LOCUS       c00044_gnlPro..        16754 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KEEDCBCM_44.
ACCESSION   c00044_gnlPro..
VERSION     c00044_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 03:42:28
            Original ID  :: gnl|Prokka|KEEDCBCM_44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16754
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16754
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1781:6754]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1782..6754
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16754
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16754
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..109
                     /locus_tag="ctg44_1"
                     /transl_table=11
                     /translation="FLKLKAFRRIATRYDKLASTFAAFICIASILIWLK"
     CDS             212..481
                     /locus_tag="ctg44_2"
                     /transl_table=11
                     /translation="MTQQQYGIHTLHSNNLYQIFTYVKNKEFELRNYEHTVSGMLLYAQ
                     TDEDIIPNNTYHMSGNQISVLALDLNQDFSKISRTLDDIAKNFL"
     CDS             898..1086
                     /locus_tag="ctg44_3"
                     /transl_table=11
                     /translation="MPMKPKEMIRLLKKNGFIKISQNGSHVKMKNFKTGKQTTVPLHSK
                     DLKKRLEDAILKQAGLK"
     CDS             1132..1521
                     /locus_tag="ctg44_4"
                     /transl_table=11
                     /translation="MKKLFYPAVFHIAEEGGYWVTFPDFPECLTQGENMQEAYDMAIDA
                     LGLILTDDINDHKELPEPSNITHVDDGVVVIIPYDYLEYNRKYHNKSIKKTLTIPEWLN
                     NEALRLNLNFSQILQDALLNKIQSR"
     CDS             complement(1782..3194)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_5"
                     /sec_met_domain="HMGL-like (E-value: 1.5e-43, bitscore:
                     139.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 7.7e-59, bitscore:
                     189.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVDATKKEGGHAQIALSYTIGDAYTLDYWKK
                     TAKNIEEMGADSICIKDMAGLLVPNEATRLVTALKQATDIPIELHTHYTSGVGGMTYLK
                     AVEAGVDIIDTAISPFAMGTSQPATEVMAETFRGTEFDTGFDQKLLGEIADYFRPIREK
                     YIANGLMSPKVLGVNIKTLMYQVPGGMLSNLVSQLEQQGASDKFYEVLEEVPKVRKDFG
                     EPPLVTPSSQIVGTQAVLNVLTGERYKMITNESKALLRGEYGQTVKPMNKEVQKKAIGD
                     EKPITCRPADLLEPELSKIEAEMSQWKEQDEDVLTYALFPQVATEFFKYRAAQENKIDP
                     AKADVKNGAYPV"
     CDS             complement(3352..4476)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_6"
                     /sec_met_domain="OAD_beta (E-value: 2.3e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(4510..4878)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_7"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.7e-21, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEASAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             complement(4973..5317)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_8"
                     /sec_met_domain="OAD_gamma (E-value: 1.1e-27, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSADKLV
                     VRSIKRVKRR"
     CDS             complement(5330..6754)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_9"
                     /sec_met_domain="CT_Vparvula (E-value: 1.9e-137, bitscore:
                     449.5, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNSKMNARERIDYLFDDHSFVEVGGYVSARNTDYNLGAKKVEGD
                     GVITGYGVINDRMVYVYSQDASALGGSVGEMHAKKIASLYDLAMKTGAPVIGMLDCAGL
                     RLQEATDALHAFGTIFNKQAQASGMIPQISAVFGMCGGGSAVMSAMSDFTLMEKENGSL
