LOCUS       c00368_gnlPro..        14487 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JELDGKEC_368.
ACCESSION   c00368_gnlPro..
VERSION     c00368_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 03:00:56
            Original ID  :: gnl|Prokka|JELDGKEC_368
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14487
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..369
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg368_1"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2.3e-23, bitscore:
                     73.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="SIEACLPYYEGVLGLKCYNIEVVADQKVKTAFFKVGQTKIELLEP
                     TSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDKAPRGGAEGLNIAFL
                     HPKSTCSVLTELCMPGNK"
     protocluster    1..14487
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4487]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..4487
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14487
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14487
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             406..1959
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg368_2"
                     /sec_met_domain="CT_Btheta (E-value: 1.6e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             1981..2868
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg368_3"
                     /sec_met_domain="OAD_gamma (E-value: 1.5e-12, bitscore:
                     38.4, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLFALLISFGAKAQRATSMRINEVLVINEDNFVDDY
                     GKRHGWIELFNTSAGTVNIAGCYLTDDKNNPMKYPIPKGDVLTQIQPRQHTLFWADGQP
                     GRGTFHVNFVLDPSKENYVALYDADGKTLIDEITIPAGQLADISYGRVIDGEKDWAQLK
                     KVTPSTNNLTLDSNEKIDNFRVNDSLGIGMTITAMAVVFLGLFLLYIIFKQIGKLSIAA
                     SKRNVEKAVGSASVTADAGQESGEIFAAIATALYEMSDDNHDIENTVLTIRKVQRAYSP
                     WSSKLYGLRQTPQK"
     CDS             2891..3322
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.8; E-value:
                     1.6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg368_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.9e-21, bitscore:
                     64.8, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIAELEVNGTPYQVKMEKPAKKQ
                     MVTLKRPAQAPTTASGDPVVSRPAASTTQGAVKTPLPGVILQVKCNVGDTVKRGQTLII
                     LEAMKMENNINADRDGKIIEIKVHKGDSVLEGADLVVIG"
     CDS             3327..4487
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg368_5"
                     /sec_met_domain="OAD_beta (E-value: 1.5e-153, bitscore:
                     501.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLTFLGENLQLFLTYTGVYNATPGHLIMILVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYTIALQMGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERLIRMKPPRAVSSTEKIIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKLFNLILKDGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             complement(4554..4700)
                     /locus_tag="ctg368_6"
                     /transl_table=11
                     /translation="MRKKSVNTLLVFGVVVAIILLMIWLFLGTTLVEDTSTEISPVPIE
                     QAN"
     CDS             complement(4769..5485)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg368_7"
