LOCUS       gnlProkkaJBNBAEPM_81    8946 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JBNBAEPM_81.
ACCESSION   gnlProkkaJBNBAEPM_81
VERSION     gnlProkkaJBNBAEPM_81
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 10:59:02
            Original ID  :: gnl|Prokka|JBNBAEPM_81
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8946
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..147
                     /locus_tag="ctg48_1"
                     /transl_table=11
                     /translation="MHSWGMPPVMFSVVTKYHKGRHSLFLYNSEIFYAFTQDILRSPLS
                     CPS"
     protocluster    1..8946
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1455:4767]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1456..4767
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..8946
                     /SMILES="NC(CS)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8946
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /tool="antismash"
     CDS             complement(104..748)
                     /NRPS_PKS="Domain: AMP-binding (26-193). E-value: 4.5e-17.
                     Score: 53.5. Matches aSDomain:
                     nrpspksdomains_ctg48_2_AMP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_2"
                     /sec_met_domain="AMP-binding (E-value: 8.4e-16, bitscore:
                     46.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPSSIVQTILSVSEDAQHGMYFINDEHENFVSYKDFIGRAISLL
                     RLLNRNDVNSGSMLVIQTINPQATLLLIWACFLGGITPVPCAISYSHDHLEFLKVVSKT
                     LSRPQMIFNNRFYMYLAKMARNDDKDISILDKVEIDEDAILNLQPTEIDSVEVEVADIV
                     QRLILFSSGTTGTPKGVVYSDKNLIANISIVSQTIGFSSLDSLMESVKYLV"
     aSDomain        complement(170..670)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg48_2_AMP-binding.1"
                     /evalue="4.50E-17"
                     /label="ctg48_2_AMP-binding.1"
                     /locus_tag="ctg48_2"
                     /protein_end="193"
                     /protein_start="26"
                     /score="53.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="EHENFVSYKDFIGRAISLLRLLNRNDVNSGSMLVIQTINPQATLL
                     LIWACFLGGITPVPCAISYSHDHLEFLKVVSKTLSRPQMIFNNRFYMYLAKMARNDDKD
                     ISILDKVEIDEDAILNLQPTEIDSVEVEVADIVQRLILFSSGTTGTPKGVVYSDKNLIA
                     NISI"
     CDS_motif       complement(203..250)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg48_2_0001"
                     /evalue="2.20E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg48_2"
                     /protein_end="182"
                     /protein_start="166"
                     /score="20.2"
                     /tool="antismash"
                     /translation="ILFSSGTTGTPKGVVY"
     CDS             complement(735..1466)
                     /NRPS_PKS="Domain: Thioesterase (5-232). E-value: 2.5e-24.
                     Score: 78.8. Matches aSDomain:
                     nrpspksdomains_ctg48_3_Thioesterase.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 180; E-value: 6.8e-55)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_3"
                     /transl_table=11
                     /translation="MKSDINLYCIPHAGGLASFYNIWIPYFKNTSINIYPLEMKGHGSR
                     FNENDYLSIEEAASDTFKQIMTIQKSTGNHNYAILGHSMGSYIELEFLKIIEQLQMKEP
                     IACFMSGKGAPSAVDEIHISQLSDQQFIDQIGTLGEISDELLKYPDLLSIFTSTIKDDY
                     RAVEHYDHSKKISLSEKHVFVLNGIDDVYATALNKEAWQGYFDAPITIKDFPGGHFFIK
                     DSVATVTGYILNNLEELHETV"
     aSDomain        complement(771..1451)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg48_3_Thioesterase.1"
                     /evalue="2.50E-24"
                     /label="ctg48_3_Thioesterase.1"
                     /locus_tag="ctg48_3"
                     /protein_end="232"
                     /protein_start="5"
                     /score="78.8"
                     /tool="antismash"
                     /translation="NLYCIPHAGGLASFYNIWIPYFKNTSINIYPLEMKGHGSRFNEND
                     YLSIEEAASDTFKQIMTIQKSTGNHNYAILGHSMGSYIELEFLKIIEQLQMKEPIACFM
                     SGKGAPSAVDEIHISQLSDQQFIDQIGTLGEISDELLKYPDLLSIFTSTIKDDYRAVEH
                     YDHSKKISLSEKHVFVLNGIDDVYATALNKEAWQGYFDAPITIKDFPGGHFFIKDSVAT
                     VTGYI"
     CDS             complement(1456..4767)
                     /NRPS_PKS="Domain: PP-binding (11-67). E-value: 2.1e-11.
