgtacg aagagacact aaattaataa ggtctaccaa
      361 cgtatcaatc tgatataaag gaattccacg catcaggcgg cggcgtagag cttcggctga
      421 tggacgataa cgtccggggt ctttgccaca acgcttataa gcctcacggg tagcaaagat
      481 aacgggttga tgtttgatgt cttccatctg tgttgtggaa gtcagttgcc cggtaaaagc
      541 gttaatttcc tgccaaagcc cttcgctgta agctgtattt ttcactgcag catacacggc
      601 ggctccggca aaaaccgggc atgcgtcttt tatttcttta gatactttta tttcaaacat
      661 aacttatcat aaaccaatca tcagcgtcct gcaataacgg acaccaatta ttactttcta
      721 atcattattc ccgacaatgt acgaccggaa tctattccca gtctacgtgc agagaagaat
      781 tcatcatgat gaatataggt acagattccg gccacttcta tctgttctgc aggcactccg
      841 agattcagta attcaatccg gttggcttcc cacaaatcaa tatgatattt gcctgtttct
      901 ttcttcttca tagaaataag agacatatcg aagccgcttt cttcaaaagc atcatacacc
      961 tcatcaccta cttcaaatga ttcgagcgaa atgctcggcc cgatgcaagc tatcacatct
     1021 tcgccttgcg tcccgaacat cttattcaag tggtccatca catgactgac aatatgcttc
     1081 accgttccct tccatccggc atgaacggca gccacaacgt gttgtttttt gtcgtacagc
     1141 aatacaggaa cacaatccgc tgtcgtgaca caaacgcaat atcccggcac attagttatc
     1201 aaggcatcca ttcctcgcag aagtagccgt ctcatttcca atgattcttt aaaaaatgat
     1261 tcattgataa tcagactggc acagccatga ttctgttcag gaataaataa ttcctttatc
     1321 tgatgattca tgcactgaaa caaccagctc tgattgcgat tgacattcat acatgagtcg
     1381 ttggtataag gcgaacagtt gaaagagccg taagctccgg tgcttatacc ttcgtgacgc
     1441 gtagttacaa aatgagctac ttcgggatat gcctccagtg acttatatcc cttcaactcg
     1501 ttatgttttg taagtgaaat catttttctt cccaatcttc ttcttcgtat tcataatcga
     1561 tatcatcgtc atcgtcgaca tcttcctcat attcataaac gatgtcttca tcttcgccca
     1621 tgtctttgag ttcctgttgc agacgggtca cgtctttcgg acggtgaacg atgtcctcta
     1681 tcttattgct ttccttgttc agttcttccc aaaggatgtc tttcaacacc gagatgccca
     1741 aaccggaaac agaagatatg aatacatgtg gaatgccttc cggcaatgta ggttcaatct
     1801 cgtccatcaa ctcctgatcg agcatatcac ttttggtgac agccaacaca cgttgcttgt
     1861 ccaacatttc aggattgaag gtacgcagtt cgttcagcaa aacttcgtat tctttacgaa
     1921 tgtcgtcgct gtctgccgga accataaaca gcagtaatga attacgctcg atatgacgca
     1981 agaaacgcag tcccaaacct tttccctgac tggcaccttc gataatacct ggtatgtccg
     2041 ccatcacaaa ggattttcca ccgtgatagg aaacgatgcc caagttgggt tcgagcgtag
     2101 taaacgggta atcggcaatt ttcggtttgg cagccgaaat ggaagaaagc aaagttgact
     2161 ttcccgcatt cgggaaacct accagaccga catcggcaag cagtttcagc tccatgataa
     2221 cggtcatttc ctgcatcggc tctcccggct gcgcaaaacg cggagcctga cgggtggccg
     2281 tcttgaaatg ccagttaccc tgaccgccgc ggccgccttt gagcaagacc acttcctgtc
     2341 cgtcttctgt tacgtcacaa agatactccc ctgtctcggc attataaact accgttccgc
     2401 agggtacttc tattatttta tccgcaccgt cttttccgaa gctacgtcct ttgctccccg
