LOCUS       c00353_gnlPro..        11870 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PKKDCFKE_353.
ACCESSION   c00353_gnlPro..
VERSION     c00353_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 06:31:49
            Original ID  :: gnl|Prokka|PKKDCFKE_353
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11870
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11870
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2352:8434]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2353..8434
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11870
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11870
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(3..263)
                     /locus_tag="ctg353_1"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVA"
     CDS             378..2291
                     /locus_tag="ctg353_2"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCYEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     IGGNRILEEKIDIGIISPYKAQVQYLRSKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRTNEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRRLLEFIQNIG
                     NQ"
     CDS             complement(2353..3396)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg353_3"
                     /sec_met_domain="IlvN (E-value: 3.9e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.5e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(3447..4199)
                     /locus_tag="ctg353_4"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(4196..4756)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg353_5"
                     /sec_met_domain="ALS_ss_C (E-value: 6.1e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             complement(4789..6540)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg353_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(6632..8434)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg353_7"
                     /sec_met_domain="ILVD_EDD (E-value: 2.4e-219, bitscore:
                     718.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAAKLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILAGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             8924..9496
                     /locus_tag="ctg353_8"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDVVVMDMNHPLAGCDLNFTGEVVESRPATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
     CDS             complement(9604..10884)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg353_9"
                     /sec_met_domain="SDH_alpha (E-value: 5.9e-63, bitscore:
                     202.3, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETERLQIIALVKNEVVPAIGCTEPIAVALCVAKAVEVLNKRPE
                     KITVLLSANILKNAMGVGIPGTGMIGLPIAVALGALIGKSVYQLEVLKDSTPDAVEAGK
                     RFIEEKRIHISLKDDIEEKLYIEVCCEADTDKATAIIAGGHTCFTYITHNGDILLDKQT
                     ASCIEEEEDVLDLTLRKVYDFAMTTPLDDIRFILDTARLNKTAAERSFEGEYGHGLGKI
                     LRGTYEHRIMGDSVFSHILSYTSGACDARMAGAMIPVMSNSGSGNQGISATLPVLVYAE
                     ENGKSEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGTYEQVA
                     YAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAIMAMENRCVTSVEGIIDEDVDQ
                     SIRNLTKIGSKGMNETDKLVLEIMTSK"
     CDS             complement(11006..11869)
                     /locus_tag="ctg353_10"
                     /transl_table=11
                     /translation="YAPGRLTWVSPYGEGGNAGIAADNISTVGTNVLSAAMIQLLKDVE
                     FKADGSIVASYAEEINITMDQMIMAGMGQLPSTDGIVWKTSPTNLAYWYVKGEHIYVVL
                     NIPAIVTEALKDAEDSQMTPEAVLQIIEMVKSMSGADIKNLLGQLLAGLEDDNMLKKLD
                     ISKISDSDIEKLISYVIDGFPLNYRTTQLEIKNEEELVRTVNDLSIYLDKDLFDIFMPA
                     LYPMLPDVDALLKNTNIELWGQSIPLWNMIQMLTALNSMTEIEGIWNVTTRFNLGISLG
                     DNSYKK"
ORIGIN
        1 acggcaacct gctcacggcc tgcattcata aattgcaata aggccatttg agccgttgca
       61 tcctgcatgg ccacacggtc gggacggaaa ttcacatagt cttctccccg tctgtagttc
      121 ttcactttat ccccatcata caaatgagca tacaaaattt tctctgctaa agtcatcgga
      181 cgccgcagta cgttccgtac gcgttctatc ttctccgaat aagcggcata aaacgttttg
      241 agcatcgtta aatcatatac cataaccact attttttagt ttttcattat tgtaaagatt
      301 acaaattaat atcataaaca aataaaaagg ctgaatagtt taacaaaata aagcattttt
      361 tctgtcggaa gcgaagaatg attacctttg caaccatgaa ggaacaagat tcaaatagtc
      421 ctattattca cctccagcag caacaacttt tgctgcgcat ggaatacgaa tacgaaaaag
      481 aggaattcaa acgccaaacc gaaaacatgg gggttgcccg gaaagtgaaa cggggacttt
      541 gctggtatcc tgccactccg ggacgaagtt actataattc actgaatcaa ttagtaatag
      601 aaattacaca cacagaaaat accgatatag aacataattt tgagttcggc cgtcccgtat
      661 gttttttccg ccagtctgcc gatggaaaaa taacctatat gaacttcacc gctaccgtaa
      721 gctatgccga cgagacacgg atggtagcga taatgcccgg agccggtgcc gttatggaag
      781 tgcaggaaac ggacaacctc ggcgtgcaac tttatttcga cgaaacatcc tatcggacca
      841 tgttcgaagc cttggaagat acgttacgct ccaaaggcaa ccgcctggcc gaattgcggg
      901 acatattgct gggaacctcg aaagccggtt tccgagagct ctaccccgta cggtttccct
      961 ggctgaactc cacgcaggag acagctgtaa acaaagtgct gtgtgcccgc gacgtggcca
     1021 ttgtacatgg tcctccggga accggaaaaa cgaccacctt agtggaagcc atctatgaaa
     1081 ccctgcatcg ggaaccgcag gtactagtat gtgcccaaag caatactgcc gtcgactgga
     1141 tttcggaaaa acttgtggac cgtggcgtca atgtcctgcg tatcggcaat ccgacccgtg
     1201 tcaacgacaa gatgctttcc tttacctacg agcgtcgttt cgagaaccat ccgctttatc
     1261 cggagctgtg gagcatccgg aaaaatctcc gtgaactggg cagccgtgcc cgccgtggca
     1321 gctatgacga acgcgaagga gtacgcagcc gtatgagccg cctgcgcgac cgcgccaccg
     1381 cattggaaat acaaatcaat gcagagcttt ttgatggggc acatgtcata gcctccacgc
     1441 tagtaagcag caatcaccgg ctgctgaacg gacgccgttt cggcaccctt ttcattgatg
     1501 aagcagccca ggccttagaa gctgcctgct ggatagctat ccgaaaagca gaccgcgtgg
     1561 tattggcggg tgaccactgc caacttccgc ccaccataaa atgctacgaa gctgcccgtg
     1621 gaggtctgga acgaacattg atggagaaag tggtgtccaa caaacctgcc gttgtctctt
     1681 tgctgaaagt acaataccgc atgcacgagg aaatcatgaa atttccttcc caatggtttt
     1741 ataatggcga gttggaagcc gctcccgaag tgcgttaccg gggcatcctg gactgggata
     1801 cccccatcca ctggattgac acctccgaaa tggatttcaa agaagaattt gtgggagaga
     1861 ctttcggacg cattaataag gcggaagcgg acctgctcct atcagaactg aaaatctaca
