LOCUS       gnlProkkaJKHPGLFC_11   11128 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JKHPGLFC_11.
ACCESSION   gnlProkkaJKHPGLFC_11
VERSION     gnlProkkaJKHPGLFC_11
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 07:16:41
            Original ID  :: gnl|Prokka|JKHPGLFC_11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11128
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11128
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1863:6128]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1864..6128
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11128
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11128
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             85..570
                     /locus_tag="ctg11_1"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             567..1850
                     /locus_tag="ctg11_2"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             1864..2562
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 6.7e-13, bitscore:
                     44.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             2582..3883
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 213.9;
                     E-value: 4.7e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_4"
                     /sec_met_domain="CTP_transf_like (E-value: 1.4e-11,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9.7e-121, bitscore:
                     397.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 4.2e-63, bitscore:
                     208.2, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVYESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             3895..5031
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 8.6e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.8e-19, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             5028..6128
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 3.2e-33.
                     Score: 107.0. Matches aSDomain:
                     nrpspksdomains_ctg11_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 79.4; E-value:
                     4.2e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_6"
                     /sec_met_domain="Aminotran_5 (E-value: 2.4e-29, bitscore:
                     97.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLLVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAVLKY"
     aSDomain        5118..5906
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg11_6_Aminotran_5.1"
                     /evalue="3.20E-33"
                     /label="ctg11_6_Aminotran_5.1"
                     /locus_tag="ctg11_6"
                     /protein_end="293"
                     /protein_start="30"
                     /score="107.0"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLLVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             6148..7641
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_7"
                     /sec_met_domain="Polysacc_synt (E-value: 2.3e-09, bitscore:
                     32.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKKNVVKWNFVFYLLEFLYTILVGIILVPLYLKYIPKDLYGFW
                     LATGNILSILTLINPGFSDVIQQKVAYCYGLHDYKKIGLYTVSGICLTFVFSLIVLIIG
                     VVVNLLIGSIFTMQANYLYELKIAFGLMLVGTFLTINYYSFSSILYAFLSSKSIGLIVL
                     LGNSLGTLISIYLIIHGYGLIALGIASVVRGGVFLSCSVGYVIFKFRKKKIKIVFDLNN
                     VKEIFSFSIYNFLGKTGQTLLTNMNSFLTAKFVSPIDAANLRFTQTVPEFGKVLVLRFL
                     YSVAPIIPNLLAAKGLESIRIKLLNIVYFLISFIFLVCIGFYLLNEQFIYLWLGENNFS
                     GKIINFFIIILLFFSSINKVCFQFLFALGDIKKSNKILFYQSLLYLPIAVFTTKFCGII
                     GLLLSGILVELLALFIFFFPKMVDILNISKIDIRKKLFVELTKISFVTVITLLIGSCVK
                     FSNPSWLLFFVEIVFIVLTFFVLLFLCSKTFRNLLSICK"
     CDS             7645..8790
                     /locus_tag="ctg11_8"
                     /transl_table=11
                     /translation="MKILLVFIDMIRVDHLSLYNDNMEKTSLDLFFENLGGTILTNCYT
                     PAPDTPRSIACLQSGLLPYLNGCDSRVKWPRYFMKPNIETIFDIAVGLGYKVNLCATKS
                     DIETGLFKFKENENISIFTTIEDFTDTVHLSENTLSLIAIDDYHSAIDDYGGTSLGIKE
                     GQKVILYSLNNFLTPDIVNKYDYSFFFSDHGHALQSEIVMQKNKLELLSDGRTKLFMFY
                     HNINNKKIVKDSRLASILDLYASIVDLIGSGDFRQGFSFFRDSQRDILHIEDHADFRVS
                     PEQIVSQWRVISDEIDIRTNVFETLNKKGQIIDINVVKKYLDSFSPSFSYYMKQIEILK
                     MYEKMKQRKTHYFNGVKRANWWIRCYVRIINRLYILINRLK"
     CDS             8787..9656
                     /locus_tag="ctg11_9"
                     /transl_table=11
                     /translation="MIVSSLRGGLGNQMFIYAMVKAMALRNNVPFAFNLTTDFANDEVY
                     KRKLLLSYFALDLPENKKLTFDFSYGNYYRRLSRNLGCHILHPSYRYICEERPPHFESR
                     LISSKITNAFLEGYWQSEKYFLDYKQEIKEDFVIQKKLEYTSYLELEEIKLLDKNAIMI
                     GVRRYQESDVAPGGVLEDDYYKCAMDIMASKVTSPVFFCFSQDLEWVEKHLAGKYPVRL
                     ISKKEDDSGTIDDMFLMMHFRNYIISNSSFYWWGAWLSKYDDKLVIAPGNFINKDSVPE
                     SWFKLNVR"
     CDS             9664..10716
                     /NRPS_PKS="Domain: NAD_binding_4 (4-199). E-value: 6.3e-12.
