LOCUS       gnlProkkaILJGGLAL_548  12470 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ILJGGLAL_548.
ACCESSION   gnlProkkaILJGGLAL_548
VERSION     gnlProkkaILJGGLAL_548
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 07:26:19
            Original ID  :: gnl|Prokka|ILJGGLAL_548
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12470
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12470
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[772:1996]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      773..1996
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..12470
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12470
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(2..493)
                     /locus_tag="ctg548_1"
                     /transl_table=11
                     /translation="MSTWKGKTRGGTFGYLFFIYLIKYLGITAAYGFLSLVVLYFIPFA
                     PKATKSTWFYARHILKYSRLRSFGILLRNYYRLGQILIDKVAITNGKVKKYQFEFERYS
                     EFLQLLNSEQGVIMIGAHVGNWEIGVPFFDDYGKKINIVMYDAEHRKIKEMLEKNGQDK
                     E"
     CDS             complement(498..749)
                     /NRPS_PKS="Domain: PP-binding (8-75). E-value: 6.3e-13.
                     Score: 41.0. Matches aSDomain:
                     nrpspksdomains_ctg548_2_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg548_2"
                     /sec_met_domain="PP-binding (E-value: 1.5e-13, bitscore:
                     41.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRITLAEEFEVDIEVIQPDAPLMETLELDSLDLVDM
                     VVLVEKNFGFNVTGQDFAGIKTFQDFYDLVITRMQEAK"
     aSDomain        complement(525..725)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg548_2_PP-binding.1"
                     /evalue="6.30E-13"
                     /label="ctg548_2_PP-binding.1"
                     /locus_tag="ctg548_2"
                     /protein_end="75"
                     /protein_start="8"
                     /score="41.0"
                     /tool="antismash"
                     /translation="KIRITLAEEFEVDIEVIQPDAPLMETLELDSLDLVDMVVLVEKNF
                     GFNVTGQDFAGIKTFQDFYDLV"
     CDS             complement(773..1996)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (61-404). E-value:
                     4.2e-52. Score: 169.3. Matches aSDomain:
                     nrpspksdomains_ctg548_3_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 294.6; E-value:
                     2.1e-89)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg548_3"
                     /sec_met_domain="APE_KS1 (E-value: 2.1e-158, bitscore:
                     517.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGKNLDEVKDSLYNGKSGIGIDPVRKELGYF
                     SALTGILERPELKKLLDRRKRLCLPEQGEYAYLSTLEAFRNAGIDEAFLEANEVGILYG
                     NDSSAAPVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACA
                     SGSHAIGMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDK
                     RRDGLIPSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQM
                     AIKDARIALDRIAYINAHATSTPVGDLNEAKAIAEVFEGHRPYVTSTKSMTGHEMWMAG
                     ASEVIYSTLMMNNGFIAPNLNFEEPDEASAQLNIPAQRVDMEFDTFLSNSFGFGGTNST
                     LILRKINE"
     aSDomain        complement(785..1813)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg548_3_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="4.20E-52"
                     /label="ctg548_3_PKS_KS.1"
