LOCUS       gnlProkkaMEGCPJPM_15    6218 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MEGCPJPM_15.
ACCESSION   gnlProkkaMEGCPJPM_15
VERSION     gnlProkkaMEGCPJPM_15
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 10:27:34
            Original ID  :: gnl|Prokka|MEGCPJPM_15
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6218
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..3885
                     /NRPS_PKS="Domain: AMP-binding (271-663). E-value:
                     3.5e-111. Score: 363.5. Matches aSDomain:
                     nrpspksdomains_ctg15_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (770-837). E-value: 5.8e-28. Score:
                     88.8. Matches aSDomain: nrpspksdomains_ctg15_1_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (854-1138). E-value:
                     1e-103. Score: 338.3. Matches aSDomain:
                     nrpspksdomains_ctg15_1_Condensation_LCL.1"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     342.9; E-value: 4.3e-104)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_1"
                     /sec_met_domain="AMP-binding (E-value: 7.9e-120, bitscore:
                     387.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.4e-19, bitscore:
                     56.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 9.9e-88, bitscore:
                     281.1, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYLADYEEQTIVPNLGVHPEQEGYRSESVICELGQALTHQIQQIA
                     ARNQVTMNTVMQAIWGVLLQKYNNSNDVVFGSVVSGRPEGIPGIENMIGMFINTIPVRV
                     QTRTGITCADLMQNIQELAISSSSYDTYPLYEIQAQTKQKQDLVQHIMVFENYPVEQEV
                     GHGDISDKTKLKITNFRGDEHTNYDFNVLVMPGREMQVHLQYNANVYSRVGVEQIKDHL
                     IHLMNQVVQNPNMLIEDLQLITKEEEQQILQDFNDTKAEYPRNKTIHQLFEEQAERVPD
                     KVAVVFEDKQLTYRGLNERANRLARTLRNEGVEADQLVGIMAERSLDMIVGILGILKAG
                     GAYVPIDPEYPEERIHYMLEDSKAHLLLTQSHLRDRISFAGKILSLDEEDSYDETGSNL
                     KSIVEPHHLAYVIYTSGTTGKPKGVMVEQQNVISLVKNPNYVELDGDTHILQTGSLVFD
                     ASTFEIWGAILNGGQLYLTKIEQILDVCELKGLIKKYKINTMWLTSPLFNKLTNQDNFL
                     FEELKTLIIGGDILSLPHINQVCENNPQINIVNGYGPTENTTFSSTYLVRGKQSQAIPI
                     GRPIQNSTAYVVDKTLNIQPIGVWGELLVGGDGVARGYLDRPELTAEKFIQLPFNNDRC
                     YRTGDIARWTSNGVLEFRGRLDHQVKINGYRIEIGEIETALLNIDAVQEAIVTTCEDGN
                     SDKELCAYLVVREQFKVSHIKQKLSSSLPSYMVPTYFVRLQNFPLTVNGKIDYKALPLP
                     DRNTQTGVKYIAPRTRIELKLAEIWKEVLGLKQVGIQDNFFDIGGHSLRATGLVAKIHT
                     ELNVSISIRDVFNHPTIEEMASVIMKLGSDGYDLIPSVKQKDYYPVSSAQKRMYILNQI
                     DGNELTYNMPQMFQVAGALDLERLENSLRQLVNRHESFRTSFKIIQGEIVQQIHEDVDF
                     TFETIKVSNSEIEEHQVQFVRPFDIMQAPLIRVKLLKLASNDHILMLDMHHIISDGASM
                     KIFIDELMDLYEGKQLTELRIQYKDYSCWRLNQKQIKKMMKQEAYWMDMFRGEIPLLDM
                     PTDYERPLIRSYEGDLLEFDIDSNIYKGLLKLAEETESTLYMVLLAAYFILISKYSGQE
                     DIIVGTPIAGRNHTDIEKIIGMFVNTVVVRSYPNGEKTFLQYVLDVKETMLGIYENQDY
                     PFEELIEKVNFQKMGDRNPLFDTMFAIQNTDETILNRGNLHFKPIINHMHKVSKFDLTL
                     SINVSQTKLTGSFEYCTKLFRKKSIEIMSKNLITILSTITSNPNIKLGRIELGVNKKDT
                     NAIDLYELRL"
     protocluster    1..6218
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:6216]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..6216
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..6218
                     /SMILES="NC(C(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..6218
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /tool="antismash"
     CDS_motif       214..309
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_1_0001"
                     /evalue="5.30E-19"
                     /label="C5_DCL_263-294"
