LOCUS       c00165_gnlPro..         8646 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EDGALAIC_165.
ACCESSION   c00165_gnlPro..
VERSION     c00165_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 02:48:35
            Original ID  :: gnl|Prokka|EDGALAIC_165
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8646
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8646
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1219:5781]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1220..5781
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..8646
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..8646
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             48..1046
                     /locus_tag="ctg165_1"
                     /transl_table=11
                     /translation="MPLKLTTYYRGKDIPDLPGTNTFHSKELFQIYESTPGYTPLLIVA
                     TEEGRPVARLLAAIRKTKKWLPSSLVKQCVVYGAGEFLDTSLPASKEKEEEIFGEMLEH
                     LTQEASRTCILIEFRNLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRI
                     RQIRKGLKNGAKVVEAHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQ
                     AKIFIVKYKEKIIGGSVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRISWSWLNNLLVKFYV"
     CDS             1220..1624
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg165_2"
                     /sec_met_domain="Glyoxalase_4 (E-value: 8.5e-25, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             1655..3208
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg165_3"
                     /sec_met_domain="CT_Btheta (E-value: 2.6e-291, bitscore:
                     955.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPN
                     KPYDMYEVISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             3240..4160
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg165_4"
                     /sec_met_domain="OAD_gamma (E-value: 2.2e-15, bitscore:
                     46.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLLLNEVLIDNQNNFQD
                     DYGLHSAWIEIFNKSYGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGTLGPNQSYARISDGAADW
                     EVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSISAMSVVFCGLILLFIAFK
                     VVGKVAVNLSKRNAMKAKGIDKVEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             4185..4619
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg165_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 5.2e-22, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKTA
                     PKPVVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             4621..5781
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg165_6"
                     /sec_met_domain="OAD_beta (E-value: 8.5e-154, bitscore:
                     500.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATGGHIAMIIIGLGFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             5956..7290
                     /locus_tag="ctg165_7"
