LOCUS       gnlProkkaLGFJAAOD_29   16712 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LGFJAAOD_29.
ACCESSION   gnlProkkaLGFJAAOD_29
VERSION     gnlProkkaLGFJAAOD_29
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 02:23:06
            Original ID  :: gnl|Prokka|LGFJAAOD_29
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16712
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..285
                     /locus_tag="ctg29_1"
                     /transl_table=11
                     /translation="MHFENALRERTALLMSHQNETVEFGSAYEKYFYLHYDKDGVFLYP
                     EEKTTVTEREISLCGYFVIITSERKIHEVPLYSGSVNVFEIPPFGASSK"
     protocluster    1..16712
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3874:6712]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3875..6712
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..16712
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16712
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             complement(431..853)
                     /locus_tag="ctg29_2"
                     /transl_table=11
                     /translation="MPRVGILVNIVGVLVISFLHKLLVNYKEGDIMFAKIGFRIKQARI
                     NAQITQDTLAELIGCSTSFISRLECGKVSTSLETLLNISQVLNIGLEELLCDFLNLPDS
                     VQTPTSYQILQIVNSLTPQQQGIVLQHLQGLLHWTE"
     CDS             876..1415
                     /locus_tag="ctg29_3"
                     /transl_table=11
                     /translation="MKLKNTWIQGDSNDTIENTGSNTSSMWMVIIRMLIKEYQVTKNDE
                     FLTAIQFCIYEHLGKRIECDKIKKMLVEDSDIRDFELYKILFEKEESIIKIKLNYNAIA
                     AAIGKWPISKYRKYTKNEVIKDIIEKVSNKSIGEYEYSVRYADGKKYISQIRLYIQENS
                     SYLCNVVYHKYYLIII"
     CDS             1424..2206
                     /locus_tag="ctg29_4"
                     /transl_table=11
                     /translation="MALYLLMFFEVTCLLGRRKMLRFVYVEDEKYFQKEVKTIIIQHYI
                     EKQMAVDIQIYNSAEMLNYDLQENKYYDVYMLDIGLEKKDDGLNLAKKIRKLQAHAIII
                     FITSHLEFALKGYDYAAFQFIDKQKIKEKIPEVLTCVDEKLALQNKNYYIISTNSRYIK
                     IPLEDIIYIYKEAKNCIFVCKNNETAYVRATIQKIYSDLNDEMFIFANRSYIVNVIHIR
                     KVDCKEVYLDNDDTIIISRNYSLKVKEEIHNYWRKHIH"
     CDS             2206..3510
                     /locus_tag="ctg29_5"
                     /transl_table=11
                     /translation="MNNLYKEIQFLLCVIEILGVFILLSIFLKKRKCIKGRKCIICFLV
                     FLLALVENFNRYIVYYSTTLTLFLIISIFIISLIFYKQNILMSLIIITNYFYVLSLFDM
                     LVISCIHSSVTYNIGLYIETTLDYPRILLMAVTRGLICSFVYIIYRKISIHHIENIRIG
                     KYIKFFIPVVILETAGLNGFEYIYIDSIDLTAQWIEFILLFILFVLLFYIYVIYRNEKE
                     KLLSTQILLESLEVNYNSVISLYKERENIYHDFKNHIIVISSLIEHEDYDEVKKYISNL
                     KSPISEIGGIVLSSNNLVDIIFNYKYFEAKEKNIKIVFDVDMLENYNFSMSENELCAVF
                     SNVLDNAIEACTNIVGFDPIIQVSLKKANDMLFFRVQNPCIQCQKNASGKFISTKDDKL
                     LHGIGLRSVTSVIEKYDGHIVYDIEGNSFVIDIMM"
     CDS             3599..3754
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_6"
                     /transl_table=11
                     /translation="MYKEVIRREELMEVIGNVEKEKKILLEIQNKNTEQKITQELTGAF
                     LTILCC"
     CDS_motif       3599..3649
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MYKEVIRREELMEVIGN"
                     /locus_tag="ctg29_6_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       3650..3754
                     /prepeptide="core"
                     /locus_tag="ctg29_6_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.40"
                     /molecular_weight="3848.5"
                     /monoisotopic_mass="3846.1"
                     /core_sequence="VEKEKKILLEIQNKNTEQKITQELTGAFLTILCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MYKEVIRREELMEVIGN"
                     /leader_location="[3598:3649](+)"
                     /alternative_weights="3866.5"
                     /alternative_weights="3884.6"
     CDS             3875..6712