                     /sec_met_domain="Peptidase_M22 (E-value: 1.3e-27, bitscore:
                     87.5, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLILNIETSTSVCSVALSEGEEVVFEKASFEGPSHAALLGVYME
                     EALEVAKSKGMKLDAVAVSSGPGSYTGLRIGVSVAKGLCFGYGIPLIGIHTLDILASAA
                     IRKNKEEADCLYCAMLDARRMEVYSSIYDSHLNTIRATTADIVDADSYASFLENGKVCF
                     FGDGAAKCETVITSPNACFIDGIYPLAVNMASLSQKAYDDARFENVAYFEPFYLKEFQA
                     TIAKNKVLNEALGKNK"
     CDS             5687..6547
                     /locus_tag="ctg368_8"
                     /transl_table=11
                     /translation="MTGFGKVTAELPSKKVTVEIKALNSKQLDLSTRIPSIYKDKEMEL
                     RSLLLQSLERGKVEFNIFIEYIGKDTPTQINLAAVENYYNQIKEIAEKLNISVPNDWFQ
                     TLLRMPDAIKSETVEPDESEWGVVLETVKDAIKHLCDFRIQEGAMLQKLFEQKIANIAT
                     LLKEVEKYEGERIEKIKARIMDNLQKIAEKDYDKNRFEQEMIYYIEKLDVNEEKNRLDN
                     HLKYFISTMESGHGQGKKLGFIAQEMGREINTLGSKSNHAEMQKIVVQMKDELEQIKEQ
                     VLNVL"
     CDS             6562..7128
                     /locus_tag="ctg368_9"
                     /transl_table=11
                     /translation="MAGKLIIFSAPSGSGKSTIINYLLKQDLHLRFSISATSRAPRGTE
                     KNGVEYYFLTPEEFRSRIANGDFLEYEEVYTDKYYGTLKSEVERILNEGDNVIFDVDVV
                     GGCNIKKFYGDRALSVFIQPPCIDDLRKRLEGRGTDSPEVIESRIAKAEYELGFTGQFD
                     KVVVNDDLETAQKDALKIIREFLNK"
     CDS             7132..7311
                     /locus_tag="ctg368_10"
                     /transl_table=11
                     /translation="MPNIFKNTRFMMGLSIVCGIASLVLGGISLYYKEYIIGGALIFNI
                     FICFINYKGWQKKG"
     CDS             7323..7898
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg368_11"
                     /sec_met_domain="CTP_transf_like (E-value: 5.9e-26,
                     bitscore: 81.7, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLKTGIYSGSFNPIHIGHLALANWLCEFEGLDEVWFVVTPHNPL
                     KKKDDLLDDSLRLEMAQAAIDGYPKFKVCDIEFHLPKPSYSIDTLRALSSNYPDRDFYF
                     IMGADNWLLFPRWKEYEKILQNYKLLIYPRLGFDISIPTIYPNVKKVDAPLMEISSTFI
                     RNAYQTGKDIRFFLPEGVRPYFGSVANQ"
     CDS             8747..9862
                     /locus_tag="ctg368_12"
                     /transl_table=11
                     /translation="MIYLLFLVTLLLISCNPDQAKDNGKDETIEYFIPLSHRVEKDVDE
                     MFEEYRYVPLETRDDALIDVLYNVKNIAIFQEDIYIGSGEQLIVWDKYGKFKRVLSKKG
                     NDPQSYLHFNHFMIWPNGDLSIASPIEIVTYSNSHQFINKKRCENVGYIEAITLLNDSL
                     YIIKCMPTPEQLRYRIINHHTGAIINSYDSIINCNRYISSFTNSFERYEGHIISHGYQS
                     NDILECTLDSSKIRYKINVDNRIPPAGFYTQEGKEGMQLIQEEAEKGYIGHIPDYVESK
                     ETILLSFKGKREDLNGIALIDKKDGNARVLENIKFDDNFRWLPKQFFSLDEGWCAMLMY
                     PEDVLKKEEFARRFPGLDEESNPVLFIGKLR"
     CDS             9882..11429
                     /locus_tag="ctg368_13"
                     /transl_table=11
                     /translation="MEHDNLFIQILEILSIKHTEDFTIRYYERHPHKNNLFGLSEMLRY
                     YNIENVAAEIQKTQENLSSLDVPFVAYVDHEFVSVRHVSTEAIIYSWRGKNITLSIPVF
                     LERWSGIVLLFESTDESIEPDYKEHRKEYLRQRIVIACFVSLLLSLIGCALITNRGMEI
                     GIWGLWGVNVIGASFCGILLSREILGSDKYVNKICSLFLKSSDCNGTLDSQASHFLGIS
                     WSVFGLGYFLSAILFIALLPQYVIYAETLNIIALPYTAWSVWYQKFRVKQWCALCLSVQ
