LOCUS       c00149_gnlPro..        12819 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JELDGKEC_149.
ACCESSION   c00149_gnlPro..
VERSION     c00149_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 03:00:56
            Original ID  :: gnl|Prokka|JELDGKEC_149
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12819
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..288)
                     /locus_tag="ctg149_1"
                     /transl_table=11
                     /translation="MRKEERYKGVLNWFKENVPVAETELHYDDPYQLLIAVILSAQCTD
                     KRVNMITPALFEAFPTPEVMAASTPEVVFEYIRSVSYPNNKAKHLVGMAKM"
     protocluster    1..12819
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8796:12817]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8797..12817
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..12819
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12819
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(457..2970)
                     /locus_tag="ctg149_2"
                     /transl_table=11
                     /translation="MKTLKYLLATMLLLGVCNLTHSQKLSLGIFPEPQEVTISSQTYAP
                     PHGYALRGINNPDADAVRLLKEALPFAKSGKSLPLEIKKLKDKAPEMQRSGAYTLTITK
                     KGITIGIVDDNSLFYAAQTLKQLVKYDEGKKILPLCSIKDYPDVLFRGTVEGFYGQPWS
                     HADRIEQIRFYGRIKLNTYIYGPKDDPYHSSPNWRKPYPAEEAEHIKELAKEAAHNKVN
                     FVWAIHPGQDIQWNQTDSMNILSKFEKMYDLGVRSFAVFFDDISGEGARPEKQAGLLNY
                     IHKEFIRKKSDVQPLIMCPTEYNRSWAKTDYLDILGTQLDPAIQIMWTGDRVVADITKE
                     GVEWVNNRIRRPAYIWWNFPVSDYCQDHLLMGPAYGLDTQAAGTMTGFVSNPMEYAEAS
                     KVAIFGVGMYTWNIENYDPTQAWKDACDFIMPEASMAFRIFCEHNCDPGPNGHQYRREE
                     SANYVAPIQTFLAGYKKNTFPEQSANLLGTLFAQITASPSMIYSQSPNKRLIEQINPWL
                     IQFEFLGKAGTSALHMAHAWYEKDRSYTWQRYLETSALLDSMKLINRTLNQKAQPKGVK
                     VGSKVLHPFIVDLYRQTGRNLLSTDGIAPDEVKVSIPSIFTNIDQLKSQPCAEGDNTVG
                     YVPLFEVVKVQPNQYLGIGWEIQKEAESFCFNLPKSNQPGRVFEWSADGKSWSLIPHVS
                     TENAKDTIRTIDPKARYIRMRNNSDQQMELYVLGFTATTKQDPQINEALMMYDMNLDTY
                     KNLNPGEMIHIKCDDINAVSFFLSGSNENLVSITGLSQDGEKNIVYQGNVGYIKLNKTM
                     FEDFSSLEITTIGKESIHIHQIVRE"
     CDS             complement(3072..4655)
                     /locus_tag="ctg149_3"
                     /transl_table=11
                     /translation="MIKITYKLILLLSLLAMTVTSFAASEAEYGKVSKAWTLHADGSQE
                     YRSSMELTLFTHTAMNSTYGESFIVYNPDFQTLKIHSSYTRQKDGTIVKTPDNAFVEVL
                     PRFAADAPAYNQLKEMVVVHTGLELGATIYLDYSIITKPGYYPALDINERLQETSPVKE
                     CKVSISVPEGTPLACGLYGSPVKAVEESHDGIKEVHWTLRNIPASSREAFQPKNREASP
                     HLVASTYPSGKAALATLDKRLKESQGYESKTFAQFLTDKSGNEQEKVNIIRDHILNNLS
                     TCPIPMAMTGYTVRDIDTVLRSAYGTPLEIAQLLNVMLNAAGIPSEVLAVYPGHLDTDA
                     CGLAAIQTLAVKATVDGKDQYLSASPLTNRGGLDKVVSLSGTSIEIETTPIQIKESRSV
                     AISADQAKDGFAICVLPAISAGIDSWGMSALNSKRSNLFELPSLIREEVTYTVTPAEGM
                     KLQTSTQEQVISKPFGKVTRTITPRGNTIEVVRTIELNKQQFTPAEYSDVRSLIHEWTN