                     Score: 37.0. Matches aSDomain:
                     nrpspksdomains_ctg11_10_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     300.8; E-value: 2.1e-91)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_10"
                     /sec_met_domain="RmlD_sub_bind (E-value: 6.1e-16, bitscore:
                     53.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 7.5e-13,
                     bitscore: 43.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVLVTGAAGFIGSHVCKRLLQRGDEVVGLDNINSYYDINLKYGR
                     LSSLGVPQSELSWYKFTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFDVVINLAAQAGV
                     RYSIENPYAYVESNIDGFLNVLEGCRHSQVKHLVYASSSSVYGLNGQVPFSEKDGIAHP
                     VSLYAATKKSNELMAHTYSHLYNIPSTGLRFFTVYGPWGRPDMSPFLFADAILHGRPIK
                     VFNNGNMLRDFTYIDDIVEGVLRVADSIPEGNQCWDAEVADPSMSCAPYKIYNIGNSRP
                     VKLMDFIRAIEMSIGREADKIYLPMQPGDVYQTYADTSSLSREIGFQPNTSLEAGVKKT
                     ISWYKEFYNL"
     CDS_motif       9673..9735
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg11_10_0001"
                     /evalue="2.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg11_10"
                     /protein_end="24"
                     /protein_start="3"
                     /score="13.9"
                     /tool="antismash"
                     /translation="LVTGAAGFIGSHVCKRLLQRG"
     aSDomain        9676..10260
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg11_10_NAD_binding_4.1"
                     /evalue="6.30E-12"
                     /label="ctg11_10_NAD_binding_4.1"
                     /locus_tag="ctg11_10"
                     /protein_end="199"
                     /protein_start="4"
                     /score="37.0"
                     /tool="antismash"
                     /translation="VTGAAGFIGSHVCKRLLQRGDEVVGLDNINSYYDINLKYGRLSSL
                     GVPQSELSWYKFTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFDVVINLAAQAGVRYSI
                     ENPYAYVESNIDGFLNVLEGCRHSQVKHLVYASSSSVYGLNGQVPFSEKDGIAHPVSLY
                     AATKKSNELMAHTYSHLYNIPSTGLRFFTVYG"
ORIGIN
        1 gacattagtt ggaggcttca gattgtcccc atatctgttt tgataacctg aaatgaatcc
       61 actatgaata atgtaggtta agttatgaat acactcactt ctcaaattga acaattacag
      121 agtctcgcgc acgagttact ctatttaggt gtggatggtg ctcctattta taccgatcat
      181 ttccgtcagt tgaacaaaga agttttagaa caatccgatg cgttgtatcc tcagcgtggt
      241 gctactcccg aagaggaagc aaacatctgt ctggcattat tgatgggtta caatgcaacc
      301 atctataatc agggtgacaa ggaggagaaa aagcaagttg ttctcaatcg ttgttgggac
      361 gtgcttgacc aacttcctgc tactttattg aaatgccagt tgttgactta ttgttatggt
      421 gaggtgtttg aagaggagtt ggcgaaagag gcgcatacta tcatagaaag ttggagcaat