                     ATVWITFLISLFAIGMDFNQWDLFDFTTIGCVYGLVILSLHFTVTLYVKEKQIQRSNNK
                     LSSIKLNASVFKSLLNEQPQYDIDKNTGILLGNRDAKEWITIISNPHCAPCAKLHLQIE
                     KLLKEYKEEICIQIILTSFSKELEPSAMLLTSMYLLNNESDYLRFLSDWYAKGRHKKED
                     CYKRYRLNPNDKDMLANFQAQNEWVRRNTISSTPTVLTNGYLLPEEYELKDISYLIN"
     CDS             11435..12478
                     /locus_tag="ctg368_14"
                     /transl_table=11
                     /translation="MNKLASQIDSLNKHLIGSLHTSYPFGLAHGKMGLLIYLYHLYDYT
                     QEAIYKEKAERLLDDLLENDLSKNAELTVEEGLCGVALGLDYIVKKQFVDGDINDLLSG
                     IDDLLFKKLVFGNMESRYSLSQLIHFLYYIYKRLEIQTNDNERFPFEGLAIKLVNQLAD
                     LIDASFFEESYTFSIYQYHVPILMKTLSYLIQYDFYKDRIQKVLEQLSLYMFSHLPHLH
                     LNRLYLLWGILPLRNCSPDWQRYVNELRKSINLDIIYNREIKGKDIYISNGYASLYFLL
                     EGLKRDFPEYTIPFNPHLIYDRIISSDAWDALMENEYYYNIHRGLLNGFPGTVLALLNI
                     KQRYLCE"
     CDS             12469..13158
                     /locus_tag="ctg368_15"
                     /transl_table=11
                     /translation="MRIDLTDTTFIIPVRIDSMIRLENLLMSVDSIVRYFRTRILIMEA
                     SSYQNEIIPSLIKDDTVKYTFLVDKDPVFYKTKYLNILAKQVDTPLVCIWDADVILDHL
                     QILDAVKQLRTRTSDVAYPYDGNFLDTSDILREHYWLHRDLDFLKKHQAKMNSLYTVEG
                     VIGAVGGAVFAQTEKYLQAGMENEDFYGWGLEDGERHYRWLSFGYRIYRSEGCLFHLSH
                     PRDQNGM"
ORIGIN
        1 agtatcgagg cttgtttacc ctattatgaa ggcgttcttg gattaaaatg ctacaatatc
       61 gaagtagtag cagaccaaaa agtaaaaacc gcatttttca aggtaggaca gactaagatt
      121 gaactactag agccgaccag cgaagatagc acgatcgcga aatttatcga gaaaaaaggt
      181 gaaggtatcc accatatcgc attcgcggta cctgatgtac aggcagcttt gaacgaggct
      241 gaggaaaaag gcgttaaatt aatcgataaa gctcctcgtg gtggcgcgga aggcttgaac
      301 atcgctttcc ttcacccgaa atcaacttgc agcgtattga cagaactttg catgccgggc
      361 aacaaataat taatccgttc atttctaaca acaaatcaaa atacaatgag taaccagctt
      421 gaaaaagtaa aagagctcat cgcacttcgt gagcaagctc gcttgggtgg aggagagaaa
      481 agaatcgaat cacagcacaa aaaaggcaaa tataccgctc gtgagcgtat cgccatgttg
      541 cttgacgaag gtagtttcga ggaattcgac atgtttgttc aacaccgttg tacaaacttc
      601 ggtatcgaga aaactaaata tttaggcgat ggtatcgtaa caggttatgg tacgatcgac
      661 ggacgtttgg tatatatctt cgctcaagat ttcaccgtat tcggtggagc cttgtctgag
      721 gctttggcta tgaagatctg taaagtaatg gatcaagcca tgaagatggg cgctcccgtt
      781 atcggtttga acgactccgg cggagctcgt atccaagaag gtgtaaacgc cttggcagga
      841 tatgcggaga ttttccaacg taacatcttg gcatctggtg ttgttcccca gatttccggt
      901 atcttcggcc cttgcgccgg tggagccgtt tattctccgg ctttgacaga cttcaacatc
      961 atgacacgtg gtaccagcta catgttcttg acaggtccga aagtagtaaa aaccgtaaca
     1021 ggtgaggatg taacccaaga gcagttgggt ggagccagcg tacacactac aaaatcaggt
     1081 gtagcccatt tcgctgttga tacagaagag gatggtttgc aattgattcg taaattgctc
     1141 agtttcttac ctcagaacaa cttagaggaa acgccgttag ttgagtgtaa agacccgatc
     1201 gatcgtctgg atgatgtatt gaacgatatc attcccgata acgctaacca atcttacgat
     1261 atgtatgagg ttatcggtac gatcgtcgat aacaacgagt tcctagaggt ccatgcggac
     1321 tacgctaaga atatcatcgt aggtttcgct cgtttcaacg gacaatctgt cggtatcgta
     1381 gccaaccagc cgaaggttat ggcaggatgc ttggatagca acgcatctcg taaagcaggt