                     /locus_tag="ctg548_3"
                     /protein_end="404"
                     /protein_start="61"
                     /score="169.3"
                     /tool="antismash"
                     /translation="DRRKRLCLPEQGEYAYLSTLEAFRNAGIDEAFLEANEVGILYGND
                     SSAAPVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACASG
                     SHAIGMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDKRR
                     DGLIPSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQMAI
                     KDARIALDRIAYINAHATSTPVGDLNEAKAIAEVFEGHRPYVTSTKSMTGHEMWMAGAS
                     EVIYSTLMMNNGFIAPNLNFEEPDEASAQLNIPAQRVDMEFDTFLSNSFGFGGTNSTLI
                     LRK"
     CDS             complement(2022..2750)
                     /NRPS_PKS="Domain: PKS_KR (3-169). E-value: 4e-14. Score:
                     44.8. Matches aSDomain: nrpspksdomains_ctg548_4_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     215.1; E-value: 1.9e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg548_4"
                     /sec_met_domain="adh_short (E-value: 4e-35, bitscore:
                     111.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRSVSCKLAEMGYFILINYQSNDTEAGKTLQL
                     VREKGSDGELMKFDVTDPAAIADALGEWNARHPDEYIEVLVNNAGIRKDNLMLWMTGEE
                     WSKVIDISLNGFFYVTQPLLKNMLVKRYGRIINIVSLSGIQGMAGQANYSAAKGGVIAA
                     TKALAQEVAKKKVTVNAVAPGFIRTDMTEGIDENEWKKHIPAGRFGTPEEVAELVGFLA
                     SPASSYITGEVISINGGLYT"
     aSDomain        complement(2244..2741)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg548_4_PKS_KR.1"
                     /evalue="4.00E-14"
                     /label="ctg548_4_PKS_KR.1"
                     /locus_tag="ctg548_4"
                     /protein_end="169"
                     /protein_start="3"
                     /score="44.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRSVSCKLAEMGYFILINYQSNDTEAGKTLQLVRE
                     KGSDGELMKFDVTDPAAIADALGEWNARHPDEYIEVLVNNAGIRKDNLMLWMTGEEWSK
                     VIDISLNGFFYVTQPLLKNMLVKRYGRIINIVSLSGIQGMAGQANYSAAKGGVIAATKA
                     LAQ"
     CDS_motif       complement(2676..2738)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg548_4_0001"
                     /evalue="1.50E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg548_4"
                     /protein_end="25"
                     /protein_start="4"
                     /score="14.4"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRSVSCKLAEMG"
     CDS             complement(2752..4275)
                     /locus_tag="ctg548_5"
                     /transl_table=11
                     /translation="MTADKSINLDTLYKVLFENERLDLSEECIRKVEESFHFLQSFSSD
                     KIIYGINTGFGPMAQYRIEDQSLIDLQYNIIRSHSTGAGEPLPELYVKAAMIARLYTFL
                     QGKSGVHMELVSLLCEFINRGIYPFIPEHGSVGASGDLVQLAHIALTLIGEGEVFYQGR
                     LRNAADVLRENNLKPFTMRIREGLSVTNGTSVMTGIGIVNLIYARNLLHWSVAASVIMN
                     EIAASYDDLMSQALNEAKHHKGQQEIAAMMRDWVAGSQCVRKRENELYNQIHTEKIFEH
                     KVQAYYSLRCVPQVLGPVYDELENAEKVLINEINSACDNPIVDPETQNIYHGGNFHGDY
                     ISFEMDKLKIAVTKLTMLCERQINYLFHDRINGILPPFVNLGVLGLNYGLQASQFTATS
                     TTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKKVIENSYQVMAIQFMGIVQAI
                     DYLKIQEQLSPKSRRVYKEIRSFFPVFTEDTPKYKEIERMISYLKKENK"
     CDS             complement(4447..4884)
