LOCUS       c00039_gnlPro..        13438 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HDKGPPEL_74.
ACCESSION   c00039_gnlPro..
VERSION     c00039_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 11:24:12
            Original ID  :: gnl|Prokka|HDKGPPEL_74
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13438
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13438
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5777:8994]"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5778..8994
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
     cand_cluster    1..13438
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Amidinotransf and OTCace and OTCace_N
                     and AA_kinase)"
                     /kind="single"
                     /product="Arginine2_Hcarbonate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13438
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Arginine2_Hcarbonate"
                     /region_number="1"
                     /rules="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /tool="gutsmash"
     CDS             complement(275..1204)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PLDc_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PLDc"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg39_1"
                     /sec_met_domain="PLDc_2 (E-value: 5.5e-27, bitscore: 84.4,
                     seeds: 83, tool: rule-based-clusters)"
                     /sec_met_domain="PLDc (E-value: 1e-08, bitscore: 25.3,
                     seeds: 30, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYDTSGSRGTKPSFFDHLRELGGEAQPFISTSKKHWFTTPRLNYH
                     LHRKLVIIDHHIGYIGGFNIGDQYVNKSPKFGHWRDTHLRVIGQSPILMEVRFAMDWNT
                     SIRRTNLPKFELKELKPFTVNRKDINDNKNVAMQIVSSGPDNQHYGIRRGYEGIIAGAK
                     KYIYIQTPYLIPEESILEALIIAANSGIDVRIMVRCMPDHPFVYRATEYYAKYLVALGV
                     KVYKYNDGFIHAKTMVSGSNIFSVGSANQDFRSYTLNFEVNSFNYNPALTQELKKIFEK
                     DLDKCTLLINDLNFPLTKVGLYLENSII"
     CDS             complement(1272..1697)
                     /locus_tag="ctg39_2"
                     /transl_table=11
                     /translation="MDYQYVWTVFRSRRSVVATWAWMLVLTVLPSIGFILYLFFGRQLS
                     HDEIFAIQEEQKKVQRHYLAEQRDMLKEHDLLPEKERLPRVRMLSELNLNNDDAILTFD
                     NQVKVFISGPELFDQMITDIKNAKKSVSLEFYTFYSD"
     CDS             1893..2393
                     /locus_tag="ctg39_3"
                     /transl_table=11
                     /translation="MLRKQIISAAGIMLAVIGLGAATTQSVDAVVTNPVRQGKRLNLTR
                     NATVYNRHGVKVGHLRKGKLYKVRAIKVINGNTYVKIRKNRFVKEEAFLPYMKTTVKVV
                     NRIKKHSFVYDENGEKIPGKFLKRGAKVNYLGHKEINKKPFIKIADGEYVKALNVLTTV
                     TNH"
     CDS             complement(2461..4743)
                     /locus_tag="ctg39_4"
                     /transl_table=11
                     /translation="MSEKFHGLTQAEADKRLKEDGLNEVPEPEYNFFKEFLSKLWNLSA
                     WILEGALILECILGKWIQSLFVLLMLLFAAFNGASKKKQSRRVLNTISHKLTPKVAVER
                     DGKWIKIDSKQLVRGDLISLQRGDVLAADVKMVSGKIACDESSITGEFKPVKKNIDDTA
                     YAGTTVVEGDGLAIVTATGKDSRSGKTINLINNSAAPGHLQQLLTKIIYYLCLLDGVLT
                     LVIIIASFFKGGNFDTFINMLPFLAMMFIASIPVAMPSTFALSNSFEATRLSKEGVLTA
                     DLTGIQDAANLNLLLLDKTGTITENKTAVASWSDLSDLPDKDVLALAGSATDKRNAGII