                     /locus_tag="ctg15_1"
                     /protein_end="103"
                     /protein_start="71"
                     /score="60.6"
                     /tool="antismash"
                     /translation="DVVFGSVVSGRPEGIPGIENMIGMFINTIPVR"
     CDS_motif       367..474
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_1_0002"
                     /evalue="3.20E-12"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="ctg15_1"
                     /protein_end="158"
                     /protein_start="122"
                     /score="38.8"
                     /tool="antismash"
                     /translation="AISSSSYDTYPLYEIQAQTKQKQDLVQHIMVFENYP"
     aSDomain        814..1989
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg15_1_AMP-binding.1"
                     /evalue="3.50E-111"
                     /label="ctg15_1_AMP-binding.1"
                     /locus_tag="ctg15_1"
                     /protein_end="663"
                     /protein_start="271"
                     /score="363.5"
                     /specificity="substrate consensus: Val"
                     /tool="antismash"
                     /translation="FEEQAERVPDKVAVVFEDKQLTYRGLNERANRLARTLRNEGVEAD
                     QLVGIMAERSLDMIVGILGILKAGGAYVPIDPEYPEERIHYMLEDSKAHLLLTQSHLRD
                     RISFAGKILSLDEEDSYDETGSNLKSIVEPHHLAYVIYTSGTTGKPKGVMVEQQNVISL
                     VKNPNYVELDGDTHILQTGSLVFDASTFEIWGAILNGGQLYLTKIEQILDVCELKGLIK
                     KYKINTMWLTSPLFNKLTNQDNFLFEELKTLIIGGDILSLPHINQVCENNPQINIVNGY
                     GPTENTTFSSTYLVRGKQSQAIPIGRPIQNSTAYVVDKTLNIQPIGVWGELLVGGDGVA
                     RGYLDRPELTAEKFIQLPFNNDRCYRTGDIARWTSNGVLEFRGRLDHQVKIN"
     aSModule        814..2511
                     /complete
                     /domains="nrpspksdomains_ctg15_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg15_1_PCP.1"
                     /locus_tags="ctg15_1"
                     /monomer_pairings="Val -> Val"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1000..1041
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_1_0003"
                     /evalue="5.10E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg15_1"
                     /protein_end="347"
                     /protein_start="333"
                     /score="19.5"
                     /tool="antismash"
                     /translation="LGILKAGGAYVPID"
     CDS_motif       1225..1281
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_1_0004"
                     /evalue="1.50E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg15_1"
                     /protein_end="427"
                     /protein_start="408"
                     /score="32.9"
                     /tool="antismash"
                     /translation="AYVIYTSGTTGKPKGVMVE"
     CDS_motif       1786..1875
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_1_0005"
                     /evalue="1.20E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg15_1"
                     /protein_end="625"
                     /protein_start="595"
                     /score="55.9"
                     /tool="antismash"
                     /translation="PIGVWGELLVGGDGVARGYLDRPELTAEKF"
     CDS_motif       1954..2019
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_1_0006"
                     /evalue="3.60E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg15_1"
                     /protein_end="673"
                     /protein_start="651"
                     /score="31.9"
                     /tool="antismash"
                     /translation="FRGRLDHQVKINGYRIEIGEIE"
     aSDomain        2311..2511
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg15_1_PCP.1"