                     /locus_tag="ctg548_6"
                     /transl_table=11
                     /translation="MEEIVFHHALPIQLRFNDVDKFGHVNNTVYFSFYDLGKTEYFASV
                     CPGVDWEKIGIVVVHIEANFVKQIFASDHIAVQTAVSEIGTKSFHLIQRVIDTETQEVK
                     CICKSIMVTFDLEKHESMPLTEDWIEAICKFEGKDVRKKKN"
     CDS             4996..5526
                     /locus_tag="ctg548_7"
                     /transl_table=11
                     /translation="MNEGGVILYPTDTVWGIGCDATNEEAVHRVYEIKKRADSKAMLVL
                     VDSPVKVDFYVQDVPDVAWDLIEVADKPLTIIYSGARNLAPNLLAEDGSVGIRVTNEEF
                     SRRLCQQFRKAIVSTSANISGQPGAANFTEISEEVKSAVDYIVGFRQDDMSRPKPSSII
                     KLDKGGVIKIIRE"
     CDS             5527..7323
                     /locus_tag="ctg548_8"
                     /transl_table=11
                     /translation="MKREERQSLLQRCIKWREANIKEKQFILILSFLVGIFTAIAALFL
                     KFLIHQIQNFLTNNFNATSANYLYLVYPVIGIFLAGWFVRNIVKDDISHGVTKILYAIS
                     RRQGRIKRHNIWSSTIASAITIGFGGSVGAEAPIVLTGSAIGSNLGSVFKMEHRTLMLL
                     VGCGAAGAIAGIFKAPIAGLVFTLEVLMIDLTMSSLLPLLISAVTAATVSYITTGTEAM
                     FKFNLDQAFELERIPYVILLGIFCGLISLYFTRAMNSIEGVFGKLKNPYQKLAFGGVML
                     SVLIFLFPPLYGEGYDTIELLLNGTSAAEWDTVMNNSMFYGYGNLLQVYLMLIILLKVF
                     ASSATNGGGGCGGIFAPSLYLGCIAGFVFSHFSNDFAFSAYLPEKNFALMGMAGVMSGV
                     MHAPLTGVFLIAELTGGYDLFLPLMIVSVSSYLTIIAFEPHSIYSMRLAKRGQLLTHHK
                     DKAVLTLMKMENVVEKDFVAVHPEMDLGELVKAIAASHRNMFPVTDKKTGELLGIVLLD
                     DIRNIMFRQELYHRFTVNKLMTSAPAKIFDTDGMEQVMQTFDDTKAWNLPVVDEEGRYQ
                     GFVSKSKIFNSYRQVLVHFSED"
     CDS             7356..8294
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1228:methionyl-tRNA formyltransferase (Score: 204;
                     E-value: 4.3e-62)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg548_9"
                     /transl_table=11
                     /translation="MGTPDFAVEALRQLVEGGYNVVGVITMPDKPAGRGHKIQYSPVKQ
                     YALEQNLPLLQPEKLKDEAFVQALREWKADLQIVVAFRMLPEVVWNMPRLGTFNLHASL
                     LPQYRGAAPINWAVINGDTETGITTFFLQHEIDTGKVIQQVRVPIADTDNVEVVHDKLM
                     ILGGKLVLETVDAILNDTVKPIAQEDMAVVGELRPAPKIFKETCRIDWNSPVKKVYDFI
                     RGLSPYPAAWSELVSPEGEAVVMKIFESEKIYEAHQLPVGTVVTDGKKYIKVAVPDGFV
                     SVLSLQLPGKKRLKTDELLRGFRLSDGYKMN"
     CDS             8347..8997
                     /locus_tag="ctg548_10"
                     /transl_table=11
                     /translation="MKPIISPSILSADFGYLARDIEMINRSEAEWVHIDIMDGVFVPNI
                     SFGFPVLKYVAKLTDKPLDVHLMIVNPEKFIPEVKALGAHTMNVHYEACTHLHRVIQQI
                     KEAGMQPAVTINPATPVALLQDIIQDVYMVLIMSVNPGFGGQKFIEHSVEKVRELRALI
                     ERTGSKALIEVDGGVNLETGARLVEAGADVLVAGNAVFGAPDPEEMIRQLHKL"
     CDS             9006..11108
                     /locus_tag="ctg548_11"
                     /transl_table=11
                     /translation="MNTASLHQYPYIRLIIPWIAGVFCGDWFFDQSTELFWSILNFGLF
                     AGLCIALYFLKRRSLRWCFGISVFALCFAGGWLGITCQLKQTVYDFPEKEAVYRVRLTD
                     TPETKERTLLCRVLLKELRDSSGVCPIGRKAILYLQKDSLFTLLKLGDKQLKIGDELLV
                     SARIAPPANGGNFDEFDYARYLMRHGISGTGYVASGKWALWSPSIRYTAMFCQEKVINL
                     YRKLGFEGDELAVLSALTVGEKTDLSDSIRESYSVSGASHVLALSGLHIGLLYALLFLL
                     LKPLARKWQAGRYFRSVLLLVLLWSFAFFTGLSPSVVRSVSMFSVLAIAELFGRQSLTL
