LOCUS       gnlProkkaCOEDGJGN_27   22206 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|COEDGJGN_27.
ACCESSION   gnlProkkaCOEDGJGN_27
VERSION     gnlProkkaCOEDGJGN_27
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 11:28:06
            Original ID  :: gnl|Prokka|COEDGJGN_27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 22206
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22206
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1:2206]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2..2206
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..22206
                     /SMILES="NC(CC(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..22206
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             2..2206
                     /NRPS_PKS="Domain: AMP-binding (1-322). E-value: 2.6e-89.
                     Score: 291.5. Matches aSDomain:
                     nrpspksdomains_ctg22_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (430-494). E-value: 7.6e-23. Score:
                     72.4. Matches aSDomain: nrpspksdomains_ctg22_1_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (518-727). E-value:
                     5.4e-25. Score: 81.0. Matches aSDomain:
                     nrpspksdomains_ctg22_1_Thioesterase.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     277.7; E-value: 2.5e-84)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_1"
                     /sec_met_domain="AMP-binding (E-value: 6.3e-105, bitscore:
                     345.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4e-13, bitscore:
                     44.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGAYVPIDPEYPEERIHYMLEDSKAHLLLTQSHLRDRISFAGKIL
                     SLDEEDSYDEAESNLKSIVEPHHLAYVIYTSGTTGKPKGVMVEHRGLCNLTTHFKENLH
                     MNEHDRVVQFASISFDAAVWEVFTSLLLGAKLYIPKKLEIIDHHLFVKFMNDKKITTAL
                     LPPTYIRYLTPENFSSLKRLITGGSAITVDLMTKWKENLLYLNAYGPTEDSIITTVWKG
                     LEENIQPYIVPIGRPIPNHNVYILNTSDQLQPVGVPGELCISGVGLARGYLNRPDLTAE
                     KFVDHPFIPGEKLYRTGDLARWLPEGNIEYLGRIDHQVKIRGYRIEIGEIETALLNMEA
                     VQEAIVVAHENDNGDKALCAYYVASESFAVSEMKEKLSVQMPSYMLPSYFIQLEKMPLT
                     SNGKIDRKELPLPDEKNIQTGVEYVAPRTPIETKLAEIWKDILDIKQVGIQDNFFDIGG
                     DSLKVLKLIQSIKERMRTEISFQTVFNAQTIELLALDLMNGNIKLEDETKFTPITHRGN
                     VNVFCFPSRIGIGMTYIEMAYLLEGDYRIYITDFIHDHTNFDDMIREYAENIVQIQEQG
                     PYVFLGYSGGGNIAFEVAKVMEKKGLEVSDIIMLDTTLWNAEVNKRAMKMLSEVNREHT
                     KVPEWMNTKYVQNKINKFTMYLEQLTNEGVLDSNIHNIVIDNSMTKFKKEWANATTKDY
                     IEYDGYGTHDEILQPEYIDKNVSIVKEILKNINKSVMTSI"
     aSDomain        5..967
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_1_AMP-binding.1"
                     /evalue="2.60E-89"
                     /label="ctg22_1_AMP-binding.1"
                     /locus_tag="ctg22_1"
                     /protein_end="322"
                     /protein_start="1"
                     /score="291.5"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="GAYVPIDPEYPEERIHYMLEDSKAHLLLTQSHLRDRISFAGKILS
                     LDEEDSYDEAESNLKSIVEPHHLAYVIYTSGTTGKPKGVMVEHRGLCNLTTHFKENLHM
                     NEHDRVVQFASISFDAAVWEVFTSLLLGAKLYIPKKLEIIDHHLFVKFMNDKKITTALL
                     PPTYIRYLTPENFSSLKRLITGGSAITVDLMTKWKENLLYLNAYGPTEDSIITTVWKGL
                     EENIQPYIVPIGRPIPNHNVYILNTSDQLQPVGVPGELCISGVGLARGYLNRPDLTAEK
                     FVDHPFIPGEKLYRTGDLARWLPEGNIEYLGRIDHQVKIR"
     aSModule        5..2182
                     /complete
                     /domains="nrpspksdomains_ctg22_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg22_1_PCP.1"
                     /domains="nrpspksdomains_ctg22_1_Thioesterase.1"
                     /final_module
                     /locus_tags="ctg22_1"
                     /monomer_pairings="Leu -> Leu"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       209..268
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg22_1_0001"
                     /evalue="9.30E-12"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg22_1"
                     /protein_end="89"
                     /protein_start="69"
                     /score="36.5"
                     /tool="antismash"
                     /translation="AYVIYTSGTTGKPKGVMVEH"
     CDS_motif       761..850
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg22_1_0002"
                     /evalue="2.50E-19"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg22_1"
                     /protein_end="283"
                     /protein_start="253"
                     /score="61.3"
                     /tool="antismash"
                     /translation="PVGVPGELCISGVGLARGYLNRPDLTAEKF"
     CDS_motif       932..997
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg22_1_0003"
                     /evalue="5.90E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg22_1"
                     /protein_end="332"
                     /protein_start="310"
                     /score="37.5"
                     /tool="antismash"
                     /translation="YLGRIDHQVKIRGYRIEIGEIE"
     aSDomain        1292..1483
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_1_PCP.1"
                     /evalue="7.60E-23"
                     /label="ctg22_1_PCP.1"
                     /locus_tag="ctg22_1"
                     /protein_end="494"
                     /protein_start="430"
                     /score="72.4"
                     /tool="antismash"
                     /translation="ETKLAEIWKDILDIKQVGIQDNFFDIGGDSLKVLKLIQSIKERMR
                     TEISFQTVFNAQTIELLAL"
     aSDomain        1556..2182
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_1_Thioesterase.1"
                     /evalue="5.40E-25"