     1921 tcaaccgtat cggtggcaac cgcattctgg aagaaaaaat agacatcggc atcatctccc
     1981 cttacaaggc acaagtgcaa tatctccgca gcaagataaa ggcagacgct tcactcaagc
     2041 cttatcgcag cttgttcact gtaaatacgg tggatggctt ccaagggcaa gagcgcgatg
     2101 ttatcttcat cagccttgtc cgtaccaacg aagaaggaca gataggattc ctgaatgatt
     2161 taaggagaat gaatgtagcc atcacccggg cacgtatgaa gctggtgata ttgggagagg
     2221 cagagacgct gaaacatcac ggtttttacc ggaggctatt ggagtttatt caaaatatag
     2281 ggaatcaata ataaagaaat accccctccg gtaacaccga agagggtatt tcacctattt
     2341 atataaagct gattaattgt tttccggacg aagtttacga actgtaacag ctgtctgcca
     2401 catttcgctt tcacgcaagg ctttcaattc tgcattcagc ttctcacgat aatcgggttt
     2461 ggagttactg tcgatagaaa tctgggcttc gttgcccgac ttcacacttg catacaattt
     2521 ctgtacaacc ggcttgatgg catcatggaa cggggtcatc caatccagcg caccacgctg
     2581 tgccgtagta gaacagttgg catacatcca gtccataccg ttcttggcaa acaatggcat
     2641 caaagattga gtcaactctt ccactgtttc attgaatgct tcagaaggag tatggccgtt
     2701 ttcgcgcaat acttcatact gagccaacag taatccctgg atagcaccca tcaatgaacc
     2761 gcgttcaccg gtcaagtcgg aagtggcttc gcggatgaaa gttgtctcga acaaatatcc
     2821 cgaaccgata ccgataccca gtgcaatcgt cttgtcaaaa gccttacccg tagcatcttg
     2881 atagacggca tatgatgagt tcaagccacg cccttcgagg aacatggtac gaagtgaagt
     2941 accggaacct ttgggagcaa ccataataac atcaatatct ttaggaggaa ccacgccggt
     3001 acggtcgttc caggtaatag caaaaccatg agagaagtaa agagccttcc cgggagtcaa
     3061 ataaggtttg atagtcggcc atacagacat tacagctgcg tcagacaaca gacacatgac
     3121 gatagtacct ttctgacaag cctcttcgat gccgaacaaa gtctcacccg gtacccatcc
     3181 gtcagccaca gccttttcgt atgtcttacc cggacgttgt cctacaatca cattgaaacc
     3241 gttatcacgc aagttgcaag cctggcccgg gccttgtacg ccataaccga ttactgcaat
     3301 tgtttcatct ttcaaaatct cacgtgcttt ttccaaagga aattcttcgc gggtcattac
     3361 attctcaata acaccgccaa aattcaattg tgccattttt tgttttaatt tttatttgtg
     3421 gcttacgcca acgttgataa atttatttat ttctctgtaa atatcacttt agaacgacag
     3481 accacttcgc tgccattctt tttcacctcc acatcgtaaa cgccctcacc ggcatcatcc
     3541 atgaacaaag tcaactcatc cccataatag ctttcggcta catatgccat ttcaaaacga
     3601 cggatgcgct tctccttata catctctatc gggaacaaat caaggatatg ctcgatgtaa
     3661 cggatgctgt tcacatgccc gttaatgtca atatcactgt atttggctac caaagcagca
     3721 accggttcct ttgaggccac ctttatccgc gaaggttttt ctatcgggca aggctcatcg
     3781 caaacataat ctacaatgct gccactatga agagccagca aatctgccgg cttacgggta
     3841 ttcatgctaa tcatcgccca aacggaacgt gcatacccaa tcttcttacc ctccttatcg
     3901 atgatagcga aattacggtc tgtaaaaagg cgatagacat tctccaccca agtctgaatg
     3961 gagaaatctt cgtactgata aggcatttca tccagttcga cagccagacg ggacaatacc
     4021 caagtataat tgtcctcgtt tagagtcgcg atgccaaaac cgcggtcgct ggcatggaaa
     4081 cccgcacaat tcaacaaatg gttgcccaat actcccattg tcagccgtcc ggtaaagtcg
     4141 acatgaaacg gttcggcaac aaacttgtag gtacctatct tattgttctc gctcatcatg
     4201 attcctggtg tttactttga cgatattttg cttcacggtc tgccagatat tcattgacac
     4261 gctcaaagca gctggtcgta atggctacgc gacccgaacg gacgaactga agtacgcaat
     4321 ccaactggcg caactcctca taaagattgg ttatttcctc actcatgcca ttcttctcaa
     4381 caatggcaaa tacagcattc acctccacaa tacgggcatt gtacttacgg attactttgg