                     DIAIDEYLKENNIPAMDVEHFTPFTSDTGYSMAEVDGHNVKLGSFKQLSLIDKNANEAV
                     EAVEGINFKAGRSVAVLIDDKLAGVFILQDKVRKDSRAALAELKKRGVRPIMLTGDNQR
                     TAAAVAEQVDLTGNVISIHDFDESTDIDELAGIADVLPEDKLKMVKFFQEKGYIVGMTG
                     DGVNDSPALKQAEVGIAVSNAADVAKRSSKMVLLDDGLSSIVKILDAGHRVYQRMTTWS
                     LTKLARTAELTMLLTFGYLFFNYIPMALNAMVIYTIMNNMVTMMIGTDRTHITYKPENW
                     NMARLAKIAFSLAAGWTVIGIAFVSYLNMHGWSHNSISTMVYVYLVLSAMLIVLITRTR
                     KYFWQDYPSKLVGIVQIADVALTFILALCGLAMAQISWQNLLITVVVALIAAIIIDLIY
                     QPVMKNR"
     CDS             4872..5726
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     76.4; E-value: 4e-24)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg39_5"
                     /sec_met_domain="LysR_substrate (E-value: 4e-30, bitscore:
                     94.8, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1e-24, bitscore: 76.4,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIKQLRYFLVVAEEKQITSAAKRLYIAQPPLSYQLKQLEKELGA
                     QLFKRTAHGIELTDAGQILQSYASEILSLSESVKNQVHKTVSGELGTIAIGMASSSTGL
                     IPMKSFQDLTKFYPEINFDIYEDNTFGIIDKLEKKTIDLGIVRTPYNRNGINAKTLTTE
                     RMMAVTVDPKFKDKTELRIKDLNEQPLIIYRRFEEIFNQTFAHHGIKPFYAVKCDDSRT
                     AITWAKRKMGIALVPESIASTYAPDDLIPIKHSNWITHLQLVWRKDQKVTPLMKRIIDS
                     LSR"
     CDS             5778..7007
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: Amidinotransf"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_6"
                     /sec_met_domain="Amidinotransf (E-value: 3.1e-106,
                     bitscore: 345.3, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLIHVYSEIGKLETVMLHRPGRELENLSPDILNRMLIDDIPYL
                     KIAQKEHDYFAHTLEKQGVHVVYLEDLLAQSLTNEDVRTKFVDQLLEESNIKKEDSLHQ
                     LLMDYLIAMPVNEMVKQIIAGIRKNEIQNVTPSLADLAEDPDYPFYLNPMPNVYFTRDQ
                     QAAIGNGMTINGMTFRARRRESLFMETVLKHHPDFKNANIPIWRDRYTHGRLEGGDELI
                     LNNHVLAIGISQRTSAAAITDLAHSLFGHSSYDTILAIKIPHNHAMMHLDTVFTMINYD
                     QFTVHPFILDKSGKIDIYVLEQDDHGEIKITPETNLIKVLKNYLHLSEIDLIPTGGGDA
                     IAAPREQWNDGSNTLAIAPGEVVTYDRNYVSNDLLRKHGILVHEIHSSELSRGRGGPRC
                     MSCPLVREDL"
     CDS             7019..8059
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_7"
                     /sec_met_domain="OTCace (E-value: 1.3e-51, bitscore: 164.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="OTCace_N (E-value: 1.4e-48, bitscore:
                     154.8, seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYLQNVFQGRSLLKCKDYTPAELNYLIDFALHLKELKKENIPHE
                     YLKGKNIALLFEKSSTRTRSAFVVACNDLGANPEYMGAGEIHLGKKESIEDTAKVLGSM
                     FDGIEYRGFAQKDVEDLAKYSGVPVWNGLTDKWHPTQMLADFMTIKEKFGHLKGLTLAY
                     VGDGRDNVADSLLVAGSMLGVNVHIVTPKPLFTHPDVQKIAEGFAKDSGSRNLITDDIE
                     QGVKGANIIYTDVWVSMGENDWSERIKLLKPYTVTMKMMHMTGTSDDQLIFMHCLPAFH
                     DRTTKVGEEIYKKYGLSEMEVTDEVFNSQYAWQFTEAENRLHSIKAIMAATLGNLFIPS
                     VDEGSK"
     CDS             8062..8994
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: AA_kinase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_8"
                     /sec_met_domain="AA_kinase (E-value: 2.7e-36, bitscore:
                     115.4, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIVVALGGNAIEAGDNSAAAQEKQVEKTMKVVAKMIENGDQVA