                     NTLAATAWVMLFVNPAWLFDVGFQLSFLAVLSILMIQKPVYQLLPVKSRIGKYVWGLMS
                     VSIAAQIGTAPLVMLYFSRFSTHFLLTNLVVIPLVTVTLYAAVLMLLLTPLPAVQFVMA
                     GAVRFLLKVLNDFVRWVEQLPYASLDGIWLYRLEVLGIYIFLLLFLYYLKTRRFRNLVV
                     CFSCLLCLGIYHTVMRWYDRPCPSLVFYNVRGCPAIHCIAEDGTSWLNYADTLSDKRRL
                     QAVAANYWRRHQLLPPIEVTADCQNVDFCRHQQIVFYHGCRICMVTDNRWRNKYAASPL
                     FINYMYLCKGYNGRLEELTGLFSPSCILLDASLSDDRKQFFREECKRLHLHFITLSEEG
                     SVRFLL"
     CDS             11154..12191
                     /locus_tag="ctg548_12"
                     /transl_table=11
                     /translation="MLTKVIEQAKIDHFTKWFERADKIVIVSHVSPDGDAIGSSLGLYH
                     FLDSQEKTVNVIVPNAFPDFLRWMPGSKDILLYDRYKDFADKLIAEADVICCLDFNALK
                     RIDEMADAVAASPARKVMIDHHLYPEEFCKITMSYPKISSTSELIFRLICRMGYFSDIS
                     KEGAECIYTGMMTDTGGFTYNSNNREIYFIISELLSKGIDKDDIYRKVYNTYSESRLRL
                     MGYVLSNMVVYSDYNAALISLTKEEQSKFDYIKGDSEGFVNIPLTIKNVCFSCFLREDT
                     EKPMIKISLRSVGTFPCNQLAAEFFNGGGHLNASGGEFFGTIEEAKAVFEQALEKYKPL
                     LTAKS"
     CDS             12310..12468
                     /locus_tag="ctg548_13"
                     /transl_table=11
                     /translation="MKKLVFLFLSLLAAGGIFQACDDSKTYAEMLEDEKNAVNKFIKDK
                     GIRIISQD"
ORIGIN
        1 actccttgtc ctgtccgttt ttctccagca tttctttgat tttgcgatgc tcggcgtcgt
       61 acatcacaat gttgatcttc tttccgtaat catcgaagaa aggaacgccg atttcccagt
      121 ttcccacgtg ggcaccaatc atgatcactc cttgttcgct gttcagtaat tgcagaaatt
      181 cggaatatct ttcgaattcg aactggtatt tctttacttt cccgttggtg atggctactt
      241 tatctatcaa aatttgtccc aatcggtaat aattgcgaag cagtataccg aaagagcgca
      301 atcggctgta tttaaggata tggcgggcat aaaaccacgt gcttttcgtc gctttcggtg
      361 cgaaaggaat gaagtagagg actaccagac tcagaaagcc ataggcggca gtgatgccca
      421 aatacttaat cagataaatg aagaataagt atccgaacgt tcctccccgg gttttgcctt
      481 tccacgtcga catatactta ctttgcttct tgcatacggg tgatgacaag gtcgtagaag
      541 tcttggaagg tcttgatacc tgcaaagtct tgtcccgtca cattaaatcc gaagttcttt
      601 tctaccaata ctaccatatc aaccaaatcc aggctgtcca gttcgagcgt ctccatcagc
      661 ggggcatccg gttggatgac ctcgatgtct acttcaaact cttctgccaa ggttattctt
      721 attttctcga taatttcttc gtttgtcata tatctatagt tctattaatg gattattcat
      781 tgattttacg caggataagc gtggagttgg ttcctccgaa tccgaatgaa ttggaaagga
      841 aggtgtcaaa ttccatatct acccgttgtg cagggatgtt caactgtgcc gaagcttcgt
      901 ccggttcttc gaagttgagg ttaggagcaa tgaatccgtt gttcatcatc aaggtggagt
      961 agatcacttc actggcaccc gccatccaca tttcgtgtcc ggtcatcgat ttggtcgaag
     1021 tgacatacgg acggtgtcct tcgaatactt cggcgatcgc tttggcttcg ttcaggtcgc
     1081 ctaccggtgt cgaagtggcg tgcgcattga tataagcaat ccggtcgagg gcgattctcg
     1141 catcctttat ggccatctga agcgaacgtt tcggaccatc tacgttcggt acggagatgt
     1201 ggtcgccatt ggatgaaaaa ccatagccga tgacctccgc caggatgggt gcacctcttt
     1261 ttacggccga ttcatagctt tcgagtacca gactggcggc tcctccactg gggatgaggc
     1321 cgtcgcgtcg tttgtcgaaa ggttttgagg ctttttctgg ctccgcttcc tgcgtagaga
     1381 atgcgctcag tccgtcgaaa ctgcctacgg catacggatt gacttcctgt gcaccaccgc
     1441 ataagatgca atcctgtagt cccgatttga taagcagata acccatgccg atagcgtgcg
     1501 aaccgctggc gcaggcacct gcgatagtga agttgacccc tctcagtttg aagatgacag
     1561 acaggttcat ggtcaccgtc gaattcattg actggaaaat ggaaccggaa cctaccagag