     4441 acacctccgg tttttcttcc agcgtagggg tcgttatttt ataaagggca atctcgtgct
     4501 gatagatttc atcatccgtg aaataatggg cttgcagcac atctattttc ttggtaatct
     4561 gcttggtcac cttttcaatg gtatccttgt ccgtccaagc ggtaatggta tatttatgta
     4621 cccccttgat ggaggaggcc gatacattca aactctcgat gtttatctgc cggcgggtaa
     4681 acacagccgt cacctgattc agcaaaccgg caaagttttc cgaatgaaca atgattgtat
     4741 atagtttttt atccatagat agagtaaatt ctttaatttc gcatgacttc agcattccaa
     4801 caacatctga ttgaccgaac cgcccggagg tgtcatcggc attacatttc cttcttcctc
     4861 cacacaagct tcgagcagga acggtccgtc agtcgctatc atctcgtcaa tcgcttttgc
     4921 cagctcctcg cgggtcatta ccctgcgtgc aggaatatca tatgccgaag caatcttcat
     4981 ataatccgga ttcatcatcg gagtaaacga ataacgacga ttgaagaaca tcgcctgcca
     5041 ttgacgaaca ttgcccaaga agttattgtt caacagaatc atcttcaccg gagccttttg
     5101 ttccatgatg gtacccagtt cctgcaggtt catctgcaag ccgccgtctc ccatgaatac
     5161 gcataccgtg cggtccggac gtccaaaagt ggcaccgata gctgccggaa ggccgaagcc
     5221 catagtaccc aggccaccgg aagtaacaat gctacgttcc ttgctgtatt tgaaataacg
     5281 ggcggacatc atctgattct ggccgacatc agtcaccaat atcgcctcgt tatgggtagc
     5341 ctcactcaca gcacgcacca cctcacccat gcttagcgct tttcctgccg gatgtaattc
     5401 cggacggatt accttttcct cttccacttc ctcgtattgc cggaaactgt caatccattc
     5461 ctgatggttg gcgggttcca gcaattgggt aacggcagcc agtgtctctt tgcaatctcc
     5521 caggacagca acatcggtct ttacattctt atctatttcg gcagggtcaa tatcaaagtg
     5581 gataatcttc gcctgcttgg catatgtttc caatttaccc gtcacacggt catcaaagcg
     5641 catgcctacg gcgataagga catcacattt attggtattg atattgggcc ccaggttacc
     5701 gtgcatacca agcattcctt tgttcaacgg atggttcgta ggtaatgcgg aaagtcccaa
     5761 taaagtgcat ccggcaggca ttccggcttt ctcaatgaaa gcacgaagct cttgctgggc
     5821 ttctcccagc tccacgcctt gtcctaccag caccaaaggc cgttccgcac catttattaa
     5881 ttcagcagcc ttccgtatgg cctccggctc catttcggga acgggaagat agctacggac
     5941 atagtccacc ttagtaggcg catattctgt tttctccact tgggcgtttt tagcaaaatc
     6001 cagcacgacc ggtcccggac gtccgctctt tgccacatag aaagcacgtg ccactgccca
     6061 ggccacatct tctgcacgac gaatctggta actccatttc gtgataggct gagtaatgcc
     6121 taccaagtcc acttcctgaa atgcatccgt acccaagaag ttcgtcccta cctggccggc
     6181 aatgacaacg ataggcgtac tgtcaatcat ggcatctgca atgcccgtga tagtattggt
     6241 agcacccggt ccactggtaa ccagacaaac gccaacctcg cctgatacac gtgcaaagcc
     6301 ttgtgccgca tgggttgctc cttgttcatg gcgaaccaag atgtggttca attccttccg
     6361 gtggtcgtat aaggcatcga ataccggcat gatgctccct cccggataac cgaaaatggt
     6421 ctttactccc tgatgctcca gagagcgcat caatgcttct gcgcctgtta ttagagcctc
     6481 accccgaccc tctccttggg agagggagga aaagttactc tttttattat tatcagccat
     6541 actttatcta ttcattatat ttaaaagctc aatagtagct tgaaaaattt gtttcattct
     6601 ttcctcccct cgctttcgga aaggggggct tttaatcaat cagcctcaca gcccctttgt
     6661 cagcggaact caccatactg gcatatgctt tcaatgcttt ggagacttca cggttgcggg
     6721 ttaccggagt catagggcgt gctgcaagct cttcatccgt caacttcaca ttgatagaac
     6781 ggttcggtat atcaatttcg ataatgtccc catccttaat cttgccgata ttaccaccgg
     6841 cagccgcttc gggagaaaca tgtccgatac ttagtccgga agtaccacca ctgaaacgcc