     2461 attcaccatg cccggccatt gcgtgacggt catacttcaa gtgcagcaat gtccagtaat
     2521 tacggttacc gcgcaagatg atatgacctc ctcttccacc atcgccccca tcaggacctc
     2581 cgttaggaca atatttctcg cgcctcatgt gcgtagagcc tcttccgccc ttgcccgagc
     2641 gacagtatat ctttacgtaa tcaacaaaat tcgattcagc catatttttt taaagagtta
     2701 aagtagtcag tagttagagc agttaattag aacactccgg ctactgactt atttatttat
     2761 aatattgtat tattacaatt tatctactgc ttcgcagatt tcagcgaaga taccttccat
     2821 agtacccaag ccgttgatgt gttggtattt cttttcgttc ttgtaccagt cgatcagtgg
     2881 agcagtctgt gaatgatata catgcagacg tttcttgatt gtttcttcgt tatcatcagc
     2941 acgaccggaa tccttgccac gtttaatgag acgtaccatc agttcttctt ccggaacatc
     3001 cagatcaacc attacagaaa cgtcctgtcc tctttctgcc aacattttct ttaatgcttc
     3061 tgcctgtgca attgttcttg ggaaaccgtc gaaaattacc cctttgctat ctttgaagct
     3121 gtcgaatacg cttgccagaa tatcaatcat taattcatca ggaatcaatt gaccttggtc
     3181 gatgtaacct ttagctgttt tacccagttc tgtgccattc ttgatttcag cacgcaatac
     3241 atctcctgtc gagatgtgat tgattccata cttttctacg atacgttcgc tctgtgttcc
     3301 ttttcctgaa cccggagcac cgaaaattac gatgttcaac attttgttat ttacaattta
     3361 acgatttact atttaccatt taaactggta cctatttaat attaatctac tactgtataa
     3421 atatcgggat aattacgtcc gaaaccatca taatccagtc cgtaacctac gataaagtcg
     3481 ttcgggattt ccatcgctac atattcaatg ttgaggttta ccttgagctt ttcaggtttc
     3541 accaacagag aagcgatatg aatagcttcg ggattgcgtg tacctaatgt ttcgagcagt
     3601 cgctgcatcg tcagtcctgt gtctacgata tcttccacga tcacaatggt acgtccggca
     3661 atgtcttcat tcaggccgat tacctcttta atcactccgg tggaagtgat gccctgataa
     3721 gacgccaact tcacaaatga gatttcacaa gggatggtga tgtgcttcag taaatcagcg
     3781 gtaaacataa acgaaccgtt caacacacta aggaaaagcg gattcttacc tgctaaatcg
     3841 cggttaattt cgttcgctac gcgaatcact tctttctgaa tttcttgttc cttaatagaa
     3901 acggtaaaca atttgtcttt tatctgaatg gtatccataa ccggtaattt aaaaataacc
     3961 ttgcaaaaat acgatttttt attctacccc gtgcatcatc ttctgtaatt tcttcgagag
     4021 aaggaacaga atcaacgaag caacaccgga catcacgacg aataccataa agaaatcata
     4081 catggtagca atctgataac caaagattga cttcactttt ccggcttccg gatagagccc
     4141 gctcaacatt cccgcaaatt tattggctgt ggcagtagac agataccaga ttcccatcat
     4201 cagggaggcg aaacgcagcg gactcaattt atttaccatt gaaagtccga taggcgacaa
     4261 agctatttca cccatggtat gaataaagta aagtcctgtc agccaaatca tgctcacttt
     4321 cactccggga acagcatctt tcactccgaa acagatgaaa agataaccta aagaaaggag
     4381 taacaaacca atcgcttgtt tggtaggaga agcgggttcc atctttcgtt tgtttaggaa
     4441 accccataca cccggcatga tatatgccag gacaactaca aacagtggat tgaaggattg
     4501 aaaccatgaa gccggcattt cccaaccgaa aatgtcacga ttcgtctgtt cggacgcaaa
