LOCUS       gnlProkkaFACJAAOP_299  13526 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FACJAAOP_299.
ACCESSION   gnlProkkaFACJAAOP_299
VERSION     gnlProkkaFACJAAOP_299
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 03:10:00
            Original ID  :: gnl|Prokka|FACJAAOP_299
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13526
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13526
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3295:3526]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3296..3526
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13526
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13526
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             304..1815
                     /locus_tag="ctg299_1"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCHTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYST
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWQLVSE"
     CDS             1856..2956
                     /locus_tag="ctg299_2"
                     /transl_table=11
                     /translation="MFSKPVKKEPNMKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGV
                     VYSLPKTQIELEIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVP
                     NSETTYFVKLKDKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREF
                     LTEEILMASSTAKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEE
                     AMTQMFSGTCNKEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDL
                     KSVKMPQEDGKKKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLF
                     NKNSTIKVYFDPNTGGLLKVDREEGK"
     CDS             complement(3296..3526)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg299_3"
                     /sec_met_domain="PqqD_RRE (E-value: 2e-11, bitscore: 34.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.2e-17, bitscore: 54.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRFLVPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADH
                     FQYEEGYESRVSAYLSQMQKDGFIKLVIPVV"
     CDS             complement(3744..5132)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg299_4"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(5381..5587)
                     /locus_tag="ctg299_5"
                     /transl_table=11
                     /translation="MSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAPQTEA
                     PATNAPATETPAPATETPAPAAE"
     CDS             complement(5783..6556)
                     /locus_tag="ctg299_6"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(6562..7089)
                     /locus_tag="ctg299_7"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7076..8317)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg299_8"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(8327..9421)
                     /locus_tag="ctg299_9"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPIVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(9426..10250)