      481 cgagaacttt taaaagctga aaaagaaata gctgaaagtt tgaataattt ggaagctaat
      541 ccttatccgt acagcgaact acacgaatga ttcgttcctt tctttcccgt tctccccttt
      601 acgttttggc tctctatgcc agcgttttga tttttctggt ttatacttgt gcctatgcct
      661 accgtaagcc atttaccgca gccatttatg aaggtgagat tctttgggga ttcgatgtca
      721 aaatcctgta tgtcctttct gagattatcg gctacgccct ttccaagttc atcggtgttc
      781 gtattctgcc ttcgatgaaa gcgggtcacc gcatctatta tataataggg ctgcttactt
      841 tttccgaagt tgctttgttg ggttttgcac ttcttccggt tcctttgaag gtgtgttcta
      901 tttttctgag cggtcttccc ctgggtatga tctggggtgt catttttagc tatatcgaag
      961 ggcgtcgtat cagtgaaata ttgaatgtcg ggctgagcgt tgctttgata gtctcttccg
     1021 gtttggtgaa aaccttggga caattcgtga tggataattt gcatgtgtcg gaatattgga
     1081 tgccttttac caccggtttg ttggtatacc ctgttatgtt gctttgcagc tggcttctca
     1141 atcagattcc ggctcccaat gagcaagata tcatacagcg taccaaacgt gctccgatgg
     1201 atggtaaaga caggcgtaaa tttttgaggc aattcttctg gggaatctgc atgctggttg
     1261 ttttttacgg tgccctgacc gtgttccgtg agcttcgtga ctctttcgct gccgatattt
     1321 ggaaggagct ccatattgag ggtgcaatga tctttactca gacagaggtt cccattgccg
     1381 tttttgtcct tgtactgatg ttcctgattg tgtttgtccg taataaccgt ttggctctta
     1441 atatcattta ttgcattgcc gtcacaggcg gttccttaat ggttttttcc acattgcttt
     1501 atgtgtacgg ttttctttct cctatttggt ggatgattct ttccggtctt ggtctgtata
     1561 tggggtatat tcctttcact tacctgatag aacgtctgat tgcttccctt agggtggtta
     1621 gtacggctgt ttttattatt tatttggccg attctttcgg ctatctgggc actacgggtg
     1681 tgtttatggt caagaacttc gtttctgctg atatttcctg gactgtcatg ctgatgcgta
     1741 ctgccctttt ttcaggattt gtttctgtcc tgtcgatttt tgcgatttac tgttatttca
     1801 agcaacaatt gaattcactt atattaattc cctctgaaat tcatgattaa aacagcaatg
     1861 atcatggctg ccggtcttgg tacccgcttc gggcattata ccgagcttgt gcccaaaggt
     1921 tttgtggagg ttggtggaaa acctatgatt atccgctcta tcgaaaccct tctttcctgc
     1981 ggtatcgaac gtatcatcct cggtacgggt tataaaaaag aggcttatga ggcccttcag
     2041 gcggatttcc cccagataga gacctgtttc agtccccgtt atgccgatac taacagtatg
     2101 tacactctgt acaatacgcg tgacgtgata ggcgatgaca gtttcctgct gcttgaatcg
     2161 gaccttgttt ttgaacgcaa ggccatcctt tcgctgctgg atgacgaatt cccggatgtg
     2221 atgcttgtct cttctctgac caagttccag gatcagtatt atgtggaata tgaccgcaat
     2281 cacatcctta cttcctgttc ggtagacaag aacgcccttg aggcaaaagg cgagctggtc
     2341 ggtatccata aactttccaa tactttctac cgccggatgt gcgccgatta tgcgaccatc
     2401 ctggagtccc agcctaaact gggttacgaa tacgaactgc tccgcatgtc ccgttccgtt
     2461 tcccctgtcc gtgtgctcag ggtggagggt cttaaatggt atgaaatcga tgatgaagcc
     2521 gacctttcgt atgccgagga gcacatcatc cgctattgtt aaaaacaaat cttttccata