                     Score: 36.1. Matches aSDomain:
                     nrpspksdomains_ctg48_4_PP-binding.1"
                     /NRPS_PKS="Domain: Heterocyclization (87-374). E-value:
                     8.9e-66. Score: 214.1. Matches aSDomain:
                     nrpspksdomains_ctg48_4_Heterocyclization.1"
                     /NRPS_PKS="Domain: AMP-binding (533-923). E-value: 8.2e-88.
                     Score: 286.5. Matches aSDomain:
                     nrpspksdomains_ctg48_4_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1027-1092). E-value: 1e-13. Score:
                     43.1. Matches aSDomain: nrpspksdomains_ctg48_4_PCP.1"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     77.3; E-value: 2.3e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_4"
                     /sec_met_domain="PP-binding (E-value: 3e-12, bitscore:
                     36.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.2e-39, bitscore:
                     125.2, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-97, bitscore:
                     314.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKKETNLISIIQSYSEEKNIDNNTDLFELNISSIEISQILSQI
                     NREQSIKLTFADFMNCNTVNDLQKLILDTAPQMEQRAEKQYKKNNFKPTNVQMAYLTGR
                     NSGFTLGGVSTHIYFEYDSDWDLSRFEEIINCEIRRQPMLRATFLAGKVHINKVEDCKY
                     TLNVLGSKPDDFNDVLKAQKDIQKYRNFNPSKWPLFNFTAIKNSCGKSKILFDIDALIS
                     DGFSIRILFEDLVALYRGKEVNSISNKQLLNLLDTNSENVSDKSYWQNKILTLPQAPEL
                     PYSNKFSSVKKPTFSSVRKTLPLELWNKIDKKCEAERVRPTFFLMACYAATLAKWSNQK
                     DVLINCTLFDRNNDLPNANTIIGDFTSVLLATYQRSKMFTWNSIKRFQTDFIHDYQHKD
                     FDGIEVSKLLIKRDAKPLTDVVAPVVFTSMLFNKSDKNLSLGNVQNYATQTPQVTLDHQ
                     AMLTDDGVFLNWDYVDELFDYATISAMFNDYYGLVEGFAENKNSSLASKNALAAYQIFN
                     DTKDISVLGNSMLDRFNKSVKLYSESIAVEGQESSITYGELDFKSNQIANYLLQKIQVS
                     KGDFVAIVGMRSIDTIIGILGILKAGAAYIPLSTEFPQSRIDEIKRDSLYKDMLTDEKI
                     NTILSGKINESVQPLPNITADDVAYAIYTSGSTGKPKGVVIKHGAAVNTINDIICKYNI
                     KNDDVFIGLANLAFDLSVFDVFGAFSVGAKLVLCENPRNVEEVWDLVTSSNVTIWNSVP
                     MLMEMFVTFAETKLNSEDLDFSLLPKLRLVLLSGDWIPIDLPNKITQNFMDCEVVSLGG
                     ATEASIWSIYYNVKLIDSKWKSIPYGKPLSNQTYYVLDDFYQPCPIGVTGDLYIGGKGL
                     ASGYLNNPQKTESVFINHKEFGRIYKTGDLGYLNRSGFIVFKGRNDSQVKINGFRIELE
                     EIQNVILKMPDIISVIVVVKHQEILVYYVGSVTEASILKYAGNFLPGYMMPKYCMQLKE
                     VPLTKNGKVNRRALPDFKESSINQNVSSDAPKNSVEEFLENTISDLLKVKNVNVTDNFF
                     ELGGNSLLIVELFNEVQKKYPNTIKLIDIFKNSNIFDLSKVILNQLEKKEAQNEK"
     aSDomain        complement(1492..1686)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg48_4_PCP.1"
                     /evalue="1.00E-13"
                     /label="ctg48_4_PCP.1"
                     /locus_tag="ctg48_4"
                     /protein_end="1092"
                     /protein_start="1027"
                     /score="43.1"
                     /tool="antismash"
                     /translation="LENTISDLLKVKNVNVTDNFFELGGNSLLIVELFNEVQKKYPNTI
                     KLIDIFKNSNIFDLSKVILN"
     aSModule        complement(1492..4506)
                     /complete
                     /domains="nrpspksdomains_ctg48_4_Heterocyclization.1"