                     FINSPNALAGNEESRQNTAGAQFQSEQAGNVDFVCETEEGLLDQLRILVDVLPSDYEAE
                     DVYFDNDDDLNRVIPELNDAAYDAAYILKSISDNNMYIETKAAYAKEMVTAFIRLNGET
                     VGAVANQPVDGESVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALA
                     LAKFTTTLAQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPQASVGMMDAEQAVR
                     IMYAEEINTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEM
                     LYGKKVTPVTKKHTAV"
     CDS             7477..8118
                     /locus_tag="ctg44_10"
                     /transl_table=11
                     /translation="MENRKIQFRSKACNLHLSAYPGHFATKHSHVNYFLDMTTLKVRQS
                     NAEEAARALVPLYKHNTVVDTIVCLDGTEVIGAFLAEKLTESGFFSYNQHKSIYIVTPE
                     IDSDGQMFFRKNIQPMIKDRNIIILMASVTTGITINRSWECIEYYGGKLQGISAIFSTL
                     SEYGNLPVNALFTPNDIPTYHTYDKHDCPYCKSGQKIDALVNGHGYSELL"
     CDS             complement(8252..9265)
                     /locus_tag="ctg44_11"
                     /transl_table=11
                     /translation="MQKIPECRSMNFSIYEGMLNRYKDSEDIRKSYESRGLNGLEVIRA
                     GEPDEGKILPDMVNGVHLYFHIFWMDWWKGNYERLDQEFDSREQWLEYFGGMSRESYLN
                     SLRDDLAYAEQVGAKYVVFHVSEVTLRESYIYKYRYTDKEVIDASLEVINTLLDEKEYP
                     FDFLVENLWWSGLTLKNVRLTRRLIEGMHTQKKGIMLDTGHYMNTTTQLKTPEDAIAYL
                     NKMIDKYEKAQMLHWFKGMHLQLSLGGDYVRKQRKEWREHPIDFDKIPFYELFRLAYDH
                     ACHIDLHQPFIGEGVREFVERVAPKYITLEYQQNSREEYEQFVETQSKILKWITIH"
     CDS             complement(9402..10376)
                     /locus_tag="ctg44_12"
                     /transl_table=11
                     /translation="MADWKSSQEFLKEFYASPIVNEDTISAKIKRIFLPKSRKASALKE
                     LAGDLSGEGRAGDVILDNDMFEMDTEIWKKQEKRRLSVRTRVSLFLLLVAIPLTIAVGF
                     YVMDVAAVGTVFEKIFGPRKYYFISLVIIIYSLLPFFMVFEGRKPQVRELVVLATMVAL
                     ATAGRAAFFMIPSFKPIIAIVIISAIAFGGEAGFLVGAMTMVVSNFLFGQGPWTPWQMF
                     AMGFIGFLSGILYRIGLLPTKRLSLCIYGFLVTVFIYGGIMNPAALFMSVYDFTWEGLL
                     AIYISGIPVDLVHASSTFIFLWIGAKPLLEKLQRIKIKYDLMR"
     CDS             complement(10380..12161)
                     /locus_tag="ctg44_13"
                     /transl_table=11
                     /translation="VTANGLSEKKNSILEINDLCFAYPEEKKRALNHASLHVEDGEFLV
                     LCGKSGCGKSTLLTHLKTPLTPHGKRKGEILFQGVPIGEMSNREQSQRIGYVLQNPDNQ
                     IVTDKVWHELAFGLESLGYSNADIRIRVAEMASYFGIQDWFYKNVSELSGGQKQLLNLA
                     SIMAMHPDMLILDEPTSQLDPIAASDFLETVKKINRDLGTTIILTEHRLEEVFPSADRV
                     VVMDEGQILCVGTPPEIGEELKKRNHEMFLAMPVPMQVYAKVESEQPCPITVRDGRKWL
                     DIVCKKKGISPANASSSYRKESDSQKGKSSFAKITEKFTEKKEDIILACDDLWFRYDKE
                     LPDVVKGLSFSLKRGEFFALLGGNGTGKSTTLSLLSRLRKPYRGKVLLEGKDIRRYSDK
                     ELFRNFLGVLPQNPQSLFVKKSVELELFEMVGGVKEKKDEEYQLAMDKKDAVEGIIKVT
                     HLEELLHRHPYDLSGGEQQRLALAKILLLRPKLLLMDEPTKGLDSYFKKEFAGILALLK
                     EQGVTVFMISHDIEFCASYADRCGLFFDGNIVACGTPGEFFAGNNFYTTAANRMARRYF
                     PMAVTGEDVVECLKKGV"
     CDS             complement(12203..13144)
                     /locus_tag="ctg44_14"
                     /transl_table=11
                     /translation="MKDTFSTYHPVLNMLYFCGTIGVTMFVVHPVILAISFICAVAYSV
                     VLKGWKKTVKFNLLFSLPMMIIVALINPMFNHYGVTIIGYLHNGNPFTLESCVYGLVMA
                     VMLVCTLVWFSCYTVVMTSDKFIYLFGRIIPALSLVLSMCLRFVPKFIKEASVISDGQK
                     CVGRSVENGSLIKRAKHGITIFSILVTWSLENAIETSDSMKCRGYGEKGRTAFSLYHFD
                     KRDFLCLIFMIITFGAAMWGFSKGYAFCSYNPRIVVKGVPFTAGSLLVFAAFLLFSIMP
                     AAMEILDRRMWKARRGQVESAAPAGYRLWEVE"