     2581 tatgaacaag aaaatctatg tcggtatgac cgcggatatc atgcatccgg ggctgatcca
     2641 tattattcat gaagctacta aatacggtga tgtcatcgtc ggtctgctga cggacaaggc
     2701 catcgccgaa cacaaacgcc tcccttacct tacctatgat cagcgtaagg aggttgttga
     2761 gaatatcaag ggggtttgcg aagttgttcc ccaggaggat tggagctatg ttccgaatct
     2821 ggaaaaactc aagcctgact atatcatcca cggtgacgac tggaaaacgg gtccgttgcg
     2881 cgaggtgcgc gaacaggttt ttgaggtgat gaacgcccag gggggcaagg taatcgagat
     2941 cccttatacc cggggcatca actcctcctc gctcgacaag gatatcaagg cgatcgggac
     3001 tacccctgac gtacgtctta agtccctccg ccgcctgatc caggccaagc ctgtggtccg
     3061 tatcctggag gctcacgacg gtctttgcgg tctgattatt gagaatcttg aagtccagaa
     3121 gggtgataag cgcgaggtct ttgacggcat gtggtccagc agcctgaccg actccacgag
     3181 taagggtaaa ccggatattg aagcggtcga ccttaccacc cgtttacagg acctgaacaa
     3241 tatccttgaa tgtaccacca agcctattat ttttgatgga gacacgggtg gcaagatcga
     3301 acactttgtc tttactgtgc gcactctgga acgtcatggc atttctgcgg taatcattga
     3361 agataaagtc ggtctgaaga agaattccct ttttggtact gacgctatcc agactcagga
     3421 tagtatcgag ggtttctgcg ataagatcag agcagggaag aatgcccagg tcaccggtga
     3481 ctttatgatc attgcgcgta tcgaaagcct tattgccggc aaacccatga gtgacgccct
     3541 cgaacgtgct tatgcctatg tacaggcggg tgcggacggc atcatgatcc acagcaagga
     3601 taagtcgggt gaggatatcc gtgagttctg ccggactttc cgcaaagaat acgcccatgt
     3661 tcccattgtc gttgttccga cgacttatga ccatgtgtac gaatccgaac ttcacgaatg
     3721 gggtgccaac gtagtcattt acgccaacca ccttctccgt gccgcttacc cggccatgat
     3781 gaacgtggcc aggaccatcc ttgaaaacga gcgcgccgag gaggtccgtc cgctttgtat
     3841 gcctatcaag gaaattctgg aattgattcc gggcactaaa taaatcagac ggttatggta
     3901 agtgtagaaa agatatacga tacgttcctt catcacggtg ttgacttctt tacgggtgtt
     3961 cccgattccc ttttgaagaa tatttgcgcc tatatcacgg atcatgctcc gcgtggtaag
     4021 catatcatcg ccgccaatga aggttccgcg gtgggcattg cctgcggtta ttatatggct
     4081 tctggcaacg ttcctttggt ttatatgcag aactccggtc tgggaaatac ggtgaatccc
     4141 ctcttgtccc ttgcggacga gaaagtgtac agccttcctc ttcttttgct ggtcggctgg
     4201 cgcggtgagc ccggcacaaa agacgaaccc cagcataaga agcagggcga ggttaccctt
     4261 gatcttctga aagccatgaa aattcctttt ataattctgg atacggatga agacgaggcc
     4321 ctggcgcaga tccatgacgc ggttgtctcg gcgaagagcc ggtcgattcc ccatgcgatt
     4381 gtcatccgta aagatacgtt tggaaaatat aaattgcgtc aggaagcctt gaatgactat
     4441 cctctgtccc gcgaggaggc gctaatgcag gttgtcgacc acctcgggga caatgacatt
     4501 gtggtttcca ccacgggcaa gctctcccgt gagcttttcg agtaccgtga atcgaaaggg
     4561 caggggcacg caagggattt cctaactgtg ggttccatgg gtcacagttc ttccattgcc
     4621 ctggggattg cccttgagaa gcctgaccgc cgtgtctact gtcttgacgg tgacggtgcc
     4681 tttatcatgc acatgggtgc tgtcagcaat atcggcgatc tttctcccaa gaattacagg