                     IVHGNGPQVGNLLLQQYKGSSKDNPAMPLDTVVAMTQGSIGYWMQKALDDQFKHTNYSH
                     QAVALITQTIVNANDPTFKNPTKPIGPFYTFNEMQKQKIYHPEYTYKQDAGRGYRQVVS
                     SPKPVKIINAPVIDTLLKSKFVPIAAGGGGIPVVVKDDSLQGVAGVIDKDFSAVKLAED
                     IQADELVILTTVDNAYVNYNQPDQAPIGKIKIDQLKKYLEAGQFAAGSMKPKIEAVIDF
                     VEKTGKTAIITSLRNASKLDDGVGTIVYN"
     CDS             9011..9547
                     /locus_tag="ctg39_9"
                     /transl_table=11
                     /translation="MNIFQEGNPQNIAQVLAGKDYRVALQQAIFKKYPDATLVDINLNI
                     PGPIKNNRYLIKLFDYGIKQLEEIWQNKGYDYKLLKALNNDAGCENFYVLRESSKVVKL
                     STILFEENNKIGRLFDADVLIKGKPALSRQELEYSSRRCYLCNRPAKECARSRRHSVEE
                     MQRYISSLYAKYVNN"
     CDS             9668..10834
                     /locus_tag="ctg39_10"
                     /transl_table=11
                     /translation="MKLKKNQDDLKQIASLIEYAFLKDSDLTTDSNFMTRYDHSAGYGY
                     FDQEKLTSYMMVNKFKAEIFGHHVPLAGIGYVASYPEYRGRGHISKLMKEILFDLHDQK
                     ILVANLAPFSENFYRHYGFSNSIYQKEYGFSGAALASFRLPRKGKIIRGKWNDLIVQNG
                     VIQLYERQLHTDDERNTIIREAWWWNRLDDYYHHREIAVYFDEAGRPMSYLIYRIIDNC
                     FMADELYSITPQGLLSILGFMVAHIGSIKEFCMTLPEKSLLAELFPEQNELDIQLHPYM
                     MSRIIDFQKILSCMRPLQEGTFNIEVNYDDQCPWNIGVWQLTNYDHQVKCERKEDELVD
                     FSGPITTWTQILLGRLTMESAIKLGLITDYRIKKLDFIKGKVSFYDYF"
     CDS             10850..11011
                     /locus_tag="ctg39_11"
                     /transl_table=11
                     /translation="MSKQKKVRLLKFLSVVVSGINVVISLLIMLNKYQIRKDKKQIADE
                     GHAPLDEN"
     CDS             11014..11619
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg39_12"
                     /sec_met_domain="LysR_substrate (E-value: 5.1e-18,
                     bitscore: 55.2, seeds: 361, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRIAYFNQLGRRQLDRIVDQFKQKNSDVEIELIGMGHDEAFD
                     KLAKNEVDLAISDLRDDQLDFKKEILGQEAVMAILQKGSYPSGVQMINKDDLADLTCFI
                     VAKPEEEAAELHLFKDIYQIRSPFIASNSVEEAALLVASGSGYFLMNEATASLISNDTL
                     QRLFLLSNGQQMWQKIAAFYTNEDAVIKDFILLVKKVY"
     CDS             11696..11818
                     /locus_tag="ctg39_13"
                     /transl_table=11
                     /translation="MLERKLLPLSAMVLALGLSGLTTHVKAADTPLMVMVTERL"
     CDS             11815..12240
                     /locus_tag="ctg39_14"
                     /transl_table=11
                     /translation="VTVHKKMQGTWYSYDSNAHSGRKITFTAHTVNGKINYTQDKSIIS
                     DYFNGNIQDQAGFDRATKNWMSGQTTKMKNNLFYEINPWISFENWSLYRVMPQKINGKK
                     HNVLLYSSRYDGGNYYRSKKLAKQMKNYKFKKVDYHL"
     CDS             12453..13016
                     /locus_tag="ctg39_15"
                     /transl_table=11
                     /translation="MLNAKNALFMQSGHEDQRKYKNYLIESYQNDDAYQKHESLSQVQQ
                     FERDLKDIVNSQVKVKLYPEFISTKPEKLAITHDNQYVVYLTEIGVQLGKGDEFANAVM
                     KEMKTAVEKEDGILAMIAGTIMNQPNEWFSLEVYKTEETYEEYHKTKHFKKYLEATKYV
                     VESKGLHLLKPDCIMDQGEIFYRP"
     CDS             13295..13438
                     /locus_tag="ctg39_16"
                     /transl_table=11
                     /translation="MNDFTKNMAQALFNQDKVNDFLRKEIQTAVNQLLEAELTAFLGYD
                     PYA"
ORIGIN