     1621 ccgtgttctt cttttcacgg atgatgtcta ccgcattgat gacgggagcg gcactgctgt
     1681 cgttaccgta taagataccc acttcgttgg cttcgagaaa agcctcgtcg atgccagcgt
     1741 tgcggaaagc ctccagagtg gagagataag catattcacc ctgctccggc aggcaaagac
     1801 gtttgcggcg atccaacagc tttttcagtt cgggacgttc cagtatgcct gtcagtgccg
     1861 aaaaataacc gagttctttt cgtaccggat cgatgccgat gcccgatttt ccgttatata
     1921 gtgagtcttt tacttcatcc agattcttgc cgatgcaaga ataaatcccc attcccgtga
     1981 taaccactct tttcatttga tgtctgttct atcttttgtt tttaggtata tagtcctccg
     2041 ttgatggaaa tcacttctcc cgtgatgtaa gaggaggcag gggaggccag gaagccgacc
     2101 agttcggcca cttcttccgg agtcccgaaa cgtcccgcgg gaatatgttt cttccattcg
     2161 ttttcgtcga tcccttccgt catgtctgtg cggataaatc ccggagcaac ggcattgaca
     2221 gtcactttct ttttggctac ctcctgtgcc agtgccttcg ttgcggctat tacgccacct
     2281 ttggcggcgg aatagttggc ttgtcctgcc attccctgta tgcccgacaa agacacgatg
     2341 ttgataatac gtccgtatcg cttgaccagc atatttttca gcaatggctg tgtcacgtag
     2401 aagaaaccgt tcagactgat atcgatcact ttgctccatt cttcgcctgt catccagagc
     2461 atcagattat ctttgcggat accggcattg ttcacaagca cttcgatata ctcgtcgggg
     2521 tgccgggcat tccattctcc caaagcatcg gcgatggcgg cagggtcggt tacatcgaat
     2581 ttcattaact caccgtcact ccctttttcc cgcaccagtt gcagtgtctt tcccgcttcc
     2641 gtatcgttac tctgatagtt gataagtatg aagtagccca tctccgccaa cttgcagctg
     2701 acggaacgac cgataccacg gcttcctccg gttactaatg catatttcat attatttatt
     2761 ttcttttttg agatagctta tcattctttc tatctctttg tatttgggtg tatcctccgt
     2821 gaatacaggg aagaaactgc gtatttcctt atatacccga cggcttttgg gactcagctg
     2881 ttcctgaatc ttcagatagt cgatggcctg cacaatgccc ataaactgga tagccatcac
     2941 ctgatacgaa ttctctatga cttttttggc cagtaatgcc gagttcgttc ccatgctgac
     3001 gatgtcttga ttgtcattgt tgttggggat gctgtgtaca tacatcggat tcgataatgt
     3061 ctgacattcg gcagtggtag aggtggcggt gaattgcgaa gcctgcaaac cgtagttcag
     3121 ccccagtact cccagattga cgaatggagg cagaataccg ttaatacggt cgtggaacag
     3181 atagttgatc tgcctttcgc aaagcatggt cagcttggtg acggcgattt ttagtttgtc
     3241 catctcgaag gagatgtaat cgccgtgaaa gttaccgcca tgataaatat tctgcgtttc
     3301 cggatctaca atcggattgt cgcaggcgga gttgatctcg ttgatcaata ccttctctgc
     3361 attttccagt tcgtcataaa ccggtccgag cacttgcgga acgcagcgca gtgagtaata
     3421 agcctgtact ttatgctcga agattttttc cgtatgtatc tggttgtata attcgttttc
     3481 tcttttgcgt acacattggc tgcctgccac ccagtctctc atcatggcgg ctatttcctg
     3541 ctgccctttg tgatgcttcg cttcgttcag cgcctgcgac atgaggtcgt cataagaagc
     3601 tgcgatttca ttcattatca ctgaggctgc taccgaccag tgaagcaggt tgcgggcata
     3661 tatcagatta acgataccga tgcctgtcat taccgaagtc ccgttggtta cggacagtcc
     3721 ctcgcggata cgcattgtaa agggtttcag attattctcg cggagaacgt cggcagcatt
     3781 gcgtaaccgg ccttggtaga acacttctcc ttcgcctatc aatgtcaggg cgatgtgtgc
     3841 cagttgcacg aggtcaccgc tggcacccac gcttccgtgt tcgggtatga acgggtaaat
     3901 gccacgattg atgaattcgc aaagaaggga taccagctcc atgtgtaccc ccgactttcc
     3961 ttgcaggaag gtatacaggc gtgcgatcat ggctgctttt acataaagtt cgggaagcgg
     4021 ttcgccggca cctgtagagt ggctccggat gatgttgtat tgaaggtcga tcagtgactg
     4081 gtcttcgatt ctgtattgag ccatcggacc gaatccggta ttgatgccgt agataatctt
     4141 gtcgctggag aaagattgca ggaaatggaa actttcctcc acctttcgga tacattcttc
     4201 ggaaaggtct agtctttcat tttcaaacaa tactttgtag agggtatcca aatttatact
     4261 tttgtcagct gtcattttac gctatagata tttcgtacct tatattatta aggtgcaaaa