                     PDNRVLLFSL"
     CDS             complement(4669..6576)
                     /locus_tag="ctg149_4"
                     /transl_table=11
                     /translation="MYGQDSCRYPQDPTLEKSQAYAGYDCVTLLDSTAVTVQPTGSGAF
                     AVCKAFKVQTPKGAVANRIIKYDYDPLTAHAEFRYATIYRANGDVINLDVTGACDYAAP
                     ARAIYWGARQIMLEVGRLQPGDVVEYEIAKKGFTYALLTAGDDERFIPPMRGQFYDIVP
                     FWATEPTVRKVYRVSMPMEKELQFQFYQGECTSSMRYEDGRKVYTFASDDILPFAKEPN
                     MVDLFDAAPKLMMSSTPRWEDKSVWFNKVNEDYGSFTAIPEAQRKVDELIKGKKTEMEK
                     IAVLTHWVADNIRYSGISMGKGEGFTLHNLKMNYTDRCGVCKDIAGTLIAFLRMAGFEA
                     YPAMTMAGSRVESIPADHFNHCVAVVKLASGTYMPLDPTWVPFCRELWSSAEQQQNYLP
                     GVPEGSDLCLTPVSAPENHYVRIHADNRLDEKGTLRGQFTITAEGQSDSNIRRIFTTGW
                     QSDWQNTMEKQLLAVSPNAKLLRVDYGKDPKNYQAAPIKITFSYEIPDYAIIAGDQMLI
                     KPLVMNNLYNQVKSFLRIDTKPENRAYGFKDACSRLVEQDETIRLPKGYTLLNAPKNDA
                     LRSNAADFEGSLSQEGDRNIVLRQKLALKKRVYDAADWKGFRSAVNAYKSYGDYLIIKK
                     "
     CDS             complement(6630..7697)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 52.4; E-value:
                     1.1e-16)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg149_5"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-17, bitscore:
                     52.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIQEDLQAFLAEWHDPSPFLEVQTSGSTGTPKRMRVRKDRMLNS
                     ARLTCDYLGLKKGDKALLCMPLRYIAGKMMVVRSLYAGLDLEVREPSGHPLADWGDTPL
                     RFAAMIPLQVYNTLRVPEERKRLEQTDILIIGGGAIDAALEQEIRQMPNTVYSTYGMTE
                     TLSHVALRRLNGPEASPYYHPFPSVTLSLSPDNTLVIDAPLVCDERLVTNDVARLLPDG
                     SFAIIGRKDNIINSGGIKIQIEEVEERLRPYLDLPYAITAAPDPRLGEAVVLLIAPRSC
                     ETVSPPRVTPHMKAIMSDSAQLSCEVSTVALASLPKYLRPRHVIEASEIPQTGSGKIDR
                     AACRELARNIITKTL"
     CDS             complement(7701..8759)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg149_6"
                     /sec_met_domain="MR_MLE_C (E-value: 1.4e-30, bitscore:
                     95.9, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKERFYKTEVVPRCLTFKRPAGTSRGVYTTRKLWEVRIRKEDEP
                     SVIGIGECAPLPDLSCDYGVDYEITLSKACLDLEQKGYVDTESLRHYPSILFGLEMAMR
                     HYEQGGWRHYDTPFSRGQAGIPINGLIWMGDYKYMLEQVEEKMKEGFRCVKLKIGAIDF
                     DRELSLLKHIRTHFSAKEIELRVDANGAFTPPEAMDKLKRLAEMDLHSIEQPIRAGQLE
                     EMAHLAAESPLPIALDEELIGCNAPDEKRRLLETIHPQYIILKPSLHGGISGCTEWIHL
                     AEAILGSTPEQPKWWVTSALESQIGLNAIAQWCATLGNPLPQGLGTGEIFKDDKHRLIQ
                     RKGDTIWFTNDL"
     CDS             complement(8797..9621)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg149_7"
                     /sec_met_domain="ECH_1 (E-value: 2.4e-82, bitscore: 265.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTTIKEYEEILFDFYNGIARITINRERYRNAFTPTTTTE
                     MSDAFYICRERPDINVVVLTGAGDTAFCAGGDMNVKGRGGYVGKDGVPRLNVLDVQKQI