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     617.7; E-value: 6.2e-187)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_7"
                     /sec_met_domain="DUF4135 (E-value: 7.4e-74, bitscore:
                     240.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.1e-58, bitscore:
                     188.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVKEIFEEIYNEGFGCYEDFDENILKNRNFIPFYIPFIKYTLKK
                     IDKNIPQSVFWRRETINDIARGVFNRLEPLCIRTLILEIKFCKENKVIQASDIKIEYEI
                     FLQECLKNLSYMEGFWRIYPLLLCEIVEACNEYVLLLRNMVERLEKDRKEIIRELCNGK
                     EFEMLVRVESDMADFHDYGETVVKIVLDNGITIYYKPQKNNLKKIYLEYLKVLYKDQKL
                     DSYDYKIVFQSKYSWEKEVYYKECATETEIKNYFTRLGINLFLCYAIGAADIHYENVIA
                     AGEFPVLIDMEVIKRNKNSNIMRDIEKFMSDSVLNIGILPVYMKGTNNSVFNAGILRNE
                     ESCKTIYDVPVVANSQTSDIRITYKKSVVNTGQCLPKINGKGVKLEKYLYFFIKGFYNS
                     FCIWKNRRLEKKIKVSLKKENFRYILRATQEYSMILLIIRNPEYLCNKEKRNKLVDLLL
                     QQSEEYNVQIIEYEKKCLLKGNIPYFSHNFADYNLYCEDAVIQDYFSNSIELRGRNKKE
                     NILNQIRLIIVASNGLLEGGVKNTYIMNKLLDLKQYTVDNSKSYIDLAIDKMMCRIMKN
                     NLLAEEKSIGWWSIETIDNIWNVVPMNNYLYCGMAGMCILFHIYYLKNPIASIKTVIKQ
                     IDEQMFCYTKSLSNDKKEMGAFTGEYSIVYMYQYVYTITKNEIYLHYAEQHCSKLLKMD
                     LASRGYDFVSGWSGIIKTLLNMYKLTNNEKFIYDAEHRINLMIEEIEAECNLYDRGKSN
                     RMWAGLAHGLSGAEICLCNYQKITKRDKYMKYISKMIEYENKLYDSKIKNWKDIRGINS
                     GDGVAWCHGAAGILLARTVLQEKEEIKDICKKDIEKAMEKIMTKGLRKGFCLCHGNSGN
                     VHIMLESALKQGNDKIVKICEIYLHNMAKKIYENKLELLPQERFDFGLMNGIAGFIYAL
                     LSRKVKLPEILLLDI"
     CDS             complement(7283..7495)
                     /locus_tag="ctg29_8"
                     /transl_table=11
                     /translation="MEALSIYLQENMHMESICVFPTGGLAQKYRPCRTASGTGGRLEQD
                     YPGLSKVDIISIVKALEALSSYVTL"
     CDS             7742..7867
                     /locus_tag="ctg29_9"
                     /transl_table=11
                     /translation="MYLKFEVDIPKIPGKINYVKKGGTVYVRYVLERVYHPEKKI"
     CDS             7827..8525
                     /locus_tag="ctg29_10"
                     /transl_table=11
                     /translation="MCSKEYIIQRKKYNVPEQRIIGKRSENNPDRMLPNETFVKYFGGQ
                     EMPEQKAGQTRSSCLRIGTFLVIQKILNGYKLPEILEKYLGKKETGLFLDLAAYSLISE
                     NNAAQYYPSYAYSHPLFTKQMHIYSDSKVSDFLAGLTDDQRIGFVNGWNENRDHREKIY
                     ISYDSTNKNCQAGDLRFVEFGHPKDDRGLPAFNYSIAYDTYNKEPLFYEQYPGSIVDIS
                     QLQYMLKKAE"
     CDS             8592..9575
                     /locus_tag="ctg29_11"
                     /transl_table=11
                     /translation="MDECGYDFVIMVKGMSESVRRVILENKGEFENIRKYNIRKYKTFG
                     KTIKKKLYISDEKERYFHIYYSDQKACAEHEQIEAKIDRMTKYLNGLKGEKATVGDGYK
                     KYFKLEIYEDDGTIICARERTEVIQEEINLCGYFVIVTSRQMTAEEALELYKSRDVSEK
                     LFRGDKSYLGNRSLRVQSDEAAGAKIFVEFVALIVRSRMYVLLKDEMEKLDKKPNYMTI
                     PAAIRELEKIELVRQIDGKYRMDHAVTATQKIILKAFDMDAEQIQKQEETVLKVKEKYD
                     SEMMKLKDLYAKRNEEKKKELLKAVENSTKTYEEIMAFICSEGEIN"
     CDS             9834..10742
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176:alkyl hydroperoxide reductase subunit (Score:
                     246.1; E-value: 1.1e-74)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_12"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.4e-39, bitscore:
                     125.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKVIIIGAGPAGISAALYAVRGNLDPLVINNGIGALEKAEKIEN
                     YYGLEHPLSGQELYDTGIAQAKALGVRILDAQVLGVGGFDTFVVKTTEGEFETQSLILA
                     TGSKRAAPKIPGVKEFEGKGVSYCAICDAFFYRGKDVAVLGNGDFAMHEAKELSNTAST
                     VTIYTNGEEPEFTPEENISVNTMKIQSVEGDDLVSGIRLAPDVQAQEINGEAGQQVNDF
                     CPADGVFIAMGTAGSTEIARQMGAELTEKGNIKVNENMETTIPGLYAAGDCTGGLLQVA
                     KAVYEGAQAGINAGKYVRSLK"
     CDS             10769..11071