                     /label="ctg22_1_Thioesterase.1"
                     /locus_tag="ctg22_1"
                     /protein_end="727"
                     /protein_start="518"
                     /score="81.0"
                     /tool="antismash"
                     /translation="NVFCFPSRIGIGMTYIEMAYLLEGDYRIYITDFIHDHTNFDDMIR
                     EYAENIVQIQEQGPYVFLGYSGGGNIAFEVAKVMEKKGLEVSDIIMLDTTLWNAEVNKR
                     AMKMLSEVNREHTKVPEWMNTKYVQNKINKFTMYLEQLTNEGVLDSNIHNIVIDNSMTK
                     FKKEWANATTKDYIEYDGYGTHDEILQPEYIDKNVSIVKEILKNIN"
     CDS_motif       1718..1786
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg22_1_0004"
                     /evalue="1.20E-09"
                     /label="NRPS-te1"
                     /locus_tag="ctg22_1"
                     /protein_end="595"
                     /protein_start="572"
                     /score="30.6"
                     /tool="antismash"
                     /translation="QEQGPYVFLGYSGGGNIAFEVAK"
     CDS             2356..2631
                     /locus_tag="ctg22_2"
                     /transl_table=11
                     /translation="MIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSIKT
                     HNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG"
     CDS             2934..7235
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: -2.4; E-value: 36.0)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_3"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.9e-54, bitscore:
                     178.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQS
                     AESIQNKISSSLKKSFKKKEKTTFLIKFKDQANTEKAAKAAVKKAKSKKLSAAKTEYQK
                     RSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKVAQF
                     PEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDGTGTV
                     VASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGTHVTGT
                     MVGSEPDETNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGHPHPEMAP
                     DVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANPANYPESF
                     ATGATDINKKLADFSLQGPSPYDETKPEISAPGVNIRSSVPGQTYEDGWDGTSMAGPHV
                     SAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNAFDAVSAVTD
                     GLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTSVKLSYKLDQG
                     EWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSDIYDVTVKPSIT
                     AGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLTGNYANSANMNLV
                     MPPVKVPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGVYNGKTSSWTDEEI
                     DLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKKNKLGVEKPSGKQKK
                     KPVNPKKAKPSANTSVKHQNKAIQPQVLPLRAQVSVVETGKSTYSDQSTGQYTLKHKAG
                     DYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGTVINKTTGEPVKGASVY
                     VVEDAAVGPAMTNDKGEYTLEAYEGAYTIKVAAPGYYSDEFSVELKGDVTKETALKPFV
                     GYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGMLTGGLFRFWDTEFPDPGGT
                     EFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLSSKGIMVDRDFYLVYIQSKP
                     DPYSPGLAMDETGKNSGRNWQYIGGQWEPGDEADGNYMIRALVNYEAAVPEITSPTDKS
                     YTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGTFHAGIILNKGENELTATASTD
                     NGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETLTVKGAVSDDNLKDVKVNGKKAT
                     VADGSYSARILLENGRNEIKVIATDLAGNKTTKKTVIDVNFDKPVISGLIPGEDKNLKA
                     GESVKIAFSSAEDLDATFTIRMPLTNARASVQNATELPLREISPGRYEGYWTATSSIKA
                     KGAKVEVIVRDDYGNETRKTANGKLNINTEN"
     CDS             7402..8358
                     /locus_tag="ctg22_4"
                     /transl_table=11
                     /translation="MRQERKESDVKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRL
                     VGGAFIGSSIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFAT
                     FLMGGGIIGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDI
                     ETKNIQYEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAE
                     TMIIRNTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMIS
                     ADKCLIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS"
     CDS             8421..9140
                     /locus_tag="ctg22_5"
                     /transl_table=11
                     /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEEQ
                     VLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTFNP
                     EKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTDDDI
                     ITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQSYISR
                     LEKRIIKRLRKEFNKMV"
     CDS             9280..10062
                     /locus_tag="ctg22_6"
                     /transl_table=11
                     /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLVN
                     GNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGEIR
                     RYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFALDA
                     IQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMILRKR
                     FFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ"
     CDS             10210..11004
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 148.4; E-value:
                     4.5e-45)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_7"
                     /transl_table=11
                     /translation="MILQLDNVSLKRNGKWILRDIHWKVEEKENWVLYGLNGAGKTALL
                     NMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALSGA
                     YASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADPELL
                     ILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQGEVF
                     GSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA"
     CDS             11206..12486
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247:acetylornithine deacetylase (Score: 210.7;
                     E-value: 5.6e-64)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_8"
                     /transl_table=11
                     /translation="MDQQIDSLQKKVEEQKEELIQLAKTLISYQTPAPPARNTEGIQSW
                     IAGFLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWKHD
                     PFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREAGIELPGDLILQSVIGEEVGEAGT
                     LECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGGGTFG
                     ASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADECRLWI
                     TVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIFPALEVD
                     SGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHNAHSVNEK
                     VSIEQLVEYTKIILDFIISWCSRKKEQ"
     CDS             12569..12814
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGNG
                     KVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA"
     CDS             12977..13813
                     /locus_tag="ctg22_10"
                     /transl_table=11
                     /translation="MNTYHPFSLTTPSTLMIQDWVQTNQNNKKVIAGFTTKNGGVSQKP
                     FESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKGAR
                     EYHTALKATDGLYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIGREM
                     VKQWIEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAVNQTAKAQYQL
                     DLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGIKEA"
     CDS             13820..14512
                     /locus_tag="ctg22_11"
                     /transl_table=11
                     /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQEA
                     VDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNAVSYIHSLDRLSLA
                     KEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAPLTD
                     DQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGSSLVG
                     NETGGVQQ"
     CDS             14509..14964
                     /locus_tag="ctg22_12"
                     /transl_table=11
                     /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGNK
                     PAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKRIV
                     DFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW"
     CDS             14971..15243
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLASI
                     CEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF"
     CDS             15304..16077
                     /locus_tag="ctg22_14"
                     /transl_table=11
                     /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQVI
                     LSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEKSDFELQAFNVRYADKFVSVDHR
                     SLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKIDLSD
                     LNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPSYIVA
                     EGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK"
     CDS             16171..16665
                     /locus_tag="ctg22_15"
                     /transl_table=11
                     /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKTE
                     LEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADRII
                     NESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVFEEK
                     E"
     CDS             17007..19772
                     /locus_tag="ctg22_16"
                     /transl_table=11
                     /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERTK
                     DRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIETA
                     LTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEYEAQ
                     QIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDGKGVL
                     ENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASACGFDQY
                     EVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDFIIGQKY
                     GLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHSYPHDWRT
                     KKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDWCISRQRAW
                     GVPIPVFYAENGEPIITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFTHPGSPNGTF
                     TKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSLSTAVAVTGKA
                     PYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSVDYQADVRVSDA
                     ILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNTVAVEDLREVDQYMLIKLNKLIDKVKKA
                     YDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSMQTVFYETLLALVK
                     LSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEKFDRFMALRDDVLKA
                     LETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVSELTISEENEAPNDAQ
                     SFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEIVEKYYQK"
     CDS             19917..20291
                     /locus_tag="ctg22_17"
                     /transl_table=11
                     /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQKA
                     TLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQFE
                     KKTLPIWKSTDIEYGQALYE"
     CDS             20394..20858
                     /locus_tag="ctg22_18"
                     /transl_table=11
                     /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHRN
                     TGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFIDRA
                     VRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ"
     CDS             20860..21771
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1279:pseudouridine synthase (Score: 271.3; E-value:
                     1.6e-82)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_19"
                     /transl_table=11
                     /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVVN
                     GSAVKANYKIQPGDQVTVTVPEPEALDVLAEPLDLDIYYEDQDVLVVNKPRGMVVHPAP
                     GHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQLVN
                     KTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERFQDFT
                     LVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHPRTGEY
                     VEFEAPLPEDMAELIENLRKNG"
ORIGIN
        1 cgggggagcg tatgtaccaa ttgatccgga gtatccagaa gagcgaatcc attatatgtt
       61 agaagattca aaagcacact tattattaac ccaaagtcat ttgcgagatc gaatatcgtt
      121 cgctggaaag atattgtccc ttgatgaaga agacagctat gatgaagctg aatctaatct
      181 gaaatctatt gtggaaccac accatttggc atatgtaata tatacttcag gaacgactgg
      241 gaaaccaaaa ggagttatgg ttgagcatag agggttatgt aatttaacaa cacactttaa
      301 agaaaacttg catatgaacg agcatgaccg agtggtacag tttgcgagta tctcatttga
      361 cgcagctgtt tgggaagtat ttacttcctt attattaggg gctaaattat atatacctaa
      421 gaaattagaa attatagatc atcatttgtt tgttaaattt atgaacgata aaaaaattac
      481 gacggcgtta ttacctccaa cgtatataag atatttaact ccagagaatt tttcttcttt
      541 aaaaagatta attactggtg gatcagctat aacagtagat ttgatgacaa aatggaaaga
      601 aaatctattg tatctcaatg cttatggtcc tacagaggat tctatcataa caacggtgtg
      661 gaaagggtta gaagagaaca ttcaacctta tatagtacca attggtcgtc ccattcctaa
      721 tcataatgta tatatattaa acaccagtga tcaattacag cctgtaggag tcccaggaga
      781 attatgtatc agtggagttg gtctagctcg aggctactta aaccgcccgg atttaacggc
      841 cgaaaagttt gtcgatcatc cgtttatccc tggtgagaaa ttgtatcgaa caggagacct
      901 tgccagatgg ttaccggaag gtaacattga gtatttagga cggattgacc atcaagtgaa
      961 aatacgcgga taccggattg aaattggaga aattgaaaca gctttattga atatggaagc
     1021 tgtacaagaa gcaatcgtgg ttgcgcatga aaacgacaac ggagataaag cgttatgtgc
     1081 atactacgtt gcgagtgaat cttttgcggt cagtgagatg aaagagaaat tatctgtcca
     1141 aatgccaagc tacatgcttc catcttattt tattcaactg gagaaaatgc cgctgacatc
     1201 taacgggaaa attgaccgta aggaactccc tctgcctgat gaaaaaaata tccagacagg
     1261 ggttgagtat gtagcacctc gtacaccaat tgaaacaaag ttagctgaga tttggaagga
     1321 catacttgat ataaaacaag tgggaataca ggataacttc tttgatatag gaggtgattc
     1381 attaaaagta ttaaaactaa tacaatctat aaaagaacga atgaggactg aaatttcatt
     1441 tcaaacagta tttaatgctc aaaccattga attattagca ttggatctaa tgaatgggaa
     1501 tataaaatta gaagatgaaa caaagtttac accaataact catcgtggaa acgtcaatgt
     1561 gttttgcttc ccgtctcgca taggaattgg gatgacatat atagagatgg cttatttgtt
     1621 agagggagat tatagaatat atattacgga ctttattcat gatcacacaa attttgatga
     1681 tatgattcgt gaatatgcag agaatatagt tcaaatacaa gaacaaggtc catatgtatt
     1741 tctggggtat tctggaggag gaaatatagc atttgaagtt gcaaaggtaa tggaaaaaaa
     1801 aggattggaa gtgtcagata taataatgtt agatacaact ctttggaatg ccgaagtaaa
     1861 taaaagagca atgaaaatgc tatcagaagt taatcgtgaa catacaaagg ttccagaatg
     1921 gatgaatacg aaatatgtac aaaataaaat taataaattt acaatgtatt tggaacagct
     1981 aacgaatgaa ggagtattag attctaatat tcacaatatt gtaatagata attcaatgac
     2041 taaatttaaa aaggagtggg caaatgcaac aacaaaagat tatatagaat atgatggcta
     2101 tgggacacat gacgaaattt tgcaacctga atatatcgat aaaaatgttt caatagtcaa
     2161 agaaatatta aaaaatataa acaagtctgt tatgacatcg atttaaactg tttttttaat
     2221 tctaaaatac agagagtatt ttccgagaaa tatttttcct aataatgtga aataagaaat
     2281 taaattatgt caagaaattt ataataacag gtttttaatt cttttgtcgc ttcggcgtct
     2341 gatcaagacg taaacatgat tttcggttct gttattaatg aaaatctaaa agatgagatt
     2401 gtggtgacag tgattgcaac cggctttatc gaacaagaga aggacgtgac gaagcctcag
     2461 cgtccaagct taaatcaaag catcaaaaca cacaatcaaa gtgttccgaa gcgtgagcca
     2521 aaacgtgagg agcctcagca gcagaacaca gtaagccgtc atacttcaca gccggctgat
     2581 gatacgcttg acatcccgac attcttaaga aaccgtaata aacgcggcta aagtaaagga
     2641 caaaatcgtt ttcgattttg tccttttttg tttttctctt cacactttcc ttcttataaa
     2701 gtctttttcc ctattgcttc cttcgcttag taacaaaaca gataattaga cctatttatt
     2761 tttgtgacat ttctatcatt ttcatatata tggaaattga atgacatgaa acgacaatat
     2821 ctgtaattca gattgtctac agttaatata cagcgatgtt ctgacaaacc attcattatt
     2881 aaaaggaggg acgacacttt ttttaaaaag catgttgaaa aagggggatg aaaatgaaga
     2941 aaaaaacgaa aaacagactc atcagctctg ttttaagtac agttgtcatc agttcactgc
     3001 tgtttccggg agcagccggg gccagcagta aagtcacctc accttctgtt aaaaaggagc
     3061 ttcaatctgc ggaatccatt caaaacaaga tttcgagttc attaaagaaa agctttaaaa
     3121 agaaagaaaa gacgactttt ctgattaaat ttaaagatca ggctaacaca gaaaaagcgg
     3181 caaaagcggc tgttaaaaaa gcgaaatcga agaagctgtc tgccgctaag acggaatatc
     3241 aaaagcgttc tgctgttgtg tcatctttaa aagtcacagc cgatgaatcc cagcaagatg
     3301 tcctaaaata cttgaacacc cagaaagata aaggaaatgc agaccaaatt cattcttatt
     3361 atgtggtgaa cgggattgct gttcatgcct caaaagaggt tatggaaaaa gtggcgcagt
     3421 ttcccgaagt ggaaaaggtg cttcctaatg agaaacggca gctttttaag tcatcctccc
     3481 catttaatat gaaaaaagca cagaaagcta ttaaagcaac tgacggtgtg gaatggaatg
     3541 tagaccaaat cgatgcccca aaagcttggg cacttggata tgatggaact ggcacggttg
     3601 ttgcgtccat tgataccggt gtggaatgga atcatccggc attaaaagag aaatatcgcg
     3661 gatataatcc ggaaaatcct aatgagcctg aaaatgaaat gaactggtat gatgccgtag
     3721 caggagaggc aagcccttat gatgatttgg ctcatggaac ccatgtgaca ggcacgatgg
     3781 tgggctctga acctgatgaa acaaatcaaa tcggtgtagc gcctggcgca aaatggattg
     3841 ctgttaaagc gttctctgaa gatggcggca ctgatgctga cattttggaa gctggtgaat