        1 ctgtctcgaa acacattact gaagatgtat gaaaggatcg accaaagtgg gattcctttg
       61 gacttgcgga gcccacatct acggagaagc tccataactt tgtagtcctt gaagaacttt
      121 tcaacagaac gggcaatttt aggttcgttt tcagtatcga atgatggtaa actagacata
      181 gcgcaagcct ttcgtttgat ttcgtttgat attgatgatg ttttgatcga cttaattata
      241 tcaagcgaac aaaggccttg tgctttttta ttggctaaat tattgaattt tcaaggtaca
      301 agcccacttt tgtaagtggg aagtttaagt cattaattaa aagggtacat ttatctaagt
      361 ccttctcaaa aattttcttt aattcttgag ttaaagcagg gttgtagttg aatgagttta
      421 cctcaaagtt taatgtatag cttcggaaat cttgattggc ggaaccaact gaaaaaatat
      481 tagaaccgct aaccatagtt tttgcatgaa taaaaccatc attatatttg tatactttaa
      541 cgccaagggc tactaaatac ttagcatagt attctgtagc acgataaaca aatggatgat
      601 cgggcatgca acgaaccata attcgaacat caataccgct gttagcagcg ataattaagg
      661 cttcaagaat tgattcttcg ggaattaaat aaggcgtttg aatataaatg tattttttag
      721 ctcctgcaat aattccctca tagcctcgtc tgatgccgta atgttgatta tcaggtcctg
      781 aggaaacaat ttgcatagcg acatttttat tatcattgat atcttttcga ttgacagtaa
      841 atggtttaag ttcctttaat tcaaatttag gtaaatttgt tcttctgatt gacgtgttcc
      901 agtccattgc aaaccggacc tccattagaa ttggtgattg cccaattaca cgtaaatggg
      961 tatcccgcca atgaccgaat tttggtgatt tattgacata ttgatctcca atattaaatc
     1021 cgccaatata gccaatatgg tggtcaataa taactaattt tctatgtaag tggtaattga
     1081 gtcgtggggt agtaaaccag tgcttttttg aagtggaaat aaatggttga gcttcgccgc
     1141 ccaattctct taaatggtca aaaaagcttg gcttagtgcc tcttgatcca gaggtatcat
     1201 acataaatta ctcttacctt agcaccatta gctgcagcct cttccaaggc ttttaaagca
     1261 cgatgcccta attagtcaga ataaaaagta taaaattcta agctgacaga ttttttggca
     1321 tttttgatat cagtaatcat ttggtcaaaa agttctggtc cagaaataaa tactttgacc
     1381 tgattatcga aagttaaaat cgcatcatcg ttgttaagat ttagttccga cagcattctt
     1441 actcgtggaa gacgctcttt ttcaggtaga agatcgtgct ctttaagcat gtcgcgttgc
     1501 tcagctaaat aatgtctttg tacctttttt tgctcttctt gaatagcaaa gatttcatca
     1561 tgtgaaagct gacgaccaaa gaaaagatat aggataaaac cgatactggg cagaacggtt
     1621 aatacaagca tccatgccca agttgcaaca acgctgcggc gacttctaaa gaccgtccat
     1681 acatattgat aatccataag acttcgatag tcctacggat tatatcccaa gttaaaatca
     1741 tgaataatta ctcccttgta agtagtgtta taaataattt tagcagaatt aagcaaatag
     1801 ttataaaaca gatgagtaaa aaatgcttcc aattcgataa tttttgataa aataagggat
     1861 ggagaatggt ataaacacta cgggggtgga ttatgttgag aaaacaaatt atttctgctg
     1921 caggtataat gttagcagtt attggattag gcgcagcaac tacacaaagc gttgatgcag
     1981 ttgttactaa tccagttaga caaggtaaga gattaaatct aactagaaat gctactgttt
     2041 ataatagaca tggtgttaaa gttggacatt taagaaaggg aaagctttac aaagtacgtg
     2101 ccataaaagt aattaatggt aatacttatg taaagattcg taaaaataga tttgttaagg
     2161 aagaagcctt cttgccatat atgaagacta ctgtaaaagt agttaataga atcaaaaagc
     2221 attcctttgt ttatgatgag aatggtgaaa aaatcccagg caaattttta aagcgtggtg
     2281 ctaaggttaa ctatttaggc cataaagaaa ttaataaaaa accatttatc aaaattgctg
     2341 atggtgaata tgttaaggct ttgaatgtct tgactacagt tactaatcat taatcaaaaa
     2401 aacactctga aaactacatt actacaatgt agttttcaga gtgtttttgt tttaagttaa
     2461 ttatctgttt ttcattactg gttgataaat caaatcaata ataattgctg caattaatgc
     2521 aaccacaacg gtaattaata agttttgcca actaatttga gccattgcta aaccgcataa
     2581 agctaaaata aaggttaatg cgacatcggc aatttgaaca atacctacaa gtttagatgg
     2641 gtaatcttgc cagaagtatt tacgagttct agtaattaat acaattaaca ttgcacttag