     6901 cgtcggtaat caatgcacac tccttaccca gatggcggga tttgatataa gaagtaggat
     6961 aaagcatctc ttgcataccc ggtccacctt tcggcccttc gtgagtgatg acgacgacgt
     7021 ctccactgac cacctttcca gccagaatac cgtcacaagc cgcatcttgt gagtcgaaga
     7081 ctttcgccgg ccccgtaaat ttccagatac tctcgtctac accggcagtc ttgacaacgc
     7141 aaccgtcctg agctatattt cccttcaaaa ctgccagacc gccatccttg ctgtatgcat
     7201 gttccaaatc acggatacaa ccggtcgcac ggtccgtatc gagttcctta taagacgcat
     7261 tttgtgaacc aagtaccaga ttgaactttc cggctgccgc actggagtat ttcttgattg
     7321 cctctttaca tacattagag ctggtaatac tataccggtc gattgcctct gccaacgtca
     7381 ttccatccac acggcggaca ttcgtatcga ccaatccgcc cttggcaagc tcatccatga
     7441 tggcaatgat gccaccggca cggttaacgt cttgtacatg atacttttgg gtattgggag
     7501 ccaccttgca taagcagggg gtcttgcggg agagcatgtc aatgtcgtcc atcttaaaat
     7561 ccgctccggc ttcgtgagcc acagccaaca aatgaagtac cgtattagtg gaaccgccca
     7621 tcgcaatatc cagcgtcatg gcattcaaaa atgcctcgcg ggtagcaata cttcgcggga
     7681 gtacgctctc atccccttct tcataatatc taaaggcatt ctctacaatc aacttggctg
     7741 catcctcaaa tagtttcttg cgattttcgt gagtggctac aatcgtgccg ttaccgggca
     7801 gtgccaatcc aatcgcttca ttcaggcaat tcatggaatt agcggtaaac atgcctgagc
     7861 agcatccgca agtggggcag gcatgttgct caatctgtgc cacctcttta tcgcccacac
     7921 tttcatcagc agatttaatc atggcatcaa tcaaatccaa atgctgtccg ttccattccc
     7981 cggcttccat cggaccgcct gaaacaaaca cagtcggtat attcagtctc atagccgcca
     8041 tcagcatccc cggagtaatc ttgtcacagt tactgataca aaccatagca tccgccttat
     8101 gggcatttac catatactcc acactatcgg caatgatatc tcttgaaggc agggaataaa
     8161 gcataccgtc gtgtcccata gcgataccgt cgtcaatggc aatcgtattg aactccgcag
     8221 caaaacaccc cagtttttca atctcttcct ttacaaactg gcctatttcg tgcagatgta
     8281 catgcccggg gacgaattgt gtaaatgaat tgactatagc gataatgggc ttacccatct
     8341 gttccttctt cataccattc gccgtccaca atgcacgggc tcccgccatg cggcgacctt
     8401 gtgtgctgaa cgagctgcgt aactgatgct tcattttcaa atctcctttt aatgaaaaag
     8461 cctctcccac tatagtgaga aaggcttaat aaattatctt ctaacgtacg aatacataca
     8521 taacctttct cacgctcttg atgccaccac cacgacgcga ataatatgca ggactgccag
     8581 gttaatagat gtatgtaaat tcataactta attcttcttt tttgtttcaa acgtgctgca
     8641 aaggtaaggg cttttttata atctccaaac aaattgaaga aaaaaataag ataaatatga
     8701 ataatcgtaa gaaaatatcg ccctaaaatc ctattttatc acttaacagt tctaaataga
     8761 accattcaga cagccaatgt aaatgtattg ccaatcattg aaaccattta ataatctgaa
     8821 aattaccaaa ggctctctac atcccgaaac aaataattcg tatctttgtc tcttcaaata
     8881 ctcaaaaaaa agtatttact aattaaataa agatagaaaa ttaatggaaa cagtagaaaa
     8941 caagtacatc accgtagcat ataagctgta ctcaatcgaa aacggagaaa aagatttcga
     9001 agaagaagca cccgtagagc atccttttca gtttatctca ggtctgggaa tgacactcga
     9061 accctttgaa gcccagataa aagacttgca gataggcgat aaattcgact ttaccattcc
     9121 ggcatcagaa gcttatggtg aatatgacga cgaccatgtt attgacctcc ccaaagaaat
     9181 cttcatgata gaaggagaat tcgacagcga ccgtgtagtg gaaggcgccg tcatcccctt
     9241 gatgacttct gaaggtcaac gcatcaatgg aagtgtagta gaagtaaagg aagacgtagt
     9301 tgtaatggac atgaatcatc cactcgcagg ttgtgatttg aactttaccg gagaagtggt