                     /locus_tag="ctg29_13"
                     /transl_table=11
                     /translation="MAKEITTANFETEVLKSEKPVLIDFWATWCGPCMRQGPVVEELAE
                     EGYAVGKVDVDQNMALAQQFRVVSIPTLILFKDGAEVKRFVGLTSKEELKSALEG"
     CDS             11078..12754
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 182; E-value: 3e-55)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_14"
                     /sec_met_domain="PF04055 (E-value: 4.3e-18, bitscore: 57.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILLVACNAKYIHSNLAVYDLQAYASDYADHIVLKEYTINQQKD
                     DIMRDIYLEHPDVVCVSCYIWNLSFVKELMADLIKILPGADFWAGGPEVSYDAEKFLTE
                     NSEFKGVMVGEGEETFKELAGYYVEKNPQDLKDMTGICYRDGDQIIHNGWRQIMDLSSI
                     PFIYKDLSEFKNRIIYYESSRGCPFSCSYCLSSIDKKLRFRDTETVKKELQFFIDNKVP
                     QVKFVDRTFNCKHDHAMAIWKYINEHDNGVTNFHFEISADLLREEELQEMSTMRPGLIQ
                     LEIGVQSTNPDTIKAIHRTMDFEKLKGIVDRIHSFGNIHQHLDLIAGLPYEDYDSFRHS
                     FNDVYALKPQQLQLGFLKVLKGSHMMEMCREYGIVYKTQEPYEVLSTKWLDYDHVLKLK
                     TVENMVEVYYNSGQFQNTLEYLENFFQDAFSIYERLGSFYMEKGYGDVSHTRMRRYEIL
                     LEFLEDVPEISMDQVKDQMVYDLYLRENLKSRPGFARDQKPFERQVWDFRKREKVAKNA
                     HVEVFADGTVLLFNYADRDPLTNNAHVTDVTKDVFENLNRD"
     CDS             12769..12873
                     /locus_tag="ctg29_15"
                     /transl_table=11
                     /translation="MGMFNPKNRKVITAIIAIILVLAMVVPTVLSLIV"
     CDS             12894..13490
                     /locus_tag="ctg29_16"
                     /transl_table=11
                     /translation="MRLGQAAMEALRAEITGCLKPGDELVVACPVALKGTSVIAKNKKD
                     KLAERFSAGFIQNCVSLWDAYGAGSIVWKIAQEADASALYAMGEGGFLSALWKMAEASE
                     VGLEADFRKVPIRQETIEVCEIFDLNPYKLQADGAVLIGIRGGEALVQRLRNEGFMAEV
                     IGQTNSGNDRLLYSGGSARYLERPAEDELQQLFKE"
     CDS             13561..14061
                     /locus_tag="ctg29_17"
                     /transl_table=11
                     /translation="MAKLNIVLHEPEIPANTGNIGRTCVATGTRLHLIEPLGFSLSEKA
                     LKRAGMDYWKDLDVTTYLDFEDFLEKNPGAKIYYATTKAPQTYTDVHYEEDCYIMFGKE
                     SAGIPEDILVNNQETCVRIPMIGDIRSLNLSNSVAIVLYEALRQNNFDHMNLEGHLRNY
                     DWK"
     CDS             14089..14658
                     /locus_tag="ctg29_18"
                     /transl_table=11
                     /translation="MPNTTKAALEESLKRLLLKKPLDKITITDITTDCGISRMAFYYHF
                     KDIYDLVEWSCVEDGTKALQGKKTSESWTEGLTQIFEAVLENKPFIMNVYRNVDRERIE
                     NYLFKLTYDLIVGVVEEKSKGLNITEEDKKFIADFYKYGFVGIMLEWIREGMKENIEDL
                     VRMMDLTLHDTVTTSIHNFQKNNMEK"
ORIGIN
        1 gagcattttg aaaacgcact gagagagcgg acagctttgc tgatgtcaca tcagaatgaa
       61 acagtagagt tcggttcggc ttatgaaaaa tacttttatc ttcactacga caaagacggt
      121 gtgtttttat atccggaaga aaaaacaact gtgacagaac gggaaatatc attatgtgga
      181 tactttgtta ttattacatc cgaaaggaag attcatgaag tgccgcttta tagcggctca
      241 gtaaacgtgt ttgagatacc gccattcggg gcgagcagta aatagccctt tggagagcca
      301 atatcaaacc accagtttaa ctggtggctg atgactagat tttagtaaag attaactaaa
      361 atctatattc gaggacaaaa acaaactaaa taaggacaaa gtgcaaatat tagaaagaat
      421 atgatataat ctattcagtc caatgaagca gtccttggag atgttggaga acaatgcctt
      481 gttgttgtgg cgttagcgaa ttaacaattt gtagaatttg ataggacgtt ggagtttgaa
      541 cagaatctgg aagatttaaa aaatcgcata ataactcttc taatccaata tttaagactt
      601 gagaaatatt tagaagtgtt tctaaacttg tgcttacctt accacattca aggcgactta
      661 taaaactggt agaacaaccg attagttcag ctaaagtgtc ttgggttatt tgagcattta
      721 tacgagcttg ttttattcta aatcctattt ttgcaaacat aatatctcct tctttatagt
      781 ttaccagtag tttgtgtaaa aatgaaataa ctaatacgcc tacaatattt accaatatgc
      841 ctactcgagg caaaatataa atggaggtgt gaaaagtgaa attaaaaaat acgtggattc
      901 aaggagatag caatgatact atagaaaata ctggaagtaa tacttcatca atgtggatgg
      961 ttattataag aatgttaata aaagagtatc aggtaactaa aaatgatgaa tttttaacag