     2701 aactaagtaa acatagacca tggtagagat agaattgtga ctccagccat gcatgttgag
     2761 gtagctgaca aaagcgatac cgataactgt ccaacctgca gcaagagaga atgcgatttt
     2821 ggctaacctt gccatattcc aattttctgg tttgtaagta atatgggtac ggtccgtacc
     2881 aatcatcatg gtaaccatgt tattcatgat tgtgtaaata accatagcat ttaatgccat
     2941 tggaatatag ttgaagaaga gatagccgaa ggttaaaagc atagttaatt cggcggttct
     3001 ggcgagctta gtaagtgacc aagtagtcat tcgttgatat acacggtgac cagcatcaag
     3061 aattttaaca atagagctta agccatcatc tagaagcacc atcttacttg aacgcttggc
     3121 aacatcggca gcgttagaaa cagcaatacc aacttcagct tgctttaaag caggagagtc
     3181 gttaacacca tcaccagtca taccaacgat ataacctttt tcttggaaga atttaaccat
     3241 cttaagttta tcttcaggta aaacatcggc aatccctgct aattcatcaa tatcggtgct
     3301 ttcatcaaag tcatgaatag agataacgtt accagttaaa tcaacttgtt cagcgactgc
     3361 tgcggcagtt ctttgattat caccagttaa catgattgga cgtacgcccc gttttttaag
     3421 ttctgctaaa gcagccctag agtcctttct tactttatct tgtaaaataa atactcccgc
     3481 aagtttgtca tcaattaaca cggcaactga gcgtccagct ttaaaattga tgccttcaac
     3541 tgcttcaact gcttcatttg cattcttatc gattaatgaa agttgcttaa atgaacctaa
     3601 cttaacattg tgaccatcta cttcagccat agaatagcca gtgtcagaag taaatggggt
     3661 aaagtgttca acgtccatgg cagggatatt attttctttt aagtattcat caatggcgat
     3721 atcaatgata cctgcattgc gcttatcagt tgcactaccg gctaaagcaa gtacatcttt
     3781 atctggcaaa tcgcttaaat cgctccaact agcaactgca gttttgtttt cagtgattgt
     3841 tcccgtctta tcaagtaaaa gcaagtttaa gttagctgca tcttggatac cagttaaatc
     3901 agctgttaag acgccttctt tacttaaacg ggttgcttca aatgaattgg acaatgcaaa
     3961 ggttgacggc atcgcaaccg gaattgaagc gatgaacatc atggctaaga atggcaacat
     4021 gttgataaac gtatcaaaat taccaccctt aaagaatgaa gcaatgataa taactaaggt
     4081 aagtacaccg tcaagtaggc aaaggtagta aataatctta gttaaaagtt gttgcaagtg
     4141 accaggtgca gctgaattgt tgatcaagtt aatggtctta ccacttcttg aatctttacc
     4201 agttgcagta acaattgcta atccatcgcc ttcaacaaca gtagtaccag cataagctgt
     4261 gtcatcaatg ttctttttaa cgggcttgaa ttcaccggta attgagcttt catcacaggc
     4321 gatcttaccg ctaaccattt ttacatcggc tgcaagtaca tctccacgtt gaagtgagat
     4381 taagtcgcct ctaactaatt gcttagagtc aattttgatc cacttaccat cgcgttctac
     4441 agccacctta ggggttagct tatgtgaaat ggtatttaat acccgccgtg actgtttctt
     4501 cttggatgca ccgttaaaag ccgcaaaaag aagcatcaac aagacgaaca aagattgaat
     4561 ccatttgcct aagatacatt cgaggattaa ggcaccttct agaatccagg cagaaagatt
     4621 ccataatttt gatagaaatt ccttaaaaaa gttgtattcg ggttcaggta cttcgtttaa
     4681 cccatcttct ttaagtctct tatctgcttc ggcttgagtt aagccatgaa atttttcaga
     4741 cattttattc cctccaaatc taccttaata aagtagcaca tatgttgttt gaatgaaaat
     4801 actaaattaa aatataagat atagaaattt ttaataagag atacaactaa aataaaaagg
     4861 atagattatt aatgaatatt aaacaattac gctacttttt agtagtagcc gaagaaaagc
     4921 aaatcacttc agcagctaaa agactataca ttgcacaacc gccgctgagt tatcaattaa
     4981 agcaactaga aaaagaacta ggagcacaat tatttaagcg tactgctcat ggaattgaat
     5041 taacagatgc tggacaaatt ttgcagagct atgctagtga aattctctct ttatcagaaa
     5101 gcgtgaaaaa tcaggttcat aaaactgttt caggtgaact aggcacgatt gcaataggca
     5161 tggcttcatc atcaactgga ctaattccta tgaaaagttt tcaagattta actaagtttt
     5221 atccggaaat caactttgat atttatgaag ataatacctt tggcattatc gataaattgg
     5281 aaaagaagac aatcgattta ggaattgtgc gtacgcctta taatcgtaat ggcataaatg
     5341 caaaaacttt aactactgaa agaatgatgg cagttactgt tgatcccaaa tttaaggata