     4561 aagagttaaa gaagctcccg cctgttcgta ggctgcccag aagaagatga caaagaaggc
     4621 tactatatag ataacgaaaa tacggctgcg ttctattttg gtcaatgaac cgtctaacaa
     4681 aatcagaaca gggaaaacaa tgcaggcggt aaaaatgccg atactcaccc aatcgccttc
     4741 aaatgcatag ttaaagaagg ctattaaagc aatggtaaga attgtgatta caagggtatt
     4801 acgtactttg gtacgtttgt ccatcttcgg gtgtgagata tggccggcct tgtcttcttt
     4861 cttttcacgt ttagcatcgg ggataatacc aatcggttct ccggaaggag aaaaaagata
     4921 tttattcttt tgagtctcga aaaggacaac ggtgaacagt gtcatgattc cggctgcaag
     4981 aaatccccat ttaaagtcat gcggatcacc ggtatcaccc agataaccac aaatcaaagg
     5041 agcagcaaaa gagcctacat tcactcccat ataaaaaatg gtgtatgcag catccagccg
     5101 cctgtctccg ggttcgtaga gctgacctac cagagaagag acagtgggtt tgaagcaacc
     5161 attgcccaag atcaggaagc ctagtccgcc atacatcatc cagtgggcaa ggtttgtatt
     5221 atctaaagtg gaggcactca taaacatcag gaattgtccg actgccatca tcaccgctcc
     5281 ccaaaacaca gaacgacgga ttccccaata tttatcggca atgtatccgc caatcaacgg
     5341 ggttaaataa actagtccgg tatagctgcc gtagatggat gctgccgctt ctttgtcaaa
     5401 caataatgcc tgcgtcagga aaagaataaa gatcgcacgc ataccgtagt aactgaaacg
     5461 ttctgccgtg cttgtcgcga aaatcagata aaggcctttc ggatgccctt tcaatgcact
     5521 catgaattta tgtgtttagt agtttatggg gtgcaaaggt acagaaaaag tagattagat
     5581 gcttctctta tcaaacagaa taataggggg aatagtaaaa acgagcataa aaaatcctac
     5641 tgatccactt cattactttt ttagcagtgt aaataataaa gtggagatcc atcttaaatg
     5701 taggttagct accaccttag ccaaaagtaa attcgacatt ttcgatactg gcaaaaagca
     5761 ttccttctct tttcctcaaa aagatcttgt cttctcgggc cagccaacca atagcaagag
     5821 ctacgtcttc aaacgtcaaa cttaattcac ggcacaaatc gaacattgaa agttcacctt
     5881 tttcatttaa gatgcgccat actttcccgg cattcaagcc aatttttgtc ttttccatca
     5941 tgcaaacttt agaagattaa acaatccgtt atttagattt taattcattt tcattgtgag
     6001 cactggaaaa tgatgtgatg cacattatct atctccaaag ataacatttt tatcggaaac
     6061 ggcaaataat caaaggctta ataaggggaa ctgcattaaa aatttgttta agaaggtatg
     6121 gcgataaact aaacacaatt tccatccgcg cctctacaga aaaagatttt tcatttctca
     6181 tattctcata aataagaaac aagtggcagt aaactaataa gatagactat gagaaatgat
     6241 ttaaaaacag gcatttctca tagtttcttc gcaaaataac ccggattttg cttcatttct
     6301 catagtgtag tgtgccggaa gctgacattg aataaataaa actatgtatt ccttttgctt
     6361 gcttccatac acagtgtctt agttccacat attgtgggaa aagattccct aaggcttggg
     6421 aaagtattcc cttattttgt gggaaagtat tcccgtatat tgaaggaaaa ctttcccaca
     6481 atatatggga caatcgagac caatgagcat cttcaagcaa aaagccacta ttttatctaa
     6541 atagtagctt catttcctga taaaaataag gcaggctgaa agaaaaaagg aagaacaaat
     6601 ggcttttgac tatgagaaat accctgaaat actatgagaa taaggtggct tttgagccaa
     6661 aatatgggag aacttatgag aaataccgtt tcgaaaaagt gtttctcata agatatctat