                     /domains="nrpspksdomains_ctg48_4_AMP-binding.1"
                     /domains="nrpspksdomains_ctg48_4_PCP.1"
                     /locus_tags="ctg48_4"
                     /monomer_pairings="Cys -> Cys"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(1969..2034)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg48_4_0008"
                     /evalue="1.60E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg48_4"
                     /protein_end="933"
                     /protein_start="911"
                     /score="30.0"
                     /tool="antismash"
                     /translation="FKGRNDSQVKINGFRIELEEIQ"
     aSDomain        complement(1999..3168)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg48_4_AMP-binding.1"
                     /evalue="8.20E-88"
                     /label="ctg48_4_AMP-binding.1"
                     /locus_tag="ctg48_4"
                     /protein_end="923"
                     /protein_start="533"
                     /score="286.5"
                     /specificity="substrate consensus: Cys"
                     /tool="antismash"
                     /translation="NKSVKLYSESIAVEGQESSITYGELDFKSNQIANYLLQKIQVSKG
                     DFVAIVGMRSIDTIIGILGILKAGAAYIPLSTEFPQSRIDEIKRDSLYKDMLTDEKINT
                     ILSGKINESVQPLPNITADDVAYAIYTSGSTGKPKGVVIKHGAAVNTINDIICKYNIKN
                     DDVFIGLANLAFDLSVFDVFGAFSVGAKLVLCENPRNVEEVWDLVTSSNVTIWNSVPML
                     MEMFVTFAETKLNSEDLDFSLLPKLRLVLLSGDWIPIDLPNKITQNFMDCEVVSLGGAT
                     EASIWSIYYNVKLIDSKWKSIPYGKPLSNQTYYVLDDFYQPCPIGVTGDLYIGGKGLAS
                     GYLNNPQKTESVFINHKEFGRIYKTGDLGYLNRSGFIVFKGRNDSQVKIN"
     CDS_motif       complement(2110..2199)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg48_4_0007"
                     /evalue="1.20E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg48_4"
                     /protein_end="886"
                     /protein_start="856"
                     /score="43.2"
                     /tool="antismash"
                     /translation="PIGVTGDLYIGGKGLASGYLNNPQKTESVF"
     CDS_motif       complement(2734..2793)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg48_4_0006"
                     /evalue="4.70E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg48_4"
                     /protein_end="678"
                     /protein_start="658"
                     /score="31.4"
                     /tool="antismash"
                     /translation="AYAIYTSGSTGKPKGVVIKH"
     CDS_motif       complement(2944..2982)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg48_4_0005"
                     /evalue="9.60E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg48_4"
                     /protein_end="608"
                     /protein_start="595"
                     /score="15.7"
                     /tool="antismash"
                     /translation="LGILKAGAAYIPL"
     CDS_motif       complement(3355..3426)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg48_4_0004"
                     /evalue="7.50E-06"
                     /label="Cy7"
                     /locus_tag="ctg48_4"
                     /protein_end="471"
                     /protein_start="447"
                     /score="18.9"