     5401 agacggaatt aaggattaaa gatctaaatg agcagcccct cattatttat cgaagatttg
     5461 aagaaatttt taaccagact tttgctcatc atgggattaa gccgttttat gctgttaaat
     5521 gtgatgattc tagaacagcg attacttggg cgaagagaaa aatggggatt gctcttgttc
     5581 ctgaatctat tgcttctacg tatgcacctg atgatcttat tcctattaaa catagtaatt
     5641 ggattacgca tttgcaatta gtgtggcgca aggatcaaaa ggtgacgcct ttaatgaaga
     5701 gaataataga ttcactaagc cgttaagatt gtaacttcta cctaattgat ccataatttg
     5761 aattaagagg cgatataatg actgacttaa ttcatgttta ttccgaaatt ggcaaattag
     5821 aaacagttat gctgcatcga ccgggaagag aattagaaaa tctttcaccg gatatcttaa
     5881 atcgaatgtt aattgacgat attccatatt taaaaatagc tcaaaaagag catgactatt
     5941 ttgcccacac tttggaaaaa cagggagttc atgtcgttta tttagaagat ttattagctc
     6001 agtctttgac taatgaagat gtccgtacaa aatttgtaga tcaattatta gaagaatcca
     6061 atataaaaaa agaagattca ttacatcaat tactgatgga ctatttaata gcaatgccag
     6121 taaatgaaat ggttaagcaa ataattgctg gtattagaaa aaatgaaata caaaatgtaa
     6181 ctccttcatt agccgatcta gctgaagatc cagattatcc attttatttg aatccaatgc
     6241 caaatgtgta ttttactcgt gatcaacaag cagctattgg taatggcatg actattaatg
     6301 gaatgacgtt tagagctaga agacgtgagt cattatttat ggaaaccgtt ttaaagcatc
     6361 atcccgactt taaaaatgcc aatattccta tttggcgtga tcgttacact catggacgtt
     6421 tagaaggtgg cgatgagctg attttaaaca atcatgtttt agcaatcggt atttctcaaa
     6481 gaacttccgc tgccgcaatc actgaccttg ctcatagcct gtttggtcat tctagttatg
     6541 acacaatttt agcaattaaa ataccacata atcatgccat gatgcatctg gatacagtct
     6601 ttacaatgat taattatgat cagtttaccg ttcatccttt tattttagac aaatcaggaa
     6661 agattgatat ttatgtttta gagcaagatg atcatggtga gattaaaatt accccagaaa
     6721 ctaatttgat caaagtgtta aagaattatt tgcacttatc ggagattgac ctaattccaa
     6781 ccggaggtgg ggatgcaatt gcagccccaa gagagcagtg gaatgatggc tcgaatactt
     6841 tggctattgc gccaggtgaa gtcgttacat atgatcgtaa ttatgtatca aatgatttgt
     6901 taagaaagca tggcatttta gttcatgaaa ttcattcaag tgagctttct cgtggccgtg
     6961 gaggtccaag atgtatgtca tgtccacttg ttcgtgaaga tttgtaagag gcgtcaaaat
     7021 gaaatattta caaaatgtgt ttcaaggcag aagtttatta aaatgcaaag actatactcc
     7081 agcggagctt aactatctaa ttgatttcgc acttcatttg aaggaactaa agaaagaaaa
     7141 tattccgcat gaatatttaa aaggaaagaa tatagctctt ttatttgaaa aatcttcaac
     7201 aagaacacgt tcagcctttg tagttgcatg caatgattta ggtgcaaatc ctgaatatat
     7261 gggtgctggt gaaattcatt taggtaaaaa ggaaagtatt gaagatactg caaaggtttt
     7321 gggcagtatg tttgatggca ttgaatatcg cggttttgct caaaaagatg tagaagattt
     7381 ggctaaatat tctggtgtcc ctgtttggaa tggtttaaca gataaatggc atccgaccca
     7441 aatgttggct gactttatga ctattaaaga aaagtttgga catttaaagg gacttacttt
     7501 agcttatgta ggtgatggac gtgataatgt tgccgacagt cttttagtgg ctggcagcat
     7561 gcttggagtt aatgtacaca tagttacgcc aaagccttta ttcactcacc ctgatgtaca
     7621 aaaaattgca gaaggttttg ccaaagattc tggatcaaga aatttgatta ctgatgatat
     7681 tgaacaaggc gttaaaggtg caaatattat ttatactgat gtctgggtat caatgggtga
     7741 aaatgactgg agtgagagaa tcaaattgtt aaagccttac acggttacaa tgaagatgat
     7801 gcatatgaca ggcacctcgg atgatcaact aatctttatg cactgtttgc ctgcgtttca
     7861 tgatcgcact actaaagttg gcgaagaaat ttataaaaaa tatggtctaa gtgaaatgga
     7921 agttacagat gaagtcttta actctcaata cgcttggcaa tttactgaag cggaaaatag
     7981 attgcattct atcaaagcaa taatggccgc tactttgggc aatttgttta ttccgtcagt
     8041 tgatgaagga agtaaataaa gatgaaaaga atagttgtag ctttgggtgg caatgctatt