                     /evalue="5.80E-28"
                     /label="ctg15_1_PCP.1"
                     /locus_tag="ctg15_1"
                     /protein_end="837"
                     /protein_start="770"
                     /score="88.8"
                     /tool="antismash"
                     /translation="ELKLAEIWKEVLGLKQVGIQDNFFDIGGHSLRATGLVAKIHTELN
                     VSISIRDVFNHPTIEEMASVIM"
     aSDomain        2563..3414
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg15_1_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.00E-103"
                     /label="ctg15_1_Condensation_LCL.1"
                     /locus_tag="ctg15_1"
                     /protein_end="1138"
                     /protein_start="854"
                     /score="338.3"
                     /tool="antismash"
                     /translation="YYPVSSAQKRMYILNQIDGNELTYNMPQMFQVAGALDLERLENSL
                     RQLVNRHESFRTSFKIIQGEIVQQIHEDVDFTFETIKVSNSEIEEHQVQFVRPFDIMQA
                     PLIRVKLLKLASNDHILMLDMHHIISDGASMKIFIDELMDLYEGKQLTELRIQYKDYSC
                     WRLNQKQIKKMMKQEAYWMDMFRGEIPLLDMPTDYERPLIRSYEGDLLEFDIDSNIYKG
                     LLKLAEETESTLYMVLLAAYFILISKYSGQEDIIVGTPIAGRNHTDIEKIIGMFVNTVV
                     VRS"
     CDS_motif       2629..2739
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_1_0007"
                     /evalue="1.40E-15"
                     /label="C2_LCL_024-062"
                     /locus_tag="ctg15_1"
                     /protein_end="913"
                     /protein_start="876"
                     /score="49.6"
                     /tool="antismash"
                     /translation="TYNMPQMFQVAGALDLERLENSLRQLVNRHESFRTSF"
     CDS_motif       2935..3000
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_1_0008"
                     /evalue="2.00E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg15_1"
                     /protein_end="1000"
                     /protein_start="978"
                     /score="33.1"
                     /tool="antismash"
                     /translation="MHHIISDGASMKIFIDELMDLY"
     CDS_motif       3322..3411
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_1_0009"
                     /evalue="9.70E-16"
                     /label="C5_LCL_267-296"
                     /locus_tag="ctg15_1"
                     /protein_end="1137"
                     /protein_start="1107"
                     /score="50.1"
                     /tool="antismash"
                     /translation="DIIVGTPIAGRNHTDIEKIIGMFVNTVVVR"
     CDS_motif       3460..3576
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_1_0010"
                     /evalue="9.70E-14"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ctg15_1"
                     /protein_end="1192"
                     /protein_start="1153"
                     /score="43.6"
                     /tool="antismash"
                     /translation="KETMLGIYENQDYPFEELIEKVNFQKMGDRNPLFDTMFA"
     CDS             4051..6216
                     /NRPS_PKS="Domain: AMP-binding (265-663). E-value:
                     6.4e-118. Score: 385.7. Matches aSDomain:
                     nrpspksdomains_ctg15_2_AMP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     333.6; E-value: 2.9e-101)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_2"
                     /sec_met_domain="Condensation (E-value: 5.7e-12, bitscore:
                     32.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1e-125, bitscore:
                     406.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLFEEQELFWDGVFDDEDYISYLPYFKTTVKDDGKRGRVTDSIL
                     YVSLPTELSQKIKSVANDSHIAVYIILLSGVECLLNKYTGNENIIIGMPAIKQDIGVLN
                     EILMLKNKINAATTFKTLFKDINLFLKSVTENQNVPFRKMTKNLNIQYNDEHLPIINTV