     6721 ttgattagct ttcgtttatc gaaaaacaat gagaatatga gaaatgaaat gaagaaatct
     6781 aatctttttc aggagaaata aaagtaagtt cataatggtg ctgcattgaa ttattttttg
     6841 gcggagttat tctaacactt aatagttcaa aagcagatat ttctctgacc caaagataga
     6901 actaatgatg aattaaaagt tgcaattatg gttttcttcc cacaacaaac gggaaaagtc
     6961 agaagaatca tgtacatttg taatccgaaa actaaaagaa catcgcaatg aaaatatttc
     7021 caagcagcag tatcaagaaa ttggacgctt ataccattga gaacgaacct attgcatcaa
     7081 tcgatctgat ggaacgtgca gcaaccgtat taacaaaagc catcacagac agatggaata
     7141 cggaaacgcc ggtcactatc tttgccggac cggggaataa tggcggagac gctctcgccg
     7201 tagcccgcat gatggctgaa aaaggatata aaatcgaggt atttctcttc aacacgaaag
     7261 gagaactttc acccgactgc caaaccaata aagaactggt agaaatgatg gaagaagtaa
     7321 aattccacga gatcagtacc caattcgtac ctcccgtcct gacgcccgac catctggtaa
     7381 tcgacggatt attcggttca ggcctgaaca aaccgttaag cggcggattc gctgccgtag
     7441 tgaaatacat caattcctcc cctgctatgg tagtagccat cgacattcct tccggactga
     7501 tgggagaaga aaacacattc aacgtaaaag ctaatattat ccgtgccgac gtaactttca
     7561 gtctgcaact gccgaagctc gcctttcttt tcgcagagaa cacggaattt gtcggagaat
     7621 gggaagtgct ggacatccaa ttaagcgaag acggtattga agagatggaa acgaactacg
     7681 aaatgttgga aatagagcaa atccgttcac tcatcaagcc acgcaaacag tttgcccaca
     7741 aggggaactt cggccatgca ctattgattg ccggttcaaa aggaatggca ggagcctctg
     7801 ttctcgctgc ccgtgcctgc ctccgttcgg gagtagggtt gctgactgtt catgcgccaa
     7861 tgtgcaacaa cgacatcttg cagacctcca tacccgaagc aatcgtagaa accgacatca
     7921 acgaaacctg ttttgccgta cctaccgaca cggacgacta tcaagcagtc ggcatcggcc
     7981 cagggctggg acgaaacgag gaaacggaag ctgctttatt ggagcaactg gaacattgcc
     8041 agactcctgt tgtggtggat gccgacgcac ttaatatcct cgccaaccac cgtcatgcac
     8101 ttacccacct gccgaagggt tccatcctca ccccgcatcc gaaagaactg gaacgtctga
     8161 ccggcaaatg ccaggactct tacgaacgtc tgatgaaggc ttgcgaattg gctcgtgccg
     8221 cccatgttca cattatttta aaaggagcct actccgccat tatcacccca gaaggtaaat
     8281 gtttcttcaa cccaaccgga aatccgggaa tggcaaccgg aggtagcggt gacgtactga
     8341 ccggagtaat cctggcactg cttgcccaag gttactcaac cgaagaagcc gctaaaatcg
     8401 gcacttacat tcacggattg gcgggcgatg tcgctcaaaa gaagcaagga atgatcggaa
     8461 tgatcgcaag cgatattatc acctgtctgc cgacagcatg gcaacttgta agcgaataaa
     8521 agttaagaac ttaccctttt ttcaataact tcattaactt tgttttcaaa accagttaaa
     8581 aaagaaccga atatgaaaaa gttgattata gcagcaggac tactaatgac aacgtccgcc
     8641 tatgcacaaa ccgaagtact gacaggggtt acccgaggaa aagactatgg agtggtttac
     8701 agtcttccca aaacccaaat agaacttgaa ataaaagcca acaaagtcaa ctatactccg
     8761 ggagaattca gcaaatatgc tgatcgttac ctgcgactga ccaacgtctc cgccgatcct