                     /transl_table=11
                     /translation="MKRIILLAFLCTTTLVMAQRINHVQEAIANYDYEAALTLIAKEKP
                     TIPLLLQKGKAQRGLGMNTEALSTYQEIIANDTANTRAYIEAAECCRSLAKYQQALKYY
                     EQALDLNPENKYVRIQYIGLLLSLQKFQDALGESSLMTEKDSSAIALHLQAQSFEGMGE
                     LLPATGCYYNIQEKYPDDYLAAAKLAALNIAGSYFNEAIEATEKYRQTDTTNIAVNRQN
                     ALAYCLNKDYPTAIQRYEYLVSQGDSSFHTCYYLGISYYAEEKYYEAHDFLEAARKHDP
                     ENVNLLYYLGRACAKTSWKKLGVEYLEKALDLTIPKDSNMVRLYIGMTDCYKMAQMPKE
                     QIESIRERYRKYDKQNHKLLYDMAFIYFYSLKDKKNTERCLEAFLKTRPKEDKEEEAKL
                     NERGELVLGTKNYYNAAANWLKDIQSKQKIEDFFLGGNVPAQKPE"
     CDS             complement(7370..8374)
                     /locus_tag="ctg165_8"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPATGRMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPEEEVETINKFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKILNVLGSDNKLAE"
ORIGIN
        1 cttttttatt gttgaatgaa gaataaaaag tgtaaatttg tatttggatg ccacttaaac
       61 taacaacata ttatcgcgga aaagacattc ctgatttacc gggaaccaat acttttcatt
      121 ccaaggagtt gtttcagatc tatgaatcga ctccgggata taccccgcta ctgatagtgg
      181 caacagaaga aggcagacct gtagcacgcc tgcttgccgc catacgcaag accaaaaagt
      241 ggcttccctc ctctcttgtc aaacaatgtg tggtatatgg tgcaggtgaa tttctggaca
      301 cttctctacc ggcaagtaaa gagaaggagg aagaaatttt cggtgaaatg ctggagcatc
      361 tcacacaaga agcatcacgc acctgcattc ttattgaatt ccgcaatctg gataattcca
      421 tgttcggtta ccgtttcttc cgaaagaacg acttttttcc ggtcaactgg ttgcgtgtcc
      481 gtaactctct gcatagtacg cagaaagcgg aagaccgttt cagcccatca cgtatccgtc
      541 agatccggaa agggctcaaa aacggagcca aagtagtaga agcccatacg gtggaagaga
      601 ttaaggaatt ctcgcggatg ctgcacaaag tttattcttc acgaatacgg agatatttcc
      661 ctgccaatga ctttttccgc cacatgaaca gcatgcttat cagaggaaaa caggcaaaaa
      721 tattcatcgt aaaatacaag gaaaagatta tcggcggctc cgtctgcatc tattccggcg
      781 aaaatgcttt tatctggttt tcaggaggaa tgcgaaagac ctatgcactg cagtcacccg
      841 gcatactggc agtatggaaa gcacttgaag atgcccatga acggggattc cgtcacatgg
      901 agttcatgga tgtaggactt cccttccgca agcatggtta tcgtgatttc gtactccgtt
      961 tcggaggcaa acaaagcagt acccgccgct ggttccgtat cagctggtca tggctgaata
     1021 atcttctggt caagttttat gtctaaatgt aatctcaaga ttacaaaacc cgtctttgtc
     1081 acccatccgg agcatttttt atgctttatt ccccaataat taaatgcaga aatatttctt
     1141 tattagacaa gaaatgtctt tctttgtgct gttttatgcc atataagcac ataattaaac
     1201 catataaaaa aatatagtta tgaagatttc acacattgag catctgggca ttgctgtaaa
     1261 aagcatcgaa gaagcccttc cttactacga aaacgtattg ggtctgaaat gttacaacat
     1321 cgaaacagta gaagatcaaa aagtaagaac cgctttttta aaggtaggtg aaacaaaaat
     1381 cgaattgttg gagccgactt gccccgaaag caccattgct aaatttattg aaaacaaagg
     1441 tgcaggtgtt catcacgtag catttgccgt agaagatggc gtagctaatg ctttggcaga
     1501 agcagaaagc aaagaaatcc gtctgattga caaggctccc cgcaaaggtg ccgaaggtct