     1441 cgcttcgttc gtttctgcga cgctttcaat attcctttgg taacattggt tgacgttccg
     1501 ggattccttc cgggtacagg tcaggaatac aacggtgtaa tccttcatgg cgctaaattg
     1561 ctttacgctt atggtgaggc taccgttcct aagattaccg ttacattgcg taagtcttac
     1621 ggtggagctt attgcgtgat gagttctaaa catttacgtg gtgatatgaa ttacgcatgg
     1681 ccgacagccg agatcgccgt tatgggcccg agcggtgccg tagaggttat cttcgccaag
     1741 gaagtagcag ccgctgaaga tccgaaagca tgcgcagcag agaaagaagc tgaatataag
     1801 aaagcattcg ctaatcctta taacgcagct caatacggtt atatcgacga tgttatcgaa
     1861 ccgcgtaaca ctcgtttccg tataattcgt gctttgcagc aattgcagac taagaagcta
     1921 agcaatcctg ctaagaaaca tgataacctg cctctataat ccgtaaaaca ggagatgaat
     1981 atgataaata agaaaatagg ggtattgcta ttgttcgctt tgctcatttc attcggggca
     2041 aaggcacagc gcgcaacctc catgcgaatt aatgaagtat tggttatcaa cgaggataac
     2101 ttcgttgatg actatggcaa acgtcatggc tggattgagt tgttcaacac ttcggccgga
     2161 acggtaaata tcgcgggatg ctatttgaca gacgacaaaa acaatcccat gaaatatccg
     2221 atcccgaagg gagacgtatt aactcagatc caaccccgcc agcacacact attttgggct
     2281 gacggacagc cgggcagagg tacattccac gttaacttcg tattagatcc ctctaaggag
     2341 aattatgttg ccttatatga cgccgacggt aagaccttga tcgatgagat cacaattccg
     2401 gcaggccaat tagcagacat tagctacggt agagtgattg atggcgaaaa agactgggca
     2461 cagttaaaga aagtcactcc cagtacgaac aacttgacgt tggactccaa tgagaaaatc
     2521 gataacttca gggttaatga ctctttaggt atcggtatga ctatcacggc tatggctgtt
     2581 gtattcttag gtctgttctt gttgtacatc atctttaagc agattggtaa attatctatc
     2641 gccgctagca aacgtaacgt agagaaggcc gtaggttctg cttcagttac cgcagacgca
     2701 ggacaagaat ctggagagat attcgccgcc atcgctaccg ctctatacga aatgagcgat
     2761 gataatcacg atatcgagaa cacggttctc actatacgta aggtacaacg agcttattct
     2821 ccttggagtt caaaactcta tggcttacgt caaactcctc aaaagtaatt atctaaaaac
     2881 gaactaaaga atgaaaagtt ttaaatatac cattaacggt aacgtatata aagtacacat
     2941 caattctgta gtggatgata tcgcagaact tgaagtaaac ggaactccct accaagttaa
     3001 gatggagaaa ccggcaaaga aacaaatggt tacattgaaa cgcccagctc aagccccgac
     3061 tacggcaagt ggagaccctg ttgtttcccg tccggcggct tctacgacac aaggggctgt
     3121 taagactccg ctaccaggtg ttatcttgca ggttaagtgc aacgtaggtg ataccgtgaa
     3181 gagaggtcaa accttgatta tccttgaggc tatgaagatg gagaacaaca tcaacgcaga
     3241 ccgtgacggt aagattatag aaattaaagt acacaaggga gactctgtgc tagaaggtgc
     3301 tgatctcgta gtaatcggat aagactatgc aagagagctt tttaacattc ttaggtgaga
     3361 acttacaact gttccttacc tatacaggtg tatacaacgc tactccggga catctcatca
     3421 tgattctggt aggtctgttg tttatattcc tggcgattaa atatgagttt gaaccgatgc
     3481 ttttgatccc tatcggattc ggtatcttga tcggtaatat ccctttcaag gacgcaggtc
     3541 ttcaagtagg tatttatgag caagggtctg tactgaacat cctctatcag ggtgtgacct
     3601 ctggatggta tccgccattg atcttcctcg gcatcggggc catgaccgac ttctccgcat
     3661 tgatctccaa tccaaagttg atgttgatcg gtgcagcggc tcagttcggt atctttggtg
     3721 cttatacgat tgctcttcaa atgggatttg agccgaacca agcaggtgct atcggtatta
     3781 tcggtggtgc tgacggtccg acggctatct tcctttcttc taagttagcg ccaaacttaa
     3841 tgggtgcgat cgcggtatcc gcctactcat acatggcgtt ggttcctatt atccaaccac
     3901 cgttcatgag attgcttacg actaagaaag agcgtttgat ccgtatgaaa ccgccgagag
     3961 ccgtttcttc cacggaaaaa attatcttcc cgatcgttgg cttgttgctt acttgcttct
     4021 tggttccgtc cggtttacca ttgttaggta tgctattctt cggaaactta ttgaaagaaa