     4741 cacgtccttt tcaacaatgg tgcccatgaa tctgtcggcg gtcaacccac gctcggtttc
     4801 cgtctggata tcgcctcgat agcgaaaggt tgcggttatg cgcatgtact gactgcctcc
     4861 gacaaggaag ggctttcgtg tgcgcttgag aagctgtccg gcctgtccgg cccggttctt
     4921 cttgaaatta aggtccggat cgattcacgt gatgatctgg gtcgccctac gactactccg
     4981 gtagagaata aagagcattt tatggcattt ttaaaagata cgcattcatg aatatcgaaa
     5041 gaaagatcct tttgaatccg ggtcccgcca ccacgacgga tacggtaaag ctggcgcagg
     5101 ttgttcccga tatctgtccg cgtgagaaag agtttgcggg tatgatgaaa cagttacgtg
     5161 acgacctggt ccgcgttgcg catggagacc tctccaaaca tacggccgtc ctgttttgcg
     5221 gctcgggtac gatcaatatc gatatctgcc tgaactctct tcttcctgcg gataagaaag
     5281 ttctggttgt caataacggt gcctatagca cccgtgcggt ggaagtctgc gaatattacg
     5341 gtcttcccca tatcgatttg aagttttccg tttacgaact tcccgacctg ttggtaatcg
     5401 aaaagacgct ttccgacaat ccggacatcg ctttggtcta taccacgcac catgaaacgg
     5461 gtacgggtat cttgaacccc atccgtgaga tcggaaaaat agcccattcg cacggtgccg
     5521 tttttgttgt cgacaccact tcctccctgg gtatgattcc ttttgatatc gggaaggata
     5581 atgttgactt ttgtatggct tcggctcaga aaggccttca ggccatgacg ggtctttcct
     5641 ttatcatagg tgatgaatcc ctgatacgtg cttcaaggga ttatccgaaa cgctcctact
     5701 attgtaacct ctatttacaa tacgattact ttgagaagac gggtgagatg cattttactc
     5761 ctcctgttca aaccgtttac gctgcccgtc aggctcttga tgaatatttt gcagtaggtg
     5821 aagaggctaa attcgcccgt cacaagaggg tctttgaagc catccataaa ggtttgcaag
     5881 agcttggtct tcagtatgcg atcaaacgtg aatggcagtc gggtcttgtt gtttctgtat
     5941 tgtatcctga tgatcccctc tgggattttg ataaggttca tgattactgc tatgaacgtg
     6001 gctttacgat ctacccgggt aagatttcca caacgaatac attccggctt tgtgcgttgg
     6061 gagagattga tgtggaggat attgagaggt tctttgaggt gatgagggag gctgttttaa
     6121 aatactagag aaattgtcaa ttgggatatg aaagataaaa aaaatgtagt aaaatggaat
     6181 tttgtatttt atctcttgga atttttgtat acaattttag ttgggattat tttggttccg
     6241 ttgtatttga aatatattcc aaaggattta tatggtttct ggctagctac tggtaatata
     6301 ttgtctattt taactcttat caatcctggg ttttcagatg tgatacaaca aaaagttgca
     6361 tattgttatg gattacatga ttataaaaaa ataggattat ataccgtttc aggtatttgt
     6421 cttacgtttg ttttttcatt aattgttttg ataatcggag tagtagttaa ccttttaata
     6481 ggtagtatat ttacaatgca agctaattat ttatatgaat taaaaatagc ttttggctta
     6541 atgcttgttg gtacattttt aactattaat tattattcct tttcttctat attatatgct
     6601 tttcttagta gtaagtcaat cgggctaatt gtacttctag gcaatagttt aggtacttta
     6661 atatctattt atcttattat ccatggatat ggtctaatag ctttgggaat tgcatcagtt
     6721 gttcgaggag gtgttttttt gtcatgtagt gttggctatg taatatttaa atttcgaaaa
     6781 aagaaaataa aaattgtatt tgatttaaat aatgttaagg agatcttttc tttttctata