     1021 caatacaatt ttgtatatat gaacatcttg gaaaaagaat agaatgtgat aaaataaaaa
     1081 aaatgttagt tgaagacagt gatataaggg attttgagtt atataaaata ctatttgaga
     1141 aggaggagag tataattaaa attaaattaa attataatgc aatagcagca gcaataggga
     1201 aatggcctat tagcaagtat agaaagtata caaagaatga agttataaaa gatattatag
     1261 aaaaagtatc taataaaagt ataggggaat acgaatatag tgttcgttat gctgatggaa
     1321 aaaaatatat atcgcagatt agattatata tacaggaaaa tagtagttat ttgtgcaatg
     1381 ttgtttatca taaatattat ttaataatta tatagaaaaa ataatggcat tgtacttgtt
     1441 gatgtttttt gaggtgactt gtttactggg aaggagaaaa atgcttcgat ttgtctatgt
     1501 ggaagatgaa aaatatttcc aaaaagaagt aaaaactatt attattcagc attatataga
     1561 aaaacaaatg gcggtagaca tccagatata taattctgct gaaatgttaa attatgatct
     1621 acaagagaat aaatattacg atgtttatat gctagatatt ggattagaaa aaaaagatga
     1681 tggactaaac ttagcgaaaa aaataagaaa attgcaggca cacgccatta ttatttttat
     1741 aacatcgcat ttggaatttg cattaaaagg atatgactat gcagcatttc aatttataga
     1801 taagcaaaaa ataaaagaga aaattccaga ggtgctgact tgtgtagatg agaaacttgc
     1861 attacaaaat aaaaattatt atataatcag tacgaactct agatatataa aaataccatt
     1921 ggaagatata atatatattt acaaagaggc taaaaactgt atatttgtgt gtaaaaataa
     1981 tgaaacagct tatgtaaggg caactataca aaagatatat agtgatctta atgatgaaat
     2041 gtttattttt gcaaatcgaa gttatatagt taatgttatt catattagaa aagttgattg
     2101 taaagaggtg tatttggata atgatgatac tattataata agtagaaatt attctttaaa
     2161 ggttaaagaa gaaatacata actattggag gaaacatatt cattgatgaa taacttatat
     2221 aaagaaattc aatttttgtt atgtgtaata gaaatattag gggtttttat tttactttcc
     2281 atttttttaa aaaaaagaaa atgtattaaa ggaagaaaat gtattatatg ttttttggtt
     2341 tttttgttgg cattggttga aaactttaat agatatatag tttattattc tacaactcta
     2401 acattgtttt taatcataag tatatttatc atctcactaa tattttataa acagaatatt
     2461 ttgatgtcgt tgattataat tactaattat ttttacgtat taagtttgtt tgatatgtta
     2521 gtaatatcgt gtatacattc aagtgtaaca tacaatatag gattgtatat agaaacgaca
     2581 ttagattatc caagaatttt gttgatggct gttaccagag gcttaatttg tagttttgta
     2641 tatataatat atcgaaaaat aagtattcat catattgaaa atataagaat aggaaaatat
     2701 ataaaatttt tcataccggt tgttatatta gaaacagcag gattaaatgg atttgaatat
     2761 atatatattg attctattga tttgacagct caatggatag aattcatatt attatttata
     2821 ttgtttgtac ttttatttta tatatatgtg atttatagaa atgaaaaaga aaaattatta
     2881 tctactcaaa tattattgga atcattagaa gtaaattaca attctgttat tagcttatat
     2941 aaggaaagag agaatattta ccatgatttt aaaaatcaca ttattgttat tagcagttta
     3001 attgaacatg aagactacga tgaggtaaaa aaatatatat ctaatttaaa aagtcctata
     3061 tcagaaatag gcggtattgt attatcatca aataatttag ttgatataat atttaattat
     3121 aaatattttg aagcgaaaga gaaaaatatt aaaattgtat ttgatgttga tatgttagaa
     3181 aactataatt ttagtatgag tgaaaatgaa ttatgtgctg tatttagtaa tgtgttagat
     3241 aatgcaatag aggcatgcac aaatattgta ggttttgatc ctataataca ggttagctta
     3301 aagaaagcaa atgatatgct tttcttcagg gttcaaaatc catgtataca atgtcaaaag
     3361 aatgcaagcg gaaaatttat ttctactaaa gatgataaat tattacacgg aataggttta
     3421 cggagcgtaa caagtgtaat tgagaagtat gatggtcata tcgtttatga tatagagggt
     3481 aatagttttg tgatagatat aatgatgtaa atagagtata tgataaaaac atgtaaaatt
     3541 tgtttataga cagataattt ctacatgttt tatataaaat attacatagg aggtagttat
     3601 gtataaagaa gtgataagga gagaagaact aatggaggta ataggaaatg tggaaaaaga
     3661 aaaaaagata cttttagaaa tacaaaataa aaatacagaa caaaagataa cgcaagaatt
     3721 aacaggtgct tttttgacta tattgtgttg ttaatataca ggtgaaagtg ataagaaagt
     3781 gttactttca ccttttttat ataattgaaa cattagttat tagaattaaa atcgattagg
     3841 agagagcaat ttatttgagg tgatatataa agttatgagt gtaaaggaga tatttgaaga
     3901 aatttataat gagggttttg ggtgttatga agatttcgac gaaaatatat tgaaaaatcg
     3961 aaattttatt ccgttttata ttccatttat aaagtataca ttaaaaaaga ttgataaaaa
     4021 tattccacaa tctgtctttt ggaggaggga aactataaat gatattgcaa gaggagtgtt
     4081 taatcgtcta gagcctttat gtatccgtac gttaatttta gagataaaat tttgcaaaga