                     /locus_tag="ctg299_10"
                     /transl_table=11
                     /translation="MYTSPKDYDSTLKLIRNIIIVDIQDIYTKASFKYAKDVYANPQMI
                     LTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFISQKVDSLFGCDIW
                     VDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYFVHKRDSVMKANIP
                     GFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYVSHTRLDEKNQRII
                     TAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKEAEQTNK"
     CDS             complement(10485..11519)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg299_11"
                     /sec_met_domain="PF04055 (E-value: 3e-18, bitscore: 57.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
ORIGIN
        1 tttctaatat gccgatatcc ctttatccat cggcctttca atgagcttta ctagcacgga
       61 atttgattaa gaaccaaatc tttttcagga gaaataaaag taagttcata atggtgctgc
      121 attgaattat tttttggcgg agttattcta acacttaata gttcaaaagc agatatttct
      181 ctgacccaaa gatagaacta atgatgaatt aaaagttgca attatggttt tcttcccaca
      241 acaaacggga aaagtcagaa gaatcatgta catttgtaat ccgaaaacta aaagaacatc
      301 gcaatgaaaa tatttccaag cagcagtatc aagaaattgg acgcttatac cattgagaac
      361 gaacctattg catcaatcga tctgatggaa cgtgcagcaa ccgtattaac aaaagccatc
      421 acagacagat ggaatacgga aacgccggtc actatctttg ccggaccggg gaataatggc
      481 ggagacgctc tcgccgtagc ccgcatgatg gctgaaaaag gatataaaat cgaggtattt
      541 ctcttcaaca cgaaaggaga actttcaccc gactgccaaa ccaataaaga actggtagaa
      601 atgatggaag aagtaaaatt ccacgaaatc agtacccaat tcgtacctcc cgtcctgacg
      661 cccgaccatc tggtaatcga cggattattc ggttcaggcc tgaacaaacc gttaagcggc
      721 ggattcgctg ccgtagtgaa atacatcaat tcctcccctg ctatggtagt agccatcgac
      781 attccttccg gactgatggg agaagaaaac acattcaacg taaaagctaa tattatccgt
      841 gccgacgtaa ctttcagtct gcaactgccg aagctcgcct ttcttttcgc agagaacacg
      901 gaatttgtcg gagaatggga agtgctggac atccaattaa gcgaagacgg tattgaagag
      961 atggaaacga actacgaaat gttggaaata gagcaaatcc gttcactcat caagccacgc
     1021 aaacagtttg cccacaaggg gaacttcggc catgcactat tgattgccgg ttcaaaagga
     1081 atggcaggag cctctgttct cgctgcccgc gcctgcctcc gttcgggagt agggttgctg
     1141 actgtccatg cgccaatgtg caacaacgac atcttgcaga cctccatacc cgaagcaatc
     1201 gtagaaaccg acatcaacga aacctgtttt gccgtaccta ccgacacgga cgactatcaa
     1261 gcagtcggca tcggcccagg gctgggacga aacgaggaaa cggaagctgc tttattggag
     1321 caactggaac attgccatac tcctgttgtg gtggatgccg acgcacttaa tatcctcgcc
     1381 aaccaccgtc atgcacttac ccacctgccg aagggttcca tcctcacccc gcatccgaaa
     1441 gaactggaac gtctgaccgg caaatgccag gactcttacg aacgtctgat gaaggcttgc
     1501 gaattggctc gtgccgccca tgttcacatt attttaaaag gagcctactc cgccattatc
     1561 accccagaag gtaaatgttt cttcaaccca accggaaatc cgggaatggc aaccggaggt
     1621 agcggtgacg tactgaccgg agtaatcctg gcactgcttg cccaaggtta ctcaaccgaa
     1681 gaagccgcta aaatcggcac ttacattcac ggattggcgg gcgatgtcgc tcaaaagaag