     4321 ataggcaatt tctattatat agcggacatg attcagtata aaacttttct tatcgctcag
     4381 gttttggctc tccgaagtca ggcagcgatg aggaatggtc ccgacaccgg ggaaggctta
     4441 tttctttcag tttttcttct tgcgtacgtc cttcccttcg aatttgcaga ttgcctctat
     4501 ccagtcttcg gttagcggca tcgactcatg tttttccagg tcgaaagtta ccatgatcga
     4561 tttgcagata catttcacct cttgggtttc cgtgtcgatc acccgttgaa tgagatgaaa
     4621 gcttttggtt ccaatttcag aaacggcggt ttgtacggca atatgatcgg atgcgaaaat
     4681 ctgctttaca aaattggctt cgatatgaac gaccactata ccgatctttt cccagtccac
     4741 tcccggacat acggaggcga aatattcagt cttccctaag tcatagaaag aaaagtagac
     4801 agtgttgttg acgtgaccga atttatctac gtcgttgaag cgcaactgga taggcagtgc
     4861 atgatgaaat acgatttctt ccattgtttt cccttaatct tttttatttc gacgcaaaag
     4921 tactactttt gcgtgttatt ctcaacagaa atagttcaag aaatgataga agatattaaa
     4981 aaagcctgtc aggtgatgaa tgaaggaggt gtcatccttt atcctaccga tactgtatgg
     5041 ggcataggct gcgacgctac taacgaagag gctgtacacc gggtgtatga gataaaaaaa
     5101 cgtgccgata gcaaggctat gctggtactg gtagactctc ctgtgaaggt ggatttttat
     5161 gtacaggatg tccccgatgt ggcatgggac ctgatagaag tagccgataa accattgact
     5221 attatttatt ccggtgcacg gaatttggcc ccgaacctgc tggcggaaga tggcagcgtg
     5281 ggtatccggg tgaccaatga agaattctcc agacgacttt gtcagcaatt ccgtaaagcc
     5341 attgtttcca cttccgccaa tatcagcgga cagccgggag cggccaactt tactgagatc
     5401 agcgaagaag tcaagtcggc agtggactat atagtcggct tccgccagga tgatatgagc
     5461 cgtcccaagc cctcaagtat tataaagtta gataaaggcg gagtgatcaa gataattcgt
     5521 gaatagatga aaagagagga gagacagagt ttactacagc gttgcatcaa atggcgggaa
     5581 gctaatatta aggaaaagca gtttatcctg atattgagct ttctggtcgg gatcttcact
     5641 gcgattgccg ctttattttt gaagttcctt attcatcaga tacagaattt tctgacaaac
     5701 aactttaatg cgacatcggc caactatttg tatttggtat atccggtgat cggtattttc
     5761 ctggcgggat ggtttgtgcg taatatcgtg aaggatgaca tcagtcatgg tgttaccaag
     5821 atcctgtatg cgatttcgcg tcgtcaggga cgtatcaaac gacataatat ctggtcgtct
     5881 acaattgcca gtgccatcac gatcggcttc ggtggatcgg ttggagcgga ggcaccgatt
     5941 gtgctgacgg gttcggccat cggctccaat ctgggaagtg ttttcaagat ggaacaccgc
     6001 acgctgatgc tgctcgtcgg ctgtggcgcg gcaggggcga ttgcgggaat ctttaaggcc
     6061 ccgattgccg gactggtatt tacgctggaa gtgctgatga tcgaccttac gatgtcttct
     6121 ctgcttcctt tgctgatttc cgccgtgact gcggcaactg tttcctatat cacaaccgga
     6181 acggaggcta tgttcaagtt caacctcgac caggctttcg aactggaacg tatcccttac
     6241 gtgatcttgc tgggaatctt ctgcggactg atttctctct acttcacacg ggcgatgaac
     6301 tccatagaag gggtattcgg aaaactcaag aacccttatc agaaacttgc ttttggcggt
     6361 gtgatgctga gtgtgctgat tttccttttt cctccgctct acggtgaagg ctatgataca
     6421 atcgaacttc tgctgaacgg aacttcggca gcggaatggg acacggttat gaacaactct
     6481 atgttctacg gctatggtaa tctgttgcag gtttatctga tgctgattat cttgctgaaa
     6541 gtgtttgctt ccagtgcgac gaacggtggc ggcgggtgtg gtggtatttt cgctccttcg
     6601 ctttatctgg ggtgtattgc cggattcgta ttttctcatt tcagcaatga ctttgccttt
     6661 tccgcctatc tgcccgaaaa gaatttcgcc ttgatgggaa tggcgggtgt tatgagtggg
     6721 gttatgcacg ctccgttgac aggagtgttc ctgatagccg agctgaccgg aggttacgat
     6781 ttgttcctgc cgttgatgat tgtgtctgtc agttcttatt taacgattat agctttcgag
     6841 cctcatagta tttactccat gcgtcttgcc aagcgcggtc aactcctcac acatcataag
     6901 gataaggcag tgctgacctt gatgaagatg gagaatgtgg tggagaaaga ttttgtagcc
     6961 gtgcatccgg aaatggactt gggagagttg gtaaaagcca ttgccgcttc ccaccgtaat