     4141 gaataaagtg atacaagcga gcgacataaa aatagaatat gaaatatttt tacaggagtg
     4201 tcttaaaaac ttgtcatata tggagggatt ttggagaata tatccattgc tgttgtgtga
     4261 aatagttgag gcttgcaacg agtatgtatt attgttacga aatatggttg aacgtttaga
     4321 aaaggatagg aaggaaatta ttagagaatt atgtaatggt aaagaatttg aaatgctagt
     4381 aagagtcgaa tcagatatgg cagattttca cgattacgga gagacagtgg tgaaaatagt
     4441 gttagacaat ggtattacaa tatattataa gccacaaaaa aataatttaa aaaaaatcta
     4501 tctggaatat ttgaaagttt tgtataaaga tcaaaaatta gactcttatg attataaaat
     4561 tgtatttcaa tcaaaatata gttgggaaaa agaggtttat tacaaagaat gcgctacgga
     4621 aactgaaata aaaaactatt ttactcgttt aggaataaac ttgtttttgt gttatgcaat
     4681 aggagctgcg gatatacatt atgaaaatgt aattgctgcg ggcgaatttc ctgttttgat
     4741 tgatatggaa gttattaaaa gaaataaaaa ttctaacata atgagagata tagaaaaatt
     4801 tatgagcgat tcggtgttaa atatagggat tttacctgtt tacatgaaag gaacgaataa
     4861 ctcggtattt aacgcaggaa tattaagaaa tgaagaaagt tgtaagacga tatatgatgt
     4921 tccggttgtt gctaattcac aaacatcgga tattcgaatt acgtataaga agagtgtagt
     4981 aaatacgggg cagtgtttac ctaaaataaa tggaaagggg gttaaattag aaaaatattt
     5041 atattttttt attaagggat tttataatag tttttgtata tggaaaaata ggagattaga
     5101 gaaaaagata aaagtaagtt tgaaaaaaga aaatttcaga tatattctta gagcaactca
     5161 agaatattcg atgattctgc tgattataag aaatccagag tatttgtgca ataaggaaaa
     5221 aagaaataag ttagtagatt tgttattaca acaatctgaa gaatacaacg tacaaataat
     5281 tgaatatgaa aagaagtgtt tattaaaagg gaacatacca tatttttcac ataattttgc
     5341 ggattataat ttatattgtg aggatgcagt aattcaagat tatttttcaa attcaataga
     5401 attaagggga cggaataaaa aagagaatat tttaaatcaa attagactca taatagtagc
     5461 aagtaacgga ttattagaag gcggagtaaa gaatacttac ataatgaata aactgctaga
     5521 tttaaaacag tatactgttg ataacagtaa gtcatatatc gatttggcta ttgataaaat
     5581 gatgtgcaga attatgaaaa acaatctatt agcggaagaa aagagtattg gatggtggag
     5641 catagaaaca atagacaata tttggaatgt cgtgccaatg aacaactatt tgtattgcgg
     5701 aatggctgga atgtgcattt tgtttcatat ttattatttg aaaaatccta tagcaagtat
     5761 taaaacagtg attaaacaga tagatgaaca aatgttttgt tatacgaaat ctttatctaa
     5821 tgataagaaa gaaatgggtg catttacggg tgaatattct atagtatata tgtatcaata
     5881 tgtgtataca ataactaaaa atgaaattta tttacattat gctgagcagc attgtagtaa
     5941 attgctcaaa atggatttgg catcaagagg atatgatttt gtatctggtt ggtcaggaat
     6001 aataaagaca cttttgaata tgtacaaatt gaccaataat gaaaaattta tatatgatgc
     6061 tgagcatagg ataaatttaa tgatagaaga aatagaagca gagtgcaatt tatatgatag
     6121 gggaaaatca aataggatgt gggcaggatt agcgcacgga cttagtggtg ctgagatatg
     6181 tttatgtaat tatcaaaaaa ttacaaaaag agataaatat atgaaatata tatcaaaaat
     6241 gatagagtat gaaaataagc tatatgattc aaagattaaa aattggaaag atattagagg
     6301 tataaatagt ggggatggtg tagcatggtg tcatggtgcg gctgggatat tgttagcaag
     6361 aacagtttta caggaaaaag aagaaattaa agatatttgt aaaaaagata tagaaaaagc
     6421 aatggagaaa attatgacca aagggttgag aaaaggattt tgtttatgtc atggtaattc
     6481 gggaaatgtg catattatgt tagaaagtgc attgaagcaa ggaaacgata aaatagtgaa
     6541 aatatgtgag atatatttgc acaatatggc taagaaaata tatgaaaata aattagaatt
     6601 attaccacaa gaacggtttg attttggttt aatgaacggg atagctggtt ttatatatgc
     6661 tctattatca agaaaagtaa agctaccaga aattttatta ttagatatat agtagcaaaa
     6721 taaaagtctt cttttgctaa ataatttata tcgagaatat ttgctaaata atgattatat
     6781 tgaatgtaga catagaaaag catatttcag ttatcgtatt aaataaaaga tagctaaata
     6841 tgctttttac atgagtgtga actctgcaaa aaagttacac taaatccgct acaccgcata
     6901 aatactagat tttcatggat ggttttagtg taacagttac actaaaactg cactaaaacc
     6961 aatttggaga aaatggcttg ttttcaaact ttttagccat ttagtgtaac ttttatgaaa
     7021 agttcagaat gagaagaata gattagatat tacattgaaa atttaaatat accgaacatt
     7081 ttatgtgttt cattcgggat aaggatgaag gagaaagacc tttgctctta tcttcaaata
     7141 ggaaggaggt gaactctatg tgttgctgat ttctcagttt gtcactaatc agatttgctc
     7201 ccatgtcaca gatctgctaa gttttgtgtc attggcattt ttgtgcaatc cggcagattt
     7261 cctgccggat tatctgtttc atttacaatg ttacatatga gctgagtgct tcaagtgctt