                     /tool="antismash"
                     /translation="TQTPQVTLDHQAMLTDDGVFLNWD"
     aSDomain        complement(3646..4506)
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg48_4_Heterocyclization.1"
                     /evalue="8.90E-66"
                     /label="ctg48_4_Heterocyclization.1"
                     /locus_tag="ctg48_4"
                     /protein_end="374"
                     /protein_start="87"
                     /score="214.1"
                     /tool="antismash"
                     /translation="KNNFKPTNVQMAYLTGRNSGFTLGGVSTHIYFEYDSDWDLSRFEE
                     IINCEIRRQPMLRATFLAGKVHINKVEDCKYTLNVLGSKPDDFNDVLKAQKDIQKYRNF
                     NPSKWPLFNFTAIKNSCGKSKILFDIDALISDGFSIRILFEDLVALYRGKEVNSISNKQ
                     LLNLLDTNSENVSDKSYWQNKILTLPQAPELPYSNKFSSVKKPTFSSVRKTLPLELWNK
                     IDKKCEAERVRPTFFLMACYAATLAKWSNQKDVLINCTLFDRNNDLPNANTIIGDFTSV
                     LLATYQ"
     CDS_motif       complement(3658..3702)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg48_4_0003"
                     /evalue="1.80E-04"
                     /label="Cy5"
                     /locus_tag="ctg48_4"
                     /protein_end="370"
                     /protein_start="355"
                     /score="14.1"
                     /tool="antismash"
                     /translation="PNANTIIGDFTSVLL"
     CDS_motif       complement(3757..3807)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg48_4_0002"
                     /evalue="3.40E-04"
                     /label="Cy4"
                     /locus_tag="ctg48_4"
                     /protein_end="337"
                     /protein_start="320"
                     /score="13.6"
                     /tool="antismash"
                     /translation="PTFFLMACYAATLAKWS"
     CDS_motif       complement(4054..4107)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg48_4_0001"
                     /evalue="3.10E-05"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg48_4"
                     /protein_end="238"
                     /protein_start="220"
                     /score="16.6"
                     /tool="antismash"
                     /translation="ISDGFSIRILFEDLVALY"
     aSDomain        complement(4567..4734)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg48_4_PP-binding.1"
                     /evalue="2.10E-11"
                     /label="ctg48_4_PP-binding.1"
                     /locus_tag="ctg48_4"
                     /protein_end="67"
                     /protein_start="11"
                     /score="36.1"
                     /tool="antismash"
                     /translation="IIQSYSEEKNIDNNTDLFELNISSIEISQILSQINREQSIKLTFA
                     DFMNCNTVNDL"
     CDS             complement(4769..5764)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_5"
                     /sec_met_domain="PF00881 (E-value: 8.7e-21, bitscore: 63.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKEDPIYFWDPSVSWAIDHGSINIKEVDFKGFPVILFKKFYDAA
                     KSGVAEKKFEDDSQLSVSDRRLIQLLFRRLIAENVLRKGLADVESVFKGQQRFINSDYE
                     PDYFLKPENTAKFHDKQLNRFTVNADNSENIMLNSDDNLFKELSKRKSVRHFEMYKKVS
                     FNDFSSLLGALSTKRDSESIKYYYPSAGGLYPNNFYIYVKPERIEKIPGGLYKLNPILR