                     RSLPKPVIAAVNGFAIGGGHVLHVVCDLTIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     IGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATMLYYMTDEAQEGGKAFLEKRRPRFEDYPKFP"
     CDS             complement(9625..11313)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg149_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.2e-08, bitscore:
                     21.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLIEHGVSNIVLCPGSRNSPIVHTLANHSFFN
                     CHSVTDERSAGFFAVGLALHGGKPAAVCCTSGTALLNIHPAVAEAFYQKVPLVVISADR
                     PAAWIGQMDGQTLPQPGVFGSLVKKSVQLPEIHTDQDEWYCNRLINEALLELNHHGKGP
                     VHINVPISEPLFQFTTPELPKVRVITRYQGLNVYDRKYDDLIERLNKYSKRMMIAGQMS
                     LIYLFEKKICKLLYKHFTWLSEHIGNRIVPGLPIKNFDAILYATPEEEKEKLVPELVIT
                     YGGHIVSKRLKEFLRKHPPKEHWHVSLDGEVADLFGSLTTVIEMDAFEFLEKIAYMLEN
                     RQIEYPKAWEYKSRNLPEPEFAYSEMAAIGGLIRSLPAESALHLGNSSTVRYAQLYTVP
                     ETVEVCCNRGTSGIEGSLSTAIGYASASQKLNFIVIGDLSFFYDMNALWNGNLHNNLRI
                     LLLNNGGGEIFQALPGFKMNERTHRYVTASHQTSAEGWATERGFSYSAVHNAEELAAAM
                     SAFTQTEQPSEHPLFMEVFTDKAEDVRLLKEYYHQLKNSSQAQNI"
     CDS             complement(11328..12425)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg149_9"
                     /sec_met_domain="Chorismate_bind (E-value: 1.2e-54,
                     bitscore: 175.0, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPRDSYEIIDTLIKQGRSFAIWRIPGEDRLHFRMQSAGSPCLLY
                     DIKDLNERSGFVIAPFQVTAERPIVLIQPDCFEIPSESDWDFSREKNEFPSNEIEIPSE
                     SEEKERYAYHFSLFTSPLLKGSQDKLVLSRSKTIRKDPSFSPGKAFFAAVERYIRSYVY
                     LCHTPETGTWMGGTPEILLSGEKGDWQTVALAGTQSLRDGKLPKSWDHKNWREQQLVAS
                     YIRRQLSTLGITPEEKGPYSARAGEVSHLKSDFFFSLPNPEKLGDVLQLLHPTPAVCGL
                     PKEEAYHFIIENEGYDRSYYSGFIGWLDPKGKTDLYVNLRCMNILPQTFTLYAGGGLLA
                     ASQLEDEWQETEDKLDTMRRIVGNL"
     CDS             complement(12422..12817)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg149_10"
                     /sec_met_domain="HBT (E-value: 1.3e-18, bitscore: 56.7,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="DQLNARAKHALMGNLGIQYTYASEDRVEATMPVDERTRQPFGILH
                     GGATLALAETVAGLGSMILAKPDEMVVGMQVSGSHMSSAHEGDTVRAVGTIIHKGRSSH
                     VWNVDIFTSTDKLVSSVRVINSILKKK"
ORIGIN
        1 cattttcgcc atacctacca gatgtttagc cttattgttc gggtaagata cgcttcgtat
       61 gtattcaaag acaacttccg gtgtgctagc cgccattacc tcgggagtcg ggaaagcctc
      121 gaacagggca ggtgtgatca tattcactcg cttatccgtg cattgtgcgg ataggattac
      181 cgctatcaat agttgatagg ggtcgtcata atgtagttca gtctcggcta ccggtacgtt
      241 ttccttaaac cagtttaata cgcctttata cctttcttct tttcgcattg ctttttcggt
      301 ttctgttttt cgcatcctaa aggtataact tttaatagga atatacaagc ggagatgtgc
      361 caaaaataag atacacccga attgtacgaa taaataaaaa agtaccgatc tccttcttcc
      421 atctaagaga gaaagaaatc ggtacttttt tatttattat tccctaacga tctggtggat
      481 atgtatagat tcttttccta ttgtggtgat ttctaaagaa gagaaatcct cgaacatggt
      541 tttatttaat ttgatgtagc ctacgtttcc ttgatagacg atgtttttct cgccatcttg