     4081 gtggcgtgac tcgtcgtttg gcagaaactg ctcgtggtcc tctgatcgat acaatcacga
     4141 tcttattggg tatcacggta ggtgcttcta ctcaagcaac tcagttcttg acattgaact
     4201 ctatcaagat cttcggtcta ggtgcgttat cattcgtgat cgctacttgc gccggtgtat
     4261 tgttcgttaa attattcaat ttaatattga aagacggcaa taagatcaat ccgcttatcg
     4321 gtaacgccgg tgtatctgct gttcccgact cagctcgtat ctctcaagtc gtaggtttgg
     4381 aatacgaccc gaccaattac ttgttgatgc acgctatggg tccgaacgta gcaggtgtaa
     4441 tcggttccgc tgtagctgcc ggtatcttgc taggattcct tggttaataa aacaactatc
     4501 tatattaaaa aaggcgaggt ccgaaaggat cccgcctttt tatgttattg ttctcagtta
     4561 gcttgctcta taggaaccgg actaatctcc gtactcgtat cctccaccaa cgttgtcccg
     4621 aggaacaacc agatcatcaa aaggattata gcgacaacca caccaaacac caatagcgta
     4681 ttcacacttt tctttctcat gtctttaact gatttattca ttttagaata aacagccgga
     4741 acatgaattt ggttgtgtac ccttactctt atttgttttt ccctaacgcc tcgttcagca
     4801 ctttgttctt agcgatcgtt gcttggaatt ctttcaaata gaaaggctca aaataagcca
     4861 cattctcaaa acgggcatca tcatatgctt tctgcgacaa ggatgccata tttacagcta
     4921 atggatagat accatctata aaacaggcat tcggggaagt gattaccgtc tcacatttag
     4981 cggcaccgtc tccaaagaaa caaaccttac cgttctctaa aaaagaagca tacgaatcag
     5041 catctacgat atcagcagtc gtagcacgta tcgtgttgag atgggaatca taaatcgaag
     5101 agtagacttc catacgacgg gcatccaaca tagcgcaata caagcaatcg gcctcctcct
     5161 tatttttccg gatagcggca gacgctaaaa tatccagcgt atgaataccg atcaaaggaa
     5221 taccgtaccc aaagcataat cctttagcca cagacacccc gatgcgtaac cccgtataag
     5281 atccgggtcc gctacttacc gccacggcat ccagtttcat ccctttcgac ttcgcaacct
     5341 ctaatgcctc ttccatataa acgcccaata acgccgcatg agacggcccc tcgaaggaag
     5401 ccttctcaaa gaccacctcc tccccttccg acagggctac tgaacatacg gaagtggatg
     5461 tctcgatatt taagatcaat gacataataa ttaactatta acaattgata attgaacgaa
     5521 caaacaatct caatccttca atctgattag gctgcgaagg tatacaaaaa ttcattatac
     5581 tatcaaggca gccctatgag aaacatctat ttatgagaaa ataaacatca aatctaaaag
     5641 gaaaccacta tctttgcgca aacttttgag aaaaatgata caatcaatga ctgggttcgg
     5701 taaggttact gccgagctcc cttcaaaaaa agtaaccgta gagataaagg ctttaaacag
     5761 taagcaattg gatttgtcca cccgtatccc ttctatatac aaggataagg aaatggagct
     5821 tcggagcctg ttacttcaat ctttggagcg gggaaaagtt gagttcaata tctttataga
     5881 atatataggc aaagatactc ctacacagat caatcttgcc gccgtagaga attattacaa
     5941 ccaaatcaag gagatcgcag agaaactgaa tatcagcgtt ccgaacgatt ggttccagac
     6001 cttgctccgg atgccggacg caatcaagtc cgagaccgta gaaccggacg aatccgaatg
     6061 gggggtggtt ttagaaacgg taaaggacgc tatcaagcac ctgtgtgatt tccgtatcca
     6121 agaaggagcc atgcttcaaa agctttttga gcaaaagata gccaatatcg ccactctgtt
     6181 gaaagaagtg gagaaatacg agggggaacg tatcgagaaa atcaaagctc gtatcatgga
     6241 taacctgcaa aagatagccg agaaggacta tgacaagaat cgtttcgaac aagaaatgat
     6301 ctattacatc gagaagctgg atgtcaacga ggaaaagaac cgtttggaca accacttgaa
     6361 atattttatc tcaaccatgg aatccggtca cggccaaggc aagaagctcg gttttatcgc
     6421 tcaggaaatg gggcgtgaga tcaatacgct cggatcaaag agcaaccacg ccgagatgca
     6481 gaagatcgtg gtccagatga aagacgagtt ggaacaaatc aaggaacagg tactaaacgt
     6541 attataataa gattaacgag aatggctggc aaattaatta tcttctccgc accctcgggt
     6601 tccggaaaat caaccattat taattatctt ttgaaacaag atttacacct tcgtttctcc