     1741 caaggaatga tcggaatgat cgcaagcgat attatcacct gtctgccgac agcatggcaa
     1801 cttgtaagcg aataaaagtt aagaacttac ccttttttca ataacttcat taactttgtt
     1861 ttcaaaacca gttaaaaaag aaccgaatat gaaaaagttg attatagcag caggactact
     1921 aatgacaacg tccgcctatg cacaaaccga agtactgaca ggggttaccc gaggaaaaga
     1981 ctatggagtg gtttacagtc ttcccaaaac ccaaatagaa cttgaaataa aagccaacaa
     2041 agtcaactat actccgggag aattcagcaa atatgctgat cgttacctgc gactgaccaa
     2101 cgtctccgcc gaccctgaag agtactggga actggctagc gtaaaagtga aatccgtagg
     2161 tgtgcccaac agcgaaacta cgtatttcgt aaaattgaag gataagacag tagcaccgct
     2221 catggaactg acagaggatg gcattgtgaa aacgatcaat gttccttaca gcaatagcag
     2281 tgtaggcaaa aaagctgctc ccgcccccgc agtcctccaa aagaaagcga atcctcgtga
     2341 attcctgacc gaggagattc tgatggccag ctctaccgcc aagatggccg agctggtggc
     2401 taaagagatc tataacatcc gcgaaagcaa aaatgcctta ttgcgcggac aggctgacaa
     2461 tatgccttca gacggagcac agcttaaaat tatgctcgac aatctgaatg cacaggaaga
     2521 agccatgacg caaatgttct ccggcacctg caacaaagaa gagagaacat tcactgtccg
     2581 ccttacccct gacaaggaat tcaacaatga agttgctttc cgcttctcga agaagttagg
     2641 tgtagttgcc aacaatgatt tggcaggaac tccgttttat atcagtctga aagacctgaa
     2701 atcggtcaag atgccacagg aagatggtaa gaagaagaaa gatttggatg gaatcgccta
     2761 caacgtcccc ggacaagcta tggttacact gaccgacggt aaaaagaaac tttacgaagg
     2821 tgagcttcct attactcaat ttggtgtgat agaatatctg gctccggttt tgttcaacaa
     2881 gaattctacc atcaaagttt attttgatcc gaatacggga ggattgctca aagtggacag
     2941 agaagaaggg aaatagaaaa acgaggaagt aaacttctaa aaaacaaaga atatggttgg
     3001 tgaaggacat gcattcgaca tgatacgccg aataaaagag ggacgggaag cttcccgcct
     3061 acgtcgtgaa cgtgctaacg ataagttgaa gcatctaaac cgtgcaaacg aaccttatcc
     3121 actacccaac accacccccg aagaaatgga acgtatcatc cacgactcgg agaaaaagaa
     3181 agagaaagac agcaattatt ttgtttgggg aacgcttatt atcatggggg tcctgatagc
     3241 aattgccgtc atactttggg ctgtatttat caaataaata ataataagtt cctatttata
     3301 cgactggtat caccagtttt ataaatccat ctttctgcat ttgagaaaga taagccgata
     3361 cacgcgactc gtagccctct tcatattgaa agtggtctgc gagtttttct ataatctcac
     3421 gaacattgcg ttttccatct atcagttccc atacagccgt accgtgttct tccaatttca
     3481 catgaagttc tttcgacatt cctttcggca caaggaagcg ttgcatccac ggatatttaa
     3541 aacggggaaa ggagagcaca attgtctccc cttccctttc tgctgtaata tgttcactgc
     3601 gacagggaat gacctctaac aggttgattt tctctttggc agccatactt cttatttttt
     3661 atttcagagt attcatactg atactcttct gtttacacct tgatacaaaa ttcctttgtc
     3721 actttaggta ttgaatttcc cagttacttt tggatattcg cctcttccag accgtatccc
     3781 ttcttcttgt tctctgcctt taacatcaaa gccacaatca gagcaagcac accaaagaga
     3841 gcaaaaatag ccatcggcaa cgtgtagtca taagtctgtg caccgtctac taccggacct
     3901 ttgcaataag tattcaacac ccatccgatc aacaaaggaa cacccatcaa tccccagttc
     3961 tgtacccaga aaatcaatgc gtatgcggta cccaactgtt tttccggaat aatcttcgga
     4021 acagacggcc acatagctga aggcaccaac gagaaggcaa atcccaatat aatcatgatg