     7021 atgtttccgg tgacggataa aaagaccggc gaattgttgg gaattgtcct gctcgacgat
     7081 atccgcaaca tcatgttccg gcaagaactt tatcaccgtt ttactgttaa taaattaatg
     7141 acatctgctc ctgccaagat attcgatacg gatggaatgg aacaagtgat gcagacgttt
     7201 gatgatacca aagcatggaa tctgccggta gtggacgaag aaggacgata tcagggattt
     7261 gtctccaaat caaagatatt taactcatac cgccaagtac tggtacattt ttctgaagat
     7321 tgattatgaa gaaagaagat ttaaggatag tttatatggg tactcccgat tttgcggtgg
     7381 aggccctgcg gcagttggta gagggtggtt ataacgtggt aggcgtgata acgatgcccg
     7441 ataaaccggc cggacgcgga cacaaaattc aatattctcc tgtcaagcaa tatgcactcg
     7501 aacagaactt gccgttgctg caaccggaga aactgaagga tgaggctttt gtgcaggcac
     7561 ttcgtgagtg gaaagctgat cttcagattg tggttgcttt tcgtatgttg ccggaggtgg
     7621 tctggaatat gccgcggttg ggtactttca acctgcacgc ttcgttgctt cctcagtatc
     7681 ggggtgctgc tcctatcaat tgggcggtta tcaacggcga tacggagact ggtatcacta
     7741 ccttcttcct gcaacacgag attgataccg gaaaagtgat tcagcaagta cgtgtcccca
     7801 ttgccgacac ggataatgtg gaagtggtgc acgataaact gatgatcctc ggtggtaagc
     7861 tggtgctcga aaccgtggat gcgatcttga atgatacggt gaaaccaatt gctcaggaag
     7921 atatggcagt ggtgggcgaa ctacgtcccg ctccgaagat atttaaggag acttgccgga
     7981 ttgactggaa ttctccggtg aaaaaggtgt atgatttcat tcgtggtctg tcgccttatc
     8041 ctgctgcatg gagtgagttg gtcagtccgg aaggagaagc ggtggtgatg aagatttttg
     8101 agagcgagaa gatttatgag gcacatcagt tgcctgtcgg aacagttgtg acggatggca
     8161 agaaatatat aaaggtggct gtgcccgatg gatttgtttc tgtcctctct ttgcagcttc
     8221 ccggcaagaa acgtctgaag accgatgaat tacttcgtgg attccgcttg tcggatggat
     8281 ataaaatgaa ttgatagaat gaactgacca cggtcaagct aacttagaac ttaaaacaat
     8341 agaatgatga aaccgattat ttctccttcc atcctttctg ccgactttgg ttatctggcg
     8401 agagatattg aaatgataaa ccgcagcgaa gcggagtggg tacatattga tataatggat
     8461 ggagtatttg ttcctaatat ttcattcggc ttcccggtgc tgaagtatgt agcaaagttg
     8521 acggacaaac cgttggatgt acatctgatg atagtcaatc cggagaagtt tatccctgaa
     8581 gtgaaagcgt tgggcgcaca tacgatgaat gttcactatg aggcttgtac gcatcttcat
     8641 cgggtgattc agcaaatcaa agaagctgga atgcagccgg cagtgacaat caatccggca
     8701 actcctgttg ctttattgca ggatatcatt caggatgtgt atatggtact tatcatgagt
     8761 gtgaatccgg gttttggcgg tcagaagttc attgagcatt ctgtagagaa agtccgtgaa
     8821 ttgcgtgctt taatagaacg gaccggttca aaagcattga ttgaagtgga tggaggtgtg
     8881 aatttggaaa cgggcgcccg actggtggaa gctggagcgg atgtgctggt agccggcaat
     8941 gctgtcttcg gagcaccgga cccggaagag atgatccgcc agttacacaa gttgtaacgg
     9001 acacattgaa tactgcctct ttacatcagt atccttatat acgcctgatt atcccgtgga
     9061 tagcaggcgt tttttgtgga gattggttct ttgatcaatc gacggaactg ttttggagta
     9121 ttctgaactt tggtctcttt gccggactgt gcattgccct ctattttctg aaacggcgtt
     9181 cacttcggtg gtgttttgga atatctgtct ttgcactttg tttcgcaggc gggtggctag
     9241 gcattacttg tcaattaaaa caaacggtat atgactttcc ggagaaggaa gcggtttatc
     9301 gggtacgact aacggatact ccggagacta aagaacggac gttgctctgt agggtattgc
     9361 ttaaagagct gcgagattcg tcaggggtat gtccgatagg gcgaaaggct attctttatt
     9421 tgcagaaaga ttcattgttt actttattga aactggggga taaacaatta aagataggag
     9481 atgaactgct ggtatctgcc cgcattgctc cacccgctaa cggaggaaac tttgatgagt
     9541 ttgactatgc ccgctatttg atgcgtcatg gcattagtgg aacggggtac gtagcatccg
     9601 ggaaatgggc gttatggtca ccatctatca ggtatactgc gatgttttgt caggaaaagg
     9661 tgataaacct ttatcggaag ctgggatttg aaggagatga actggctgtg ctttcagcgt
     9721 tgaccgtggg tgagaagacc gatttaagtg actctatccg tgaaagttat tcagtatccg