     6661 atctcggcta ccagccgggc tccgcgggga accgagaaga atggtgtgga atattatttc
     6721 cttacgccgg aagagttccg cagtcgtatc gctaatggag acttcttgga atatgaggag
     6781 gtgtataccg ataaatatta cggtacgtta aagagcgagg tagagcgtat cttgaatgaa
     6841 ggggacaacg tgattttcga tgtggatgtg gtaggcggat gcaatatcaa gaaattctat
     6901 ggagaccgtg ccctgtctgt ctttatccaa cctccttgca tcgatgacct acggaagcga
     6961 ttggaaggac ggggaacaga cagcccggaa gttatcgaaa gccgtatcgc caaggcagag
     7021 tatgaattag ggttcacggg acagtttgat aaggttgtcg taaacgatga tctggagact
     7081 gcccaaaaag atgcgttgaa gatcattcgt gagttcttaa acaaatagtc tatgcctaat
     7141 atattcaaga atacccgttt tatgatgggg ctttctatcg tttgtgggat agcgagcctc
     7201 gtattaggtg gtatcagcct gtattataag gagtatatca tcgggggtgc cctgatattt
     7261 aatatattca tttgttttat caactataag ggttggcaaa agaaggggta agtataaatc
     7321 ggatgagact caagaccggc atctacagtg gatcgttcaa tcccattcac ataggccatc
     7381 tcgccttggc gaactggcta tgtgagttcg agggactgga tgaggtgtgg ttcgtggtca
     7441 cgcctcataa tccgctgaag aaaaaggatg acttgctaga tgactcacta cggttggaaa
     7501 tggcccaagc cgccattgac ggatatccga aattcaaggt ctgcgatatt gagttccacc
     7561 tgccgaaacc ttcttattcc attgataccc tacgagcctt atccagtaac tatccggata
     7621 gggactttta ttttatcatg ggagccgata actggctgct ttttccccga tggaaagaat
     7681 atgaaaaaat actccaaaac tacaaactgc tgatttatcc ccgcctagga ttcgatatct
     7741 cgatcccaac catttatccg aacgtgaaaa aggtagacgc tcccttgatg gaaatctcct
     7801 ccacatttat ccgtaacgct taccaaaccg gcaaggatat ccgtttcttc ctaccggaag
     7861 gagtgcggcc ttatttcggg tcagtagcaa atcagtgaca tacctgcgat agaagatata
     7921 cttacttggg ctatgaagta tatatcctat gccacttgaa gtatatattc ttcgagaagg
     7981 gaagttatac cgtgattatt tacagctttg ccatcttagg gcaatctgcc aaaattccca
     8041 ttaaaacatg ttttacagca cagccgttaa agatgatccc cgtaacatca aaacaggctc
     8101 acccgataat ctttttggag tatccaaata tataatttga gccttgtcaa gtgattagtt
     8161 attcatttgg gaggctttgt acctatagct tacgctatta cataaaacac tattacataa
     8221 caaattacat caatacaata agtcatttct cgaacaaatt aaacgtggga cagaacaatc
     8281 gaattcgcat agctaactta tatgcatatc tccactaatt ttctactgta gcaatagaaa
     8341 gacaatatac attaaacaac aataaaaaag acataatata ccccatgttt gatatttttt
     8401 aattttcttt gtaatatcaa agtattacac atctattaac tttttaaatc tttcaaatta
     8461 tggacaaact caaaaaaact gacaaaagtc gtactaaacc aacaaagtaa agttcttcca
     8521 aaagaacaaa tgatgaaaat cttaggggga ggaagtgcgt attgtcattg tcataatctt
     8581 tcttcctcaa ttgaagtaac aagctgctct gaatgctgta ataaatgctc aaattatggc
     8641 ggcgtacaaa actgtaacac tacaggaggt tagcaacaaa agaaagggct ggttttagct
     8701 ggtgatatct gctaaaacca gcttttttct taaaacaaaa atgaccatga tctatcttct
     8761 atttttagtc actcttttgc ttatcagttg taatccggat caagccaagg ataatggcaa
     8821 ggacgaaaca atcgagtatt ttattccact ctcacatcgg gtagaaaaag acgtggatga
     8881 aatgtttgag gaatatcggt atgtcccctt ggaaacaagg gatgacgcat tgatagatgt
     8941 gctttacaat gttaaaaaca tcgctatctt tcaagaggat atttacatag gctccggaga
     9001 gcaattaatc gtttgggata aatatggaaa attcaaacga gtcttatcca aaaagggaaa
     9061 tgatccgcaa tcatacctcc actttaacca tttcatgata tggcccaatg gagatctatc
     9121 gatcgcttct cccattgaaa tcgtaaccta ttcaaattca caccaattca tcaacaaaaa
     9181 gcgttgcgag aatgtcggct atatagaggc gatcactctt ttgaacgata gtctatacat
     9241 cataaaatgt atgcctaccc ccgaacagct acgataccgt atcatcaacc atcatacggg