                     QLELVNKNANITKNSEYFTNMNIFSESAFSIYITFDGKVNMPKYEGFGYAFGLIETGIG
                     LELLTNMATHLHLGTCIIGEMDFKKIERFFNLSENEIYMQSMELGLIGGE"
     CDS             complement(6226..6417)
                     /locus_tag="ctg48_6"
                     /transl_table=11
                     /translation="MNRYNEIEKLPYSYRIDTSLHPSETHTIEFIGKLYADLPDEMIAE
                     LEVIGNKTEQIFFENVFP"
     CDS             complement(6558..7256)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 109.8;
                     E-value: 1.9e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_7"
                     /transl_table=11
                     /translation="MLIRIVNTSKLTSSDIESLSVHIEKNMLKKISRKHMIQDQINSIA
                     GVGFTKKLLSQKFHISEGKIIFSTNAYGKPQANFPEMNFNWSHSGSFVAIIISEKSAVG
                     VDVEQIKVIKHNIDDFVKNQFPLIENQYYDGEPDSKKLEVFYRLWVSNEAFLKQMGIGL
                     LYGMEFFDLYIMKKYSCIIRTKSGIAMPIWWNELSSNNERLSVAACGFDMNERVTLLVC
                     DGHDLLRSIK"
     CDS             complement(7678..8904)
                     /gene_functions="other (smcogs) SMCOG1237:transposase
                     (Score: 255.3; E-value: 1.9e-77)"
                     /gene_kind="other"
                     /locus_tag="ctg48_8"
                     /transl_table=11
                     /translation="MSIVFGIDVSSRDSSVCVLQSGATREYKITNDTIGFKTLLIDLKE
                     YAEHPQIILEATGVYSRRITRFLDEYDYDYVLLNPLKAKKEINQGLRRNKTDRNDAYHL
                     ALAQDQNQHQPNRKEPDVYHQLQSLSRAYEELTHDIISSKNRLHKYLQLTFPELETIFN
                     NSRGVNYWYLVELFPHCQDVRNLEVSTIAKQIKDFKGYGINRAQKLAIKLKHLADLAYP
                     AVDQDDPERDEVVYYANRLLRLTADRERRSEEMIKLAKTLPNRDLEILMSIPGIAAITA
                     VRILAELGDIRRFSNPNKINAFVGIDPGRYQSGEKDSSLRISKHGNAVARKILYRAIGQ
                     IDLAAKTSPCHIADYYERKKQFSQTKGFKKIAIASIHKLLRTIYILIITDQMYDYNVAN
                     NNQKDFCRN"
ORIGIN
        1 gttcattcat ggggaatgcc tcctgtgatg ttttctgtgg ttactaaata tcataaggga
       61 aggcattccc tatttctata caattcagaa atcttttatg catttacaca agatatttta
      121 cgctctccat taagctgtcc aagctagaaa atccaattgt ttgtgacaca atcgaaatat
      181 tagcaattaa atttttatct gaatacacaa ctcccttcgg agtcccagtt gttcctgaag
      241 aaaaaagaat caatctttga acaatatctg ctacttcaac ttctacacta tctatttcag
      301 taggttgcaa atttaaaatg gcatcctcat caatctcgac tttatctagt attgagatat
      361 ctttgtcatc atttctagcc attttagcta agtacatata aaaccgatta ttaaatatca
      421 tttgagggcg acttaacgtc ttacttacca cttttaaaaa ttccaaatga tcatgcgaat
      481 aactaatagc acatggaact ggggttatcc cgcctagaaa gcaagcccaa ataagtagta
      541 atgtagcctg cggattaatt gtctgaatca caagcattga gcccgaattc acatcattgc
      601 gattaagtaa tctcaacaag ctaattgctc taccaataaa gtctttataa gatacaaaat
      661 tttcatgttc atcattaata aaatacatac catgttgagc atcttcacta acagatagga
      721 tggtttgaac tatactagac ggtttcatgc aattcctcca aattattcaa aatataacca
      781 gttactgtag ctactgaatc cttaatgaaa aaatgtccac cgggaaaatc ttttattgta
      841 attggcgcat cgaaatagcc ttgccaagcc tccttgttta aagctgtagc gtatacatca
      901 tctattccat ttaaaacaaa aacatgtttt tctgataaac taattttctt gctgtgatca
      961 taatgttcaa cagctcggta atcatcctta atcgtagacg tgaaaattga aagtaggtct
     1021 ggatacttta ataattcatc agaaatctca cccaatgttc caatctgatc tatgaattgt
     1081 tggtctgaaa gttgactaat atgaatttca tctacagctg acggtgctcc ttttccagac