     1561 gaacatcgct ttccttcacc cgaaatcaac actgggtgtg ctgacagaac tctgcgaaca
     1621 ctaatcataa actctaaaaa aacaacaaga actcatgagt aatcaacttg aaaaaattaa
     1681 agagcttatt gaacgccgtg ccgttgcacg catcggaggc ggcgaaaaag caattgcgaa
     1741 gcaacatgaa aaagggaaat acacagcgcg tgagcgtata gccatgctgt tggatgaagg
     1801 tagcttcgaa gaaatggaca tgttcgttga gcacagatgc acgaacttcg gcatggagaa
     1861 aaagcactat ccgggtgatg gtgtagtaac cggttgcggt actatcgaag gtcgtctcgt
     1921 atatcttttt gcacaggact ttaccgttac tgcaggttca ctgtcggaaa caatgtcact
     1981 gaagatctgt aagattatgg atcaggcaat gaagatgggt gctccttgta tcggtatcaa
     2041 tgactcgggc ggtgcacgta tccaggaagg tattaacgct ttggcaggtt acgcagaaat
     2101 cttccagcgc aatatcctcg cttcgggtgt cattccgcag atttccggta tcttcggtcc
     2161 ttgtgccggc ggtgctgttt attctccggc actgacagac ttcacactga tgatggaagg
     2221 tacttcttat atgttcctta caggtccgaa agttgtgaaa actgtaaccg gtgaagacgt
     2281 aagccaggaa aacctcggcg gagcaagcgt tcactctacc aaatcgggtg ttactcattt
     2341 cactgccaaa acagaagaag aaggtctggc attgatccgc acacttctga gctatattcc
     2401 tcaaaacaac ctcgaagaag ctccatatgt ggattgcaca gatccgatcg accgtctgga
     2461 agattcactg aacgatatta tccccgacag ccccaacaaa ccgtatgata tgtacgaggt
     2521 tatcagcgct atcgtagaca acggcgaatt cctggaaatc cagaaagact atgccaagaa
     2581 tatcattatc ggttttgccc gtttcaacgg tcagtctgta ggtattgtag ccaatcagcc
     2641 taaattcctt gccggtgtac tcgacagcaa cgcatctcgc aaaggcgcac gtttcgttcg
     2701 tttctgcgat gctttcaata tccctatcgt gtcgttggta gacgtaccgg gattccttcc
     2761 gggaacaggc caggaataca atggcgttat ccttcatggt gccaaactgc tgtatgctta
     2821 cggtgaagct actgtaccta aagtaacaat cacattgcgt aaatcttacg gtggttctca
     2881 catcgtgatg agttgtaaac aacttcgtgg tgacatgaac tatgcttggc caacagctga
     2941 aatcgctgta atgggtggtg caggtgcagt agaagtattg tacgcgcgtg aagccaaaga
     3001 ccaggaaaat ccggctcagt tccttgccga aaaagaagca gaatatacaa aactgtttgc
     3061 caacccttat aatgcagcta agtatggtta catcgatgat gtcatcgaac cccgtaacac
     3121 acgtttccgc gtgatccgtg ctttgcagca gttgcagact aagaaactgt ctaatccggc
     3181 gaagaaacat ggtaatattc cgttgtaatc caacttttca cattaaaaca agaacgatta
     3241 tgaacaaaac caaaatcgga atattccttt ctctgctgtt gctgattgga ttgacttcct
     3301 gcggagagca aaagtcgaac aataagctat tgctgaatga agtcctgata gacaatcaaa
     3361 acaactttca ggatgactac ggcttgcaca gtgcatggat tgaaatattc aacaaatcat
     3421 acggtagcgc agacttagca gcttgtttat tgaaagtaag cagccagccg ggcgatacag
     3481 taacctattt tatcccgaaa ggtgacatac ttacattagt aaagccacgc caacatgcgt
     3541 tattttgggc agacggcgaa cctaatcgtg gtaccttcca taccagcttc aaactgaacc
     3601 ctgaaacagc caattgggtc ggtctttttg attcaggcag aaagctactt gatcaagttg
     3661 tcataccagc aggaacttta ggtcccaacc agtcttatgc acgcataagc gacggagcag
     3721 cagactggga agtaaaaggc ggaagcaaag acaaatacgt aaccccgagc acgaacaaca
     3781 aaacccttga cagtaatgcc aagatggaaa agttcgaaga acatgactca gtcggtatcg
     3841 gtatgtctat ttcagccatg agcgtagtat tctgcggatt gattcttctc ttcattgcct
     3901 tcaaggtggt aggtaaagtt gctgtcaacc tgagcaaacg caatgcgatg aaggctaaag