                     VSLDEIHSSFLNEIGGRDILFQFNLENNRVNLKVVYNERRYDQEYLVQATEHLKQIYTN
                     MLSQPDSRLDQLEYLSKVETDKIFLEFNDTQADYPSNKTIHQLFEQRAESLPNKVAVEF
                     EDKQLTYQELNERANQLARTLRLNGVGSEQLVGIMTERSLEMIIGILGILKAGGGYVPI
                     DPEFPEERIHYILKDSEAQLLLTQSHLMHRVSFTGRVIPLDSEESYHEIQTNLNSIVRP
                     NHLAYVIYTSGTTGKPKGVMIEHKSVVNTLTDLEKRFPLGIDDAILLKTNYTFDVSVTE
                     LFGWFIGKSKLVILKPGLEKEPEALINIIEKNKITHINFVPSMLQVLLNELRQINIKKL
                     QSLKYVFSAGEALPVKTIKEFYSALSSRLENIYGPTECTIYATYYGTDRTMKGLVNTPI
                     GKPLGNVQAVVLKDLELQPIGVPGELCISGVGLARGYLNRPDLTAEKFVDHPFIPGEKL
                     YRTGDLARWLPEGNIEYLGRIDHQVKIRGYRIEIGEIETVLLNMEAVQEAIVVAHEDDN
                     GDKALCAYYVASESFAVSEMKEKLSVQM"
     aSDomain        4846..6039
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg15_2_AMP-binding.1"
                     /evalue="6.40E-118"
                     /label="ctg15_2_AMP-binding.1"
                     /locus_tag="ctg15_2"
                     /protein_end="663"
                     /protein_start="265"
                     /score="385.7"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="FEQRAESLPNKVAVEFEDKQLTYQELNERANQLARTLRLNGVGSE
                     QLVGIMTERSLEMIIGILGILKAGGGYVPIDPEFPEERIHYILKDSEAQLLLTQSHLMH
                     RVSFTGRVIPLDSEESYHEIQTNLNSIVRPNHLAYVIYTSGTTGKPKGVMIEHKSVVNT
                     LTDLEKRFPLGIDDAILLKTNYTFDVSVTELFGWFIGKSKLVILKPGLEKEPEALINII
                     EKNKITHINFVPSMLQVLLNELRQINIKKLQSLKYVFSAGEALPVKTIKEFYSALSSRL
                     ENIYGPTECTIYATYYGTDRTMKGLVNTPIGKPLGNVQAVVLKDLELQPIGVPGELCIS
                     GVGLARGYLNRPDLTAEKFVDHPFIPGEKLYRTGDLARWLPEGNIEYLGRIDHQVKIR"
     CDS_motif       5032..5073
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_2_0001"
                     /evalue="1.90E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg15_2"
                     /protein_end="341"
                     /protein_start="327"
                     /score="17.8"
                     /tool="antismash"
                     /translation="LGILKAGGGYVPID"
     CDS_motif       5257..5316
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_2_0002"
                     /evalue="9.60E-12"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg15_2"
                     /protein_end="422"
                     /protein_start="402"
                     /score="36.5"
                     /tool="antismash"
                     /translation="AYVIYTSGTTGKPKGVMIEH"
     CDS_motif       5833..5922
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_2_0003"
                     /evalue="2.30E-19"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg15_2"
                     /protein_end="624"
                     /protein_start="594"
                     /score="61.4"
                     /tool="antismash"
                     /translation="PIGVPGELCISGVGLARGYLNRPDLTAEKF"
     CDS_motif       6004..6069
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_2_0004"
                     /evalue="5.80E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg15_2"
                     /protein_end="673"
                     /protein_start="651"
                     /score="37.5"
                     /tool="antismash"
                     /translation="YLGRIDHQVKIRGYRIEIGEIE"
ORIGIN
        1 gagtatttag ccgactatga agaacaaaca attgtaccaa atctaggagt acatcctgaa
       61 caagagggat atcgttcaga gagtgttatt tgtgaattgg gacaagcact aacccatcaa
      121 attcagcaaa tcgcagctcg caatcaagta acaatgaaca cagtaatgca agcaatatgg
      181 ggtgttttat tacaaaaata taataatagt aatgatgttg tatttggcag tgtggtatca
      241 ggaagaccgg aagggattcc tggaattgaa aatatgattg gcatgtttat taacacgatc