     9361 ggaaagccgt ccggctacga acgaagagct tgctgaagtt gcccgtatga tgggtggcgg
     9421 ttgcggcagc tgcggttgtg gtgactgtgg cgacggatgc ggcgaccatg aatgtggagg
     9481 cggatgctgc cactaaagaa ttaaaaatta aagaattaaa aattaaagaa tcagactaca
     9541 cagtattaag catgccgcat ggtaattctt taatttttaa ttctttaatt ttcaaattct
     9601 atattattta cttgtcatta tctccaatac caatttatcc gtttcattca ttcctttaga
     9661 accgattttt gtcagattac ggatactctg atccacatcc tcatcaataa taccttctac
     9721 ggaagtcaca caacggtttt ccatggccat gatggctgaa agcactgcgg ttgaaactcc
     9781 ggtagttact ttcaatgcac aactgggttt ggcaccatca caaatcattc cggtaagatt
     9841 ggcaatcatg ttctgcacag catatgccac ctgttcataa gttcctccca ttagccaagt
     9901 tataccgcaa ctggaacccg tagcagcaac cacacaaccg cataaggcag ataagcgtcc
     9961 caaactctgc ttgatataga ttactgttaa atggctcaac atcaaggcac gaatcaattc
    10021 ttcttccgat tttccatttt cttcggcata gaccagtacg ggaagggtag cggatatccc
    10081 ttgattgcca ctgccggaat tgctcatcac cggaatcatg gcaccggcca tacgggcatc
    10141 acatgctccc gaagtgtaag aaaggatatg agagaagaca ctgtcgccca taatccggtg
    10201 ttcgtaagtg ccacgtagga ttttacccag tccatgacca tattcacctt cgaaggaacg
    10261 ttcggcggca gtcttgttca gtcgtgccgt atcaagaata aaacgaatgt cgtctaatgg
    10321 ggttgtcatg gcgaagtcat acactttgcg taaagtcaag tccaatacat cctcctcctc
    10381 ttcgatgcaa gaagcggttt gtttgtccag caggatatcc ccgttgtgcg ttatataagt
    10441 aaagcaagta tgtccaccag caataatggc ggttgccttg tccgtatcgg cttcacagca
    10501 gacttctata taaagtttct cttctatatc gtcttttaag gatatatgga tacgcttttc
    10561 ttctatgaaa cgctttcctg cctccactgc atcaggggta ctgtctttca aaacctccaa
    10621 ttgatatacc gacttgccta ttaaagcgcc aagcgccaca gcaatcggta atccaatcat
    10681 ccccgtacca ggaataccca ctcccattgc attcttcaga atattggcac tcagcaatac
    10741 ggttatcttt tcgggacgct tattcaacac ttccacagcc tttgctacac acaatgctac
    10801 tgctataggt tctgtacaac caatggcagg gacgacctcg ttcttgacaa gggcaatgat
    10861 ttgcagtctt tccgtttcag tcatatttat tcaaatttga tgcaggcaaa gataatgtat
    10921 tttattctat aataaaacga acaaaaaaat aaaaaagagg attccaagca cagaaccctc
    10981 tttatagata aagaaaaatc ttttcttatt ttttataaga attgtcacca agacttatac
    11041 ctaaattgaa tctggtagta acattccaaa ttccttctat ttcagtcatt gagttcaagg
    11101 cagtcagcat ctgaatcata ttccacaaag gtatactctg tccccataat tcaatgttcg
    11161 tgttctttaa caacgcatct acatcaggta acatcggata gagagcaggc ataaaaatat
    11221 caaataaatc cttatccaaa tagatagaga gatcatttac cgttcttacg agctcttcct
    11281 cgttctttat ctccaattgg gtggttctat agttcaaggg gaaaccatcg attacatagc
    11341 taatcagctt ttcaatatca ctatcagaaa ttttagaaat atctaacttt ttcagcatat
    11401 tatcatcttc aagtccagcc aacaactgac ccaacaaatt cttgatgtca gctccactca
    11461 tgctcttcac catttctata atctgcaaaa cagcttccgg agtcatttga gaatcctcag
    11521 catctttcaa tgcttcggtt acaatggcag gaatattcag cacaacatag atatgctcac
    11581 ccttcacata ccaataagcc agatttgtgg gagaagtttt ccaaacaatg ccgtccgttg
    11641 aagggagctg ccccataccg gccataatca tctgatccat agtaatgttt atttcttctg
    11701 catagctggc tacaatagaa ccatcagctt tgaactctac atctttcaaa agctgtatca
    11761 tagccgcaga taggacattc gtccctactg tcgagatatt atccgctgca atccctgcat
    11821 taccaccttc tccataaggc gatacccaag tcaatcttcc cggagcataa
//