     8101 gaagcaggtg ataatagtgc agctgcccaa gaaaagcagg ttgaaaagac aatgaaggtt
     8161 gttgctaaaa tgattgaaaa tggtgatcag gtagcgattg ttcatggtaa tggcccgcag
     8221 gttggtaatt tgcttttgca acaatacaaa ggttcaagta aagataatcc cgctatgccg
     8281 cttgatacag tagtagcaat gactcaaggc agtatcggct attggatgca aaaggcctta
     8341 gacgatcaat ttaaacatac aaattattca catcaagctg ttgctttaat tactcagaca
     8401 atagttaatg cgaatgatcc aacttttaag aatccaacta aaccaattgg cccattttat
     8461 acatttaacg aaatgcagaa gcaaaaaatc tatcatcctg aatatactta taagcaagat
     8521 gcaggtcgag gctatcgtca agtagtttct tctccaaagc ccgttaaaat tattaatgca
     8581 ccagtcattg acactttact aaagagcaag tttgttccta ttgctgccgg aggtggtgga
     8641 attcctgttg tagtgaaaga cgatagtttg caaggcgtag caggagtaat tgataaagac
     8701 ttcagtgccg taaaactagc tgaagatatt caagcagatg aattagttat tctaactact
     8761 gttgacaatg cctacgtgaa ctataatcaa cctgatcaag ctcctattgg aaaaataaag
     8821 attgatcaat taaagaagta tctagaagct ggccaatttg ccgcaggcag catgaagcca
     8881 aaaattgaag ctgtcattga tttcgtagag aaaacaggaa agactgcaat tattacttct
     8941 ttaagaaatg caagtaaact tgatgatgga gtaggtacaa tcgtttataa ttaactgcgg
     9001 tgagatataa atgaacattt ttcaagaagg aaatccgcaa aatattgctc aggtattagc
     9061 tggaaaagat tatcgtgtag ctttgcagca agctattttt aaaaagtatc ctgatgcgac
     9121 tttggttgat ataaacttaa atatcccggg gccaattaaa aataatcgat atttaatcaa
     9181 attatttgat tacggaatta aacaattaga agaaatatgg cagaataagg gatatgacta
     9241 taaattatta aaagcattaa ataatgatgc tggatgtgaa aatttctatg ttttgcgaga
     9301 atctagcaaa gtagttaaat tatctacaat tttatttgaa gaaaataata aaataggacg
     9361 attatttgat gccgatgtat taattaaagg gaaacctgca ctttcacgcc aagagcttga
     9421 atactctagt cgccgctgct atttatgcaa tcgccctgct aaagagtgtg ctcgatcacg
     9481 gcgacactca gtagaagaga tgcaaagata catttctagt ttatatgcga agtatgtaaa
     9541 taattaaaac gggatgggag gctaatcatc ccgttttttc atttaaatct aaaaaaaagc
     9601 taacgaaaaa tgcataaaat gttctaaaat ataagtaaag ttatgaatat atattgtaag
     9661 gaaaactatg aaattaaaga aaaaccaaga cgatttaaaa caaattgctt cattgattga
     9721 atatgctttt ttaaaagatt ctgatttgac tacagatagt aactttatga cccgatatga
     9781 tcatagtgct ggatatggat attttgatca agaaaaattg accagttata tgatggtcaa
     9841 taagtttaaa gctgagatat ttggtcatca tgttccattg gcaggtattg gttatgtggc
     9901 atcatatcct gaatacagag gacgtggaca tatatctaaa ttaatgaaag aaattctttt
     9961 tgatttgcat gatcaaaaaa tcctagttgc aaatctagct ccattttcag aaaattttta
    10021 tcgtcattat ggttttagca atagtattta ccaaaaagaa tatggctttt cgggggctgc
    10081 acttgcttct ttcagattac cacgcaaagg taagataatt cgtggaaaat ggaatgattt
    10141 gattgttcaa aatggtgtga ttcaattata tgaacgtcag ttgcatactg acgatgaaag
    10201 aaatacgatc atcagagaag cttggtggtg gaatagatta gatgattatt atcatcatcg
    10261 agagattgct gtttacttcg atgaagctgg tcggccgatg agctacttga tttatcgcat
    10321 aattgataac tgttttatgg ctgatgaatt atattcaatt acgcctcaag gattattaag
    10381 catattaggc tttatggtag ctcatatagg gtcaattaaa gagttttgta tgacattgcc
    10441 tgagaagtct ttattggctg aactttttcc agagcaaaat gaattggata ttcaacttca
    10501 tccatatatg atgagtagaa ttattgattt ccaaaaaatc ttgtcatgca tgcgcccatt
    10561 gcaagagggt acttttaaca tcgaagttaa ttatgatgat cagtgtccat ggaatattgg
    10621 cgtttggcaa ttaactaatt atgatcacca agttaagtgt gaacgaaaag aagatgaact
    10681 agttgatttc tctggtccaa ttacaacatg gactcaaatc ttattaggac gtttaactat