      301 ccggtacgag tacaaactag aacagggata acttgtgctg atttaatgca aaacatacaa
      361 gaactcgcga tttcatcaag ttcgtatgat acgtatcctc tttatgaaat acaggctcaa
      421 acaaagcaaa aacaagactt ggttcagcat attatggtgt ttgagaatta tccggttgaa
      481 caagaagtag gacacggtga tatatcggat aagacaaaat tgaaaattac aaattttcga
      541 ggagacgagc acaccaacta tgattttaac gtactagtga tgccagggag agaaatgcag
      601 gttcaccttc aatataatgc gaatgtgtat agtcgggtgg gcgtagaaca aatcaaggat
      661 cacctgattc atcttatgaa tcaagttgtg caaaatccaa atatgcttat tgaggattta
      721 caattaatca ccaaagaaga ggagcaacaa atcctacagg atttcaatga cacaaaagcg
      781 gaatatccaa gaaacaaaac aattcatcaa ctgtttgaag aacaagcaga acgtgtgcca
      841 gataaggtag ctgttgtgtt tgaagataaa caattgacat atcgtggact gaatgagcgc
      901 gctaatcgac tagcccgcac acttcgaaac gaaggtgtag aggctgatca gctcgttggg
      961 attatggcag agcgttcttt agacatgatc gtggggatac tcggtatcct taaggccggg
     1021 ggagcgtatg taccaattga tccggagtat ccagaagagc gaatccatta tatgttagaa
     1081 gattcaaaag cgcacttatt attaacccaa agtcatttgc gagatcgaat atcgtttgct
     1141 gggaagatat tgtcccttga tgaagaagac agctatgatg aaactggatc taatctgaaa
     1201 tctattgtag agcctcacca tctggcatat gtaatatata cttcaggaac gactgggaaa
     1261 ccaaaaggag ttatggttga acaacaaaat gtaattagct tggtcaaaaa cccgaattat
     1321 gtagagctag atggggatac gcatattttg caaacagggt ctctggtatt tgacgcctct
     1381 actttcgaga tttggggagc tatattaaat ggaggacaac tctatttaac aaaaattgaa
     1441 caaattctgg atgtttgtga gttaaaagga ttaattaaga aatacaaaat taatacaatg
     1501 tggttaacat ccccattatt taacaaactt acaaaccagg acaatttttt atttgaagaa
     1561 ttaaagacgt tgattatagg aggggatata ttatctttac ctcatattaa tcaagtgtgt
     1621 gaaaacaatc cgcagataaa tatagtaaat ggttatggcc ctactgaaaa cacaactttt
     1681 tcctctactt atttggttag aggcaaacaa tctcaggcaa tacctattgg tcggcctatt
     1741 caaaattcaa cagcttacgt agtagataaa acattaaata tacaacctat aggagtatgg
     1801 ggggaattac ttgttggtgg agatggtgta gcgagaggtt atctagatag acctgagctt
     1861 actgcagaga aatttataca acttccattt aataatgatc gctgttatcg cacgggagat
     1921 atagctcggt ggacgtctaa tggagtatta gaatttagag gaaggcttga ccatcaagtt
     1981 aagataaacg gataccggat tgaaattggg gagattgaaa cagctttatt gaatatagat
     2041 gctgtgcaag aagcaattgt caccacatgt gaggatggaa attctgataa agaattatgt
     2101 gcttatttag tagttagaga gcagttcaaa gtaagccaca ttaagcaaaa attatcttct
     2161 tctctgccaa gctatatggt tccaacttac tttgtaaggc tgcaaaattt tcctttaaca
     2221 gtcaacggga aaattgatta caaggctctc cctctgcctg atagaaatac acaaactggt
     2281 gtgaaatata ttgcgcctcg tacacgaatt gaattaaagc tggctgagat ttggaaagag
     2341 gtacttggtt taaaacaagt gggaatacaa gataacttct ttgatatagg tgggcattct
     2401 ttgcgagcga cgggtttagt tgccaaaatt catacagaac taaatgttag tatttcaata
     2461 agagatgtgt tcaatcatcc aacaattgag gaaatggcgt cagttattat gaaattgggt
     2521 tcggatggat atgacttaat tccttctgta aaacaaaaag actattaccc tgtatcttca
     2581 gcacaaaaac ggatgtatat cttgaatcaa atagatggta atgaattaac ttataatatg
     2641 ccacaaatgt ttcaagtagc aggggcatta gatctagaga gattagaaaa ttccttaaga
     2701 caattggtta atcgacatga atcgttccgc acaagcttta aaataattca aggtgaaatt
     2761 gtacaacaaa tacatgaaga tgttgatttc acatttgaaa cgataaaagt ttctaatagt
     2821 gaaatagagg aacatcaggt tcagtttgtt cgaccatttg atataatgca agcaccttta
     2881 attagagtga aactgctaaa attggcatca aatgaccata tactaatgtt agatatgcat
     2941 catatcattt cggatggagc gtcgatgaaa atttttatcg atgaacttat ggatttatat
     3001 gaaggtaagc aattaactga acttagaatt cagtataagg attattcttg ttggagatta
     3061 aatcaaaagc aaattaaaaa aatgatgaag caagaagcat attggatgga tatgtttaga
     3121 ggagaaatac cgctgctaga tatgcctact gattatgaaa gacctttaat tagaagttat
     3181 gaaggggacc tattagaatt tgatattgat tctaatatct acaagggatt actaaaatta