     8821 gaagagtact gggaactggc tagcgtaaaa gtgaaatccg taggtgtgcc caacagcgaa
     8881 actacgtatt tcgtaaaatt gaaggataag acagtagcac cgcttatgga actgacagag
     8941 gatggcattg tgaaaacgat caatgttcct tacagcaata gcagtgtagg caaaaaagct
     9001 gctcccgccc ccgcagtcct ccaaaagaaa gcgaatcctc gcgaattcct gaccgaagag
     9061 attctgatgg ctagctctac cgccaagatg gccgagctgg tggctaaaga aatctataac
     9121 atccgcgaaa gcaaaaatgc cttattgcgc ggacaggctg acaatatgcc ttcagacgga
     9181 gcacagctta agattatgct cgacaatctg aatgcacagg aagaagccat gacgcaaatg
     9241 ttctccggca cctgtaacaa agaagagaga acattcactg tccgccttac ccctgacaag
     9301 gaattcaaca atgaagttgc tttccgcttc tcgaagaagt taggtgtagt tgccaacaat
     9361 gatttggcag gaactccgtt ttatatcagt ctgaaagacc tgaaatcggt caagatgcca
     9421 caggaagatg gtaagaagaa gaaagatttg gatggaatcg cctacaacgt acccggacaa
     9481 gctatggtta cactgaccga cggtaaaaag aaactttacg aaggtgagct tcctattacc
     9541 caatttggtg tgatagaata tctggctccg gttttgttca acaagaattc taccatcaaa
     9601 gtttattttg atccgaatac gggaggattg ctcaaagtgg acagagaaga agggaaatag
     9661 aaaaacgaag gaagtgaact tctaaaaaac aaagaatatg gttggtgaag gacatgcatt
     9721 cgacatgata cgccgaataa aagagggacg ggaagcttcc cgcctacgtc gtgaacgtgc
     9781 taacgataag ttgaagcatc taaaccgtgc aaacgaacct tatccactac ccaacaccac
     9841 ccccgaagaa atggaacgta tcatccacga ctcggagaaa aagaaagaga aagacagcaa
     9901 ttattttgtt tggggaacgc ttattatcat gggagtcctg atagcaattg ccgtcatact
     9961 ttgggctgta tttatcaaat aaataataat aagttcctat ttatacgact ggtatcacca
    10021 gttttataaa tccatctttc tgcatttgag aaagataagc cgatacacgc aactcgtagc
    10081 cctcttcatt ttgaaagtgg tctgcgagtt tttctataat ctcacgaaca ttgcgttttc
    10141 catctatcag ttcccataca gctgtaccgt gttcttccaa tttcacatga agttctttcg
    10201 acattccttt tggcacaagg aagcgttgca tccacggata tttaaaacgg ggaaaggaga
    10261 gcacaattgt ctccccttcc ctttctgctg taatatgttc actgcgacag ggaatgacct
    10321 ctaacaggtt gattttctct ttggcagcca tacttcttat tttttatttc agagtattca
    10381 tactgatact cttctgttta caccttgata caaaattcct ttgttacttt aggtattgaa
    10441 tttcctagtt acttttggat attcgcctct tccaaaccgt atcccttctt cttgttctct
    10501 gccttcaaca tcaaagccac aatcagagca agcacaccaa agagagcaaa aatagccatc
    10561 ggcaacgtgt aatcataagt ctgtgcaccg tctactaccg gacctttgca ataagtattc
    10621 aacacccatc cgatcaacaa aggaacaccc atcaatcccc agttctgtac ccagaaaatc
    10681 aatgcatatg cggtacccaa ctgtttttcc ggaataatct tcggaacaga cggccacata
    10741 gctgaaggca ccaacgagaa ggcaaatccc aatataatca tgatgatagt agcaaaccac
    10801 catatattca gtataggcag agcaaacatc gtatgcacaa aaataagcat cactgatccg
    10861 attatcatca atgtggctcc cttaccaata cggtcataaa gcgagccgaa caacggagtc
    10921 aggataatcg caccaatcgg caacaatccg ggaatcgttc ccgccaactt cggatctacg