     6841 tataattttt taggtaaaac aggacaaaca ttgttgacta atatgaattc tttcttgact
     6901 gctaagtttg tttctcctat tgacgctgca aatttgagat ttactcaaac tgtgccggaa
     6961 tttggtaaag ttttagtttt aagattttta tattctgttg ctcctattat tcctaatttg
     7021 ttagcagcta aggggttgga gtctattaga ataaagcttt tgaatattgt gtattttttg
     7081 atttccttta ttttcttagt atgtattggt ttttatctat tgaatgaaca atttatatat
     7141 ttatggcttg gtgagaacaa tttttcaggg aaaataatta atttttttat cattatttta
     7201 ttgttttttt cttctataaa caaggtctgt tttcagtttc tttttgcatt aggagatata
     7261 aagaaaagca ataagatttt attttaccaa tctttgttgt atttacctat tgctgttttt
     7321 acaacgaaat tttgtggaat aattggttta ttgttatctg gaatattagt agaattattg
     7381 gcactattca ttttcttctt tcctaaaatg gttgatattc ttaatatttc gaaaatagat
     7441 attagaaaga aactttttgt ggagttaacc aaaatatctt ttgttacggt tattacatta
     7501 ttaataggtt cttgtgtcaa gttctctaat cctagttggc tacttttctt tgtggaaatt
     7561 gtttttattg tattaacatt ttttgttttg ttgtttttat gttcaaagac ttttcgtaat
     7621 ttattgtcta tttgtaaata aaagatgaag atactactag tttttataga tatgatacgt
     7681 gttgatcatt tatcattata taatgataac atggagaaaa catcgttgga tttgtttttt
     7741 gaaaatttag gaggtacaat tctaactaac tgttatacac ctgcacctga tactccaaga
     7801 agtatagctt gtttgcaaag tggcctatta ccctatttga atggctgcga tagtcgtgtc
     7861 aaatggccaa gatattttat gaaacctaat atagaaacta tttttgatat tgcagtaggg
     7921 ttaggatata aagtaaattt gtgtgcgact aaatctgata ttgaaacagg gttgtttaag
     7981 tttaaagaaa atgaaaatat tagtatattt actactattg aagattttac tgatactgtt
     8041 catttgtcag aaaatacatt gtccttaatt gccattgatg attatcattc tgccattgat
     8101 gattatggag gaacctcatt gggaattaaa gaagggcaga aagtgatatt atattcttta
     8161 aataattttc taactccaga tatcgtaaat aaatacgact attcgttttt cttttcagac
     8221 catgggcatg ctttgcagag tgaaattgtc atgcaaaaaa ataaactaga actacttagt
     8281 gatggaagaa ctaaactttt tatgttctat cataatatta ataataagaa aatagtaaaa
     8341 gattctaggc ttgcttctat tttggatctt tatgcctcta ttgttgattt gattggtagt
     8401 ggagatttta ggcaaggttt ttcctttttt agagacagtc aaagagatat acttcatata
     8461 gaggaccatg ctgattttag ggtgtctcca gagcaaattg tgagtcaatg gcgagtaatt
     8521 tcagatgaaa tagatattag gactaatgta tttgaaactt taaataaaaa aggacaaata
     8581 atcgatataa atgtggtaaa aaaatattta gatagttttt ccccctcgtt ttcttattat
     8641 atgaaacaga tagagattct aaaaatgtat gagaaaatga aacaacggaa aacgcattat
     8701 tttaatgggg taaagcgagc taattggtgg atccgctgtt atgttagaat tataaatagg
     8761 ttatatatac taataaatag attgaaatga ttgtatcatc tttgcgagga ggattgggga
     8821 atcaaatgtt tatttacgct atggtgaagg ccatggcatt aagaaacaat gtaccattcg
     8881 cttttaattt gactactgat tttgcaaatg atgaagttta taaaaggaaa cttttattat
     8941 catattttgc attagacttg cctgaaaata aaaaattaac atttgatttt tcatatggga