     CDS             complement(13221..14429)
                     /locus_tag="ctg44_15"
                     /transl_table=11
                     /translation="MDKTETLADVNNIPEDGVITKEQFKTVAGENKKVQFKGTTDDGIT
                     YIWTYDCSKIQNPADQNLKIDFSEKDLDDLKKQANNANDALKMTMYGKGLICVPDLEVQ
                     LPEAWQSNSAYLVKEQSGKLARMSDVVVTAQVKEENKKKQDTKTEEKDSSDKTAKSTTQ
                     AKKDTKPKEGTTSLKMSVTSLDGDCYIIGGITEQQNKGAASANKAENGTTNSESEGSDE
                     SGNSGENSYNEEGSSGSGDVSDGGASSSGSSGKQDVANDEEVSGSSHTCTISISCATIL
                     NNMSDLKSGKEEFVPSDGWILAASEVEFTEGESVHDVLQRVCKDAGIQMESSFTPAYNS
                     AYVEGINNLYEFDCGQLSGWMYNVNGWFPNYGCSKYTVQDGDVINWVYTCNLGKDVGDN
                     SMY"
ORIGIN
        1 ttttctcaag ttaaaagcat tccgtcgaat agccacgcgt tatgataaat tagcatccac
       61 ttttgcagca tttatatgca tcgcctcaat attaatttgg ttaaaatgaa caacttaaaa
      121 tgtttttcaa acacgctcta ggatgcagac agatattatg ttatccaaaa acaataacat
      181 acttattatt gatgccaaat attattcgca tatgacccag caacaatacg gaatacatac
      241 tctgcattcc aataatcttt atcagatttt tacctatgta aaaaataagg aatttgaatt
      301 gagaaactat gaacatactg tatcaggaat gcttctttat gcacaaaccg atgaagatat
      361 tattcctaat aacacctacc atatgagcgg aaatcagatt tctgttcttg cattagattt
      421 aaaccaggat ttttcaaaaa tctccagaac tttagatgac atcgccaaaa attttcttta
      481 aaatttttaa aggaagggac ctaatatccc ttccttactt ctattacccc tattgtaaca
      541 aaaaatctat aaacttcctc ataaagcgaa gaaccaaaat ggatacacct atagctgccg
      601 ctatacatac aattgaaaaa aacatctgaa aaatcacctg actatccata gcatatgaaa
      661 ctgcgttatt cattgtatct ccccctgact atcttttgat acttcatttt accatatctc
      721 tgtattttta tcaaaaattt ttcattttaa aaattacatt ttttatattt ttttacattt
      781 attagttgtt tttcttctta aatatgatat actattcctc accagttgta tcaccgagtt
      841 cttgacacac gtatactata cgtattataa tataattata gaaaggggtg gcatactatg
      901 ccaatgaaac caaaagaaat gataagatta ttaaaaaaaa atggtttcat aaaaataagt
      961 caaaatggtt cccatgtgaa aatgaagaat tttaaaactg gcaaacaaac aacagttcct
     1021 cttcatagca aagatttaaa aaaaagacta gaagatgcca tcctaaaaca agcgggctta
     1081 aaatagcctt atttcatcta taataactca catacattgg aggtatccat tatgaaaaaa
     1141 ttattttatc ctgctgtatt tcatattgca gaagaaggcg gttattgggt gacttttcct
     1201 gactttcccg aatgtctaac tcagggagaa aatatgcaag aagcctatga tatggctata
     1261 gatgctttag gacttatctt aactgatgac attaacgacc ataaagaact tccagaaccg
     1321 tctaacatca cacatgttga tgatggagtt gtcgtaatca tcccatatga ttatttggaa
     1381 tataatcgaa agtatcataa taaatctatc aaaaaaactt taacaatccc tgaatggttg
     1441 aataacgaag cattgcgatt gaatttaaac ttttcacaga ttttgcagga tgctctttta
     1501 aacaaaattc aatctcgtta atggctataa ttctttcatt tggtaatact gcaatcatag
     1561 attataatat acttaacaag gcagctaata cgatagcttc acctatccat ttccggcaag
     1621 tttaggttaa aaaacagaac ccccacaact ttatagatag caaatgtgat gtcggagcaa
     1681 gtaaaaatgc ggctgagcat tttctacgca gcgaaatctt cacatgtgct atctataaag
     1741 ttgcgggggt tcgtctgttt ttaatctaaa tcaatccaat cctacaccgg atatgctcca
     1801 ttctttacat cggcttttgc aggatcaatc ttattctcct gtgccgctct gtatttaaag
     1861 aattcggttg ctacctgtgg gaacaatgcg tatgtaagca catcttcgtc ctgttctttc
     1921 cactggctca tctctgcctc gatcttagat aattccggtt caagaaggtc ggctggacga
     1981 caggtaattg gcttttcatc gccgattgcc tttttctgta cttctttatt cattggtttt
     2041 acggtttgac cgtattctcc acgaagaagg gcttttgact cgtttgtaat cattttataa
     2101 cgctctccgg taagtacatt taatacagcc tgtgttccga caatctgact ggacggtgta
     2161 actaatggtg gttcaccgaa gtctttacgt acttttggaa cttcctctaa tacttcatag
     2221 aacttatcgg atgctccctg ctgctctaac tgagatacaa ggttagaaag cattccacct
     2281 ggaacctgat acattaaagt cttgatgttt acaccaagta cctttggact cattaagcca