    10981 ttatacttct gcaccatcaa gtcggcagca tacttgataa aggggaatac agccgagtag
    11041 aacaatacac atagtaatgc aatcagccag aatcctttat tggtaatgat atacacaata
    11101 tctttcatac ggaacggctc ttccggctcc aatccttctg catccaaaga agcatccaac
    11161 ttcttatcat agaaagtata aaggaagaaa gcaatcgtac ccacgcacaa cataatcaga
    11221 caaaacaaaa tcggagcagg aatattggta tgaaatgtgc cactctcatc cgtagatccg
    11281 aaaaagtcgg ccaaaggaac cgtgagcacc attgccagag ttgttccgat acgtgccgta
    11341 gccatttcaa gtcccatagc caatgccatt tccttaccct tgaaccattt cacgataatt
    11401 ttggaaactg tgataccggc aatttccaca cctacaccga agatagcata ccccaatgca
    11461 gccagggtta cctgtgtttt gaatccgaag agcatggcac cttccggaaa agtagtagaa
    11521 atcgcatagt atttcaatcc acaaccaaac accatcaata agcaagctcc cattccggta
    11581 aaacgaactc ccatcttatc caaaatgata ccaccgaaaa tcagcatcaa taggaataca
    11641 ttaaaccacc cgtaagcact tgtgaagaaa ccataatcaa gactgtccca tagtagttct
    11701 ttctcaagca tgggttttag aggagacatt acgtcggtga ggaaatagcc gcatagcata
    11761 gtaaatgcga ccaatgctag aacactccat cggagtacgg cggagtcatt caatttctgt
    11821 ttcaaatgtt ctgtcattgt tatatttaaa aatagtagtt aataatcttc atacgaccaa
    11881 caaaggtagt taaatctcgt ttgtttctat caaaaagaga ttgtttttac aagaaaaagt
    11941 taagtgcgga ttacactgac cacgcggaag attgaaaatc cgtgtaatct gcgtaatccg
    12001 cacttaaata tcaaagaaat gcagcatccg tctgcacctt cccattaatg gttttacccc
    12061 aaagtcttac ctgacaacgg agtgaattac tctgctgcag gagcaggagt ttcagtagcc
    12121 ggtgccggag tttctgtagc aggtgcattg gtagcaggag cttcagtttg cggcgcagcc
    12181 gtacctgcgg gtaagttata cgggttagtc tgttgttctt tctgtgcctg ttccaacact
    12241 gcgtctttag caacagcaga gcgaggaact acataagcag tagcaatgct cattaccacc
    12301 atgaagatag ctaagcccca tgttgctttt tccagaaaat ctgtagtctt gcgcacgccc
    12361 atgatggcgt tagatgaaga gaaaccagaa gcaagtccgc ctccttttga gttctgaatc
    12421 agcacgatga aacacatcaa caaggctgca ataaccatta agataacgaa taataagtac
    12481 atttttagtt attttgaatt agcgttaata atcaatttct ccaaaaatct gatttggtct
    12541 gcaaagtaag catttttttt tggatatttc aagcttaatt ttttaattat ttcaagagct
    12601 tttgaatatc gttgctgttt aacatagatt tttgccaaag tttccgtaaa acagctgtca
    12661 tcttcctctt cttccttcat cgtttcttct tcggtaagtt cgtccgaaga ggttggcgaa
    12721 gatggcattt cttctcttaa aggtttcttg cagaggggag agtcgctctc gctcttttct
    12781 ataaagtcgt caatcagttc gtagcctttg agtttgggcg tttcttcggc cggctgttcc
    12841 gtggccggag tctcctccaa aagataagag gtgtaatcca tcgaatagtc gaagctggtg
    12901 cgggcagtca cctcttcggg tactgtggac aagaaagcgt cgatcaatgc taatgtgcgg
    12961 tctacggacg gttcgtcttt cagcacctcc gtgagaggta ctcccttttt ccgtgcctgc
    13021 acatcatagc ggtcaccttc aatcaaccgg aacaactgcc gtctgtctgc aatgtaaaga