     4081 atagtagcaa accaccatat attcagtata ggcagagcga acatcgtatg cacaaaaata
     4141 agcatcactg atccgattat catcaacgta gctcccttac cgatacggtc ataaagcgag
     4201 ccgaacaacg gagtcaggat aatcgcacca atcggcaaca atccgggaat cgttcccgcc
     4261 aacttcggat ctacattata cttctgcacc atcaagtcgg cagcatactt gataaagggg
     4321 aatacagccg agtagaacaa tacacatagt aatgcaatca accagaatcc cttattcgta
     4381 atgatataca caatatcttt catacggaac ggttcttccg gttccaatcc ctctgcatcc
     4441 aaagaagcat ccaacttctt atcatagaaa gtataaagga agaaagcaat cgtacccacg
     4501 cacaacataa tcagacaaaa caaaatcgga gcaggaatat tggtatggaa tgtgccactc
     4561 tcatccgtag atccgaagaa gtcggccaaa ggaaccgtga gcaccattgc cagagttgtt
     4621 ccgatacgtg ccgtagccat ttcaagtccc atagccaatg ccatttcctt acccttgaac
     4681 cattttacga taattttgga aactgtgata ccggcaattt ccacacctac accgaagata
     4741 gcatacccca atgcggccag ggttacctgt gttttgaatc caaagagcat ggcaccttcc
     4801 ggaaaagtag tagaaatcgc atagtatttc aatccacaac caaacaccat caataagcaa
     4861 gcccccattc cggtgaaacg aactcccatc ttatccaaaa tgataccacc gaaaatcagc
     4921 atcaacagga atacattaaa ccacccgtaa gcgcttgtga agaaaccata atcaagactg
     4981 tcccatagta gttctttctc aagcatgggt tttagaggag acattacgtc ggtgaggaaa
     5041 tagccgcata gcatagtaaa tgcgaccaat gctagaacac tccatcggag tacggcggag
     5101 tcattcaatt tctgtttcaa atgttctgtc attgttatat ttaaaaaagt agttaataat
     5161 cttcatacga ccaacaaagg tagttaaatc tcgtttgttt ctatcaaaaa gagattgttt
     5221 ttacaagaaa aagttaagtg cggattacac tgaccacgcg gaagattgaa aatccgtgta
     5281 atctgcgtaa tccgcactta aatatcaaag aaatgcagca tccgtctgca ccttcccatt
     5341 aatggtttta ccccaaagtc ttacctgaca acggagtgaa ttactctgct gcaggagcag
     5401 gagtttcagt agccggtgcc ggagtttctg tagcaggtgc attggtagca ggagcttcag
     5461 tttgcggcgc agccgtacct gcgggtaagt tatacgggtt agtctgttgt tctttctgtg
     5521 cctgttccaa cactgcgtct ttagcaacag cagagcgagg aactacataa gcagtagcaa
     5581 tgctcattac caccatgaag atagctaagc cccatgttgc tttttccaga aaatctgtag
     5641 tcttgcgcac gcccatgatg gcgttagatg aagagaaacc agaagcaagt ccgcctcctt
     5701 ttgagttctg aatcagcacg atgaaacaca tcaacaaggc tgcaataacc attaagataa
     5761 cgaataataa gtacattttt agttattttg aattagcgtt aataatcaat ttctccaaaa
     5821 atctgatttg gtctgcaaag taagcatttt tttttggata tttcaagctt aattttttaa
     5881 ttatttcaag agcttttgaa tatcgttgct gtttaacata gatttttgcc aaagtttccg
     5941 taaaacagct gtcatcttcc tcttcttcct tcattgtttc ttcttcggta agttcgtccg
     6001 aagaggttgg cgaagatggc atttcttctc ttaaaggttt cttgcagagg ggagagtcgc
     6061 tctcgctctt ttctataaag tcgtcaatca gttcgtagcc tttgagtttg ggcgtttctt
     6121 cggccgactg ttccgtggcc ggagtctcct ccaaaagata agaggtgtaa tccatcgaat
     6181 agtcgaagct ggtgcgggca gtcacctctt cgggtactgt agacaagaaa gcgtcgatca
     6241 atgctaatgt gcggtctacg gacggttcgt ctttcagcac ctccgtgaga ggtactccct
     6301 ttttccgtgc ctgcacatca tagcggtcac cttcaatcaa ccggaacaac tgccgtctgt
     6361 ctgcaatgta aagaactgct ttccgcagtt ctccaccgaa actaatatca tggagaatat