     1141 atgaaacacg ctatgggttc cttcatttga agttgttcaa taatttttaa aaactctaat
     1201 tcaatgtaac ttcccatact atgccctaaa atagcatagt tatgattacc ggtacttttc
     1261 tgtattgtca taatttgttt aaaagtatca ctagctgctt cttcaattga aagataatca
     1321 ttttcattga atcgtgatcc atgacctttc atttcaagtg ggtatatgtt aatacttgta
     1381 tttttaaaat aaggaatcca tatattgtaa aaactagcca atccccctgc atgtggtatg
     1441 cagtataagt taatatcact tttcattttg agcttccttt ttctccagtt gatttaaaat
     1501 tactttcgat aaatcaaaaa tatttgaatt cttaaaaata tcaattaatt tgatggtatt
     1561 cgggtatttt ttctggacct cattaaataa ctcaacaatc agcaatgaat tcccgcctag
     1621 ttcaaaaaag ttatcagtga cattaacgtt cttcactttt aataagtcac taatagtatt
     1681 ttccagaaat tcctcaacgc tgtttttagg agcatcactt gaaacattct gatttataga
     1741 tgattctttg aaatctggca atgcacgtct attaaccttt ccatttttag tcaagggaac
     1801 ttctttcaat tgcatacaat acttaggcat catataccct ggtaaaaaat tacctgcata
     1861 ctttaaaata cttgcttctg tcacggatcc cacataatag accagaattt cctgatgctt
     1921 taccaccaca attacactaa taatatcagg cattttcaaa ataacatttt gaatttcctc
     1981 caattcaata cgaaagccat taatcttaac ctgagaatca tttctaccct taaaaacgat
     2041 gaagccagaa cgattcagat atcctaaatc accagtttta taaatccgac caaactcctt
     2101 gtggttaata aaaactgatt ctgttttttg gggattattt aaatagccac ttgccaatcc
     2161 ttttccaccg atatataaat caccagtcac tccaattgga catggttgat aaaaatcatc
     2221 taaaacataa taggtttgat tagataaagg tttcccgtac ggtatacttt tccatttaga
     2281 atcaattaat ttaacgttat agtaaattga ccagattgaa gcctcagttg caccaccaag
     2341 actcacaacc tcacaatcca taaagttttg tgtgatttta ttcggtagat caataggaat
     2401 ccagtcaccg ctcaacagta ctaatctcag ctttggaagt aaactgaaat ctaagtcttc
     2461 tgaatttaac ttagtttccg caaacgtcac aaacatttcc attagcattg gaacggaatt
     2521 ccatatcgta acattcgaac tagtaacaag atcccagact tcttcaacat tacgtggatt
     2581 ctcacataaa accaatttag cgccaactga aaatgcacca aatacatcaa acaccgataa
     2641 atcaaaagct aaatttgcta atccaataaa tacatcatca ttctttatgt tatatttaca
     2701 aataatgtcg ttaatcgtat ttacagctgc accatgcttt atcacaactc ctttaggctt
     2761 tccagtgctg cctgatgtat agattgcata agcaacatca tccgcagtta tatttggtaa
     2821 tggttgcaca gattcattta tttttccgct cagaatagta ttaatttttt cgtctgttaa
     2881 catatcttta tataatgaat ctcgtttgat ttcatcaatt cgtgattgtg gaaactcagt
     2941 agatagcgga atataagcgg cccctgcttt caagattccc aaaataccaa taatcgtgtc
     3001 tatagatctc atccctacta tcgctacaaa atcaccttta cttacttgaa ttttttgaag
     3061 taaataattt gcaatttggt tactcttaaa gtctaattca ccataagtaa tactagattc
     3121 ttgcccctca acggctatgc tttcagaata taacttcaca cttttgttaa atcgatccaa
     3181 catcgaattg cccaatacgc taatatcttt tgtgtcatta aaaatctgat atgcagctaa
     3241 agcgttttta cttgctaaac tactattttt attttcagca aaaccttcga ctaaaccgta
     3301 atagtcattg aacatcgctg atatagttgc ataatcaaat aattcatcaa cataatccca
     3361 atttaaaaac acaccatcat cggttagcat cgcctgatga tctagtgtaa cttgtggtgt
     3421 ctgtgttgca tagttttgaa cattacccag gctcaagttt ttatctgatt tattaaaaag
     3481 catactggta aaaacaactg gagccacaac atcagtcaat ggcttggcat cacgcttaat
     3541 tagcagctta gaaacttcta taccatcaaa atctttatgc tgataatcat ggataaaatc
     3601 agtttgaaat ctttttattg aattccatgt gaacattttt gagcgctgat acgtagctaa
     3661 taacacagac gtaaaatccc caataatggt atttgcattc ggtaaatcat tattccgatc