      601 ggagaggccg gtgatggata ccagattctc gttacttccg gagaggaaga aagatacggc
      661 gttgatatca tcacatttta tatgaatcat ttctcccggg ttcaagttct tatacgtatc
      721 taggttcata tcgtacatca taagagcctc attgatttgc gggtcttgtt tggttgtcgc
      781 cgtgaatcct agtacgtata gctccatttg ctgatccgag ttatttcgca tacggatata
      841 acgggctttc gggtcgatgg tgcggatcgt atctttagcg ttttccgtgg agacatgagg
      901 gattaggctc cagctctttc cgtcggcgga ccactcgaat acccgtccgg gttggttgct
      961 tttcggaaga ttgaaacaga aggattccgc ttctttctgg atttcccagc cgatacccag
     1021 atattggtta ggttgtacct tgactacctc gaatagggga acgtaaccga ccgtattgtc
     1081 accctcggca caaggctggc tctttaattg gtcgatattc gtgaatatgg aagggatgct
     1141 aaccttcacc tcgtccgggg cgataccgtc cgtagatagc aggttacgac ctgtctggcg
     1201 gtataagtct acgatgaaag ggtgtaagac tttcgatccg actttcacgc ctttaggctg
     1261 cgccttctgg ttcagcgtgc ggtttatcag tttcatgcta tctagcaaag cggatgtttc
     1321 cagatagcgt tgccacgtat aagaccggtc tttctcatac caagcgtgcg ccatatgcag
     1381 agcgcttgtt ccggcttttc ctaagaactc gaattggata agccatggat tgatttgctc
     1441 gatcaagcgt ttattgggac tttggctata gatcatactc ggggaagccg tgatttgagc
     1501 gaataaggtt cccagaagat tcgcgctttg ctccgggaac gtgtttttct tatatccggc
     1561 gaggaatgtc tggataggag ccacatagtt agcggactct tcccggcggt attgatgtcc
     1621 gttcggaccc ggatcgcagt tatgctcgca gaaaatgcgg aaagccatgg aggcctccgg
     1681 catgatgaag tcgcaagcgt ctttccatgc ctgtgtagga tcgtaattct cgatattcca
     1741 agtgtacatt ccaacgccga atatagcgac cttggaagcc tcggcgtatt ccataggatt
     1801 ggatacgaat ccggtcatgg tgccggcggc ttgcgtatct aggccgtagg cgggtcccat
     1861 caacaaatga tcttggcaat aatcgcttac ggggaagttc caccagatat aggcgggacg
     1921 acggatacgg ttgtttaccc actcgacacc ttctttcgtg atatcggcta cgacacggtc
     1981 tccggtccac atgatttgga tggcggggtc gagttgggta ccgaggatat ccagataatc
     2041 ggtcttagcc catgagcggt tgtattcggt agggcacatg atcaggggct gcacgtcgct
     2101 tttcttgcgg ataaactcct tatggatgta attcaataag ccggcttgct tttccgggcg
     2161 ggctccctct ccggatatat catcgaagaa gacggcgaaa gagcgtacgc ccaaatcgta
     2221 cattttctcg aatttggaaa ggatgttcat gctgtccgtc tggttccatt gaatatcttg
     2281 tcccgggtgg atggcccaaa cgaagtttac tttgttatgg gcggcctctt tcgctagttc
     2341 cttgatatgc tcggcttcct cggcgggata cggtttgcgc cagttggggg agctgtgata
     2401 aggatcatct ttcggaccat agatataggt gttcagcttg atccttccgt aaaagcggat
     2461 ttgctcgata cggtcggcgt ggctccaagg ctgtccgtag aagccttcca cggtaccccg
     2521 gaataatacg tccggatagt ccttgatcga gcagagaggc aggatcttct taccctcgtc
     2581 atacttgacc aattgcttga gggtttgggc ggcgtagaac aaggaattat cgtctacgat
     2641 cccgatcgtg ataccttttt tagtgatcgt cagcgtatag gcacccgagc gttgcatctc
     2701 cggggctttg tcttttagct tcttgatctc taaggggagg gatttgccgg atttagcgaa
     2761 aggtagcgct tctttaagta gtctgactgc gtctgcgtcc ggattattta tgcctcgtag
     2821 ggcgtatcca tggggcggcg cgtatgtctg gctggagata gttacctctt ggggctcggg
     2881 gaagattcct agggatagct tttggctatg cgttaggtta caaacgccta gaaggagcat
     2941 ggtggcgagt aaatacttta gtgtcttcat atacgatatg atttaatgtt aacgttcgta
     3001 aatgtatgaa ataattaaac acggagcaca cggaatacac agatttgttc cgtgccctcc