     6421 acagattctt cagatacagc agacgaagtg actgaaaata cggatacctc gcaagaagat
     6481 tgcgcagttc gtacaaagta tccctattca gcgtctcggg atgctgaatc cattgttgaa
     6541 agttaacaga agtcatttat attaccagtt tgctacagtt gcattaaaaa tttggtcggt
     6601 gatctcttta gacatttcag caatcaatcc gtcctgtacg gcagtcagca actggctaga
     6661 gtcgtaggta cggaacgcag aaaactgttg ttcaaagtct tcggcatgat tggtgttgtt
     6721 gacaaaacgt acattgacgg taatagtcaa cttcgtctcc gaagagtaac cgtcggcaga
     6781 tactgcctgg ttgtactgat tgtatcctgt gatttctccg tcaatctgca agtccgcatt
     6841 ctgattcggc ttgagcagtt gcagacgggt ctgccggatg aagatatctt tcaggtcctc
     6901 attgaatttg gttgctaacg gagcatatac atactccgac ttgatcggga agtcggctat
     6961 cgaaatggtc tttaccttat cataattgat agacgatccg ttaaacttat aggaaacagt
     7021 gcacgcaatg actaccaacg gcaagccgaa cagtaacaaa gggcgtatta ttttcttaat
     7081 ccaattcata ttcttttatt tttctataaa gtgtacgctc ggaaatattc aagtccttgg
     7141 ccgcactctt ccgctttcca tgatgcctct caagtgcctt gcgtatcatt tctttctcca
     7201 cttcgtccag tgacaaaggg gattcttcta catattcttc cgtgtcttgt atgtcatcat
     7261 catccttgca aaccgtaggc tgcatggtgt gaatgatagc aggtaccgaa ggttgatgcg
     7321 ccgtcactac cggagtagta accaccgttc ccatttgtcc tacctgcccc acctgtccgg
     7381 cacgttccgc catcaggttg tgcaccatct tcttcagctc cgccacttcc tggcgcatat
     7441 cgaacagaac agaataaaga atctcccgtt cgctctcaaa gcctttactc tcacgcgttc
     7501 ccatcaacgc gggaagacgt tgcgtatttt gtgcaggaag ataattctgc aagatagcag
     7561 cagagatctc cctattggtt tcaatgatag atatttgctc ggtgatgttc ttcaactgac
     7621 gcacgtttcc gggccacggg taagccaaca actctttctt cgcatcctcc gtcaactgaa
     7681 tagcgggcat ccggtatttc tctgcaaagt ctgcggaaaa cttacgaaac aacaaaagta
     7741 catcgtcacc acgttcacgc aaaggcggta tctggatagg caccgtattc aaccggtaat
     7801 ataaatcttc acggaaacgt ccttctgcaa tcgcttgtgt aagattgacg ttggtagccg
     7861 ccaccacacg cacatccgtt ttttgtactt tggacgaacc tactttcata aactcgccac
     7921 tctccagtac acggagcaaa cgtgcctggg tagacatcgg caactcccct acttcatcaa
     7981 gaaaaatagt accaccgtca gcttcgccaa agtacccttt ccgttcgcca atcgcaccgg
     8041 taaacgcacc tttctcatgt ccgaacagtt cggaatcaat cgtaccttcc ggaatagcgc
     8101 cacagttgac agcaatatac tgtccgtgct tcctccggct atattgatga ataatctgcg
     8161 gaaaactttc ttttccgact ccactttctc cggtaatcag cacagacaaa tcggtaggag
     8221 ctacctgaat ggcaacatct atggcgcgcg acaatgcttc agtatttcca ataataccga
     8281 aacgctgttt cacttgttgt atctctgctt tcgtcatcac tcgtttttaa tcttcgtcta
     8341 ctgtatccag cttcagttta tcactatcgt cacgtttctc gtaatactgt ttacgcaacg
     8401 gattggcacg agccactttt tcccgctgac gattacggaa cacgtcgatg gcaacataga
     8461 ttgcctgacg gaaagaatct tcacaagcca ctcccttgcc tgcaatatcg tatgccgttc
     8521 catgagccgg agaagtacgt actatcggca ggcctgccgt atagttcacc ccgtcttcca
     8581 tagccaaggc cttaaacgga gccagccctt gatcgtgata catcgccaga ataccgtcaa
     8641 aatgagtata attgcccgaa cccataaagc cgtcggccgc ataaggaccg tagcaaagga
     8701 ttcctttctc ttccatttct ttcatggcag ggataatcac ttcctgctct tccattccca
     8761 acaaaccacc gtctccggca tgaggattga gagagagcac cgcaatacgc ggagcgccga