     3721 gaaaagtgta caattaatta atacatcctt ttgattactc catttagcca gtgttgcagc
     3781 gtaacaggcc attaaaaaga atgttggccg aacacgttct gcctcacatt ttttatctat
     3841 tttattccac aactccagcg gcaaagtttt tctaacgcta ctaaatgtcg gctttttaac
     3901 agaactaaac ttattactat aaggtaactc aggagcttgc ggtaatgtca aaattttgtt
     3961 ttgccaatat gacttatcac tgacgttttc agaatttgta tctaagagat ttagtaactg
     4021 cttattactt atgctattca cttctttccc tcgataaagc gcaaccaaat cttcaaacaa
     4081 aatccgaata ctaaatccat cagaaattaa tgcatctata tcaaaaagaa tttttgattt
     4141 tccgcacgaa tttttgattg ctgtaaaatt aaataatggc cacttgctag gattaaaatt
     4201 tcgatatttt tggatatcct tttgtgcctt taatacatcg ttaaaatcat ctggcttgga
     4261 gcctaataca tttaatgtat acttacaatc ttcgacctta ttaatatgaa ctttgccagc
     4321 taaaaaagtt gctcgtagca ttggttgtcg tctaatttcg caatttatga tttcctcgaa
     4381 tctagacaaa tcccagtcac tatcgtattc aaaatagatg tgtgttgaaa ctcctccaag
     4441 tgtaaaacca gaatttcttc cagttaaata tgccatttga acattagttg gtttgaaatt
     4501 atttttttta tattgtttct ctgctctttg ttccatttgt ggagcagtat ctagaattag
     4561 tttctgtaaa tcattgacag tattacagtt cataaaatca gcaaatgtta attttatgga
     4621 ctgttctcga tttatttgac ttaatatttg agaaatctca attgaagaaa tattaagctc
     4681 aaatagatct gtattgttat ctatattttt ctcttcagaa tatgattgaa tgatgctaat
     4741 tagattagtt tcctttttaa ttttcatttc attctcctcc aattaatcct agttccatgg
     4801 attgcatata tatttcattt tcagaaagat tgaaaaatct ttcgatcttc ttaaaatcca
     4861 tttcccctat tatgcaagtt cccaaatgca aatgcgtagc catatttgtt aacaattcca
     4921 acccaatacc cgtttcaata aggccaaatg catagccaaa cccttcatat tttggcatat
     4981 taactttgcc atcaaaagtg atataaatac taaaagccga ttcagaaaaa atattcatat
     5041 tagtaaagta ttcgctattc ttagtgatat tggcattttt attaactagt tccaattgcc
     5101 ttaaaatagg atttaatttg tacaaccctc cgggaatttt ctcaatcctt tctggtttta
     5161 cgtagatata aaaattatta ggatataaac caccagcact tggataatag tatttgatag
     5221 attcactatc gcgcttagtc gataatgcgc ctaaaaggga gctaaaatcg ttaaacgaga
     5281 cttttttata catctcaaaa tggcgaaccg attttctttt cgatagctct ttaaacagat
     5341 tgtcatcact attcaacatg atgttctctg aattatcagc attaaccgta aatctgttaa
     5401 gctgtttatc atgaaatttg gcagtgtttt ccggttttaa aaaataatca ggctcataat
     5461 cactattaat aaatcgctgt tgacctttaa atacagattc aacgtccgct aatcctttac
     5521 gcaaaacatt ttcggcaatt aatctcctga ataataattg tattaatcga cggtctgaaa
     5581 cactcaattg agaatcatct tcaaactttt tttctgcaac acctgactta gcagcgtcat
     5641 aaaatttctt aaataagata acgggaaacc ccttgaaatc tacttcttta atattgatac
     5701 ttccatgatc aatagcccag ctaacactgg gatcccaaaa ataaattgga tcttctttca
     5761 tcatttaatc tacttccttt ctgtgaatag acaaacaaca attaatctcg taactaacca
     5821 tttccagctt aaaaattcta gaacaatccc acccattggt gggcctgcgg ttgctaccac
     5881 cgcagtaact gcaccgataa ttcaagcttc ctgattagct tgcttgtgtc caaaaagact
     5941 caccgaattg gtctcaaact tcgatgcagg aataatagtt attgacatta ccggtacata
     6001 atcgtactta tccaatttgt gtctgtaaga tttgatttaa agtaagttgt tatgtcaggt
     6061 aaagcaaaat ttgtaaccat tgtgtctaac gtcaccatac ccattattaa tgacagtgct
     6121 accagcacca aataggcttc ttttgttttt aatcatcgaa acttcaactc ctttttattg
     6181 aaattaaaat ttctctaaga aacggtttct ttagaatact gtttattaag gaaacacatt
     6241 ttcaaaaaaa atttgttcag tcttgttccc tataacttct aattcagcaa tcatttcatc
     6301 tggtaaatct gcgtaaagtt taccaataaa ctcgattgta tgtgtttcag aaggatgcaa