     3901 gggttttagc accaaaggac gcggaaggac atccccaccc ggaaatggct cctgatgttg
     3961 tcaataactc atggggaggg ggctctggac ttgatgaatg gtacagagac atggtcaatg
     4021 cctggcgtgc ggccgatatt ttcccagagt tttcagcggg gaatacggat ctctttattc
     4081 ccggcgggcc tggttctatc gcaaatccgg caaactatcc agaatcgttt gcaactggag
     4141 cgactgatat caataaaaag ctcgctgact tttctcttca agggccatct ccatatgatg
     4201 aaacaaagcc ggaaatatct gcaccgggcg taaatattcg ttcatccgtt cccggtcaga
     4261 catatgagga tggatgggac ggcacatcaa tggcagggcc gcatgtatcc gctgttgctg
     4321 cactgctaaa acaggcgaat gcctcacttt ctgttgatga gatggaggat atattaacca
     4381 gcacggctga accactcacg gattcaacat ttcctgattc accgaataac ggatatggcc
     4441 atggtctggt gaatgctttt gatgctgtat ccgctgttac agatggttta gggaaagcgg
     4501 aaggacaagt ttctgtagag ggggatgacc aagagcctcc tgtctatcag catgagaaag
     4561 taactgaagc ttatgaaggc ggcagcctgc cactgacttt gacagctgaa gacaatgtga
     4621 gtgtgacatc tgtaaagctg tcctacaagc ttgatcaagg tgaatggaca gaaataacgg
     4681 ctaaacgaat cagcggtgat catctaaaag gaacgtatca ggcagagatc ccagatataa
     4741 aaggaactaa actaagctat aagtggatga ttcacgattt tggcggtcat gtcgtttcgt
     4801 ctgacatata cgatgtaaca gtgaaaccaa gcatcacggc gggatataag caggactttg
     4861 aaactgcacc cggcggctgg gttgcgagcg gaacaaataa taactgggaa tggggagttc
     4921 cgtcaactgg cccaaataca gcagcatccg gagaaaaagt atatggaacg aatttgacag
     4981 gaaattatgc caactcagca aacatgaacc ttgttatgcc tcctgttaaa gtacctgatt
     5041 caggaagttt gttccttcaa tttaaaagct ggcacaattt agaggatgat tttgattacg
     5101 gctacgtttt tgttcttccg gaaggtgaaa agaattggga gcaggctggt gtctataacg
     5161 gaaagacatc aagctggacg gacgaagaaa ttgatttatc ggcttataaa ggccaaaaca
     5221 ttcaagtgat gtttaacctt caatctgatg aaagcattgc aaaagagggc tggtatattg
     5281 atgatgtagt gctttctgac aaatcagccg gaaaaacagt caaaaagaat aagctgggcg
     5341 tcgaaaagcc gtctggaaag caaaagaaaa agccagtaaa tccgaaaaag gctaagccat
     5401 ctgcaaacac atcggtaaaa catcagaaca aggctataca gcctcaagtt ttgccgctca
     5461 gggcacaagt cagtgtagtg gaaacaggaa aatcaacata ttcagatcaa tccacagggc
     5521 agtacacgct gaagcacaaa gcgggagact atacgcttat ggcagaagca tatggttatc
     5581 agtcgaaaac acaaaaagta tctttaaaga cggatcagac gacacaagct aattttacgt
     5641 tagaagagat gaagaagggc acattaaaag gcacggtcat caataaaacg acaggagagc
     5701 cggtaaaagg cgcttccgtt tatgttgtag aggatgctgc ggtgggaccg gctatgacaa
     5761 acgacaaagg tgaatatacg ctggaggcct atgaaggcgc ttatacgatt aaagtcgctg
     5821 caccgggtta ttacagtgat gaattttccg ttgagttaaa aggtgatgtt acaaaagaaa
     5881 ctgcattgaa gcctttcgtc ggttatccgg gtgaaattgc atatgatgac ggaacagcgg
     5941 agaatgccaa ttcctatttt gctgccggta acggatgggc ggtaaaaatg acgctcgctg
     6001 acggcaagga caaaggcatg cttacaggag ggctgttcag attctgggat acagagttcc
     6061 cagatccggg cggcacagag tttaaggttg aggtatacga tgccacagga aaagacggag
     6121 caccgggcaa gaaaattgca gggccattta acgctgaagc tcttcgcaat ggcgagtgga
     6181 ctaaggtaga tctcagttca aaagggatta tggtcgatag agacttttat ctcgtatata
     6241 tccagtcaaa acctgacccg tattcacctg gactggcaat ggatgaaacc ggcaagaatt
     6301 ccggccgcaa ctggcagtat ataggtggac aatgggagcc gggtgacgaa gcagacggca
     6361 actatatgat tcgcgcatta gttaattatg aagctgctgt acctgagatt acttcaccga
     6421 cagacaaatc atacacaaat aaggatagcg tcactgtaaa aggaaacgct tctcctggca
     6481 caacggtaca catttataat ggagagaaag aagcaggaga aacgaaagct gctgcggatg
     6541 gcacgttcca tgcaggcatc atactcaaca agggtgaaaa tgagctgacg gcaactgcat
     6601 caactgacaa cggaacaaca gatgcctcca gcccaatcac ggtcacgctt gatcaagaaa
     6661 agcctgaatt aacactggac aatccaaagg atggcgggaa aacaaataaa gaaacgctga
     6721 ctgtcaaagg ggctgtatcc gatgacaatc tgaaagacgt caaggtgaat ggcaaaaaag
     6781 caacagtagc tgatggttca tactcagccc gtattctttt ggaaaatgga agaaatgaaa
     6841 tcaaggtaat tgctacagac ttggcaggca acaaaacgac gaaaaagaca gtcattgatg
     6901 tgaactttga caagcctgtc atttccggct taattccggg agaggataaa aacttaaaag
     6961 ccggtgaatc tgtgaaaatc gctttctcaa gcgctgagga tttagatgca acgtttacca
     7021 ttcgtatgcc gctgacgaat gcaagagcga gtgtgcaaaa tgccaccgaa ctcccgttaa
     7081 gagaaatctc tccggggaga tatgaaggct attggactgc cacttcttct attaaagcaa
     7141 aaggagcaaa agtagaagtg atcgtccgag atgattatgg aaatgaaaca agaaaaactg
     7201 cgaatggaaa acttaatatc aacacagaaa attaagtgga aaaaagctgc cgtcattggc
     7261 agcttttttt atatcctctc attatacttc ctcgacaaat taagcagatt tccctgaaaa
     7321 attgtatttt cctctcaaca ttaattgaca gactttccca cagagcttgc tttatactta
     7381 tgaagcaaga aggggaacag cgtgaggcaa gaaagaaagg agtcagatgt gaaaatctat
     7441 ttagatgtca tttggctgtt aaacttttgt tttgatgcac ttttgctttt gctcacggca
     7501 tttattttaa aacggcatgt aaaaaaaaga agactggtag gcggagcgtt catcggttcc
     7561 agtattgtcc ttttgatgtt tactcctttt tcgccgattg ttgaacatcc ggctgggaag
     7621 ctagcttttt cagttgtgat tgtggtggtg acatttggct ttaaaagatt tcggtttttc
     7681 tttcaaaatt tgttttcctt ttattttgcc acttttttaa tggggggagg aattatcgga
     7741 gcccattctt tgctgcagtc aaattctatt gttcaaaacg gtgtcatgat taccaatcaa
     7801 acagggtttg gagacccgat cagctggttg tttattgttg gtggctttcc agcattatgg
     7861 tttttttcta aaagaagaat tgaagatatt gaaacaaaaa acattcaata tgaggaacga
     7921 gtcagcgtgc aggcagattt gggcagccaa acacttcatg tcagaggcct gattgattcc
     7981 ggtaatcagc tgtacgatcc tcttacaaaa acaccggtaa tgatcattta cattgataaa
     8041 ctggagccga ttttcggaac agccgaaacg atgatcattc gaaatacaga cccattggaa
     8101 gccatcgaac agctcgatga ttcctttcgc tttttagata aaatgaggtt gattccatac
     8161 aggggagttg gtcagcaaaa tcaattttta ttatgcgtta aaccggatca cgtaacgatt
     8221 atgacaaaag aagaaatgat ttctgcagat aaatgtttaa tcggcatcag cacaacaaag
     8281 ctgtcggcag atggagagtt tgacgcgatt attcatccaa aaatgctttc gggcaaggct
     8341 gtcaaacatg tttcataatg ttcgcaaatg tccgttactt atcatactca aacggcgtga
     8401 catttagaag ggagaggaag atgaaaaaac tgaaattacg gttgacgcac ctctggtata