     2341 tttgcaatgt atttctcacg gatcggacgg aagtaatctg cgatttcacc taaaagcttc
     2401 tggtcaaatc ctgtgtcaaa ttctgtacca cggaatgtct ccgccataac ttctgttgcc
     2461 ggctggcttg ttcccattgc aaatggagat atggctgtat caatgatatc gactcctgct
     2521 tctactgctt ttaagtaagt cattccaccg acaccacttg tatagtgtgt atgaagttcg
     2581 ataggaatgt ctgttgcctg ctttaatgca gttacaaggc gagttgcttc attcggcact
     2641 aaaagtcctg ccatatcttt gatacagata gaatctgctc ccatctcttc aatattctta
     2701 gcagtctttt tccagtagtc taatgtatat gcatcaccga ttgtatagga gagggcgatc
     2761 tgcgcgtgtc ctccctcttt ctttgttgca tctacagcag tctgtaagtt tctaaggtca
     2821 tttaaacagt caaaaatacg aataacatca attccgtttg caatagattt ctgtacgaaa
     2881 tattctacaa catcgtctgg atatggctta tatcctaaga tgttctgtcc acggaataac
     2941 atctgtaact ttgtattctt aaagccatct cttaatttac gaagtctctc ccatgggtct
     3001 tcctttaaga aacgcaggca ggcatcaaat gttgcacctc cccagcattc tactgcatga
     3061 taaccaacct gatccatctt atctacgatt ggcagcatct cctctgttgt cattcttgta
     3121 gcaatcagag actgatgtgc gtcacggaga acggtttcta ctattttaac cggttttttc
     3181 ttaatttcgg ccataatatc tccttttatt tcaaatcacg taactatttg cgcttacaac
     3241 tgttattatc taaaattcaa cttgtaaact atttataaat atcccctgta acatttttta
     3301 cagattgtag ccctataaat aatgaatttt aaataatcaa ataattctaa attatactcc
     3361 aaaaattgcc ataaatgttc cggcggctac cgctgtaccg ataactccgg caacatttgg
     3421 tcccatcgca tgcatcagta agaagtttga tggatctgct tccgcaccaa ctttctggga
     3481 tacacgggct gccataggaa cggcagatac cccggcagaa ccaattaatg gatttacctt
     3541 accacctgta accttacaca taagtttacc aaacaggaca cctgctgcag taccaacagc
     3601 aaaagctaca agacctaata ctacaatctt gattgtgctg acatttaaga atgcctctgc
     3661 acttgttgtc gcaccaacgg atgtaccaag aataataact acgatgtaca taagagcgtt
     3721 agacgctgtc tctgaaagct gttttactac gccggactct ctaaaaaggt taccgagcat
     3781 cagcatacca actaatggtg ctgttgtagg aagaatcaga catacaacaa ctgttacaac
     3841 gatagggaac ataattttct ctgtttttgt aacggttctt aactgttcca tcttaatctg
     3901 acgttccttt tctgtagtaa ggagcttcat gatcggtggc tgaataattg gtacaagtga
     3961 catataagaa tatgccgcta ccgcaattgg tcccattaag tctgtctgcc caagctttcc
     4021 ggcaaggaaa atagaagtag gaccatcggc tccaccaata atggaaattg ctgctgctgc
     4081 ctttccgtta aatcccataa gcattgcaag gaaatacgcg ctgtaaatac caaactgcgc
     4141 cgcagctccc agcaagaaac ttgctggatt ggcaatcagc ggaccaaagt ctgttagtgc
     4201 tccaacacct aagaaaatca gtgaagggag aatactccat tcatctaata agtaaaaata
     4261 atgtaataat ccgccttctt ccataatgga cggatataag ttaaccagca gcataccaaa
     4321 agaaatcggc actaacaaaa gtggctcata tcctttggcg atggccagat ataagaagac
     4381 taaagcaacc agtatcataa tgaagttacc tggctttaag aatgcaaatc cggtctgtgc
     4441 tgcgagattc gtcattgtct ctacaacata actcataaat cttcctccgt tttattttgc
     4501 aaatatgctc tagttcattg tagccagtac atctccgcct tctaccatat ctccaactgc
     4561 tacttccaca cttgcgataa caccatcctg tgctgcacag atttcattct ccatcttcat
     4621 agcctctaat acaagaacag cgtcgccctt ctttacagaa gcacctgcct gtgcctttac
     4681 tgctacgatc ttacctggca ttggtgctgt aatctttacg gcaccggcac ttccggaagt
     4741 ctttggggca gctttcttag ctggagccgg aacggctgct ggtgtactta ccggcgctgc
     4801 acttgcttct cctgcaccta attcttctac tgctacatca taagcaacac cattaactgt
     4861 aattctataa tttttcattt taaatcctcc tgaatgattt tatgtacttc taaaatcttt
     4921 ctatagctaa cttttcaaaa ctttataaaa agattccaag aatacatttt tgctatcttc
     4981 tcttcactct cttgattgaa cgaacgacca acttatctgc actgactgct gctcctccat
     5041 tcgctgccat gattgccgct gtgattactg cgacaagttc accatcatcc acaagttcct
     5101 cttcttccac aacttcttca agaatcggac gctttggagc cggtctttct tcctgcgcag
     5161 cctttttctc tttcttagaa gaacgattct ttaacgctct ttcaatagat gggatatata