    10741 ggaatccgca attaaacttg gtttgatcac agattatcga attaaaaagt tggactttat
    10801 aaaaggtaaa gtctcatttt atgattattt ttagaagaag gtatctaaaa tgagtaagca
    10861 aaagaaagtt agattactaa aatttttaag cgtggtagtt agtggaataa atgtggttat
    10921 ttcgctattg attatgctca acaaatatca aattagaaaa gataaaaaac aaatagcaga
    10981 tgaaggtcat gccccattgg atgaaaatta actatgaaaa aattgagaat agcatacttt
    11041 aaccaacttg gtagaagaca attagatcga attgtagacc aatttaagca aaaaaattct
    11101 gatgtagaaa ttgaattaat tggaatggga cacgatgaag cttttgataa attagccaaa
    11161 aatgaagttg atttagcgat tagtgatttg cgcgatgatc agctcgattt taagaaggaa
    11221 atcttaggtc aggaagcagt aatggctatt ttgcaaaagg gtagttatcc tagcggtgtt
    11281 cagatgatca ataaagatga tctagctgat ttaacctgtt ttattgtagc taagcctgaa
    11341 gaagaggctg cagaactcca tttatttaaa gatatttatc agattagaag cccattcatt
    11401 gcttcaaatt ccgtagaaga ggcagcattg ttagtagctt ctggatcagg atatttttta
    11461 atgaatgaag caaccgccag tttaattagt aatgatactt tacaacgatt gtttttattg
    11521 tctaatggac aacaaatgtg gcaaaagatt gcagcttttt ataccaatga agatgcagta
    11581 attaaagatt ttattttgtt agttaaaaaa gtatattaat ctatcttgga acagcaaaat
    11641 actgtaaaat taataatgaa agcgaatcca taattttaca actggagatg attttatgct
    11701 agagagaaaa ttattgcctt tgtcagccat ggtactggct ttaggcttga gcggattaac
    11761 aacgcatgta aaggcagctg acaccccact tatggtaatg gtaacggagc ggttgtgact
    11821 gtgcataaga agatgcaggg gacatggtac tcatatgata gtaatgcaca tagcggtaga
    11881 aaaattactt ttactgcgca tacggttaat ggaaaaatca attacactca agacaaatca
    11941 attattagcg attactttaa tggcaatatt caagatcagg ctggctttga tcgagctacc
    12001 aaaaattgga tgtcaggtca aacaactaag atgaaaaata atctatttta tgagattaat
    12061 ccatggatta gttttgaaaa ttggagtcta tatagagtaa tgcctcaaaa gattaatggt
    12121 aaaaagcata atgttttact gtattcaagt agatacgatg gcggcaatta ctatagaagc
    12181 aagaaattgg ctaaacaaat gaaaaattat aagtttaaaa aggtagacta tcatttgtaa
    12241 aatttaatat agaagaaaag cttcaaatta tagaaattat gttaagttga ttttggcagt
    12301 aacttttttg aaaaaatagt ttataatatc aataaaaatt aatttggtag gaataaaaaa
    12361 taaaattaga gaatgcacct gttttaaatt tatttagatt agaaataaat cctgaaaagc
    12421 atgaaatata tactaaaaaa gtggaaaagt atatgttaaa tgcaaagaat gcattattta
    12481 tgcagagcgg tcatgaagat caaaggaaat ataaaaacta cttgatagaa agttatcaaa
    12541 atgacgatgc ttatcaaaaa catgagtctt taagtcaagt ccagcaattt gaacgtgatc
    12601 tgaaagatat tgtaaatagt caagttaaag taaaattata tcctgaattt atttcaacta
    12661 agccagaaaa gttagctatt acgcacgata atcaatatgt ggtttattta actgaaattg
    12721 gtgtgcagtt gggtaagggc gatgaattcg ccaatgcagt aatgaaagaa atgaaaactg
    12781 cggttgaaaa agaagacggc atcttggcaa tgattgctgg tactattatg aatcaaccga
    12841 atgaatggtt ttcattagaa gtatacaaaa ctgaagaaac atacgaggaa tatcataaga
    12901 ctaaacactt caaaaaatat ctagaagcta ccaagtatgt ggtagaaagt aaaggtcttc
    12961 acctacttaa acctgattgt ataatggatc aaggagaaat tttctatcga ccataagaaa
    13021 aagcaagtta tttagttgaa aaataacttg ctttttgaat tatttgcaat tgtttcgatt
    13081 ctttacttta acagggagag gcttattaac taacgtagag ctgatagcca tgattcctgc
    13141 agttgctaac gcaactgtaa tggagaccgt aaaatagttt gtgtaaggat gaatgattcc
    13201 ttaaattaat ttctgaaaac attagaaaaa ggagttcctt tctcgtatga ttggattgaa
    13261 caaaaaaaca acatacagaa agaagaactc cttcatgaat gattttacca aaaatatggc
    13321 tcaagcacta ttcaatcaag acaaagttaa tgattttttg cgcaaggaaa ttcaaactgc
    13381 agttaatcaa ttgcttgaag ctgaattgac tgccttttta ggctatgatc cttatgca
//