     9301 agccattata aactcgtatg attccatcat caactgcaat cgatatatca gttcattcac
     9361 aaactcattt gaacggtatg aaggacatat tatctctcat ggttatcaaa gcaacgacat
     9421 ccttgaatgc actttggata gttcaaaaat acgatacaaa ataaacgtag ataacaggat
     9481 accgcccgcc ggcttttaca cgcaagaggg aaaagaaggc atgcaactca tacaggaaga
     9541 agcggagaaa ggatacatcg gccatatccc ggactacgtg gagtccaagg aaacgatatt
     9601 gctctccttt aaggggaaaa gagaagacct aaacggaata gccttaatcg acaaaaaaga
     9661 cggaaacgca agagttttag agaacatcaa gttcgatgac aacttccggt ggttgcccaa
     9721 acagttcttc tcgttagatg agggctggtg cgccatgctg atgtatccgg aagacgtttt
     9781 gaagaaggaa gagttcgcaa ggcgtttccc cggactggac gaggagagta acccggtgtt
     9841 gttcattggt aaactaaggt aatcattaaa gacctaaagc aatggaacat gacaatctat
     9901 tcatccaaat tttagaaatc ttatcgataa agcacacgga agattttacc ataagatact
     9961 acgagaggca tccacacaaa aacaatctgt ttggactgtc cgagatgcta cgttattata
    10021 atatagagaa tgtagcggcc gaaattcaaa aaacacaaga aaacttatcc tcattggatg
    10081 taccctttgt ggcttacgta gatcatgagt ttgtatcggt gcgacatgtt tctaccgagg
    10141 caatcatcta ttcatggcga ggtaaaaaca tcacattatc tatcccggta ttcttggaac
    10201 gatggtcagg aatcgtcctt cttttcgaat ccaccgatga atctattgaa ccggattata
    10261 aagagcatag aaaggaatac ttacgacagc ggatagtaat cgcatgtttc gtttcattac
    10321 ttctatcatt aatagggtgt gcccttatca ccaacagagg aatggagata ggaatctggg
    10381 ggttatgggg tgttaatgtg atcggagcat ctttctgcgg tatcctgctt tctcgagaga
    10441 tcttaggctc ggataaatat gtcaacaaaa tttgttccct gtttttgaaa tccagtgatt
    10501 gcaacgggac attggattcc caagcatctc atttcttggg gatcagttgg agtgtcttcg
    10561 gcttaggata ttttctttcc gcaatattgt ttatcgcctt gttgccccaa tatgttatat
    10621 atgcagagac tctgaatata atcgcattac cttatacagc gtggagcgta tggtaccaaa
    10681 aatttagggt aaaacaatgg tgcgctttat gtttatctgt acaagctacc gtatggatca
    10741 cctttcttat ctctctattc gcgataggca tggatttcaa tcaatgggat ttatttgatt
    10801 tcactaccat tggatgcgtg tatgggctcg tcattctatc gctccatttt actgttacat
    10861 tatacgtaaa agaaaagcaa atccaacgaa gcaacaataa acttagcagc ataaaactga
    10921 atgcctctgt atttaagagc ttattaaacg aacagcctca atatgacatt gacaaaaata
    10981 caggaatatt attgggcaat agggatgcca aagagtggat taccattatc tctaatccac
    11041 attgtgctcc ttgcgcaaaa ttacatctcc aaatagaaaa gttactcaaa gaatataaag
    11101 aagagatttg catacaaatc atcttgacct cttttagcaa ggaattagaa cctagcgcca
    11161 tgctactgac ctccatgtat ctactaaata atgaatcgga ttatttacga ttcctatctg
    11221 actggtatgc aaaagggcgt cataaaaaag aggattgcta taaaagatac agattaaatc
    11281 ctaatgacaa agatatgtta gccaattttc aagcacaaaa cgaatgggtt aggcgcaata
    11341 caataagttc cactccaaca gttttgacaa atggttattt attgccggaa gaatatgagt
    11401 taaaggatat atcgtattta ataaattaag tactatgaat aaattagcat cacaaataga
    11461 ttcgctaaat aagcatttga taggctcatt acatacaagc taccctttcg ggttggctca
    11521 tggcaaaatg ggattactca tctatttata ccatttgtat gattatacgc aagaagctat
    11581 ttataaagag aaggctgagc gattgctgga cgatctcttg gaaaacgatc tctctaaaaa
    11641 cgcagaactc accgtggagg aaggtttatg cggagttgcg ttaggattgg attatattgt
    11701 aaaaaagcaa tttgtagacg gtgatattaa tgatttgcta agtggtatcg atgatttgct
    11761 attcaagaag ctggttttcg gaaatatgga atctaggtat tccctgtctc aactcatcca
    11821 tttcttatat tacatttata aaaggctgga aatccagaca aacgataatg agcgtttccc