     9001 attattatag aaggctaagt cgtaatttag gttgtcatat acttcatcca tcatatcgtt
     9061 atatttgcga agagcgccct ccccactttg aatcaaggtt aattagttct aagattacaa
     9121 atgcttttct ggaaggatat tggcagtcag aaaaatattt tcttgattat aaacaagaga
     9181 taaaagagga ctttgtaata caaaaaaaat tagaatacac atcgtatttg gaattggaag
     9241 aaataaaatt gctagataag aatgccataa tgattggggt tagacggtat caggaaagtg
     9301 atgtagctcc tggtggagtg ttagaagatg attactataa atgtgctatg gatattatgg
     9361 catcaaaagt tacttctcct gttttctttt gtttttcaca agatttagaa tgggttgaaa
     9421 aacatctagc gggaaaatat cctgttcgtt tgataagtaa aaaggaggat gatagtggta
     9481 ctatagatga tatgtttcta atgatgcatt ttcgtaatta tataatatcg aatagctctt
     9541 tttactggtg gggagcatgg ctttcgaaat atgatgataa gctggtgatt gctccaggta
     9601 attttataaa taaggattct gtaccagaat cttggtttaa attgaatgta agataaaatc
     9661 ttaatgaatg tattagtaac cggtgctgcc ggatttatag gttcgcatgt ttgtaagcgt
     9721 cttttgcaac gtggggatga agttgtgggc ttggataata ttaattcgta ttatgatatt
     9781 aatttaaagt atggacgcct ttcgagctta ggtgttcctc aatctgaact gtcatggtat
     9841 aagttcacac ggagtaatgt ttatcctcga tttagttttg tgcggatgaa cctcgaggat
     9901 aggcaggcta tgcaaatgct gtttgctaat ggaaattttg atgtagtaat caatttggcc
     9961 gcacaagcgg gagtgcgcta ctccattgag aatccatatg cttatgttga aagtaatata
    10021 gacggttttc tgaatgttct cgagggttgt cgtcacagtc aggtgaaaca tttggtttat
    10081 gccagttcca gtagtgtata tggtttgaat ggacaggttc ctttttcaga gaaagatggc
    10141 atagcccatc cggtgagtct gtatgccgca accaagaagt cgaatgaact tatggcacat
    10201 acttatagcc atttatataa tataccttct acgggtcttc gtttcttcac ggtatatggt
    10261 ccctggggta gaccggatat gtctcctttt ctatttgcgg atgctatctt gcatggtcgc
    10321 cccatcaagg tctttaacaa tggcaacatg cttcgtgatt ttacatatat agatgacatt
    10381 gtggaaggtg tcttgagagt ggctgattct attccggaag ggaatcagtg ctgggatgct
    10441 gaggttgcgg atccaagcat gtcctgtgct ccctataaga tttataatat tggtaattcc
    10501 cgtcctgtaa aattgatgga ttttatacgt gctatagaaa tgtcaatcgg gagggaagct
    10561 gacaagatct atcttccgat gcagcccggg gatgtgtatc agacctatgc ggatacttct
    10621 tctctttcgc gggaaattgg ttttcaaccc aatacgtcct tggaggcggg cgttaagaaa
    10681 acaataagtt ggtataaaga attttataat ctataattat gaagattgct atagttggta
    10741 caggttacgt cggtttggtt acaggtacct gtttctctga gatgggagta gacgtcacat
    10801 gcgttgatgt gattgaatct aaaattgata atcttaaaaa aggcataatt ccgatctatg
    10861 agccgggact tgaagacatg gtgcaccgca attacaatgc ggggcgtttg aagttcacta
    10921 cttccttagc ctcatgtttg aatgatgttg aggttgtgtt tagtgcagtt ggtactcctc
    10981 ctgatgaaga tggcagtgcg gatttaaagt atgtgcttga agttgcccgt acgattggta
    11041 aaacgatgaa ccattatgta ctggtggtaa cgaagagtac tgttcctgtc ggcacagcgc
    11101 aacaggtgaa agctacgatc cggggtga
//