     3961 gcatcgataa agtcgaagcg aaagagcttt cacaggctcc gggtgaagtt tatgctgcta
     4021 tttcaatggc attacacgaa atgcaggatg aggtacatga cgtagaagaa acggtgctga
     4081 ccatcactcg tgtgaaacgc agctattcac cgtggagttc gaagatttac accttgcgtg
     4141 aaaatcctaa cagaaagtaa atcattccct aaaaagataa aacgatgaaa gaatataaat
     4201 ataaaatcaa cggtaactca tacaaagtaa ccatcggaga tattgaagat aatatcgctc
     4261 atgtagaagt gaacggtacg cactacaaag tagaaatgga gaaacaaccg aaaactgctc
     4321 ccaaaccggt agtagtacgt cctatgccta actcaccggc tgctcctacc acaccggtag
     4381 taaaaccggc tgctccttct acaggcaaat caggcgttaa gtccccgcta ccaggcgtta
     4441 tccttgacat caaagtaaat gtaggtgata cagtgaaaag aggacagact atcattatat
     4501 tggaagccat gaagatggaa aacaatatca atgcagacaa agacggtaaa gtgactgcca
     4561 tcaatgtcaa caagggagat tctgttcttg aaggtaatga cctcgtaatt attgaataat
     4621 atgggagatt ttattaactt tttaggaaat aaccttgccg atttctggac ctacacggga
     4681 tttgccaacg cgacaggtgg acatattgct atgatcatta tcggtttagg ctttatttac
     4741 ttagctgtag ccaaagagtt cgagccgatg ttgttaattc ctatcggatt cggtattctg
     4801 atcggtaata tacctttcaa tatggacgcc ggactaaaag tcggtatata tgaagaaggt
     4861 tctgtattga acatattgta tcagggagta acgtccggct ggtatccacc gctcatcttc
     4921 ttaggtatcg gtgccatgac agacttctcg gcgctaatct ccaatccgaa gctgatgctg
     4981 atcggtgcgg ctgcccagtt tggtatcttc ggtgcataca tgatcgcatt ggaaatggga
     5041 tttgacccga tgcaggccgg tgctatcggt atcatcggtg gagcagatgg tccgacggct
     5101 atcttccttt cgtccaagct ggcacctaac ttaatgggag ccattgcggt atccgcctac
     5161 tcctatatgg cgttagttcc ggtgatacag ccgcctatca tgcgtctgct caccaccaaa
     5221 cacgaacgcg ttatccgtat gaaaccgcca cgtgccgttt ctcatacaga gaaagtgatt
     5281 ttcccgatta tcggtctgtt gctgacctgc ttcctagttc cttccggtct gcctctgttg
     5341 ggtatgctgt tcttcggtaa cctgttgaaa gaaagtggtg taacccgccg tctggctaac
     5401 acagccagcg gtccgctgat tgacgttatc actatcctgt taggtttgac agtaggtgct
     5461 tctactcagg cttctgagtt cctgacactc gactccatca agatcttcgc cctcggtgct
     5521 ttgtcattta ttattgctac tgcatcaggt gtgatcttcg ttaagatctt caacctcttc
     5581 ctcaagaagg gcaataagat caatccgttg atcggtaatg caggtgtatc tgccgttccc
     5641 gactctgcac gtatctcaca agttgtcggt ctggaatatg atcctaccaa ctacttgctg
     5701 atgcacgcta tgggtccgaa cgtagcaggt gtaatcggtt cggctgttgc tgccggtatc
     5761 ctgttaggat tcttaatgta gggacaaaat attaggtgcg gatattgctg ttttagatgc
     5821 aatatccgca cttatcatta tgttatcttc tcttatcatt ccgttaatct attccaaaaa
     5881 ggctacgaat aattcgtaaa tacgatattt tttagcatct tgcgtctttg ttacgacaca
     5941 ctaaaataaa tatttatgaa acggattatt ctcctcgcct tcctttgtac caccaccctg
     6001 gtgatggcgc agcgcatcaa tcatgttcag gaagcaatag caaactacga ttacgaggca
     6061 gctctcactc tcattgccaa agaaaagccg acaattcccc tactcttgca aaaaggtaaa
     6121 gcacaacggg gacttgggat gaatacagaa gcactttcca cttatcagga aatcatagcc
     6181 aatgatactg ccaatacccg tgcatatatc gaagcagccg aatgctgccg ttcattggcc
     6241 aaataccaac aggcactgaa atattatgaa caggcacttg atctgaatcc ggaaaacaaa