     5221 caaaaagaga aatcagtaaa gaaatgaaaa tcagtactgc aaatacagtt cccataccca
     5281 tcaaagtatt taataaggct tgttcaaata cgttcatact ctcacctcac tatactgccg
     5341 tatgcttctt tgtcactgga gttactttct ttccgtaaag catttcataa gcagcgataa
     5401 gacgctttct tgttgcgtcc ggctcgatga tgtcatctat atatcctctc tttgcagctg
     5461 ctaatgcact gctctgtcct tctgcatatt ccgcagtttt ctctgcgata agtgctgtct
     5521 tattcttatc tgtattgatt tcctctgcat acatgatacg aactgcctgt tctgcatcca
     5581 tcattcctac agatgcctgt ggccatgcca gaacaaagtc agctccgata gctttagaat
     5641 tcattacttc cgctgcagtt ccataagcct cgcctgcaat gagattaata cgaggtacac
     5701 taacctgtgc aagtgttgtt gtaaacttcg ctaatgcgag cgcctgcttt ctctcttcat
     5761 gtgcgttggc acgaagtcct gtcacgttcg ttacagtaag aagaggaatc gaaaatgcat
     5821 cacagaactt aataaatctt tctgcttttt caagaccatt tcttgttaaa acggactcac
     5881 catctactgg ctggttggca accgcaccta ctgtctctcc attcagacgg ataaatgcag
     5941 ttaccatctc tttggcatag gctgcctttg tctctatgta catattgttg tcagaaatag
     6001 attttaaaat gtaagcggca tcatatgcgg catcatttaa ctcaggaata accctattta
     6061 aatcatcatc gttatcaaag taaacatctt ctgcttcata atcagaagga agtacatcaa
     6121 cgagaatacg aagctggtca agaagtcctt cttctgtctc acatacaaaa tctacgttac
     6181 cagcctgctc agactggaac tgtgctcctg ccgtattctg acgggattct tcattccccg
     6241 ctaatgcatt cggactgttg ataaagagac tgccgttctc cttctccatc aatgtaaaat
     6301 cagacatagc ggacattacg gcacttcctc ctccacacat tccaaatact gcagaaatct
     6361 gtggaatcat tccagatgcc tgtgcctgct tattaaaaat cgttccaaat gcgtgaaggg
     6421 catctgtcgc ttcctgtaat ctaagtcctg cacaatccag cattccaatg actggcgcgc
     6481 ctgttttcat cgccagatca taaagggaag caattttctt cgcatgcatc tcacctacgg
     6541 aacctccaag tgcggaagca tcctgactgt aaacataaac catgcggtca ttaataactc
     6601 cgtatccagt gataacacca tcaccttcta ctttctttgc accgagatta taatcggtat
     6661 tacgagcgga aacatatcca ccaacttcca caaaactgtg gtcatcaaac agataatcaa
     6721 tgcgctctct ggcattcatt tttgaattac ccatattctt tcctccataa aaatgctata
     6781 ttgtatacct tgttgctctt tcattctatg taataataac aaattattat catgttagca
     6841 accattttct gttagttatt taacatttat tttattttgc ccattccact aaacaaaatg
     6901 agcattctgc ctatttgcaa attttttaac aattctttca attttctttc tgaatctcct
     6961 gtttttttca ggaacgcttg tgtatttttc ctgtttttct ctattttatc tttaaaattc
     7021 tatttttgtt ttatatgtcc atttttattt cgttataatt ttaacgtatt ttgacattca
     7081 attactagtt ggtttttcta ttttttcgtc attttataca aaatattctc attctatcaa
     7141 atatcttccg tttttcttca taatttcact cttatttcca tcattcttct tttctcgctt
     7201 atattctcct cctgtctttt ttaaatcaaa gatatagtat ccaaaatcaa ttttgaacta
     7261 tttttgtcaa acttttttca caaactaata gcgctccctt tcattttata caactgtata
     7321 tgcataccat gaagtatttt caaaaaatca gaaagaaatt ataaactgtc aagaaaagcc
     7381 tgtaattttg cacaaatact cctttatttt ttcacacaaa aaaggtataa taaacaaaat
     7441 aaacaattct ttcacaataa aggaggagga catcttatgg aaaaccgcaa aattcaattt
     7501 cgttcaaaag cctgtaatct acatctttct gcctatccgg gacatttcgc aacaaagcat
     7561 tctcatgtca actacttttt agatatgaca acattaaaag tacgtcagtc taatgcagaa
     7621 gaagctgcaa gagcgttagt tccactttat aaacataata ccgtcgtcga taccatcgta
     7681 tgtcttgacg gaacagaagt aatcggtgca tttttagcag aaaagcttac agagagcgga
     7741 ttcttctctt acaaccagca taaatctatc tatattgtta ctccagaaat agattcagat
     7801 ggtcagatgt tcttccgcaa aaacatccag ccaatgatta aagatagaaa tatcattatt
     7861 ttaatggcat ctgtcacaac tggaatcaca atcaaccgaa gctgggaatg tatcgagtac
     7921 tatggtggca aactgcaggg aatttcagca atatttagta cgctttctga atatggtaat
     7981 cttcctgtta atgcgctgtt tactccaaat gatattccta cttaccatac atatgataag
     8041 catgactgcc catattgtaa gagtggtcag aaaatcgatg ctttggtaaa cggacatgga