     3061 gtatttagat cttataggga gaatagcaat acccggttat ccggatttgt ccattcatgg
     3121 atcaagctac gcacgtcgct atattcggcg ggagtgaact gttgcttgtt caactctatc
     3181 gtacgtacca cctcgatcgt atttcctctt ggtgtgatcg tgcgggttac tttaccaaaa
     3241 ggcttgctta tcacttgctc ttgcgtggag gtctgcaact tcatgccctc ggcgggagta
     3301 accgtgtatg ttacctcttc cctgattagg gaggggagtt cgaataagtt ggaacgcttg
     3361 ctgttcaagg cactcatgcc ccagctatcg attccggcgg agatggctgg caatacgcag
     3421 atggcgaaac cgtcttttgc ttgatcggcg gagatggcca cggatctact ttccttaatc
     3481 tgaataggtg tggtctcaat ctcaatggaa gttccggaga gggagactac cttatctagt
     3541 ccgccacgat ttgtcagcgg ggaggcggat aggtattggt ctttcccatc gacagtggct
     3601 tttacggcta gtgtctggat ggcagccagc ccgcaagcgt ccgtatcgag atggccggga
     3661 tagacggcga ggacttccga cgggattccg gcggcattca acatcacgtt caagagctgt
     3721 gcgatctcta gcggcgtacc gtaagcactg cggagaacgg tatcgatgtc acggacggta
     3781 tagccggtca tcgccatggg gataggacag gtactgagat tgttgagtat atggtctcgg
     3841 atgatgttca ccttctcttg ttcgttaccg cttttatcgg tgaggaattg ggcgaaggtt
     3901 ttgctctcgt atccctgcga ttcctttaag cgcttatcca aagtggctaa ggccgcttta
     3961 cctgaaggat aggtagaggc taccaagtgg ggtgaagcct cacggttctt tggttggaaa
     4021 gcctcacggg aggaagcggg aatgttccgt agtgtccagt gtacctcctt tataccgtca
     4081 tggctctctt ccacggcttt tacgggggag ccgtatagac cgcaagccaa gggggtccct
     4141 tccggtacgg aaatagagac cttgcattcc ttcacgggag aggtctcttg tagtcgctcg
     4201 ttgatatcca gagccggata gtagcccggt tttgtgataa tagagtaatc caagtaaatc
     4261 gtggccccaa gttctaggcc agtgtgtacc acgaccattt ccttgagttg gttataggcc
     4321 ggagcgtcgg cggcgaaacg gggcaggacc tccacgaagg cgttatcggg tgtctttacg
     4381 atcgtaccgt ctttctgcct cgtataggat gagtgaatct tcagtgtttg gaaatcggga
     4441 ttgtagacga taaaactctc gccatacgtg ctattcattg cggtatgcgt gaagagcgtc
     4501 aactccatgg aggatcgata ttcttggctg ccgtcggcat gcaaggtcca agctttcgat
     4561 actttcccgt actcagcctc cgatgcggcg aatgaagtaa ccgtcatcgc taacaagctt
     4621 aggagaagaa tcagtttata ggttatctta atcattgtct ttcttttttt atttcttgat
     4681 aatcaaatag tcaccataac tcttataggc gttcacggcg gaacggaagc ctttccagtc
     4741 ggctgcgtcg tagacacgct tcttcaacgc tagcttctgg cgcaagacga tgttccggtc
     4801 gccttcctgt gaaagggaac cttcgaaatc ggccgcattg cttcgcaggg cgtcattctt
     4861 cggggcgttc aggagggtat agcctttggg gagacggatg gtctcatctt gttctaccaa
     4921 acgggagcaa gcgtccttga atccatacgc acggttttcc ggtttcgtat cgatacgcaa
     4981 gaaactcttc acttgattgt agaggttatt catgactagc ggcttgataa gcatctggtc
     5041 tccggcgatg atcgcataat cggggatctc ataagagaac gtgatcttga taggggccgc
     5101 ttgatagttc ttcgggtcct taccgtaatc tacacgaagc agtttggcgt tgggggatac
     5161 ggccagcaat tgcttctcca tcgtgttctg ccagtcggat tgccatccgg tggtgaagat
     5221 gcggcggata ttgctgtcgg actgtccctc ggcggtgatc gtgaattgtc cgcggagcgt
     5281 gcctttctcg tctaggcggt tgtcagcgtg gatgcggacg tagtggtttt ctggggcgga
     5341 gacaggggtc aggcagaggt cggagccttc gggcacaccc gggaggtagt tctgctgttg
     5401 ctcggcgcta ctccataatt ctcggcagaa aggaacccaa gtcgggtcga gaggcatata
     5461 cgtgccgcta gccagtttta ccaccgccac gcaatggttg aaatggtcgg cggggatgct