     7321 ttacgatact gatgatgtcc acctttgaca gccccggata gtcctgttca aggcgtcccc
     7381 ctgttccaga agcagtccga cagggacgat atttctgtgc caatccccca gttgggaata
     7441 cacagatact ttccatatgc atattttcct gcaagtagat ggaaagtgct tccacgggcg
     7501 gtcacctcaa actcatttct gtttattgtg aactctgcat tcgagttcca ctaaaacttg
     7561 taattctggc taacattttg caaaagcaag taacttcctg aaaaagtgac actcaaaaaa
     7621 tagcagattg taaaaaaact tgaaaaatag ggattttttg gcataaaatc ttgaaaaacg
     7681 ggaaaacagg agtaaaatat tgagtagaaa gtaacactcg atatttgaag ggagatatgc
     7741 catgtatctg aagtttgagg tagacattcc gaagataccc ggaaagataa attatgtgaa
     7801 aaaagggggt acagtatacg tcagatatgt gctcgaaaga gtatatcatc cagagaaaaa
     7861 aatataatgt tccggagcag aggatcattg gaaaaagatc agaaaataac ccggatagaa
     7921 tgctcccaaa tgaaactttt gtaaaatatt ttggcggtca ggagatgcca gaacagaaag
     7981 ccggacagac gagaagcagt tgtctgcgaa tagggacttt tctggtgatc caaaagatcc
     8041 tgaatggata taaactgccg gagatcctgg aaaaatatct tggaaagaag gagacggggc
     8101 tgtttctgga tctggcagct tattctctta tcagtgaaaa taatgccgca cagtattatc
     8161 cttcctatgc ttacagccat ccgcttttta caaagcagat gcatatatac agtgattcaa
     8221 aagtgtcaga ttttcttgca ggacttacag atgatcagag gatagggttt gtaaatgggt
     8281 ggaatgaaaa cagggatcac cgggagaaaa tatatatatc ttacgattcg accaataaga
     8341 actgtcaggc aggggatctg agatttgttg agtttggcca cccgaaagat gaccgtggac
     8401 tgccggcctt taactattcc attgcgtatg atacatataa taaagaaccg ttgttttatg
     8461 agcagtatcc tggaagtatc gtagatattt cccagctcca gtatatgtta aaaaaagcag
     8521 aatgatacgg atataagagg gtcggattta tcctggacag gggatatttt ggcagggaaa
     8581 acatccggta tatggatgaa tgcgggtatg attttgtgat catggtaaag ggtatgagtg
     8641 aatctgtgag acgggtgatt ctggaaaaca aaggagaatt cgagaacatt cgtaaataca
     8701 atatacggaa gtacaagaca tttggaaaga caataaagaa aaaactctat atatcagatg
     8761 aaaaagaaag atattttcat atttattatt cagaccagaa agcgtgtgcg gaacatgaac
     8821 agatagaggc aaaaatagac cggatgacga aatatcttaa cggtttaaag ggagaaaaag
     8881 cgaccgtagg ggatggatat aagaagtatt ttaaacttga aatatatgag gatgatggga
     8941 cgatcatatg cgcaagggag aggacagaag tgatccagga agagatcaat ctgtgcggat
     9001 attttgtgat cgtaacgtca agacagatga cagcggaaga agctttggaa ctgtataaga
     9061 gcagggatgt atcagaaaaa ctgttcaggg gagataagag ttatcttggg aacaggagcc
     9121 tacgggtaca gtcagatgag gctgcaggtg cgaagatctt cgtggaattt gtagcactga
     9181 tagtaagaag caggatgtat gtcctgctga aagacgaaat ggaaaagctt gacaaaaagc
     9241 cgaattatat gaccattccg gcagcgatcc gtgaactgga aaagatagaa ctggtccgtc
     9301 agatagatgg aaaataccgt atggatcatg cggtaacagc aacccagaaa ataatcttaa
     9361 aagcgtttga tatggatgca gaacagatac agaagcagga agagacggta ttaaaagtaa
     9421 aagaaaagta tgattccgaa atgatgaaac tgaaagatct ttatgcaaaa aggaacgaag
     9481 agaagaaaaa agaactgctc aaagctgttg aaaacagtac aaaaacatac gaagagatta
     9541 tggcatttat ctgttctgag ggtgaaataa attagatttt ggactgtttt gatgagaaaa
     9601 gggcaatttg agtgttactt tttcaggaag ttcacgtaaa aaagctcttc gggtaggatt
     9661 gcactttgaa tatgtaaaaa tgaaccaaaa ttatccaaat aaaatcatgg atttttttca
     9721 gaaaacgtag tatagtaaca atagatgata ataagttact gagaacagag tgcacagtaa
     9781 cgatgatata tcacagtata ttgaaaacaa taacagagag caggtgacag aatttggaaa
     9841 aagtgataat cataggtgcc ggacctgcag gaatttccgc tgcgctttat gcagttcgtg
     9901 gaaatctgga tcccctggtg atcaataatg ggatcggtgc tttggaaaaa gcagagaaaa
     9961 tagaaaatta ttacggactg gaacatccgc tgtccggtca ggaattatat gatacaggaa
    10021 tcgctcaggc gaaagcactg ggcgtacgaa tattggatgc acaggttctg ggagtcggcg
    10081 ggtttgatac ttttgtggta aaaactacag aaggtgaatt cgagactcag agtctgattc
    10141 ttgcaacagg aagtaagcgc gctgcaccga agatcccggg tgttaaagaa tttgagggaa
    10201 aaggtgtcag ttactgtgca atctgcgatg ctttctttta cagaggcaag gatgtagcag
    10261 ttctgggaaa cggtgatttc gccatgcatg aagcaaagga attgtccaat actgcttcta
    10321 cagtaaccat ttatacaaac ggtgaagaac cggaatttac acctgaagaa aatatcagtg
    10381 taaacacaat gaagatccag tctgtagagg gcgatgatct ggtatccgga atccgtcttg