     8101 tattccgaat tactataact actaatttgt agatttcgta tagacgaaaa aaagaaacca
     8161 taccatatcc cagatgcgga tgagcatttt aaacacaacg actacagagc agatgggata
     8221 tggtatggtt tcttttttcg tctgttttct cttaatgaat cgtaatccat ttcaaaattt
     8281 tactttgggt ttctacgaat tgttcatatt cttcccggct gttttgctga tattccagcg
     8341 tgatatactt tggtgctacg cgctctacaa attcccggac accttctccg ataaaaggct
     8401 gatgcagatc aatatgacag gcatggtcat atgcaaggcg aaatagttca taaaatggaa
     8461 tcttatcaaa gtctatcgga tgttctctcc attcttttcg ctgctttctt acataatccc
     8521 ctcccagtga caactgcagg tgcattcctt tgaaccagtg gagcatctgt gctttttcgt
     8581 atttgtctat cattttattc agatatgcta tggcatcttc cggagtcttt agctgtgttg
     8641 ttgtattcat ataatgcccg gtatcgagca tgattccctt tttttgtgta tgcattcctt
     8701 ctataagccg gcgggtaagg cggacatttt tcaaggtaag cccgctccac cagagattct
     8761 ctacaagaaa gtcgaatgga tattcttttt catcaagtag ggtattgatg acctctaagc
     8821 ttgcatcaat cacttcttta tctgtatagc ggtatttata aatatagctc tcccggagtg
     8881 tcacttctga aacatggaaa actacatact ttgctccaac ttgttctgca taggcaagat
     8941 cgtcccgcaa actgttcaga taagattccc tgctcattcc tccaaagtat tccagccact
     9001 gctctcttga atcaaattcc tgatctaggc gttcataatt ccccttccac cagtccatcc
     9061 agaaaatatg aaaatacaga tgtaccccat tcaccatatc cggcagaatc tttccttcat
     9121 ctggctcgcc tgcccgaatc acttccagtc catttaatcc tcgtgactca taagactttc
     9181 taatatcttc actatcttta taacgattta gcatcccttc ataaattgaa aaattcatgg
     9241 aacgacattc tggtattttc tgcatagttt cccccttcaa tctcgtatac tctcagaatc
     9301 tttctaagaa tacattttat ctatacttat catccatact tatttcaaaa atgccccatc
     9361 attctggcaa tctttctaaa gttcaaaaac gccccggcta ttcatctcat cagatcatat
     9421 tttattttta tccgctgcag cttttccaac aatggctttg ctccaatcca cagaaaaata
     9481 aatgtagaac tggcatgaac aagatctacc ggaatacctg aaatatagat tgcaagcagt
     9541 ccttcccatg taaaatcata cacactcata aagagagccg ctggattcat gattcctcca
     9601 taaatgaaca ccgtcacaag gaatccatat atacaaaggc tgagccgttt ggtcggaagc
     9661 agtcctattc ggtaaaggat tcctgacaaa aatccgataa aacccatcgc aaacatctgc
     9721 catggggtcc atggtccctg cccaaataag aaattgctga ctaccatcgt catggcacca
     9781 actaagaatc ctgcctcgcc gccaaatgcg attgcactga tgatcacgat tgctataatc
     9841 ggcttaaagc tcggtatcat aaaaaatgct gcccggccgg cggttgccaa tgctaccatt
     9901 gttgcaagaa caactagctc tctcacctga ggttttcgtc cctcaaatac cataaaaaac
     9961 ggtaataacg agtatataat gattaccagg ctaataaaat aatactttct tggaccaaaa
    10021 atcttttcaa atactgtgcc aacggcggca acatccataa cataaaatcc gacagcaatt
    10081 gtgaggggaa tcgctacaag caagagaaag agacttactc tggtacgaac agaaagcctg
    10141 cgtttttcct gctttttcca gatttcggta tccatctcaa acatatcatt atctaaaatg
    10201 acatctcccg ccctgccttc tcctgacaaa tctcctgcta attcttttaa agcagaagct
    10261 ttcctgcttt ttggtaaaaa gatacgcttt atctttgcag aaatcgtatc ttcattcacg
    10321 attggagaag cgtaaaattc tttcaagaac tcctgacttg atttccagtc tgccattgtt
    10381 cacactcctt ttttaagaca ttccacaacg tcctccccgg taaccgccat gggaaaatac
    10441 cttctagcca ttcggtttgc cgctgttgta taaaaattat ttccggcaaa gaattctccc
    10501 ggagttccac atgccacaat atttccatca aaaaataaac cacatcggtc tgcatacgaa
    10561 gcgcaaaact caatatcatg agaaatcata aaaacagtta cgccctgctc tttgagtaat
    10621 gccagtattc cggcaaattc ttttttaaaa tagctgtcaa gtcctttggt cggttcatcc
    10681 atcaacaaaa gctttggccg caataacaaa atcttagcca gggcaagcct ctgctgctct
    10741 cccccgctta agtcatacgg atgacgatgc agtaattctt ccaaatgtgt tactttaatg
    10801 attccttcca ccgcatcctt tttatccatg gcaagctgat attcttcatc ctttttctct
    10861 tttacaccgc ctaccatttc aaacagttct aattccacac ttttctttac aaaaagggac
    10921 tgcgggtttt gcggcagtac tccaagaaaa ttgcggaaca gttctttatc gctgtaacga