     5521 ttctacacgg cttcccgcca tggtcatcgc cgggtaagcc tcgaatccgg ccatgcggag
     5581 gaaggcgatc aacgtaccgg cgatatcctt gcagacaccg caacgatcgg tataattcat
     5641 ctttaggttg tgaagcgtga aaccctcgcc tttacccatc gagattccgg agtaacggat
     5701 gttatcggct acccagtggg tcaatacggc tatcttctcc atttccgtct tcttgccttt
     5761 gatcagctcg tctaccttcc tttgggcttc cgggatcgcg gtaaagcttc cgtaatcctc
     5821 gttaacctta ttgaaccata cggatttatc ttcccagcgg ggcgtgctgg acatcatgag
     5881 cttcggggca gcgtcgaata ggtctaccat attcggttcc ttggcgaaag gaaggatatc
     5941 gtcggaggcg aaggtatata ctttccgtcc atcctcatat cgcatggaag aggtacattc
     6001 gccttggtag aactggaatt gcaactcttt ctccatcggc atggataccc ggtatacctt
     6061 acgcacggta ggctcggtag cccagaaggg gacgatatcg taaaactgtc cccgcatagg
     6121 agggatgaaa cgctcgtcgt cgcccgccgt cagcaaggcg taggtgaaac ctttcttggc
     6181 gatctcgtac tccacgacat ctcccggttg caggcggccc acttccagca tgatctgccg
     6241 ggcgccccag tagatggcac gtgcgggggc ggcatagtcg caagccccag tcacgtcgag
     6301 attgatcacg tcgccattcg cacggtagat cgtggcgtaa cgaaactcgg catgcgccgt
     6361 cagcgggtcg taatcgtatt tgatgatacg gttggcgacg gctcccttgg gagtctgtac
     6421 cttaaaagcc ttgcatacgg cgaaagcccc cgagccggta ggttgtaccg tgacggcggt
     6481 gctgtccagc aaggtgacgc agtcgtatcc tgcgtaggct tgcgatttct ccaaggtagg
     6541 atcttgcggg tatcggcaag aatcctgccc gtacataggc gataaggcca atagggagac
     6601 cgcggtgatt gttagaatcc ttttcatgtt tatagtgttt ttgtgatgat atttctcgct
     6661 agctcccggc aggcggcacg atcgatcttg ccgcttccgg tttgggggat ctcgcttgcc
     6721 tctatgacgt gccttggacg gaggtacttg ggcaggctgg cgagagccac tgtcgatacc
     6781 tcacatgata gctgcgcgga gtcgctcatg atagctttca tgtgtggtgt cacccgaggg
     6841 ggtgataccg tttcacatga ccttggggcg attagtaaga ctaccgcctc tcccaaccga
     6901 gggtcggggg cggcggtgat ggcatagggg aggtctaggt agggccgtag ccgctcttcc
     6961 acctcctcga tctgtatttt gattcctccg ctattgatga tattatcttt ccttccgata
     7021 atggcgaaac tcccgtccgg cagcaggcgg gcgacatcgt tcgtcaccag ccgctcgtcg
     7081 caaaccaatg gggcgtctat caccaaggta ttgtccggcg acaaggataa cgtcaccgag
     7141 gggaagggat ggtaataggg cgaggcttcc ggcccgttca gccggcgcag ggcgacgtga
     7201 gacagcgtct ccgtcattcc gtaggtggaa taaaccgtgt ttggcatctg ccgtatctcc
     7261 tgttccaagg ccgcgtcgat cgccccgccg ccgataatca ggatatccgt ttgctccagc
     7321 cgtttacgtt cctcgggtac tcgcaacgta ttgtaaacct gcaaggggat catggcggca
     7381 aagcgcaggg gcgtatcccc ccaatccgcc aacgggtgtc cggagggttc acgcacctcc
     7441 agatccagtc cggcgtatag ggagcggacc accatcatct ttccggctat atagcgcagg
     7501 ggcatacata acagggcctt gtcgcccttc ttaagaccca gataatcgca ggtaagccgg
     7561 gcgctgttca gcatccggtc cttgcgcact ctcatccgct tgggcgtacc ggtggagccg
     7621 gaggtctgga cttccagaaa aggggaggga tcgtgccatt cagctaagaa tgcctgtaaa
     7681 tcttcttgta tcggcatagg tcaaaggtcg ttggtgaacc agatggtgtc tccttttcgt
     7741 tggatcaacc gatgtttatc atccttgaaa atctcgccgg ttcccagacc ttgcggtagc
     7801 gggttaccta acgtggcgca ccattgggcg atagcgttca gtccgatttg cgattccaga
     7861 gcggaggtga cccaccattt aggttgttca ggggtactcc ctaagatagc ttccgctaag