    10441 cacctgatgt acaggcacag gaaataaatg gggaagcagg tcagcaggta aatgatttct
    10501 gtcctgcaga cggtgtattt attgcaatgg gaactgcagg cagtactgag attgcccgtc
    10561 agatgggagc tgaacttacg gaaaaaggca acattaaagt taatgaaaat atggaaacaa
    10621 ccatcccggg actctatgcg gcaggtgact gtacaggtgg acttcttcag gtggcgaaag
    10681 ctgtatatga gggagcacag gcaggtatta atgcagggaa gtatgtaaga tctttaaaat
    10741 aaaagaataa gcaaaggaga tatgaatcat ggcaaaagag attacaacag caaattttga
    10801 aacagaagta ttaaaatctg agaaaccggt tcttatagat ttctgggcaa catggtgtgg
    10861 tccatgtatg cgtcagggtc cggttgtgga agaactggca gaagagggat acgcagtagg
    10921 aaaagtagac gtagatcaga atatggcact tgcacagcag tttcgtgtag tcagcattcc
    10981 gacactgatc ctgtttaaag acggtgcgga agtgaaacgc ttcgtaggtc ttacttccaa
    11041 agaagagctg aagagtgcac tggaaggcta aagatttatg aagattttat tagtggcatg
    11101 caatgcaaaa tatattcatt ctaatcttgc tgtttatgat ctgcaggcat atgcatctga
    11161 ttacgcagat catattgtat taaaggaata taccatcaac cagcagaaag atgatatcat
    11221 gcgtgatatt tatctggagc atcctgatgt ggtatgcgtg tcctgttata tctggaacct
    11281 ttcttttgta aaagaactga tggcagatct gataaagatt cttccgggcg ccgacttctg
    11341 ggccggcggt ccggaagttt cttatgatgc ggagaaattc ctgacagaaa actcagaatt
    11401 taaaggtgtt atggtcgggg aaggtgaaga aacatttaaa gaacttgccg gatattatgt
    11461 ggaaaaaaat ccgcaggatc tgaaagatat gacaggaatc tgttacagag acggagatca
    11521 gatcatacat aatggatggc gccagatcat ggacttaagc agtattccgt tcatttacaa
    11581 agatctgtct gagtttaaga acaggatcat ttattatgaa agcagcagag gatgtccttt
    11641 ctcctgcagt tactgtcttt cttccattga taagaaactg cgtttcagag atacagagac
    11701 agtaaagaaa gagctgcagt tttttataga caataaggtt ccgcaggtaa agtttgtaga
    11761 ccgtaccttt aactgtaaac atgaccatgc aatggcaatc tggaagtata ttaatgaaca
    11821 cgataatggt gtgacaaact tccattttga gatttcagca gatctgttaa gagaagagga
    11881 actgcaggaa atgtccacca tgcgcccggg tctgattcag ctggagatcg gagtacagtc
    11941 aacaaacccg gacacgatta aggcaattca cagaactatg gattttgaaa aactgaaagg
    12001 aattgttgac agaatccata gctttggaaa tatccatcag catctggatc tgattgcagg
    12061 acttccctat gaagattacg acagcttccg gcattccttt aatgatgttt atgcactgaa
    12121 accacagcag cttcagctgg gctttttgaa ggtgttaaag ggttcccata tgatggagat
    12181 gtgcagggaa tatggtattg tatacaaaac acaggagcct tatgaggtac tttccacgaa
    12241 gtggctggat tatgaccatg ttttgaagct gaaaactgtg gaaaatatgg tggaagtgta
    12301 ttataatagt ggacaattcc agaatacact tgaatatctg gaaaactttt tccaggatgc
    12361 tttctcgatt tatgagagac tgggcagctt ttacatggaa aagggctatg gtgatgtttc
    12421 tcatacaaga atgcgaagat atgagatcct gctggaattt cttgaggatg tgccggagat
    12481 ttccatggat caggtaaaag accagatggt atatgatctc tatctgagag aaaacctgaa
    12541 aagccgtcct ggctttgcca gagatcagaa gccttttgag agacaggtat gggacttcag
    12601 aaaacgggaa aaagtggcaa agaatgcaca tgtggaagta tttgcagatg gaacagtgct
    12661 gctgtttaac tatgcagacc gtgatccgct gactaacaac gctcatgtga cagatgtgac
    12721 gaaagatgtg tttgagaacc tgaacagaga ttaaagaggt gaagagaaat gggaatgttt
    12781 aatccaaaga accgtaaagt gatcacagca attattgcaa tcattctggt actggcaatg
    12841 gtagtgccga cagttctgtc tctgatcgta taataaattt tcggaggaaa agaatgagac
    12901 tgggacaggc ggcaatggag gctctgaggg cagaaataac cggatgcctg aaaccgggag
    12961 atgaactggt agtggcatgc ccggtggctt tgaaaggaac ctctgtaata gcaaaaaata
    13021 aaaaggacaa actggcagag agattctctg ccggttttat tcagaattgc gtttcacttt
    13081 gggatgctta tggagccggc agtattgtct ggaaaattgc gcaggaggca gatgccagcg
    13141 cattatatgc tatgggcgag ggcggttttt taagtgcgct ctggaagatg gcagaagctt
    13201 cagaagtagg actggaagca gacttccgta aggtaccgat tcgtcaggag actatagaag
    13261 tgtgcgagat ttttgacctg aatccatata agcttcaggc agatggagca gtattgattg
    13321 gaatccgcgg aggtgaagca ctggtacaga gacttcgcaa tgagggattt atggcagagg
    13381 tcatcggtca gacaaacagt ggcaatgacc ggcttctcta cagtggcggc agtgcccgat
    13441 atctggaacg tccggcagag gatgaactgc agcaactttt caaagagtaa ctgcaggaaa
    13501 cttaagagac aattttctaa gaaaagacag acgattaata acaagaggaa taaaaacaaa