    10981 cggatatcct taccttctaa aagtactttt ccacgatatg gctttctcaa acggctcaaa
    11041 agtgaaagtg ttgttgactt cccggttcca tttcctccaa gcaatgcaaa gaattctcct
    11101 ctttttaagg aaaagcttag tccctttacg acatccggca gttctttatc atagcggaac
    11161 cacagatcat cacacgctaa gatgatatct tcttttttct ctgtaaactt ttctgtaatc
    11221 ttagcaaaag aagattttcc tttttgggaa tcactctctt ttctatatga agaagatgca
    11281 tttgctggtg aaatgccttt tttcttgcaa actatgtcca gccactttcg cccgtcacga
    11341 acagtaatcg ggcagggctg ctctgactct actttggcat aaacctgcat cggcaccggc
    11401 atagctaaaa acatctcatg attgcgcttc tttaattctt ctccgatttc cggcggtgtg
    11461 ccaacacata aaatctgccc ttcatccatg accactaccc tgtcagcaga aggaaatact
    11521 tcctctaaac gatgttccgt aagaataatt gtcgttccaa gatcacgatt aatcttcttt
    11581 actgtttcca aaaaatcaga agctgcaatc ggatcaagct gagaggtcgg ctcatcaaga
    11641 atcagcatat ccggatgcat ggccatgata gatgccagat tcaaaagctg tttctgtcct
    11701 ccggaaagtt ccgatacatt tttataaaac cagtcctgaa tcccaaaata acttgccatt
    11761 tccgctaccc ggatacggat atctgcgtta ctgtatccaa ggctttccaa accaaatgcc
    11821 agctcatgcc acactttatc tgtcacgatc tgattatccg gattctgtaa tacatatcca
    11881 atcctctgac tctgctcccg gttactcatc tccccgattg gtactccctg aaaaaggatc
    11941 tctccttttc gctttccatg cggcgtcagg ggagtcttta aatgtgtcag aagtgtactc
    12001 tttccacatc cactctttcc gcaaagaaca aggaattccc cgtcctccac atgcaaagaa
    12061 gcatgattta gcgccctctt tttttcttct ggataagcaa aacacaaatc attgatttct
    12121 aatatactat ttttcttttc tgacaaacca ttcgctgtca ccctgcacct ccaaacttgc
    12181 tttttatctc ctgtatatac ggctattcaa cttcccacaa acggtaccca gccggtgctg
    12241 cactttctac ctgtcctctt ctcgccttcc acatccttcg gtctaaaatc tccatcgctg
    12301 ctggcatgat actaaacaat aaaaaagcgg caaagacaag caggctgcct gctgtaaagg
    12361 gtactccctt tacaacaatc cgaggattat aagaacaaaa tgcatacccc tttgaaaagc
    12421 cccacatcgc tgctccgaat gtaatgatca taaaaataag gcacaaaaaa tcccttttat
    12481 cgaaatgata taaggaaaag gcggttctgc ccttctctcc atatccccgg cacttcattg
    12541 aatccgatgt ttcaatcgca ttctccaaag accaggtaac cagaatcgaa aaaattgtaa
    12601 ttccatgctt tgctctctta ataaggctcc cattctctac acttcgcccg acacactttt
    12661 gcccatcaga aataacagat gcttctttga taaacttcgg tacaaagcga aggcacatgg
    12721 aaagtactaa agaaagtgcc gggatgatcc ttccaaaaag ataaataaac ttatctgatg
    12781 tcataacaac tgtgtagcag gaaaaccata caagagtaca taccagcatc actgccatca
    12841 caagaccgta cacacaactt tctaatgtaa acggatttcc attatgaaga tatcctataa
    12901 tcgttactcc ataatgatta aacatcggat tgatcagggc aacaatgatc atcatcggta
    12961 atgagaagag cagattaaac tttactgtct ttttccatcc ttttaaaaca acggaatacg
    13021 caacagcgca tataaatgaa attgccagaa tcacaggatg aacaacaaac atcgtcaccc
    13081 cgattgtccc gcaaaaatac agcatattta aaacaggatg atatgtcgaa aatgtatctt
    13141 tcatctaaat caaatctcca ttacatcaaa tttctattat attaaatctt tattatatca
    13201 aatctctatt tcatacatcc ttaatacatc gaattatctc caacatcctt accaagatta
    13261 catgtataaa cccagttgat cacatcgccg tcctgtaccg tatacttact gcatccgtag
    13321 ttaggaaacc agccatttac gttatacatc catccagaaa gctgtccgca gtcgaattca
    13381 tacagattat taattccttc cacataagct gaattataag ccggtgtaaa agaagactcc
    13441 atctggattc ctgcatcctt acatacacgc tgtaatacgt catgtacaga ctctccttcc
    13501 gtaaattcta cctcggaagc tgccagaatc catccatcag aaggaacaaa ttcttccttg
    13561 ccacttttta aatcactcat gttattaaga atcgtcgcgc agctgattga aatcgtacac
    13621 gtatgggaag aacctgaaac ttcttcatca tttgcaacat cctgcttgcc ggaagaacca
    13681 gaagaagaag ctcctccatc agaaacatct ccacttcctg aacttccttc ttcgttataa
    13741 gaattctctc ctgaattccc cgattcatca cttccttccg attcactatt cgttgttccg
    13801 ttttccgcct tattcgctga tgccgcacct ttattctgct gctccgtaat tcctccaata