     7921 tgaatccatt ccgtacatcc ggagatacct ccgtggaggg aaggctttaa tataatgtat
     7981 tggggatgga tagtttccaa caaccgccgt ttctcgtccg gggcgttaca gccgatcagt
     8041 tcctcgtcga gagcgatggg aaggggtgac tctgccgcaa ggtgtgccat ttcttccaac
     8101 tgcccggcac ggataggctg ctcgatggaa tgtaagtcca tctcggcgag ccgcttcagt
     8161 ttatccatcg cctccggggg agtgaaagcg ccgttggcat ctacccgaag ctctatttcc
     8221 ttggcggaga aatgcgtgcg gatatgtttc aataaagaga gttcccggtc gaaatcgata
     8281 gcgccgatct tcagcttgac gcagcggaag ccctccttca tcttttcctc tacctgttcc
     8341 agcatgtact tataatcgcc catccagatc agtccgttaa tggggatgcc cgcttgcccc
     8401 cgcgagaagg gcgtgtcgta atgccgccaa ccaccctgtt cataatgacg catggccatt
     8461 tccaatccga aaaggatgga tgggtaatgg cgcaaagatt cggtgtcaac atatcccttc
     8521 tgttccagat cgaggcaagc cttggataac gtgatctcgt aatccactcc ataatcgcaa
     8581 ctgagatccg gcaggggggc acattctccg ataccaataa ccgagggttc gtcttccttg
     8641 cggattcgga cctcccacaa tttccgggtc gtgtaaacac cccgtgaggt tcctgccggt
     8701 cgcttgaaag tcaagcaccg gggaaccacc tctgttttat aaaacctctc cttcaccatt
     8761 cattctcaat tttcaattct caattctcaa ttccctttac gggaacttcg ggtaatcctc
     8821 gaagcgtgga cggcgtttct ccaagaatgc cttgccgcct tcctgcgcct cgtccgtcat
     8881 atagtaaagc atggtagcgt ctccggccaa ctcttgtata ccggcctgtc cgtccaactc
     8941 ggcgttcaag cccgccttga tcatgcgcaa ggccaacggg ctaagcaaca tcatctcctc
     9001 ggcccattga acgtactcgt cctctaattt atccaagggg actaccttat ttaccagacc
     9061 catatccaaa gcctcctgtg cattgtactt gcggcatagg aaccagatct cacgggcctt
     9121 tttttgtccg atcacacggg cgaggtaaga agagccgaac ccggcgtcga agctacccac
     9181 acgagggcct gtctgtccga agatagcgtt ctcggaagcg atcgtaaggt cacaaaccac
     9241 gtgcaatacg tgtccgccgc cgatagcgaa accgttcacg gctgcgatga cgggtttcgg
     9301 gagagagcgg atctgctttt gtacgtccaa tacgttcaag cgaggtacgc cgtctttacc
     9361 cacgtagccg ccacgtcctt tcacgttcat atcgcctccc gcgcaaaacg ccgtatctcc
     9421 ggctcctgtc agaacgacta cgttaatgtc cggacgttcc cggcagatgt aaaaggcgtc
     9481 gctcatctcc gtggtcgtag tcggggtaaa agcgttgcga taccgttccc ggtttatcgt
     9541 aatgcgggcg atgccgttgt agaaatcaaa taagatctcc tcgtattcct tgatggttgt
     9601 ccattctctt ttcgtttcca tatattatat gttttgtgct tgggatgaat tttttagttg
     9661 atgataatat tccttgagca atcgtacgtc ttccgctttg tccgtgaaaa cctccatgaa
     9721 taggggatgt tcgctcggtt gctccgtttg ggtaaaggcg ctcatcgcag ctgccaactc
     9781 ctcggcgtta tgaacggcgg agtaggagaa tcccctttcc gtggcccatc cctccgctga
     9841 ggtctggtgg gaggcggtga cgtaacggtg cgtacgctcg ttcatcttga atcccggcaa
     9901 ggcttggaag atctcgccac ctccgttgtt caagagcagg atgcgaaggt tattgtgcaa
     9961 gtttccgttc cacaatgcgt tcatatcata gaagaaacta agatcgccta taacgataaa
    10021 gtttagtttt tgcgaggccg aggcgtatcc gatggccgta gacaaagagc cttcgatccc
    10081 gctcgtacct cggttacaac aaacctcaac cgtctcgggt acggtgtaca attgcgcgta
    10141 acgtacggtg gagctattcc ccagatgcaa ggcagattca gccggaagcg aacgtatcaa
    10201 accaccgatc gccgccattt cggagtaagc gaactccggc tccggcagat tccgggattt
    10261 atattcccaa gccttcggat attcaatctg cctattctcc agcatataag cgattttctc
    10321 cagaaactcg aaagcgtcca tctcgatcac cgtggtcagg ctaccgaata aatccgctac