     6361 cgaagtatct attctataag aatatggcaa cttttcaatc tcattatatc ggttcacaat
     6421 ccttaaaaaa tggaactaag ttctgacaat gtttcccttt tcaaaatacc ccctcaattc
     6481 gttaattgat ttcaaaacca ttataccgcc atctgtttcc tatttaaaca cattccctag
     6541 taaacacagg tgtaattcta cttaattgat ctcagcaagt catgcccatc acagactaat
     6601 aatgttactc tttcattcat atcaaaccca cacgcagcaa cggataatct ctcgttatta
     6661 ctagacaatt cattccacca tattggcata gcaatccctg atttcgttct tataatacag
     6721 gaatattttt tcattatata aagatcaaaa aattccattc catacaacaa accaatcccc
     6781 atctgcttta aaaaagcttc atttgatacc cataatcgat aaaacacctc taactttttg
     6841 ctatcgggtt ctccatcata atattgattc tcaattaaag gaaactgatt tttcacaaaa
     6901 tcatcaatat tatgcttgat aaccttaatt tgttctacat caacacctac tgctgatttt
     6961 tcagaaatga ttattgctac aaaagatcca gaatgagacc aattaaagtt catttctgga
     7021 aaatttgctt gcggttttcc ataggcatta gtggaaaaaa ttatttttcc ttcagaaata
     7081 tgaaactttt ggcttaaaag tttcttagtg aatccaacac cagcaattga attaatttga
     7141 tcttggatca tatgttttct tgaaatcttt tttaacatat ttttttctat atgtacacta
     7201 agactttcta tatcactact tgtaagctta ctagtattta ctatcctaat gagcataatc
     7261 agattctccc ctcacacatt tggccagctt tgaaaactct caccgattta accacgttcg
     7321 agtatttgga agttctgaca acctaattgt ttcaaaacat ccaggtcgga agtggcaact
     7381 ttaggttaac atacaaaatt gggttctaaa gatattttgt cgatctaagc taattcggtt
     7441 ggcattcgag catcgtagaa agttgcttta tatatataaa gattccagta taatggacta
     7501 agcaagaagt ttttctacgt aaagtcaagt atattaggac tctaaagtct taatttctga
     7561 catatttgac atcattgctt taatcggggc gttttattcc taaatttgga gcatcacaaa
     7621 gggcttcaaa gaaattactt ctttgaagtt aacttaggct ataatgaacc tgatcaatta
     7681 attacgacaa aagtcttttt gattattgtt ggctacgttg taatcataca tttgatcagt
     7741 gataatcaaa atatatatcg ttctaagcag tttatggatt gaagcaatgg caattttctt
     7801 gaaccccttc gtttgagaaa attgcttttt tcgttcatag taatctgcta tatgacatgg
     7861 actagtctta gccgctagat cgatttgtcc aattgcacga taaagaatct tccgcgcaac
     7921 ggcattgccg tgcttagaga tccttaaact agaatctttt tcccctgatt gatatctacc
     7981 tggatcaata ccaacaaaag catttatctt gtttggatta ctgaatcttc taatgtcgcc
     8041 taattcggct agaattcgga cagcagttat tgcagcgata ccaggaatgc tcattaagat
     8101 ttctagatcg cgattaggca aagtcttagc taatttaatc atttcctctg atctccgctc
     8161 gcgatcagct gtaagccgta ataatctatt ggcgtaataa accacttcat cacgctccgg
     8221 gtcgtcttga tcaactgctg gataagctaa atccgcgaga tgcttaagtt taatagctag
     8281 tttttgagca cggttaatac cataaccttt aaaatcttta atttgcttag cgatggttga
     8341 tacttcaaga tttctaacat cttggcagtg cggaaagagc tcaactaaat accagtaatt
     8401 aacacctcta gagttattga aaatggtttc taattctgga aaagttaact gtaaatattt
     8461 atgaagtcga ttcttggaag aaataatatc gtgagttaat tcctcataag cccgacttaa
     8521 agactgcaat tgatgataaa catcaggctc ttttcgatta ggttgatgct gattttgatc
     8581 ttgagctagt gccaaatggt aagcatcatt gcgatcggtt ttattgcgac gtaagccctg
     8641 attaatttct ttcttagcct ttaaaggatt aagaagaaca taatcataat cgtattcatc
     8701 taaaaatcta gtaattctgc gtgaataaac tccagttgct tctaagatga tttgtggatg
     8761 ttcggcgtat tcttttagat ctatcaacag agttttaaag ccgatagtat cgttagtgat
     8821 cttatattct cgtgtggcgc cactctgaag tacacaaaca ctggaatcac gactacttac
     8881 atctatgcca aagacaatgc tcatttttaa accctcctaa atagctgtta gtggttggaa
     8941 cgtatt
//