     8821 taccgaaatc ctgtttcaga caacgatgga atatcatcag tttctcctga atcagttctt
     8881 tggtaatcgt agtcgcgatc tctctgacag ggatatgtgt cgtcaccaaa gccacccgga
     8941 agtcattctt catcaaaatc atcaatgact tatcaccatt acccagacgt tcttcgatat
     9001 attccgtatg tccggggaag gagaactctt ccgactgaat cgtatgtttg ttgatcggag
     9061 ctgttacgat aacgtctatc aacccttcgc gatattcttc gatggcacgt tccaaagccc
     9121 ccagcgcagc tttaccggct tcggggtcgg gtttggaaaa ttccactttc acctcatcat
     9181 ccgtacagtt caccacgctc aaacggttgt accccgcttc ggtagcagag ttgacaatgc
     9241 tgaaattggc ctgtatatcc agcgctttgc gatgataagc cgctactttc ggtgagccat
     9301 aaatgatcgg agtacatagt tccaacatcg tagggtcgga aaatgtctta agaatcacct
     9361 catagcccac cccgttaata tctccttggg tgatacctat ccttatcttg ttatcttcca
     9421 tgtttttatt tattagtttg ttccgcttcc ttagatgctt ctcccaatgg aatctgcttc
     9481 tgctgaactt cattcggaag tttcagtgta tacagagatg cttccatctg gcgtaccagg
     9541 ttgcgtttca ttttatcagg tgaataaaca aatatttctg ctgtaataat tcgttggttt
     9601 ttctcgtcca gacgagtatg agatacatac ggaccaccca taaagtcgcc cttcatacgc
     9661 cacaggccac gtgcttccat tgtgtagctg ttctgtacat tgatcggacg gacatcggtc
     9721 agcaaactat cggtcgacat ataaacgccc tccttgaatc cggggatatt ggctttcatc
     9781 acggagtcac gtttgtgcac aaaatattct ttggtaaacg tatccttgtc agtgtacgga
     9841 taagagtaca tcacaaagtt acggtcggca gtacctgtgt tggtagaagc ccagaagaaa
     9901 tcatccccgg tctttgaatt agccagttcg gcatccaccc agatgtcgca tccgaacaaa
     9961 ctgtccactt tctgcgaaat gaaattactg tgtttccctt ccaggaacgt aatctgacgg
    10021 ttcatctccg cacgggtaaa gaagtcgaca atcgtctttt tgttctcttc cacaaacttc
    10081 tcgaactctt cttcgttcgg agcctggata gtcaatatca tctgcggatt ggcatacacg
    10141 tccttcgcat atttgaacga ggctttcgta tatatatcct gtatatctac aataataatg
    10201 ttacgtatca acttcagcgt agaatcataa tctttcggcg aagtatacat aatccggaaa
    10261 gaaggttccg actgcggcaa accgggcata tcagcatcga gcgcatcatg taaagccctt
    10321 ccggcagcac gatcccaaac accgtgatct actacaacca aaagctcgta agcacgacca
    10381 ctagaggtgt gatttccttt cagaccacaa gatgcaacga caaaggctac caaagcgatg
    10441 cataaaataa aagagtactt tttcatgatg ttcggtttta tatattaact ttcattattt
    10501 ttctcctgtt tcgctgtcga cagcataccg caagcggcaa aaatatcttc gcccctggat
    10561 gaacggatag tggtgaaaag tccgtgtgac gtcagataat cacgaaaacg ggtcatcgta
    10621 tccatgtccg ctccctcgag gtctaccccc ggtatggcat gaaaacgaat cagattcacc
    10681 ctgcaatcca gcccgcgaag aagtttcagc aactctttgg catagacctg cgaatcattg
    10741 agccctttaa aaacaatata ttcaaacgaa agtcgacgtt gtttactaaa atcatagttt
    10801 tttaacagtt ccaccatttc ggtgattgaa aacgcctttt ccgccggcat taattcagca
    10861 cgctgaacgg tcagcggaga gtgaaggctg atggcaaggt ggcagtcatt ttcttcgata
    10921 aaacgctgca atcctttccg tagcccgaca gtagaaagcg tgatacgctt cggactccat
    10981 gcgtaaccgt aggtagcggt cagtagttcc aatgccttca atacctcatc caggttatcg
    11041 agcggctcgc ccattcccat cattacgaca ttagtcagtt tgtcccgttc cggcagcgaa
    11101 tgaatctggt ttatgatctg gctggcggtc aggttagctg tatacccctg tttgccggtc