     3241 gcagaagaaa ctgagagtac attgtatatg gtattgttgg cggcatattt catcttgata
     3301 tcaaaatata gtggtcagga ggacatcata gtaggtacac cgatagcagg tcgaaatcat
     3361 acggacattg aaaagataat aggaatgttt gtaaatactg tggttgttag aagttatcca
     3421 aatggagaga aaactttttt acaatatgtt ttagatgtaa aggaaacaat gttaggtatc
     3481 tacgaaaacc aagattatcc attcgaggag ttaattgaga aagttaattt tcaaaaaatg
     3541 ggtgatcgta atcctttatt tgatacaatg tttgctattc aaaatacaga tgaaacaatt
     3601 cttaatagag ggaacctcca tttcaaacct ataattaatc acatgcataa ggtgtcaaaa
     3661 tttgatttaa cattatccat taatgttagt caaactaaat taacgggaag ttttgaatac
     3721 tgcacaaaat tattcaggaa gaaatctatc gaaataatgt cgaaaaattt aattactata
     3781 ttatcaacaa ttacttctaa tcctaatatc aaattaggtc gaattgaact tggcgtaaac
     3841 aagaaagata ctaatgctat tgatttatat gaactccgtc tataaattgc tcttaattag
     3901 aaatatttta gacttaagtt taattttctc aagtaaccca tcactggggt tacttgagct
     3961 ttatacaaat aaagcttact gagttcaata aaaagagttt tcaaaatttg aaattaatga
     4021 atccagaata taagtaaaga ggtgttgtaa gtgtctttat ttgaagagca agaactattt
     4081 tgggacggtg tttttgatga tgaagactat atatcctact tgccctattt taaaacaaca
     4141 gtaaaagatg atggtaagag aggtagggtt acggattcta ttctttacgt ttcattaccg
     4201 actgaattat cacaaaaaat taagtcggta gctaatgact cgcacattgc agtgtatatt
     4261 attctattat ctggagttga atgtttatta aataaatata ccggaaatga aaacattatc
     4321 ataggaatgc cagcgataaa acaagatata ggtgttttaa atgaaattct catgttgaaa
     4381 aataaaataa atgcggcgac cacatttaaa acattattta aagatattaa tttgttttta
     4441 aaaagtgtaa cagaaaacca aaatgtacct ttccgaaaaa tgacaaagaa tttaaatata
     4501 caatataatg atgaacattt gccgataatt aacactgttg tttctttaga tgagatacac
     4561 tcttcttttc ttaatgaaat tggcggaagg gatattctgt ttcaatttaa tctagaaaat
     4621 aatagagtga atcttaaagt cgtatataac gagagacgtt atgaccaaga atatctggtg
     4681 caagctacag agcatttaaa acaaatttat actaatatgt tatctcaacc agattctagg
     4741 ctagatcaat tagaatactt atctaaggtt gaaacagaca aaatatttct cgagtttaat
     4801 gatacacaag cagattatcc aagtaataaa acaattcatc aattgtttga acaacgggca
     4861 gaatctttac caaataaagt agccgttgaa tttgaagata aacaattgac atatcaagaa
     4921 cttaatgagc gagccaatca gttggctcgg actctccgat taaatggtgt aggttcggaa
     4981 caactagtgg gcattatgac agaacggtct ctggaaatga ttataggtat acttggtatt
     5041 ctcaaagctg ggggaggata tgtaccgatt gatcctgaat ttcctgaaga acgaattcat
     5101 tatatattaa aggattcaga agctcagctg ttactgactc aaagtcattt aatgcatcgt
     5161 gtatcattca ctgggagagt aattcctctc gactccgaag agagctacca cgaaattcaa
     5221 actaatctta attcaatagt gaggccaaat catttggctt atgtaatata cacttcaggg
     5281 acaacaggta aaccaaaggg tgtaatgatt gaacataaat cagtagtgaa tactttaacg
     5341 gatttagaaa aaaggtttcc tttggggata gacgatgcca tattattgaa aacaaactat
     5401 acatttgatg tatctgtaac agaactgttt ggctggttta tcggaaaaag caaattagtt
     5461 attcttaagc caggtttaga gaaggaacca gaagcattaa taaatattat agaaaaaaat
     5521 aaaattactc atattaattt tgtaccctct atgttacaag tattgttgaa tgaattaagg
     5581 caaataaaca taaaaaagct tcaatctttg aaatatgtat tttctgccgg tgaagcattg
     5641 ccagttaaaa caattaagga gttttattct gcattatcat cacgattgga aaatatttat
     5701 ggtccgacag agtgtaccat atatgcaacc tattatggaa ccgatagaac tatgaaaggt
     5761 cttgtaaaca cgcctattgg taaaccatta ggaaatgtac aagcagttgt tttaaaagat
     5821 ttggaattac agcctatagg agtccccgga gaattatgta tcagtggagt tggtttagct
     5881 cgaggctact taaaccgccc tgacttaacg gccgaaaagt ttgtcgatca tccgtttatc
     5941 cctggtgaga aattgtatcg aacaggagac cttgccagat ggttaccgga aggtaacatt
     6001 gagtatttag ggcggattga ccatcaagta aaaatacgcg gataccgtat tgaaattggg
     6061 gaaattgaga cagttttatt gaatatggaa gctgtacaag aagcaatcgt ggttgcgcat
     6121 gaagacgaca atggagataa agcgttatgt gcatactacg ttgcgagtga atcttttgcg
     6181 gtcagtgaga tgaaagagaa attatctgtc caaatgcc
//