    11881 tttcgagggc ttagcaatca agttagttaa tcaattggcc gatttgatag acgcctcctt
    11941 tttcgaggaa tcctatacgt tttccattta ccaatatcac gtaccgatat tgatgaaaac
    12001 cctgtcctat cttatacaat atgattttta caaggatcgg atacaaaagg ttttggaaca
    12061 actatctctg tatatgttct cccatttgcc tcatctgcat ttgaaccgac tatatctgtt
    12121 atggggcata ctacctttac ggaattgttc gccggattgg caaagatatg tgaacgaact
    12181 aagaaaatca atcaatctag acataatata taatagagag atcaaaggca aggatatcta
    12241 tatcagtaat ggatacgctt ctctatattt cttgttggag ggattaaaaa gggacttccc
    12301 cgaatacacc atccctttca atccgcacct aatttacgat cggatcatct cgtctgacgc
    12361 ttgggatgcc ctaatggaga acgaatacta ctataatata cacagaggat tgctgaatgg
    12421 tttccccggt acggtgttgg cattgttaaa cattaagcaa agatatttat gcgaatagac
    12481 ttgacagata caacatttat tattcctgta cggatcgatt ccatgatccg tttggagaac
    12541 ctgttgatgt ccgtggactc aatagtacgt tatttccgga cacgcatctt aattatggag
    12601 gcctcatcat accaaaatga gattatcccc tcgttaataa aagatgatac ggtgaagtac
    12661 actttcctcg tggataaaga tcctgtattc tacaagacca aatacttgaa tatcctcgca
    12721 aagcaggttg atactccact tgtttgtatt tgggacgcag atgtgatact ggaccacctt
    12781 caaatattgg atgcggtgaa acagcttaga actaggactt ctgatgtcgc ttatccatat
    12841 gatggtaatt ttttagatac gtcagatata ttgagggaac attattggct ccatcgtgac
    12901 ttagatttcc taaaaaaaca tcaagcaaag atgaactctt tgtacacagt agagggagtg
    12961 ataggcgcag tcgggggagc ggtcttcgcc caaacggaaa aatacctgca agcgggtatg
    13021 gagaatgagg atttctatgg ctggggcttg gaggacggag aaagacatta ccgttggttg
    13081 agttttggct accggattta tcggagtgag ggctgtttat tccatttgtc tcatccccgg
    13141 gatcaaaacg ggatgtaaag ataaaattat tgggtcttaa gttcattggc ctacaaacct
    13201 aagatacttc accaaggatc ctaagatact ttaccgatga acctaagata ctttatccat
    13261 gaactaacaa gatcggtgac ctcaaccttt taccacataa gtcagcataa atcagaaata
    13321 ttttgtactt ttgcgccgta ttatacaaaa taatagcata atgaatctat tagaactgag
    13381 tgaacaggaa ataataagac gtaatagcat ggagcagttg cgtcagatgg ggatagagcc
    13441 ttatcccgca gctgagtatg taacgaacgc attttccaaa gagataaaag agacattcaa
    13501 agatgacgct gagccacgcc cggtacgtat cgccggccgt atcatgagcc gtcgtatcat
    13561 gggaaaagcc tctttcatgg agttgcagga ttccgagggc agaatacagg tctatatctc
    13621 tcgtgacgat atttgtccgg acgagaataa agacacatac aatgtcgttt tcaagaaatt
    13681 actggatatc ggtgatttcg tcgggatcaa gggattcgtt ttccgtactc aaatgggaga
    13741 gatttccgtt catgcgcaag aattgacagt tctgtctaaa tcacttcgtc cgctaccggt
    13801 cgttaaatat aaggatggtg tcgcttacga cggttttaat gacccggagc ttcgttatcg
    13861 ccagcgttac gtggatttgg tagtaaacga gggtgtaaaa gatattttca tgaaacgtgc
    13921 ggctatcatc aagaccatgc gtaccgcctt ggatgaggcc ggatacacgg aggtagagac
    13981 tccgatcctg caatctatcg caggaggagc cagcgcacgt ccattcatca cgcatcacaa
    14041 ctctttggat atcgatctgt atttgcgtat cgctaccgag ttgtatttga aacgattgat
    14101 cgtcggtgga ttcgagggtg tatatgagat cggtaagaat ttccgtaacg agggtatgga
    14161 ccgtacgcac aacccggagt tcacttgtat ggaactttat gtccaataca aggactataa
    14221 ctggatgatg agcttcactg agaagctgtt ggagcgtatc tgtatcgccg tgaacggtac
    14281 gagcgagagc acgatcgacg gtaagacaat cagcttcaag gctcctttcc gccgtttgcc
    14341 gatcttggag gcgatcaagg aaaagacggg ttacgacttg gaaggtaaga gcgaggacga
    14401 gatccgtacg atctgcaagg aattgaagat ggagatcgac gatacgatgg gtaaaggtaa
    14461 attgatcgac gagatcttcg gggagtt
//