    13561 atggcaaaat taaatattgt acttcatgag ccggagattc ctgcaaacac aggaaatatc
    13621 ggccgtacct gtgtggcaac aggaaccaga ctccatctta tcgagcctct gggattttcc
    13681 ttaagtgaga aagccttaaa gagagcagga atggattact ggaaagatct ggatgtaact
    13741 acatatctgg actttgagga ctttctggag aagaatcccg gggcaaaaat ttactatgca
    13801 acaacaaaag cacctcagac ttatactgat gttcattatg aagaagactg ctacattatg
    13861 tttggaaaag agagcgcagg aatcccggag gacattctgg tcaataatca ggaaacttgc
    13921 gtaaggatcc ctatgatcgg agatatccgt tctctgaacc tgagcaattc cgtagcaatc
    13981 gttctgtacg aggcactgcg ccagaataat tttgaccaca tgaatctgga aggacacctg
    14041 agaaactacg actggaaata atcacagtaa gcagactgga ggagttatat gccaaatacc
    14101 acaaaagcag ctctggaaga atccctgaaa cggcttcttc tgaagaaacc tctggacaag
    14161 atcacgataa cagatattac cacagactgt ggaataagcc gcatggcttt ttattatcat
    14221 ttcaaggata tttatgatct ggttgaatgg tcctgtgtgg aagatgggac aaaagccctt
    14281 cagggcaaaa agacttctga atcctggaca gaagggctga cccagatatt tgaggcagtg
    14341 ctggaaaaca aaccgtttat tatgaatgtt tacagaaatg tggacaggga gcggatagaa
    14401 aattatcttt ttaaattaac ctatgatctg atcgtgggtg tggtggaaga aaaaagcaag
    14461 ggtctgaata tcacagaaga ggataagaaa tttattgcag acttctataa atatggtttt
    14521 gtgggaatca tgcttgagtg gatcagggaa ggaatgaaag aaaatattga agatctggta
    14581 agaatgatgg atctgacgct tcacgataca gtgactacat ccattcataa ctttcagaaa
    14641 aataatatgg aaaaataatc atataaaaat tctttacaaa agccgcaggg tgataaaaaa
    14701 cttatcattc ggcggctttt gtaaattgta gaatcatatt ttaactgtta atatacagcc
    14761 atagcaacaa acaaatcatt cagacggatg aaatgcttat gatatgggaa acatacagat
    14821 aagaatgtaa aagtcatgaa gatgtcttga cgggagatca agagatttcc ggcaggcaaa
    14881 agagttgccg ggaaatgggt aaagcagaga gtaaaaagca ttcaggataa cgaatctgaa
    14941 agaacttcta aagaagaaat caagaaaggt ggatgtgtat tatgagtaaa aataaaggtt
    15001 tgggacttgt atccgcattg gcagttggag caggcgtggc agcagtggca gcaggaaaga
    15061 agtataaaac agctgagaca aagaaaaaag aagattatga tgcacttcat aatacaagtg
    15121 aatatcgcaa tacagaacgt ggaaaatatg agaaaaacag taagggaatt tattatacaa
    15181 acggtaacta tgaagcattt gcacgtccaa gaaagccgga aggcgtagat gataaacatg
    15241 cttatatcgt aggaagcgga ttggcttctc ttgcagcagc ctgtttcctt gtacgtgacg
    15301 gacagatgcc cggaaagaat atccacattc tggaagcaat ggatattgca ggcggagcat
    15361 gtgacggtat ctttgatccg agccgcggat atgtgatgcg tgggggacgt gagatggaaa
    15421 atcatttcga gtgcttatgg gatcttttca gaagtattcc atccattgaa acacctggtg
    15481 tatctgtact tgatgaatat tactggctga ataaggaaga ccccaactat tctctctgtc
    15541 gtgcaacaaa agagagaggc aaggatgctc atacagacgg taaattcaat ctgagccaga
    15601 agggctgcat ggagatcatg aagctgttca tgacaaagga tgaagatctt tatgacaaga
    15661 caattgaaga tgtatttgac gatgaagtat ttgattccac attctggtta tactggagaa
    15721 ccatgttcgc atttgagaac tggcacagtg cactggaaat gaaactgtac ttccagagat
    15781 ttatccatca catttccgga cttccggatt tcagcgccct gaaatttact aaatacaatc
    15841 agtatgaatc cctgattctg ccaatgcaga aatatctgga agaagcaggc gttgaattcc
    15901 agttcaatac agaggttaca aacgtactct ttgagtttga aggcaataag aagattgcaa
    15961 aagcaatcga gtgtaaggtg aatggcgtag aaaagggaat tgttcttaca gaaaacgact
    16021 ttgtatttgt gacaaacgga agctgtacag agggaaccat ctatggcgat cagaatcatg
    16081 caccgaacgg agatgcagaa gttcgtacaa gtggatgctg gagtctctgg aaaaatatcg
    16141 caaaacagga tccgtccttc ggacatcctg agaaattctg ttctgatatt gctaagacaa
    16201 attgggagtc agcaacagtg actactctgg atgataagat tattccttat attacagata
    16261 tctgcaaacg tgatccgaga acaggcaagg ttgttacagg cggtattgta agctgtcagg
    16321 attccagctg gttattaagc tggacgatca acagacaggg acagttcaag gatcaggaca
    16381 aagacaaggt ttgtgtatgg gtatatggtc tgtttacaga tgtacctggt gattatatca
    16441 agaagcctat gaaggagtgt acaggtaagg aaatcacaga agagtggctc tatcatcttg
    16501 gcgttccggt tgaccagatt gaagacatgg ctgagaacag tgcagtttgt gtaccgacca
    16561 tgatgcctta tattacagca ttctttatgc cgagaacaaa gggtgacaga cctgatgtta
    16621 ttccggatgg ctgtgtaaac ttcgcattcc tcggacagtt tgccgataca ccaagagata
    16681 ctgtatttac tactgaatat tccgtaagaa ct
//