     6301 tatgtgcgta ttcaatacat cggactactg ctctctttac agaagtttca ggatgcttta
     6361 ggagaaagta gtctgatgac agagaaagac agttccgcca tcgccttgca tctgcaggcc
     6421 caaagtttcg aaggtatggg agagcttctc cccgccacgg ggtgctacta taatatacag
     6481 gagaaatacc ccgacgacta tcttgccgcc gccaagctcg ccgcactgaa catagccggt
     6541 tcttatttca acgaagcaat tgaagccacg gagaaatatc ggcagactga taccaccaat
     6601 atcgctgtca accgtcagaa tgcactggca tattgtctga ataaggatta tcctaccgct
     6661 atccagcgtt atgaatacct ggtgagccag ggcgacagtt cttttcatac ctgttattat
     6721 ctgggtatca gctattatgc ggaagagaaa tattacgaag cacatgactt tctggaagcc
     6781 gcccgaaaac atgatcctga aaacgtaaac ctgctttatt atctcggccg tgcctgcgcc
     6841 aagacttcat ggaagaagtt aggcgtagag tatctcgaaa aagcgcttga tctgactatt
     6901 cccaaagaca gtaatatggt acggctctat attggcatga ccgactgcta caaaatggca
     6961 cagatgccta aagagcagat tgaatcgatc agagaacgct accggaaata cgataaacaa
     7021 aatcataagc tgctctatga tatggctttc atttatttct attcgctgaa agacaagaaa
     7081 aacaccgaac gctgtctgga agcattctta aaaacacgcc cgaaagaaga taaggaagaa
     7141 gaagcgaaac taaacgaacg aggcgaactc gttttaggca ctaagaatta ttataatgct
     7201 gcagccaact ggctgaaaga cattcaaagt aagcaaaaga tagaagattt cttcttggga
     7261 ggaaatgtgc ccgctcagaa accggaataa gcagataaag gatattacgt aaaaaaggct
     7321 gcaaccgtca aacgattgca gcctttctat ataataggat aatctgtgat tattcagcca
     7381 atttgttgtc tgaacccagc acattaagga ttttgtgctt gtacagtttt tccatgttgt
     7441 cacgagccgg accaagatac ttacgtgggt cgaattcagc tggtttttca gcgaaagtct
     7501 tacggatagc agcagtcata gccagacgag agtctgagtc gatgttgatt ttgcaaacag
     7561 cagacttggc agctttacgc aattcttctt caggaatacc gatagcagct ttcagagcac
     7621 caccaaactt gttgattgtt tcaacttctt cttcaggaac tgaagatgat ccgtgaagta
     7681 cgatagggaa tcccggaagt ttttccatta cagcatccaa tacttcgaaa gccaatggag
     7741 gaggaaccat acgaccggta gccggatcga tgtggcactg ttccggagta aacttgtaag
     7801 caccgtgaga agtaccgata gagatagcca atgagtcaca acctgtacga gtagcgaaat
     7861 cgattacttc ttcagggtca gtgtatgtgt ggtggtcaga agaaacttca tcttctacac
     7921 ctgccaatac accaagttca ccttcaactg ttacgtcgaa ctgatgagcg tattcaacca
     7981 ccttcttagt caaagcaacg ttttcttcgt aaggaagatg agaaccatcg atcataactg
     8041 aagagaaacc tgaatcgatg caagatttgc aagtttcaaa agtatctccg tggtcaaggt
     8101 gaagaacgat ttcaggatgt gcgcaaccta attcttttgc gtactctaca gcaccctgag
     8161 ccatgtaacg caacaaagta gcgttagcat actgacgagc acctttagaa acctgaagaa
     8221 tcaccggaga ttttgtttct actgcagcct tgatgatagc ctgcatctgt tccatattgt
     8281 tgaagttgaa tgctgggata gcgtatccac ccttaatagc cttagcaaac atgtctcttg
     8341 tgtttaccaa tcctaagtct ttgtaattaa ccattttgtt taaagtttat tgttagtgaa
     8401 ttaaaattct acgcaaaagt aagcattatc caccgaataa cgagcatcgg aaagaaaaat
     8461 ataatagaaa aaggtttaaa tcgatcagca aatattcatc cgtaagcggg tctgacatta
     8521 gattgtaatg tccacctagc aaataaacgg ctgaaaggtt ctatcccaaa acaggaaaga
     8581 taaagagaac cccttccagc ttgcaccacc gtggatgcca tactgataac gacgggtact
     8641 attacc
//