    13081 actgctttcc gcagttctcc accaaaacta atatcatgga gaatatacag attcttcaga
    13141 tacagcagac gaagtgactg aaaatacgga tacctcgcaa gaagattgcg cagttcgtac
    13201 aaagtatccc tattcagcgt ctcgggatgc tgaatccatt gttgaaagtt aacagaagtc
    13261 atttatatta ccagtttgct acagttgcat taaaaatttg gtcggtgatc tctttagaca
    13321 tttcagcaat caatccgtcc tgtacggcag tcagcaactg gctagagtcg taggtacgga
    13381 acgcagaaaa ctgttgttca aagtcttcgg catgattggt gttgttgaca aaacgtacat
    13441 taacggtgat agtcaacttc gtctccgaag aataaccgtc ggcagataca gcctgattgt
    13501 actgattgta acctgtgatt tctccgtcaa tctgcaagtc ggcattttga ctcggcttga
    13561 gcagttgcag acgggtctgc cggatgaaga tatctttcag gtcctcatta aacttggttg
    13621 ccaacggagc atacacatac tccgacttga tcgggaagtc ggctatcgaa atggtcttta
    13681 ccttatcata attgatagac gatccgttaa acttatagga aacagtgcac gcaatgacta
    13741 ccaacggcaa gccgaacagt aacaaagggc gtattatttt cttaatccaa ttcatattct
    13801 tttatttttc tatagagtgt acgctcggaa atattcaagt ccttggccgc actcttccgc
    13861 tttccatgat gcctctcaag tgctttgcgt atcatttctt tctccacttc gtccagtgac
    13921 aaaggagatt cttctacata ttcttccgtg tcttgtatgt catcatcatc cttgcaaacc
    13981 gtgggctgca tggtgtgaat gatagcaggt accgaaggct ggtgtgtcgt cactaccgga
    14041 gtagtaacca ccgttcccac ttgtcctacc tgccccacct gtccggcacg ttccgccatc
    14101 aggttgtgca ccatcttctt cagctccgcc acttcctggc gcatatcgaa cagaacagaa
    14161 taaagaatct cccgttcgct ctcaaagcct ttactctcac gcgttcccat cagcgcggga
    14221 agacgttgcg tattttgtgc aggaagataa ttctgcaaga tagcagcaga gatctccctg
    14281 ttggtttcaa tgatagatat ttgctcggtg atgttcttca actgacgaac gttgccgggc
    14341 cacgggtaag ccaataactc tttcttcgca tcctccgtca actggatagc aggcatccgg
    14401 tatttctctg caaagtctgc ggaaaactta cggaacaaca aaagtacatc gtcaccacgt
    14461 tcacgcaaag gcggtatttg gataggcacc gtattcaacc ggtaatatag atcttcacgg
    14521 aaacgtcctt ctgcaatcgc ttgtgtaaga ttgacgttgg tagctgccac cacacgcaca
    14581 tccgtttttt gtactttgga cgaacctact ttcataaact cgccactctc cagtacacgg
    14641 agcaaacgtg cctgggtaga catcggcaac tcccctactt catcaagaaa aatagtaccg
    14701 ccatcggctt cgccaaagta ccctttccgt tcgccaatcg caccggtaaa cgcacctttc
    14761 tcatgtccga acagttcgga atcaatcgta ccctccggaa tagcaccaca gttgacagca
    14821 atatactgtc cgtgcttcct ccggctatat tgatgaataa tctgcggaaa actttctttt
    14881 ccgactccac tttctccggt aatcagcaca gacaaatcgg taggagctac ctgaatggca
    14941 acatctatgg cgcgcgacaa tgcttcagta tttccaataa taccgaaacg ctgtttcact
    15001 tgttgtatct ctgctctcgt catcactcgt ttttaatctt cgtctactgt atccagcttc
    15061 agtttatcac tatcgtcacg tttctcgtaa tactgtttac gcaacggatt ggcacgagcc
    15121 actttttccc gctgacgatt acggaacacg tcgatggcaa catagattgc ctgacggaaa
    15181 gaatcttcac aagccactcc cttacctgca atatcgtatg ccgttcct
//