     8461 agctactgat gaaacttggg ctgaaaagtg atgaagtcta ttacataggc gggagtgaag
     8521 ccctgccgcc tccattatct aaagatgagg agcaggtttt gttaatgaag ctcccaaacg
     8581 gcgatcaggc ggcgcgcgcc attctaattg aacgcaattt gcgtctagtc gtatatatcg
     8641 cccgtaaatt tgaaaatacg ggaattaata tagaggattt aatcagcatc ggtaccatcg
     8701 gtctaatcaa agctgtgaat acattcaatc cagaaaagaa aatcaagctt gctacctatg
     8761 cctcccggtg tatagaaaat gaaatcctga tgtatttaag aagaaataac aaaatccgtt
     8821 cagaggtttc ctttgatgaa ccgcttaata ttgattggga cggcaatgag cttttgcttt
     8881 ctgatgtgct cggcactgac gatgacatca tcactaaaga catagaagct aacgtcgata
     8941 aaaagctttt gaaaaaagcg cttgaacagc ttaatgagag agaaaagcaa atcatggagc
     9001 tgcggtttgg gcttgtcggt gaagaagaaa aaacccaaaa ggatgtagcg gatatgatgg
     9061 ggatttctca gtcttatatt tcgcggcttg agaaaagaat tataaaaaga ttgagaaaag
     9121 agttcaacaa aatggtgtaa aaaattttat ggttagaacc ccttgatttt acagggattt
     9181 cctgatttcg gcagtttttc ggtctgagtg cagtgcatat ttttcccacc caaggagata
     9241 cttaacgttg tacagcagct cctgtaggga gggaaaaaag tgtcgagaaa taaagtcgaa
     9301 atctgcgggg tggatacctc caaattacca gtactcaaga atgaagagat gagaaagctg
     9361 tttaggcagc tgcaggatga aggcgatgat tcagcaagag aaaagcttgt aaacgggaac
     9421 ttgcgtcttg tcttaagtgt cattcaacga tttaataaca gaggggagta tgttgatgac
     9481 ttatttcaag tcggctgcat cggactaatg aaatccattg ataattttga cctaagccac
     9541 aatgttaagt tttcaacata cgctgtacct atgattatcg gagagatccg caggtattta
     9601 cgcgataata acccgatccg tgtctcaaga tcactccggg acatcgctta caaggcgctt
     9661 caggtaagag agcggttaat cagtgagaca agcaaggagc cgactgcaga agacatcgca
     9721 aaagttcttg aagtaccgca tgaggaaatt gtatttgcgc ttgatgccat ccaggatccg
     9781 gtttctctat ttgaaccgat ctataacgac ggcggagacc cgatctatgt gatggaccaa
     9841 atcagtgatg agcgtaatac agattcacaa tggattgaag agctggcttt aaaagagggc
     9901 atgagaaggc tgaatgatag ggaaaaaatg attttgagaa agcgattctt ccaagggaaa
     9961 acccaaatgg aagtcgccga ggaaatcgga atttctcaag cgcaggtgtc cagacttgaa
    10021 aaagcggcta tcaaacaaat gaataaaaat attcatcaat aatgaaaagc ctttaaaacg
    10081 atgttgtttt aaaggctttt ctattgatta cggatggttt acgttttgga aaaagtaagg
    10141 tatcctagtt cgtacaaagt tttatgaaaa ttaaaacaat tacaaaaggc aataaagagg
    10201 aggaccacga tgattttgca gcttgacaat gtctcactaa aacggaatgg gaaatggata
    10261 ctgagagata ttcattggaa ggtggaagaa aaggaaaatt gggtgcttta cggcctaaat
    10321 ggcgccggga agacagcgct gttaaatatg ctttgctcat attattttcc aacatcaggc
    10381 gagatgcagg tgcttggcca tgaatttggc aaaacagagc ttggggaaaa gctcagacgt
    10441 aaaattggcc tcgtctcagc agctcttcag caaaaattgt atccggcaga ttcagccttt
    10501 gaaattgctt tgagcggagc ttacgcttcg attgggttat atgaaacgcc aagtaaggaa
    10561 accagggaaa aagcgatagg tttgttagag gacttgggag caattgaata tgccgatcgc
    10621 cgctatgaaa ccctttctca aggggaaaaa caaagagcgt tgattgctag agcactaatg
    10681 gccgatccgg agttgctgat actggatgaa ccagtcacag gactggattt tattgcccgg
    10741 gaaaagctgt tagatacgat tacatacatt gcaaacaaag aaaatgcacc atctatcctt
    10801 tatgtgactc atcatgctga agagattttg cctgtctttg ataaagccct tttattaaaa
    10861 cagggagagg tctttggatc cggagaaata aaggaaatgc ttactgatca aatactttcc
    10921 gctttttttg atacgccaat ccatgtatta tggaatcagg atcggccgtt tttaactaga
    10981 gctgagccga taacgaatgc ctgacaaata tatatagatt catcctaggg gtgctttgcg
    11041 aagctgagag agactttgtc tcaacccttt tgacctgatc tggatcatgc cagcggaggg
    11101 aagcggtgaa aagcggagta catcggactc cgtttgtttt tattaagccg tttcatcaca
    11161 tttgaaacgg cttttttgat tttaaagaat aggagcggat ttacattgga tcaacaaata
    11221 gactctttgc aaaaaaaagt ggaagaacaa aaggaggagc ttattcagct tgctaaaaca
    11281 ctgatttctt atcaaacacc cgctccgcct gcaagaaata cagagggcat tcagtcatgg
    11341 attgcgggat ttttaaatga attgggattc tcgatcgaca aatgggatgt gtaccctgga
    11401 gatcccaatg ttgtcggcaa gctaaaggga acagattcag cagattatta cagcctgatt
    11461 atcaatggcc atgtagatgt ggcagaggta aaagaggatg aagaatggaa gcacgatccg
    11521 tttcatccca ttgaaaaaaa cggtctctta atcgggcgag gcgcttccga tatgaagggc
    11581 ggaatggctt gtgtgctgtt tgctgtcaaa ttaattcgtg aagccggcat tgagcttcca
    11641 ggtgatctga ttctgcaatc ggttattggg gaggaagttg gagaggccgg cacacttgaa
    11701 tgctgcaaga ggggctacca cgctgatttt gcaattgtcg cggatacgag cgatatgcat
    11761 attcaaggcc aaggcggtgt cattacaggc tggatcgaaa tcaaaagcag tcaaacattt
    11821 catgatggaa cgagacggaa tatgattcac gcaggcggag gaacattcgg agcaagcgca
    11881 attgaaaaaa tggcgaaaat cattgcgggg ctcggtgaac ttgagcgcca ctggtccatt
    11941 atgaaaagtt atcccggttt taaaccaggc acaaatacga ttaatccggc agttatagaa
    12001 ggcggcagac atgcggcttt tatagcggac gaatgccggc tgtggatcac agtccatttt
    12061 tatccaaatg aaacccatga ccaagtggca gcggaaatag aagattacgt caatcggctg
    12121 agtgacagtg atatttggct tagggaaaac cgccctgtat tcaagtgggg aggctcatct
    12181 atgatagaag acagaggaga aatttttccg gcattggaag ttgactctgg ccacccaggc
    12241 gtcttagcgc taactgcctc tcatcagaaa gtgaaacggg agtgtccaat tattgacgtt
    12301 tctcaatcag ttacagatgg cggatggctg tatgatgccg gtattccatg cgtaatatac
    12361 ggtcctggag atctgcacaa tgcacactct gtgaacgaga aggtatcgat tgagcagcta
    12421 gtagagtata caaaaattat actcgatttt atcatcagct ggtgcagccg gaaaaaagaa
    12481 caatgacatg aaaatttctt cttgctgaca aggttcagcc tgcccgttca tatacttgaa
    12541 caaaaggacg gaaaaaggac gtgatggaat gatcagcatt tcagaatttc aggtaaagga
    12601 tgtcgtcaat gtctcaaacg gaaaaaagct ggggagtatt ggtgatattg atatcaatgt
    12661 gaccactgga aaaattcagg cgatcatact cggaggaaat gggaaagttc tcggattttt
    12721 tggaaaagaa gaggaattgg tcattccatg gcgaaatata gtaaaaatcg gggaagatgt
    12781 aatcttagtc cgattaagtg aaccacatgc ataaacctgc ttgtctgccg cagattggca
    12841 aatgccggaa gtctagattc ttccggcaca tttcatttag aaatatgcaa atcggcgctc
    12901 aacgaatgca gtaagatgtg gtaaaataag tgggaaattc cgctttttta aatgtttgtc
    12961 gaaaggttgg atcatcatga atacatatca cccattcagt cttaccacac cctcgacact
    13021 catgatacaa gactgggttc aaacgaatca aaacaacaaa aaagtcattg ccggatttac