    10381 ctccccatcc aatgagacat gccaatgctc cttaggcggg tgtttccgca aaaactcttt
    10441 cagccgcttg gagacaatat ggccgccgta ggtgatcacg agctcgggaa ccagcttctc
    10501 tttttcctcc tctggggtag cgtacaggat ggcgtcgaaa ttcttgatcg gcaatcccgg
    10561 tacgatacgg ttgccgatgt gctcggagag ccaagtgaaa tgcttgtata gtaacttgca
    10621 tattttcttc tcgaagagat agatcaagct catttgtccc gctatcatca ttcgcttgct
    10681 atatttgttc aaacgctcga tcagatcgtc atatttccgg tcgtacacgt ttaggccttg
    10741 ataacgggtg attacccgta ccttcggcaa ttcgggtgtc gtgaactgaa ataaaggctc
    10801 ggagatcggg acgttgatat gaaccggccc tttgccgtga tggttcagtt ccaacaaagc
    10861 ctcgttgatc aatcgattac aataccattc atcttgatcc gtatgtattt ccggtagctg
    10921 taccgatttc ttcaccagcg agccgaacac cccgggttgc ggcaaggtct gtccgtccat
    10981 ttgcccgatc catgcggcgg ggcggtcggc ggatatcacg acaagcggaa ctttctgata
    11041 gaaagcctcc gctaccgccg gatgtatatt cagcaaggcc gtgcccgagg tacagcaaac
    11101 agccgccggc ttacctccgt gcaacgctag ccctacggca aagaatcccg cgcttcgctc
    11161 atccgtcacg gaatggcaat tgaagaacga atggtttgcc aatgtgtgca caatcggaga
    11221 gttccggctc cccggacata gcacgatatt acttacgccg tgctctatca gcaaggctac
    11281 caattgaagg atgttctttt tatcgctata cattatatga tataaaatta taaattaccc
    11341 actattctcc gcatcgtatc taatttatcc tctgtctcct gccactcatc ctctagctgc
    11401 gaggccgcca acagaccgcc tccggcatac agcgtaaagg tttgggggag gatattcatg
    11461 caacggaggt ttacgtacag atctgttttg cctttgggat ccagccaacc gatgaaaccg
    11521 gagtaatagc tacgatcgta cccctcattc tcgatgatga aatgataagc ctcctccttg
    11581 ggaagaccgc aaacggctgg agtagggtgt aatagttgaa ggacatcacc cagcttctcg
    11641 ggattcggca aggagaagaa gaaatcgctt ttcaaatggg aaacctctcc ggcccgggct
    11701 gaataaggcc ccttctcctc gggagtaata cccaaggtgg acagctggcg gcgtatatag
    11761 gaggcgacta attgctgttc tctccaattc ttatggtccc agcttttcgg taatttcccg
    11821 tctcgtaagg attgggttcc ggccaaagct accgtttgcc agtcgccttt ctcgccggat
    11881 aacaagattt ccggtgtccc acccatccaa gttccggttt ccggggtatg gcaaaggtag
    11941 acataggagc ggatatatcg ttctactgcg gcgaagaatg ccttgccggg tgagaaagag
    12001 ggatctttcc ggatcgtttt gctacgggat aggactagtt tatcttggct tccttttagc
    12061 aaagggctgg taaacaggga gaaatggtaa gcgtatcgtt ccttctcctc ggattcggat
    12121 gggatttcga tttcattcga agggaattcg tttttctctc gagagaaatc ccaatcggat
    12181 tcggagggga tttcaaagca atccggttgg attaaaacga taggtcgttc cgctgtcacc
    12241 tgaaacggag cgattacaaa accgctccgt tcatttaagt cttttatgtc gtataatagg
    12301 caaggagagc cggcgctttg catcctgaaa tggagcctat cctcaccggg aatacgccaa
    12361 atagcgaaac tccggccttg cttgatcaac gtgtctatta tttcgtaaga atctcttgga
    12421 atcatttctt ctttagtatg ctattgatta cccgtaccga ggaaaccagt ttgtcggtag
    12481 aggtgaatat gtctacgttc cacacatggg atgaacggcc tttgtggata atcgtcccga
    12541 cggcacgtac cgtgtctccc tcgtgggcgg acgacatatg gctgccgcta acttgcatgc
    12601 cgactaccat ctcgtccggt ttcgccagaa tcatggaacc tagtccggcc acggtctccg
    12661 ccaaagccag cgtagcgcct ccgtgcaaga taccgaaagg ctggcgggtc cgttcgtcta
    12721 caggcatggt cgcttccaca cgatcctccg acgcataggt atattgaatg cctagattac
    12781 ccattaaggc atgtttggcc cgtgcgttta gttgatcta
//