    11161 atacagaact tacagttcat tttgcagccc acttgtgacg acacgcacaa cgttgcccgg
    11221 tcatcatccg gtatataaac cgactctaca aaatggttct cacccacttt ataaagatac
    11281 ttcaccgtac catctacaga gcgcatttca tctaccggag cttccgctcc cacctcatag
    11341 ttctgcttga gcaactcccg gtgtttcaat gacaaattag tcatatcatc aatcgaggct
    11401 accttctttt cgtaaagcca ggatgcaatc tgcttggcag caaagccggg catacccagt
    11461 ctttttgtca atgattgaag ctctacaaga gtcattccta aaaggggata tttagacatt
    11521 cttctttctg ttgatagttt atatctgcaa atgtaaggaa ataaagtcga tttccgtata
    11581 gcaggaatgt aaaagttaac aaaaaaggga agtatgcctc cgttatgatt caaccacgct
    11641 gatatattga agtagctttt gcgccatttc agaatcctcg ccattctttt tcacttcata
    11701 accgtacgcc tcacggaaac aagccagcgc ctcttcccgt tcattacaaa agctgtgcaa
    11761 aacccctaag ttctgacaag ccagaatcgt atcttcttcc tcccatccca gatatttctt
    11821 tcgcagttca agctctctga agaaagcctc tttcgccatt ggataattct ccaacttcac
    11881 ataagcctgt gctttgtaat aatataccag acaggaagca ttagggtcag catcatcgtg
    11941 aaaatccaaa gacgttgcaa tacgaatcac gttatcatag tctttattca tgtaatactg
    12001 ctgcataata tcacatctca atgcctcgta gcggacagtc agttccgcca gacgcggttt
    12061 ttcgctgaaa tacatttcat gcagaagaga ctcacggaag aataaagtag acgcctgctc
    12121 atcgccacgt tcattcatca tccgtttgaa ttccctgcat agataataca actgtttatg
    12181 acaagcgacg atctgtcttt tgctgtctat ctgtatagca atgtccaacg cctgattcat
    12241 cagcatccat gcttcatcgt atcgtttgat ataataaaga catttaccct gcatacgcaa
    12301 acatttagcc actccaccag acagtctgcc attcaacgac tcgtgcattt cagctacttt
    12361 ccggaatttc tcggcagccc tctcttcctc atccttatag taatcacaat aagccagata
    12421 ttcggaaagt tcaatgactt ctgcctgact cttctcatca gcagaagccg catgataatc
    12481 aagcgcccta ttcaaatagg tcactgcttc attgtattgc tcattgtagt aatatgccag
    12541 agctagattt cggcaggtgt tggcaatctc cagttccgga gtcggtacta tgttttcctg
    12601 catcaccaat gctttcagga aacagtcgca tgccgtttcg tactcttcat tacgggcata
    12661 ccggcatccc tcattcatct tcaataccga cttggcaatg agtggcatgg cagcaccttc
    12721 catactcttc tcactcacag cagctgccgc cttcgtcaga tggaaagaac tgctcaagaa
    12781 agtagccata tcattagcaa tgacaggaat taaaaaagaa tcgatctcat caaagtccaa
    12841 ttcagcatag acttcaggcg taacttcagg attgtcgttc atgatcgcct tccagctatc
    12901 ttccaacaga gaacgattcg tgcgatacag aatctcgaaa atctccacat cacaaatcca
    12961 atccttcaat atatcccatt cttgcatctt atagcattga taggtaatct ccactttata
    13021 gcgatacgaa tcatggtagc agaactgttt catgcgatag ttataatcgg caaaagtcaa
    13081 cggatgggaa aggatctctt cctcatccag cagagcggaa ataatttcat ggcgactatc
    13141 atctatacat tcgtcatctt gagcgaaata gcgttcgatc gcctctacca tttgtgtatc
    13201 accaatgcaa tatcgtcctc ctttgttggt gagccagctg ctcatttcca ctctcaactg
    13261 cgaccaaagt atctgattaa tgtctgccat gctcttcact tcatcttcgg taaatccttc
    13321 taaagtaagt gaaagcatca gaagcgttct tccaatctct tcggaaccat aatcagccga
    13381 caaacgccgt agcacactgt catagaattg cccaacctca ttgagccggc aatatccacg
    13441 catatattca ttgagagcat cgtactgacc gaacgaaacc agctcgttga gcaatacact
    13501 taaacagcgc ggttgttcag ccagca
//