    13081 gacaaaaaac ggcggtgtca gccaaaagcc ttttgaatcg ttaaatacag gattgcacgt
    13141 tcatgacaaa gatgcagatg tagttaaaaa tcgtgaatat attgccgata tgtttaatac
    13201 tgatttgcag tcttgggtat tcgctgatca gacacatgat aatcgcgttc agaaagtgac
    13261 gcagagggat aggggaaaag gcgcccgtga gtatcacacg gctctaaaag caacggacgg
    13321 gctatataca aatgaaaaaa atgtattttt agcattatgc tttgctgatt gtgtgcctct
    13381 tttcttttat gatccggtta agtcgcttgt cggagtcgcc catgccgggt ggaaaggcac
    13441 cgtcaaacag attggcagag aaatggtgaa gcaatggata gagaaggaag gttcaaatcc
    13501 ctcagatatt tacgctgtta ttggcccgtc tatcagcggt gcatgctata cggtagacga
    13561 ccgcgtcatg gatgctgtcc gcgcattgcc ggtttcagca gaccttgccg ttaatcagac
    13621 ggcaaaggca caatatcagc ttgatctgaa agagctgaac cgtcttatac tgatggacag
    13681 cggtttggca agtgaacaaa tttctgtcag cggtttatgc acggaaagcg agccgtctct
    13741 tttctattct caccgccgcg atcaggggaa aactggacgg atgatgtcct ttatcggaat
    13801 aaaggaggca taaaagatct tgcgtgttgt tgataattta cgacatataa acgaacgaat
    13861 aaacgaagca tgtaacagat cgggccgcag ctccgatgaa gttacggtta ttgcagtcac
    13921 taaatatgta tcgcctgaaa gagcacagga ggcagtagat gctggcatca cctgcctcgg
    13981 agagaatcgg gatgcggaac tgctccgcaa acaggaattg atgaaaggga atccggaatg
    14041 gcattttatc ggcagtctgc aatcaagaaa agcaaaatct gtcgtcaatg cggtttccta
    14101 tatccattcc ctagaccggc tctcattagc gaaagaaatt gaaaaacggg ctgaaggtac
    14161 tgtacgatgc tttgtgcagg tcaatacctc tcttgagcct tctaaacacg gcatgaaaaa
    14221 agaagaagtc attccattca tacaggagct ttccggtttc gaacatatcc ttgttgccgg
    14281 gctgatgaca atggctccgc tgactgatga tcaagatcag atcagaagct gtttcaggtc
    14341 gctgagagaa ctccgtgacc aggttcagaa gctgaaccag ccgaacgctc cgtgtactga
    14401 actgtcgatg ggcatgtcaa atgattttga aattgcaatt gaagaaggag ctacttatat
    14461 tagaatcggc tcatcgttag tcggaaatga aacagggggt gtacagcaat gagtatgaaa
    14521 aataaactga aaaacttttt ctcaatggaa gatgaagaat acgaatatga atatattgag
    14581 acagagcggg aatctcatga ggagcatgag caaaaagaaa agccggctta caacgggaat
    14641 aaacctgcgg gcaaacagaa tgtagtgagc ttgcaaagtg ttcagaaatc ctctaaagtg
    14701 gtgttgagtg agccgcgcgt ttatgcggag gcgcaggaaa tagccgacca tttgaagaac
    14761 cggcgggcag ttgtcgtcaa tcttcagcgg atacagcatg accaggcgaa gcggattgtt
    14821 gactttttaa gcggaaccgt ttatgccatt ggcggcgata ttcaaagaat cggctcagat
    14881 attttcctct gcacgcctga caacgtagat gtatcaggca caatttctga gctcatatct
    14941 gaagacgaac atcagaggtg gtaaagcgag atgatccttt atcaagtttt ttcggtttta
    15001 agcttattaa tcacaatata ctcatttgcc ctgatcatat atatttttat gtcatgggtg
    15061 ccgagtacga gggaaacagc agtcgggcgt tttttggctt cgatttgtga accatatctc
    15121 gaaccattca gaaaaatcat tcctccgatt gcaatgctgg atatttcacc aatcgtagca
    15181 atacttgtgc ttcggtttgc gacaaccggc ttgtgggggc tttatcgcat gattgcgttt
    15241 taatgtgaca gtttgatagg ggcttggcag cagccaagcc tctttacata gaagggaaag
    15301 acgatgagcg atatatatca gcacttcaga aaagacgagc gggcctttat tgatcaggcg
    15361 ctcgaatgga aaagaattgt ccaggagcag taccggatga agctgaccga ctttttagac
    15421 ccccgagagc aggtcatcct ctctgctgtt acgggacagg ctgacgtcgg gcttgctttt
    15481 tccggcggtt atgacagagc ggagcggaaa cgggcgattc tgtttccaga gtacattact
    15541 ccggaaaaat cggattttga attgcaggcg tttaacgtcc gttatgctga caagtttgtc
    15601 tcagtagatc atcgttctct gcttggtgca ttaatgggca taggattaaa gcggcaaaaa
    15661 ttcggtgaca tcgtgttttc tgagacagca gtgcaattga ttgtctcagc cgataccgct
    15721 gattttgtgg ctgcacagct gacccaagca ggcaaagcgg cggtcagcct agagaaaatc
    15781 gacttgtcag accttaacat tccagcagtt gatgtcgaaa taagagatga cacggtttct
    15841 tctttaaggc ttgacgccgt ctgcgcctct atgagcaggc aatcccgcca gaaatcacag
    15901 acgcttgtga aaaacggcct tgtgaaagtg aactggaagg tggttgaaga tccttcatac
    15961 atagtcgcgg aaggggacat gctgtcaatc agaggttttg gccggtgcag cttaacaaaa
    16021 atcgaaggga aaaccaaaaa agacaaatgg agagttacgt ttgaacgaca aaaatagtcg
    16081 gtttttcagt ttttttctcc atctgtgcga aatttgtttt ataatgtgaa ctagataacc
    16141 gtactgaaat gtaaaaatgg aggtggcatc atgccattaa cgccaaatga tattcacaac
    16201 aagacgttta caaaaagttt tcgcggatat gatgaagatg aagtaaatga attcctagcc
    16261 caagtcagaa aagattacga aattgttctc cgcaagaaaa ctgagcttga agcgaaagtc
    16321 aatgagctag atgaaagaat cggacacttt gccaatattg aggaaacatt gaataaatca
    16381 attttagttg ctcaagaagc ggctgaagac gtaaaacgca attctcaaaa agaagcaaag
    16441 ctgatcgttc gggaagcgga gaaaaacgct gatcgcatta tcaacgaatc gttatcaaaa
    16501 tcaagaaaaa ttgcaatgga aattgaagag ctgaaaaaac agtctaaagt gttcagaaca
    16561 cgtttccaaa tgctgattga agctcagctt gatcttctga aaaatgacga ttgggatcat
    16621 ctccttgagt atgaagtcga cgctgtattt gaggaaaagg aataaattct ttgattatct
    16681 tgacattttc ttagcttgtc gaatataata cgttcataaa ttcagatgaa aaaacggttg
    16741 aaagggacag tcatgtttcc ttcaggcctt catagcgacc cggagatggt gagagtccgg
    16801 gatggccgga atcatgtaga tcagcccttt agtttccttg ctgaactcac agtaggttag
    16861 gacgttcatc acgttacgat gctcaagagg aaaaagtgta tgcttgcttt ttctaaaagg
    16921 gtggtaccgc gagataagct ttctcgtccc ttatgggatg agagggcttt ttttattttc
    16981 tgaaaaaatg cagtggagga atgaaaatgg attttaaaga cacgctctta atgccgaaaa
    17041 cagatttccc gatgcgtgga aatttgccaa accgtgagcc tgacattcaa aaaaaatggg
    17101 aggaagaaga tatctaccgt cttgttcagg aacggacgaa agaccgcccg aaatttgttt
    17161 tacatgacgg acctccgtat gcaaacggcg acatccatat gggccatgca cttaacaaga
    17221 ttttgaaaga cttcattgtc cgctataaat caatgagcgg ctacaacgca ccgtatgtgc
    17281 cgggctggga tacacacgga ttgccaattg aaacagctct gacaaaaaac aaaaaggtca
    17341 accgcaaaga aatgtcagta gcggaattcc gcaaactatg cgaagagtac gcttggaagc
    17401 aaatcgaggg acagcgtgag caattcaaac gtcttggtgt ccgcggtgac tgggaaaacc
    17461 catacgtgac attaaaaccg gaatacgaag cgcaacaaat ccgcgtattt ggtgaaatgg
    17521 caaaacgagg ctacatttac aaaggcctta aaccggttaa ctggtcacct tcaagtgagt
    17581 ctgctctggc tgaagccgag atcgaatatc aagacaaacg ttcagcatct atttacgtcg