    13861 atataacaat ctccatccag tgaagtaaca ctcattttta aagatgtcgt tccttctttt
    13921 ggcttcgtat ctttctttgc ctgtgttgta ctttttgcgg ttttgtccga agaatctttc
    13981 tcttctgtct ttgtatcctg cttcttttta ttctcttcct tcacctgtgc tgttaccaca
    14041 acatcgctca tccttgcaag ctttccagac tgctctttta caagatatgc agaattggac
    14101 tgccacgctt ccggaagctg tacctcaaga tccggtacac agatcagccc tttcccgtac
    14161 attgtcatct tcaatgcatc attggcattg ttcgcctgct tctttaaatc atcaagatct
    14221 ttctctgaaa aatcaatctt taaattctga tctgccggat tctgaatctt tgaacagtca
    14281 tacgtccaga tatatgtaat tccatcatct gttgtcccct taaactgtac ctttttattt
    14341 tctccggcaa ccgttttaaa ctgctccttt gtaataaccc catcttccgg aatgttattc
    14401 acatctgcaa gtgtctctgt cttatccatc tttttatcag aagaactgtc tccactcccg
    14461 gactttccac agcccgttga aacaatcagc agcatactca taagcaatgc caaaacgaca
    14521 tataccagac ctttttcctt tttcataata gtaccctttt tcctttctat tattataaat
    14581 ttttatacga aagcttcttt atatccgctg tgaaataact cagcattctt atattctaca
    14641 cgatgctttt tcaccaacgc tactctgtat ctccacctct gccaaacttc tttagcactc
    14701 ctgcgatagc atgacgcttt ttatacaata caaagacaag tacccctact acaactcccc
    14761 cgattatata aaatattacc atccatttga taccttcttt tttcgagcct gtatccgatg
    14821 tctccgtatc ctcttgtgcc acctcatctt cgctttctgc cgaattcgta tccggcacat
    14881 aattatctcc gctaaaactc cagccacccg tcgtttcttc tgccgcagtc ttctttttct
    14941 ttgctgttgt tcccgttgct gccttcgcag aatttccgct atttccggaa ggaagcttct
    15001 ttgtagtccc tgatgcagcc ggaacagacg aacttacggt gctgtttccg gaagtgaccg
    15061 gtgctgtaac ccgcttcgtc tgacttcttg ttgttgctgt tgtaggattt ttctttgctg
    15121 ttgttgccgg tgcagttacc acaactttac aaattgcctt ttttccactt ccatccttcg
    15181 cttttaccgt aatcattgca cttccagctt tcttccctgt cacctttccc tttgcattta
    15241 ctgttgcaat ctttttattg gaagaagacc atttcactga cttcttcgtg gcatttgacg
    15301 gagaaaccgt cgcttttaac gtcttactct ttccttttgt aagataaatc gtactataat
    15361 ttaatcccac ttttattacc tttactttag aagctgccgg ttttgtttct gtcttttttg
    15421 ctgtcgttga agaagaattt cctccactat tactccccgt atcaatcgtc ggactgacta
    15481 ccggcttcgt tcctgccgaa atagccacat cactcatatc ataaagaaat gtctctccat
    15541 ccaaaaatct acggtaagca actgttgcat acaatccctg ttccgttgcc attccatcga
    15601 taatgccacc ggcaccgcca ccattattcc cggcatcagc agctacatgc ataaatcccc
    15661 cttctggcat ataatactgg aataatcctg tcatcggcca tttcccattc ttaataaaac
    15721 gggcatcttc tccacaatct attcccacac cgcaaagagc tgtgataatc tgtgccacac
    15781 tttccgaagt ttctgtattc atcgtgccaa aaccaccact ggaaagctga ttcttttcta
    15841 tccatgcaag tcccttgtca attgccgctg taacatcctc atatccatct ttattataat
    15901 aagaagccag cgcctgcatc gccattcctg tcatatcgga atctccagtt gttcccatca
    15961 atgtccagcc accatcctga cactgcatcc ctacaacctt cttaacaagt aactcctctg
    16021 agttttgctg cactgcagaa gggtcttctg gaatctcata tgccggatta ctctttaatg
    16081 caatcaacgc ccaaatcgtg ccattattcc cctgtctgct tacattctca taatctgaca
    16141 gatacgctaa cagattatgt cccatcacat ttcttgcatc gacaccaatc gctgttaatg
    16201 caagaataag ctttgaataa tccgaatact ttgctcttgt aatctgccag tccttactct
    16261 cacagtatgc gatcacatta ctataaaaaa gatttatata agattccggc acatacagcc
    16321 cactcctttt taaaccaata acattccata tgctactgta atccggcttc gtatctttac
    16381 ttaagatata gcttcttacc ttagataaaa ccgtatcaat atccggactt aagacttccg
    16441 cctctgcttc cgtctgcact gccactcctg attcatcaga ctgtccctgt gccgcatctt
    16501 cctctgcacc ccaagcataa aaaccataac ttcttccaag ctgcaaattc ttacggacaa
    16561 tctttctctc tttttttgtt aatgtctgct cttgtgtact ttcctgtaca tctgcctctg
    16621 tacttgctga tgcatctgca tcttccctgg tctgctgctc ctcctcttcc gaagactccg
    16681 tctcctccct ttctgatgtc tcactttctg acgtctcact ttctgacata gaaaaatcgc
    16741 ctgtactctc tgca
//