     9781 gtgccagtca tgtcttggct ctatccggcc tgcatatagg gcttttgtat gctttgcttt
     9841 tcctcctttt gaaacctcta gcaaggaagt ggcaggcagg gcgatatttc cgttccgttc
     9901 tgctccttgt tttattatgg tcttttgcct tttttaccgg tctgtcgccg tctgtcgtcc
     9961 gttcggtaag tatgttctcg gttttggcaa tagcagaact gttcggacgc caatcattga
    10021 ctctgaatac actggctgct accgcatggg taatgctgtt tgtcaacccg gcttggttgt
    10081 tcgatgttgg ttttcaatta tcttttctag ctgtactttc tattttgatg attcagaaac
    10141 cggtctatca gttgttgcct gtgaagagca ggataggaaa atatgtttgg ggattgatga
    10201 gtgtatcgat agctgcgcaa ataggaactg ctccgcttgt aatgctgtat ttctcccgtt
    10261 tctccactca ttttctgctg actaatttag tagtcatacc tttggtgact gtaactttgt
    10321 atgctgccgt tcttatgctt cttctgactc cactgcctgc cgttcagttt gttatggcgg
    10381 gagcagtcag attcctgttg aaagtgctga atgattttgt ccggtgggtt gagcaacttc
    10441 cttatgcttc cttggatggt atctggcttt atcgtctgga ggtgttgggc atctacattt
    10501 tcttgttgct ttttctttat tatttgaaga cccgaaggtt caggaatctt gttgtttgct
    10561 tttcctgcct gttgtgtctg ggcatttatc acacggtcat gcgctggtat gaccgtcctt
    10621 gtccgagcct tgtattttac aatgtccgtg gttgtccggc gattcattgt attgctgagg
    10681 atgggacttc ttggctgaac tatgccgata ccctttctga taagcgccgt ttgcaggctg
    10741 tagcggctaa ttattggaga cgtcatcaac ttctgcctcc aatagaagta acggctgatt
    10801 gtcagaacgt tgacttctgt cgtcatcagc agattgtatt ttatcatggc tgccgtattt
    10861 gtatggtgac cgacaatcga tggcggaaca aatatgccgc ttcaccgtta tttattaatt
    10921 atatgtactt atgcaaaggc tataacggtc gtctggaaga acttaccgga ctcttttctc
    10981 catcttgtat cctgttggat gcttcccttt ccgatgatcg caaacagttc ttccgggagg
    11041 aatgtaagag actgcatctg cattttatca ctctgtctga agaaggttct gtgcggtttt
    11101 tgctctaagt acgaagaatt atcgtacatt tgcaactcga aaaagaatat ggtatgttga
    11161 ctaaagtaat agaacaggca aaaatcgacc actttaccaa gtggtttgag cgcgctgaca
    11221 aaatagtaat cgtttctcat gtgtcgcccg acggcgatgc tatcggctct tcactggggc
    11281 tttatcactt cctggattca caggagaaga cagtaaatgt aattgttcct aacgctttcc
    11341 ccgatttcct ccgctggatg ccgggcagca aggatatcct tttgtatgac cgctataagg
    11401 actttgcgga caaattgatt gccgaagctg atgtgatttg ctgtttggac tttaatgcct
    11461 taaagcgtat tgatgagatg gcggatgccg tggcagcttc tccggcacgc aaagtgatga
    11521 tcgaccatca tctttatccc gaagaattct gtaagattac catgtcttat cctaagatat
    11581 cttccacttc agaattgata tttcgtctga tttgccgtat ggggtacttt agtgatatct
    11641 caaaggaagg agcagaatgt atctataccg gtatgatgac ggatacaggt ggctttacct
    11701 acaattccaa caatcgcgag atttatttta tcatcagcga actcctttcc aaagggattg
    11761 ataaagatga tatctaccgt aaagtataca atacatattc agagagccgc ctgcgtctga
    11821 tggggtatgt gttgtcaaat atggtggttt actcagatta caatgccgca ttgatatcgc
    11881 tgacaaagga agaacaaagt aagtttgact atataaaagg tgacagcgaa gggtttgtga
    11941 atattcccct taccattaag aacgtatgtt tctcctgttt cttgcgggaa gatacggaaa
    12001 agccgatgat taagatttcg ctccgttcgg tcggtacttt cccatgcaat cagcttgcag
    12061 ccgaattctt taacggaggc ggtcatctga atgcttcggg cggtgaattt ttcggaacga
    12121 tagaggaggc gaaagccgtt ttcgaacagg cactggagaa atataaacct ttgttgacag
    12181 ccaaaagcta agaatggaag gttaaaagta gacagagaaa ggttaaaagt taccaacttt
    12241 caactttccc ctttcatctt tcaatgaatt tgagatacat ttgtgcagaa tatagctaaa
    12301 taacagataa tgaagaaact tgtattttta tttctctctt tgttggcagc cggaggtata
    12361 ttccaggcgt gcgacgattc aaagacttat gctgaaatgt tggaggacga aaagaatgcg
    12421 gtgaataaat tcatcaaaga taaaggaatc cggatcattt cacaggacga
//