    17641 cttttggtgt aaaagacgga aaaggcgttc ttgaaaacgg cgagcgcatc attatttgga
    17701 caacaacgcc ttggacaatt ccggcgaacc tcggaatctc agtgcaccct gatcttgagt
    17761 acagcgtgat tgcagtaggt gaagaccgct ttgtcgtagc aagtgcctta gtcgaaaatg
    17821 ttgcatcggc atgcggattt gatcagtatg aagtgacaag aacggtcaaa ggaaaagacc
    17881 ttgagaacat tatcgctgaa cacccgctat atggcagaga ctctctcgtt atgcttggtg
    17941 aacacgtaac aactgatgcc ggaacaggct gtgttcatac agcgcctgga catggggaag
    18001 atgactttat catcggccaa aaatacggtt tagatgtgct ttgcccggtc gatgaaaaag
    18061 gtgtaatgac aagcgaagct cctggctttg aaggcatgtt ctatgatgat gcaaacaaag
    18121 cgatcacaca gcagcttgat gaaaaaggcg cacttgtgaa gcttgaattc attactcatt
    18181 cttatccgca tgattggaga acaaaaaaac caaccatttt cagagcgaca gcgcaatggt
    18241 ttgcgtctat taaagatttc agatcagacc tgctggatgc cattaaagaa accaaatggg
    18301 ttcctgaatg gggcgagcag cgtttgcaca acatggttcg ggaccgcgga gactggtgta
    18361 tttccagaca gcgtgcgtgg ggtgtgccga ttccggtatt ttacgctgaa aacggagaac
    18421 cgattattac agatgaaacc attgaacatg tttctgaatt gttcagacag catggatcaa
    18481 acatttggtt tgaaaaagaa gcaaaggatc ttcttccgga aggctttacg catcctggca
    18541 gcccgaacgg cacatttaca aaagaacagg atatcatgga tgtttggttt gattcaggct
    18601 cttcacatca agcagtgctt gaagaacgtg atgacctcgt tcgcccggct gatctatacc
    18661 tagagggatc tgaccaatat cgcggctggt ttaactcttc tctttctaca gcagtagccg
    18721 taacagggaa agcgccgtat aaaggtgtgc tcagccatgg gttcgcactg gatggagaag
    18781 gacgtaagat gagtaaatca atcggtaacg ttgttgttcc ggctaaagtc atgaaacagc
    18841 ttggtgccga catcttaaga ttatgggtat cttcagtgga ttatcaggcg gacgttcgcg
    18901 tgtctgacgc cattctgaag caggttgcgg aagtatatcg taaaatccgc aacacgttcc
    18961 gtttccttca cggcaacctt ttcgattttg atccaaaaac aaatacggtg gctgtcgaag
    19021 atcttcgcga agtggatcag tatatgctga ttaagctgaa caagctgatt gataaagtga
    19081 aaaaagcata tgatgagtac gaatttgcgg ttgtgtatca cagcattcat aatttctgca
    19141 caatcgaatt gagctcattc taccttgatt ttgcaaaaga tattgtctac atcgagcatg
    19201 cggatcatcc ggatagacgc agcatgcaga cagtattcta cgaaacgctt cttgcattag
    19261 tgaagctttc agcgcctatc cttccacata cggcagacga attgtggtct catttaacat
    19321 ttgttgaaga gcagagcgtt cagttgaccg atatgccgga aacaatcacg gttccaaaca
    19381 gtgaagcgac tgaagaaaaa tttgaccgct ttatggctct tcgtgatgac gtgttaaaag
    19441 cattagaaac tgcgcgaaat gaaaaaatta tcggtaaatc tttggaagca aacctgaaat
    19501 tgtatccaaa caaagaaaac aaggagctct tggcttccat aaaagaaaac ctttctcagc
    19561 tgtttattgt gtctgaactg acaatcagcg aagaaaatga agcgccgaac gatgcgcaaa
    19621 gctttgcgac aggtaaaatc gctgtcgaga aagcggaagg cgaaatgtgt gagagatctc
    19681 gtgtgatttc aaaagatgta ggggcaaatc cgaaatatcc tacactttca ttacgcaacg
    19741 ctgaaatcgt tgaaaaatac tatcaaaaat aatgcaaaag agcccggcgt aaaagccggg
    19801 ctttttttgt gccaagagtg acatccttta gaacgacagg aaaaatctta tgggctttag
    19861 atcatcattc acaggcaaca ataaagatac tacgttaaga gcaggagttg tgaagaatga
    19921 atgatcaact gaccgcaatt tatacggaac ttcttctgat gaaagaagaa ttacagtcca
    19981 gattatttga gtattcttgc tttcaggttt ctacaagccc gcaagcagca atcaatcaaa
    20041 aacaaaaagc aactctgatc tatcatatta aagaagaact tcaagacgtt ctccttgcat
    20101 tgtccaaaat cgaaaacggc acattcggat actgtgaaga aaccggggct cccattcctc
    20161 ttgcaaagct ggcagtgctg ccgacggccc gaacagcaaa cgattttctt tattctgtcc
    20221 aatttgagaa aaaaacgctt ccgatatgga aatcaacgga tatcgaatat ggtcaggcac
    20281 tgtatgaata acagtgtctg gccggttatt atgcctgata tttctttact ccagtgcttt
    20341 ttattgataa aatgcataat ggattaaagt aaccgtaaac tggaggaacg tttgtgctgt
    20401 attatatgat tgcactactt attattgcag ccgatcaatt gacaaaatgg ctagttgtta
    20461 agaacatgga acttggccaa agcattccga tcattgatca ggtattctat atcacctccc
    20521 atcgcaatac gggtgctgca tgggggatat tagcgggtca gatgtggttt ttctacctca
    20581 taacaaccgc tgttattatt ggtattgttt attacataca gcgttataca aaaggacaaa
    20641 ggcttcttgg cgttgccctc ggacttatgc ttggcggtgc catcggcaac tttatcgatc
    20701 gggctgtcag acaggaagtt gtggatttta tccatgttat tattgtcaat tacaattacc
    20761 cgatatttaa catcgcggac tcttcactat gtgtcggcgt aatgctttta tttatacaaa
    20821 tgctgttgga cagcgggaaa aagaaaaagg agcaatagca tgaatcaaat tgatataacc
    20881 gcttcagaag aacaaaaaag tgagcggatt gataaatttt tggcatcgac tgagaatgat
    20941 tggtcaagaa cccaggttca gcaatgggta aaagacggac aggttgtcgt gaacggaagc
    21001 gcggtgaaag cgaattataa aattcagccg ggtgatcagg tgaccgtcac tgtacccgaa
    21061 ccggaagcgc tcgacgtcct agcagagcct ctggatctgg atatttatta tgaggaccag
    21121 gatgtgctgg tcgtcaacaa acctcgcgga atggttgttc acccagcacc cgggcatctt
    21181 acgggcacac ttgtaaacgg ccttatggct cattgcacag acctttccgg aataaatggc
    21241 gtgatgcgtc cgggtattgt tcacagaatc gataaggaca cgtccggttt attaatggtg
    21301 gcgaaaaatg atatggcgca cgagtcactt gtaaaccaat tggtcaacaa aacggtcacg
    21361 cggaaatata cggcagttgt ccacgggctt atttctcacg atgatggcac aattgacgcg
    21421 ccgatcggac gagataagaa agaccgtcaa agcatgactg tgacacgtga tggcaaaaac
    21481 gctgtcactc attttcatgt actagagcgt tttcaggatt ttacgttagt ggaatgccag
    21541 cttgaaacag ggagaaccca tcaaattcgt gttcatatga aatatatcgg attcccatta
    21601 gcaggcgatc cgaaatacgg cccaagaaaa acaatcgact ttaatggcca agcgcttcac
    21661 gcgggagttt taggttttga ccatccacga acaggagaat atgtcgaatt tgaagcgccg
    21721 cttcccgagg atatggcaga attaatcgaa aacctcagaa aaaacggttg acagagggtt
    21781 tcttttctga aataataaac gaagctgaat agattcttta aaacagtcca gagaggctga
    21841 gaaggataac ggatagacgg gatgcgtgta taggcgcgca ccttgtccta aaacccctct
    21901 atgctctggc aggaggggtt ttttcttcta tatgaactgt gaggtgtcac acattgaatc
    21961 aaaaagctgt cattctcgac gaacaggcaa tcagacgggc gctgaccagg attgctcacg
    22021 aaatgatcga acgcaataaa ggaatgaata actgcattct tgtcggaatt aagacaagag
    22081 ggatttacct ggcaaaacgc cttgcggaac gcattgaaca gattgaggga aatcctgtta
    22141 cagtcggtga aattgatatt actctttaca gagacgatct ttctaaaaaa acgagcaacg
    22201 atgaac
//
